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Conserved domains on  [gi|164698546|ref|NP_001026919|]
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ly6/PLAUR domain-containing protein 5 isoform A precursor [Homo sapiens]

Protein Classification

LU domain-containing protein( domain architecture ID 10439911)

LU domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_LYPD5_rpt1 cd23565
first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 5 (LYPD5) and ...
 22-116 5.64e-57

first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 5 (LYPD5) and similar proteins; LYPD5 (also called Haldisin (human antigen with LU-domains expressed in skin)) is a novel differentiation marker of stratum granulosum in squamous epithelia. LYPD5 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


:

Pssm-ID: 467095  Cd Length: 95  Bit Score: 176.59  E-value: 5.64e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698546  22 GSQALQCYSFEHTYFGPFDLRAMKLPSISCPHECFEAILSLDTGYRAPVTLVRKGCWTGPPAGQTQSNADALPPDYSVVR 101
Cdd:cd23565    1 GSQALQCYSFEHTYFGPFDLSALKLPSVSCPQGCFEAVLSLSTGYRSPVTLVRKGCWTGPGTGQMQSNSDALPPDYSVVR 80

                         90
                 ....*....|....*
gi 164698546 102 GCTTDKCNAHLMTHD 116
Cdd:cd23565   81 GCATDLCNADLLTHD 95
TFP_LU_ECD_LYPD5_rpt2 cd23566
second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 5 (LYPD5) and ...
 125-217 2.97e-42

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 5 (LYPD5) and similar proteins; LYPD5 (also called Haldisin (human antigen with LU-domains expressed in skin)) is a novel differentiation marker of stratum granulosum in squamous epithelia. LYPD5 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


:

Pssm-ID: 467096  Cd Length: 96  Bit Score: 139.08  E-value: 2.97e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698546 125 PDPPTLSGAECYACIGVHQDDCAIGRSRRVQCHQDQTACFQGNGRMTVG--NFSVPVYIRTCHRPSCTTEGTTSPWTA-I 201
Cdd:cd23566    1 PDPPTPNGMECYACLSFSPDDCSPENAEKVKCHGDMTRCYEGNGTVTIGndNFSVPIYIKTCQAPSCTTPGSTSPWTAiI 80

                         90
                 ....*....|....*.
gi 164698546 202 DLQGSCCEGYLCNRKS 217
Cdd:cd23566   81 SQQGSCCSGSLCNGPS 96
 
Name Accession Description Interval E-value
TFP_LU_ECD_LYPD5_rpt1 cd23565
first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 5 (LYPD5) and ...
 22-116 5.64e-57

first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 5 (LYPD5) and similar proteins; LYPD5 (also called Haldisin (human antigen with LU-domains expressed in skin)) is a novel differentiation marker of stratum granulosum in squamous epithelia. LYPD5 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467095  Cd Length: 95  Bit Score: 176.59  E-value: 5.64e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698546  22 GSQALQCYSFEHTYFGPFDLRAMKLPSISCPHECFEAILSLDTGYRAPVTLVRKGCWTGPPAGQTQSNADALPPDYSVVR 101
Cdd:cd23565    1 GSQALQCYSFEHTYFGPFDLSALKLPSVSCPQGCFEAVLSLSTGYRSPVTLVRKGCWTGPGTGQMQSNSDALPPDYSVVR 80

                         90
                 ....*....|....*
gi 164698546 102 GCTTDKCNAHLMTHD 116
Cdd:cd23565   81 GCATDLCNADLLTHD 95
TFP_LU_ECD_LYPD5_rpt2 cd23566
second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 5 (LYPD5) and ...
 125-217 2.97e-42

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 5 (LYPD5) and similar proteins; LYPD5 (also called Haldisin (human antigen with LU-domains expressed in skin)) is a novel differentiation marker of stratum granulosum in squamous epithelia. LYPD5 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467096  Cd Length: 96  Bit Score: 139.08  E-value: 2.97e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698546 125 PDPPTLSGAECYACIGVHQDDCAIGRSRRVQCHQDQTACFQGNGRMTVG--NFSVPVYIRTCHRPSCTTEGTTSPWTA-I 201
Cdd:cd23566    1 PDPPTPNGMECYACLSFSPDDCSPENAEKVKCHGDMTRCYEGNGTVTIGndNFSVPIYIKTCQAPSCTTPGSTSPWTAiI 80

                         90
                 ....*....|....*.
gi 164698546 202 DLQGSCCEGYLCNRKS 217
Cdd:cd23566   81 SQQGSCCSGSLCNGPS 96
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 135-214 2.35e-15

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 68.72  E-value: 2.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698546  135 CYACIGVHQDDCaigrSRRVQCHQDQTACFQGNGRMTVGNFSVPVYIRTCHRPSCT-TEGTTSPWTAIDLQGSCCEGYLC 213
Cdd:pfam00021   1 CYSCLGVSNEDC----LSEVTCPLSDGQCVTTTLELPEGNLRGTVVSKGCARSSCPrLLSDFINGGIISVSESCCQSDLC 76


                  .
gi 164698546  214 N 214
Cdd:pfam00021  77 N 77
 
Name Accession Description Interval E-value
TFP_LU_ECD_LYPD5_rpt1 cd23565
first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 5 (LYPD5) and ...
 22-116 5.64e-57

first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 5 (LYPD5) and similar proteins; LYPD5 (also called Haldisin (human antigen with LU-domains expressed in skin)) is a novel differentiation marker of stratum granulosum in squamous epithelia. LYPD5 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467095  Cd Length: 95  Bit Score: 176.59  E-value: 5.64e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698546  22 GSQALQCYSFEHTYFGPFDLRAMKLPSISCPHECFEAILSLDTGYRAPVTLVRKGCWTGPPAGQTQSNADALPPDYSVVR 101
Cdd:cd23565    1 GSQALQCYSFEHTYFGPFDLSALKLPSVSCPQGCFEAVLSLSTGYRSPVTLVRKGCWTGPGTGQMQSNSDALPPDYSVVR 80

