|
Name |
Accession |
Description |
Interval |
E-value |
| Atypical_Card |
pfam18461 |
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts ... |
1-94 |
5.85e-48 |
|
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts a six alpha-helix bundle with a general death fold. Structure and sequence analysis of the NLRC5-N indicate that it possesses a fold similar to the one of the death-fold domains; however, it displays significant differences in the number of core alpha-helices and their relative orientation. Hence, it is suggested that NLRC5 belongs to the caspase recruitment domain (CARD) subfamily as an atypical CARD.
:
Pssm-ID: 436519 Cd Length: 95 Bit Score: 166.36 E-value: 5.85e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1 MDAESIRLNNENLWAWLVRLLSKNPEWLSAKLRSFLPTMDLDCSYEPSNP-EVIHRQLNRLFAQGMATWKSFINDLCFEL 79
Cdd:pfam18461 1 MDPESLQLGTENLWPWLVRLLSKNPEWLSAKVKFFLPNMDLGSSNEAPDPtQKVILQLDRLEAQGLATWQSFIHCVCMEL 80
|
90
....*....|....*
gi 254692966 80 DVPLDMEIPLVSIWG 94
Cdd:pfam18461 81 EVPLDLEVPLLSTWG 95
|
|
| RNA1 super family |
cl34950 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1596-1905 |
2.56e-34 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
The actual alignment was detected with superfamily member COG5238:
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 138.38 E-value: 2.56e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1596 LAAILPKLPELRKFDLSHNQIGDVGTQCL-AAILPKLPELRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRNQIGD 1674
Cdd:COG5238 143 LIQVLKDPLGGNAVHLLGLAARLGLLAAIsMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGD 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1675 VGTQCLAAILPKLPELRKFDLSGNRIGPAGGVQLVKSLTHFEHLEEIKLGNNALGEPTALELAQRL--PPQLRVLCLPSS 1752
Cdd:COG5238 223 EGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALqgNTTLTSLDLSVN 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1753 HLGPEGALGLAQALEQCPHIEEVSLAENNlaggvprfskrlpllrqidlefckIEDQAARHLAANLTLFPALEKLLLSGN 1832
Cdd:COG5238 303 RIGDEGAIALAEGLQGNKTLHTLNLAYNG------------------------IGAQGAIALAKALQENTTLHSLDLSDN 358
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254692966 1833 LLGDEVAAELAQVLPQMGQLKKVNLEWNRITARGAQLLAQGLvQGSCVPVIRLWNNPILNDVAQSLQSQEPRL 1905
Cdd:COG5238 359 QIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDAL-QTNRLHTLILDGNLIGAEAQQRLEQLLERI 430
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
223-385 |
1.02e-30 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
:
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 119.72 E-value: 1.02e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 223 RVTVLLGKAGMGKTTLAYRLRWRWAQGQLDR-FQALFLFEFRQLNMITQLPTLPQLLFDLYLMPESEPDAVFQYLKENAQ 301
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQgFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 302 EVLLIFDGLDEALHADSVgTDNAGSALTLFSELCHGNLLPGCWVMTTSRPG---KLPSCVPtEAATVHMWGFDGLRVEKY 378
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQ-LDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalrDLRRGLE-EPRYLEVRGFSESDRKQY 158
|
....*..
gi 254692966 379 VTCFFSD 385
Cdd:pfam05729 159 VRKYFSD 165
|
|
| RNA1 super family |
cl34950 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1445-1716 |
2.95e-26 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
The actual alignment was detected with superfamily member COG5238:
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 114.12 E-value: 2.95e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1445 LETEHSHLMIQLVETYARLQQLSLSQVSFNDN--DGTSSKLLQNILLSSCELKSFRLTFSQVSTKSLTHLAFGLGHCHHL 1522
Cdd:COG5238 159 LGLAARLGLLAAISMAKALQNNSVETVYLGCNqiGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSL 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1523 EELDFSNNSLREEDTELLMGALQGTCRLKKLHLSFLPLGASSLALLIQGLSRMTLLQDLCLSHNQIGDVGTQCLAAILPK 1602
Cdd:COG5238 239 TTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQG 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1603 LPELRKFDLSHNQIGDVGTQCLAAILPKLPELRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRNQIGDVGTQCLAA 1682
Cdd:COG5238 319 NKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALID 398
|
250 260 270
....*....|....*....|....*....|....
gi 254692966 1683 ILpKLPELRKFDLSGNRIGPAGGVQLVKSLTHFE 1716
Cdd:COG5238 399 AL-QTNRLHTLILDGNLIGAEAQQRLEQLLERIK 431
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
223-673 |
4.49e-22 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
:
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 104.12 E-value: 4.49e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 223 RVTVLLGKAGMGKTTLAYRLRWRWAQGQLDRFQAL-FLFEFRQLNmitQLPTLPQLLFDLYLMPESEPDAVFQYLKENAQ 301
Cdd:COG5635 181 KRLLILGEPGSGKTTLLRYLALELAERYLDAEDPIpILIELRDLA---EEASLEDLLAEALEKRGGEPEDALERLLRNGR 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 302 eVLLIFDGLDEAlhADSVGTDNAGSALTLFSELChgnllPGCWVMTTSRPGKLPSCVPTEAATVHMWGFDGLRVEKYVTC 381
Cdd:COG5635 258 -LLLLLDGLDEV--PDEADRDEVLNQLRRFLERY-----PKARVIITSRPEGYDSSELEGFEVLELAPLSDEQIEEFLKK 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 382 FFSDLLSQ-ELALKEMRTNARLRGMCAIPALCTVTCFCLRrllpgsspgQSAALLPTITQLYLQMVETF---------SP 451
Cdd:COG5635 330 WFEATERKaERLLEALEENPELRELARNPLLLTLLALLLR---------ERGELPDTRAELYEQFVELLlerwdeqrgLT 400
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 452 SETLLDTSILG--FGKVALRGLDTGKVVFSVED----ISPQLMSFGAVHSLLTSFCIHT----RPGHEEigYAFVHLSLQ 521
Cdd:COG5635 401 IYRELSREELRelLSELALAMQENGRTEFAREEleeiLREYLGRRKDAEALLDELLLRTgllvERGEGR--YSFAHRSFQ 478
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 522 EFFAALYLMASHTVD-KDTLVEYVTlNSHW--VLRtkgrlglsdhlpaFLAGLASHTCHM--FLCQLAQQDRAWVGSRQA 596
Cdd:COG5635 479 EYLAARALVEELDEElLELLAEHLE-DPRWreVLL-------------LLAGLLDDVKQIkeLIDALLARDDAAALALAA 544
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 254692966 597 AVIQVLRKLASRKLTGPKMIELYHCVAETQDLELARFTAQSLPSRLSFHNFPLTHADLAALANILEHRDDPIHLDFD 673
Cdd:COG5635 545 ALLLALLLALALLALLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLLLLLLLLLLLLLLALALL 621
|
|
| RNA1 super family |
cl34950 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
640-936 |
6.58e-15 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
The actual alignment was detected with superfamily member COG5238:
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 79.45 E-value: 6.58e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 640 SRLSFHNFPLTHADLAALANILEHRDDPI--HLDFDGCP-----LEPHCPEALVGCGQVENLSFKSRKCGDAFAEALCRS 712
Cdd:COG5238 124 AKTLEDSLILYLALPRRINLIQVLKDPLGgnAVHLLGLAarlglLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEA 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 713 LPTMGSLKTLGLTGSRITAQGISHLIQTLPLCSQLEEVSLHDNQLKDPEVLSLVELLPSLPKLQKLDLSRNSfsrsills 792
Cdd:COG5238 204 LTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQ-------- 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 793 lvkvaITCPTVRKLqvreldlifylspvtetatqqsgASDVQGKDSLKegqsrSLQLRLQkcQLRIRDAEALVELFQKSP 872
Cdd:COG5238 276 -----IGAEGAIAL-----------------------AKALQGNTTLT-----SLDLSVN--RIGDEGAIALAEGLQGNK 320
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254692966 873 QLEEVNLSGNHLEDDGCRLVAEAASQLHIAQKLDLSDNGLSQTGVTYVLKAMSTCGTLEDLHIS 936
Cdd:COG5238 321 TLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLG 384
|
|
| RNA1 super family |
cl34950 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
861-1059 |
3.42e-13 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
The actual alignment was detected with superfamily member COG5238:
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 74.06 E-value: 3.42e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 861 AEALVELFQKSPQLEEVNLSGNHLEDDGCRLVAEAASQLHIAQKLDLSDNGLSQTGVTYVLKAMSTCGTLEDLHISLlNN 940
Cdd:COG5238 225 AEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSV-NR 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 941 tvvLTFAqepreqegSCKGRAPLISFVSPVTSelsqrsrrIRLTHCGFLAKHTETLCEALRASCQTHNLDhldLSDNSLG 1020
Cdd:COG5238 304 ---IGDE--------GAIALAEGLQGNKTLHT--------LNLAYNGIGAQGAIALAKALQENTTLHSLD---LSDNQIG 361
|
170 180 190
....*....|....*....|....*....|....*....
gi 254692966 1021 GKGVILLTELLPGLGPLKSLNLSRNGLSMDAVFSLVQCL 1059
Cdd:COG5238 362 DEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDAL 400
|
|
| PPP1R42 super family |
cl42388 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1007-1307 |
2.85e-06 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
The actual alignment was detected with superfamily member cd00116:
Pssm-ID: 455733 [Multi-domain] Cd Length: 319 Bit Score: 51.59 E-value: 2.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1007 HNLDHLDLSDNSLGGKGVILLTELLPGLGPLKSLNLSRNGLSMD--AVFSLVQCLSSLQWVFHLDVSlesDCIFLrgagt 1084
Cdd:cd00116 23 LCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIprGLQSLLQGLTKGCGLQELDLS---DNALG----- 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1085 srdalepkfQTGVQVLE-LSQRYTSRSFCLQECQLEPTSLTFLCAtlekspGPLEVQLSCKSLsddslkILLQCLpqlpq 1163
Cdd:cd00116 95 ---------PDGCGVLEsLLRSSSLQELKLNNNGLGDRGLRLLAK------GLKDLPPALEKL------VLGRNR----- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1164 lsllqlrhtvLSSRSPFLLADIFNLCPRVRKVTL----------RSLCHAVLHFdsneeQEGVCCGFPGCSLSQEHMETL 1233
Cdd:cd00116 149 ----------LEGASCEALAKALRANRDLKELNLanngigdagiRALAEGLKAN-----CNLEVLDLNNNGLTDEGASAL 213
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 254692966 1234 CCALSKCNALSQLDLTDNLLGDIGLRCLLECLPQLPIS-GWLDLSHNNISQEGILYLLETLPSYPNIQEVSVSLS 1307
Cdd:cd00116 214 AETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISlLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGN 288
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Atypical_Card |
pfam18461 |
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts ... |
1-94 |
5.85e-48 |
|
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts a six alpha-helix bundle with a general death fold. Structure and sequence analysis of the NLRC5-N indicate that it possesses a fold similar to the one of the death-fold domains; however, it displays significant differences in the number of core alpha-helices and their relative orientation. Hence, it is suggested that NLRC5 belongs to the caspase recruitment domain (CARD) subfamily as an atypical CARD.
Pssm-ID: 436519 Cd Length: 95 Bit Score: 166.36 E-value: 5.85e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1 MDAESIRLNNENLWAWLVRLLSKNPEWLSAKLRSFLPTMDLDCSYEPSNP-EVIHRQLNRLFAQGMATWKSFINDLCFEL 79
Cdd:pfam18461 1 MDPESLQLGTENLWPWLVRLLSKNPEWLSAKVKFFLPNMDLGSSNEAPDPtQKVILQLDRLEAQGLATWQSFIHCVCMEL 80
|
90
....*....|....*
gi 254692966 80 DVPLDMEIPLVSIWG 94
Cdd:pfam18461 81 EVPLDLEVPLLSTWG 95
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1596-1905 |
2.56e-34 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 138.38 E-value: 2.56e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1596 LAAILPKLPELRKFDLSHNQIGDVGTQCL-AAILPKLPELRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRNQIGD 1674
Cdd:COG5238 143 LIQVLKDPLGGNAVHLLGLAARLGLLAAIsMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGD 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1675 VGTQCLAAILPKLPELRKFDLSGNRIGPAGGVQLVKSLTHFEHLEEIKLGNNALGEPTALELAQRL--PPQLRVLCLPSS 1752
Cdd:COG5238 223 EGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALqgNTTLTSLDLSVN 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1753 HLGPEGALGLAQALEQCPHIEEVSLAENNlaggvprfskrlpllrqidlefckIEDQAARHLAANLTLFPALEKLLLSGN 1832
Cdd:COG5238 303 RIGDEGAIALAEGLQGNKTLHTLNLAYNG------------------------IGAQGAIALAKALQENTTLHSLDLSDN 358
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254692966 1833 LLGDEVAAELAQVLPQMGQLKKVNLEWNRITARGAQLLAQGLvQGSCVPVIRLWNNPILNDVAQSLQSQEPRL 1905
Cdd:COG5238 359 QIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDAL-QTNRLHTLILDGNLIGAEAQQRLEQLLERI 430
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1520-1782 |
4.67e-31 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 125.55 E-value: 4.67e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1520 HHLEELDFSNNSLREEDTELLMGALQGTCRLKKLHLSFLPLGAS--SLALLIQGLSRMTLLQDLCLSHNQIGDVGTQCLA 1597
Cdd:cd00116 23 LCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIprGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLE 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1598 AILpKLPELRKFDLSHNQIGDVGTQCLAAILPKLPE-LRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRNQIGDVG 1676
Cdd:cd00116 103 SLL-RSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1677 TQCLAAILPKLPELRKFDLSGNRIGPAGGVQLVKSLTHFEHLEEIKLGNNALGEPTALELAQRLP---PQLRVLCLPSSH 1753
Cdd:cd00116 182 IRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLspnISLLTLSLSCND 261
|
250 260
....*....|....*....|....*....
gi 254692966 1754 LGPEGALGLAQALEQCPHIEEVSLAENNL 1782
Cdd:cd00116 262 ITDDGAKDLAEVLAEKESLLELDLRGNKF 290
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
223-385 |
1.02e-30 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 119.72 E-value: 1.02e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 223 RVTVLLGKAGMGKTTLAYRLRWRWAQGQLDR-FQALFLFEFRQLNMITQLPTLPQLLFDLYLMPESEPDAVFQYLKENAQ 301
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQgFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 302 EVLLIFDGLDEALHADSVgTDNAGSALTLFSELCHGNLLPGCWVMTTSRPG---KLPSCVPtEAATVHMWGFDGLRVEKY 378
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQ-LDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalrDLRRGLE-EPRYLEVRGFSESDRKQY 158
|
....*..
gi 254692966 379 VTCFFSD 385
Cdd:pfam05729 159 VRKYFSD 165
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1445-1716 |
2.95e-26 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 114.12 E-value: 2.95e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1445 LETEHSHLMIQLVETYARLQQLSLSQVSFNDN--DGTSSKLLQNILLSSCELKSFRLTFSQVSTKSLTHLAFGLGHCHHL 1522
Cdd:COG5238 159 LGLAARLGLLAAISMAKALQNNSVETVYLGCNqiGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSL 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1523 EELDFSNNSLREEDTELLMGALQGTCRLKKLHLSFLPLGASSLALLIQGLSRMTLLQDLCLSHNQIGDVGTQCLAAILPK 1602
Cdd:COG5238 239 TTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQG 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1603 LPELRKFDLSHNQIGDVGTQCLAAILPKLPELRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRNQIGDVGTQCLAA 1682
Cdd:COG5238 319 NKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALID 398
|
250 260 270
....*....|....*....|....*....|....
gi 254692966 1683 ILpKLPELRKFDLSGNRIGPAGGVQLVKSLTHFE 1716
Cdd:COG5238 399 AL-QTNRLHTLILDGNLIGAEAQQRLEQLLERIK 431
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1437-1684 |
1.86e-25 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 109.37 E-value: 1.86e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1437 ALRLAHCDLETEHS----HLMIQLVETYARLQQLSLSQVSFNDndgTSSKLLQNILLSScELKSFRLTFSQVSTKSLTHL 1512
Cdd:cd00116 53 LKELCLSLNETGRIprglQSLLQGLTKGCGLQELDLSDNALGP---DGCGVLESLLRSS-SLQELKLNNNGLGDRGLRLL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1513 AFGLGHC-HHLEELDFSNNSLREEDTELLMGALQGTCRLKKLHLSFLPLGASSLALLIQGLSRMTLLQDLCLSHNQIGDV 1591
Cdd:cd00116 129 AKGLKDLpPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDE 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1592 GTQCLAAILPKLPELRKFDLSHNQIGDVGTQCLAAILPKL-PELRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRN 1670
Cdd:cd00116 209 GASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPnISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGN 288
|
250
....*....|....
