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Conserved domains on  [gi|61743971|ref|NP_001013455|]
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nucleoporin SEH1 isoform 1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
11-328 4.77e-28

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 114.24  E-value: 4.77e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971  11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDkseSGDWHCTASWKTHSGSVWRVTWAHPefGQVLASCSFDRTAAVWEEIV 90
Cdd:COG2319 119 HTGAVRSVAFSPDGKTLASGSADGTVRLWD---LATGKLLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLAT 193

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971  91 GESNDKLRGQSHWvkrttlvdsrtsVTDVKFAPKhmGLMLATCSADGIVRIYEAPDvmNLSQWSLQHEIScklSCSCISW 170
Cdd:COG2319 194 GKLLRTLTGHTGA------------VRSVAFSPD--GKLLASGSADGTVRLWDLAT--GKLLRTLTGHSG---SVRSVAF 254

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971 171 NPSSSRahspmIAVGSDDSSpnamakVQIFeyneNTRKYAKAETLMTVTDPVHDIAFAPNlGRsfhILAIATKD--VRIF 248
Cdd:COG2319 255 SPDGRL-----LASGSADGT------VRLW----DLATGELLRTLTGHSGGVNSVAFSPD-GK---LLASGSDDgtVRLW 315

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971 249 TLKPVRkeltssggptkfeihIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKAnymDNWKCTGILKGNGSPVNG 328
Cdd:COG2319 316 DLATGK---------------LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL---ATGELLRTLTGHTGAVTS 377
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
11-328 4.77e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 114.24  E-value: 4.77e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971  11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDkseSGDWHCTASWKTHSGSVWRVTWAHPefGQVLASCSFDRTAAVWEEIV 90
Cdd:COG2319 119 HTGAVRSVAFSPDGKTLASGSADGTVRLWD---LATGKLLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLAT 193

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971  91 GESNDKLRGQSHWvkrttlvdsrtsVTDVKFAPKhmGLMLATCSADGIVRIYEAPDvmNLSQWSLQHEIScklSCSCISW 170
Cdd:COG2319 194 GKLLRTLTGHTGA------------VRSVAFSPD--GKLLASGSADGTVRLWDLAT--GKLLRTLTGHSG---SVRSVAF 254

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971 171 NPSSSRahspmIAVGSDDSSpnamakVQIFeyneNTRKYAKAETLMTVTDPVHDIAFAPNlGRsfhILAIATKD--VRIF 248
Cdd:COG2319 255 SPDGRL-----LASGSADGT------VRLW----DLATGELLRTLTGHSGGVNSVAFSPD-GK---LLASGSDDgtVRLW 315

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971 249 TLKPVRkeltssggptkfeihIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKAnymDNWKCTGILKGNGSPVNG 328
Cdd:COG2319 316 DLATGK---------------LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL---ATGELLRTLTGHTGAVTS 377
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-306 3.84e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 106.65  E-value: 3.84e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971  11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSesgDWHCTASWKTHSGSVWRVTWaHPEfGQVLASCSFDRTAAVWEEIV 90
Cdd:cd00200  50 HTGPVRDVAASADGTYLASGSSDKTIRLWDLE---TGECVRTLTGHTSYVSSVAF-SPD-GRILSSSSRDKTIKVWDVET 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971  91 GESNDKLRGQSHWVkrttlvdsrtsvTDVKFAPKHMglMLATCSADGIVRIYeapdvmNLSQWSLQHEISC-KLSCSCIS 169
Cdd:cd00200 125 GKCLTTLRGHTDWV------------NSVAFSPDGT--FVASSSQDGTIKLW------DLRTGKCVATLTGhTGEVNSVA 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971 170 WNPSSSRahspmIAVGSDDSSpnamakVQIFEynenTRKYAKAETLMTVTDPVHDIAFAPNLgrsfHILAIATKD--VRI 247
Cdd:cd00200 185 FSPDGEK-----LLSSSSDGT------IKLWD----LSTGKCLGTLRGHENGVNSVAFSPDG----YLLASGSEDgtIRV 245

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 61743971 248 FTLKPVRkeltssggptkfeihIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWK 306
Cdd:cd00200 246 WDLRTGE---------------CVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 271-306 3.44e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 3.44e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 61743971    271 VAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWK 306
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
271-305 1.47e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.47e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 61743971   271 VAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLW 305
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
11-328 4.77e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 114.24  E-value: 4.77e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971  11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDkseSGDWHCTASWKTHSGSVWRVTWAHPefGQVLASCSFDRTAAVWEEIV 90
Cdd:COG2319 119 HTGAVRSVAFSPDGKTLASGSADGTVRLWD---LATGKLLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLAT 193

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971  91 GESNDKLRGQSHWvkrttlvdsrtsVTDVKFAPKhmGLMLATCSADGIVRIYEAPDvmNLSQWSLQHEIScklSCSCISW 170
Cdd:COG2319 194 GKLLRTLTGHTGA------------VRSVAFSPD--GKLLASGSADGTVRLWDLAT--GKLLRTLTGHSG---SVRSVAF 254

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971 171 NPSSSRahspmIAVGSDDSSpnamakVQIFeyneNTRKYAKAETLMTVTDPVHDIAFAPNlGRsfhILAIATKD--VRIF 248
Cdd:COG2319 255 SPDGRL-----LASGSADGT------VRLW----DLATGELLRTLTGHSGGVNSVAFSPD-GK---LLASGSDDgtVRLW 315

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971 249 TLKPVRkeltssggptkfeihIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKAnymDNWKCTGILKGNGSPVNG 328
Cdd:COG2319 316 DLATGK---------------LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL---ATGELLRTLTGHTGAVTS 377
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-306 3.84e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 106.65  E-value: 3.84e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971  11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSesgDWHCTASWKTHSGSVWRVTWaHPEfGQVLASCSFDRTAAVWEEIV 90
Cdd:cd00200  50 HTGPVRDVAASADGTYLASGSSDKTIRLWDLE---TGECVRTLTGHTSYVSSVAF-SPD-GRILSSSSRDKTIKVWDVET 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971  91 GESNDKLRGQSHWVkrttlvdsrtsvTDVKFAPKHMglMLATCSADGIVRIYeapdvmNLSQWSLQHEISC-KLSCSCIS 169
Cdd:cd00200 125 GKCLTTLRGHTDWV------------NSVAFSPDGT--FVASSSQDGTIKLW------DLRTGKCVATLTGhTGEVNSVA 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971 170 WNPSSSRahspmIAVGSDDSSpnamakVQIFEynenTRKYAKAETLMTVTDPVHDIAFAPNLgrsfHILAIATKD--VRI 247
Cdd:cd00200 185 FSPDGEK-----LLSSSSDGT------IKLWD----LSTGKCLGTLRGHENGVNSVAFSPDG----YLLASGSEDgtIRV 245

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 61743971 248 FTLKPVRkeltssggptkfeihIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWK 306
Cdd:cd00200 246 WDLRTGE---------------CVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
11-308 6.02e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.46  E-value: 6.02e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971  11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDkseSGDWHCTASWKTHSGSVWRVTWAHPefGQVLASCSFDRTAAVWEeiv 90
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWD---LATGKLLRTLTGHTGAVRSVAFSPD--GKLLASGSADGTVRLWD--- 232

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971  91 gesndkLRGQSHwvkRTTLVDSRTSVTDVKFAPKhmGLMLATCSADGIVRIYEAPDvmNLSQWSLQHEIScklSCSCISW 170
Cdd:COG2319 233 ------LATGKL---LRTLTGHSGSVRSVAFSPD--GRLLASGSADGTVRLWDLAT--GELLRTLTGHSG---GVNSVAF 296

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971 171 NPSSSRahspmIAVGSDDSSpnamakVQIFeyneNTRKYAKAETLMTVTDPVHDIAFAPNlGRsfhILAIATKD--VRIF 248
Cdd:COG2319 297 SPDGKL-----LASGSDDGT------VRLW----DLATGKLLRTLTGHTGAVRSVAFSPD-GK---TLASGSDDgtVRLW 357

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971 249 TLKPVRKELTSSGgptkfeihivaqfdnHNSQVWRVSWNITGTVLASSGDDGCVRLWKAN 308
Cdd:COG2319 358 DLATGELLRTLTG---------------HTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-327 5.05e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.09  E-value: 5.05e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971  11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESgdwHCTASWKTHSGSVWRVTWAHpeFGQVLASCSFDRTAAVWEEIV 90
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG---ELLRTLKGHTGPVRDVAASA--DGTYLASGSSDKTIRLWDLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971  91 GESNDKLRGQSHWvkrttlvdsrtsVTDVKFAPKhmGLMLATCSADGIVRIYEAPDVMNLSQWSlqheiSCKLSCSCISW 170
Cdd:cd00200  83 GECVRTLTGHTSY------------VSSVAFSPD--GRILSSSSRDKTIKVWDVETGKCLTTLR-----GHTDWVNSVAF 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971 171 NPSSSrahspMIAVGSDDSSpnamakvqIFEYNENTRKYAKaeTLMTVTDPVHDIAFAPNLGRsfHILAIATKDVRIFTL 250
Cdd:cd00200 144 SPDGT-----FVASSSQDGT--------IKLWDLRTGKCVA--TLTGHTGEVNSVAFSPDGEK--LLSSSSDGTIKLWDL 206

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 61743971 251 KpvrkeltssggptkfEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKanyMDNWKCTGILKGNGSPVN 327
Cdd:cd00200 207 S---------------TGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWD---LRTGECVQTLSGHTNSVT 265
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 49-328 5.48e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.84  E-value: 5.48e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971  49 CTASWKTHSGSVWRVTWaHPEfGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSvtdvkfapkhmgl 128
Cdd:cd00200   1 LRRTLKGHTGGVTCVAF-SPD-GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY------------- 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971 129 mLATCSADGIVRIYeapdvmNLSQWSLQHEISC-KLSCSCISWNPsssraHSPMIAVGSDDSSpnamakVQIFEYNENTR 207
Cdd:cd00200  66 -LASGSSDKTIRLW------DLETGECVRTLTGhTSYVSSVAFSP-----DGRILSSSSRDKT------IKVWDVETGKC 127

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971 208 KYakaeTLMTVTDPVHDIAFAPNLgrsfHILAIATKD--VRIFTLKpvrkeltssggptkfEIHIVAQFDNHNSQVWRVS 285
Cdd:cd00200 128 LT----TLRGHTDWVNSVAFSPDG----TFVASSSQDgtIKLWDLR---------------TGKCVATLTGHTGEVNSVA 184

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 61743971 286 WNITGTVLASSGDDGCVRLWKanyMDNWKCTGILKGNGSPVNG 328
Cdd:cd00200 185 FSPDGEKLLSSSSDGTIKLWD---LSTGKCLGTLRGHENGVNS 224
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-190 9.96e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 74.29  E-value: 9.96e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971  10 DHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSEsgdWHCTASWKTHSGSVWRVTWaHPEfGQVLASCSFDRTAAVWEei 89
Cdd:cd00200 133 GHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT---GKCVATLTGHTGEVNSVAF-SPD-GEKLLSSSSDGTIKLWD-- 205

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971  90 vgesndkLRGQsHWVKrtTLVDSRTSVTDVKFAPKhmGLMLATCSADGIVRIYeapdvmNLSQWSLQHEISC-KLSCSCI 168
Cdd:cd00200 206 -------LSTG-KCLG--TLRGHENGVNSVAFSPD--GYLLASGSEDGTIRVW------DLRTGECVQTLSGhTNSVTSL 267

                       170       180
                ....*....|....*....|..
gi 61743971 169 SWNPSSSRahspmIAVGSDDSS 190
Cdd:cd00200 268 AWSPDGKR-----LASGSADGT 284
WD40 COG2319
WD40 repeat [General function prediction only];
9-146 1.21e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.95  E-value: 1.21e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971   9 ADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDkseSGDWHCTASWKTHSGSVWRVTWaHPEfGQVLASCSFDRTAAVWEE 88
Cdd:COG2319 285 TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD---LATGKLLRTLTGHTGAVRSVAF-SPD-GKTLASGSDDGTVRLWDL 359

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 61743971  89 IVGESNDKLRGQSHWvkrttlvdsrtsVTDVKFAPKhmGLMLATCSADGIVRIYEAPD 146
Cdd:COG2319 360 ATGELLRTLTGHTGA------------VTSVAFSPD--GRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
97-328 7.71e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.98  E-value: 7.71e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971  97 LRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSR 176
Cdd:COG2319   8 ALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743971 177 AHSPMIAVGSDDSSpnamakVQIFEYNENTRkyakAETLMTVTDPVHDIAFAPNlGRsfhILAIATKD--VRIFTLKpvr 254
Cdd:COG2319  88 PDGRLLASASADGT------VRLWDLATGLL----LRTLTGHTGAVRSVAFSPD-GK---TLASGSADgtVRLWDLA--- 150

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 61743971 255 keltsSGGPtkfeihiVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKAnymDNWKCTGILKGNGSPVNG 328
Cdd:COG2319 151 -----TGKL-------LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL---ATGKLLRTLTGHTGAVRS 209
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 271-306 3.44e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 3.44e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 61743971    271 VAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWK 306
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 11-40 1.16e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.16e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 61743971     11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWD 40
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
271-305 1.47e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.47e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 61743971   271 VAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLW 305
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
11-40 3.48e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 3.48e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 61743971    11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWD 40
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 46-87 1.43e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.43e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 61743971     46 DWHCTASWKTHSGSVWRVTWAHpeFGQVLASCSFDRTAAVWE 87
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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