                         90
                 ....*....|....*
gi 164698546 102 GCTTDKCNAHLMTHD 116
Cdd:cd23565   81 GCATDLCNADLLTHD 95
TFP_LU_ECD_LYPD5_rpt2 cd23566
second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 5 (LYPD5) and ...
 125-217 2.97e-42

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 5 (LYPD5) and similar proteins; LYPD5 (also called Haldisin (human antigen with LU-domains expressed in skin)) is a novel differentiation marker of stratum granulosum in squamous epithelia. LYPD5 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467096  Cd Length: 96  Bit Score: 139.08  E-value: 2.97e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698546 125 PDPPTLSGAECYACIGVHQDDCAIGRSRRVQCHQDQTACFQGNGRMTVG--NFSVPVYIRTCHRPSCTTEGTTSPWTA-I 201
Cdd:cd23566    1 PDPPTPNGMECYACLSFSPDDCSPENAEKVKCHGDMTRCYEGNGTVTIGndNFSVPIYIKTCQAPSCTTPGSTSPWTAiI 80

                         90
                 ....*....|....*.
gi 164698546 202 DLQGSCCEGYLCNRKS 217
Cdd:cd23566   81 SQQGSCCSGSLCNGPS 96
TFP_LU_ECD_LYPD3_rpt2 cd23563
second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and ...
 131-215 6.72e-17

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and similar proteins; LYPD3 (also called GPI-anchored metastasis-associated protein C4.4A homolog, or matrigel-induced gene C4 protein (MIG-C4)) supports cell migration. It may be involved in urothelial cell-matrix interactions as well as in tumor progression. LYPD3 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467093  Cd Length: 88  Bit Score: 73.26  E-value: 6.72e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698546 131 SGAECYACIGVHQDDCAIGRSRRVQCHQDQTACFQGNGRMTVGNFSVPVYIRTC-HRPSCTTEGTTSPwtAIDLQGSCCE 209
Cdd:cd23563    2 NGVECYSCVGNSRGACSPSNAPVVRCYGAYSGCFDGNVTLTIGNVTLSLPVKGCvQDGDCTRESKGGA--SVTLKGSCCS 79


                 ....*.
gi 164698546 210 GYLCNR 215
Cdd:cd23563   80 GNLCNS 85
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 135-214 2.35e-15

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 68.72  E-value: 2.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698546  135 CYACIGVHQDDCaigrSRRVQCHQDQTACFQGNGRMTVGNFSVPVYIRTCHRPSCT-TEGTTSPWTAIDLQGSCCEGYLC 213
Cdd:pfam00021   1 CYSCLGVSNEDC----LSEVTCPLSDGQCVTTTLELPEGNLRGTVVSKGCARSSCPrLLSDFINGGIISVSESCCQSDLC 76


                  .
gi 164698546  214 N 214
Cdd:pfam00021  77 N 77
TFP_LU_ECD_uPAR_rpt3 cd23558
third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 129-214 2.03e-05

third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


Pssm-ID: 467088  Cd Length: 93  Bit Score: 42.00  E-value: 2.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698546 129 TLSGAECYACIGVHQDDCAIGRSRRVQCHQDQTACFQGNGRMTVGNFSVPVYIRTCHRPS-CTTEGTTSPWTAIDLQGSC 207
Cdd:cd23558    4 PPNGIQCYSCNGNSTHGCSSEETSKVRCRGPQTQCLEATGTTAHGGKNQSYMVKGCATPSmCQSTALSLNQVLNSADVRC 83


                 ....*..
gi 164698546 208 CEGYLCN 214
Cdd:cd23558   84 CNGSLCN 90
TFP cd00117
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 134-214 1.83e-03

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


Pssm-ID: 467060  Cd Length: 81  Bit Score: 36.31  E-value: 1.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698546 134 ECYACIGVHQDDCAIGRSRRVQCHQDQTACFQGNGRMTVGNfsvPVYIRTC--HRPSCTTEGTTSPWTAIDLQGSCCEGY 211
Cdd:cd00117    2 KCYQCNSSNDPNCCNSSPTLVTCSSPETFCRKIVGKVGGGE---TLVIRGCatECECGCTECCSGTGTSGTTCTSCCDTD 78


                 ...
gi 164698546 212 LCN 214
Cdd:cd00117   79 LCN 81
TFP_LU_ECD_LYPD3_rpt1 cd23562
first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and ...
 134-216 1.96e-03

first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and similar proteins; LYPD3 (also called GPI-anchored metastasis-associated protein C4.4A homolog, or matrigel-induced gene C4 protein (MIG-C4)) supports cell migration. It may be involved in urothelial cell-matrix interactions as well as in tumor progression. LYPD3 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467092  Cd Length: 87  Bit Score: 36.56  E-value: 1.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698546 134 ECYACIGVHQDDCAIGRSRRVQCHQDQTACFQGNGRMTVGNFSVPVYIRTC--HRPSCTTEGTTSPWTAIDLQGSCCEGY 211
Cdd:cd23562    2 ECYSCVEEGDGGCSPAKMTTVSCAPPMNVCTEYVAAVKTSHGTLTLRKKGCgsGLPGKLDRGLTLHGLYAFIQLRACNTS 81


                 ....*
gi 164698546 212 LCNRK 216
Cdd:cd23562   82 LCNNE 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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