NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|62912462|ref|NP_001017364|]
View 

C4b-binding protein beta chain isoform 2 precursor [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 46-207 1.06e-16

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 77.00  E-value: 1.06e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912462   46 YVCIKGYHLVGKKTLFCNASKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVSDKITFMCNDHYILKGSNRSQCLEDHT 125
Cdd:PHA02927  52 YLCLPGYRKQKMGPIYAKCTGTGWTLFNQCIKRRCPSPRDIDNGQLDIGGVDFGSSITYSCNSGYQLIGESKSYCELGST 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912462  126 ----WAPPFPICKSRDCDPPGNPVHGYFEGNN--FTLGSTISYYCEDRYYLVGVQEQQCVDGEWSSAlPVCKLIQeAPKP 199
Cdd:PHA02927 132 gsmvWNPEAPICESVKCQSPPSISNGRHNGYEdfYTDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDP-PTCQIVK-CPHP 209


                 ....*...
gi 62912462  200 ECEKALLA 207
Cdd:PHA02927 210 TISNGYLS 217
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 46-207 1.06e-16

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 77.00  E-value: 1.06e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912462   46 YVCIKGYHLVGKKTLFCNASKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVSDKITFMCNDHYILKGSNRSQCLEDHT 125
Cdd:PHA02927  52 YLCLPGYRKQKMGPIYAKCTGTGWTLFNQCIKRRCPSPRDIDNGQLDIGGVDFGSSITYSCNSGYQLIGESKSYCELGST 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912462  126 ----WAPPFPICKSRDCDPPGNPVHGYFEGNN--FTLGSTISYYCEDRYYLVGVQEQQCVDGEWSSAlPVCKLIQeAPKP 199
Cdd:PHA02927 132 gsmvWNPEAPICESVKCQSPPSISNGRHNGYEdfYTDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDP-PTCQIVK-CPHP 209


                 ....*...
gi 62912462  200 ECEKALLA 207
Cdd:PHA02927 210 TISNGYLS 217
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 80-134 2.82e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 54.78  E-value: 2.82e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 62912462  80 CPDP-VLVNGEFS-SSGPVNVSDKITFMCNDHYILKGSNRSQCLEDHTWAPPFPICK 134
Cdd:cd00033   1 CPPPpVPENGTVTgSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
Sushi pfam00084
Sushi repeat (SCR repeat);
138-190 8.27e-10

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 53.27  E-value: 8.27e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 62912462   138 CDPPGNPVHGYFEG--NNFTLGSTISYYCEDRYYLVGVQEQQCV-DGEWSSALPVC 190
Cdd:pfam00084   1 CPPPPDIPNGKVSAtkNEYNYGASVSYECDPGYRLVGSPTITCQeDGTWSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 80-133 2.19e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 52.14  E-value: 2.19e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 62912462     80 CPDP-VLVNGEF-SSSGPVNVSDKITFMCNDHYILKGSNRSQCLEDHTWAPPFPIC 133
Cdd:smart00032   1 CPPPpDIENGTVtSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 46-207 1.06e-16

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 77.00  E-value: 1.06e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912462   46 YVCIKGYHLVGKKTLFCNASKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVSDKITFMCNDHYILKGSNRSQCLEDHT 125
Cdd:PHA02927  52 YLCLPGYRKQKMGPIYAKCTGTGWTLFNQCIKRRCPSPRDIDNGQLDIGGVDFGSSITYSCNSGYQLIGESKSYCELGST 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912462  126 ----WAPPFPICKSRDCDPPGNPVHGYFEGNN--FTLGSTISYYCEDRYYLVGVQEQQCVDGEWSSAlPVCKLIQeAPKP 199
Cdd:PHA02927 132 gsmvWNPEAPICESVKCQSPPSISNGRHNGYEdfYTDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDP-PTCQIVK-CPHP 209


                 ....*...
gi 62912462  200 ECEKALLA 207
Cdd:PHA02927 210 TISNGYLS 217
PHA02639 PHA02639
EEV host range protein; Provisional
 46-190 7.68e-15

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 72.39  E-value: 7.68e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912462   46 YVCIKGYHLVGKKTLFCNASKE---WDNTTTECRLGHCPDP-VLVNGE-FSSSGPVNVSDKITFMCNDH----YILKGSN 116
Cdd:PHA02639  48 YTCNTDYALIGDRFRTCIKDKNnaiWSNKAPFCMLKECNDPpSIINGKiYNKREMYKVGDEIYYVCNEHkgvqYSLVGNE 127

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62912462  117 RSQCLEDHTWAPPFPICKSRDCDPPGNPvHGYFEG----NNFTLGSTISYYCEDRYYLVGVQEQQC-VDGEWSSALPVC 190
Cdd:PHA02639 128 KITCIQDKSWKPDPPICKMINCRFPALQ-NGYINGipsnKKFYYKTRVGFSCKSGFDLVGEKYSTCnINATWFPSIPTC 205
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 22-133 1.30e-13

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 68.53  E-value: 1.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912462   22 CPELPPVDNSIFVAKE---VEGQILgTYVCIKGYHLVGKKTLFCNASkEWDNTTTeCRLGHCPDPVLVNGEFSSSGPVNV 98
Cdd:PHA02927 148 CQSPPSISNGRHNGYEdfyTDGSVV-TYSCNSGYSLIGNSGVLCSGG-EWSDPPT-CQIVKCPHPTISNGYLSSGFKRSY 224

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 62912462   99 S--DKITFMCNDHYILKGSNRSQCLEDHTWAPPFPIC 133
Cdd:PHA02927 225 SynDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKC 261
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 80-134 2.82e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 54.78  E-value: 2.82e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 62912462  80 CPDP-VLVNGEFS-SSGPVNVSDKITFMCNDHYILKGSNRSQCLEDHTWAPPFPICK 134
Cdd:cd00033   1 CPPPpVPENGTVTgSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 138-191 3.18e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 54.39  E-value: 3.18e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 62912462 138 CDPPGNPVHGYFEG--NNFTLGSTISYYCEDRYYLVGVQEQQCV-DGEWSSALPVCK 191
Cdd:cd00033   1 CPPPPVPENGTVTGskGSYSYGSTVTYSCNEGYTLVGSSTITCTeNGGWSPPPPTCE 57
Sushi pfam00084
Sushi repeat (SCR repeat);
138-190 8.27e-10

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 53.27  E-value: 8.27e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 62912462   138 CDPPGNPVHGYFEG--NNFTLGSTISYYCEDRYYLVGVQEQQCV-DGEWSSALPVC 190
Cdd:pfam00084   1 CPPPPDIPNGKVSAtkNEYNYGASVSYECDPGYRLVGSPTITCQeDGTWSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 80-133 2.19e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 52.14  E-value: 2.19e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 62912462     80 CPDP-VLVNGEF-SSSGPVNVSDKITFMCNDHYILKGSNRSQCLEDHTWAPPFPIC 133
Cdd:smart00032   1 CPPPpDIENGTVtSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 138-190 2.32e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 52.14  E-value: 2.32e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 62912462    138 CDPPGNPVHGYFEG--NNFTLGSTISYYCEDRYYLVGVQEQQCV-DGEWSSALPVC 190
Cdd:smart00032   1 CPPPPDIENGTVTSssGTYSYGDTVTYSCDPGYTLIGSSTITCLeNGTWSPPPPTC 56
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 22-190 3.20e-09

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 55.81  E-value: 3.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912462   22 CPELPPVDNSIFVAKEVEGQILGTYVCIKGYHLVGKKTLFC----NASKEWDNTTTECRLGHCPD-PVLVNG------EF 90
Cdd:PHA02927  86 CPSPRDIDNGQLDIGGVDFGSSITYSCNSGYQLIGESKSYCelgsTGSMVWNPEAPICESVKCQSpPSISNGrhngyeDF 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912462   91 SSSGPVnvsdkITFMCNDHYILKGSNRSQClEDHTWAPPfPICKSRDCDPPgNPVHGYFEGN---NFTLGSTISYYCEDR 167
Cdd:PHA02927 166 YTDGSV-----VTYSCNSGYSLIGNSGVLC-SGGEWSDP-PTCQIVKCPHP-TISNGYLSSGfkrSYSYNDNVDFKCKYG 237

                        170       180
                 ....*....|....*....|....
gi 62912462  168 YYLVGVQEQQCVDGE-WSSALPVC 190
Cdd:PHA02927 238 YKLSGSSSSTCSPGNtWQPELPKC 261
PHA02817 PHA02817
EEV Host range protein; Provisional
 80-190 2.35e-08

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 53.02  E-value: 2.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912462   80 CPDPVLVNGEFSSSGPV-NVSDKITFMCNDH-----YILKGSNRSQCLEDHTWAPPFPICKSRDCDPPG---NPVHGYFE 150
Cdd:PHA02817  25 CYPPSIKNGYIYNKKTEyNIGSNVTFFCGNNtrgvrYTLVGEKNIICEKDGKWNKEFPVCKIIRCRFPAlqnGFVNGIPD 104

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 62912462  151 GNNFTLGSTISYYCEDRYYLVGVQEQQC-VDGEWSSALPVC 190
Cdd:PHA02817 105 SKKFYYESEVSFSCKPGFVLIGTKYSVCgINSSWIPKVPIC 145
PHA02817 PHA02817
EEV Host range protein; Provisional
 52-137 3.48e-08

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 52.64  E-value: 3.48e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912462   52 YHLVGKKTLFCNASKEWDNTTTECRLGHCPDPVLVNGEFS---SSGPVNVSDKITFMCNDHYILKGSNRSQCLEDHTWAP 128
Cdd:PHA02817  61 YTLVGEKNIICEKDGKWNKEFPVCKIIRCRFPALQNGFVNgipDSKKFYYESEVSFSCKPGFVLIGTKYSVCGINSSWIP 140


                 ....*....
gi 62912462  129 PFPICKSRD 137
Cdd:PHA02817 141 KVPICSRDN 149
Sushi pfam00084
Sushi repeat (SCR repeat);
80-133 2.07e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 46.72  E-value: 2.07e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 62912462    80 CPDP-VLVNGEFSSS-GPVNVSDKITFMCNDHYILKGSNRSQCLEDHTWAPPFPIC 133
Cdd:pfam00084   1 CPPPpDIPNGKVSATkNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
PHA02639 PHA02639
EEV host range protein; Provisional
 102-193 4.01e-07

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 50.05  E-value: 4.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912462  102 ITFMCNDHYILKGSNRSQCLEDHT---WAPPFPICKSRDCDPPGNPVHG--YFEGNNFTLGSTISYYCED----RYYLVG 172
Cdd:PHA02639  46 IEYTCNTDYALIGDRFRTCIKDKNnaiWSNKAPFCMLKECNDPPSIINGkiYNKREMYKVGDEIYYVCNEhkgvQYSLVG 125

                         90       100
                 ....*....|....*....|..
gi 62912462  173 VQEQQCV-DGEWSSALPVCKLI 193
Cdd:PHA02639 126 NEKITCIqDKSWKPDPPICKMI 147
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 63-199 7.99e-07

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 49.31  E-value: 7.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912462   63 NASKEWDNTTTeCRLGHCPDPVLVNGefsSSGPV----NVSDKITFMCNDHYILKGSNRSQCLEDhTWAPpFPICKSRdC 138
Cdd:PHA02954 114 NGNTSWNDTVT-CPNAECQPLQLEHG---SCQPVkekySFGEHITINCDVGYEVIGASYISCTAN-SWNV-IPSCQQK-C 186

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62912462  139 DPPgNPVHGYFEGNNFTLGSTISYYCEDRYYLVGVQEQQCVDGEWSSALPVCKLIQEAPKP 199
Cdd:PHA02954 187 DIP-SLSNGLISGSTFSIGGVIHLSCKSGFTLTGSPSSTCIDGKWNPVLPICVRSNEEFDP 246
PHA02831 PHA02831
EEV host range protein; Provisional
 136-194 2.48e-06

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 47.29  E-value: 2.48e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 62912462  136 RDCDPPGNPVHGYFEG--NNFTLGSTISYYCE----DRYYLVGVQEQQCVDGEWSSALPVCKLIQ 194
Cdd:PHA02831  76 RNCKDPVTILNGYIKNkkDQYSFGDSVTYACKvnklEKYSIVGNETVKCINKQWVPKYPVCKLIR 140
PHA02831 PHA02831
EEV host range protein; Provisional
 45-133 3.87e-06

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 46.91  E-value: 3.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912462   45 TYVC----IKGYHLVGKKTLFCnASKEWDNTTTECRLGHCPDPVLVNGEFSS-SGPVNVSDKITFMCNDHYILKGSNRSQ 119
Cdd:PHA02831 103 TYACkvnkLEKYSIVGNETVKC-INKQWVPKYPVCKLIRCKYPALQNGFLNVfEKKFYYGDIVNFKCKKGFILLGSSVST 181

                         90
                 ....*....|....
gi 62912462  120 CLEDHTWAPPFPIC 133
Cdd:PHA02831 182 CDINSIWYPGIPKC 195
PHA02831 PHA02831
EEV host range protein; Provisional
 79-190 4.41e-06

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 46.52  E-value: 4.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912462   79 HCPDPVLV-NGEFSS-SGPVNVSDKITFMCN----DHYILKGSNRSQCLeDHTWAPPFPICKSRDCDPPG--NPVHGYFE 150
Cdd:PHA02831  77 NCKDPVTIlNGYIKNkKDQYSFGDSVTYACKvnklEKYSIVGNETVKCI-NKQWVPKYPVCKLIRCKYPAlqNGFLNVFE 155

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 62912462  151 gNNFTLGSTISYYCEDRYYLVGVQEQQC-VDGEWSSALPVC 190
Cdd:PHA02831 156 -KKFYYGDIVNFKCKKGFILLGSSVSTCdINSIWYPGIPKC 195
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 22-76 4.91e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 42.84  E-value: 4.91e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 62912462  22 CPELPPVDNSIFV---AKEVEGQILgTYVCIKGYHLVGKKTLFCNASKEWDNTTTECR 76
Cdd:cd00033   1 CPPPPVPENGTVTgskGSYSYGSTV-TYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 22-75 1.70e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 41.36  E-value: 1.70e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 62912462     22 CPELPPVDNSIFVAKE---VEGQILgTYVCIKGYHLVGKKTLFCNASKEWDNTTTEC 75
Cdd:smart00032   1 CPPPPDIENGTVTSSSgtySYGDTV-TYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 97-199 4.28e-04

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 40.79  E-value: 4.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912462   97 NVSDKITFMCNDHYILK--GSNRSQClEDHTWAPpFPICKSRDCDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVGVQ 174
Cdd:PHA02927  45 NIGDTIEYLCLPGYRKQkmGPIYAKC-TGTGWTL-FNQCIKRRCPSPRDIDNGQLDIGGVDFGSSITYSCNSGYQLIGES 122

                         90       100       110
                 ....*....|....*....|....*....|
gi 62912462  175 EQQCVDGE-----WSSALPVCKLIQEAPKP 199
Cdd:PHA02927 123 KSYCELGStgsmvWNPEAPICESVKCQSPP 152
PHA02817 PHA02817
EEV Host range protein; Provisional
 133-193 2.81e-03

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 38.00  E-value: 2.81e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62912462  133 CKSRDCDPPGNPVHGYF--EGNNFTLGSTISYYCED-----RYYLVGVQEQQC-VDGEWSSALPVCKLI 193
Cdd:PHA02817  19 CDLNKCCYPPSIKNGYIynKKTEYNIGSNVTFFCGNntrgvRYTLVGEKNIICeKDGKWNKEFPVCKII 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH