barrier-to-autointegration factor-like protein isoform 1 [Homo sapiens]
List of domain hits
Name | Accession | Description | Interval | E-value | |||
BAF super family | cl03803 | Barrier to autointegration factor; The BAF protein has a SAM-domain-like bundle of ... |
3-89 | 7.86e-49 | |||
Barrier to autointegration factor; The BAF protein has a SAM-domain-like bundle of orthogonally packed alpha-hairpins - one classic and one pseudo helix-hairpin-helix motif. The protein is involved in the prevention of retroviral DNA integration. The actual alignment was detected with superfamily member smart01023: Pssm-ID: 470880 Cd Length: 87 Bit Score: 149.42 E-value: 7.86e-49
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Name | Accession | Description | Interval | E-value | |||
BAF | smart01023 | Barrier to autointegration factor; Barrier-to-autointegration factor (BAF) is an essential ... |
3-89 | 7.86e-49 | |||
Barrier to autointegration factor; Barrier-to-autointegration factor (BAF) is an essential protein that is highly conserved in metazoan evolution, and which may act as a DNA-bridging protein. BAF binds directly to double-stranded DNA, to transcription activators, and to inner nuclear membrane proteins, including lamin A filament proteins that anchor nuclear-pore complexes in place, and nuclear LEM-domain proteins that bind to laminins filaments and chromatin. New findings suggest that BAF has structural roles in nuclear assembly and chromatin organization, represses gene expression and might interlink chromatin structure, nuclear architecture and gene regulation in metazoans. BAF can be exploited by retroviruses to act as a host component of pre-integration complexes, which promote the integration of the retroviral DNA into the host chromosome by preventing autointegration of retroviral DNA. BAF might contribute to the assembly or activity of retroviral pre-integration complexes through direct binding to the retroviral proteins p55 Gag and matrix, as well as to DNA. Pssm-ID: 198091 Cd Length: 87 Bit Score: 149.42 E-value: 7.86e-49
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BAF | pfam02961 | Barrier to autointegration factor; The BAF protein has a SAM-domain-like bundle of ... |
4-89 | 1.29e-45 | |||
Barrier to autointegration factor; The BAF protein has a SAM-domain-like bundle of orthogonally packed alpha-hairpins - one classic and one pseudo helix-hairpin-helix motif. The protein is involved in the prevention of retroviral DNA integration. Pssm-ID: 460766 Cd Length: 88 Bit Score: 141.18 E-value: 1.29e-45
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Name | Accession | Description | Interval | E-value | |||
BAF | smart01023 | Barrier to autointegration factor; Barrier-to-autointegration factor (BAF) is an essential ... |
3-89 | 7.86e-49 | |||
Barrier to autointegration factor; Barrier-to-autointegration factor (BAF) is an essential protein that is highly conserved in metazoan evolution, and which may act as a DNA-bridging protein. BAF binds directly to double-stranded DNA, to transcription activators, and to inner nuclear membrane proteins, including lamin A filament proteins that anchor nuclear-pore complexes in place, and nuclear LEM-domain proteins that bind to laminins filaments and chromatin. New findings suggest that BAF has structural roles in nuclear assembly and chromatin organization, represses gene expression and might interlink chromatin structure, nuclear architecture and gene regulation in metazoans. BAF can be exploited by retroviruses to act as a host component of pre-integration complexes, which promote the integration of the retroviral DNA into the host chromosome by preventing autointegration of retroviral DNA. BAF might contribute to the assembly or activity of retroviral pre-integration complexes through direct binding to the retroviral proteins p55 Gag and matrix, as well as to DNA. Pssm-ID: 198091 Cd Length: 87 Bit Score: 149.42 E-value: 7.86e-49
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BAF | pfam02961 | Barrier to autointegration factor; The BAF protein has a SAM-domain-like bundle of ... |
4-89 | 1.29e-45 | |||
Barrier to autointegration factor; The BAF protein has a SAM-domain-like bundle of orthogonally packed alpha-hairpins - one classic and one pseudo helix-hairpin-helix motif. The protein is involved in the prevention of retroviral DNA integration. Pssm-ID: 460766 Cd Length: 88 Bit Score: 141.18 E-value: 1.29e-45
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Blast search parameters | ||||
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