gi 254692966 1671 QIGDVGTQCLAAIL 1684
Cdd:cd00116 289 KFGEEGAQLLAESL 302
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
223-673 |
4.49e-22 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 104.12 E-value: 4.49e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 223 RVTVLLGKAGMGKTTLAYRLRWRWAQGQLDRFQAL-FLFEFRQLNmitQLPTLPQLLFDLYLMPESEPDAVFQYLKENAQ 301
Cdd:COG5635 181 KRLLILGEPGSGKTTLLRYLALELAERYLDAEDPIpILIELRDLA---EEASLEDLLAEALEKRGGEPEDALERLLRNGR 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 302 eVLLIFDGLDEAlhADSVGTDNAGSALTLFSELChgnllPGCWVMTTSRPGKLPSCVPTEAATVHMWGFDGLRVEKYVTC 381
Cdd:COG5635 258 -LLLLLDGLDEV--PDEADRDEVLNQLRRFLERY-----PKARVIITSRPEGYDSSELEGFEVLELAPLSDEQIEEFLKK 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 382 FFSDLLSQ-ELALKEMRTNARLRGMCAIPALCTVTCFCLRrllpgsspgQSAALLPTITQLYLQMVETF---------SP 451
Cdd:COG5635 330 WFEATERKaERLLEALEENPELRELARNPLLLTLLALLLR---------ERGELPDTRAELYEQFVELLlerwdeqrgLT 400
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 452 SETLLDTSILG--FGKVALRGLDTGKVVFSVED----ISPQLMSFGAVHSLLTSFCIHT----RPGHEEigYAFVHLSLQ 521
Cdd:COG5635 401 IYRELSREELRelLSELALAMQENGRTEFAREEleeiLREYLGRRKDAEALLDELLLRTgllvERGEGR--YSFAHRSFQ 478
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 522 EFFAALYLMASHTVD-KDTLVEYVTlNSHW--VLRtkgrlglsdhlpaFLAGLASHTCHM--FLCQLAQQDRAWVGSRQA 596
Cdd:COG5635 479 EYLAARALVEELDEElLELLAEHLE-DPRWreVLL-------------LLAGLLDDVKQIkeLIDALLARDDAAALALAA 544
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 254692966 597 AVIQVLRKLASRKLTGPKMIELYHCVAETQDLELARFTAQSLPSRLSFHNFPLTHADLAALANILEHRDDPIHLDFD 673
Cdd:COG5635 545 ALLLALLLALALLALLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLLLLLLLLLLLLLLALALL 621
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
640-936 |
6.58e-15 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 79.45 E-value: 6.58e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 640 SRLSFHNFPLTHADLAALANILEHRDDPI--HLDFDGCP-----LEPHCPEALVGCGQVENLSFKSRKCGDAFAEALCRS 712
Cdd:COG5238 124 AKTLEDSLILYLALPRRINLIQVLKDPLGgnAVHLLGLAarlglLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEA 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 713 LPTMGSLKTLGLTGSRITAQGISHLIQTLPLCSQLEEVSLHDNQLKDPEVLSLVELLPSLPKLQKLDLSRNSfsrsills 792
Cdd:COG5238 204 LTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQ-------- 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 793 lvkvaITCPTVRKLqvreldlifylspvtetatqqsgASDVQGKDSLKegqsrSLQLRLQkcQLRIRDAEALVELFQKSP 872
Cdd:COG5238 276 -----IGAEGAIAL-----------------------AKALQGNTTLT-----SLDLSVN--RIGDEGAIALAEGLQGNK 320
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254692966 873 QLEEVNLSGNHLEDDGCRLVAEAASQLHIAQKLDLSDNGLSQTGVTYVLKAMSTCGTLEDLHIS 936
Cdd:COG5238 321 TLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLG 384
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
735-1045 |
1.61e-13 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 73.54 E-value: 1.61e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 735 SHLIQTLPLCSQLEEVSLHDNQLKDPEVLSLVELLPSLPKLQKLDLSRNSFSRS--ILLSLVKVAITCPTVRKLQVRELD 812
Cdd:cd00116 13 ERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIprGLQSLLQGLTKGCGLQELDLSDNA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 813 LIFYLSPVTETATQ----------QSGASDVQGK---DSLKEGQSRSLQLRLQKCQLRIRDAEALVELFQKSPQLEEVNL 879
Cdd:cd00116 93 LGPDGCGVLESLLRssslqelklnNNGLGDRGLRllaKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 880 SGNHLEDDGCRLVAEAASQLHIAQKLDLSDNGLSQTGVTYVLKAMSTCGTLEDLHIsllnntvvltfaqepreqeGSCKG 959
Cdd:cd00116 173 ANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNL-------------------GDNNL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 960 RAPLISFVSPVTSELSQRSRRIRLTHCGFLAKHTETLCEALRASCQthnLDHLDLSDNSLGGKGVILLTELLPGLGP-LK 1038
Cdd:cd00116 234 TDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKES---LLELDLRGNKFGEEGAQLLAESLLEPGNeLE 310
|
....*..
gi 254692966 1039 SLNLSRN 1045
Cdd:cd00116 311 SLWVKDD 317
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
861-1059 |
3.42e-13 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 74.06 E-value: 3.42e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 861 AEALVELFQKSPQLEEVNLSGNHLEDDGCRLVAEAASQLHIAQKLDLSDNGLSQTGVTYVLKAMSTCGTLEDLHISLlNN 940
Cdd:COG5238 225 AEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSV-NR 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 941 tvvLTFAqepreqegSCKGRAPLISFVSPVTSelsqrsrrIRLTHCGFLAKHTETLCEALRASCQTHNLDhldLSDNSLG 1020
Cdd:COG5238 304 ---IGDE--------GAIALAEGLQGNKTLHT--------LNLAYNGIGAQGAIALAKALQENTTLHSLD---LSDNQIG 361
|
170 180 190
....*....|....*....|....*....|....*....
gi 254692966 1021 GKGVILLTELLPGLGPLKSLNLSRNGLSMDAVFSLVQCL 1059
Cdd:COG5238 362 DEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDAL 400
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
848-1118 |
3.20e-11 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 66.61 E-value: 3.20e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 848 QLRLQKCQLRIRDAEALVELFQKSPQLEEVNLSGNHLE--DDGCRLVAEAASQLHIAQKLDLSDNGLSQTGVTyVLKAMS 925
Cdd:cd00116 27 VLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCG-VLESLL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 926 TCGTLEDLHisLLNNTvvLTFAQEPREQEGSCKGRAPLISFV-----------SPVTSELS--QRSRRIRLTHCGFLAKH 992
Cdd:cd00116 106 RSSSLQELK--LNNNG--LGDRGLRLLAKGLKDLPPALEKLVlgrnrlegascEALAKALRanRDLKELNLANNGIGDAG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 993 TETLCEALRASCqthNLDHLDLSDNSLGGKGVILLTELLPGLGPLKSLNLSRNGLSMDAVFSLVQCLSSLQWVFhLDVSL 1072
Cdd:cd00116 182 IRALAEGLKANC---NLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISL-LTLSL 257
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 254692966 1073 ESDCIFLRGAGTSRDALEPKFQtgVQVLELSQRYTSRSFCLQECQL 1118
Cdd:cd00116 258 SCNDITDDGAKDLAEVLAEKES--LLELDLRGNKFGEEGAQLLAES 301
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
517-632 |
2.09e-09 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 57.30 E-value: 2.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 517 HLSLQEFFAALYLMASHTVDKDTLV----------EYVTLNSHWVLRTKGRLglsDHLPAFLAGLASHTCHMFL-----C 581
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKSNPLkeffglrkreSLKSLLDKALKSKNGHL---DLFLRFLFGLLNEENQRLLegllgC 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 254692966 582 QLAQQDRAWvgsrqaaVIQVLRKLASRKLTGPKMIELYHCVAETQDLELAR 632
Cdd:pfam17776 78 KLSSEIKQE-------LLQWIKSLIQKELSSERFLNLFHCLYELQDESFVK 121
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1007-1307 |
2.85e-06 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 51.59 E-value: 2.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1007 HNLDHLDLSDNSLGGKGVILLTELLPGLGPLKSLNLSRNGLSMD--AVFSLVQCLSSLQWVFHLDVSlesDCIFLrgagt 1084
Cdd:cd00116 23 LCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIprGLQSLLQGLTKGCGLQELDLS---DNALG----- 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1085 srdalepkfQTGVQVLE-LSQRYTSRSFCLQECQLEPTSLTFLCAtlekspGPLEVQLSCKSLsddslkILLQCLpqlpq 1163
Cdd:cd00116 95 ---------PDGCGVLEsLLRSSSLQELKLNNNGLGDRGLRLLAK------GLKDLPPALEKL------VLGRNR----- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1164 lsllqlrhtvLSSRSPFLLADIFNLCPRVRKVTL----------RSLCHAVLHFdsneeQEGVCCGFPGCSLSQEHMETL 1233
Cdd:cd00116 149 ----------LEGASCEALAKALRANRDLKELNLanngigdagiRALAEGLKAN-----CNLEVLDLNNNGLTDEGASAL 213
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 254692966 1234 CCALSKCNALSQLDLTDNLLGDIGLRCLLECLPQLPIS-GWLDLSHNNISQEGILYLLETLPSYPNIQEVSVSLS 1307
Cdd:cd00116 214 AETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISlLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGN 288
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
1604-1672 |
2.96e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 43.28 E-value: 2.96e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254692966 1604 PELRKFDLSHNQIGDVGTQCLAailpKLPELRKFNLSHNQIGHVGTQCLAailpKLPELRKFDLSRNQI 1672
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFK----GLSNLKVLDLSNNLLTTLSPGAFS----GLPSLRYLDLSGNRL 61
|
|
| AvrBs3 |
NF041308 |
type III secretion system effector avirulence protein AvrBs3; |
1565-1767 |
1.11e-03 |
|
type III secretion system effector avirulence protein AvrBs3;
Pssm-ID: 469205 [Multi-domain] Cd Length: 1179 Bit Score: 44.18 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1565 LALLIQGLSRMTLLQDLCLSHNqigDVGTQCLAAILPKLPELRK--FDLSHNQIGDV-----GTQCLAAILPKLPELRK- 1636
Cdd:NF041308 665 LPVLCQRPHGLTPHQVVAIASN---DGGKQALETVQRLLPVLCQppYGLTPEQVVAIasnngGKQALETVQRLLPVLCQr 741
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1637 -FNLSHNQI----GHVG-TQCLAAILPKLPELRK--FDLSRNQI-----GDVGTQCLAAILPKLPELRK--FDLS----- 1696
Cdd:NF041308 742 pHGLTPDQVvaiaSNDGgKQALETVQRLLPVLCQppHGLTPDQVvaiasNDGGKQALETVQRLLPVLCDapHGLTphqvv 821
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1697 --GNRIGPAGGVQLVKSL------THFEHLEEIKLGNNALGEPTALELAQRLPPqlrVLCLPSSHLGPEGALGLA----- 1763
Cdd:NF041308 822 aiASNIGGRQALETVQRLlpvlcqAHGLTPDQVVAIASNNGGKQALETVQRLLP---VLCQPPHGLTPHQVVAIAsnigg 898
|
....*
gi 254692966 1764 -QALE 1767
Cdd:NF041308 899 kQALE 903
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1228-1311 |
1.66e-03 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 43.24 E-value: 1.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1228 EHMETLCCALSKCNALSQLDLTDNLLGDIGLRCLLECLPQLPISGWLDLSHNNISQEGILYLLETLPSYPNIQevSVSLS 1307
Cdd:COG5238 223 EGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLT--SLDLS 300
|
....
gi 254692966 1308 SEQI 1311
Cdd:COG5238 301 VNRI 304
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
746-789 |
4.95e-03 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 36.45 E-value: 4.95e-03
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 254692966 746 QLEEVSLHDNQLKDpevlslVELLPSLPKLQKLDLSRNSFSRSI 789
Cdd:pfam12799 2 NLEVLDLSNNQITD------IPPLAKLPNLETLDLSGNNKITDL 39
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
1630-1901 |
8.02e-03 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 41.37 E-value: 8.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1630 KLPELRKFNLSHNQIGhvgTQCLAAILPKLPELRKFDLSRNQigdvgtqcLAAILPK--LPELRKFDLSGNRIGPaggvQ 1707
Cdd:PLN00113 91 RLPYIQTINLSNNQLS---GPIPDDIFTTSSSLRYLNLSNNN--------FTGSIPRgsIPNLETLDLSNNMLSG----E 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1708 LVKSLTHFEHLEEIKLGNNALGEPTALELAQRlpPQLRVLCLPSSHLgpegALGLAQALEQCPHIEEVSLAENNLAGGVP 1787
Cdd:PLN00113 156 IPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNL--TSLEFLTLASNQL----VGQIPRELGQMKSLKWIYLGYNNLSGEIP 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1788 RFSKRLPLLRQIDLEFCKIEDQAARHLaANLT----LFPALEKL-------------LLSGNLLGDEVAAELAQVLPQMG 1850
Cdd:PLN00113 230 YEIGGLTSLNHLDLVYNNLTGPIPSSL-GNLKnlqyLFLYQNKLsgpippsifslqkLISLDLSDNSLSGEIPELVIQLQ 308
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 254692966 1851 QLKKVNLEWNRITARgaqlLAQGLVQGSCVPVIRLWNNPILNDVAQSLQSQ 1901
Cdd:PLN00113 309 NLEILHLFSNNFTGK----IPVALTSLPRLQVLQLWSNKFSGEIPKNLGKH 355
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Atypical_Card |
pfam18461 |
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts ... |
1-94 |
5.85e-48 |
|
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts a six alpha-helix bundle with a general death fold. Structure and sequence analysis of the NLRC5-N indicate that it possesses a fold similar to the one of the death-fold domains; however, it displays significant differences in the number of core alpha-helices and their relative orientation. Hence, it is suggested that NLRC5 belongs to the caspase recruitment domain (CARD) subfamily as an atypical CARD.
Pssm-ID: 436519 Cd Length: 95 Bit Score: 166.36 E-value: 5.85e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1 MDAESIRLNNENLWAWLVRLLSKNPEWLSAKLRSFLPTMDLDCSYEPSNP-EVIHRQLNRLFAQGMATWKSFINDLCFEL 79
Cdd:pfam18461 1 MDPESLQLGTENLWPWLVRLLSKNPEWLSAKVKFFLPNMDLGSSNEAPDPtQKVILQLDRLEAQGLATWQSFIHCVCMEL 80
|
90
....*....|....*
gi 254692966 80 DVPLDMEIPLVSIWG 94
Cdd:pfam18461 81 EVPLDLEVPLLSTWG 95
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1596-1905 |
2.56e-34 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 138.38 E-value: 2.56e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1596 LAAILPKLPELRKFDLSHNQIGDVGTQCL-AAILPKLPELRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRNQIGD 1674
Cdd:COG5238 143 LIQVLKDPLGGNAVHLLGLAARLGLLAAIsMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGD 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1675 VGTQCLAAILPKLPELRKFDLSGNRIGPAGGVQLVKSLTHFEHLEEIKLGNNALGEPTALELAQRL--PPQLRVLCLPSS 1752
Cdd:COG5238 223 EGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALqgNTTLTSLDLSVN 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1753 HLGPEGALGLAQALEQCPHIEEVSLAENNlaggvprfskrlpllrqidlefckIEDQAARHLAANLTLFPALEKLLLSGN 1832
Cdd:COG5238 303 RIGDEGAIALAEGLQGNKTLHTLNLAYNG------------------------IGAQGAIALAKALQENTTLHSLDLSDN 358
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254692966 1833 LLGDEVAAELAQVLPQMGQLKKVNLEWNRITARGAQLLAQGLvQGSCVPVIRLWNNPILNDVAQSLQSQEPRL 1905
Cdd:COG5238 359 QIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDAL-QTNRLHTLILDGNLIGAEAQQRLEQLLERI 430
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1520-1775 |
2.18e-33 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 135.69 E-value: 2.18e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1520 HHLEELDFSNNSLREEDTELLMGALQGTCRLKKLHLSFLPLGASSLALLIQGLSRMTLLQDLCLSHNQIGDVGTQCLAAI 1599
Cdd:COG5238 180 NSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1600 LPKLPELRKFDLSHNQIGDVGTQCLAAILPKLPELRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRNQIGDVGTQC 1679
Cdd:COG5238 260 LKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIA 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1680 LAAILPKLPELRKFDLSGNRIGPAGGVQLVKSLTHFEHLEEIKLGNNALGEPTALELAQRL-PPQLRVLCLPSSHLGPEG 1758
Cdd:COG5238 340 LAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALqTNRLHTLILDGNLIGAEA 419
|
250
....*....|....*..
gi 254692966 1759 AlglAQALEQCPHIEEV 1775
Cdd:COG5238 420 Q---QRLEQLLERIKSV 433
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1520-1782 |
4.67e-31 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 125.55 E-value: 4.67e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1520 HHLEELDFSNNSLREEDTELLMGALQGTCRLKKLHLSFLPLGAS--SLALLIQGLSRMTLLQDLCLSHNQIGDVGTQCLA 1597
Cdd:cd00116 23 LCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIprGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLE 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1598 AILpKLPELRKFDLSHNQIGDVGTQCLAAILPKLPE-LRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRNQIGDVG 1676
Cdd:cd00116 103 SLL-RSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1677 TQCLAAILPKLPELRKFDLSGNRIGPAGGVQLVKSLTHFEHLEEIKLGNNALGEPTALELAQRLP---PQLRVLCLPSSH 1753
Cdd:cd00116 182 IRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLspnISLLTLSLSCND 261
|
250 260
....*....|....*....|....*....
gi 254692966 1754 LGPEGALGLAQALEQCPHIEEVSLAENNL 1782
Cdd:cd00116 262 ITDDGAKDLAEVLAEKESLLELDLRGNKF 290
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
223-385 |
1.02e-30 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 119.72 E-value: 1.02e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 223 RVTVLLGKAGMGKTTLAYRLRWRWAQGQLDR-FQALFLFEFRQLNMITQLPTLPQLLFDLYLMPESEPDAVFQYLKENAQ 301
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQgFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 302 EVLLIFDGLDEALHADSVgTDNAGSALTLFSELCHGNLLPGCWVMTTSRPG---KLPSCVPtEAATVHMWGFDGLRVEKY 378
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQ-LDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalrDLRRGLE-EPRYLEVRGFSESDRKQY 158
|
....*..
gi 254692966 379 VTCFFSD 385
Cdd:pfam05729 159 VRKYFSD 165
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1522-1768 |
3.81e-28 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 117.07 E-value: 3.81e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1522 LEELDFSNNSLREED--TELLMGALQGTCRLKKLHLSFLPLGASSLALLiQGLSRMTLLQDLCLSHNQIGDVGTQCLAAI 1599
Cdd:cd00116 53 LKELCLSLNETGRIPrgLQSLLQGLTKGCGLQELDLSDNALGPDGCGVL-ESLLRSSSLQELKLNNNGLGDRGLRLLAKG 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1600 LPKLPE-LRKFDLSHNQIGDVGTQCLAAILPKLPELRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRNQIGDVGTQ 1678
Cdd:cd00116 132 LKDLPPaLEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGAS 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1679 CLAAILPKLPELRKFDLSGNRIGPAGGVQLVKSLTHFEH-LEEIKLGNNALGEPTALELAQRLP--PQLRVLCLPSSHLG 1755
Cdd:cd00116 212 ALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNIsLLTLSLSCNDITDDGAKDLAEVLAekESLLELDLRGNKFG 291
|
250
....*....|...
