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Conserved domains on  [gi|2027535357|ref|NP_001026997|]
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bolA-like protein 2 isoform 1 [Homo sapiens]

Protein Classification

BolA family protein( domain architecture ID 10484200)

BolA family protein may be a stress-responsive transcriptional regulator and may also participate in iron metabolism; similar to mammalian BolA-like proteins that act as iron-sulfur (Fe-S) cluster assembly factors that facilitate [2Fe-2S] cluster insertion into a subset of cytosolic proteins, and to Arabidopsis thaliana BOLA proteins that function as redox-regulated transcriptional regulators

CATH:  3.30.300.90
Gene Ontology:  GO:0051536|GO:0097428
SCOP:  4003220

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BolA pfam01722
BolA-like protein; This family consist of the morphoprotein BolA from E. coli and its various ...
 12-79 1.73e-22

BolA-like protein; This family consist of the morphoprotein BolA from E. coli and its various homologs. In E. coli over expression of this protein causes round morphology and may be involved in switching the cell between elongation and septation systems during cell division. The expression of BolA is growth rate regulated and is induced during the transition into the the stationary phase. BolA is also induced by stress during early stages of growth and may have a general role in stress response. It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5.


:

Pssm-ID: 460305  Cd Length: 75  Bit Score: 82.12  E-value: 1.73e-22
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2027535357 12 LQRDLEAEHVEVEDTTLN------RCSCSFRVLVVSAKFEGKPLLQRHRLVNACLAEELPH-IHAFEQKTLTPDQ 79
Cdd:pfam01722  1 LTEALAPTHLEVEDESHKhaghagGGETHFKVVIVSDAFEGKSLVARHRLVYDALADELAGgIHALSIKTYTPEE 75
 
Name Accession Description Interval E-value
BolA pfam01722
BolA-like protein; This family consist of the morphoprotein BolA from E. coli and its various ...
 12-79 1.73e-22

BolA-like protein; This family consist of the morphoprotein BolA from E. coli and its various homologs. In E. coli over expression of this protein causes round morphology and may be involved in switching the cell between elongation and septation systems during cell division. The expression of BolA is growth rate regulated and is induced during the transition into the the stationary phase. BolA is also induced by stress during early stages of growth and may have a general role in stress response. It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5.


Pssm-ID: 460305  Cd Length: 75  Bit Score: 82.12  E-value: 1.73e-22
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2027535357 12 LQRDLEAEHVEVEDTTLN------RCSCSFRVLVVSAKFEGKPLLQRHRLVNACLAEELPH-IHAFEQKTLTPDQ 79
Cdd:pfam01722  1 LTEALAPTHLEVEDESHKhaghagGGETHFKVVIVSDAFEGKSLVARHRLVYDALADELAGgIHALSIKTYTPEE 75
BolA COG0271
DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and ...
 5-82 1.29e-20

DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and biofilm formation [Transcription, Signal transduction mechanisms];


Pssm-ID: 440041  Cd Length: 90  Bit Score: 77.92  E-value: 1.29e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027535357  5 AEYLREKLQRDLEAEHVEVEDTT------LNRCSCS-FRVLVVSAKFEGKPLLQRHRLVNACLAEELPH-IHAFEQKTLT 76
Cdd:COG0271    4 QERIEEKLTAALAPEHLEVIDEShlhaghAGAGGEShFKVVIVSDAFAGKSRVARHRLVYAALADELAGgIHALAIHAYT 83


                 ....*.
gi 2027535357 77 PDQWAR 82
Cdd:COG0271   84 PEEWQA 89
PRK11628 PRK11628
transcriptional regulator BolA; Provisional
 6-81 4.74e-09

transcriptional regulator BolA; Provisional


Pssm-ID: 183243  Cd Length: 105  Bit Score: 48.62  E-value: 4.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027535357   6 EYLREKLQRDLEAEHVEVEDTTLNR-----CSCSFRVLVVSAKFEGKPLLQRHRLVNACLAEELPH-IHAFEQKTLTPDQ 79
Cdd:PRK11628    5 EQIEEKLRAAFQPVFLEVVDESYRHnvpagSESHFKVVLVSDRFTGERFLNRHRMIYSTLAEELSTtVHALALHTYTIKE 84


