NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|75677340|ref|NP_001028692|]
View 

WD repeat domain phosphoinositide-interacting protein 2 isoform e [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
77-301 6.90e-13

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.55  E-value: 6.90e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677340  77 SLYIHNIRDMKVLHTIREtppNPAGLCALSINNDNCYLAYpGSATiGEVQVFDTINLRAANMIPAHDSPLAALAFDASGT 156
Cdd:COG2319 143 TVRLWDLATGKLLRTLTG---HSGAVTSVAFSPDGKLLAS-GSDD-GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGK 217

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677340 157 KLATASEKGTViRVFSIPEGQKLFEFRRGVKrcvSICSLAFSMDGMFLSASSNTETVHIFKLETvkekpPEEPTTWTGYF 236
Cdd:COG2319 218 LLASGSADGTV-RLWDLATGKLLRTLTGHSG---SVRSVAFSPDGRLLASGSADGTVRLWDLAT-----GELLRTLTGHS 288

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677340 237 GKVLmaSTSYLPSqvtemfnqGRAFA------TVRL----------PFCGHKN-ICSLATIQKIPRLLVGAADGYLYMYN 299
Cdd:COG2319 289 GGVN--SVAFSPD--------GKLLAsgsddgTVRLwdlatgkllrTLTGHTGaVRSVAFSPDGKTLASGSDDGTVRLWD 358


                ..
gi 75677340 300 LD 301
Cdd:COG2319 359 LA 360
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
77-301 6.90e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.55  E-value: 6.90e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677340  77 SLYIHNIRDMKVLHTIREtppNPAGLCALSINNDNCYLAYpGSATiGEVQVFDTINLRAANMIPAHDSPLAALAFDASGT 156
Cdd:COG2319 143 TVRLWDLATGKLLRTLTG---HSGAVTSVAFSPDGKLLAS-GSDD-GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGK 217

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677340 157 KLATASEKGTViRVFSIPEGQKLFEFRRGVKrcvSICSLAFSMDGMFLSASSNTETVHIFKLETvkekpPEEPTTWTGYF 236
Cdd:COG2319 218 LLASGSADGTV-RLWDLATGKLLRTLTGHSG---SVRSVAFSPDGRLLASGSADGTVRLWDLAT-----GELLRTLTGHS 288

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677340 237 GKVLmaSTSYLPSqvtemfnqGRAFA------TVRL----------PFCGHKN-ICSLATIQKIPRLLVGAADGYLYMYN 299
Cdd:COG2319 289 GGVN--SVAFSPD--------GKLLAsgsddgTVRLwdlatgkllrTLTGHTGaVRSVAFSPDGKTLASGSDDGTVRLWD 358


                ..
gi 75677340 300 LD 301
Cdd:COG2319 359 LA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 125-304 2.58e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.65  E-value: 2.58e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677340 125 VQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTvIRVFSIPEGQKLFEFrRGVKRcvSICSLAFSMDGMFL 204
Cdd:cd00200  75 IRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKT-IKVWDVETGKCLTTL-RGHTD--WVNSVAFSPDGTFV 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677340 205 SASSNTETVHIFKLETVKEKppeepTTWTGYFGKVLmaSTSYLPSqvtemfnqGRAFA------TVRL----------PF 268
Cdd:cd00200 151 ASSSQDGTIKLWDLRTGKCV-----ATLTGHTGEVN--SVAFSPD--------GEKLLssssdgTIKLwdlstgkclgTL 215

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 75677340 269 CGHKN-ICSLATIQKiPRLLVGAA-DGYLYMYNLDPQE 304
Cdd:cd00200 216 RGHENgVNSVAFSPD-GYLLASGSeDGTIRVWDLRTGE 252
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
77-301 6.90e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.55  E-value: 6.90e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677340  77 SLYIHNIRDMKVLHTIREtppNPAGLCALSINNDNCYLAYpGSATiGEVQVFDTINLRAANMIPAHDSPLAALAFDASGT 156
Cdd:COG2319 143 TVRLWDLATGKLLRTLTG---HSGAVTSVAFSPDGKLLAS-GSDD-GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGK 217

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677340 157 KLATASEKGTViRVFSIPEGQKLFEFRRGVKrcvSICSLAFSMDGMFLSASSNTETVHIFKLETvkekpPEEPTTWTGYF 236
Cdd:COG2319 218 LLASGSADGTV-RLWDLATGKLLRTLTGHSG---SVRSVAFSPDGRLLASGSADGTVRLWDLAT-----GELLRTLTGHS 288

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677340 237 GKVLmaSTSYLPSqvtemfnqGRAFA------TVRL----------PFCGHKN-ICSLATIQKIPRLLVGAADGYLYMYN 299
Cdd:COG2319 289 GGVN--SVAFSPD--------GKLLAsgsddgTVRLwdlatgkllrTLTGHTGaVRSVAFSPDGKTLASGSDDGTVRLWD 358


                ..
gi 75677340 300 LD 301
Cdd:COG2319 359 LA 360
WD40 COG2319
WD40 repeat [General function prediction only];
80-239 1.25e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.70  E-value: 1.25e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677340  80 IHNIRDMKVLHTIRetpPNPAGLCALSINNDNCYLAYpGSATiGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLA 159
Cdd:COG2319 230 LWDLATGKLLRTLT---GHSGSVRSVAFSPDGRLLAS-GSAD-GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLA 304

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677340 160 TASEKGTViRVFSIPEGQKLFEFRRGVKRcvsICSLAFSMDGMFLSASSNTETVHIFKLETvkekpPEEPTTWTGYFGKV 239
Cdd:COG2319 305 SGSDDGTV-RLWDLATGKLLRTLTGHTGA---VRSVAFSPDGKTLASGSDDGTVRLWDLAT-----GELLRTLTGHTGAV 375
WD40 COG2319
WD40 repeat [General function prediction only];
77-220 5.39e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 60.70  E-value: 5.39e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677340  77 SLYIHNIRDMKVLHTIRetpPNPAGLCALSINNDNCYLAYpGSATiGEVQVFDTINLRAANMIPAHDSPLAALAFDASGT 156
Cdd:COG2319 269 TVRLWDLATGELLRTLT---GHSGGVNSVAFSPDGKLLAS-GSDD-GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGK 343

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 75677340 157 KLATASEKGTViRVFSIPEGQKLFEFRRGVKRcvsICSLAFSMDGMFLSASSNTETVHIFKLET 220
Cdd:COG2319 344 TLASGSDDGTV-RLWDLATGELLRTLTGHTGA---VTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
123-239 1.36e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.15  E-value: 1.36e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677340 123 GEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTViRVFSIPEGQKLFEFrRGVKRCVSicSLAFSMDGM 202
Cdd:COG2319 100 GTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV-RLWDLATGKLLRTL-TGHSGAVT--SVAFSPDGK 175

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 75677340 203 FLSASSNTETVHIFKLETvkekpPEEPTTWTGYFGKV 239
Cdd:COG2319 176 LLASGSDDGTVRLWDLAT-----GKLLRTLTGHTGAV 207
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 125-304 2.58e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.65  E-value: 2.58e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677340 125 VQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTvIRVFSIPEGQKLFEFrRGVKRcvSICSLAFSMDGMFL 204
Cdd:cd00200  75 IRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKT-IKVWDVETGKCLTTL-RGHTD--WVNSVAFSPDGTFV 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677340 205 SASSNTETVHIFKLETVKEKppeepTTWTGYFGKVLmaSTSYLPSqvtemfnqGRAFA------TVRL----------PF 268
Cdd:cd00200 151 ASSSQDGTIKLWDLRTGKCV-----ATLTGHTGEVN--SVAFSPD--------GEKLLssssdgTIKLwdlstgkclgTL 215

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 75677340 269 CGHKN-ICSLATIQKiPRLLVGAA-DGYLYMYNLDPQE 304
Cdd:cd00200 216 RGHENgVNSVAFSPD-GYLLASGSeDGTIRVWDLRTGE 252
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-224 9.57e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.11  E-value: 9.57e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677340  80 IHNIRDMKVLHTIREtppNPAGLCALSINNDNCYLAypGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLA 159
Cdd:cd00200 119 VWDVETGKCLTTLRG---HTDWVNSVAFSPDGTFVA--SSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLL 193

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 75677340 160 TASEKGTvIRVFSIPEGQKLFEFRRgvkRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEK 224
Cdd:cd00200 194 SSSSDGT-IKLWDLSTGKCLGTLRG---HENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECV 254
WD40 COG2319
WD40 repeat [General function prediction only];
119-239 1.71e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.52  E-value: 1.71e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677340 119 SATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTViRVFSIPEGQKLFEFRRGVKrcvSICSLAFS 198
Cdd:COG2319  54 GAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTV-RLWDLATGLLLRTLTGHTG---AVRSVAFS 129