gi 254692966 1756 PEGALGLAQALEQ 1768
Cdd:cd00116 292 EEGAQLLAESLLE 304
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1578-1887 |
1.57e-27 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 115.53 E-value: 1.57e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1578 LQDLCLSHNQIGDVGTQCLAAILPKLPELRKFDLSHNQIG--DVGTQCLAAILPKLPELRKFNLSHNQIGHVGTQCLAAI 1655
Cdd:cd00116 25 LQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1656 LpKLPELRKFDLSRNQIGDVGTQCLAAILPKLPE-LRKFDLSGNRIGPAGGVQLVKSLTHFEHLEEIKLGNNALGEPTAL 1734
Cdd:cd00116 105 L-RSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIR 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1735 ELAQRLP--PQLRVLCLPSSHLGPEGALGLAQALEQcphieevslaennlaggvprfskrLPLLRQIDLEFCKIEDQAAR 1812
Cdd:cd00116 184 ALAEGLKanCNLEVLDLNNNGLTDEGASALAETLAS------------------------LKSLEVLNLGDNNLTDAGAA 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254692966 1813 HLA-ANLTLFPALEKLLLSGNLLGDEVAAELAQVLPQMGQLKKVNLEWNRITARGAQLLAQGLVQGSCVPvIRLWN 1887
Cdd:cd00116 240 ALAsALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNEL-ESLWV 314
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1445-1716 |
2.95e-26 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 114.12 E-value: 2.95e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1445 LETEHSHLMIQLVETYARLQQLSLSQVSFNDN--DGTSSKLLQNILLSSCELKSFRLTFSQVSTKSLTHLAFGLGHCHHL 1522
Cdd:COG5238 159 LGLAARLGLLAAISMAKALQNNSVETVYLGCNqiGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSL 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1523 EELDFSNNSLREEDTELLMGALQGTCRLKKLHLSFLPLGASSLALLIQGLSRMTLLQDLCLSHNQIGDVGTQCLAAILPK 1602
Cdd:COG5238 239 TTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQG 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1603 LPELRKFDLSHNQIGDVGTQCLAAILPKLPELRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRNQIGDVGTQCLAA 1682
Cdd:COG5238 319 NKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALID 398
|
250 260 270
....*....|....*....|....*....|....
gi 254692966 1683 ILpKLPELRKFDLSGNRIGPAGGVQLVKSLTHFE 1716
Cdd:COG5238 399 AL-QTNRLHTLILDGNLIGAEAQQRLEQLLERIK 431
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1437-1684 |
1.86e-25 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 109.37 E-value: 1.86e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1437 ALRLAHCDLETEHS----HLMIQLVETYARLQQLSLSQVSFNDndgTSSKLLQNILLSScELKSFRLTFSQVSTKSLTHL 1512
Cdd:cd00116 53 LKELCLSLNETGRIprglQSLLQGLTKGCGLQELDLSDNALGP---DGCGVLESLLRSS-SLQELKLNNNGLGDRGLRLL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1513 AFGLGHC-HHLEELDFSNNSLREEDTELLMGALQGTCRLKKLHLSFLPLGASSLALLIQGLSRMTLLQDLCLSHNQIGDV 1591
Cdd:cd00116 129 AKGLKDLpPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDE 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1592 GTQCLAAILPKLPELRKFDLSHNQIGDVGTQCLAAILPKL-PELRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRN 1670
Cdd:cd00116 209 GASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPnISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGN 288
|
250
....*....|....
gi 254692966 1671 QIGDVGTQCLAAIL 1684
Cdd:cd00116 289 KFGEEGAQLLAESL 302
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
223-673 |
4.49e-22 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 104.12 E-value: 4.49e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 223 RVTVLLGKAGMGKTTLAYRLRWRWAQGQLDRFQAL-FLFEFRQLNmitQLPTLPQLLFDLYLMPESEPDAVFQYLKENAQ 301
Cdd:COG5635 181 KRLLILGEPGSGKTTLLRYLALELAERYLDAEDPIpILIELRDLA---EEASLEDLLAEALEKRGGEPEDALERLLRNGR 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 302 eVLLIFDGLDEAlhADSVGTDNAGSALTLFSELChgnllPGCWVMTTSRPGKLPSCVPTEAATVHMWGFDGLRVEKYVTC 381
Cdd:COG5635 258 -LLLLLDGLDEV--PDEADRDEVLNQLRRFLERY-----PKARVIITSRPEGYDSSELEGFEVLELAPLSDEQIEEFLKK 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 382 FFSDLLSQ-ELALKEMRTNARLRGMCAIPALCTVTCFCLRrllpgsspgQSAALLPTITQLYLQMVETF---------SP 451
Cdd:COG5635 330 WFEATERKaERLLEALEENPELRELARNPLLLTLLALLLR---------ERGELPDTRAELYEQFVELLlerwdeqrgLT 400
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 452 SETLLDTSILG--FGKVALRGLDTGKVVFSVED----ISPQLMSFGAVHSLLTSFCIHT----RPGHEEigYAFVHLSLQ 521
Cdd:COG5635 401 IYRELSREELRelLSELALAMQENGRTEFAREEleeiLREYLGRRKDAEALLDELLLRTgllvERGEGR--YSFAHRSFQ 478
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 522 EFFAALYLMASHTVD-KDTLVEYVTlNSHW--VLRtkgrlglsdhlpaFLAGLASHTCHM--FLCQLAQQDRAWVGSRQA 596
Cdd:COG5635 479 EYLAARALVEELDEElLELLAEHLE-DPRWreVLL-------------LLAGLLDDVKQIkeLIDALLARDDAAALALAA 544
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 254692966 597 AVIQVLRKLASRKLTGPKMIELYHCVAETQDLELARFTAQSLPSRLSFHNFPLTHADLAALANILEHRDDPIHLDFD 673
Cdd:COG5635 545 ALLLALLLALALLALLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLLLLLLLLLLLLLLALALL 621
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1627-1898 |
2.91e-21 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 97.04 E-value: 2.91e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1627 ILPKLPELRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRNQIG--DVGTQCLAAILPKLPELRKFDLSGNRIGPAG 1704
Cdd:cd00116 18 LLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTKGCGLQELDLSDNALGPDG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1705 gVQLVKSLTHFEHLEEIKLGNNALGePTALELAQR----LPPQLRVLCLPSSHLGPEGALGLAQALEQCPHIEEVSLAEN 1780
Cdd:cd00116 98 -CGVLESLLRSSSLQELKLNNNGLG-DRGLRLLAKglkdLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANN 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1781 NlaggvprfskrlpllrqidlefckIEDQAARHLAANLTLFPALEKLLLSGNLLGDEVAAELAQVLPQMGQLKKVNLEWN 1860
Cdd:cd00116 176 G------------------------IGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDN 231
|
250 260 270
....*....|....*....|....*....|....*....
gi 254692966 1861 RITARGAQLLAQGLVQGS-CVPVIRLWNNPILNDVAQSL 1898
Cdd:cd00116 232 NLTDAGAAALASALLSPNiSLLTLSLSCNDITDDGAKDL 270
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1408-1758 |
4.91e-17 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 85.76 E-value: 4.91e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1408 LTELSISEIQRKLWLQLEFPHQEGNSDSMALRLAHCDLETEHSHLMIQLVETYARLQQLSLSQVSFNDNDGTSS-KLLQN 1486
Cdd:COG4886 38 LLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNlTNLES 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1487 ILLSSCELKSFRLTFSQ--------VSTKSLTHLAFGLGHCHHLEELDFSNNSLREEDTELlmGALQgtcRLKKLHLSFL 1558
Cdd:COG4886 118 LDLSGNQLTDLPEELANltnlkeldLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEEL--GNLT---NLKELDLSNN 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1559 PLgaSSLALLIQGLSRmtlLQDLCLSHNQIGDvgtqcLAAILPKLPELRKFDLSHNQIGDVgtqclaAILPKLPELRKFN 1638
Cdd:COG4886 193 QI--TDLPEPLGNLTN---LEELDLSGNQLTD-----LPEPLANLTNLETLDLSNNQLTDL------PELGNLTNLEELD 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1639 LSHNQIGHVGTqclaaiLPKLPELRKFDLSRNQIGDVGTQCLAAILPKLPELRKFDLSGNRIGPAGGVQLVKSLTHFEHL 1718
Cdd:COG4886 257 LSNNQLTDLPP------LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLL 330
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 254692966 1719 EEIKLGNNALGEPTALELAQRLPPQLRVLCLPSSHLGPEG 1758
Cdd:COG4886 331 KGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLG 370
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
640-936 |
6.58e-15 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 79.45 E-value: 6.58e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 640 SRLSFHNFPLTHADLAALANILEHRDDPI--HLDFDGCP-----LEPHCPEALVGCGQVENLSFKSRKCGDAFAEALCRS 712
Cdd:COG5238 124 AKTLEDSLILYLALPRRINLIQVLKDPLGgnAVHLLGLAarlglLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEA 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 713 LPTMGSLKTLGLTGSRITAQGISHLIQTLPLCSQLEEVSLHDNQLKDPEVLSLVELLPSLPKLQKLDLSRNSfsrsills 792
Cdd:COG5238 204 LTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQ-------- 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 793 lvkvaITCPTVRKLqvreldlifylspvtetatqqsgASDVQGKDSLKegqsrSLQLRLQkcQLRIRDAEALVELFQKSP 872
Cdd:COG5238 276 -----IGAEGAIAL-----------------------AKALQGNTTLT-----SLDLSVN--RIGDEGAIALAEGLQGNK 320
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254692966 873 QLEEVNLSGNHLEDDGCRLVAEAASQLHIAQKLDLSDNGLSQTGVTYVLKAMSTCGTLEDLHIS 936
Cdd:COG5238 321 TLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLG 384
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1522-1915 |
1.86e-14 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 77.67 E-value: 1.86e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1522 LEELDFSNNSLREEDTELLMGALQGTCRLKKLHLSFLPLGASSLALLIQGLSRMTLLQDLCLSHNQIGDVGTQCLAAILP 1601
Cdd:COG4886 14 LLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1602 KLPELRKFDLSHNQIgdvgtqclaaiLPKLPELRKFNLSHNQIGHvgtqcLAAILPKLPELRKFDLSRNQIGDVGTQcla 1681
