NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|62079043|ref|NP_001014176|]
View 

dynein axonemal assembly factor 1 [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 106-290 3.90e-40

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 146.08  E-value: 3.90e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62079043 106 LYLHFKGFDRIENLEEYTGLRCLWLECNGIQRIENLQAQSELRCLFLQVNLLHKIENLEPLQKLDALNLSNNYIKTIENL 185
Cdd:cd21340   7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62079043 186 SCLPVLNTLQM------------------------------AHNRLETVADIEHLReclQLCVLDLSHNSLSD-PEILSV 234
Cdd:cd21340  87 ENLTNLEELHIenqrlppgekltfdprslaalsnslrvlniSGNNIDSLEPLAPLR---NLEQLDASNNQISDlEELLDL 163

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 62079043 235 LETMPCLRVLNLMGNPVTKhIPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWAR 290
Cdd:cd21340 164 LSSWPSLRELDLTGNPVCK-KPKYRDKIILASKSLEVLDGKEITDTERQFLKRLKA 218
PTZ00121 super family cl31754
MAEBL; Provisional
 294-379 2.48e-03

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.28  E-value: 2.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62079043   294 AAEKEERHQWESREHKKITDSLEALAMIKRRAEERKKARDRGETPLPESEKSIPTSPEAQEKPPKGETQQKMESFVKESF 373
Cdd:PTZ00121 1362 AEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAE 1441


                  ....*...
gi 62079043   374 EAK--DEL 379
Cdd:PTZ00121 1442 EAKkaDEA 1449
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 106-290 3.90e-40

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 146.08  E-value: 3.90e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62079043 106 LYLHFKGFDRIENLEEYTGLRCLWLECNGIQRIENLQAQSELRCLFLQVNLLHKIENLEPLQKLDALNLSNNYIKTIENL 185
Cdd:cd21340   7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62079043 186 SCLPVLNTLQM------------------------------AHNRLETVADIEHLReclQLCVLDLSHNSLSD-PEILSV 234
Cdd:cd21340  87 ENLTNLEELHIenqrlppgekltfdprslaalsnslrvlniSGNNIDSLEPLAPLR---NLEQLDASNNQISDlEELLDL 163

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 62079043 235 LETMPCLRVLNLMGNPVTKhIPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWAR 290
Cdd:cd21340 164 LSSWPSLRELDLTGNPVCK-KPKYRDKIILASKSLEVLDGKEITDTERQFLKRLKA 218
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
105-273 5.88e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.28  E-value: 5.88e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62079043 105 TLYLHFKGFDRI-ENLEEYTGLRCLWLECNGIQRI-ENLQAQSELRCLFLQVNLLHKI-ENLEPLQKLDALNLSNNYIKT 181
Cdd:COG4886 117 SLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITD 196

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62079043 182 I-ENLSCLPVLNTLQMAHNRLETVAdiEHLRECLQLCVLDLSHNSLSDpeiLSVLETMPCLRVLNLMGNPVTkHIPNyrr 260
Cdd:COG4886 197 LpEPLGNLTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQLTD---LPELGNLTNLEELDLSNNQLT-DLPP--- 267

                       170
                ....*....|...
gi 62079043 261 tvTVRLKHLTYLD 273
Cdd:COG4886 268 --LANLTNLKTLD 278
LRR_9 pfam14580
Leucine-rich repeat;
160-296 3.87e-13

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 67.87  E-value: 3.87e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62079043   160 IENL-EPLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNRLETVAdiEHLRECL-QLCVLDLSHNSLSDPEILSVLET 237
Cdd:pfam14580  34 IENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIG--EGLGEALpNLTELILTNNNLQELGDLDPLAS 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 62079043   238 MPCLRVLNLMGNPVTKHiPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWARGGYAAE 296
Cdd:pfam14580 112 LKKLTFLSLLRNPVTNK-PHYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQGKQ 169
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 167-268 3.76e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.68  E-value: 3.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62079043  167 QKLDALNLSNNYIKTI--ENLSCLPVLNTLQMAHNRLETVADIEhLRECLQLCVLDLSHNSLSDpEILSVLETMPCLRVL 244
Cdd:PLN00113 475 KRLENLDLSRNQFSGAvpRKLGSLSELMQLKLSENKLSGEIPDE-LSSCKKLVSLDLSHNQLSG-QIPASFSEMPVLSQL 552

                         90       100
                 ....*....|....*....|....*...
gi 62079043  245 NLMGNPVTKHIP----NYRRTVTVRLKH 268
Cdd:PLN00113 553 DLSQNQLSGEIPknlgNVESLVQVNISH 580
PTZ00121 PTZ00121
MAEBL; Provisional
 294-379 2.48e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.28  E-value: 2.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62079043   294 AAEKEERHQWESREHKKITDSLEALAMIKRRAEERKKARDRGETPLPESEKSIPTSPEAQEKPPKGETQQKMESFVKESF 373
Cdd:PTZ00121 1362 AEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAE 1441


                  ....*...
gi 62079043   374 EAK--DEL 379
Cdd:PTZ00121 1442 EAKkaDEA 1449
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 106-290 3.90e-40

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 146.08  E-value: 3.90e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62079043 106 LYLHFKGFDRIENLEEYTGLRCLWLECNGIQRIENLQAQSELRCLFLQVNLLHKIENLEPLQKLDALNLSNNYIKTIENL 185
Cdd:cd21340   7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62079043 186 SCLPVLNTLQM------------------------------AHNRLETVADIEHLReclQLCVLDLSHNSLSD-PEILSV 234
Cdd:cd21340  87 ENLTNLEELHIenqrlppgekltfdprslaalsnslrvlniSGNNIDSLEPLAPLR---NLEQLDASNNQISDlEELLDL 163

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 62079043 235 LETMPCLRVLNLMGNPVTKhIPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWAR 290
Cdd:cd21340 164 LSSWPSLRELDLTGNPVCK-KPKYRDKIILASKSLEVLDGKEITDTERQFLKRLKA 218
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
105-273 5.88e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.28  E-value: 5.88e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62079043 105 TLYLHFKGFDRI-ENLEEYTGLRCLWLECNGIQRI-ENLQAQSELRCLFLQVNLLHKI-ENLEPLQKLDALNLSNNYIKT 181
Cdd:COG4886 117 SLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITD 196

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62079043 182 I-ENLSCLPVLNTLQMAHNRLETVAdiEHLRECLQLCVLDLSHNSLSDpeiLSVLETMPCLRVLNLMGNPVTkHIPNyrr 260
Cdd:COG4886 197 LpEPLGNLTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQLTD---LPELGNLTNLEELDLSNNQLT-DLPP--- 267

                       170
                ....*....|...
gi 62079043 261 tvTVRLKHLTYLD 273
Cdd:COG4886 268 --LANLTNLKTLD 278
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
105-252 7.56e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.81  E-value: 7.56e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62079043 105 TLYLHFKGFDRI-ENLEEYTGLRCLWLECNGIQRI-ENLQAQSELRCLFLQVNLLHKI-ENLEPLQKLDALNLSNNYIKT 181
Cdd:COG4886 140 ELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTD 219

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62079043 182 I-ENLSCLPVLNTLQMAHNRLETVADIEHLReclQLCVLDLSHNSLSDpeiLSVLETMPCLRVLNLMGNPVT 252
Cdd:COG4886 220 LpEPLANLTNLETLDLSNNQLTDLPELGNLT---NLEELDLSNNQLTD---LPPLANLTNLKTLDLSNNQLT 285
LRR_9 pfam14580
Leucine-rich repeat;
160-296 3.87e-13

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 67.87  E-value: 3.87e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62079043   160 IENL-EPLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNRLETVAdiEHLRECL-QLCVLDLSHNSLSDPEILSVLET 237
Cdd:pfam14580  34 IENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIG--EGLGEALpNLTELILTNNNLQELGDLDPLAS 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 62079043   238 MPCLRVLNLMGNPVTKHiPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWARGGYAAE 296
Cdd:pfam14580 112 LKKLTFLSLLRNPVTNK-PHYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQGKQ 169
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
95-273 1.47e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.33  E-value: 1.47e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62079043  95 KLYVTPALNDTLYLHFKGFDRIENLEEYTGLRCLWLECNGIQRIENLQAQSELRCLFLQVNllhkiENLEPLQKLDALNL 174
Cdd:COG4886  46 LLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDL 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62079043 175 SNNYIKTI-ENLSCLPVLNTLQMAHNRLETVAdiEHLRECLQLCVLDLSHNSLSD-PEILSVLETmpcLRVLNLMGNPVT 252
Cdd:COG4886 121 SGNQLTDLpEELANLTNLKELDLSNNQLTDLP--EPLGNLTNLKSLDLSNNQLTDlPEELGNLTN---LKELDLSNNQIT 195

                       170       180
                ....*....|....*....|.
gi 62079043 253 KhIPNyrrTVTvRLKHLTYLD 273
Cdd:COG4886 196 D-LPE---PLG-NLTNLEELD 211
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
105-238 2.48e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.48  E-value: 2.48e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62079043 105 TLYLHFKGFDRI-ENLEEYTGLRCLWLECNGIQRI-ENLQAQSELRCLFLQVNLLHKIENLEPLQKLDALNLSNNYIKTI 182
Cdd:COG4886 186 ELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDL 265

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 62079043 183 ENLSCLPVLNTLQMAHNRLeTVADIEHLRECLQLCVLDLSHNSLSDPEILSVLETM 238
Cdd:COG4886 266 PPLANLTNLKTLDLSNNQL-TDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
101-273 3.98e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.63  E-value: 3.98e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62079043 101 ALNDTLYLHFKGFDRIENLEEYTGLRCLWLECNGIQRIENLQAQSELRCLFLQVNLLHKIENLEPLQKLDALNLSNNyik 180
Cdd:COG4886  30 LLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN--- 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62079043 181 tiENLSCLPVLNTLQMAHNRLETV-ADIEHLReclQLCVLDLSHNSLSDpeILSVLETMPCLRVLNLMGNPVTkHIPNyr 259
Cdd:COG4886 107 --EELSNLTNLESLDLSGNQLTDLpEELANLT---NLKELDLSNNQLTD--LPEPLGNLTNLKSLDLSNNQLT-DLPE-- 176

                       170
                ....*....|....
gi 62079043 260 rtVTVRLKHLTYLD 273
Cdd:COG4886 177 --ELGNLTNLKELD 188
LRR_8 pfam13855
Leucine rich repeat;
145-201 1.10e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.10e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62079043   145 SELRCLFLQVNLLHKI--ENLEPLQKLDALNLSNNYIKTIEN--LSCLPVLNTLQMAHNRL 201
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 116-252 2.39e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.58  E-value: 2.39e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62079043 116 IENLEEYTGLRCLWLECNGIQ-----RIENLQAQSELRCLFLQVNLL------HKIENLEPLQ-KLDALNLSNNyikTIE 183
Cdd:cd00116  74 LQGLTKGCGLQELDLSDNALGpdgcgVLESLLRSSSLQELKLNNNGLgdrglrLLAKGLKDLPpALEKLVLGRN---RLE 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62079043 184 NLSCLPVLNTLQmAHNRLETV---------ADIEHLRECL----QLCVLDLSHNSLSDPEI--LS-VLETMPCLRVLNLM 247
Cdd:cd00116 151 GASCEALAKALR-ANRDLKELnlanngigdAGIRALAEGLkancNLEVLDLNNNGLTDEGAsaLAeTLASLKSLEVLNLG 229


                ....*
gi 62079043 248 GNPVT 252
Cdd:cd00116 230 DNNLT 234
LRR_8 pfam13855
Leucine rich repeat;
189-251 3.76e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 3.76e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 62079043   189 PVLNTLQMAHNRLETVADiEHLRECLQLCVLDLSHNSLS--DPEilsVLETMPCLRVLNLMGNPV 251
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDD-GAFKGLSNLKVLDLSNNLLTtlSPG---AFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 106-252 5.11e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.94  E-value: 5.11e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62079043 106 LYLHFKGFDRIENLEEYTGLRCLWLECNGIQRI-ENLQAQSELRCLFLQVNLLHK------IENLEPLQKLDALNLSNNY 178
Cdd:COG5238 168 LAAISMAKALQNNSVETVYLGCNQIGDEGIEELaEALTQNTTVTTLWLKRNPIGDegaeilAEALKGNKSLTTLDLSNNQ 247

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62079043 179 IKT------IENLSCLPVLNTLQMAHNRLE---TVADIEHLRECLQLCVLDLSHNSLSDP---EILSVLETMPCLRVLNL 246
Cdd:COG5238 248 IGDegvialAEALKNNTTVETLYLSGNQIGaegAIALAKALQGNTTLTSLDLSVNRIGDEgaiALAEGLQGNKTLHTLNL 327


                ....*.
gi 62079043 247 MGNPVT 252
Cdd:COG5238 328 AYNGIG 333
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 167-212 1.23e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.92  E-value: 1.23e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 62079043   167 QKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNRLetVADIEHLRE 212
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNK--ITDLSDLAN 44
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 117-254 1.62e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.40  E-value: 1.62e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62079043 117 ENLEEYTGLRCLWLECNGIQR------IENLQAQSELRCLFLQVN------LLHKIENLEPLQKLDALNLSNNYIKT--- 181
Cdd:COG5238 202 EALTQNTTVTTLWLKRNPIGDegaeilAEALKGNKSLTTLDLSNNqigdegVIALAEALKNNTTVETLYLSGNQIGAega 281

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62079043 182 ---IENLSCLPVLNTLQMAHNRLE---TVADIEHLRECLQLCVLDLSHNSLSDPE---ILSVLETMPCLRVLNLMGNPVT 252
Cdd:COG5238 282 ialAKALQGNTTLTSLDLSVNRIGdegAIALAEGLQGNKTLHTLNLAYNGIGAQGaiaLAKALQENTTLHSLDLSDNQIG 361


                ..
gi 62079043 253 KH 254
Cdd:COG5238 362 DE 363
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 147-186 1.63e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.54  E-value: 1.63e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 62079043   147 LRCLFLQVNLLHKIENLEPLQKLDALNLS-NNYIKTIENLS 186
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSgNNKITDLSDLA 43
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 215-259 1.70e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.54  E-value: 1.70e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 62079043   215 QLCVLDLSHNSLSDpeiLSVLETMPCLRVLNLMGNPVTKHIPNYR 259
Cdd:pfam12799   2 NLEVLDLSNNQITD---IPPLAKLPNLETLDLSGNNKITDLSDLA 43
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 116-253 3.14e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 43.63  E-value: 3.14e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62079043 116 IENLEEYTGLRCLWLECNGIQR------IENLQAQSELRCLFLQVNllhkienlePLQKLDALNLsnnyiktIENLSCLP 189
Cdd:COG5238 257 AEALKNNTTVETLYLSGNQIGAegaialAKALQGNTTLTSLDLSVN---------RIGDEGAIAL-------AEGLQGNK 320

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62079043 190 VLNTLQMAHNRL---ETVADIEHLRECLQLCVLDLSHNSLSDP---EILSVLETMPCLRVLNLMGNPVTK 253
Cdd:COG5238 321 TLHTLNLAYNGIgaqGAIALAKALQENTTLHSLDLSDNQIGDEgaiALAKYLEGNTTLRELNLGKNNIGK 390
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 167-268 3.76e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.68  E-value: 3.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62079043  167 QKLDALNLSNNYIKTI--ENLSCLPVLNTLQMAHNRLETVADIEhLRECLQLCVLDLSHNSLSDpEILSVLETMPCLRVL 244
Cdd:PLN00113 475 KRLENLDLSRNQFSGAvpRKLGSLSELMQLKLSENKLSGEIPDE-LSSCKKLVSLDLSHNQLSG-QIPASFSEMPVLSQL 552

                         90       100
                 ....*....|....*....|....*...
gi 62079043  245 NLMGNPVTKHIP----NYRRTVTVRLKH 268
Cdd:PLN00113 553 DLSQNQLSGEIPknlgNVESLVQVNISH 580
PLN03150 PLN03150
hypothetical protein; Provisional
 166-256 6.03e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.88  E-value: 6.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62079043  166 LQKLDALNLSNNYIKTIENLSclpvlntlqmahnrLETVADIEhlreclqlcVLDLSHNSL--SDPEILSVLETmpcLRV 243
Cdd:PLN03150 441 LRHLQSINLSGNSIRGNIPPS--------------LGSITSLE---------VLDLSYNSFngSIPESLGQLTS---LRI 494

                         90
                 ....*....|...
gi 62079043  244 LNLMGNPVTKHIP 256
Cdd:PLN03150 495 LNLNGNSLSGRVP 507
PTZ00121 PTZ00121
MAEBL; Provisional
 294-379 2.48e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.28  E-value: 2.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62079043   294 AAEKEERHQWESREHKKITDSLEALAMIKRRAEERKKARDRGETPLPESEKSIPTSPEAQEKPPKGETQQKMESFVKESF 373
Cdd:PTZ00121 1362 AEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAE 1441


                  ....*...
gi 62079043   374 EAK--DEL 379
Cdd:PTZ00121 1442 EAKkaDEA 1449
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH