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Conserved domains on  [gi|237681194|ref|NP_001019784|]
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fez family zinc finger protein 1 isoform 1 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 13416207)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|30718982
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
305-327 2.75e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.75e-04
                          10        20
                  ....*....|....*....|...
gi 237681194  305 RHKIIHTQEKPHKCNQCGKAFNR 327
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 368-424 7.15e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 7.15e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 237681194 368 GEKQFKCNI--CNKAFHQVYNLTFHM-HTHNDK------------------KPFTCPTCGKGFCRNFDLKKHVRKLHD 424
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHMlHGHQNQklhenpspekmnifsakdKPYRCEVCDKRYKNLNGLKYHRKHSHD 423
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
171-379 5.16e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 5.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237681194 171 HPAAGVNIHPVASYFLSSPLHPQPKTYLAERNKLVVPAVEKYPSGV--AFKDLSQAQLQHYMKESAQLLSEKIAFKTSDF 248
Cdd:COG5048  231 TNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNesDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLR 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237681194 249 SR--GSPNAKPKVFTCEVCGKVFNAHYNLTRHMPVHTGARPFVCK--VCGKGFRQASTLCRHKIIHTQEKPHK------- 317
Cdd:COG5048  311 SVnhSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKDLKNdkksetl 390

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 237681194 318 CNQCGKAFNRSSTLNTHTRIHAGYKPFVCEF--CGKGFHQKGNYKNHKLTHSGEKQFKCNICNK 379
Cdd:COG5048  391 SNSCIRNFKRDSNLSLHIITHLSFRPYNCKNppCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
305-327 2.75e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.75e-04
                          10        20
                  ....*....|....*....|...
gi 237681194  305 RHKIIHTQEKPHKCNQCGKAFNR 327
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 368-424 7.15e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 7.15e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 237681194 368 GEKQFKCNI--CNKAFHQVYNLTFHM-HTHNDK------------------KPFTCPTCGKGFCRNFDLKKHVRKLHD 424
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHMlHGHQNQklhenpspekmnifsakdKPYRCEVCDKRYKNLNGLKYHRKHSHD 423
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
171-379 5.16e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 5.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237681194 171 HPAAGVNIHPVASYFLSSPLHPQPKTYLAERNKLVVPAVEKYPSGV--AFKDLSQAQLQHYMKESAQLLSEKIAFKTSDF 248
Cdd:COG5048  231 TNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNesDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLR 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237681194 249 SR--GSPNAKPKVFTCEVCGKVFNAHYNLTRHMPVHTGARPFVCK--VCGKGFRQASTLCRHKIIHTQEKPHK------- 317
Cdd:COG5048  311 SVnhSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKDLKNdkksetl 390

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 237681194 318 CNQCGKAFNRSSTLNTHTRIHAGYKPFVCEF--CGKGFHQKGNYKNHKLTHSGEKQFKCNICNK 379
Cdd:COG5048  391 SNSCIRNFKRDSNLSLHIITHLSFRPYNCKNppCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
305-327 2.75e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.75e-04
                          10        20
                  ....*....|....*....|...
gi 237681194  305 RHKIIHTQEKPHKCNQCGKAFNR 327
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 368-424 7.15e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 7.15e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 237681194 368 GEKQFKCNI--CNKAFHQVYNLTFHM-HTHNDK------------------KPFTCPTCGKGFCRNFDLKKHVRKLHD 424
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHMlHGHQNQklhenpspekmnifsakdKPYRCEVCDKRYKNLNGLKYHRKHSHD 423
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 316-338 3.77e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 3.77e-03
                          10        20
                  ....*....|....*....|...
gi 237681194  316 HKCNQCGKAFNRSSTLNTHTRIH 338
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
171-379 5.16e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 5.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237681194 171 HPAAGVNIHPVASYFLSSPLHPQPKTYLAERNKLVVPAVEKYPSGV--AFKDLSQAQLQHYMKESAQLLSEKIAFKTSDF 248
Cdd:COG5048  231 TNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNesDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLR 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237681194 249 SR--GSPNAKPKVFTCEVCGKVFNAHYNLTRHMPVHTGARPFVCK--VCGKGFRQASTLCRHKIIHTQEKPHK------- 317
Cdd:COG5048  311 SVnhSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKDLKNdkksetl 390

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 237681194 318 CNQCGKAFNRSSTLNTHTRIHAGYKPFVCEF--CGKGFHQKGNYKNHKLTHSGEKQFKCNICNK 379
Cdd:COG5048  391 SNSCIRNFKRDSNLSLHIITHLSFRPYNCKNppCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
312-409 8.25e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.52  E-value: 8.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237681194 312 QEKPHKCNQCGKAFNRSSTLNTHTRIHAGYKPFVCEFCGKGFHQKGNYKNHKL---THSGEKQFKCNICNKAFHQVYNLT 388
Cdd:COG5048   30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHlrtHHNNPSDLNSKSLPLSNSKASSSS 109

                         90       100
                 ....*....|....*....|.
gi 237681194 389 FHMHTHNDKKPFTCPTCGKGF 409
Cdd:COG5048  110 LSSSSSNSNDNNLLSSHSLPP 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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