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Conserved domains on  [gi|66392203|ref|NP_001018146|]
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NME1-NME2 protein [Homo sapiens]

Protein Classification

NME1-NME2 protein( domain architecture ID 10858359)

NME1-NME2 protein may act as nucleoside diphosphate kinase that has additional roles in signal transduction, transcription, and apoptosis

CATH:  3.30.70.141
EC:  2.7.4.6|2.7.13.3
Gene Ontology:  GO:0006165|GO:0006241|GO:0004550|GO:0046872|GO:0005524|GO:0006228|GO:0006183
SCOP:  4001261

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PTZ00093 PTZ00093
nucleoside diphosphate kinase, cytosolic; Provisional
 118-266 1.70e-96

nucleoside diphosphate kinase, cytosolic; Provisional


:

Pssm-ID: 173387  Cd Length: 149  Bit Score: 279.69  E-value: 1.70e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203  118 NLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLN 197
Cdd:PTZ00093   1 SSERTFIMVKPDGVQRGLVGEIIKRFEKKGYKLVALKMLQPTPEIAEEHYKEHKGKPFFPGLVKYISSGPVVCMVWEGKN 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 66392203  198 VVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELVDYKSCAHDWVY 266
Cdd:PTZ00093  81 VVKQGRKLLGATNPLESAPGTIRGDFCVDVGRNVIHGSDSVESAKREIALWFKPEELVSWTSHSSKWIY 149
NDPk_I cd04413
Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large ...
 5-114 3.01e-73

Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside triphosphate (NTP) donor onto a nucleoside diphosphate (NDP) acceptor through a phosphohistidine intermediate. The mammalian nm23/NDP kinase gene family can be divided into two distinct groups. The group I genes encode proteins that generally have highly homologous counterparts in other organisms and possess the classic enzymatic activity of a kinase. This group includes vertebrate NDP kinases A-D (Nm23- H1 to -H4), and its counterparts in bacteria, archea and other eukaryotes. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. They possess the NDP kinase active site motif (NXXH[G/A]SD) and the nine residues that are most essential for catalysis.


:

Pssm-ID: 239876  Cd Length: 130  Bit Score: 219.65  E-value: 3.01e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203   5 ERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVV 84
Cdd:cd04413   1 ERTLVIIKPDGVQRGLIGEIISRFERKGLKIVALKMLQLTEELAEEHYAEHKGKPFFPELVEFMTSGPVVAMVLEGENAV 80

                        90       100       110
                ....*....|....*....|....*....|
gi 66392203  85 KTGRVMLGETNPADSKPGTIRGDFCIQVGR 114
Cdd:cd04413  81 KTVRKLMGATNPADAAPGTIRGDFALSIGR 110
 
Name Accession Description Interval E-value
PTZ00093 PTZ00093
nucleoside diphosphate kinase, cytosolic; Provisional
 118-266 1.70e-96

nucleoside diphosphate kinase, cytosolic; Provisional


Pssm-ID: 173387  Cd Length: 149  Bit Score: 279.69  E-value: 1.70e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203  118 NLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLN 197
Cdd:PTZ00093   1 SSERTFIMVKPDGVQRGLVGEIIKRFEKKGYKLVALKMLQPTPEIAEEHYKEHKGKPFFPGLVKYISSGPVVCMVWEGKN 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 66392203  198 VVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELVDYKSCAHDWVY 266
Cdd:PTZ00093  81 VVKQGRKLLGATNPLESAPGTIRGDFCVDVGRNVIHGSDSVESAKREIALWFKPEELVSWTSHSSKWIY 149
NDPk_I cd04413
Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large ...
 120-249 8.00e-92

Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside triphosphate (NTP) donor onto a nucleoside diphosphate (NDP) acceptor through a phosphohistidine intermediate. The mammalian nm23/NDP kinase gene family can be divided into two distinct groups. The group I genes encode proteins that generally have highly homologous counterparts in other organisms and possess the classic enzymatic activity of a kinase. This group includes vertebrate NDP kinases A-D (Nm23- H1 to -H4), and its counterparts in bacteria, archea and other eukaryotes. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. They possess the NDP kinase active site motif (NXXH[G/A]SD) and the nine residues that are most essential for catalysis.


Pssm-ID: 239876  Cd Length: 130  Bit Score: 267.03  E-value: 8.00e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203 120 ERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVV 199
Cdd:cd04413   1 ERTLVIIKPDGVQRGLIGEIISRFERKGLKIVALKMLQLTEELAEEHYAEHKGKPFFPELVEFMTSGPVVAMVLEGENAV 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 66392203 200 KTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWF 249
Cdd:cd04413  81 KTVRKLMGATNPADAAPGTIRGDFALSIGRNIVHGSDSVESAEREIALWF 130
NDK pfam00334
Nucleoside diphosphate kinase;
120-254 6.17e-86

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 252.02  E-value: 6.17e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203   120 ERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVV 199
Cdd:pfam00334   1 ERTLAIIKPDAVQRGLIGEIISRFERKGFKIVALKMLQLTREQAEEHYAEHKGKPFFPDLVEFMTSGPVVAMVLEGENAI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 66392203   200 KTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEEL 254
Cdd:pfam00334  81 SKWRELMGATNPAEAAPGTIRGDFAVSIGRNAVHGSDSPESAEREIALFFPEEEI 135
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 120-257 2.49e-84

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 248.44  E-value: 2.49e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203 120 ERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVV 199
Cdd:COG0105   3 ERTLVIIKPDAVQRGLIGEIISRFERKGLKIVALKMLQLTREQAEEHYAEHKGKPFFGELVEFMTSGPVVAMVLEGENAV 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 66392203 200 KTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELVDY 257
Cdd:COG0105  83 AVVRKLMGATNPAEAAPGTIRGDFALSIGENAVHGSDSPESAEREIALFFSEEEIVSY 140
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 120-254 8.98e-82

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 241.69  E-value: 8.98e-82
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203    120 ERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVV 199
Cdd:smart00562   1 ERTLAIIKPDAVQRGLIGEIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEGKPFFNDLVEFMTSGPVVAMVLEGEDAV 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 66392203    200 KTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEEL 254
Cdd:smart00562  81 KTWRTLMGPTDPREAAPGTIRGDFGLDIGRNAVHGSDSPESAEREIALFFPESEI 135
NDPk_I cd04413
Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large ...
 5-114 3.01e-73

Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside triphosphate (NTP) donor onto a nucleoside diphosphate (NDP) acceptor through a phosphohistidine intermediate. The mammalian nm23/NDP kinase gene family can be divided into two distinct groups. The group I genes encode proteins that generally have highly homologous counterparts in other organisms and possess the classic enzymatic activity of a kinase. This group includes vertebrate NDP kinases A-D (Nm23- H1 to -H4), and its counterparts in bacteria, archea and other eukaryotes. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. They possess the NDP kinase active site motif (NXXH[G/A]SD) and the nine residues that are most essential for catalysis.


Pssm-ID: 239876  Cd Length: 130  Bit Score: 219.65  E-value: 3.01e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203   5 ERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVV 84
Cdd:cd04413   1 ERTLVIIKPDGVQRGLIGEIISRFERKGLKIVALKMLQLTEELAEEHYAEHKGKPFFPELVEFMTSGPVVAMVLEGENAV 80

                        90       100       110
                ....*....|....*....|....*....|
gi 66392203  85 KTGRVMLGETNPADSKPGTIRGDFCIQVGR 114
Cdd:cd04413  81 KTVRKLMGATNPADAAPGTIRGDFALSIGR 110
ndk PRK00668
mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
 5-114 5.45e-63

mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated


Pssm-ID: 179085  Cd Length: 134  Bit Score: 193.78  E-value: 5.45e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203    5 ERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVV 84
Cdd:PRK00668   2 ERTFSIIKPDAVQRGLIGEIISRFEKKGLKIVALKMMQLSRELAEGHYAEHKEKPFFGELVEFMTSGPVVVMVLEGENAI 81

                         90       100       110
                 ....*....|....*....|....*....|
gi 66392203   85 KTGRVMLGETNPADSKPGTIRGDFCIQVGR 114
Cdd:PRK00668  82 AKVRELMGATNPAEAAPGTIRGDFALSIGE 111
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 5-114 4.99e-62

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 191.61  E-value: 4.99e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203      5 ERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVV 84
Cdd:smart00562   1 ERTLAIIKPDAVQRGLIGEIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEGKPFFNDLVEFMTSGPVVAMVLEGEDAV 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 66392203     85 KTGRVMLGETNPADSKPGTIRGDFCIQVGR 114
Cdd:smart00562  81 KTWRTLMGPTDPREAAPGTIRGDFGLDIGR 110
 
Name Accession Description Interval E-value
PTZ00093 PTZ00093
nucleoside diphosphate kinase, cytosolic; Provisional
 118-266 1.70e-96

nucleoside diphosphate kinase, cytosolic; Provisional


Pssm-ID: 173387  Cd Length: 149  Bit Score: 279.69  E-value: 1.70e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203  118 NLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLN 197
Cdd:PTZ00093   1 SSERTFIMVKPDGVQRGLVGEIIKRFEKKGYKLVALKMLQPTPEIAEEHYKEHKGKPFFPGLVKYISSGPVVCMVWEGKN 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 66392203  198 VVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELVDYKSCAHDWVY 266
Cdd:PTZ00093  81 VVKQGRKLLGATNPLESAPGTIRGDFCVDVGRNVIHGSDSVESAKREIALWFKPEELVSWTSHSSKWIY 149
NDPk_I cd04413
Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large ...
 120-249 8.00e-92

Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside triphosphate (NTP) donor onto a nucleoside diphosphate (NDP) acceptor through a phosphohistidine intermediate. The mammalian nm23/NDP kinase gene family can be divided into two distinct groups. The group I genes encode proteins that generally have highly homologous counterparts in other organisms and possess the classic enzymatic activity of a kinase. This group includes vertebrate NDP kinases A-D (Nm23- H1 to -H4), and its counterparts in bacteria, archea and other eukaryotes. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. They possess the NDP kinase active site motif (NXXH[G/A]SD) and the nine residues that are most essential for catalysis.


Pssm-ID: 239876  Cd Length: 130  Bit Score: 267.03  E-value: 8.00e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203 120 ERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVV 199
Cdd:cd04413   1 ERTLVIIKPDGVQRGLIGEIISRFERKGLKIVALKMLQLTEELAEEHYAEHKGKPFFPELVEFMTSGPVVAMVLEGENAV 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 66392203 200 KTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWF 249
Cdd:cd04413  81 KTVRKLMGATNPADAAPGTIRGDFALSIGRNIVHGSDSVESAEREIALWF 130
NDK pfam00334
Nucleoside diphosphate kinase;
120-254 6.17e-86

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 252.02  E-value: 6.17e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203   120 ERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVV 199
Cdd:pfam00334   1 ERTLAIIKPDAVQRGLIGEIISRFERKGFKIVALKMLQLTREQAEEHYAEHKGKPFFPDLVEFMTSGPVVAMVLEGENAI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 66392203   200 KTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEEL 254
Cdd:pfam00334  81 SKWRELMGATNPAEAAPGTIRGDFAVSIGRNAVHGSDSPESAEREIALFFPEEEI 135
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 120-257 2.49e-84

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 248.44  E-value: 2.49e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203 120 ERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVV 199
Cdd:COG0105   3 ERTLVIIKPDAVQRGLIGEIISRFERKGLKIVALKMLQLTREQAEEHYAEHKGKPFFGELVEFMTSGPVVAMVLEGENAV 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 66392203 200 KTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELVDY 257
Cdd:COG0105  83 AVVRKLMGATNPAEAAPGTIRGDFALSIGENAVHGSDSPESAEREIALFFSEEEIVSY 140
PLN02619 PLN02619
nucleoside-diphosphate kinase
 117-267 4.56e-82

nucleoside-diphosphate kinase


Pssm-ID: 178228  Cd Length: 238  Bit Score: 246.30  E-value: 4.56e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203  117 ANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGL 196
Cdd:PLN02619  86 AEMERTFIAIKPDGVQRGLISEIISRFERKGFKLVAIKVVVPSKEFAQKHYHDLKERPFFNGLCDFLSSGPVVAMVWEGE 165

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 66392203  197 NVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELVDYKSCAHDWVYE 267
Cdd:PLN02619 166 GVIKYGRKLIGATDPQKSEPGTIRGDLAVVVGRNIIHGSDGPETAKDEINLWFKPEELVSYTSNAEKWIYG 236
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 120-254 8.98e-82

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 241.69  E-value: 8.98e-82
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203    120 ERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVV 199
Cdd:smart00562   1 ERTLAIIKPDAVQRGLIGEIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEGKPFFNDLVEFMTSGPVVAMVLEGEDAV 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 66392203    200 KTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEEL 254
Cdd:smart00562  81 KTWRTLMGPTDPREAAPGTIRGDFGLDIGRNAVHGSDSPESAEREIALFFPESEI 135
ndk PRK00668
mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
 119-252 5.09e-81

mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated


Pssm-ID: 179085  Cd Length: 134  Bit Score: 239.62  E-value: 5.09e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203  119 LERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNV 198
Cdd:PRK00668   1 MERTFSIIKPDAVQRGLIGEIISRFEKKGLKIVALKMMQLSRELAEGHYAEHKEKPFFGELVEFMTSGPVVVMVLEGENA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 66392203  199 VKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPE 252
Cdd:PRK00668  81 IAKVRELMGATNPAEAAPGTIRGDFALSIGENVVHGSDSPESAAREIALFFSEE 134
NDPk_I cd04413
Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large ...
 5-114 3.01e-73

Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside triphosphate (NTP) donor onto a nucleoside diphosphate (NDP) acceptor through a phosphohistidine intermediate. The mammalian nm23/NDP kinase gene family can be divided into two distinct groups. The group I genes encode proteins that generally have highly homologous counterparts in other organisms and possess the classic enzymatic activity of a kinase. This group includes vertebrate NDP kinases A-D (Nm23- H1 to -H4), and its counterparts in bacteria, archea and other eukaryotes. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. They possess the NDP kinase active site motif (NXXH[G/A]SD) and the nine residues that are most essential for catalysis.


Pssm-ID: 239876  Cd Length: 130  Bit Score: 219.65  E-value: 3.01e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203   5 ERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVV 84
Cdd:cd04413   1 ERTLVIIKPDGVQRGLIGEIISRFERKGLKIVALKMLQLTEELAEEHYAEHKGKPFFPELVEFMTSGPVVAMVLEGENAV 80

                        90       100       110
                ....*....|....*....|....*....|
gi 66392203  85 KTGRVMLGETNPADSKPGTIRGDFCIQVGR 114
Cdd:cd04413  81 KTVRKLMGATNPADAAPGTIRGDFALSIGR 110
NDPk cd00595
Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the ...
 120-249 9.68e-71

Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are vital for DNA/RNA synthesis, cell division, macromolecular metabolism and growth. The enzymes generate NTPs or their deoxy derivatives by terminal (gamma) phosphotransfer from an NTP such as ATP or GTP to any nucleoside diphosphate (NDP) or its deoxy derivative. The sequence of NDPk has been highly conserved through evolution. There is a single histidine residue conserved in all known NDK isozymes, which is involved in the catalytic mechanism. The first confirmed metastasis suppressor gene was the NDP kinase protein encoded by the nm23 gene. Unicellular organisms generally possess only one gene encoding NDP kinase, while most multicellular organisms possess not only an ortholog that provides most of the NDP kinase enzymatic activity but also multiple divergent paralogous genes. The human genome codes for at least nine NDP kinases and can be classified into two groups, Groups I and II, according to their genomic architecture and distinct enzymatic activity. Group I isoforms (A-D) are well-conserved, catalytically active, and share 58-88% identity between each other, while Group II are more divergent, with only NDPk6 shown to be active. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. The hexamer can be viewed as trimer of dimers, while tetramers are dimers of dimers, with the dimerization interface conserved.


Pssm-ID: 238335  Cd Length: 133  Bit Score: 213.75  E-value: 9.68e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203 120 ERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVV 199
Cdd:cd00595   1 ERTLALIKPDAVAEGLLGEIIMRIEDAGFEIVAMKELHLTEEQAEEFYVEHKGRPFFPDLVQFMSSGPVVAMILEKDNAV 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 66392203 200 KTGRVMLGETNPA---DSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWF 249
Cdd:cd00595  81 GEWREMLGPTNPEiarHLAPGSLRADFGTDVLRNAVHGSDSVESAAREIAFFF 133
ndk PRK00668
mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
 5-114 5.45e-63

mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated


Pssm-ID: 179085  Cd Length: 134  Bit Score: 193.78  E-value: 5.45e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203    5 ERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVV 84
Cdd:PRK00668   2 ERTFSIIKPDAVQRGLIGEIISRFEKKGLKIVALKMMQLSRELAEGHYAEHKEKPFFGELVEFMTSGPVVVMVLEGENAI 81

                         90       100       110
                 ....*....|....*....|....*....|
gi 66392203   85 KTGRVMLGETNPADSKPGTIRGDFCIQVGR 114
Cdd:PRK00668  82 AKVRELMGATNPAEAAPGTIRGDFALSIGE 111
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 5-114 4.99e-62

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 191.61  E-value: 4.99e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203      5 ERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVV 84
Cdd:smart00562   1 ERTLAIIKPDAVQRGLIGEIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEGKPFFNDLVEFMTSGPVVAMVLEGEDAV 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 66392203     85 KTGRVMLGETNPADSKPGTIRGDFCIQVGR 114
Cdd:smart00562  81 KTWRTLMGPTDPREAAPGTIRGDFGLDIGR 110
NDPk cd00595
Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the ...
 5-114 1.22e-51

Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are vital for DNA/RNA synthesis, cell division, macromolecular metabolism and growth. The enzymes generate NTPs or their deoxy derivatives by terminal (gamma) phosphotransfer from an NTP such as ATP or GTP to any nucleoside diphosphate (NDP) or its deoxy derivative. The sequence of NDPk has been highly conserved through evolution. There is a single histidine residue conserved in all known NDK isozymes, which is involved in the catalytic mechanism. The first confirmed metastasis suppressor gene was the NDP kinase protein encoded by the nm23 gene. Unicellular organisms generally possess only one gene encoding NDP kinase, while most multicellular organisms possess not only an ortholog that provides most of the NDP kinase enzymatic activity but also multiple divergent paralogous genes. The human genome codes for at least nine NDP kinases and can be classified into two groups, Groups I and II, according to their genomic architecture and distinct enzymatic activity. Group I isoforms (A-D) are well-conserved, catalytically active, and share 58-88% identity between each other, while Group II are more divergent, with only NDPk6 shown to be active. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. The hexamer can be viewed as trimer of dimers, while tetramers are dimers of dimers, with the dimerization interface conserved.


