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Conserved domains on  [gi|61743926|ref|NP_001013433|]
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F-box/WD repeat-containing protein 7 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
193-574 2.24e-94

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 294.90  E-value: 2.24e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926 193 WRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGFIHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITC-LQF 271
Cdd:COG2319   9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVaFSP 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926 272 CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWS---SqmRD-NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVR 347
Cdd:COG2319  89 DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSvafS--PDgKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVT 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926 348 CMHLH--EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHT 423
Cdd:COG2319 167 SVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKLLASGSADGTVRLWDLATGKLLRTLTGHS 246

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926 424 NRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTL 499
Cdd:COG2319 247 GSVRSVAFspDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGKLLASGSDDGTVRLWDLATGKLLRTL 326

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 61743926 500 QGpnkHQSAVTCLQF--NKNFVITSSDDGTVKLWDLKTGEFIRNLvtlesGGSGGVVWRIRASNTKLVCAVGSRNGT 574
Cdd:COG2319 327 TG---HTGAVRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTL-----TGHTGAVTSVAFSPDGRTLASGSADGT 395
F-box_FBXW7 cd22133
F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, ...
 146-204 3.09e-39

F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, also called Archipelago homolog (Ago), F-box and WD-40 domain-containing protein 7, F-box protein FBX30, SEL-10, or Cdc4, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438905  Cd Length: 59  Bit Score: 137.56  E-value: 3.09e-39
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 61743926 146 QVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 204
Cdd:cd22133   1 QVRHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 59
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
193-574 2.24e-94

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 294.90  E-value: 2.24e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926 193 WRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGFIHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITC-LQF 271
Cdd:COG2319   9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVaFSP 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926 272 CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWS---SqmRD-NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVR 347
Cdd:COG2319  89 DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSvafS--PDgKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVT 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926 348 CMHLH--EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHT 423
Cdd:COG2319 167 SVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKLLASGSADGTVRLWDLATGKLLRTLTGHS 246

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926 424 NRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTL 499
Cdd:COG2319 247 GSVRSVAFspDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGKLLASGSDDGTVRLWDLATGKLLRTL 326

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 61743926 500 QGpnkHQSAVTCLQF--NKNFVITSSDDGTVKLWDLKTGEFIRNLvtlesGGSGGVVWRIRASNTKLVCAVGSRNGT 574
Cdd:COG2319 327 TG---HTGAVRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTL-----TGHTGAVTSVAFSPDGRTLASGSADGT 395
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 256-532 1.55e-92

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 286.15  E-value: 1.55e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926 256 KVLKGHDDhVITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV----WSSQmrDNIIISGSTDRTLKVWN 329
Cdd:cd00200   3 RTLKGHTG-GVTCVAFspDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVrdvaASAD--GTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926 330 AETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMV 405
Cdd:cd00200  80 LETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFspDGTFVASSSQDGTI 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926 406 KVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQ-SLTSGMELKDN-ILVSGNA 481
Cdd:cd00200 160 KLWDLRTGKCVATLTGHTGEVNSVAFspDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEnGVNSVAFSPDGyLLASGSE 239

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 61743926 482 DSTVKIWDIKTGQCLQTLQGpnkHQSAVTCLQF--NKNFVITSSDDGTVKLWD 532
Cdd:cd00200 240 DGTIRVWDLRTGECVQTLSG---HTNSVTSLAWspDGKRLASGSADGTIRIWD 289
F-box_FBXW7 cd22133
F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, ...
 146-204 3.09e-39

F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, also called Archipelago homolog (Ago), F-box and WD-40 domain-containing protein 7, F-box protein FBX30, SEL-10, or Cdc4, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438905  Cd Length: 59  Bit Score: 137.56  E-value: 3.09e-39
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 61743926 146 QVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 204
Cdd:cd22133   1 QVRHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 59
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 163-207 1.08e-14

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 68.28  E-value: 1.08e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 61743926   163 ISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKC 207
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 274-443 1.25e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 61.26  E-value: 1.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926  274 NRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWS---SQMRDNIIISGSTDRTLKVWNAETGECIHTLyGHTSTVRCMH 350
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSidySSADPTLLASGSDDGSVKLWSINQGVSIGTI-KTKANICCVQ 624

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926  351 LHE---KRVVSGSRDATLRVWDIETGQC-LHVLMGHVAAVRCVQY-DGRRVVSGAYDFMVKVWDPE------TETCLHTL 419
Cdd:PLN00181 625 FPSesgRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFvDSSTLVSSSTDNTLKLWDLSmsisgiNETPLHSF 704

                        170       180
                 ....*....|....*....|....
gi 61743926  420 QGHTNrvySLQFDGIHVVSGSLDT 443
Cdd:PLN00181 705 MGHTN---VKNFVGLSVSDGYIAT 725
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 492-532 1.74e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.74e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 61743926    492 TGQCLQTLQGpnkHQSAVTCLQFNKN--FVITSSDDGTVKLWD 532
Cdd:smart00320   1 SGELLKTLKG---HTGPVTSVAFSPDgkYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
414-449 2.04e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 2.04e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 61743926   414 TCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 449
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
FBOX smart00256
A Receptor for Ubiquitination Targets;
166-206 2.24e-06

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 44.35  E-value: 2.24e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 61743926    166 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREK 206
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
193-574 2.24e-94

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 294.90  E-value: 2.24e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926 193 WRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGFIHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITC-LQF 271
Cdd:COG2319   9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVaFSP 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926 272 CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWS---SqmRD-NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVR 347
Cdd:COG2319  89 DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSvafS--PDgKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVT 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926 348 CMHLH--EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHT 423
Cdd:COG2319 167 SVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKLLASGSADGTVRLWDLATGKLLRTLTGHS 246

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926 424 NRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTL 499
Cdd:COG2319 247 GSVRSVAFspDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGKLLASGSDDGTVRLWDLATGKLLRTL 326

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 61743926 500 QGpnkHQSAVTCLQF--NKNFVITSSDDGTVKLWDLKTGEFIRNLvtlesGGSGGVVWRIRASNTKLVCAVGSRNGT 574
Cdd:COG2319 327 TG---HTGAVRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTL-----TGHTGAVTSVAFSPDGRTLASGSADGT 395
WD40 COG2319
WD40 repeat [General function prediction only];
247-535 6.89e-94

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 293.74  E-value: 6.89e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926 247 WRRGELKSPKVLKGHDDHViTCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTD 322
Cdd:COG2319 105 WDLATGLLLRTLTGHTGAV-RSVAFspDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDgkLLASGSDD 183

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926 323 RTLKVWNAETGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVS 398
Cdd:COG2319 184 GTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFspDGRLLAS 263

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926 399 GAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL--KDN 474
Cdd:COG2319 264 GSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGK 343

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 61743926 475 ILVSGNADSTVKIWDIKTGQCLQTLQGpnkHQSAVTCLQFNKN--FVITSSDDGTVKLWDLKT 535
Cdd:COG2319 344 TLASGSDDGTVRLWDLATGELLRTLTG---HTGAVTSVAFSPDgrTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 256-532 1.55e-92

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 286.15  E-value: 1.55e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926 256 KVLKGHDDhVITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV----WSSQmrDNIIISGSTDRTLKVWN 329
Cdd:cd00200   3 RTLKGHTG-GVTCVAFspDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVrdvaASAD--GTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926 330 AETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMV 405
Cdd:cd00200  80 LETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFspDGTFVASSSQDGTI 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926 406 KVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQ-SLTSGMELKDN-ILVSGNA 481
Cdd:cd00200 160 KLWDLRTGKCVATLTGHTGEVNSVAFspDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEnGVNSVAFSPDGyLLASGSE 239

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 61743926 482 DSTVKIWDIKTGQCLQTLQGpnkHQSAVTCLQF--NKNFVITSSDDGTVKLWD 532
Cdd:cd00200 240 DGTIRVWDLRTGECVQTLSG---HTNSVTSLAWspDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 335-574 4.80e-63

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 209.11  E-value: 4.80e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926 335 CIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDP 410
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPdgKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926 411 ETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETGNCIHTLTGHQSltSGMELK----DNILVSGNADST 484
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTD--WVNSVAfspdGTFVASSSQDGT 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926 485 VKIWDIKTGQCLQTLQGpnkHQSAVTCLQF--NKNFVITSSDDGTVKLWDLKTGEFIRNLVtlesgGSGGVVWRIRASNT 562
Cdd:cd00200 159 IKLWDLRTGKCVATLTG---HTGEVNSVAFspDGEKLLSSSSDGTIKLWDLSTGKCLGTLR-----GHENGVNSVAFSPD 230

                       250
                ....*....|..
gi 61743926 563 KLVCAVGSRNGT 574
Cdd:cd00200 231 GYLLASGSEDGT 242
F-box_FBXW7 cd22133
F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, ...
 146-204 3.09e-39

F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, also called Archipelago homolog (Ago), F-box and WD-40 domain-containing protein 7, F-box protein FBX30, SEL-10, or Cdc4, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438905  Cd Length: 59  Bit Score: 137.56  E-value: 3.09e-39
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 61743926 146 QVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 204
Cdd:cd22133   1 QVRHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 59
WD40 COG2319
WD40 repeat [General function prediction only];
392-574 4.00e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.83  E-value: 4.00e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926 392 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGM 469
Cdd:COG2319   5 DGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAAspDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSV 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926 470 ELK--DNILVSGNADSTVKIWDIKTGQCLQTLQGpnkHQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFIRNLVtl 545
Cdd:COG2319  85 AFSpdGRLLASASADGTVRLWDLATGLLLRTLTG---HTGAVRSVAFSPDgkTLASGSADGTVRLWDLATGKLLRTLT-- 159

                       170       180       190
                ....*....|....*....|....*....|
gi 61743926 546 esgGSGGVVWRIRAS-NTKLVcAVGSRNGT 574
Cdd:COG2319 160 ---GHSGAVTSVAFSpDGKLL-ASGSDDGT 185
F-box_DdgacFF-like cd22148
F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) ...
 162-205 4.01e-15

F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) and similar proteins; DdgacFF, also called GTPase activating factor for raC protein FF, is a Rho GTPase-activating protein involved in the signal transduction pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438919  Cd Length: 44  Bit Score: 69.23  E-value: 4.01e-15
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 61743926 162 FISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWRE 205
Cdd:cd22148   1 FISLLPEHLALKILSYLSPKELLIASQVSKTWRRLASSNELWKA 44
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 163-207 1.08e-14

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 68.28  E-value: 1.08e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 61743926   163 ISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKC 207
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
F-box_FBXO16-like cd22094
F-box domain found in F-box only protein 16 (FBXO16), epithelial cell-transforming sequence 2 ...
 161-207 1.95e-13

F-box domain found in F-box only protein 16 (FBXO16), epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; This family includes FBXO16 and ECT2L. FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438866  Cd Length: 49  Bit Score: 64.78  E-value: 1.95e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 61743926 161 DFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKC 207
Cdd:cd22094   1 DFTRVLPRFLSLYIFSYLDPRSLCRAAQVSWYWKFLCESDELWLPKC 47
F-box_ECT2L cd22173
F-box domain found in epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and ...
 161-211 2.33e-13

F-box domain found in epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438944  Cd Length: 52  Bit Score: 64.74  E-value: 2.33e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 61743926 161 DFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEG 211
Cdd:cd22173   1 DFTTVLPRFLSLYIFSFLDPRSLCRAAQVSWHWKFLAEQDCLWMPKCVKFG 51
F-box_SpPof1-like cd22147
F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar ...
 162-207 1.51e-12

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438918  Cd Length: 46  Bit Score: 61.94  E-value: 1.51e-12
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 61743926 162 FISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKC 207
Cdd:cd22147   1 FLSALPVELSLKILSYLDAKSLCRAAQVSKKWRNLADDDELWKRMC 46
F-box_FBXO16 cd22172
F-box domain found in F-box only protein 16 (FBXO16) and similar proteins; FBXO16, also called ...
 158-207 5.13e-12

F-box domain found in F-box only protein 16 (FBXO16) and similar proteins; FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438943  Cd Length: 55  Bit Score: 60.76  E-value: 5.13e-12
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 61743926 158 FQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKC 207
Cdd:cd22172   1 EHIDFTRVLPRVLSLYIFSFLDPRSLCRCAQVCWYWKYLTELDQLWMPKC 50
F-box_FBXO4 cd22085
F-box domain found in F-box only protein 4 (FBXO4) and similar proteins; FBXO4, also called ...
 166-204 3.55e-10

F-box domain found in F-box only protein 4 (FBXO4) and similar proteins; FBXO4, also called FBX4, is a specific substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that catalyzes the ubiquitination and subsequent degradation of cyclin D1 and Trx1. It recognizes TERF1 and promotes its ubiquitination together with UBE2D1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438857  Cd Length: 50  Bit Score: 55.49  E-value: 3.55e-10
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 61743926 166 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 204
Cdd:cd22085   6 LPIDLQLYILSFLSPHDLCQLGLTSHYWHTLVRDPLLWR 44
F-box_FBXW5 cd22132
F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, ...
 164-205 4.59e-10

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438904 [Multi-domain]  Cd Length: 46  Bit Score: 54.93  E-value: 4.59e-10
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 61743926 164 SLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWRE 205
Cdd:cd22132   2 PLLPDSLLLHIFSYLSPKDLLAAGQVCKQWYRVSRDEFLWKE 43
F-box_FBXW8 cd22134
F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, ...
 166-207 1.05e-09

F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, also called F-box and WD-40 domain-containing protein 8, or F-box only protein 29 (FBXO29), is the substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as GORASP1, IRS1, MAP4K1/HPK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438906  Cd Length: 48  Bit Score: 54.30  E-value: 1.05e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 61743926 166 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKC 207
Cdd:cd22134   7 LPRELALKIFQYLSVTDLCRCAQVSKSWKSLAEDELLWYRIC 48
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 274-443 1.25e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 61.26  E-value: 1.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926  274 NRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWS---SQMRDNIIISGSTDRTLKVWNAETGECIHTLyGHTSTVRCMH 350
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSidySSADPTLLASGSDDGSVKLWSINQGVSIGTI-KTKANICCVQ 624

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926  351 LHE---KRVVSGSRDATLRVWDIETGQC-LHVLMGHVAAVRCVQY-DGRRVVSGAYDFMVKVWDPE------TETCLHTL 419
Cdd:PLN00181 625 FPSesgRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFvDSSTLVSSSTDNTLKLWDLSmsisgiNETPLHSF 704

                        170       180
                 ....*....|....*....|....
gi 61743926  420 QGHTNrvySLQFDGIHVVSGSLDT 443
Cdd:PLN00181 705 MGHTN---VKNFVGLSVSDGYIAT 725
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 391-533 1.62e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 60.87  E-value: 1.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926  391 YDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF---DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTS 467
Cdd:PLN00181 543 YIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYssaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICC 622

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926  468 GMELKDN--ILVSGNADSTVKIWDIKTGQC-LQTLQGpnkHQSAVTCLQF-NKNFVITSSDDGTVKLWDL 533
Cdd:PLN00181 623 VQFPSESgrSLAFGSADHKVYYYDLRNPKLpLCTMIG---HSKTVSYVRFvDSSTLVSSSTDNTLKLWDL 689
F-box_unchar cd22139
F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 ...
 165-207 3.68e-09

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 (FBXO3); This subfamily corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 3 (FBXO3). FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, that mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438911  Cd Length: 45  Bit Score: 52.63  E-value: 3.68e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 61743926 165 LLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKC 207
Cdd:cd22139   3 CLPDELWLHIFSFLSPKDLCQVALVCRRFNRLASDESLWKQIC 45
F-box_FBXW12 cd22137
F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; ...
 166-207 4.02e-09

F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; FBXW12, also called F-box and WD-40 domain-containing protein 12, or F-box only protein 35 (FBXO35), is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It functions as an epithelial growth suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438909  Cd Length: 44  Bit Score: 52.38  E-value: 4.02e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 61743926 166 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKC 207
Cdd:cd22137   3 LPDLPMLRIFSFLDAFSLLQAAQVNKQWNKVADSDYLWRNLC 44
F-box_FBXO48 cd22113
F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called ...
 163-207 4.99e-09

F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called FBX48, is one of the paralogs of the F-box only protein 7 (FBXO7), which is the causative gene for PARK15 (also known as Parkinsonian-pyramidal disease, PPD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438885  Cd Length: 46  Bit Score: 52.32  E-value: 4.99e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 61743926 163 ISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDN-LLWREKC 207
Cdd:cd22113   1 IELLPPEMSLRIFSQLDVQSLCRASQTCKTWNDLIENSdYLWRPHC 46
F-box_FBXL13 cd22124
F-box domain found in F-box/LRR-repeat protein 13 (FBXL13) and similar proteins; FBXL13, also ...
 163-203 1.06e-08

F-box domain found in F-box/LRR-repeat protein 13 (FBXL13) and similar proteins; FBXL13, also called F-box and leucine-rich repeat protein 13, or dynein regulatory complex subunit 6, is a component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. It is also the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438896  Cd Length: 42  Bit Score: 51.18  E-value: 1.06e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 61743926 163 ISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLW 203
Cdd:cd22124   1 ISLLPRKAALKIFSYLDLRDLARCAQVCRSWKVITQSSSLW 41
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 164-198 2.22e-08

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 50.14  E-value: 2.22e-08
                        10        20        30
                ....*....|....*....|....*....|....*
gi 61743926 164 SLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAE 198
Cdd:cd09917   1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
WD40 COG2319
WD40 repeat [General function prediction only];
428-574 2.77e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.07  E-value: 2.77e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926 428 SLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCLQTLQGpnkH 505
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASpdGARLAAGAGDLTLLLLDAAAGALLATLLG---H 77

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 61743926 506 QSAVTCLQF--NKNFVITSSDDGTVKLWDLKTGEFIRNLVtlesgGSGGVVWRIRAS-NTKLVcAVGSRNGT 574
Cdd:COG2319  78 TAAVLSVAFspDGRLLASASADGTVRLWDLATGLLLRTLT-----GHTGAVRSVAFSpDGKTL-ASGSADGT 143
F-box_FBXO7 cd22087
F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called ...
 165-207 5.93e-08

F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called FBX7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes BIRC2 and DLGAP5. FBXO7 plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. It promotes MFN1 ubiquitination. FBXO7 acts as a cell cycle regulator by enhancing cyclin D/cyclin-dependent kinase 6 (Cdk6) complex formation and stabilizing levels of p27, a cyclin-dependent kinase inhibitor. Mutations in the FBXO7 (PARK15) gene have been implicated in a juvenile form of parkinsonism called parkinsonian pyramidal syndrome (PPS), characterized by Parkinsonian symptoms and pyramidal tract signs. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438859  Cd Length: 45  Bit Score: 49.22  E-value: 5.93e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 61743926 165 LLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKC 207
Cdd:cd22087   3 ALPPEIKLRILSLLDVRSLLSLSQVCRDLNSATNDQLLWRFLL 45
F-box_FBXL4 cd22117
F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also ...
 163-205 1.16e-07

F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also called F-box and leucine-rich repeat protein 4, or F-box protein FBL4/FBL5, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It serves as a clock output molecule that regulates sleep through promotion of rhythmic degradation of the GABA(A) receptor. Biallelic pathogenic variants in FBXL4 are associated with an encephalopathic mtDNA maintenance defect syndrome that is a multi-system disease characterized by lactic acidemia, developmental delay, and hypotonia. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438889  Cd Length: 47  Bit Score: 48.39  E-value: 1.16e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 61743926 163 ISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWRE 205
Cdd:cd22117   1 FDLLPYELIQLILSYLDLPSLCRLSQTCKLFRKHCYDPLLWKE 43
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 492-532 1.74e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.74e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 61743926    492 TGQCLQTLQGpnkHQSAVTCLQFNKN--FVITSSDDGTVKLWD 532
Cdd:smart00320   1 SGELLKTLKG---HTGPVTSVAFSPDgkYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
414-449 2.04e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 2.04e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 61743926   414 TCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 449
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 412-449 2.31e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 2.31e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 61743926    412 TETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 449
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
F-box_FBXL5 cd22118
F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also ...
 163-203 2.51e-07

F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also called F-box and leucine-rich repeat protein 5, F-box protein FBL4/FBL5, or p45SKP2-like protein, is the substrate-recognition component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438890  Cd Length: 41  Bit Score: 47.33  E-value: 2.51e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 61743926 163 ISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLW 203
Cdd:cd22118   1 ISSLPPEIMLKIFSYLNPQDLCRCAQVCTKWSQLARDGSLW 41
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 163-204 3.04e-07

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 47.15  E-value: 3.04e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 61743926   163 ISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 204
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWK 42
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 332-369 3.49e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 3.49e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 61743926    332 TGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWD 369
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSpdGKYLASGSDDGTIKLWD 40
F-box_FBXL2-like cd22115
F-box domain found in F-box/LRR-repeat protein 2 (FBXL2), F-box/LRR-repeat protein 20 (FBXL20) ...
 166-204 4.15e-07

F-box domain found in F-box/LRR-repeat protein 2 (FBXL2), F-box/LRR-repeat protein 20 (FBXL20) and similar proteins; The family includes FBXL2 and FBXL30. FBXL2, also called F-box and leucine-rich repeat protein 2, or F-box protein FBL2/FBL3, is a calcium-activated substrate-recognition component of an SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. FBXL20, also called SCRAPPER, F-box and leucine-rich repeat protein 20, or F-box/LRR-repeat protein 2-like, is a component of a synapse-localized SCF-type E3 ubiquitin ligase which regulates neural transmission. It is widely expressed in the central nervous system and plays an important role in the ubiquitin-dependent degradation of regulating synaptic membrane exocytosis 1 (RIM1), which is an important factor in the release of synaptic vesicles. It may also mediate the ubiquitin degradation of E-cadherin resulting in an increased invasive ability of malignant cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438887  Cd Length: 45  Bit Score: 46.64  E-value: 4.15e-07
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 61743926 166 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 204
Cdd:cd22115   7 LPKELLLRIFSFLDVVTLCRCAQVSKYWNVLALDGSNWQ 45
F-box_FBXO3 cd22084
F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called ...
 163-209 4.44e-07

F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438856  Cd Length: 49  Bit Score: 46.87  E-value: 4.44e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 61743926 163 ISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKE 209
Cdd:cd22084   1 LDDLPSDPLLNILSFLDYRDLISCSQVCRRLNQLCSHDPLWKRLCKK 47
WD40 pfam00400
WD domain, G-beta repeat;
493-532 5.45e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 5.45e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 61743926   493 GQCLQTLQGpnkHQSAVTCLQFNKN--FVITSSDDGTVKLWD 532
Cdd:pfam00400   1 GKLLKTLEG---HTGSVTSLAFSPDgkLLASGSDDGTVKVWD 39
F-box_FBXL12 cd22123
F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also ...
 163-204 6.84e-07

F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also called F-box and leucine-rich repeat protein 12, or F-box protein FBL12, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the polyubiquitination and proteasomal degradation of calcium/calmodulin dependent protein kinase I (CAMK1) leading to disruption of cyclin D1/CDK4 complex assembly, which results in G1 cell cycle arrest in lung epithelia. It regulates T-cell differentiation in a cell-autonomous manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438895  Cd Length: 42  Bit Score: 46.19  E-value: 6.84e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 61743926 163 ISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 204
Cdd:cd22123   1 LDQLPENVLLEILSYLPVRDLLRISRVCKRWRRLVYDKTLWR 42
F-box_AtSKIP31-like cd22166
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 31 (AtSKIP31) and similar ...
 166-204 7.60e-07

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 31 (AtSKIP31) and similar proteins; AtSKIP31, also called F-box protein SKIP31, is a component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438937  Cd Length: 46  Bit Score: 45.91  E-value: 7.60e-07
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 61743926 166 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 204
Cdd:cd22166   4 LPPELFRHILKFLSPEDLTSCATVCRFLRGAASDESLWR 42
WD40 pfam00400
WD domain, G-beta repeat;
333-369 8.14e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 8.14e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 61743926   333 GECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWD 369
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSpdGKLLASGSDDGTVKVWD 39
F-box_FBXO41 cd22109
F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called ...
 163-207 8.84e-07

F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438881  Cd Length: 47  Bit Score: 45.78  E-value: 8.84e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 61743926 163 ISLLPKELALY-VLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKC 207
Cdd:cd22109   2 LESLRRRDALFcVFSYLDTKSLLRCAEVCREWRDVSRHPALWQRVC 47
F-box_FBXW2 cd22131
F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, ...
 161-193 1.12e-06

F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, also called F-box and WD-40 domain-containing protein 2, or protein MD6, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a tumor suppressor by promoting SKP2 degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438903  Cd Length: 40  Bit Score: 45.40  E-value: 1.12e-06
                        10        20        30
                ....*....|....*....|....*....|...
gi 61743926 161 DFISLLPKELALYVLSFLEPKDLLQAAQTCRYW 193
Cdd:cd22131   1 DFLKLLPLELSFYLLSFLDPESLLTCCLVSKQW 33
F-box_FBXL1 cd22114
F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also ...
 164-203 1.38e-06

F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also called S-phase kinase-associated protein 2, cyclin-A/CDK2-associated protein p45, F-box protein Skp2, or p45skp2, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. It specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438886  Cd Length: 41  Bit Score: 45.09  E-value: 1.38e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 61743926 164 SLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLW 203
Cdd:cd22114   2 DSLPDELLLGIFSCLCLPDLLKVSQVCKRWYRLASDESLW 41
F-box_FBXW1 cd22130
F-box domain found in F-box/WD repeat-containing proteins, FBXW1A, FBXW1B and similar proteins; ...
 159-205 1.70e-06

F-box domain found in F-box/WD repeat-containing proteins, FBXW1A, FBXW1B and similar proteins; FBXW1A, also called E3RSIkappaB, epididymis tissue protein Li 2a, F-box and WD repeats protein beta-TrCP, or pIkappaBalpha-E3 receptor subunit, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CTNNB1, NFKBIA, NFKBIB and NFKBIE, as well as phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. FBXW1B, also called F-box/WD repeat-containing protein 11 (FBXW11), F-box and WD repeats protein beta-TrCP2, or homologous to Slimb protein (HOS), is the substrate-recognition component of an SCF E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as IFNAR1, CEP68 and CDC25A, as well as phosphorylated CTNNB1, NFKBIA, PER1 and PER2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438902  Cd Length: 51  Bit Score: 45.16  E-value: 1.70e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 61743926 159 QRDFISLLPKE----LALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWRE 205
Cdd:cd22130   1 QRDFISALPAKgldhIAENILSYLDAKSLCAAELVCKEWYRVIADGMLWKK 51
FBOX smart00256
A Receptor for Ubiquitination Targets;
166-206 2.24e-06

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 44.35  E-value: 2.24e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 61743926    166 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREK 206
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 372-409 2.45e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 2.45e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 61743926    372 TGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWD 409
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
F-box_FBXW1B cd22183
F-box domain found in F-box/WD repeat-containing protein 1B (FBXW1B) and similar proteins; ...
 159-205 2.67e-06

F-box domain found in F-box/WD repeat-containing protein 1B (FBXW1B) and similar proteins; FBXW1B, also called F-box/WD repeat-containing protein 11 (FBXW11), F-box and WD repeats protein beta-TrCP2, or homologous to Slimb protein (HOS), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as IFNAR1, CEP68 and CDC25A, as well as phosphorylated CTNNB1, NFKBIA, PER1 and PER2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438954  Cd Length: 51  Bit Score: 44.51  E-value: 2.67e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 61743926 159 QRDFISLLPKE----LALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWRE 205
Cdd:cd22183   1 QRDFITALPAKgldhIAENILSYLDAESLCAAELVCKEWQRVISEGMLWKK 51
F-box_AtARP8-like cd22156
F-box domain found in Arabidopsis thaliana actin-related protein 8 (AtARP8) and similar ...
 166-203 2.75e-06

F-box domain found in Arabidopsis thaliana actin-related protein 8 (AtARP8) and similar proteins; AtARP8, also called F-box protein ARP8, is an F-box protein localized to the nucleolus in Arabidopsis. Unlike other plant nuclear actin-related proteins (ARPs), ARP8 is unique in having an F-box domain and an actin homology domain. It may play a role in nucleolar functions. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438927  Cd Length: 45  Bit Score: 44.29  E-value: 2.75e-06
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 61743926 166 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLW 203
Cdd:cd22156   5 LPEDVLMQILRLLGPKDAAKLCLVCKSWRYLVSDNRLW 42
F-box_AtGID2-like cd22151
F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, ...
 164-207 3.18e-06

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438922  Cd Length: 44  Bit Score: 44.23  E-value: 3.18e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 61743926 164 SLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKC 207
Cdd:cd22151   1 RKLPDDLLQEIFKRLDPKSLARAACVCRRWRAAARSESLWENAC 44
F-box_FBXO31 cd22102
F-box domain found in F-box only protein 31 (FBXO31) and similar proteins; FBXO31, also called ...
 166-210 3.48e-06

F-box domain found in F-box only protein 31 (FBXO31) and similar proteins; FBXO31, also called FBX31, or FBXO14, is a component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. It specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. FBXO31 may act as a tumor suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438874  Cd Length: 48  Bit Score: 44.34  E-value: 3.48e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 61743926 166 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEE 210
Cdd:cd22102   4 LPPELLVEIFSSLPGTDLPSLAQVCKKFREILNTDTIWQRRCKEE 48
F-box_FBXO17-like cd22169
F-box domain found in F-box only protein 17 (FBXO17), F-box only protein 27 (FBXO27) and ...
 163-207 4.64e-06

F-box domain found in F-box only protein 17 (FBXO17), F-box only protein 27 (FBXO27) and similar proteins; This subfamily includes FBXO17 and FBXO27. FBXO17 is also called FBX17, F-box only protein 26 (FBX26/FBXO26), or FBG4, while FBXO27 is also called FBX27, or F-box/G-domain protein 5. FBXO17 and FBXO27 are the substrate-recognition components of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. They can recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. FBXO17 also recognizes sulfated glycans but does not bind high-mannose glycoproteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438940  Cd Length: 48  Bit Score: 43.95  E-value: 4.64e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 61743926 163 ISLLPKELALYVLSFLEPKDLLQAA-QTCRYWRILAEDNLLWREKC 207
Cdd:cd22169   1 LSLLPEELLLLVLSHVPARTLVTRCrLVCRDWRDLVDGPTLWKLKC 46
PTZ00421 PTZ00421
coronin; Provisional
 381-534 4.97e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.12  E-value: 4.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926  381 GHVAAVRCVQYDGRRVVSGAYDFMVKVWD-PE---TETCLHT---LQGHTNRVYSLQF----DGIhVVSGSLDTSIRVWD 449
Cdd:PTZ00421  76 GPIIDVAFNPFDPQKLFTASEDGTIMGWGiPEeglTQNISDPivhLQGHTKKVGIVSFhpsaMNV-LASAGADMVVNVWD 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926  450 VETGNCIHTLTGHQSLTSGME--LKDNILVSGNADSTVKIWDIKTGQCLQTLQG--PNKHQSAVTCLQfnKNFVIT---- 521
Cdd:PTZ00421 155 VERGKAVEVIKCHSDQITSLEwnLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAhaSAKSQRCLWAKR--KDLIITlgcs 232

                        170
                 ....*....|...
gi 61743926  522 SSDDGTVKLWDLK 534
Cdd:PTZ00421 233 KSQQRQIMLWDTR 245
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 292-329 9.05e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 9.05e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 61743926    292 TGKCLRTLVGHTGGVWSSQM--RDNIIISGSTDRTLKVWN 329
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
F-box_FBXO15 cd22093
F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called ...
 163-208 9.61e-06

F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called FBX15, has a novel dual molecular function by controlling transcriptional repression and being part of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligases, which is essential for stress response, gliotoxin production and virulence in the opportunistic human pathogen Aspergillus fumigatus. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438865  Cd Length: 46  Bit Score: 43.01  E-value: 9.61e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 61743926 163 ISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCK 208
Cdd:cd22093   1 IERLPSEILLKILSYLDASSLLCISCVNKLFYQLANDNALWRKLYS 46
WD40 pfam00400
WD domain, G-beta repeat;
373-409 1.15e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.15e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 61743926   373 GQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWD 409
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
F-box_AtSKIP22-like cd22165
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 22 (AtSKIP22) and similar ...
 165-207 1.26e-05

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 22 (AtSKIP22) and similar proteins; AtSKIP22, also called F-box protein SKIP22, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438936  Cd Length: 46  Bit Score: 42.65  E-value: 1.26e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 61743926 165 LLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKC 207
Cdd:cd22165   4 RLPTELKLKILELLPGVDLARMACVCSELRFLASNDDLWKQKF 46
F-box_FBXO11 cd22091
F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called ...
 166-204 1.58e-05

F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called FBX11, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438863  Cd Length: 45  Bit Score: 42.41  E-value: 1.58e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 61743926 166 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 204
Cdd:cd22091   4 LPDEVLLKIFSYLLEQDLCRAAQVCKRFNTLANDPELWK 42
F-box_FBXO8 cd22088
F-box domain found in F-box only protein 8 (FBXO8) and similar proteins; FBXO8, also called ...
 163-208 2.30e-05

F-box domain found in F-box only protein 8 (FBXO8) and similar proteins; FBXO8, also called FBX8, or F-box/SEC7 protein FBS, is a novel component of F-box proteins which contains an F-box domain and a putative Sec7 domain. FBX8 was originally identified as a Skp1-binding protein. It is involved in the ubiquitin-dependent proteolytic pathway. It acts as a metastasis suppressor that functions through mTOR signaling pathway. FBXO8 may promote the activation of ADP-ribosylation factor (ARF) through replacement of GDP with GTP. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438860  Cd Length: 46  Bit Score: 41.93  E-value: 2.30e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 61743926 163 ISLLPKELALYVLSFLEPKDLLQAAqtCrYWRILAEDNLLWREKCK 208
Cdd:cd22088   4 LEELPPELSLTVLSHLNATDLCLAS--C-VWQDLANDELLWQGLCR 46
WD40 pfam00400
WD domain, G-beta repeat;
293-329 2.76e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 2.76e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 61743926   293 GKCLRTLVGHTGGVWS--SQMRDNIIISGSTDRTLKVWN 329
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSlaFSPDGKLLASGSDDGTVKVWD 39
F-box_FBXO33 cd22104
F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called ...
 164-194 3.02e-05

F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called FBX33, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It exerts similar functions as F-box involved in polyQ pathogenesis (FipoQ) in modulating the ubiquitination and solubility of expanded SCA3-polyQ proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438876  Cd Length: 48  Bit Score: 41.47  E-value: 3.02e-05
                        10        20        30
                ....*....|....*....|....*....|.
gi 61743926 164 SLLPKELALYVLSFLEPKDLLQAAQTCRYWR 194
Cdd:cd22104   2 ANLPSVVLVHIFSYLPPRDRLRASSTCRRWR 32
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 256-289 5.63e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 5.63e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 61743926    256 KVLKGHDDHViTCLQFC--GNRIVSGSDDNTLKVWS 289
Cdd:smart00320   6 KTLKGHTGPV-TSVAFSpdGKYLASGSDDGTIKLWD 40
F-box_FBXO6-like cd22168
F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily ...
 163-211 6.06e-05

F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily includes FBXO6 and FBXO44. FBXO6, also called FBX6, F-box protein that recognizes sugar chains 2 (FBS2), or F-box/G-domain protein 2 (FBG2), is a substrate-recognition component of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. It is involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins, by recognizing and binding sugar chains on unfolded glycoproteins that are retro-translocated into the cytosol and promoting their ubiquitination and subsequent degradation. FBXO6 can recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. It also recognizes sulfated glycans. FBXO6 is involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. FBXO44, also called FBXO6A, FBX44, or F-box/G-domain protein 3 (FBG3), is a substrate-recognition component of an SCF-type E3 ubiquitin ligase complex. It interacts with SKP1 and CUL1. FBXO44 mediates BRCA1 ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438939 [Multi-domain]  Cd Length: 82  Bit Score: 41.89  E-value: 6.06e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 61743926 163 ISLLPKELALYVLSFLEPKDLLQAAQ-TCRYWRILAEDNLLWREKCKEEG 211
Cdd:cd22168   4 ISDLPEDVLLEILSLVPARDLILSCRlVCSRWRDLVDLPTLWKRKCQREG 53
F-box_FBXO36 cd22106
F-box domain found in F-box only protein 36 (FBXO36) and similar proteins; FBXO36, also called ...
 166-204 7.02e-05

F-box domain found in F-box only protein 36 (FBXO36) and similar proteins; FBXO36, also called FBX36, likely functions as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438878  Cd Length: 46  Bit Score: 40.25  E-value: 7.02e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 61743926 166 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 204
Cdd:cd22106   4 LPDKLLLYIISYLDLEDIARLSQTSKRFKKLCNSDELWE 42
F-box_ScMFB1-like cd22146
F-box domain found in Saccharomyces cerevisiae mitochondrial F-box protein MFB1 (ScMFB1) and ...
 166-204 7.52e-05

F-box domain found in Saccharomyces cerevisiae mitochondrial F-box protein MFB1 (ScMFB1) and similar proteins; ScMFB1 is a novel mitochondria-associated F-box protein that functions to increase mitochondrial connectivity in yeast. ScMFB1 acts as a key component of a Skp1-Cdc53/Cullin-F-box protein (SCF) ubiquitin ligase complex machinery that regulates mitochondrial dynamics throughout the yeast's entire life cycle. It interacts with Skp1p in an F-box-dependent manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438917  Cd Length: 42  Bit Score: 40.32  E-value: 7.52e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 61743926 166 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 204
Cdd:cd22146   4 LPLEILFEILIYLDIPDILNLSKTCRFLYVLLNDEILWR 42
F-box_unchar cd22138
F-box domain found in uncharacterized F-box protein group similar to F-box only protein 13 ...
 164-205 8.36e-05

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 13 (FBXO13); The family corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 13 (FBXO13). FBXO13, also called FBX13, or F-box/LRR-repeat protein 17 (FBL17), or F-box and leucine-rich repeat protein 17 (FBXL17), is the substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438910  Cd Length: 45  Bit Score: 40.01  E-value: 8.36e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 61743926 164 SLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWRE 205
Cdd:cd22138   2 QSLPVECQLKIFSFLSEVDKCLAATVCRSWSELIRSPRLWRT 43
F-box_FBXO24 cd22098
F-box domain found in F-box only protein 24 (FBXO24) and similar proteins; FBXO24, also called ...
 166-208 1.05e-04

F-box domain found in F-box only protein 24 (FBXO24) and similar proteins; FBXO24, also called FBX24, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It recognizes deacetylated nucleoside diphosphate kinase A (NDPK-A) to enhance its degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438870  Cd Length: 47  Bit Score: 40.00  E-value: 1.05e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 61743926 166 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCK 208
Cdd:cd22098   5 LPPEILDRIISFLPVKDIVSLGQTCRYFHEVCNSEAVWRRLCR 47
F-box_FBXO21 cd22096
F-box domain found in F-box only protein 21 (FBXO21) and similar proteins; FBXO21, also called ...
 163-206 1.70e-04

F-box domain found in F-box only protein 21 (FBXO21) and similar proteins; FBXO21, also called FBX21, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It facilitates Lys29-linkage and activation of ASK1 (apoptosis signal-regulating kinase 1) and promotes type I interferon production upon viral infection. It also polyubiquitylates EP300-interacting inhibitor of differentiation 1 (EID1) and is required for the efficient degradation of EID1 in both cycling and quiescent cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438868  Cd Length: 48  Bit Score: 39.60  E-value: 1.70e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 61743926 163 ISLLPKELALYVLS--FLEPKDLLQAAQTCRYWRILAEDNLLWREK 206
Cdd:cd22096   1 LLELPDELLEYILCsdNLDHHDIIRLSCTCRRLREVCQSGKVWREK 46
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
437-574 1.91e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.14  E-value: 1.91e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926 437 VSGSLDTSIRVWDVETGNCIHTLTGHQSlTSGMEL---KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNK-HQSAVTcl 512
Cdd:COG3391  84 VANSGSGRVSVIDLATGKVVATIPVGGG-PRGLAVdpdGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGpHGIAVD-- 160

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 61743926 513 QFNKNFVITSSDDGT----VKLWDLKTGEFIRNLVTlesggsGGVVWRIRAS-NTKLVCAVGSRNGT 574
Cdd:COG3391 161 PDGKRLYVANSGSNTvsviVSVIDTATGKVVATIPV------GGGPVGVAVSpDGRRLYVANRGSNT 221
F-box_FBXW10 cd22136
F-box domain found in F-box/WD repeat-containing protein 10 (FBXW10) and similar proteins; ...
 162-198 2.45e-04

F-box domain found in F-box/WD repeat-containing protein 10 (FBXW10) and similar proteins; FBXW10, also called F-box and WD-40 domain-containing protein 10, or ubiquitin ligase-specificity factor, is a probable substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Its overexpression leads to degradation of CBX5 and CBX1. FBXW10 is negatively regulated in transcription and expression levels by protein O-GlcNAcylation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438908  Cd Length: 40  Bit Score: 38.76  E-value: 2.45e-04
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 61743926 162 FISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAE 198
Cdd:cd22136   1 FIRCLPVHLSKYILSMLDKKSLNNCLCVSQHWRALTE 37
F-box_FBXO9 cd22089
F-box domain found in F-box only protein 9 (FBXO9) and similar proteins; FBXO9, also called ...
 162-207 2.51e-04

F-box domain found in F-box only protein 9 (FBXO9) and similar proteins; FBXO9, also called FBX9, cross-immune reaction antigen 1, renal carcinoma antigen NY-REN-57, or VCIA1, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. FBXO9 acts as an E3 ubiquitin ligase that regulates the stability and activity of peroxisome proliferator-activated receptor gamma (PPARgamma) through ubiquitination. It is also required for adipocyte differentiation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438861  Cd Length: 53  Bit Score: 39.13  E-value: 2.51e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 61743926 162 FISLLPKELALYVL----SFLEPKDLLQAAQTCRYWRILAEDNLLWREKC 207
Cdd:cd22089   2 HISALPSEILLYILrwvvSDLDLRSLEQLSLVCRKFYLLARDPSIWRLAC 51
WD40 pfam00400
WD domain, G-beta repeat;
256-289 2.62e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 2.62e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 61743926   256 KVLKGHDDHViTCLQFC--GNRIVSGSDDNTLKVWS 289
Cdd:pfam00400   5 KTLEGHTGSV-TSLAFSpdGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 355-539 2.69e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 43.73  E-value: 2.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926  355 RVVSGSRDATLRVWDIE----TGQCL-HV--LMGHVAAVRCVQY--DGRRVVSGA-YDFMVKVWDPETETCLHTLQGHTN 424
Cdd:PTZ00421  90 KLFTASEDGTIMGWGIPeeglTQNISdPIvhLQGHTKKVGIVSFhpSAMNVLASAgADMVVNVWDVERGKAVEVIKCHSD 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926  425 RVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL----KDNILVSGNADS---TVKIWDIKtgqc 495
Cdd:PTZ00421 170 QITSLEWnlDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQRCLwakrKDLIITLGCSKSqqrQIMLWDTR---- 245

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 61743926  496 lqTLQGP----NKHQSAVTCLQFNKN----FVITSSDDGTVKLWDLKTGEFI 539
Cdd:PTZ00421 246 --KMASPystvDLDQSSALFIPFFDEdtnlLYIGSKGEGNIRCFELMNERLT 295
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 419-544 4.42e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 43.15  E-value: 4.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926  419 LQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVET----GNCIH----TLTGHQSLTS---GMELKDNIlVSGNADSTV 485
Cdd:PLN00181 479 LLNSSNLVCAIGFDrdGEFFATAGVNKKIKIFECESiikdGRDIHypvvELASRSKLSGicwNSYIKSQV-ASSNFEGVV 557

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 61743926  486 KIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVT 544
Cdd:PLN00181 558 QVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT 616
F-box_FBXO42 cd22110
F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called ...
 163-199 5.09e-04

F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called FBX42, or just one F-box and Kelch domain-containing protein (JFK), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It specifically recognizes p53/TP53, promoting its ubiquitination and degradation. FBXO42 is also involved in the ubiquitin-proteasome system that may play a role in the pathogenesis of Parkinson's disease (PD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438882  Cd Length: 38  Bit Score: 37.70  E-value: 5.09e-04
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 61743926 163 ISLLPKELALYVLSFLEP-KDLLQAAQTCRYWRILAED 199
Cdd:cd22110   1 INDLPEEILEYILSYLSPyGDLKSAALVCKRWHRIIKG 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 452-489 5.30e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 5.30e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 61743926    452 TGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWD 489
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
F-box_FBXW1A cd22182
F-box domain found in F-box/WD repeat-containing protein 1A (FBXW1A) and similar proteins; ...
 158-205 6.86e-04

F-box domain found in F-box/WD repeat-containing protein 1A (FBXW1A) and similar proteins; FBXW1A, also called E3RSIkappaB, epididymis tissue protein Li 2a, F-box and WD repeats protein beta-TrCP, or pIkappaBalpha-E3 receptor subunit, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CTNNB1, NFKBIA, NFKBIB and NFKBIE, as well as phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438953  Cd Length: 60  Bit Score: 38.12  E-value: 6.86e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 61743926 158 FQRDFISLLP----KELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWRE 205
Cdd:cd22182   2 LQRDFITALParglDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKK 53
F-box_FBXW4 cd20090
F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, ...
 166-205 7.36e-04

F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, also called dactylin, or F-box and WD-40 domain-containing protein 4, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is likely to be involved in key signaling pathways crucial for normal limb development. It may participate in Wnt signaling and act as a novel tumor suppressor that regulates important cellular processes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438853  Cd Length: 47  Bit Score: 37.58  E-value: 7.36e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 61743926 166 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWRE 205
Cdd:cd20090   5 LPDDLLFLIFSYLDPASLGRLSQVCRRLYRLISRDAVWRR 44
Nsa1_WDR74-like cd22850
Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 ...
 329-377 7.52e-04

Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from fungi and WDR74 (WD repeat-containing protein 74) from mammals and plants, are homologous essential factors for ribosome assembly. In cooperation with the assembly factor Rix7/NVL2, Nsa1/WDR74 participates in an early cleavage of the pre-rRNA processing pathway. Rix7/NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of Nsa1/WDR74 from nucleolar pre-60S particles. Nsa1/WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase Rix7/NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439302 [Multi-domain]  Cd Length: 333  Bit Score: 41.85  E-value: 7.52e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 61743926 329 NAETGECIHTLYGH--TSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLH 377
Cdd:cd22850 263 TGKLLGRLLGKYGGsiTGAVRHPELFDPYLASGGLDRYLRVFDIETRELLA 313
F-box_FBXO10 cd22090
F-box domain found in F-box only protein 10 (FBXO10) and similar proteins; FBXO10, also called ...
 163-207 2.71e-03

F-box domain found in F-box only protein 10 (FBXO10) and similar proteins; FBXO10, also called FBX10, or PRMT11, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an anti-apoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2. It also associates with the receptor for advanced glycation end products (RAGE) to mediate its ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438862  Cd Length: 50  Bit Score: 36.18  E-value: 2.71e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 61743926 163 ISLLPKELALYVLSFLEPKDLLQAAQTCRYWR--ILAEDNLLWREKC 207
Cdd:cd22090   2 VTGLPLELWRLILAYLPVRDLCRCCQVCRAWYelILSLDSTRWKQLY 48
F-box_D3-like cd22140
F-box domain found in Oryza sativa F-box/LRR-repeat Max2 homolog (D3) and similar proteins; D3 ...
 166-200 2.84e-03

F-box domain found in Oryza sativa F-box/LRR-repeat Max2 homolog (D3) and similar proteins; D3 is the ortholog of Arabidopsis MORE AXILLARY GROWTH2 (MAX2) and DWARF14 (AtD14) in rice. These proteins are essential signaling components to regulate strigolactone (SL)-repressed plant branching. In rice shoot branching inhibition, the SL-metabolizing alpha/beta hydrolase D14 interacts with the F-box protein D3 to ubiquitinate and degrade the transcription repressor D53. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438912  Cd Length: 38  Bit Score: 35.81  E-value: 2.84e-03
                        10        20        30
                ....*....|....*....|....*....|....*
gi 61743926 166 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDN 200
Cdd:cd22140   4 LPEDLLLHILSFLNLRDRLNLSLTCKRLRALAYSD 38
WD40 pfam00400
WD domain, G-beta repeat;
453-489 4.25e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 4.25e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 61743926   453 GNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWD 489
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
F-box_AtSKIP5-like cd22163
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 5 (AtSKIP5) and similar ...
 163-203 5.50e-03

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 5 (AtSKIP5) and similar proteins; AtSKIP5, also called F-box protein SKIP5, is a component of SCF (SKP1-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438934  Cd Length: 46  Bit Score: 35.01  E-value: 5.50e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 61743926 163 ISLLPKELALYVLSFLEPK-DLLQAAQTCRYWRILAEDNLLW 203
Cdd:cd22163   1 INDLDDDCLMHIFSFLTPLpDRFNAARVCKRWRALALDPRSW 42
F-box_FBXW9 cd22135
F-box domain found in F-box/WD repeat-containing protein 9 (FBXW9) and similar proteins; FBXW9, ...
 166-206 6.94e-03

F-box domain found in F-box/WD repeat-containing protein 9 (FBXW9) and similar proteins; FBXW9, also called F-box and WD-40 domain-containing protein 9, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438907  Cd Length: 45  Bit Score: 34.95  E-value: 6.94e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 61743926 166 LPKELALYVLSFLEPKDLLQA-AQTCRYWRILAEDNLLWREK 206
Cdd:cd22135   4 LPPELLLHICSYLDARFVLHVlPLVCKTFRDILSDETTWRIR 45
F-box_DmSKP2-like cd22149
F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and ...
 166-204 7.25e-03

F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and similar proteins; DmSKP2 is a Drosophila F-box protein that regulates cell proliferation by targeting Dacapo (Dap) for ubiquitination and proteasome-mediated degradation. It plays a role in maintaining diploidy of mitotic cells during development. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438920  Cd Length: 43  Bit Score: 34.66  E-value: 7.25e-03
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 61743926 166 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 204
Cdd:cd22149   4 LSDEIILSIFKWLPKKTLARCARVCRRWKRLCFDESLWR 42
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 432-542 9.03e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 38.51  E-value: 9.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743926   432 DGIHVVSGSLDTSIRVWDVETGNCIHTLTghQSLTSGMELKDNILvsgnADSTVKIwdiktgqclqtLQGpnkHQSAVTC 511
Cdd:pfam20426 135 DGSILATGSYDTTVMVWEVLRGRSSEKRS--RNTQTEFPRKDHVI----AETPFHI-----------LCG---HDDIITC 194

                          90       100       110
                  ....*....|....*....|....*....|...
gi 61743926   512 LQFNK--NFVITSSDDGTVKLWDLKTGEFIRNL 542
Cdd:pfam20426 195 LYVSVelDIVISGSKDGTCIFHTLREGRYVRSI 227
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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