Cdd:COG4886 94 DLTNLTELDLSGNEE-----------LSNLTNLESLDLSGNQLTD-----LPEELANLTNLKELDLSNNQLTDLPEP--- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1682 aiLPKLPELRKFDLSGNRIGpaggvQLVKSLTHFEHLEEIKLGNNALGEptalelaqrlppqlrvlclpsshlgpegalg 1761
Cdd:COG4886 155 --LGNLTNLKSLDLSNNQLT-----DLPEELGNLTNLKELDLSNNQITD------------------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1762 LAQALEQCPHIEEVSLAENNLAGgVPRFSKRLPLLRQIDLEFCKIEDqaarhlAANLTLFPALEKLLLSGNLLGDevaae 1841
Cdd:COG4886 197 LPEPLGNLTNLEELDLSGNQLTD-LPEPLANLTNLETLDLSNNQLTD------LPELGNLTNLEELDLSNNQLTD----- 264
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 254692966 1842 laqvLP---QMGQLKKVNLEWNRITARGAQLLAQGLVQGSCVPVIRLWNNPILNDVAQSLQSQEPRLDFSITDQQTL 1915
Cdd:COG4886 265 ----LPplaNLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTL 337
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
735-1045 |
1.61e-13 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 73.54 E-value: 1.61e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 735 SHLIQTLPLCSQLEEVSLHDNQLKDPEVLSLVELLPSLPKLQKLDLSRNSFSRS--ILLSLVKVAITCPTVRKLQVRELD 812
Cdd:cd00116 13 ERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIprGLQSLLQGLTKGCGLQELDLSDNA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 813 LIFYLSPVTETATQ----------QSGASDVQGK---DSLKEGQSRSLQLRLQKCQLRIRDAEALVELFQKSPQLEEVNL 879
Cdd:cd00116 93 LGPDGCGVLESLLRssslqelklnNNGLGDRGLRllaKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 880 SGNHLEDDGCRLVAEAASQLHIAQKLDLSDNGLSQTGVTYVLKAMSTCGTLEDLHIsllnntvvltfaqepreqeGSCKG 959
Cdd:cd00116 173 ANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNL-------------------GDNNL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 960 RAPLISFVSPVTSELSQRSRRIRLTHCGFLAKHTETLCEALRASCQthnLDHLDLSDNSLGGKGVILLTELLPGLGP-LK 1038
Cdd:cd00116 234 TDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKES---LLELDLRGNKFGEEGAQLLAESLLEPGNeLE 310
|
....*..
gi 254692966 1039 SLNLSRN 1045
Cdd:cd00116 311 SLWVKDD 317
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
861-1059 |
3.42e-13 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 74.06 E-value: 3.42e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 861 AEALVELFQKSPQLEEVNLSGNHLEDDGCRLVAEAASQLHIAQKLDLSDNGLSQTGVTYVLKAMSTCGTLEDLHISLlNN 940
Cdd:COG5238 225 AEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSV-NR 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 941 tvvLTFAqepreqegSCKGRAPLISFVSPVTSelsqrsrrIRLTHCGFLAKHTETLCEALRASCQTHNLDhldLSDNSLG 1020
Cdd:COG5238 304 ---IGDE--------GAIALAEGLQGNKTLHT--------LNLAYNGIGAQGAIALAKALQENTTLHSLD---LSDNQIG 361
|
170 180 190
....*....|....*....|....*....|....*....
gi 254692966 1021 GKGVILLTELLPGLGPLKSLNLSRNGLSMDAVFSLVQCL 1059
Cdd:COG5238 362 DEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDAL 400
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
611-895 |
3.19e-12 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 69.69 E-value: 3.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 611 TGPKMIELYHCVAETQDLELARFtaQSLPSRLSFHNFPLTHADLaalanilehrdDPIHLDFDGCPLePHCPEAL--VGC 688
Cdd:cd00116 79 KGCGLQELDLSDNALGPDGCGVL--ESLLRSSSLQELKLNNNGL-----------GDRGLRLLAKGL-KDLPPALekLVL 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 689 GQvenlsfksRKCGDAFAEALCRSLPTMGSLKTLGLTGSRITAQGISHLIQTLPLCSQLEEVSLHDNQLKDPEVLSLVEL 768
Cdd:cd00116 145 GR--------NRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAET 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 769 LPSLPKLQKLDLSRNSFSRSILLSLvkvaitcptvrklqvreldlifylspvtetatqqsgasdvqgKDSLKEGQSRSLQ 848
Cdd:cd00116 217 LASLKSLEVLNLGDNNLTDAGAAAL------------------------------------------ASALLSPNISLLT 254
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 254692966 849 LRLQKCQLRIRDAEALVELFQKSPQLEEVNLSGNHLEDDGCRLVAEA 895
Cdd:cd00116 255 LSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAES 301
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1463-1747 |
5.83e-12 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 69.96 E-value: 5.83e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1463 LQQLSLSQVSFNDNDGTSSKL--LQNILLSSCELKSFRLTFSQ--------VSTKSLTHLAFGLGHCHHLEELDFSNNSL 1532
Cdd:COG4886 115 LESLDLSGNQLTDLPEELANLtnLKELDLSNNQLTDLPEPLGNltnlksldLSNNQLTDLPEELGNLTNLKELDLSNNQI 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1533 REEDTELlmGALQgtcRLKKLHLSflplgASSLALLIQGLSRMTLLQDLCLSHNQIGDVgtqclaAILPKLPELRKFDLS 1612
Cdd:COG4886 195 TDLPEPL--GNLT---NLEELDLS-----GNQLTDLPEPLANLTNLETLDLSNNQLTDL------PELGNLTNLEELDLS 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1613 HNQIGDVGTqclaaiLPKLPELRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRNQIGDVGTQCLAAILPKLPELRK 1692
Cdd:COG4886 259 NNQLTDLPP------LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKG 332
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 254692966 1693 FDLSGNRIGPAGGVQLVKSLTHFEHLEEIKLGNNALGEPTALELAQRLPPQLRVL 1747
Cdd:COG4886 333 LLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLL 387
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
848-1118 |
3.20e-11 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 66.61 E-value: 3.20e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 848 QLRLQKCQLRIRDAEALVELFQKSPQLEEVNLSGNHLE--DDGCRLVAEAASQLHIAQKLDLSDNGLSQTGVTyVLKAMS 925
Cdd:cd00116 27 VLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCG-VLESLL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 926 TCGTLEDLHisLLNNTvvLTFAQEPREQEGSCKGRAPLISFV-----------SPVTSELS--QRSRRIRLTHCGFLAKH 992
Cdd:cd00116 106 RSSSLQELK--LNNNG--LGDRGLRLLAKGLKDLPPALEKLVlgrnrlegascEALAKALRanRDLKELNLANNGIGDAG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 993 TETLCEALRASCqthNLDHLDLSDNSLGGKGVILLTELLPGLGPLKSLNLSRNGLSMDAVFSLVQCLSSLQWVFhLDVSL 1072
Cdd:cd00116 182 IRALAEGLKANC---NLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISL-LTLSL 257
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 254692966 1073 ESDCIFLRGAGTSRDALEPKFQtgVQVLELSQRYTSRSFCLQECQL 1118
Cdd:cd00116 258 SCNDITDDGAKDLAEVLAEKES--LLELDLRGNKFGEEGAQLLAES 301
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1507-1700 |
1.55e-10 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 62.88 E-value: 1.55e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1507 KSLTHLAF---------GLGHCHHLEELDFSNNSLREedtellMGALQGTCRLKKLHLS--FLplgaSSlallIQGLSRM 1575
Cdd:cd21340 2 KRITHLYLndknitkidNLSLCKNLKVLYLYDNKITK------IENLEFLTNLTHLYLQnnQI----EK----IENLENL 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1576 TLLQDLCLSHNQIGDV-GtqclaaiLPKLPELRKFDLSHNQIGD-----VGTQCLAAIlpkLPELRKFNLSHNQIghvgt 1649
Cdd:cd21340 68 VNLKKLYLGGNRISVVeG-------LENLTNLEELHIENQRLPPgekltFDPRSLAAL---SNSLRVLNISGNNI----- 132
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 254692966 1650 QCLAAILPkLPELRKFDLSRNQIGDVgtQCLAAILPKLPELRKFDLSGNRI 1700
Cdd:cd21340 133 DSLEPLAP-LRNLEQLDASNNQISDL--EELLDLLSSWPSLRELDLTGNPV 180
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
847-1156 |
7.38e-10 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 62.37 E-value: 7.38e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 847 LQLRLQKCQLRIRDAEalvELFQKSPQLEEVNLSGNHLEDDGCRLVAEAASQLHIAQKLDLSDN--GLSQTGVTYVLKAM 924
Cdd:cd00116 1 LQLSLKGELLKTERAT---ELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNetGRIPRGLQSLLQGL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 925 STCGTLEdlHISLLNNTvvLTFAqepreqegsckGRAPLISFVSPVTSELSQrsrrirLTHCGFLAKHTETLCEALRaSC 1004
Cdd:cd00116 78 TKGCGLQ--ELDLSDNA--LGPD-----------GCGVLESLLRSSSLQELK------LNNNGLGDRGLRLLAKGLK-DL 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1005 QtHNLDHLDLSDNSLGGKGVILLTELLPGLGPLKSLNLSRNGLSMDAVFSLVQCLSSLQWVFHLDvsLESDCIFLRGAGT 1084
Cdd:cd00116 136 P-PALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLD--LNNNGLTDEGASA 212
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 254692966 1085 SRDALEPKFQtgVQVLELSQrytsrsfCLqeCQLEPTSlTFLCATLEKSPGPLEVQLSCKSLSDDSLKILLQ 1156
Cdd:cd00116 213 LAETLASLKS--LEVLNLGD-------NN--LTDAGAA-ALASALLSPNISLLTLSLSCNDITDDGAKDLAE 272
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
683-926 |
8.42e-10 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 63.27 E-value: 8.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 683 EALVGCGQVENLSFKSRKCGDAFAEALCRSLPTMGSLKTLGLTGSRITAQGISHLIQTLPLCSQLEEVSLHDNQLKDPEV 762
Cdd:COG5238 230 EALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGA 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 763 LSLVELLPSLPKLQKLDLSRNsfsrsillslvkvaitcptvrklqvreldlifylspvtetatqqsgasdvqgkdslkeg 842
Cdd:COG5238 310 IALAEGLQGNKTLHTLNLAYN----------------------------------------------------------- 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 843 qsrslqlrlqkcQLRIRDAEALVELFQKSPQLEEVNLSGNHLEDDGCRLVAEA---ASQLHiaqKLDLSDNGLSQTGVTY 919
Cdd:COG5238 331 ------------GIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYlegNTTLR---ELNLGKNNIGKQGAEA 395
|
....*..
gi 254692966 920 VLKAMST 926
Cdd:COG5238 396 LIDALQT 402
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
843-1071 |
9.68e-10 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 62.89 E-value: 9.68e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 843 QSRSLQLRLQKCQLRiRDAEALVELFQKSPQLEEVNLSGNHLEDDGCRLVAEAASQLHIAQKLDLSDNGLSQTGVTYVLK 922
Cdd:COG5238 152 GGNAVHLLGLAARLG-LLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAE 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 923 AMSTCGTLEDLHISllNNTVvltfaqepreqegSCKGRAPLIsfvspvtsELSQRSRRIR---LTHCGFLAKHTETLCEA 999
Cdd:COG5238 231 ALKGNKSLTTLDLS--NNQI-------------GDEGVIALA--------EALKNNTTVEtlyLSGNQIGAEGAIALAKA 287
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 254692966 1000 LRASCQTHNLDhldLSDNSLGGKGVILLTELLPGLGPLKSLNLSRNGLSMDAVFSLVQCLSSLQWVFHLDVS 1071
Cdd:COG5238 288 LQGNTTLTSLD---LSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLS 356
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
517-632 |
2.09e-09 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 57.30 E-value: 2.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 517 HLSLQEFFAALYLMASHTVDKDTLV----------EYVTLNSHWVLRTKGRLglsDHLPAFLAGLASHTCHMFL-----C 581
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKSNPLkeffglrkreSLKSLLDKALKSKNGHL---DLFLRFLFGLLNEENQRLLegllgC 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 254692966 582 QLAQQDRAWvgsrqaaVIQVLRKLASRKLTGPKMIELYHCVAETQDLELAR 632
Cdd:pfam17776 78 KLSSEIKQE-------LLQWIKSLIQKELSSERFLNLFHCLYELQDESFVK 121
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1007-1307 |
2.85e-06 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 51.59 E-value: 2.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1007 HNLDHLDLSDNSLGGKGVILLTELLPGLGPLKSLNLSRNGLSMD--AVFSLVQCLSSLQWVFHLDVSlesDCIFLrgagt 1084
Cdd:cd00116 23 LCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIprGLQSLLQGLTKGCGLQELDLS---DNALG----- 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1085 srdalepkfQTGVQVLE-LSQRYTSRSFCLQECQLEPTSLTFLCAtlekspGPLEVQLSCKSLsddslkILLQCLpqlpq 1163
Cdd:cd00116 95 ---------PDGCGVLEsLLRSSSLQELKLNNNGLGDRGLRLLAK------GLKDLPPALEKL------VLGRNR----- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1164 lsllqlrhtvLSSRSPFLLADIFNLCPRVRKVTL----------RSLCHAVLHFdsneeQEGVCCGFPGCSLSQEHMETL 1233
Cdd:cd00116 149 ----------LEGASCEALAKALRANRDLKELNLanngigdagiRALAEGLKAN-----CNLEVLDLNNNGLTDEGASAL 213
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 254692966 1234 CCALSKCNALSQLDLTDNLLGDIGLRCLLECLPQLPIS-GWLDLSHNNISQEGILYLLETLPSYPNIQEVSVSLS 1307
Cdd:cd00116 214 AETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISlLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGN 288
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
1604-1672 |
2.96e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 43.28 E-value: 2.96e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254692966 1604 PELRKFDLSHNQIGDVGTQCLAailpKLPELRKFNLSHNQIGHVGTQCLAailpKLPELRKFDLSRNQI 1672
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFK----GLSNLKVLDLSNNLLTTLSPGAFS----GLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
1632-1700 |
8.71e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 42.13 E-value: 8.71e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254692966 1632 PELRKFNLSHNQIGHVGTQCLAailpKLPELRKFDLSRNQIGDVGTQCLAailpKLPELRKFDLSGNRI 1700
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFK----GLSNLKVLDLSNNLLTTLSPGAFS----GLPSLRYLDLSGNRL 61
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
707-944 |
4.59e-04 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 44.92 E-value: 4.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 707 EALCRSLPTMGSLKTLGLTGSRITaqgisHLIQTLPLCSQLEEVSLHDNQLKD-PEVLSlvellpSLPKLQKLDLSRNSF 785
Cdd:COG4886 126 TDLPEELANLTNLKELDLSNNQLT-----DLPEPLGNLTNLKSLDLSNNQLTDlPEELG------NLTNLKELDLSNNQI 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 786 SrSILLSLVKvaitCPTVRKL-----QVRELDLIFylspvtetatqqsgasdvqgkdslkeGQSRSLQ-LRLQKCQlrIR 859
Cdd:COG4886 195 T-DLPEPLGN----LTNLEELdlsgnQLTDLPEPL--------------------------ANLTNLEtLDLSNNQ--LT 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 860 DAEALVELfqksPQLEEVNLSGNHLEDdgcrlvAEAASQLHIAQKLDLSDNGLSQTGVTYVLKAMSTCGTLEDLHISLLN 939
Cdd:COG4886 242 DLPELGNL----TNLEELDLSNNQLTD------LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLL 311
|
....*
gi 254692966 940 NTVVL 944
Cdd:COG4886 312 ELLIL 316
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
710-913 |
8.46e-04 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 44.15 E-value: 8.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 710 CRSLPTMGSLKTLGLTGSRITaqgisHLIQTLPLCSQLEEVSLHDNQLKDpevlsLVELLPSLPKLQKLDLSRNSFSrsi 789
Cdd:COG4886 106 NEELSNLTNLESLDLSGNQLT-----DLPEELANLTNLKELDLSNNQLTD-----LPEPLGNLTNLKSLDLSNNQLT--- 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 790 llSLVKVAITCPTVRKLQVRELDLifylspvtetatqqsgasdvqgkDSLKE--GQSRSLQ-LRLQKCQLrirdaEALVE 866
Cdd:COG4886 173 --DLPEELGNLTNLKELDLSNNQI-----------------------TDLPEplGNLTNLEeLDLSGNQL-----TDLPE 222
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 254692966 867 LFQKSPQLEEVNLSGNHLEDdgcrlvAEAASQLHIAQKLDLSDNGLS 913
Cdd:COG4886 223 PLANLTNLETLDLSNNQLTD------LPELGNLTNLEELDLSNNQLT 263
|
|
| AvrBs3 |
NF041308 |
type III secretion system effector avirulence protein AvrBs3; |
1565-1767 |
1.11e-03 |
|
type III secretion system effector avirulence protein AvrBs3;
Pssm-ID: 469205 [Multi-domain] Cd Length: 1179 Bit Score: 44.18 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1565 LALLIQGLSRMTLLQDLCLSHNqigDVGTQCLAAILPKLPELRK--FDLSHNQIGDV-----GTQCLAAILPKLPELRK- 1636
Cdd:NF041308 665 LPVLCQRPHGLTPHQVVAIASN---DGGKQALETVQRLLPVLCQppYGLTPEQVVAIasnngGKQALETVQRLLPVLCQr 741
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1637 -FNLSHNQI----GHVG-TQCLAAILPKLPELRK--FDLSRNQI-----GDVGTQCLAAILPKLPELRK--FDLS----- 1696
Cdd:NF041308 742 pHGLTPDQVvaiaSNDGgKQALETVQRLLPVLCQppHGLTPDQVvaiasNDGGKQALETVQRLLPVLCDapHGLTphqvv 821
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1697 --GNRIGPAGGVQLVKSL------THFEHLEEIKLGNNALGEPTALELAQRLPPqlrVLCLPSSHLGPEGALGLA----- 1763
Cdd:NF041308 822 aiASNIGGRQALETVQRLlpvlcqAHGLTPDQVVAIASNNGGKQALETVQRLLP---VLCQPPHGLTPHQVVAIAsnigg 898
|
....*
gi 254692966 1764 -QALE 1767
Cdd:NF041308 899 kQALE 903
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
669-921 |
1.64e-03 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 43.00 E-value: 1.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 669 HLDFDGCPLEpHCPEALVGCGQVENLSFKSRKCGDaFAEALCRslptMGSLKTLGLTGSRITAqgishLIQTLPLCSQLE 748
Cdd:COG4886 163 SLDLSNNQLT-DLPEELGNLTNLKELDLSNNQITD-LPEPLGN----LTNLEELDLSGNQLTD-----LPEPLANLTNLE 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 749 EVSLHDNQLKDPEVLSlvellpSLPKLQKLDLSRNSFSR----SILLSLVKVAITCPTVRKLQVRELDLIFYLSPVTETA 824
Cdd:COG4886 232 TLDLSNNQLTDLPELG------NLTNLEELDLSNNQLTDlpplANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLL 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 825 TQQSGASDVQGKDSLKEGQSRSLQLRLQKCQLRIRDAEALVELFQKSPQLEEVNLSGNHLEDDGCRLVAEAASQLHIAQK 904
Cdd:COG4886 306 LLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALL 385
|
250
....*....|....*..
gi 254692966 905 LDLSDNGLSQTGVTYVL 921
Cdd:COG4886 386 LLTLLLLLLTTTAGVLL 402
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1228-1311 |
1.66e-03 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 43.24 E-value: 1.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1228 EHMETLCCALSKCNALSQLDLTDNLLGDIGLRCLLECLPQLPISGWLDLSHNNISQEGILYLLETLPSYPNIQevSVSLS 1307
Cdd:COG5238 223 EGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLT--SLDLS 300
|
....
gi 254692966 1308 SEQI 1311
Cdd:COG5238 301 VNRI 304
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1225-1358 |
2.09e-03 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 42.85 E-value: 2.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1225 LSQEHMETLCCALSKCNALSQLDLTDNLLGDIGLRCLLECLPQLPISGWLDLSHNNISQEGILYLLETLPSYPNIqevsv 1304
Cdd:COG5238 276 IGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTL----- 350
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 254692966 1305 slsseqifrmcfskkegagTSLRLCECSFSPEQVSKLASSLSQAQQLTELWLTK 1358
Cdd:COG5238 351 -------------------HSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGK 385
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
1578-1644 |
2.39e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 37.89 E-value: 2.39e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 254692966 1578 LQDLCLSHNQIGDVGTQCLAailpKLPELRKFDLSHNQIGDVGTQCLAailpKLPELRKFNLSHNQI 1644
Cdd:pfam13855 3 LRSLDLSNNRLTSLDDGAFK----GLSNLKVLDLSNNLLTTLSPGAFS----GLPSLRYLDLSGNRL 61
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1201-1687 |
2.42e-03 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 42.47 E-value: 2.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1201 CHAVLHFDSNEEQEGVCCGfpGCSLSQEHMETLCCALSKCNALSQLDLTDNLLGDIGLRCLLECLPQLPISGWLDLSHNN 1280
Cdd:COG5238 170 AISMAKALQNNSVETVYLG--CNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQ 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1281 ISQEGILYLLETLPSypniqevsvslsseqifrmcfskkegaGTSLRlcecsfspeqvsklasslsqaqqltelwltkcH 1360
Cdd:COG5238 248 IGDEGVIALAEALKN---------------------------NTTVE--------------------------------T 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1361 LDLpqltmllnlvnrptgllglrleepwvdsvslpalmevcaqasgcltelsiseiqrklwlqlefphqEGNsdsmalrl 1440
Cdd:COG5238 269 LYL------------------------------------------------------------------SGN-------- 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1441 ahcdletehshlmiqlvetyarlqqlslsqvsfndndgtsskllqnillsscelksfrltfsQVSTKSLTHLAFGLGHCH 1520
Cdd:COG5238 275 --------------------------------------------------------------QIGAEGAIALAKALQGNT 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1521 HLEELDFSNNSLREEdtellmgalqgtcrlkklhlsflplGASSLAlliQGLSRMTLLQDLCLSHNQIGDVGTQCLAAIL 1600
Cdd:COG5238 293 TLTSLDLSVNRIGDE-------------------------GAIALA---EGLQGNKTLHTLNLAYNGIGAQGAIALAKAL 344
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1601 PKLPELRKFDLSHNQIGDVGTQCLAAILPKLPELRKFNLSHNQIGHVGTQCLAAILpKLPELRKFDLSRNQIGDVGTQCL 1680
Cdd:COG5238 345 QENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDAL-QTNRLHTLILDGNLIGAEAQQRL 423
|
....*..
gi 254692966 1681 AAILPKL 1687
Cdd:COG5238 424 EQLLERI 430
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
987-1293 |
3.78e-03 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 42.08 E-value: 3.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 987 GFLAKHTETLCEALRASCQTHNLDHLDLSDNSLGGKGVILLTELLPGLGPLKSLNLSRNGLSMDAVFSLVQCLSSLQWVF 1066
Cdd:COG5238 160 GLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLT 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1067 HLDVSleSDCIFLRGAGTSRDALepKFQTGVQVLELSQRytsrsfclqecQLEPTSLTFLCATLEKSPGPLEVQLSCKSL 1146
Cdd:COG5238 240 TLDLS--NNQIGDEGVIALAEAL--KNNTTVETLYLSGN-----------QIGAEGAIALAKALQGNTTLTSLDLSVNRI 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1147 SDDSLKILLQclpqlpqlsllqlrhtvlssrspfLLAdifnlcprvRKVTLRSLCHAvlhfdsneeqegvccgfpGCSLS 1226
Cdd:COG5238 305 GDEGAIALAE------------------------GLQ---------GNKTLHTLNLA------------------YNGIG 333
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 254692966 1227 QEHMETLCCALSKCNALSQLDLTDNLLGDIGLRCLLECLPQLPISGWLDLSHNNISQEGILYLLETL 1293
Cdd:COG5238 334 AQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDAL 400
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1766-1865 |
4.05e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 40.92 E-value: 4.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1766 LEQCPHIEEVSLAENNLAGGVP-RFSKR-----LPLLRQIDLEFCKIEDqaarhlAANLTLFPALEKLLLSGNLLGDevA 1839
Cdd:cd21340 86 LENLTNLEELHIENQRLPPGEKlTFDPRslaalSNSLRVLNISGNNIDS------LEPLAPLRNLEQLDASNNQISD--L 157
|
90 100
....*....|....*....|....*.
gi 254692966 1840 AELAQVLPQMGQLKKVNLEWNRITAR 1865
Cdd:cd21340 158 EELLDLLSSWPSLRELDLTGNPVCKK 183
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
710-787 |
4.39e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 40.54 E-value: 4.39e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254692966 710 CRSLPTMG-SLKTLGLTGSRITAqgishlIQTLPLCSQLEEVSLHDNQLKDPEVLSlvELLPSLPKLQKLDLSRNSFSR 787
Cdd:cd21340 112 PRSLAALSnSLRVLNISGNNIDS------LEPLAPLRNLEQLDASNNQISDLEELL--DLLSSWPSLRELDLTGNPVCK 182
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|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
746-789 |
4.95e-03 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 36.45 E-value: 4.95e-03
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 254692966 746 QLEEVSLHDNQLKDpevlslVELLPSLPKLQKLDLSRNSFSRSI 789
Cdd:pfam12799 2 NLEVLDLSNNQITD------IPPLAKLPNLETLDLSGNNKITDL 39
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
1630-1901 |
8.02e-03 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 41.37 E-value: 8.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1630 KLPELRKFNLSHNQIGhvgTQCLAAILPKLPELRKFDLSRNQigdvgtqcLAAILPK--LPELRKFDLSGNRIGPaggvQ 1707
Cdd:PLN00113 91 RLPYIQTINLSNNQLS---GPIPDDIFTTSSSLRYLNLSNNN--------FTGSIPRgsIPNLETLDLSNNMLSG----E 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1708 LVKSLTHFEHLEEIKLGNNALGEPTALELAQRlpPQLRVLCLPSSHLgpegALGLAQALEQCPHIEEVSLAENNLAGGVP 1787
Cdd:PLN00113 156 IPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNL--TSLEFLTLASNQL----VGQIPRELGQMKSLKWIYLGYNNLSGEIP 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692966 1788 RFSKRLPLLRQIDLEFCKIEDQAARHLaANLT----LFPALEKL-------------LLSGNLLGDEVAAELAQVLPQMG 1850
Cdd:PLN00113 230 YEIGGLTSLNHLDLVYNNLTGPIPSSL-GNLKnlqyLFLYQNKLsgpippsifslqkLISLDLSDNSLSGEIPELVIQLQ 308
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 254692966 1851 QLKKVNLEWNRITARgaqlLAQGLVQGSCVPVIRLWNNPILNDVAQSLQSQ 1901
Cdd:PLN00113 309 NLEILHLFSNNFTGK----IPVALTSLPRLQVLQLWSNKFSGEIPKNLGKH 355
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