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 75677340 199 MDGMFLSASSNTETVHIFKLETvkekpPEEPTTWTGYFGKV 239
Cdd:COG2319 130 PDGKTLASGSADGTVRLWDLAT-----GKLLRTLTGHSGAV 165
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 139-314 7.39e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.33  E-value: 7.39e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677340 139 IPAHDSPLAALAFDASGTKLATASEKGTvIRVFSIPEGQKLFEFR---RGVKRCVSICslafsmDGMFLSASSNTETVHI 215
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKLLATGSGDGT-IKVWDLETGELLRTLKghtGPVRDVAASA------DGTYLASGSSDKTIRL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677340 216 FKLETvkekpPEEPTTWTGYFGKVL---------MASTSYLPSQV----TEMFNQGRAFAtvrlpfcGHKN-ICSLATIQ 281
Cdd:cd00200  78 WDLET-----GECVRTLTGHTSYVSsvafspdgrILSSSSRDKTIkvwdVETGKCLTTLR-------GHTDwVNSVAFSP 145

                       170       180       190
                ....*....|....*....|....*....|...
gi 75677340 282 KIPRLLVGAADGYLYMYNLDpqEGGECALMKQH 314
Cdd:cd00200 146 DGTFVASSSQDGTIKLWDLR--TGKCVATLTGH 176
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
61-176 4.78e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 44.30  E-value: 4.78e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677340  61 LAVKLNRQRLIVCLEES--LYIHNIRDMKVLHTIrETPPNPAGLcALSINNDNCYLAYPGSATIGE-VQVFDTINLRAAN 137
Cdd:COG3391 115 LAVDPDGGRLYVADSGNgrVSVIDTATGKVVATI-PVGAGPHGI-AVDPDGKRLYVANSGSNTVSViVSVIDTATGKVVA 192

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 75677340 138 MIPAHDSPLaALAFDASGTKL-------ATASEKGTVIRVFSIPEG 176
Cdd:COG3391 193 TIPVGGGPV-GVAVSPDGRRLyvanrgsNTSNGGSNTVSVIDLATL 237
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 57-172 1.25e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.48  E-value: 1.25e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677340  57 SNTILAVKL--NRQRLIVC-LEESLYIHNIRDMKVLHTIREtppNPAGLCALSINNDNCYLAypGSATIGEVQVFDTINL 133
Cdd:cd00200 177 TGEVNSVAFspDGEKLLSSsSDGTIKLWDLSTGKCLGTLRG---HENGVNSVAFSPDGYLLA--SGSEDGTIRVWDLRTG 251

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 75677340 134 RAANMIPAHDSPLAALAFDASGTKLATASEKGTvIRVFS 172
Cdd:cd00200 252 ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGT-IRIWD 289
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
123-216 4.58e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.22  E-value: 4.58e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677340 123 GEVQVFDTINLRAANMIPAHDSPlAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGvkrcVSICSLAFSMDGM 202
Cdd:COG3391  90 GRVSVIDLATGKVVATIPVGGGP-RGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVG----AGPHGIAVDPDGK 164

                        90
                ....*....|....*
gi 75677340 203 FL-SASSNTETVHIF 216
Cdd:COG3391 165 RLyVANSGSNTVSVI 179
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-223 9.85e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.78  E-value: 9.85e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677340  54 YSYSNTILAVKLNRQrlivcleesLYIHNIRDMKVLHTIREtppNPAGLCALSINNDNCYLAypGSATIGEVQVFDTINL 133
Cdd:cd00200  60 SADGTYLASGSSDKT---------IRLWDLETGECVRTLTG---HTSYVSSVAFSPDGRILS--SSSRDKTIKVWDVETG 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677340 134 RAANMIPAHDSPLAALAFDASGTKLATASEKGTvIRVFSIPEGQ--KLFEFRRGvkrcvSICSLAFSMDGMFLSASSNTE 211
Cdd:cd00200 126 KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT-IKLWDLRTGKcvATLTGHTG-----EVNSVAFSPDGEKLLSSSSDG 199

                       170
                ....*....|..
gi 75677340 212 TVHIFKLETVKE 223
Cdd:cd00200 200 TIKLWDLSTGKC 211
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH