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Conserved domains on  [gi|62953120|ref|NP_001017525|]
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ankyrin repeat and BTB/POZ domain-containing protein 3 isoform 2 [Mus musculus]

Protein Classification

ankyrin repeat and BTB/POZ domain-containing protein BTBD11( domain architecture ID 18454188)

ankyrin repeat and BTB/POZ domain-containing protein BTBD11

Gene Symbol:  BTBD11
Gene Ontology:  GO:0005515
PubMed:  15544948|27521773|17176038|17120193

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 435-565 3.77e-97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 293.42  E-value: 3.77e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 435 PKLTEIKRKQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTCIEIGYVKYPIFQLVMQ 514
Cdd:cd18351   1 PKLTEIKRKQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSNKPSAENTCIEISYVKYHIFQLVMQ 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 62953120 515 YLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCVD 565
Cdd:cd18351  81 YLYCGGTESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTENCVD 131
BACK_BTBD11 cd18527
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 11 (BTBD11); ...
 558-640 1.51e-50

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also termed ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. The BTBD11 gene has been identified as an all-trans retinoic acid-responsive gene that may play a role in neural development.


:

Pssm-ID: 350602  Cd Length: 83  Bit Score: 169.62  E-value: 1.51e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 558 INTDNCVDIYSHAKFLGVTELSAYCEGYFLKNMMVLIENEAFKQLLYDKNGEGAGQDVLQDLQRTLAIRIQSIHLSSSKG 637
Cdd:cd18527   1 INTENCVDIYNHAKFLGATELSSYCEGYFLKNMVLLIENEAFKQLLYDKNGESPGQDVLQDLERTLATRIQSIHLSSSKG 80


                ...
gi 62953120 638 SVV 640
Cdd:cd18527  81 SIV 83
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
116-289 8.68e-29

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 116.59  E-value: 8.68e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 116 GRTDLVKQAVSLlGPDgINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVevvstphkypsvhPETRHWTALTFAVL 195
Cdd:COG0666  98 GDLEIVKLLLEA-GAD-VNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNA-------------QDNDGNTPLHLAAA 162

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 196 HGHIPVVQLLLDAGAKVEGSVEHGeenysETPLQLAAAVGNFELVSLLLERGADPLIgtmyRNGISTTPqgdmnsFSQAA 275
Cdd:COG0666 163 NGNLEIVKLLLEAGADVNARDNDG-----ETPLHLAAENGHLEIVKLLLEAGADVNA----KDNDGKTA------LDLAA 227

                       170
                ....*....|....
gi 62953120 276 AHGHRNVFRKLLAQ 289
Cdd:COG0666 228 ENGNLEIVKLLLEA 241
 
Name Accession Description Interval E-value
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 435-565 3.77e-97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 293.42  E-value: 3.77e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 435 PKLTEIKRKQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTCIEIGYVKYPIFQLVMQ 514
Cdd:cd18351   1 PKLTEIKRKQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSNKPSAENTCIEISYVKYHIFQLVMQ 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 62953120 515 YLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCVD 565
Cdd:cd18351  81 YLYCGGTESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTENCVD 131
BACK_BTBD11 cd18527
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 11 (BTBD11); ...
 558-640 1.51e-50

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also termed ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. The BTBD11 gene has been identified as an all-trans retinoic acid-responsive gene that may play a role in neural development.


Pssm-ID: 350602  Cd Length: 83  Bit Score: 169.62  E-value: 1.51e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 558 INTDNCVDIYSHAKFLGVTELSAYCEGYFLKNMMVLIENEAFKQLLYDKNGEGAGQDVLQDLQRTLAIRIQSIHLSSSKG 637
Cdd:cd18527   1 INTENCVDIYNHAKFLGATELSSYCEGYFLKNMVLLIENEAFKQLLYDKNGESPGQDVLQDLERTLATRIQSIHLSSSKG 80


                ...
gi 62953120 638 SVV 640
Cdd:cd18527  81 SIV 83
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
116-289 8.68e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 116.59  E-value: 8.68e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 116 GRTDLVKQAVSLlGPDgINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVevvstphkypsvhPETRHWTALTFAVL 195
Cdd:COG0666  98 GDLEIVKLLLEA-GAD-VNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNA-------------QDNDGNTPLHLAAA 162

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 196 HGHIPVVQLLLDAGAKVEGSVEHGeenysETPLQLAAAVGNFELVSLLLERGADPLIgtmyRNGISTTPqgdmnsFSQAA 275
Cdd:COG0666 163 NGNLEIVKLLLEAGADVNARDNDG-----ETPLHLAAENGHLEIVKLLLEAGADVNA----KDNDGKTA------LDLAA 227

                       170
                ....*....|....
gi 62953120 276 AHGHRNVFRKLLAQ 289
Cdd:COG0666 228 ENGNLEIVKLLLEA 241
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 451-558 3.36e-23

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 94.63  E-value: 3.36e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120   451 HFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTC-IEIGYVKYPIFQLVMQYLYYGgpesLLIKNN 529
Cdd:pfam00651   3 ELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSeITLDDVSPEDFEALLEFMYTG----KLISEE 78

                          90       100
                  ....*....|....*....|....*....
gi 62953120   530 EIMELLSAAKFFQLEALQRHCEIICAKSI 558
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 460-558 3.46e-20

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 85.82  E-value: 3.46e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120    460 DVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDN-TCIEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNEIMELLSAA 538
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDkSEIYLDDVSPEDFRALLNFLYTG---KLDLPEENVEELLELA 77

                           90       100
                   ....*....|....*....|
gi 62953120    539 KFFQLEALQRHCEIICAKSI 558
Cdd:smart00225  78 DYLQIPGLVELCEEFLLKLL 97
Ank_2 pfam12796
Ankyrin repeats (3 copies);
144-250 7.04e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 73.23  E-value: 7.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120   144 LMYACVRGDEAMVQMLLDAGADLNVEvvstphkypsvhpETRHWTALTFAVLHGHIPVVQLLLDAGAKvegsvehGEENY 223
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQ-------------DKNGRTALHLAAKNGHLEIVKLLLEHADV-------NLKDN 60

                          90       100
                  ....*....|....*....|....*..
gi 62953120   224 SETPLQLAAAVGNFELVSLLLERGADP 250
Cdd:pfam12796  61 GRTALHYAARSGHLEIVKLLLEKGADI 87
PHA03098 PHA03098
kelch-like protein; Provisional
 457-605 2.14e-11

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 66.71  E-value: 2.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120  457 EMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTCIeigYVKYPIFQLVMQYLYYGgpeSLLIKNNEIMELLS 536
Cdd:PHA03098  10 CDESIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENEINL---NIDYDSFNEVIKYIYTG---KINITSNNVKDILS 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62953120  537 AAKFFQLEALQRHCEIICAKSINTDNCVDIYSHAKFLGVTELSAYCEGYFLKNMMVLIENEAFKQLLYD 605
Cdd:PHA03098  84 IANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKN 152
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 138-250 2.20e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 53.46  E-value: 2.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120  138 EQGMTPLMYACVRGDEAMVQMLLDAGADLNVevvstphkypsvhPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGsve 217
Cdd:PHA02875 100 KDGMTPLHLATILKKLDIMKLLIARGADPDI-------------PNTDKFSPLHLAVMMGDIKGIELLIDHKACLDI--- 163

                         90       100       110
                 ....*....|....*....|....*....|...
gi 62953120  218 hgEENYSETPLQLAAAVGNFELVSLLLERGADP 250
Cdd:PHA02875 164 --EDCCGCTPLIIAMAKGDIAICKMLLDSGANI 194
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 139-168 1.37e-06

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 44.89  E-value: 1.37e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 62953120    139 QGMTPLMYACVRGDEAMVQMLLDAGADLNV 168
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 89-250 2.91e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 50.40  E-value: 2.91e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120  89 FCASRKLDAVAIEakfkqdlgfRMLNCGRTDLVKQAVsllgpdgintmseQGMTPLMYACVRGDEAMVQMLLDAGADL-N 167
Cdd:cd22192  22 LLAAKENDVQAIK---------KLLKCPSCDLFQRGA-------------LGETALHVAALYDNLEAAVVLMEAAPELvN 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 168 VEVVSTPHKYPsvhpetrhwTALTFAVLHGHIPVVQLLLDAGAKVE-----GSV----EHGEENYSETPLQLAAAVGNFE 238
Cdd:cd22192  80 EPMTSDLYQGE---------TALHIAVVNQNLNLVRELIARGADVVspratGTFfrpgPKNLIYYGEHPLSFAACVGNEE 150

                       170
                ....*....|..
gi 62953120 239 LVSLLLERGADP 250
Cdd:cd22192 151 IVRLLIEHGADI 162
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 149-251 1.43e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 48.15  E-value: 1.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120   149 VRGDEAMVQMLLDAGAdlnvEVVSTPHKY-PSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGS------VEHGEE 221
Cdd:TIGR00870  94 VDAVEAILLHLLAAFR----KSGPLELANdQYTSEFTPGITALHLAAHRQNYEIVKLLLERGASVPARacgdffVKSQGV 169

                          90       100       110
                  ....*....|....*....|....*....|...
gi 62953120   222 N---YSETPLQLAAAVGNFELVSLLLERGADPL 251
Cdd:TIGR00870 170 DsfyHGESPLNAAACLGSPSIVALLSEDPADIL 202
 
Name Accession Description Interval E-value
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 435-565 3.77e-97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 293.42  E-value: 3.77e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 435 PKLTEIKRKQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTCIEIGYVKYPIFQLVMQ 514
Cdd:cd18351   1 PKLTEIKRKQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSNKPSAENTCIEISYVKYHIFQLVMQ 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 62953120 515 YLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCVD 565
Cdd:cd18351  81 YLYCGGTESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTENCVD 131
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 447-562 1.26e-65

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 210.98  E-value: 1.26e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 447 RLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPT-NDNTCIEIGYVKYPIFQLVMQYLYYGGPESLL 525
Cdd:cd18297   1 RIDPHYVNNPEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTeAQTPVIEIPDIRYDIFQLMMQYLYTGGVESLD 80

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 62953120 526 IKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDN 562
Cdd:cd18297  81 VAQDDALELLRAASFFQLDGLKRHCEILLSQQIDLDN 117
BTB_POZ_ABTB2_BPOZ2 cd18350
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 435-564 5.68e-62

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349659 [Multi-domain]  Cd Length: 134  Bit Score: 202.00  E-value: 5.68e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 435 PKLTEIKRKQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNT---CIEIGYVKYPIFQL 511
Cdd:cd18350   1 PSIPEIRKTLPARLDPHFLNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKSLLTNKSEQESQgskTIEISDIKYHIFQM 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 62953120 512 VMQYLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCV 564
Cdd:cd18350  81 LMQYLYYGGTESMEIPIADVLELLSAASLFQLDALQRHCEILCSQTINLENAV 133
BACK_BTBD11 cd18527
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 11 (BTBD11); ...
 558-640 1.51e-50

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also termed ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. The BTBD11 gene has been identified as an all-trans retinoic acid-responsive gene that may play a role in neural development.


Pssm-ID: 350602  Cd Length: 83  Bit Score: 169.62  E-value: 1.51e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 558 INTDNCVDIYSHAKFLGVTELSAYCEGYFLKNMMVLIENEAFKQLLYDKNGEGAGQDVLQDLQRTLAIRIQSIHLSSSKG 637
Cdd:cd18527   1 INTENCVDIYNHAKFLGATELSSYCEGYFLKNMVLLIENEAFKQLLYDKNGESPGQDVLQDLERTLATRIQSIHLSSSKG 80


                ...
gi 62953120 638 SVV 640
Cdd:cd18527  81 SIV 83
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
116-289 8.68e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 116.59  E-value: 8.68e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 116 GRTDLVKQAVSLlGPDgINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVevvstphkypsvhPETRHWTALTFAVL 195
Cdd:COG0666  98 GDLEIVKLLLEA-GAD-VNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNA-------------QDNDGNTPLHLAAA 162

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 196 HGHIPVVQLLLDAGAKVEGSVEHGeenysETPLQLAAAVGNFELVSLLLERGADPLIgtmyRNGISTTPqgdmnsFSQAA 275
Cdd:COG0666 163 NGNLEIVKLLLEAGADVNARDNDG-----ETPLHLAAENGHLEIVKLLLEAGADVNA----KDNDGKTA------LDLAA 227

                       170
                ....*....|....
gi 62953120 276 AHGHRNVFRKLLAQ 289
Cdd:COG0666 228 ENGNLEIVKLLLEA 241
BACK_ABTB2_like cd18491
BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing ...
 558-630 2.05e-28

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; ABTB2, also called Bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins involved in a range of functions from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications in Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homologue (PTEN). This subfamily also includes BTB/POZ domain-containing protein 11 (BTBD11), whose function is unclear.


Pssm-ID: 350566  Cd Length: 72  Bit Score: 108.14  E-value: 2.05e-28
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62953120 558 INTDNCVDIYSHAKFLGVTELSAYCEGYFLKNMM-VLIENEAFKQLLYDKNGEgaGQDVLQDLQRTLAIRIQSI 630
Cdd:cd18491   1 LDLDNVVAIYKHAKLYNAPELLAYCEGYFLQNMVqLLLENDSFRKLLFGKKLH--GHDVLQGLQATLTQRIQSR 72
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
95-289 5.33e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 114.28  E-value: 5.33e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120  95 LDAVAIEAKFKQDLGFRMLNCGRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVevvstp 174
Cdd:COG0666  42 LALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNA------ 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 175 hkypsvhPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGeenysETPLQLAAAVGNFELVSLLLERGADPLIgt 254
Cdd:COG0666 116 -------RDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDG-----NTPLHLAAANGNLEIVKLLLEAGADVNA-- 181

                       170       180       190
                ....*....|....*....|....*....|....*
gi 62953120 255 myRNGISTTPqgdmnsFSQAAAHGHRNVFRKLLAQ 289
Cdd:COG0666 182 --RDNDGETP------LHLAAENGHLEIVKLLLEA 208
BACK_ABTB2 cd18526
BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing ...
 558-634 1.31e-26

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called Bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications in Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homologue (PTEN).


Pssm-ID: 350601  Cd Length: 79  Bit Score: 103.37  E-value: 1.31e-26
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62953120 558 INTDNCVDIYSHAKFLGVTELSAYCEGYFLKNMMVLIENEAFKQLLYDKNGEGAGQDVLQDLQRTLAIRIQSIHLSS 634
Cdd:cd18526   1 INLENSVSIYKYAKIHNAPELASFCEGFFLKNMKALLEQDSFRQLIYGRNSKVQGLDPLQDLQVTLAKRMHSIYITS 77
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
116-252 6.80e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 105.04  E-value: 6.80e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 116 GRTDLVKQavsLL--GPDgINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNvevvstphkypsvHPETRHWTALTFA 193
Cdd:COG0666 131 GNLEIVKL---LLeaGAD-VNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVN-------------ARDNDGETPLHLA 193

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 62953120 194 VLHGHIPVVQLLLDAGAKVegsveHGEENYSETPLQLAAAVGNFELVSLLLERGADPLI 252
Cdd:COG0666 194 AENGHLEIVKLLLEAGADV-----NAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNA 247
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 451-558 3.36e-23

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 94.63  E-value: 3.36e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120   451 HFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTC-IEIGYVKYPIFQLVMQYLYYGgpesLLIKNN 529
Cdd:pfam00651   3 ELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSeITLDDVSPEDFEALLEFMYTG----KLISEE 78

                          90       100
                  ....*....|....*....|....*....
gi 62953120   530 EIMELLSAAKFFQLEALQRHCEIICAKSI 558
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 448-562 5.30e-21

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 88.69  E-value: 5.30e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 448 LDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSK-PTNDNTCIEIGYVKYPIFQLVMQYLYYGgpeSLLI 526
Cdd:cd18352   3 LGEQYVNNATLSDVTFLVEGRRFYAHRIALLASSDAFRAMFDGGyREKEARDIEIPNIRWEVFELMMRFIYTG---SVDI 79

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 62953120 527 KNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDN 562
Cdd:cd18352  80 TNDIAKDLLRAADQYLLEGLKRLCEYTIAQDLTLEN 115
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 460-558 3.46e-20

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 85.82  E-value: 3.46e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120    460 DVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDN-TCIEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNEIMELLSAA 538
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDkSEIYLDDVSPEDFRALLNFLYTG---KLDLPEENVEELLELA 77

                           90       100
                   ....*....|....*....|
gi 62953120    539 KFFQLEALQRHCEIICAKSI 558
Cdd:smart00225  78 DYLQIPGLVELCEEFLLKLL 97
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 458-541 2.40e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 79.91  E-value: 2.40e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 458 MSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSK-PTNDNTCIEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNEIMELLS 536
Cdd:cd18186   1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGmKESSSSEIELDDVSPEAFEALLDYIYTG---ELELSEENVEELLA 77


                ....*
gi 62953120 537 AAKFF 541
Cdd:cd18186  78 AADKL 82
Ank_2 pfam12796
Ankyrin repeats (3 copies);
144-250 7.04e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 73.23  E-value: 7.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120   144 LMYACVRGDEAMVQMLLDAGADLNVEvvstphkypsvhpETRHWTALTFAVLHGHIPVVQLLLDAGAKvegsvehGEENY 223
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQ-------------DKNGRTALHLAAKNGHLEIVKLLLEHADV-------NLKDN 60

                          90       100
                  ....*....|....*....|....*..
gi 62953120   224 SETPLQLAAAVGNFELVSLLLERGADP 250
Cdd:pfam12796  61 GRTALHYAARSGHLEIVKLLLEKGADI 87
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
116-249 1.62e-15

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 77.69  E-value: 1.62e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 116 GRTDLVKQavsLL--GPDgINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNvevvstphkypsvHPETRHWTALTFA 193
Cdd:COG0666 164 GNLEIVKL---LLeaGAD-VNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN-------------AKDNDGKTALDLA 226

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 62953120 194 VLHGHIPVVQLLLDAGAKVEGSVEHGeenysETPLQLAAAVGNFELVSLLLERGAD 249
Cdd:COG0666 227 AENGNLEIVKLLLEAGADLNAKDKDG-----LTALLLAAAAGAALIVKLLLLALLL 277
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 453-551 3.30e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 69.20  E-value: 3.30e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 453 LNNKEMSDVTFLV--EGRPFYAHKVLLFTASPRFKALLSSKPTNDNTCIEIGYVKYP--IFQLVMQYLYYGgpeSLLIKN 528
Cdd:cd18294   9 INNPEFSDVKFLVgpERQEIFAHKCILAARCEVFRAMFLTGPQKESTQSPLVLSDIEpeVFRAVLEFIYTN---CVTLSN 85

                        90       100
                ....*....|....*....|...
gi 62953120 529 NEIMELLSAAKFFQLEALQRHCE 551
Cdd:cd18294  86 HTVIEVLAAAVEYGLDELRKLCE 108
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 451-551 1.24e-13

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 67.26  E-value: 1.24e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 451 HFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPT-NDNTCIEIGYVKYPIFQLVMQYLYYGgpESLLIKNN 529
Cdd:cd18300   2 LFLNKGLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFReSSAKEVELPGVSKETFLALLEYLYTD--QAPILEDG 79

                        90       100
                ....*....|....*....|..
gi 62953120 530 EIMELLSAAKFFQLEALQRHCE 551
Cdd:cd18300  80 DCVGLIVLANRLCLPRLVALCE 101
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 453-551 2.22e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 66.97  E-value: 2.22e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 453 LNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALL-SSKPTNDNTCIEIGYVKYPIFQLVMQYLYY---------GGPE 522
Cdd:cd18280   9 LESEEGADVTFNVDGEKFRAHKLVLAARSPVFRSMLfGPMREENEGEIVIEDVEPPVFKALLHFIYKdelpddvepAGSD 88

                        90       100
                ....*....|....*....|....*....
gi 62953120 523 SLLIKNNEIMELLSAAKFFQLEALQRHCE 551
Cdd:cd18280  89 SSSLDTTMAQHLLAAADRYALERLRLLCE 117
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 460-542 9.69e-13

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 64.11  E-value: 9.69e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 460 DVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTCIEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNEIMELLSAAK 539
Cdd:cd18315   3 DVTLACEGGSLKAHKLVLAAASPYFAALLKETPPDEHPVIILPDVPYSELKALLDFIYTG---EVNVSQEQLESLLKLAE 79


                ...
gi 62953120 540 FFQ 542
Cdd:cd18315  80 LLQ 82
Ank_2 pfam12796
Ankyrin repeats (3 copies);
116-212 5.72e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 62.06  E-value: 5.72e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120   116 GRTDLVKQAvsLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDaGADLNVEvvstphkypsvhpeTRHWTALTFAVL 195
Cdd:pfam12796   8 GNLELVKLL--LENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLK--------------DNGRTALHYAAR 70

                          90
                  ....*....|....*..
gi 62953120   196 HGHIPVVQLLLDAGAKV 212
Cdd:pfam12796  71 SGHLEIVKLLLEKGADI 87
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 454-551 8.70e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 61.89  E-value: 8.70e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 454 NNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSK-PTNDNTCIEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNEIM 532
Cdd:cd18298   8 NDPRTSDLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHwNEDDKNVIEIDQYSYPVYYAFLRYLYTD---QVDLPPEDAI 84

                        90
                ....*....|....*....
gi 62953120 533 ELLSAAKFFQLEALQRHCE 551
Cdd:cd18298  85 GLLDLANSYCEERLKKLCE 103
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 452-564 8.87e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 62.71  E-value: 8.87e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 452 FLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKAL-LSSKPTNDNTCIEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNE 530
Cdd:cd18270  20 FYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMfMSGLSESKQTHVHLRNVDAATLQIIITYAYTG---NLAINDST 96

                        90       100       110
                ....*....|....*....|....*....|....
gi 62953120 531 IMELLSAAKFFQLEALQRHCEIICAKSINTDNCV 564
Cdd:cd18270  97 VEQLYETACFLQVEDVLQRCREYLIKKINAENCV 130
BTB_POZ_RCBTB2_CHC1L cd18354
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 453-558 1.47e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349663 [Multi-domain]  Cd Length: 117  Bit Score: 61.88  E-value: 1.47e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 453 LNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSkptNDNTCIEIGYVKYPIFQLVMQYLYyggPESLLIKNNEIM 532
Cdd:cd18354  15 FDNPDTADLKFLVDGKYIYVHKVLLKIRCEHFRSLLNE---NEEEIIEMSQFSYPVYRAFLEYLY---TDSISLSPEDAI 88

                        90       100
                ....*....|....*....|....*.
gi 62953120 533 ELLSAAKFFQLEALQRHCEIICAKSI 558
Cdd:cd18354  89 GLLDLATFYRENRLKKLCQQTIKQGI 114
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 455-564 1.47e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 62.12  E-value: 1.47e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 455 NKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTC-IEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNEIME 533
Cdd:cd18237  18 QKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSeVELKDAEPDIIELLVEFAYTA---RISVNSNNVQS 94

                        90       100       110
                ....*....|....*....|....*....|.
gi 62953120 534 LLSAAKFFQLEALQRHCEIICAKSINTDNCV 564
Cdd:cd18237  95 LLDAANQYQIEPVKKMCVDFLKEQLDASNCL 125
PHA03098 PHA03098
kelch-like protein; Provisional
 457-605 2.14e-11

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 66.71  E-value: 2.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120  457 EMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTCIeigYVKYPIFQLVMQYLYYGgpeSLLIKNNEIMELLS 536
Cdd:PHA03098  10 CDESIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENEINL---NIDYDSFNEVIKYIYTG---KINITSNNVKDILS 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62953120  537 AAKFFQLEALQRHCEIICAKSINTDNCVDIYSHAKFLGVTELSAYCEGYFLKNMMVLIENEAFKQLLYD 605
Cdd:PHA03098  84 IANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKN 152
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 451-553 5.90e-11

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 59.53  E-value: 5.90e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 451 HFLNNKEMSDVTFLVEGR-PFYAHKVLLFTASPRFKALLSSKptndnTCIEI-GYVKYPIFQLVMQYLYYGgpeSLLIKN 528
Cdd:cd18299   5 NLLHSPSCADVVFILQGGvRIFAHRIVLAAASSVFADLFLMM-----TVVTLdSDITPEAFRRVLEFLYTG---VLDENE 76

                        90       100
                ....*....|....*....|....*
gi 62953120 529 NEIMELLSAAKFFQLEALQRHCEII 553
Cdd:cd18299  77 DDLKELKDAAELLELFDLVMMCTNV 101
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 453-547 1.32e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 59.17  E-value: 1.32e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 453 LNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTC-IEIGYVKYPIFQLVMQYLYYGGPESLLIKNNEI 531
Cdd:cd18287  17 FLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSeIELKDTNAEAFKALLKYIYTGRLTLTDLKEDVL 96

                        90
                ....*....|....*.
gi 62953120 532 MELLSAAKFFQLEALQ 547
Cdd:cd18287  97 LDVLGLAHQYGFEELE 112
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 453-550 1.33e-10

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 58.12  E-value: 1.33e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 453 LNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKP-TNDNTCIEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNEI 531
Cdd:cd18314   1 YNDSEFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMiESNLKEVTLEDVEPEIFETVLKYMYTG---QVTLSEENV 77

                        90
                ....*....|....*....
gi 62953120 532 MELLSAAKFFQLEALQRHC 550
Cdd:cd18314  78 LDLLMLASKYQVPDLEKLC 96
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 452-551 1.38e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 58.84  E-value: 1.38e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 452 FLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTCIEIGYVKYP----IFQLVMQYLYYGgpeSLLIK 527
Cdd:cd18292  11 LYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWWSESKQSEIELVEDPecaaVFEKFLRYLYTG---QISVN 87

                        90       100
                ....*....|....*....|....
gi 62953120 528 NNEIMELLSAAKFFQLEALQRHCE 551
Cdd:cd18292  88 LETALPLLMLADKYNVTDLKQLCV 111
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 453-566 2.16e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 59.14  E-value: 2.16e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 453 LNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSK-PTNDNTCIEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNEI 531
Cdd:cd18272  27 LEDGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNlKEARNRVIELKDVSESVFQLLVDYIYHG---TVKLRVEEL 103

                        90       100       110
                ....*....|....*....|....*....|....*
gi 62953120 532 MELLSAAKFFQLEALQRHCEIICAKSINTDNCVDI 566
Cdd:cd18272 104 QETYEVADMYQLTALFEECSRFLARTVQVRNCLQV 138
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 452-547 2.65e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 57.89  E-value: 2.65e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 452 FLNN---KEMS--DVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNtcIEIGYVKYPIFQLVMQYLYyggPESLLI 526
Cdd:cd18226  11 YLNDdrqKQSSfcDLVITVEGKEFSAHKVVVAVGSSYFHACLSKNPNTDA--VTLDHVSYSVFQHLLEFLY---TSEFFV 85

                        90       100
                ....*....|....*....|..
gi 62953120 527 KNNEIMELLSAAKFFQ-LEALQ 547
Cdd:cd18226  86 YENEIPLVLEAAKFLDiIDAVK 107
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 443-564 3.46e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 57.72  E-value: 3.46e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 443 KQTSRLdphfLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFK-ALLSSkpTNDntcIEIGYVKYPIFQLVMQYLYYGgp 521
Cdd:cd18303   7 KTVASL----FDKELYSDITIKLADKSIPAHKFVLAARSEKWSnENLAS--TNE---LDLSDISYEVVLALLRWLYTD-- 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 62953120 522 ESLLIKN-NEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCV 564
Cdd:cd18303  76 ELDLTLDdEFLLELMKAAKRFQLTDLVERCERALMSSVNVDNCI 119
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 457-564 3.49e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 55.10  E-value: 3.49e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 457 EMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSK-PTNDNTCIEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNEIMELL 535
Cdd:cd18256  19 EFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGmSESSKDVVQIHGVEPDIFHILLDFIYTG---VVEVTVSNVQELL 95

                        90       100       110
                ....*....|....*....|....*....|
gi 62953120 536 SAAKFFQL-EALQRHCEIICAKsINTDNCV 564
Cdd:cd18256  96 VAADMLQLtEVVEICCEFLKGQ-LHPSNCI 124
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 459-556 6.15e-09

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 54.18  E-value: 6.15e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 459 SDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNtCIEIGY--VKYPIFQLVMQYLYYGgpeSLLIKNNEIMELLS 536
Cdd:cd18295  20 SDVTFNVHGESFPAHRCILSARSPYFAEMFETKWKDKR-EINLKHplVNPDAFRALLQYLYTG---RLEIHVDDVEDCKR 95

                        90       100
                ....*....|....*....|
gi 62953120 537 AAKFFQLEALQRHCEIICAK 556
Cdd:cd18295  96 LAKQCRLEELIEELEAKCKK 115
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 460-566 6.69e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 54.58  E-value: 6.69e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 460 DVTFLVEGRPFYAHKVLLFTASPRFKALLSSK-PTNDNTCIEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNEIMELLSAA 538
Cdd:cd18244  32 DVTLVIEDHQFQAHKALLATQSDYFRIMFTADmRERDQDKIHLKGLTATGFSHVLQFMYYG---TIELSMLTVHEILQAA 108

                        90       100
                ....*....|....*....|....*....
gi 62953120 539 KFFQL-EALQRHCEIICAKsINTDNCVDI 566
Cdd:cd18244 109 MYVQLtEVVKFCCSFLLAK-ICLDNCAEI 136
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 461-541 1.07e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 52.28  E-value: 1.07e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 461 VTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDN-TCIEIGYVKYPIFQLVMQYLYYGGPEsllIKNNEIMELLSAAK 539
Cdd:cd01165   1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGqAEINLRDISPEDFRALLEFLYGGKRD---LDASNLLELLEAAN 77


                ..
gi 62953120 540 FF 541
Cdd:cd01165  78 FL 79
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 460-558 1.51e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 53.07  E-value: 1.51e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 460 DVTFLVEGRPFYAHKVLLFTASPRFKALL----SSKPTNDNTC--IEIGYVKYPIFQLVMQYLYYGGPEsllIKNNEIME 533
Cdd:cd18296  19 DVCFQVEGHRFPCHKAFFCGRSDYFKALLrdhfAESEENNGSIpvVTLHDVSPEVFAIVLYYIYTDDTD---LPPENAYD 95

                        90       100
                ....*....|....*....|....*
gi 62953120 534 LLSAAKFFQLEALQRHCEIICAKSI 558
Cdd:cd18296  96 VLYVADMYLLPGLKRLCGTVLAQSL 120
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 444-550 1.70e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 52.73  E-value: 1.70e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 444 QTSRLDPHFlnnkemSDVTFLVEGRPFYAHKVLLFTASPRFKALLS-SKPTNDN--TCIEIGYVKYPIFQLVMQYLYYGg 520
Cdd:cd18245   6 NSFREEPHL------CDATLVVGGEEIPVQKNVLAAASPYFRAKLNyNPPKDDGstYKIELEGISVEVMEEILDYIYTG- 78

                        90       100       110
                ....*....|....*....|....*....|..
gi 62953120 521 peslLIKNNE--IMELLSAAKFFQLEALQRHC 550
Cdd:cd18245  79 ----QIKLSEdnIQDIVQAADLLLMTDLKDLC 106
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 455-566 2.85e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 52.65  E-value: 2.85e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 455 NKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSS--KPTNDNTCiEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNEIM 532
Cdd:cd18306  15 NRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSdsDGESILTV-KLDGLDPDAVEVLVNYAYTS---RLEVPADLVK 90

                        90       100       110
                ....*....|....*....|....*....|....
gi 62953120 533 ELLSAAKFFQLEALQRHCEIICAKSINTDNCVDI 566
Cdd:cd18306  91 SVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 451-562 3.91e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 52.16  E-value: 3.91e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 451 HFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKAL----LSSKPTNDntcIEIGYVKYPIFQLVMQYLYYGGPESLli 526
Cdd:cd18345  11 LLFERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMfeheMEERKQNR---VEITDVDHEVMREMLRFIYTGKAPNL-- 85

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 62953120 527 kNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDN 562
Cdd:cd18345  86 -DKMADDLLAAADKYALERLKVMCEEALCSNLSVEN 120
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 451-562 3.93e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 52.31  E-value: 3.93e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 451 HFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSK-PTNDNTCIEIGYVKYPIFQLVMQYLYYGGPESLliknn 529
Cdd:cd18343  14 NLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEmEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNL----- 88

                        90       100       110
                ....*....|....*....|....*....|....*
gi 62953120 530 EIM--ELLSAAKFFQLEALQRHCEIICAKSINTDN 562
Cdd:cd18343  89 DKMadNLLAAADKYALERLKVMCEEALCNNLSVEN 123
Ank_4 pfam13637
Ankyrin repeats (many copies);
140-206 3.94e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.97  E-value: 3.94e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62953120   140 GMTPLMYACVRGDEAMVQMLLDAGADLNvevvstphkypsvHPETRHWTALTFAVLHGHIPVVQLLL 206
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADIN-------------AVDGNGETALHFAASNGNVEVLKLLL 54
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 452-543 4.48e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 51.56  E-value: 4.48e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 452 FLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTCIEIGyvKYP----IFQLVMQYLYygGPESLLIK 527
Cdd:cd18312   3 FRDTGEPSDITVRVGNTTFHLHKFPLCSKSGYFKRLASSSSESDPSEIELN--DFPggaeAFELVAKFCY--GMPINLTA 78

                        90
                ....*....|....*.
gi 62953120 528 NNeIMELLSAAKFFQL 543
Cdd:cd18312  79 TN-VVGLRCAAEYLEM 93
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 456-564 7.16e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 51.51  E-value: 7.16e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 456 KEMSDVTFLVEGRPFYAHKVLLFTASPRFKALL--SSKPTNDNTCIEIGY--VKYPIFQLVMQYLYYGgpeSLLIKNNEI 531
Cdd:cd18258  15 KEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIkrSSRDSGGGEKLELTMsnINADVLELLLEFVYTG---SLIIDSANA 91

                        90       100       110
                ....*....|....*....|....*....|...
gi 62953120 532 MELLSAAKFFQLEALQRHCEIICAKSINTDNCV 564
Cdd:cd18258  92 KTLLEAANKFQFHTFCKVCVSFLEKQLTASNCL 124
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 451-563 7.93e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 51.37  E-value: 7.93e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 451 HFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLsskpTNDN-----TCIEIGYVKYPIFQLVMQYLYYGgpeSLL 525
Cdd:cd18253  11 EFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMF----CNDHresreMLVEINGILAEAMDCFLQYVYTG---KVK 83

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 62953120 526 IKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDNC 563
Cdd:cd18253  84 ITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 451-562 8.21e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 51.28  E-value: 8.21e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 451 HFLNNKEMSDVTFLV----EGRPFYAHKVLLFTASPRFKALLSSKPTNDNTCIEIGYVKYPIFQLVMQYLYYG----GPE 522
Cdd:cd18281  15 FLFNNETLSDVHFIVgkgdNEQRIPAHKFVLSIGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDevqiGPE 94

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 62953120 523 SlliknneIMELLSAAKFFQLEALQRHCEIICAKSINTDN 562
Cdd:cd18281  95 T-------VMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 456-563 9.61e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 50.92  E-value: 9.61e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 456 KEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTC-IEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNEIMEL 534
Cdd:cd18250  19 RKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADrVVLHGVSAEILGLLLDFSYTG---RVTVTQDNVEAL 95

                        90       100
                ....*....|....*....|....*....
gi 62953120 535 LSAAKFFQLEALQRHCEIICAKSINTDNC 563
Cdd:cd18250  96 LRAADLFQFPSVKEACCAYLQQRLDVSNC 124
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 460-550 1.11e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 50.19  E-value: 1.11e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 460 DVTFLVEGRPFYAHKVLLFTASPRFKALLSS---KPTND-NTCIEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNEIMELL 535
Cdd:cd18307   3 DVVISVDNHSFAAHRNVLAAVSPFVKSLISSndmKATDElSITIDCDYLSPETVEQLLDYFYTG---KIVISEKNVEDLL 79

                        90
                ....*....|....*
gi 62953120 536 SAAKFFQLEALQRHC 550
Cdd:cd18307  80 KGAKYFNIPRLKDHC 94
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 455-562 1.47e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 50.72  E-value: 1.47e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 455 NKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTND-NTCIEIGYVKYPIFQLVMQYLYYGGPESLLiKNNEIME 533
Cdd:cd18344  20 NSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERlKNPIEIHDLDPQVFKEMMGFIYTGKAPHLH-SHSMACD 98

                        90       100
                ....*....|....*....|....*....
gi 62953120 534 LLSAAKFFQLEALQRHCEIICAKSINTDN 562
Cdd:cd18344  99 VLAAADKYGLEGLKVLCEDALCRNLSVEN 127
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 559-605 1.81e-07

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 48.04  E-value: 1.81e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 62953120 559 NTDNCVDIYSHAKFLGVTELSAYCEGYFLKNMMVLIENEAFKQLLYD 605
Cdd:cd14733   1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVE 47
Ank_2 pfam12796
Ankyrin repeats (3 copies);
190-287 2.03e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 48.96  E-value: 2.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120   190 LTFAVLHGHIPVVQLLLDAGAKVegsveHGEENYSETPLQLAAAVGNFELVSLLLERGAdpliGTMYRNGisTTPqgdmn 269
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADA-----NLQDKNGRTALHLAAKNGHLEIVKLLLEHAD----VNLKDNG--RTA----- 64

                          90
                  ....*....|....*...
gi 62953120   270 sFSQAAAHGHRNVFRKLL 287
Cdd:pfam12796  65 -LHYAARSGHLEIVKLLL 81
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 138-250 2.20e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 53.46  E-value: 2.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120  138 EQGMTPLMYACVRGDEAMVQMLLDAGADLNVevvstphkypsvhPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGsve 217
Cdd:PHA02875 100 KDGMTPLHLATILKKLDIMKLLIARGADPDI-------------PNTDKFSPLHLAVMMGDIKGIELLIDHKACLDI--- 163

                         90       100       110
                 ....*....|....*....|....*....|...
gi 62953120  218 hgEENYSETPLQLAAAVGNFELVSLLLERGADP 250
Cdd:PHA02875 164 --EDCCGCTPLIIAMAKGDIAICKMLLDSGANI 194
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 460-563 2.21e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 50.09  E-value: 2.21e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 460 DVTFLVEGRPFYAHKVLLFTASPRFKALLSS--KPTNDNTcIEIGYVKYPIFQLVMQYLYyggPESLLIKNNEIMELLSA 537
Cdd:cd18255  20 DVTLIADGQRFQAHKVVLASCSDYFRAMFTGgmRESSQDE-IELKGVSAKGLKHILDFAY---TSELTLDLDCIQDVLGA 95

                        90       100
                ....*....|....*....|....*.
gi 62953120 538 AKFFQLEALQRHCEIICAKSINTDNC 563
Cdd:cd18255  96 AVHLQMLPVVELCEEFLKSAMSVENC 121
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 453-562 2.25e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 49.84  E-value: 2.25e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 453 LNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSK-PTNDNTCIEIGYVKYPIFQLVMQYLYYGGPESLliknnEI 531
Cdd:cd18279  13 WENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEmEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNL-----DK 87

                        90       100       110
                ....*....|....*....|....*....|...
gi 62953120 532 M--ELLSAAKFFQLEALQRHCEIICAKSINTDN 562
Cdd:cd18279  88 MadDLLAAADKYALERLKVMCEDALCSNLSVEN 120
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 460-551 3.39e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 49.05  E-value: 3.39e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 460 DVTFLVEGRPFYAHKVLLFTASPRFKALLS--SKPTNDNTCIEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNEIMELLSA 537
Cdd:cd18329  23 DCSILVEGQVFKAHRNVLFASSGYFKMLLSqnAKETGQPTVATFDVFSPDTFTIILDFVYSG---KLSLTSQNVIEVMSA 99

                        90
                ....*....|....
gi 62953120 538 AKFFQLEALQRHCE 551
Cdd:cd18329 100 ASYLQMTDVISVCK 113
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 452-546 3.85e-07

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 49.18  E-value: 3.85e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 452 FLNNKEMsDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTC-IEIGYVKYPIFQLVMQYLYygGPESLLIKNNE 530
Cdd:cd18286  12 FLNGEDS-DITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSeITLTGVSHAAVSFVLLFIY--GGVLDLPDDVN 88

                        90
                ....*....|....*.
gi 62953120 531 IMELLSAAKFFQLEAL 546
Cdd:cd18286  89 LGELLSLADMYGLDGL 104
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 457-550 4.25e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 49.07  E-value: 4.25e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 457 EMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPT-NDNTCIEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNEIMELL 535
Cdd:cd18257  17 ELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSeKENSEVEFQCIDETALQAIVEYAYTG---TVFISQATVESLL 93

                        90
                ....*....|....*
gi 62953120 536 SAAKFFQLEALQRHC 550
Cdd:cd18257  94 PAANLLQIKLVLKEC 108
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 460-543 5.09e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 48.57  E-value: 5.09e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 460 DVTFLVEGRPFYAHKVLLFTASPRFKALLS--SKPTNDNTCIEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNEIMELLSA 537
Cdd:cd18199  20 DCSIIVEGRIFKAHRNVLFASSGYFRMLLShyIQDTGRPSTASFDVFSSDAFSIILDFVYSG---KLSLTSQNVIEVMSA 96


                ....*.
gi 62953120 538 AKFFQL 543
Cdd:cd18199  97 ASYLQM 102
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 455-563 6.95e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 48.48  E-value: 6.95e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 455 NKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTN-DNTCIEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNEIME 533
Cdd:cd18240  14 EGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNEtEKKVYKIPGVSPEMMELIIEYAYTR---TVPITAENVEE 90

                        90       100       110
                ....*....|....*....|....*....|
gi 62953120 534 LLSAAKFFQLEALQRHCEIICAKSINTDNC 563
Cdd:cd18240  91 LLPAADQFNIMGIVKACCDFLEDQLCPENC 120
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 460-551 7.79e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 48.00  E-value: 7.79e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 460 DVTFLVEGRPFYAHKVLLFTASPRFKALLSS--KPTNDNTCIEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNEIMELLSA 537
Cdd:cd18330  20 DCSIIVEGRIFKAHRNILFANSGYFRALLIHyiQDSGRHSTASLDIVTSEAFSIILDFLYSG---KLDLCSENVIEVMSA 96

                        90
                ....*....|....
gi 62953120 538 AKFFQLEALQRHCE 551
Cdd:cd18330  97 ASYLQMTDVVNFCK 110
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 454-550 8.07e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 48.39  E-value: 8.07e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 454 NNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTCI-EIGYVKYPIFQLVMQYLYYGgpeSLLIKNNEIM 532
Cdd:cd18326  21 TQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVyEIDFVSAEALTALLDFAYTA---TLTVSTSNVG 97

                        90
                ....*....|....*...
gi 62953120 533 ELLSAAKFFQLEALQRHC 550
Cdd:cd18326  98 DILSAARLLEIPAVSHVC 115
PHA03095 PHA03095
ankyrin-like protein; Provisional
 117-250 8.43e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 51.95  E-value: 8.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120  117 RTDLVKQAVSLL---GPDgINTMSEQGMTPL-MYACVRGDEAMVQMLLDAGADLNVEVVS--TP-HKY---PSVHPetrh 186
Cdd:PHA03095  58 SSEKVKDIVRLLleaGAD-VNAPERCGFTPLhLYLYNATTLDVIKLLIKAGADVNAKDKVgrTPlHVYlsgFNINP---- 132

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62953120  187 wtaltfavlhghiPVVQLLLDAGAKVEGSvehgeENYSETPlqLAAAVG----NFELVSLLLERGADP 250
Cdd:PHA03095 133 -------------KVIRLLLRKGADVNAL-----DLYGMTP--LAVLLKsrnaNVELLRLLIDAGADV 180
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 458-553 1.19e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 47.73  E-value: 1.19e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 458 MSDVTFLVEGRPFYAHKVLLFTASPRFKALLSskpTNDNTCIEIGYVKYP-IFQLVMQYLYYGgpeSLLIKNNEIMELLS 536
Cdd:cd18222  25 LCDIVVNVQGQSFRAHKVVLAASSPYFRDHMS---LNEMSTVSISVIKNPtVFEQLLSFCYTG---RICLQLADIISYLT 98

                        90
                ....*....|....*..
gi 62953120 537 AAKFFQLEALQRHCEII 553
Cdd:cd18222  99 AASFLQMQHIIDKCTQI 115
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 451-564 1.35e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 47.67  E-value: 1.35e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 451 HFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTND-NTCIEIGYVKYPIFQLVMQYLYYGgpeSLLIKNN 529
Cdd:cd18238   8 QFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESkQDSITIKDIDEEAVELLVDFAYTG---KLTLTVD 84

                        90       100       110
                ....*....|....*....|....*....|....*
gi 62953120 530 EIMELLSAAKFFQLEALQRHCEIICAKSINTDNCV 564
Cdd:cd18238  85 NVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCL 119
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 453-550 1.37e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 47.39  E-value: 1.37e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 453 LNNKEMSDVTFLVeGRP-----FYAHKVLLFTASPRFKALLSSKPTNDNTCIEIGYVKYPIFQLVMQYLYYggpESLLIK 527
Cdd:cd18282   2 FNNELMADVHFIV-GPPggtqrIPAHKYVLATGSSVFYAMFYGGLAENKNEIEIPDVEPAAFLNLLRYLYC---DEIDLE 77

                        90       100
                ....*....|....*....|...
gi 62953120 528 NNEIMELLSAAKFFQLEALQRHC 550
Cdd:cd18282  78 PDTVLATLYAAKKYLVPHLARAC 100
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 139-168 1.37e-06

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 44.89  E-value: 1.37e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 62953120    139 QGMTPLMYACVRGDEAMVQMLLDAGADLNV 168
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 460-563 1.41e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 47.82  E-value: 1.41e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 460 DVTFLVEGRPFYAHKVLLFTASPRFKALLSSK-PTNDNTCIEIGYVKYPIFQLVMQYLYyggPESLLIKNNEIMELLSAA 538
Cdd:cd18242  23 DVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEmSEKGKSEVELQGLTASTMEILLDFVY---TETVHVTVENVQELLPAA 99

                        90       100
                ....*....|....*....|....*
gi 62953120 539 KFFQLEALQRHCEIICAKSINTDNC 563
Cdd:cd18242 100 CLLQLKGVKQACCEFLESQLDPSNC 124
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 133-261 2.43e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 50.35  E-value: 2.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120  133 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTphKYPsVHPETRhwtaltfavlHGHIPVVQLLLDAGAKV 212
Cdd:PHA02874 117 VNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNG--CYP-IHIAIK----------HNFFDIIKLLLEKGAYA 183

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 62953120  213 egsveHGEENYSETPLQLAAAVGNFELVSLLLERGADplIGTMYRNGIS 261
Cdd:PHA02874 184 -----NVKDNNGESPLHNAAEYGDYACIKLLIDHGNH--IMNKCKNGFT 225
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 457-550 2.53e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 46.57  E-value: 2.53e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 457 EMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTCIEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNEIMELLS 536
Cdd:cd18204  17 EFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSVIEIDFLRSDIFEEVLNYMYTA---KISVKKEDVNLMMS 93

                        90
                ....*....|....
gi 62953120 537 AAKFFQLEALQRHC 550
Cdd:cd18204  94 SGQILGIRFLDKLC 107
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 435-550 2.73e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 46.50  E-value: 2.73e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 435 PKLTEIKRKqtsrldphflnnKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLsskpTND-----NTCIEIGYVKYPIF 509
Cdd:cd18247   8 PVMEEIRRQ------------GKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMF----THDmveskQDEITMQGIEPSAL 71

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 62953120 510 QLVMQYLYYGgpeSLLIKNNEIMELLSAAKFFQLEALQRHC 550
Cdd:cd18247  72 EALINFAYSG---RIAIDTSNVQSLLVGASFLQLQSVKDAC 109
Ank_2 pfam12796
Ankyrin repeats (3 copies);
116-168 2.89e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.88  E-value: 2.89e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 62953120   116 GRTDLVKQAVSLLGPDgintMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNV 168
Cdd:pfam12796  41 GHLEIVKLLLEHADVN----LKDNGRTALHYAARSGHLEIVKLLLEKGADINV 89
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 89-250 2.91e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 50.40  E-value: 2.91e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120  89 FCASRKLDAVAIEakfkqdlgfRMLNCGRTDLVKQAVsllgpdgintmseQGMTPLMYACVRGDEAMVQMLLDAGADL-N 167
Cdd:cd22192  22 LLAAKENDVQAIK---------KLLKCPSCDLFQRGA-------------LGETALHVAALYDNLEAAVVLMEAAPELvN 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 168 VEVVSTPHKYPsvhpetrhwTALTFAVLHGHIPVVQLLLDAGAKVE-----GSV----EHGEENYSETPLQLAAAVGNFE 238
Cdd:cd22192  80 EPMTSDLYQGE---------TALHIAVVNQNLNLVRELIARGADVVspratGTFfrpgPKNLIYYGEHPLSFAACVGNEE 150

                       170
                ....*....|..
gi 62953120 239 LVSLLLERGADP 250
Cdd:cd22192 151 IVRLLIEHGADI 162
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 142-263 4.18e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 49.60  E-value: 4.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120  142 TPLMYACVRGDEAMVQMLLDAGADLNVEvvstphkypsvhpETRHWTALTFAVLHGHIPVVQLLLDAGAkvegSVEHGEE 221
Cdd:PHA02875 137 SPLHLAVMMGDIKGIELLIDHKACLDIE-------------DCCGCTPLIIAMAKGDIAICKMLLDSGA----NIDYFGK 199

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 62953120  222 NYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGISTT 263
Cdd:PHA02875 200 NGCVAALCYAIENNKIDIVRLFIKRGADCNIMFMIEGEECTI 241
Ank_4 pfam13637
Ankyrin repeats (many copies);
186-244 4.28e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.19  E-value: 4.28e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 62953120   186 HWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGeenysETPLQLAAAVGNFELVSLLL 244
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNG-----ETALHFAASNGNVEVLKLLL 54
BTB_POZ_RCBTB1_CLLD7 cd18353
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 453-553 4.32e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349662 [Multi-domain]  Cd Length: 117  Bit Score: 46.09  E-value: 4.32e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 453 LNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNT-CIEIGYVKYPIFQLVMQYLYyggPESLLIKNNEI 531
Cdd:cd18353  15 FDSPETSDLKFRVDGKYIHVHKAVLKIRCEHFRTMFQSHWNEDMKeVIEIDQFSYPVYRAFLEYLY---TDSVDLPPEDA 91

                        90       100
                ....*....|....*....|..
gi 62953120 532 MELLSAAKFFQLEALQRHCEII 553
Cdd:cd18353  92 IGLLDLATSYCENRLKKLCQHI 113
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 458-550 5.48e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 46.21  E-value: 5.48e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 458 MSDVTFLVEGRPFYAHKVLLFTASPRFKALLSS--KPTNDNTCIEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNEIMELL 535
Cdd:cd18230  21 LCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQvqKTSDQATVTHLDIVTAQGFKAIIDFMYSA---HLALTSKNVIEVM 97

                        90
                ....*....|....*
gi 62953120 536 SAAKFFQLEALQRHC 550
Cdd:cd18230  98 SAASYLQMTDIVQAC 112
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 456-564 7.44e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 45.61  E-value: 7.44e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 456 KEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSS--KPTNDNTcIEIGYVKYPIFQLVMQYLYyggPESLLIKNNEIME 533
Cdd:cd18236  22 NSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNdlKEKYEEK-IIIKGVDAETMQILLDYTY---TSKVLITKQNVQR 97

                        90       100       110
                ....*....|....*....|....*....|.
gi 62953120 534 LLSAAKFFQLEALQRHCEIICAKSINTDNCV 564
Cdd:cd18236  98 VLEAASLFQFLRMVDACASFLTEALHPENCV 128
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 459-549 8.12e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 46.15  E-value: 8.12e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 459 SDVTFLVE-GRPFYAHKVLLFTASPRFKALLSSKP-TNDNT--------CIEIGYVKYPIFQLVMQYLYYGGPESLLIKN 528
Cdd:cd18310  19 SDAEIIVEgGRPVPVHRCILAARSPFFRDIFASAKaEGANTkpklelreLIPGGIVGYDAFMLVLSYLYSGRLRLVPKEG 98

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 62953120 529 NEIM-----------------ELLSAAKFFQLEAL----QRH 549
Cdd:cd18310  99 SACVdsdcwhvacrpavdfalEVLYAASVFQIPELvslfQRR 140
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 452-562 9.30e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 45.43  E-value: 9.30e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 452 FLNNKEMSDVTFLV-EGRPFY---------AHKVLLFTASPRFKALLSSKPTNDNTCIEIGYVKYPIFQLVMQYLYYG-- 519
Cdd:cd18346  16 LFNNELLSDVRFVVgKGRPRGpgpgaqripAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDev 95

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 62953120 520 --GPESlliknneIMELLSAAKFFQLEALQRHCEIICAKSINTDN 562
Cdd:cd18346  96 qiGPET-------VMTTLYTAKKYAVPALEAHCVEFLTKHLRADN 133
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 139-168 1.03e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 42.66  E-value: 1.03e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 62953120   139 QGMTPLMYACVR-GDEAMVQMLLDAGADLNV 168
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNA 31
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 456-550 1.16e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 45.07  E-value: 1.16e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 456 KEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTC-IEIGYV--KYPIFQLVMQYLYYGG----PESLLIkn 528
Cdd:cd18309  18 GDFCDITLLLDGHPIPAHKAILAARCSYFEAMFRSFMPEDNTVnISIGEMvpSRQAFDSLLRYIYYGDvtmpPEDSLY-- 95

                        90       100
                ....*....|....*....|....
gi 62953120 529 neimeLLSAAKFFQL--EALQRHC 550
Cdd:cd18309  96 -----LFSAPYFYGFtnNRLQAYC 114
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 458-559 1.33e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 44.95  E-value: 1.33e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 458 MSDVTFLVEGRPFYAHKVLLFTASPRFKALL---SSKPTNDNTCIEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNEIMEL 534
Cdd:cd18201  21 LCDVNIVVSGKVFRAHKNILVAGSRFFKTLYcftNKESCDQTTVTHLDVVAVQGFSVILDFMYSG---NLVLTSQNAIEV 97

                        90       100
                ....*....|....*....|....*
gi 62953120 535 LSAAKFFQLEALQRHCEIICAKSIN 559
Cdd:cd18201  98 MSVASYLQMTEVVQSCRNFIKDALN 122
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 459-564 1.37e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 44.76  E-value: 1.37e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 459 SDVTFLVEGRPFYAHKVLLFTASPRFKALL-SSKPTNDNTCIEIGYVKYPIFQLVMQYLYYGGpesLLIKNNEIMELLSA 537
Cdd:cd18265  24 TDVVLLVDGKDFPCHRATLSANSAYFRAMFgGHLKESRQAVVEIQKVSAAAMEVLLDYMYGGG---LRIQEDNVESVLEA 100

                        90       100
                ....*....|....*....|....*..
gi 62953120 538 AKFFQLEALQRHCEIICAKSINTDNCV 564
Cdd:cd18265 101 SDLLQVSKLREACVRFLEGQLHPCNCL 127
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 149-251 1.43e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 48.15  E-value: 1.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120   149 VRGDEAMVQMLLDAGAdlnvEVVSTPHKY-PSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGS------VEHGEE 221
Cdd:TIGR00870  94 VDAVEAILLHLLAAFR----KSGPLELANdQYTSEFTPGITALHLAAHRQNYEIVKLLLERGASVPARacgdffVKSQGV 169

                          90       100       110
                  ....*....|....*....|....*....|...
gi 62953120   222 N---YSETPLQLAAAVGNFELVSLLLERGADPL 251
Cdd:TIGR00870 170 DsfyHGESPLNAAACLGSPSIVALLSEDPADIL 202
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 451-564 1.56e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 44.82  E-value: 1.56e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 451 HFLNNKEMSDVTFL-VEGRPFYAHKVLLFTASPRFKALLSSK-PTNDNTCIEIGYVKYPIFQLVMQYLYyggPESLLIKN 528
Cdd:cd18252  14 TFYLDGLFTDITLQcASGQIFHCHKAALAACSSYFKVMFTADmKEKSNNVIKLSGIDHDILEALVNYVY---TSQICITE 90

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 62953120 529 NEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCV 564
Cdd:cd18252  91 RNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCL 126
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 455-562 1.57e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 44.71  E-value: 1.57e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 455 NKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSK-PTNDNTCIEIGYVKYPIFQLVMQYLYYGGPESLlikNNEIME 533
Cdd:cd18342  19 NSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEmEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNL---DKMADD 95

                        90       100
                ....*....|....*....|....*....
gi 62953120 534 LLSAAKFFQLEALQRHCEIICAKSINTDN 562
Cdd:cd18342  96 LLAAADKYALERLKVMCEDALCSNLSVEN 124
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 457-566 2.17e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 44.59  E-value: 2.17e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 457 EMSDVTFLVE-GRPFYAHKVLLFTASPRFKALLSSKPTNDNTC-IEIGYVKYPIFQLVMQYLYyggPESLLIKNNEIMEL 534
Cdd:cd18274  21 QLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKeVRIVGVEAESMHLVLDYAY---TSRVTLTEANVQAL 97

                        90       100       110
                ....*....|....*....|....*....|..
gi 62953120 535 LSAAKFFQLEALQRHCEIICAKSINTDNCVDI 566
Cdd:cd18274  98 FTAASIFQIPSLQDQCAQFMISRLDPQNSIGV 129
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 444-550 2.36e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 43.77  E-value: 2.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 444 QTSRLDPhflnNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSskPTNDNTCIEIGYVKYPIFQLVMQYLYyggPES 523
Cdd:cd18218   8 LAARLRP----AGALCDTLITVGSQEFPAHSLVLAGASQQLGRQLT--NPNPGQWCLGEGISPSTFKQLLDFVY---GES 78

                        90       100
                ....*....|....*....|....*..
gi 62953120 524 LLIKNNEIMELLSAAKFFQLEALQRHC 550
Cdd:cd18218  79 VEVQPGELRPLLEAARALEVESLEEAC 105
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 457-566 2.39e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 44.41  E-value: 2.39e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 457 EMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTN-DNTCIEIGYVKYPIFQLVMQYLYyggPESLLIKNNEIMELL 535
Cdd:cd18276  20 ELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGLMEcSQREVVLHDITAESVSIILNYMY---SSDLHLTNSNVQGVA 96

                        90       100       110
                ....*....|....*....|....*....|.
gi 62953120 536 SAAKFFQLEALQRHCEIICAKSINTDNCVDI 566
Cdd:cd18276  97 TAAFFLQMEDIFSVCQKYMMDHMDASNCLGI 127
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 452-562 3.18e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 43.91  E-value: 3.18e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 452 FLNNKEMSDVTFLV----EGRPFYAHKVLLFTASPRFKALLSSKPTNDNTCIEIGYVKYPIFQLVMQYLYyggPESLLIK 527
Cdd:cd18347  16 LFNNEVLSDVHFLVgkglGSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLALLKFLY---SDEVQIG 92

                        90       100       110
                ....*....|....*....|....*....|....*
gi 62953120 528 NNEIMELLSAAKFFQLEALQRHCEIICAKSINTDN 562
Cdd:cd18347  93 PETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 127
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 458-564 3.39e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 43.12  E-value: 3.39e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 458 MSDVTFLVEGRPFYAHKVLLFTASPRFKALLsskpTND-----NTCIEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNEIM 532
Cdd:cd18234   1 LCDVILIAGDRRIPAHRLVLSAVSDYFAAMF----TNDvreatEEEIKLKDVDPDALWTLVQYCYTG---RLELKEDNVE 73

                        90       100       110
                ....*....|....*....|....*....|..
gi 62953120 533 ELLSAAKFFQLEALQRHCEIICAKSINTDNCV 564
Cdd:cd18234  74 SLLATACLLQLSEVVEACCGFLMKQLHPSNCL 105
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 140-250 3.60e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 46.52  E-value: 3.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120  140 GMTPLMYACVRGDEAMVQMLLDAGADLNVevvstphKYPSVHPEtrhwtaLTFAVLHGHIPVVQLLLDAGaKVEGSVEHG 219
Cdd:PHA02875  35 GISPIKLAMKFRDSEAIKLLMKHGAIPDV-------KYPDIESE------LHDAVEEGDVKAVEELLDLG-KFADDVFYK 100

                         90       100       110
                 ....*....|....*....|....*....|.
gi 62953120  220 EENyseTPLQLAAAVGNFELVSLLLERGADP 250
Cdd:PHA02875 101 DGM---TPLHLATILKKLDIMKLLIARGADP 128
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 460-517 4.15e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 42.66  E-value: 4.15e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62953120 460 DVTFLVEGRPFYAHKVLLFTASPRF-KALLSSKPT----NDNTCIEIGYVKYPIFQLVMQYLY 517
Cdd:cd18301  20 DVVFQVGGKTFPAHKFILASRSDYFrKLFLSSLLTsedaVGCDVVHIEKVPPEIFEQLLQFIY 82
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 460-550 4.51e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 43.31  E-value: 4.51e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 460 DVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTC--------IEIGYVKYPIFQLVMQYLYyggPESLLIKNNEI 531
Cdd:cd18228  21 DVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLVLvspagkcvLDLHHVTVTGFAPLLEYAY---TSTLSINTENI 97

                        90
                ....*....|....*....
gi 62953120 532 MELLSAAKFFQLEALQRHC 550
Cdd:cd18228  98 IDVLAAASYMQMFNVANTC 116
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 453-550 5.63e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 42.66  E-value: 5.63e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 453 LNNKEMSDVTFLV----EGRPFYAHKVLLFTASPRFKALLSSKPTNDNTCIEIGYVKYPIFQLVMQYLYyggPESLLIKN 528
Cdd:cd18349   3 FNNELMADVHFIVgppgASQRVPAHKYVLAVGSSVFYAMFYGDLAEVKSEIHIPDVEPAAFLILLKYMY---SDEIDLEA 79

                        90       100
                ....*....|....*....|..
gi 62953120 529 NEIMELLSAAKFFQLEALQRHC 550
Cdd:cd18349  80 DTVLATLYAAKKYIVPALAKAC 101
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 140-168 5.77e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 40.32  E-value: 5.77e-05
                          10        20
                  ....*....|....*....|....*....
gi 62953120   140 GMTPLMYACVRGDEAMVQMLLDAGADLNV 168
Cdd:pfam13606   2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 457-553 5.84e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 43.09  E-value: 5.84e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 457 EMSDVTFLVEGRPFYAHKVLLFTASPRFKallSSKPTNDNTCIEIGYVKYP-IFQLVMQYLYYGgpeSLLIKNNEIMELL 535
Cdd:cd18220  24 KLCDIIVHIQGQPFRAHKAVLAASSPYFR---DHSALSTMSGLSISVIKNPnVFEQLLSFCYTG---RMSLQLKDVVSFL 97

                        90
                ....*....|....*...
gi 62953120 536 SAAKFFQLEALQRHCEII 553
Cdd:cd18220  98 TAASFLQMQCVIDKCTQI 115
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 121-256 7.20e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 45.43  E-value: 7.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120  121 VKQAVSLLGPDG--INTMSEQGMTPLMYACVR--GDEAMVQMLLDAGADLNVevvSTPHKYPSVHPETRhwtaltfaVLH 196
Cdd:PHA03100  85 VKEIVKLLLEYGanVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNI---KNSDGENLLHLYLE--------SNK 153

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62953120  197 GHIPVVQLLLDAGAKVEG--SVE----HG-----EENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMY 256
Cdd:PHA03100 154 IDLKILKLLIDKGVDINAknRVNyllsYGvpiniKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKY 224
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 452-567 8.90e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 42.89  E-value: 8.90e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 452 FLNNKEMSDVTFLVE--------GRPFYAHKVLLFTASPRFKALLS-----SKPTNdntcIEIGYVKYPIFQLVMQYLYY 518
Cdd:cd18273  20 FYDARLLTDVTIEVNgpgsgpgsGRLFPCNRNVLAAASPYFKSMFTgglyeSKQET----VTIHDVDSESMALIIDYCYT 95

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 62953120 519 GgpeSLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCVDIY 567
Cdd:cd18273  96 G---RVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGIL 141
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 455-550 9.71e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 42.37  E-value: 9.71e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 455 NKEMSDVTFLVEGRP----FYAHKVLLFTASPRFKALLSS--KPTNDNTcIEIGYVKYPIFQLVMQYLYYGgpeSLLIKN 528
Cdd:cd18248  18 SQQLCDVTLKVKYQDpkeeFMAHKVVLASSSPYFKAMFTSglRECGMEV-VPIEGVHPCVMSRLIEFAYTA---SISVGE 93

                        90       100
                ....*....|....*....|..
gi 62953120 529 NEIMELLSAAKFFQLEALQRHC 550
Cdd:cd18248  94 KCVLHVLPGAVMYQMDSVVKAC 115
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 451-565 1.16e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 42.11  E-value: 1.16e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 451 HFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNtcIEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNE 530
Cdd:cd18260  11 RMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILKKDPSLQR--VELNDISPLGLATVITYAYTG---KLTLSLYT 85

                        90       100       110
                ....*....|....*....|....*....|....*
gi 62953120 531 IMELLSAAKFFQLEALQRHCEIICAKSINTDNCVD 565
Cdd:cd18260  86 IGSTISAASYLQIHALVKMCCDFLMQEMNVENCMY 120
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 139-249 1.22e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 44.87  E-value: 1.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120  139 QGMTPLMYACVRGDEAMVQMLLDAGAdlNVEVVSTPHKYPSVHpetrhwtaltfAVLHGHIPVVQLLLDAGAkvegSVEH 218
Cdd:PHA02878 167 KGNTALHYATENKDQRLTELLLSYGA--NVNIPDKTNNSPLHH-----------AVKHYNKPIVHILLENGA----STDA 229

                         90       100       110
                 ....*....|....*....|....*....|..
gi 62953120  219 gEENYSETPLQLAAA-VGNFELVSLLLERGAD 249
Cdd:PHA02878 230 -RDKCGNTPLHISVGyCKDYDILKLLLEHGVD 260
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 453-550 1.51e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 41.75  E-value: 1.51e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 453 LNNKE----MSDVTFLVEGRPFYAHKVLLFTASPRFKALLSskpTNDNTCIEIGYVKYPIFQLVMQYLYYGGPESLLIKN 528
Cdd:cd18216  11 LNNQRtkgfLCDVIIVVENSLFRAHKNVLAASSGYFKSLVL---HDNLIHLDQDMVSPTVFQQILDFIYTGKLLDSLFEE 87

                        90       100
                ....*....|....*....|..
gi 62953120 529 NEIMELLSAAKFFQLEALQRHC 550
Cdd:cd18216  88 PNLSEVLAAANYLQLPDLAALC 109
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 455-564 1.87e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 41.67  E-value: 1.87e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 455 NKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSK-PTNDNTCIEIGYVKYPIFQLVMQYLYyggPESLLIKNNEIME 533
Cdd:cd18249  20 HRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGElAESRQTEVTIRDIDERAMELLIDFAY---TSQITVEEGNVQT 96

                        90       100       110
                ....*....|....*....|....*....|.
gi 62953120 534 LLSAAKFFQLEALQRHCEIICAKSINTDNCV 564
Cdd:cd18249  97 LLPAACLLQLAEIQEVCCEFLKRQLDPSNCL 127
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 458-551 2.00e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 41.74  E-value: 2.00e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 458 MSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKP-TNDNTCIEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNEIMELLS 536
Cdd:cd18323  23 LCDCTVLVGSTQFLAHRAVLASCSPFFHMFYKEQLdKRDLVCINNEIVTAPAFSLLLEFMYEG---RLSFNDTPVEDVLA 99

                        90
                ....*....|....*
gi 62953120 537 AAKFFQLEALQRHCE 551
Cdd:cd18323 100 AASYLHMNDIVKVCK 114
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 140-210 2.26e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 44.21  E-value: 2.26e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62953120  140 GMTPLMYACVRGDEAMVQMLLDAGADLNvevvstphkYPSVHPETrhwTALTFAVLHGHIPVVQLLLDAGA 210
Cdd:PHA02875 168 GCTPLIIAMAKGDIAICKMLLDSGANID---------YFGKNGCV---AALCYAIENNKIDIVRLFIKRGA 226
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 460-544 2.29e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 41.55  E-value: 2.29e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 460 DVTFLVEGRPFYAHKVLLFTASPRFKALLSSkptNDNTCIEI-GYVKYPIFQLVMQYLYYGgpeSLLIKNNEIMELLSAA 538
Cdd:cd18289  31 DVSIVVKGQAFKAHRAVLAASSLYFRDLFSG---NSKSAFELpATVPPACFQQILSFCYTG---KLTMAASEQLVVMYTA 104


                ....*.
gi 62953120 539 KFFQLE 544
Cdd:cd18289 105 GFLQIQ 110
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 459-519 2.90e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 40.01  E-value: 2.90e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62953120 459 SDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKP-TNDNTCIEIGY--VKYPIFQLVMQYLYYG 519
Cdd:cd18283   3 TDVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPgYGAEIPVDLPTagIDVPMFSALLRYLYTG 66
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 142-249 3.93e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 43.51  E-value: 3.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120  142 TPLMYACVRGDEAMVQMLLDAGADlnVEVVStphkypsvhpeTRHWTALTFAvLHGHIPV--VQLLLDAGAKVegsveHG 219
Cdd:PHA02876 377 TPIHYAAVRNNVVIINTLLDYGAD--IEALS-----------QKIGTALHFA-LCGTNPYmsVKTLIDRGANV-----NS 437

                         90       100       110
                 ....*....|....*....|....*....|.
gi 62953120  220 EENYSETPLQLAAAVG-NFELVSLLLERGAD 249
Cdd:PHA02876 438 KNKDLSTPLHYACKKNcKLDVIEMLLDNGAD 468
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 460-517 3.93e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 40.20  E-value: 3.93e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 62953120 460 DVTFLVEGRPFYAHKVLLFTASPRFKALLSSKptndNTCIEIGYVKYPIFQLVMQYLY 517
Cdd:cd18219  23 DVTVIVEDRKFRAHKNILSASSTYFHQLFSVA----GQVVELNFIRADIFAEILNYIY 76
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 141-249 6.21e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 42.73  E-value: 6.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120  141 MTPLMYACVRGDEAMVQMLLDAGADLNVEVV--STPHkypsvhpetrHWTALTFAVLHGHIPVVQLLLDAGAKVEGSveh 218
Cdd:PHA03100  36 VLPLYLAKEARNIDVVKILLDNGADINSSTKnnSTPL----------HYLSNIKYNLTDVKEIVKLLLEYGANVNAP--- 102

                         90       100       110
                 ....*....|....*....|....*....|...
gi 62953120  219 geENYSETPLQLAAA--VGNFELVSLLLERGAD 249
Cdd:PHA03100 103 --DNNGITPLLYAISkkSNSYSIVEYLLDNGAN 133
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 133-248 6.21e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 42.64  E-value: 6.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120  133 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKY---------------------------PSVHPET- 184
Cdd:PHA02874  28 INISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLltaikigahdiikllidngvdtsilpiPCIEKDMi 107

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62953120  185 ---------------RHWTALTFAVLHGHIPVVQLLLDAGAKVegSVEHGEENYsetPLQLAAAVGNFELVSLLLERGA 248
Cdd:PHA02874 108 ktildcgidvnikdaELKTFLHYAIKKGDLESIKMLFEYGADV--NIEDDNGCY---PIHIAIKHNFFDIIKLLLEKGA 181
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 458-550 6.37e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 39.93  E-value: 6.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 458 MSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTCIEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNEIMELLSA 537
Cdd:cd18278  31 LCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQTENDLVVSLPEEVTARGFGPLLQFAYTA---KLLLSRENIQEVIRC 107

                        90
                ....*....|...
gi 62953120 538 AKFFQLEALQRHC 550
Cdd:cd18278 108 AEFLRMHNLEDSC 120
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 452-551 6.48e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 39.96  E-value: 6.48e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 452 FLNNkEMSDVTFLVEGRPFYAHKVLLfTASPRFKALLSS--KPTNDNTcIEIGYVKYPI----FQLVMQYLYYggpESLL 525
Cdd:cd18305  10 FLNG-ENSDITICALGREWKLHKIYL-CQSGYFASMFSGswKESKETV-INLEIPDDNItveaLNVVFGSLYR---DEIE 83

