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Conserved domains on  [gi|65787364|ref|NP_001018080|]
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coronin-1B [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-485 1.60e-107

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 328.39  E-value: 1.60e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364   10 SKFRHVFGQPVKNDQCYEDIRVSRVTWD-STFCAVNPKFLAVIVEASGGGAflVLPLSKTGRIDKAYPTVCGHTGPVLDI 88
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364   89 DWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNV--GTAE 166
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVerGKAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364  167 ELYrldSLHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEREkAHEGARPMRAIFLADGK-VFTTGFSRMSER 245
Cdd:PTZ00421 162 EVI---KCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQR 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364  246 QLALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITEEPpyIHFLNTFTSKEPQRGMGSMPKR 325
Cdd:PTZ00421 238 QIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMPKW 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364  326 GLEVSKCEIARFYKLHERKCEPIVMTVPRK-SDL-FQDDLYPDTAGPEAALEAEEWVSGRDADPILISLREAY---VPSK 400
Cdd:PTZ00421 316 SLDTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAVFdgtSPEL 395

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364  401 QRDLKISRRNVLSDSRPAMAPGSSHLGAPASTTTAADATPSGSLARAGEAGKLEEVMQELRALRALVKEQGDRICRLEEQ 480
Cdd:PTZ00421 396 MGASALSPSGKPRHSGVSVPASTSAMTHSFDDNTSKHADPCAMGVKRMDEGILDERLGRLQALSEKLRTQHEEIKRCREA 475


                 ....*
gi 65787364  481 LGRME 485
Cdd:PTZ00421 476 LQKKE 480
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 10-485 1.60e-107

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 328.39  E-value: 1.60e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364   10 SKFRHVFGQPVKNDQCYEDIRVSRVTWD-STFCAVNPKFLAVIVEASGGGAflVLPLSKTGRIDKAYPTVCGHTGPVLDI 88
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364   89 DWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNV--GTAE 166
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVerGKAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364  167 ELYrldSLHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEREkAHEGARPMRAIFLADGK-VFTTGFSRMSER 245
Cdd:PTZ00421 162 EVI---KCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQR 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364  246 QLALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITEEPpyIHFLNTFTSKEPQRGMGSMPKR 325
Cdd:PTZ00421 238 QIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMPKW 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364  326 GLEVSKCEIARFYKLHERKCEPIVMTVPRK-SDL-FQDDLYPDTAGPEAALEAEEWVSGRDADPILISLREAY---VPSK 400
Cdd:PTZ00421 316 SLDTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAVFdgtSPEL 395

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364  401 QRDLKISRRNVLSDSRPAMAPGSSHLGAPASTTTAADATPSGSLARAGEAGKLEEVMQELRALRALVKEQGDRICRLEEQ 480
Cdd:PTZ00421 396 MGASALSPSGKPRHSGVSVPASTSAMTHSFDDNTSKHADPCAMGVKRMDEGILDERLGRLQALSEKLRTQHEEIKRCREA 475


                 ....*
gi 65787364  481 LGRME 485
Cdd:PTZ00421 476 LQKKE 480
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 5-70 1.80e-37

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 131.47  E-value: 1.80e-37
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 65787364     5 KVVRQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAFLVLPLSKTGR 70
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 77-297 1.23e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.04  E-value: 1.23e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364  77 TVCGHTGPVLDIDWCPHnDEVIASGSEDCTVMVWQIPENgltspltEPVVVLEGHTKRVGIIAWHPTARnVLLSAGCDNV 156
Cdd:cd00200  46 TLKGHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLETG-------ECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKT 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364 157 VLIWNVGTAEELYRLDSlHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEREkAHEGarPMRAI-FLADGKVF 235
Cdd:cd00200 117 IKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLT-GHTG--EVNSVaFSPDGEKL 192

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 65787364 236 TTGFsrmSERQLALWDpenLEEPMALQELDSSNGALL-PFYDPDTSVVyVCGKGDSSIRYFEI 297
Cdd:cd00200 193 LSSS---SDGTIKLWD---LSTGKCLGTLRGHENGVNsVAFSPDGYLL-ASGSEDGTIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
77-262 1.22e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.68  E-value: 1.22e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364  77 TVCGHTGPVLDIDWCPhNDEVIASGSEDCTVMVWQIPENgltspltEPVVVLEGHTKRVGIIAWHPTARnVLLSAGCDNV 156
Cdd:COG2319 199 TLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATG-------KLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGT 269

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364 157 VLIWNVGTAEELYRLDSlHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEReKAHEGARpmRAI-FLADGKVF 235
Cdd:COG2319 270 VRLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAV--RSVaFSPDGKTL 345

                       170       180
                ....*....|....*....|....*..
gi 65787364 236 TTGFsrmSERQLALWDPENLEEPMALQ 262
Cdd:COG2319 346 ASGS---DDGTVRLWDLATGELLRTLT 369
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 80-110 6.16e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 6.16e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 65787364     80 GHTGPVLDIDWCPhNDEVIASGSEDCTVMVW 110
Cdd:smart00320  10 GHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 10-485 1.60e-107

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 328.39  E-value: 1.60e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364   10 SKFRHVFGQPVKNDQCYEDIRVSRVTWD-STFCAVNPKFLAVIVEASGGGAflVLPLSKTGRIDKAYPTVCGHTGPVLDI 88
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364   89 DWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNV--GTAE 166
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVerGKAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364  167 ELYrldSLHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEREkAHEGARPMRAIFLADGK-VFTTGFSRMSER 245
Cdd:PTZ00421 162 EVI---KCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQR 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364  246 QLALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITEEPpyIHFLNTFTSKEPQRGMGSMPKR 325
Cdd:PTZ00421 238 QIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMPKW 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364  326 GLEVSKCEIARFYKLHERKCEPIVMTVPRK-SDL-FQDDLYPDTAGPEAALEAEEWVSGRDADPILISLREAY---VPSK 400
Cdd:PTZ00421 316 SLDTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAVFdgtSPEL 395

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364  401 QRDLKISRRNVLSDSRPAMAPGSSHLGAPASTTTAADATPSGSLARAGEAGKLEEVMQELRALRALVKEQGDRICRLEEQ 480
Cdd:PTZ00421 396 MGASALSPSGKPRHSGVSVPASTSAMTHSFDDNTSKHADPCAMGVKRMDEGILDERLGRLQALSEKLRTQHEEIKRCREA 475


                 ....*
gi 65787364  481 LGRME 485
Cdd:PTZ00421 476 LQKKE 480
PTZ00420 PTZ00420
coronin; Provisional
 19-409 1.20e-68

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 229.45  E-value: 1.20e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364   19 PVKNDQCYEDIRV-SRVTwDSTFCAVNPKFLAVIVEASGGGAFLVLPLSKTGRidkaYPTVC---GHTGPVLDIDWCPHN 94
Cdd:PTZ00420  12 PDPSNNLFDDLRIcSRVI-DSCGIACSSGFVAVPWEVEGGGLIGAIRLENQMR----KPPVIklkGHTSSILDLQFNPCF 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364   95 DEVIASGSEDCTVMVWQIPENGLT-SPLTEPVVVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLds 173
Cdd:PTZ00420  87 SEILASGSEDLTIRVWEIPHNDESvKEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQI-- 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364  174 LHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTlVAEREKAHEGARPMRAIFL-----ADGKVFTTGFSRMSERQLA 248
Cdd:PTZ00420 165 NMPKKLSSLKWNIKGNLLSGTCVGKHMHIIDPRKQE-IASSFHIHDGGKNTKNIWIdglggDDNYILSTGFSKNNMREMK 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364  249 LWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITEEPpyIHFLNTFTSKEPQRGMGSMPKRGLE 328
Cdd:PTZ00420 244 LWDLKNTTSALVTMSIDNASAPLIPHYDESTGLIYLIGKGDGNCRYYQHSLGS--IRKVNEYKSCSPFRSFGFLPKQICD 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364  329 VSKCEIARFYK-LHERKCEPIVMTVPRK-SDLFQDDLYPDTAGPEAALEAEEWVSGRDADPILISLREAyvpsKQRDLKI 406
Cdd:PTZ00420 322 VYKCEIGRVYKnENNSSIRPISFYVPRKnPTKFQEDLYPPILMHDPERSSRNWIDGKDNKMKRINIKDL----TEDDLRI 397


                 ...
gi 65787364  407 SRR 409
Cdd:PTZ00420 398 TKK 400
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 5-70 1.80e-37

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 131.47  E-value: 1.80e-37
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 65787364     5 KVVRQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAFLVLPLSKTGR 70
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 77-297 1.23e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.04  E-value: 1.23e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364  77 TVCGHTGPVLDIDWCPHnDEVIASGSEDCTVMVWQIPENgltspltEPVVVLEGHTKRVGIIAWHPTARnVLLSAGCDNV 156
Cdd:cd00200  46 TLKGHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLETG-------ECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKT 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364 157 VLIWNVGTAEELYRLDSlHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEREkAHEGarPMRAI-FLADGKVF 235
Cdd:cd00200 117 IKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLT-GHTG--EVNSVaFSPDGEKL 192

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 65787364 236 TTGFsrmSERQLALWDpenLEEPMALQELDSSNGALL-PFYDPDTSVVyVCGKGDSSIRYFEI 297
Cdd:cd00200 193 LSSS---SDGTIKLWD---LSTGKCLGTLRGHENGVNsVAFSPDGYLL-ASGSEDGTIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
77-262 1.22e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.68  E-value: 1.22e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364  77 TVCGHTGPVLDIDWCPhNDEVIASGSEDCTVMVWQIPENgltspltEPVVVLEGHTKRVGIIAWHPTARnVLLSAGCDNV 156
Cdd:COG2319 199 TLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATG-------KLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGT 269

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364 157 VLIWNVGTAEELYRLDSlHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEReKAHEGARpmRAI-FLADGKVF 235
Cdd:COG2319 270 VRLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAV--RSVaFSPDGKTL 345

                       170       180
                ....*....|....*....|....*..
gi 65787364 236 TTGFsrmSERQLALWDPENLEEPMALQ 262
Cdd:COG2319 346 ASGS---DDGTVRLWDLATGELLRTLT 369
WD40 COG2319
WD40 repeat [General function prediction only];
80-293 1.67e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.30  E-value: 1.67e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364  80 GHTGPVLDIDWCPhNDEVIASGSEDCTVMVWQIpENGltspltEPVVVLEGHTKRVGIIAWHPTARnVLLSAGCDNVVLI 159
Cdd:COG2319 118 GHTGAVRSVAFSP-DGKTLASGSADGTVRLWDL-ATG------KLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRL 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364 160 WNVGTAEELYRLDSlHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEREkaHEGARPMRAIFLADGKVFTTGf 239
Cdd:COG2319 189 WDLATGKLLRTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT--GHSGSVRSVAFSPDGRLLASG- 264

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 65787364 240 srMSERQLALWDPENLEEpmaLQELDSSNGALLPF-YDPDTSVVyVCGKGDSSIR 293
Cdd:COG2319 265 --SADGTVRLWDLATGEL---LRTLTGHSGGVNSVaFSPDGKLL-ASGSDDGTVR 313
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-238 5.45e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.56  E-value: 5.45e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364  80 GHTGPVLDIDWCPHNDeVIASGSEDCTVMVWQIPENgltspltEPVVVLEGHTKRVGIIAWHPTARNvLLSAGCDNVVLI 159
Cdd:cd00200 133 GHTDWVNSVAFSPDGT-FVASSSQDGTIKLWDLRTG-------KCVATLTGHTGEVNSVAFSPDGEK-LLSSSSDGTIKL 203

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364 160 WNVGTAEELYRLDSlHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEReKAHEGarPMRAI-FLADGKVFTTG 238
Cdd:cd00200 204 WDLSTGKCLGTLRG-HENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL-SGHTN--SVTSLaWSPDGKRLASG 279
WD40 COG2319
WD40 repeat [General function prediction only];
80-206 1.59e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.36  E-value: 1.59e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364  80 GHTGPVLDIDWCPhNDEVIASGSEDCTVMVWQIPENgltspltEPVVVLEGHTKRVGIIAWHPTARnVLLSAGCDNVVLI 159
Cdd:COG2319 286 GHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATG-------KLLRTLTGHTGAVRSVAFSPDGK-TLASGSDDGTVRL 356

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 65787364 160 WNVGTAEELYRLDSlHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPR 206
Cdd:COG2319 357 WDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 345-387 5.49e-19

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 80.25  E-value: 5.49e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 65787364   345 CEPIVMTVPRKS-DLFQDDLYPDTAGPEAALEAEEWVSGRDADP 387
Cdd:pfam16300   1 IEPISFTVPRKSkEDFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-202 3.82e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 84.69  E-value: 3.82e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364  80 GHTGPVLDIDWCPhNDEVIASGSEDCTVMVWQIPEngltsplTEPVVVLEGHTKRVGIIAWHPTaRNVLLSAGCDNVVLI 159
Cdd:cd00200 175 GHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLST-------GKCLGTLRGHENGVNSVAFSPD-GYLLASGSEDGTIRV 245

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 65787364 160 WNVGTAEELYRLdSLHPDLIYNVSWNHNGSLFCSACKDKSVRI 202
Cdd:cd00200 246 WDLRTGECVQTL-SGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 127-293 1.27e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.21  E-value: 1.27e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364 127 VLEGHTKRVGIIAWHPTaRNVLLSAGCDNVVLIWNVGTAEELYRLdSLHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPR 206
Cdd:cd00200   4 TLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364 207 RGTLVaeRE-KAHEGarPMRAI-FLADGKVFTTGfsrMSERQLALWDpenLEEPMALQELDS-SNGALLPFYDPDTSVVy 283
Cdd:cd00200  82 TGECV--RTlTGHTS--YVSSVaFSPDGRILSSS---SRDKTIKVWD---VETGKCLTTLRGhTDWVNSVAFSPDGTFV- 150

                       170
                ....*....|
gi 65787364 284 VCGKGDSSIR 293
Cdd:cd00200 151 ASSSQDGTIK 160
WD40 COG2319
WD40 repeat [General function prediction only];
80-164 3.31e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.85  E-value: 3.31e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364  80 GHTGPVLDIDWCPhNDEVIASGSEDCTVMVWQIPENGLtspltepVVVLEGHTKRVGIIAWHPTARnVLLSAGCDNVVLI 159
Cdd:COG2319 328 GHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGEL-------LRTLTGHTGAVTSVAFSPDGR-TLASGSADGTVRL 398


                ....*
gi 65787364 160 WNVGT 164
Cdd:COG2319 399 WDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 80-110 6.16e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 6.16e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 65787364     80 GHTGPVLDIDWCPhNDEVIASGSEDCTVMVW 110
Cdd:smart00320  10 GHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
77-110 4.41e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 4.41e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 65787364    77 TVCGHTGPVLDIDWCPhNDEVIASGSEDCTVMVW 110
Cdd:pfam00400   6 TLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 123-161 1.87e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 1.87e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 65787364    123 EPVVVLEGHTKRVGIIAWHPTaRNVLLSAGCDNVVLIWN 161
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 175-298 3.69e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.40  E-value: 3.69e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65787364 175 HPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAeREKAHEGarPMRAI-FLADGK-VFTTGfsrmSERQLALWDP 252
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR-TLKGHTG--PVRDVaASADGTyLASGS----SDKTIRLWDL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 65787364 253 ENLEEpmaLQELDSSNGALL-PFYDPDTSVVyVCGKGDSSIRYFEIT 298
Cdd:cd00200  81 ETGEC---VRTLTGHTSYVSsVAFSPDGRIL-SSSSRDKTIKVWDVE 123
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 175-204 1.91e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.91e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 65787364    175 HPDLIYNVSWNHNGSLFCSACKDKSVRIID 204
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
123-161 2.13e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 2.13e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 65787364   123 EPVVVLEGHTKRVGIIAWHPTaRNVLLSAGCDNVVLIWN 161
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 66-111 7.68e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.55  E-value: 7.68e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 65787364  66 SKTGRIDKaypTVCGHTGPVLDIDWCPHNDeVIASGSEDCTVMVWQ 111
Cdd:cd00200 248 LRTGECVQ---TLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
175-204 1.75e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.75e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 65787364   175 HPDLIYNVSWNHNGSLFCSACKDKSVRIID 204
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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