Pssm-ID: 238335  Cd Length: 133  Bit Score: 164.83  E-value: 1.22e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203   5 ERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVV 84
Cdd:cd00595   1 ERTLALIKPDAVAEGLLGEIIMRIEDAGFEIVAMKELHLTEEQAEEFYVEHKGRPFFPDLVQFMSSGPVVAMILEKDNAV 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 66392203  85 KTGRVMLGETNPA---DSKPGTIRGDFCIQVGR 114
Cdd:cd00595  81 GEWREMLGPTNPEiarHLAPGSLRADFGTDVLR 113
PRK14540 PRK14540
nucleoside diphosphate kinase; Provisional
 119-250 1.75e-50

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184733  Cd Length: 134  Bit Score: 162.30  E-value: 1.75e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203  119 LERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNV 198
Cdd:PRK14540   2 KERTFVALKPDAVERKLIGKIIQRFENKGFEIVEMKMLKLTREMAEEYYEEHKGKEFYERLINFMTSGRIVAMVIEGENA 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 66392203  199 VKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFK 250
Cdd:PRK14540  82 ISTVRKMIGKTNPAEAEPGTIRGDFGLYTPANIIHASDSKESAEREIKLFFG 133
PRK14544 PRK14544
nucleoside diphosphate kinase; Provisional
 119-256 4.03e-42

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173010 [Multi-domain]  Cd Length: 183  Bit Score: 142.26  E-value: 4.03e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203  119 LERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHY----------------------IDLK----- 171
Cdd:PRK14544   3 IERTLVILKPDAVKRGLVGEIISRFEKAGLKIVAMKMVKATPEQIERFYpsseewyrsvgnkllkayqelgIDPRarlgt 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203  172 DRPFFPG------LVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCI----------QVGRNIIHGS 235
Cdd:PRK14544  83 DDPVEVGkkvkesLVKYMTSGPIVAMVLKGNRAVEVVRKLVGPTSPHKAPPGTIRGDYSIdspdlaaeegRVVYNLVHAS 162

                        170       180
                 ....*....|....*....|.
gi 66392203  236 DSVKSAEKEISLWFKPEELVD 256
Cdd:PRK14544 163 DSPEEAEREIKFWFREEEILD 183
PRK14542 PRK14542
nucleoside diphosphate kinase; Provisional
 119-254 1.11e-37

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173008 [Multi-domain]  Cd Length: 137  Bit Score: 129.40  E-value: 1.11e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203  119 LERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNV 198
Cdd:PRK14542   1 MSRTFIMIKPDGVKNKHVGNILQRIEKEGFKILGLKYLKLSLEDAKQFYKVHSARPFYNDLCNYMSSGPIVAAALERDNA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 66392203  199 VKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEEL 254
Cdd:PRK14542  81 VLHWREVIGATDPKEAAAGTIRALYAESKEANAVHGSDSDANAALEISFFFKGNEL 136
PRK14540 PRK14540
nucleoside diphosphate kinase; Provisional
 5-108 3.30e-37

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184733  Cd Length: 134  Bit Score: 128.02  E-value: 3.30e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203    5 ERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVV 84
Cdd:PRK14540   3 ERTFVALKPDAVERKLIGKIIQRFENKGFEIVEMKMLKLTREMAEEYYEEHKGKEFYERLINFMTSGRIVAMVIEGENAI 82

                         90       100
                 ....*....|....*....|....
gi 66392203   85 KTGRVMLGETNPADSKPGTIRGDF 108
Cdd:PRK14540  83 STVRKMIGKTNPAEAEPGTIRGDF 106
PRK14541 PRK14541
nucleoside diphosphate kinase; Provisional
 119-255 1.04e-36

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173007  Cd Length: 140  Bit Score: 126.99  E-value: 1.04e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203  119 LERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNV 198
Cdd:PRK14541   1 MERTLTILKPDCVRKQLIGAVIDKIERAGFRVVAMKKTRLTKETAGEFYAVHRERPFYGELVEFMSSGPCVPMILEKENA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 66392203  199 VKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELV 255
Cdd:PRK14541  81 VADFRTLIGATDPAEAAEGTVRKLYADSKGENIVHGSDSAENAAIEAGFFFSAEEVV 137
PRK14545 PRK14545
nucleoside diphosphate kinase; Provisional
 121-253 1.87e-35

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184734  Cd Length: 139  Bit Score: 123.86  E-value: 1.87e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203  121 RTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVK 200
Cdd:PRK14545   5 RTFTMIKPDAVENGHIGGILDMITAAGFRIVAMKLTQLTVADAETFYAVHAERPFYGELVEFMSRGPIVAAILEKENAVE 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 66392203  201 TGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEE 253
Cdd:PRK14545  85 DFRTLIGATNPADAAEGTIRKKYAKSIGENAVHGSDSDENAQIEGAFHFAGRE 137
PRK14543 PRK14543
nucleoside diphosphate kinase; Provisional
 119-258 9.17e-33

nucleoside diphosphate kinase; Provisional


Pssm-ID: 237749  Cd Length: 169  Bit Score: 117.69  E-value: 9.17e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203  119 LERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYI--DLKDR---PFFPGLVKYMNSGPVVAMVW 193
Cdd:PRK14543   5 IQKTLCIIKPDGVRRGLIGNVVSRFERVGLKIVAAKMLLVDRSMAEKHYLydDIAVRhgeAVWKSLIKFISSSPVFVFVV 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 66392203  194 EGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGR----------NIIHGSDSVKSAEKEISLWFKPEELVDYK 258
Cdd:PRK14543  85 EGVESVEVVRKFCGSTEPKLAIPGTIRGDFSYHSFNyanekgfsvyNVIHASANEDDALREIPIWFKDNEILTYK 159
PRK14545 PRK14545
nucleoside diphosphate kinase; Provisional
 6-114 1.40e-27

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184734  Cd Length: 139  Bit Score: 103.45  E-value: 1.40e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203    6 RTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVVK 85
Cdd:PRK14545   5 RTFTMIKPDAVENGHIGGILDMITAAGFRIVAMKLTQLTVADAETFYAVHAERPFYGELVEFMSRGPIVAAILEKENAVE 84

                         90       100
                 ....*....|....*....|....*....
gi 66392203   86 TGRVMLGETNPADSKPGTIRGDFCIQVGR 114
Cdd:PRK14545  85 DFRTLIGATNPADAAEGTIRKKYAKSIGE 113
PRK14544 PRK14544
nucleoside diphosphate kinase; Provisional
 5-110 2.81e-27

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173010 [Multi-domain]  Cd Length: 183  Bit Score: 103.74  E-value: 2.81e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203    5 ERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHY----------------------VDLK-----D 57
Cdd:PRK14544   4 ERTLVILKPDAVKRGLVGEIISRFEKAGLKIVAMKMVKATPEQIERFYpsseewyrsvgnkllkayqelgIDPRarlgtD 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 66392203   58 RPFFAG------LVKYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCI 110
Cdd:PRK14544  84 DPVEVGkkvkesLVKYMTSGPIVAMVLKGNRAVEVVRKLVGPTSPHKAPPGTIRGDYSI 142
PLN02931 PLN02931
nucleoside diphosphate kinase family protein
 120-250 5.50e-27

nucleoside diphosphate kinase family protein


Pssm-ID: 215503  Cd Length: 177  Bit Score: 102.98  E-value: 5.50e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203  120 ERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVV 199
Cdd:PLN02931  30 ERTLAMIKPDGLSGNYTERIKEVILESGFSIVKEMTTQLDEDRASLFYAEHSSRSFFPSLVKYMTSGPVLVMVLEKENAV 109

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 66392203  200 KTGRVMLGETNPADSK---PGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFK 250
Cdd:PLN02931 110 SDWRTLIGPTDARKAKishPNSIRAMCGLDSEKNCVHGSDSPESAEREISFFFG 163
NDPk6 cd04414
Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced ...
 120-249 6.66e-27

Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has all nine residues considered crucial for enzyme structure and activity, and has been found to have NDP kinase activity. It may play a role in cell growth and cell cycle progression. The nm23-H6 gene locus has been implicated in a variety of malignant tumors.


Pssm-ID: 239877  Cd Length: 135  Bit Score: 101.32  E-value: 6.66e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203 120 ERTFIAIKPDGVQRGLVGEIIKRF-EQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNV 198
Cdd:cd04414   1 QLTLALIKPDAVAHPLALEAVRQLiLSNGFTIVRKKELRWTTEDAERFYAEHKGKFFYDRLVSFMTSGPSWALILAHENA 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 66392203 199 VKTGRVMLGETN---PADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWF 249
Cdd:cd04414  81 IKTWRALMGPTKvfrARASAPDSIRGLYGLTDTRNATHGSDSPASAQREIALFF 134
PRK14542 PRK14542
nucleoside diphosphate kinase; Provisional
 5-108 2.69e-26

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173008 [Multi-domain]  Cd Length: 137  Bit Score: 100.13  E-value: 2.69e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203    5 ERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVV 84
Cdd:PRK14542   2 SRTFIMIKPDGVKNKHVGNILQRIEKEGFKILGLKYLKLSLEDAKQFYKVHSARPFYNDLCNYMSSGPIVAAALERDNAV 81

                         90       100
                 ....*....|....*....|....
gi 66392203   85 KTGRVMLGETNPADSKPGTIRGDF 108
Cdd:PRK14542  82 LHWREVIGATDPKEAAAGTIRALY 105
NDPk7A cd04415
Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate ...
 120-249 3.26e-26

Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239878  Cd Length: 131  Bit Score: 99.44  E-value: 3.26e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203 120 ERTFIAIKPDGVQRglVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVV 199
Cdd:cd04415   1 EKTLALIKPDAYSK--IGKIIQIIEDAGFTITKAKMTKLSRKEAQDFYAEHQSKPFYNELVQFMTSGPIVAMELVGDDAI 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 66392203 200 KTGRVMLGETNPADSK---PGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWF 249
Cdd:cd04415  79 SEWRKLLGPTNSSVARsdaPNSIRALFGTDGTRNAAHGSDSVASAARELEFFF 131
NDPk5 cd04418
Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of ...
 120-250 3.74e-26

Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of p53-induced apoptosis-beta, IPIA-beta): In human, mRNA for NDPk5 is almost exclusively found in testis, especially in the flagella of spermatids and spermatozoa, in association with axoneme microtubules, and may play a role in spermatogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species. It belongs to the nm23 Group II genes and appears to differ from the other human NDPks in that it lacks two important catalytic site residues, and thus does not appear to possess NDP kinase activity. NDPk5 confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes, including glutathione peroxidase 5 (Gpx5).