                        90       100
                ....*....|....*....|....*.
gi 62953120 526 IKNNEIMELLSAAKFFQLEALQRHCE 551
Cdd:cd18305  84 IKPSRVVSILAAATLLQLDGLIQQCS 109
PHA02713 PHA02713
hypothetical protein; Provisional
 452-605 6.65e-04

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 42.69  E-value: 6.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120  452 FLNNKEMSDVTFLV-EGRPFYAHKVLLFTASPRFKALLSSKPTNDN--TCIEIGYVKYPIFQLVMQYLYyggpeSLLIKN 528
Cdd:PHA02713  19 LLDDDILCDVIITIgDGEEIKAHKTILAAGSKYFRTLFTTPMIIRDlvTRVNLQMFDKDAVKNIVQYLY-----NRHISS 93

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62953120  529 NEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCVDIYSHAKFLGVTELSAYCEGYFLKNMMVLIENEAFKQLLYD 605
Cdd:PHA02713  94 MNVIDVLKCADYLLIDDLVTDCESYIKDYTNHDTCIYMYHRLYEMSHIPIVKYIKRMLMSNIPTLITTDAFKKTVFE 170
BTB2_POZ_RHOBTB3 cd18360
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 452-556 8.83e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349669 [Multi-domain]  Cd Length: 110  Bit Score: 39.45  E-value: 8.83e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 452 FLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTC-IEIGYVKYPIFQLVMQYLYYGG--PESLLikn 528
Cdd:cd18360   4 FFNSPLLADVVFKIQGTTVPAHRAVLVARCEVMAAMFNGNYAEAKSFlVPIYGVSKDTFLSFLEYLYTDSccPASIL--- 80

                        90       100
                ....*....|....*....|....*....
gi 62953120 529 nEIMELLSAAKFFQLEALQRHCEI-ICAK 556
Cdd:cd18360  81 -QAMALLICAEMYQVSRLQHICELyIITQ 108
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 458-550 9.08e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 39.57  E-value: 9.08e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 458 MSDVTFLVEGRPFYAHKVLLFTASPRFKALLsskpTNDNTC-IEIGYVKYPIFQLVMQYLYYGGpeslLIKNNEIME--- 533
Cdd:cd18334  21 LCDVIIVVENALFRAHKNILAASSMYFKSLV----LHDNLInLDTDMVNPTVFRQILDFIYTGK----LLTSDQPGEqnf 92

                        90
                ....*....|....*....
gi 62953120 534 --LLSAAKFFQLEALQRHC 550
Cdd:cd18334  93 naLLTAASYLQLHDLAALC 111
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 443-566 9.09e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 39.64  E-value: 9.09e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 443 KQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLsskpTND-----NTCIEIGYVKYPIFQLVMQYLY 517
Cdd:cd18336   4 EQTFRKMENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMF----TNDvreakQEEIKMEGVDPDALKALVHYAY 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 62953120 518 YGgpeSLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCVDI 566
Cdd:cd18336  80 TG---VLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGI 125
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 460-550 9.33e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 39.39  E-value: 9.33e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 460 DVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNT--CIEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNEIMELLSA 537
Cdd:cd18293  17 DVLLQAEGESVPAHCCVLSACSPYLTERLSSEPPPAGQkvVLELQGLKAHTLLKLVDFLYTS---ELEVSSEEAQDVLAA 93

                        90
                ....*....|...
gi 62953120 538 AKFFQLEALQRHC 550
Cdd:cd18293  94 ARRLQISELESLC 106
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 188-250 1.12e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 42.17  E-value: 1.12e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62953120 188 TALTFAVLHGHIPVVQLLLDAGAKVEGSV--------EHGEENYSETPLQLAAAVGNFELVSLLLERGADP 250
Cdd:cd21882  75 TALHIAIENRNLNLVRLLVENGADVSARAtgrffrksPGNLFYFGELPLSLAACTNQEEIVRLLLENGAQP 145
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 456-566 1.19e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 38.62  E-value: 1.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 456 KEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKptndntCIEIGYVKYPIFQLVMQYLYYGGpesLLIKNNEIMELL 535
Cdd:cd18275   2 LGEPDLVIEVSGQRIRAHKSVLAAKSDYFRARLSRD------ILKVKGLSYATLRLLVDYVYSGR---MAVSKDNVVEVV 72

                        90       100       110
                ....*....|....*....|....*....|..
gi 62953120 536 SAAKFFQLE-ALQRHCEIICAKsINTDNCVDI 566
Cdd:cd18275  73 AGARFLQMPcAAQCAVDAVRAQ-LCLGNCYEV 103
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 452-563 1.34e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 39.38  E-value: 1.34e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 452 FLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALL-SSKPTNDNTCIEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNE 530
Cdd:cd18268  17 LRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFcNNFRESSQAKVDLKGIDSDVLDQIVDYVYTG---EILITRDN 93

                        90       100       110
                ....*....|....*....|....*....|...
gi 62953120 531 IMELLSAAKFFQLEALQRHCEIICAKSINTDNC 563
Cdd:cd18268  94 VLPLMEAASMLQYPKLFEACSLYLQDQLTPENC 126
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 225-252 2.06e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.11  E-value: 2.06e-03
                          10        20
                  ....*....|....*....|....*....
gi 62953120   225 ETPLQLAAA-VGNFELVSLLLERGADPLI 252
Cdd:pfam00023   3 NTPLHLAAGrRGNLEIVKLLLSKGADVNA 31
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 458-550 2.13e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 38.51  E-value: 2.13e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 458 MSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTC-IEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNEIMELLS 536
Cdd:cd18338  21 LCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKrVRIKEVDGWTLKMLIDYVYTA---EIQVTEENVQVLLP 97

                        90
                ....*....|....
gi 62953120 537 AAKFFQLEALQRHC 550
Cdd:cd18338  98 AAGLLQLQDVKKTC 111
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 225-252 2.46e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.70  E-value: 2.46e-03
                          10        20
                  ....*....|....*....|....*...
gi 62953120   225 ETPLQLAAAVGNFELVSLLLERGADPLI 252
Cdd:pfam13606   3 NTPLHLAARNGRLEIVKLLLENGADINA 30
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 458-553 2.50e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 37.93  E-value: 2.50e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 458 MSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTCIEI-GYVKYPIFQLVMQYLYYGgpeSLLIKNNEIMELLS 536
Cdd:cd18215  19 LTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLKNNVSVINLdPEIEPEGFRILLDFMYTS---RLNLREGNIMAVMA 95

                        90
                ....*....|....*..
gi 62953120 537 AAKFFQLEALQRHCEII 553
Cdd:cd18215  96 TAMYLQMEHVVDTCRKF 112
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 443-566 2.64e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 38.50  E-value: 2.64e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 443 KQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTN-DNTCIEIGYVKYPIFQLVMQYLYYGgp 521
Cdd:cd18337   8 EQTFKKMENYLRHKQLCDVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREaKQEEIKMEGVEPNALWALVQYAYTG-- 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 62953120 522 eSLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCVDI 566
Cdd:cd18337  86 -RLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 129
Ank_4 pfam13637
Ankyrin repeats (many copies);
116-160 3.54e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.10  E-value: 3.54e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 62953120   116 GRTDLVKqavSLL--GPDgINTMSEQGMTPLMYACVRGDEAMVQMLL 160
Cdd:pfam13637  12 GHLELLR---LLLekGAD-INAVDGNGETALHFAASNGNVEVLKLLL 54
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 448-519 3.88e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 37.53  E-value: 3.88e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 62953120 448 LDPHFLNNKeMSDVTFLVEGRPFYAHKVLLFTASPRF--KALLsskptNDNTCIEIGYVKYP-IFQLVMQYLYYG 519
Cdd:cd18200   9 LNKHRLEGK-FCDLSVHVQGRVFRAHKAVLAASSPYFhdKLLL-----NDTNCLVLPSVIEAaAFENLLQLIYSG 77
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 223-250 4.43e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 4.43e-03
                           10        20
                   ....*....|....*....|....*...
gi 62953120    223 YSETPLQLAAAVGNFELVSLLLERGADP 250
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
Ank_5 pfam13857
Ankyrin repeats (many copies);
129-168 4.71e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.79  E-value: 4.71e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 62953120   129 GPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNV 168
Cdd:pfam13857   5 GPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNL 44
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 458-550 4.82e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 37.53  E-value: 4.82e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 458 MSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTCIEIG-YVKYPIFQLVMQYLYyggPESLLIKNNEIMELLS 536
Cdd:cd18331  24 LTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDpEINPEGFNILLDFMY---TSRLNLREGNIMAVMA 100

                        90
                ....*....|....
gi 62953120 537 AAKFFQLEALQRHC 550
Cdd:cd18331 101 TAMYLQMEHVVDTC 114
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 187-213 6.13e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 6.13e-03
                           10        20
                   ....*....|....*....|....*..
gi 62953120    187 WTALTFAVLHGHIPVVQLLLDAGAKVE 213
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGADIN 29
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 457-543 7.49e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 36.84  E-value: 7.49e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 457 EMSDVTFLVEGRPFYAHKVLLFTASPRF--KALLSskptNDNTCIEIGYVKYPIFQLVMQYLYYGGpesLLIKNNEIMEL 534
Cdd:cd18227  24 QLCDISVVVQGHLFRAHKAVLAASSPYFcdQVLLK----NSRRIVLPDVMNPRVFENILLSCYTGR---LVLPAPEIVSY 96


                ....*....
gi 62953120 535 LSAAKFFQL 543
Cdd:cd18227  97 LTAASFLQM 105
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 443-566 8.52e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 36.95  E-value: 8.52e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 443 KQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSS---KPTNDNTCIEiGYVKYPIFQLVmQYLYYG 519
Cdd:cd18335   4 EQTFRKMESYLKQQQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSdvcEAKQEEIKME-GIDPNALWDLV-QFAYTG 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 62953120 520 gpeSLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCVDI 566
Cdd:cd18335  82 ---CLELKEDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGI 125
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 458-550 8.84e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 36.55  E-value: 8.84e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62953120 458 MSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNdntcIEIGYVKYPIFQLVMQYLYyggPESLLIKNNEIMELLSA 537
Cdd:cd18205  18 LCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRNSQH----YTLDFLSPKTFQQILEYAY---TATLQAKVEDLDDLLYA 90

                        90
                ....*....|...
gi 62953120 538 AKFFQLEALQRHC 550
Cdd:cd18205  91 AEILEIEYLEEQC 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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