                  ..
gi 2027535357  80 WA 81
Cdd:PRK11628   85 WE 86
 
Name Accession Description Interval E-value
BolA pfam01722
BolA-like protein; This family consist of the morphoprotein BolA from E. coli and its various ...
 12-79 1.73e-22

BolA-like protein; This family consist of the morphoprotein BolA from E. coli and its various homologs. In E. coli over expression of this protein causes round morphology and may be involved in switching the cell between elongation and septation systems during cell division. The expression of BolA is growth rate regulated and is induced during the transition into the the stationary phase. BolA is also induced by stress during early stages of growth and may have a general role in stress response. It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5.


Pssm-ID: 460305  Cd Length: 75  Bit Score: 82.12  E-value: 1.73e-22
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2027535357 12 LQRDLEAEHVEVEDTTLN------RCSCSFRVLVVSAKFEGKPLLQRHRLVNACLAEELPH-IHAFEQKTLTPDQ 79
Cdd:pfam01722  1 LTEALAPTHLEVEDESHKhaghagGGETHFKVVIVSDAFEGKSLVARHRLVYDALADELAGgIHALSIKTYTPEE 75
BolA COG0271
DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and ...
 5-82 1.29e-20

DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and biofilm formation [Transcription, Signal transduction mechanisms];


Pssm-ID: 440041  Cd Length: 90  Bit Score: 77.92  E-value: 1.29e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027535357  5 AEYLREKLQRDLEAEHVEVEDTT------LNRCSCS-FRVLVVSAKFEGKPLLQRHRLVNACLAEELPH-IHAFEQKTLT 76
Cdd:COG0271    4 QERIEEKLTAALAPEHLEVIDEShlhaghAGAGGEShFKVVIVSDAFAGKSRVARHRLVYAALADELAGgIHALAIHAYT 83


                 ....*.
gi 2027535357 77 PDQWAR 82
Cdd:COG0271   84 PEEWQA 89
IbaG COG5007
Acid stress protein IbaG/YrbA, BolA-like family [Signal transduction mechanisms];
3-86 1.72e-18

Acid stress protein IbaG/YrbA, BolA-like family [Signal transduction mechanisms];


Pssm-ID: 444031  Cd Length: 81  Bit Score: 72.10  E-value: 1.72e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027535357  3 LSAEYLREKLQRDLEAEHVEVEDTtlnrcSCSFRVLVVSAKFEGKPLLQRHRLVNACLAEELP--HIHAFEQKTLTPDQW 80
Cdd:COG5007    1 MTPEEIKQLIEAGLPCAEVEVEGD-----GSHFEAIVVSDAFEGLSRVKRQQLVYAPLGDYIAsgEIHALSIKTYTPEEW 75


                 ....*.
gi 2027535357 81 ARERQK 86
Cdd:COG5007   76 AAQRKL 81
PRK11628 PRK11628
transcriptional regulator BolA; Provisional
 6-81 4.74e-09

transcriptional regulator BolA; Provisional


Pssm-ID: 183243  Cd Length: 105  Bit Score: 48.62  E-value: 4.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027535357   6 EYLREKLQRDLEAEHVEVEDTTLNR-----CSCSFRVLVVSAKFEGKPLLQRHRLVNACLAEELPH-IHAFEQKTLTPDQ 79
Cdd:PRK11628    5 EQIEEKLRAAFQPVFLEVVDESYRHnvpagSESHFKVVLVSDRFTGERFLNRHRMIYSTLAEELSTtVHALALHTYTIKE 84


                  ..
gi 2027535357  80 WA 81
Cdd:PRK11628   85 WE 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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