Pssm-ID: 239880  Cd Length: 132  Bit Score: 99.44  E-value: 3.74e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203 120 ERTFIAIKPDGVQRglVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVV 199
Cdd:cd04418   1 ERTLAIIKPDAVHK--AEEIEDIILESGFTIVQKRKLQLSPEQCSDFYAEHYGKMFFPHLVAYMSSGPIVAMVLARHNAI 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 66392203 200 KTGRVMLGETNPADSK---PGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFK 250
Cdd:cd04418  79 SYWKELLGPTNSLKAKethPDSLRAIYGTDDLRNAVHGSDSFSSAEREIRFMFP 132
PRK14541 PRK14541
nucleoside diphosphate kinase; Provisional
 5-105 1.60e-23

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173007  Cd Length: 140  Bit Score: 92.70  E-value: 1.60e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203    5 ERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVV 84
Cdd:PRK14541   2 ERTLTILKPDCVRKQLIGAVIDKIERAGFRVVAMKKTRLTKETAGEFYAVHRERPFYGELVEFMSSGPCVPMILEKENAV 81

                         90       100
                 ....*....|....*....|.
gi 66392203   85 KTGRVMLGETNPADSKPGTIR 105
Cdd:PRK14541  82 ADFRTLIGATDPAEAAEGTVR 102
NDPk_TX cd04416
NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 ...
 120-249 9.59e-23

NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which has a tissue specific distribution in human testis, has been considered as a member of the nm23 family (nm23-H8) and exhibits a high homology with sea urchin IC1 (intermediate chain-1) protein, a component of the sperm axonemal outer dynein arm complex. Txl-2 is mainly represented in close association with microtubules within tissues with cilia and flagella such as seminiferous epithelium (spermatids) and lung airway epithelium, suggesting possible role in control of microtubule stability and maintenance.


Pssm-ID: 239879  Cd Length: 132  Bit Score: 90.35  E-value: 9.59e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203 120 ERTFIAIKPDGVQRGlVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVV 199
Cdd:cd04416   1 EYTLALIKPDAVAEK-KDEILEKIKEAGFEILAQKEMVLTEEQAREFYKEHEEEDYFEDLVEFMTSGPSLILVLSKENAV 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 66392203 200 KTGRVMLGETNPADSK---PGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWF 249
Cdd:cd04416  80 EEWRELMGPTDPEEAKeekPDSLRAQFARDHLSNAVHGSSSAEEAEKEIDFFF 132
PRK14543 PRK14543
nucleoside diphosphate kinase; Provisional
 5-108 1.33e-22

nucleoside diphosphate kinase; Provisional


Pssm-ID: 237749  Cd Length: 169  Bit Score: 91.11  E-value: 1.33e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203    5 ERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYV--DLKDR---PFFAGLVKYMHSGPVVAMVWE 79
Cdd:PRK14543   6 QKTLCIIKPDGVRRGLIGNVVSRFERVGLKIVAAKMLLVDRSMAEKHYLydDIAVRhgeAVWKSLIKFISSSPVFVFVVE 85

                         90       100
                 ....*....|....*....|....*....
gi 66392203   80 GLNVVKTGRVMLGETNPADSKPGTIRGDF 108
Cdd:PRK14543  86 GVESVEVVRKFCGSTEPKLAIPGTIRGDF 114
NDPk7B cd04412
Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate ...
 121-249 3.45e-20

Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239875  Cd Length: 134  Bit Score: 83.84  E-value: 3.45e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203 121 RTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLR----ASEEHLKqHYIDLKdrPFFPGLVKYMNSGPVVAMVWEGL 196
Cdd:cd04412   2 CTVCIIKPHAVSHGLLGEILQQILDEGFEITALQMFNltraNAEEFLE-VYKGVV--PELPAMVDELTSGPCIALEIAGE 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 66392203 197 NVVKTGRVMLGETNPADSK---PGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWF 249
Cdd:cd04412  79 NAVKTFREFCGPFDPEIAKqlrPNTLRARYGKDKVQNAVHCTDLPEDGPLELKFFF 134
NDPk7A cd04415
Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate ...
 5-108 1.02e-18

Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239878  Cd Length: 131  Bit Score: 79.80  E-value: 1.02e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203   5 ERTFIAIKPDGVQRglVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVV 84
Cdd:cd04415   1 EKTLALIKPDAYSK--IGKIIQIIEDAGFTITKAKMTKLSRKEAQDFYAEHQSKPFYNELVQFMTSGPIVAMELVGDDAI 78

                        90       100
                ....*....|....*....|....*..
gi 66392203  85 KTGRVMLGETNPADSK---PGTIRGDF 108
Cdd:cd04415  79 SEWRKLLGPTNSSVARsdaPNSIRALF 105
PLN02931 PLN02931
nucleoside diphosphate kinase family protein
 5-105 1.04e-15

nucleoside diphosphate kinase family protein


Pssm-ID: 215503  Cd Length: 177  Bit Score: 72.94  E-value: 1.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203    5 ERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVV 84
Cdd:PLN02931  30 ERTLAMIKPDGLSGNYTERIKEVILESGFSIVKEMTTQLDEDRASLFYAEHSSRSFFPSLVKYMTSGPVLVMVLEKENAV 109

                         90       100
                 ....*....|....*....|....
gi 66392203   85 KTGRVMLGETNPADSK---PGTIR 105
Cdd:PLN02931 110 SDWRTLIGPTDARKAKishPNSIR 133
NDPk5 cd04418
Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of ...
 5-105 9.67e-15

Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of p53-induced apoptosis-beta, IPIA-beta): In human, mRNA for NDPk5 is almost exclusively found in testis, especially in the flagella of spermatids and spermatozoa, in association with axoneme microtubules, and may play a role in spermatogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species. It belongs to the nm23 Group II genes and appears to differ from the other human NDPks in that it lacks two important catalytic site residues, and thus does not appear to possess NDP kinase activity. NDPk5 confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes, including glutathione peroxidase 5 (Gpx5).


Pssm-ID: 239880  Cd Length: 132  Bit Score: 69.00  E-value: 9.67e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203   5 ERTFIAIKPDGVQRglVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVV 84
Cdd:cd04418   1 ERTLAIIKPDAVHK--AEEIEDIILESGFTIVQKRKLQLSPEQCSDFYAEHYGKMFFPHLVAYMSSGPIVAMVLARHNAI 78

                        90       100
                ....*....|....*....|....
gi 66392203  85 KTGRVMLGETNPADSK---PGTIR 105
Cdd:cd04418  79 SYWKELLGPTNSLKAKethPDSLR 102
NDPk7B cd04412
Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate ...
 3-108 1.47e-13

Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239875  Cd Length: 134  Bit Score: 66.12  E-value: 1.47e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203   3 NCerTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKD-RPFFAGLVKYMHSGPVVAMVWEGL 81
Cdd:cd04412   1 NC--TVCIIKPHAVSHGLLGEILQQILDEGFEITALQMFNLTRANAEEFLEVYKGvVPELPAMVDELTSGPCIALEIAGE 78

                        90       100       110
                ....*....|....*....|....*....|
gi 66392203  82 NVVKTGRVMLGETNPADSK---PGTIRGDF 108
Cdd:cd04412  79 NAVKTFREFCGPFDPEIAKqlrPNTLRARY 108
NDPk6 cd04414
Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced ...
 5-108 3.77e-12

Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has all nine residues considered crucial for enzyme structure and activity, and has been found to have NDP kinase activity. It may play a role in cell growth and cell cycle progression. The nm23-H6 gene locus has been implicated in a variety of malignant tumors.


Pssm-ID: 239877  Cd Length: 135  Bit Score: 62.03  E-value: 3.77e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203   5 ERTFIAIKPDGVQRGLVGEIIKRF-EQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNV 83
Cdd:cd04414   1 QLTLALIKPDAVAHPLALEAVRQLiLSNGFTIVRKKELRWTTEDAERFYAEHKGKFFYDRLVSFMTSGPSWALILAHENA 80

                        90       100
                ....*....|....*....|....*...
gi 66392203  84 VKTGRVMLGETN---PADSKPGTIRGDF 108
Cdd:cd04414  81 IKTWRALMGPTKvfrARASAPDSIRGLY 108
NDPk_TX cd04416
NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 ...
 5-112 7.08e-12

NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which has a tissue specific distribution in human testis, has been considered as a member of the nm23 family (nm23-H8) and exhibits a high homology with sea urchin IC1 (intermediate chain-1) protein, a component of the sperm axonemal outer dynein arm complex. Txl-2 is mainly represented in close association with microtubules within tissues with cilia and flagella such as seminiferous epithelium (spermatids) and lung airway epithelium, suggesting possible role in control of microtubule stability and maintenance.


Pssm-ID: 239879  Cd Length: 132  Bit Score: 61.46  E-value: 7.08e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392203   5 ERTFIAIKPDGVQRGlVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVV 84
Cdd:cd04416   1 EYTLALIKPDAVAEK-KDEILEKIKEAGFEILAQKEMVLTEEQAREFYKEHEEEDYFEDLVEFMTSGPSLILVLSKENAV 79

                        90       100       110
                ....*....|....*....|....*....|.
gi 66392203  85 KTGRVMLGETNPADSK---PGTIRGDFCIQV 112
Cdd:cd04416  80 EEWRELMGPTDPEEAKeekPDSLRAQFARDH 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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