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Conserved domains on  [gi|1676336641|ref|NP_001012527|]
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membrane-associated transporter protein isoform b [Homo sapiens]

Protein Classification

SLC45 family MFS transporter( domain architecture ID 13022743)

SLC45 (solute carrier 45) family major facilitator superfamily (MFS) transporter facilitates the transport of sugars such as sucrose, glucose, and maltose into the cell, with the concomitant uptake of protons (symport system)

CATH:  1.20.1250.20
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
35-453 3.65e-137

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 400.85  E-value: 3.65e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641  35 LIMHSMAMFGREFCYAVEAAYVTPVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMML 114
Cdd:cd17313     1 LFLLGFGFFGIEFGWALENSYVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVGAPLAA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 115 VGMALYLNGATVVAALIANPRRklvWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGLHYHALFTGFGGALG 194
Cdd:cd17313    81 LGLILIPNAADIGLALGDGPRT---WALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 195 YLLGAIDWAHLELGRLLGTEFQVMFFFSALVLTLCFTVHLCSISEAPLTEVAkgippqqtpqdpplssdgmyeygsiekv 274
Cdd:cd17313   158 YLLGAILWDHNWFGFALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEA---------------------------- 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 275 kngyvnpelamqgaknKNHAEQTRRAMTLKSLLRALVNMPPHYRYLCISHLIGWTAFLSNMLFFTDFMGQIVYRGdpysa 354
Cdd:cd17313   210 ----------------GEHSENPSLGEVLKSLLKLLKIMPRSLLRLLLVIFFWWIAFFPFELFFTDYMGEEVYHG----- 268
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 355 hNSTEFLIYERGVEVGCWGLCINSVFSSLYSYFQKVLVSYIGLKGLYFTGYLLFGLGTGFIGLFPNVYSTLVLCSLFGVM 434
Cdd:cd17313   269 -TSAASSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIG 347
                         410
                  ....*....|....*....
gi 1676336641 435 SSTLYTVPFNLITEYHREE 453
Cdd:cd17313   348 WATININPYPLVSDYHSES 366
 
Name Accession Description Interval E-value
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
35-453 3.65e-137

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 400.85  E-value: 3.65e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641  35 LIMHSMAMFGREFCYAVEAAYVTPVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMML 114
Cdd:cd17313     1 LFLLGFGFFGIEFGWALENSYVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVGAPLAA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 115 VGMALYLNGATVVAALIANPRRklvWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGLHYHALFTGFGGALG 194
Cdd:cd17313    81 LGLILIPNAADIGLALGDGPRT---WALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 195 YLLGAIDWAHLELGRLLGTEFQVMFFFSALVLTLCFTVHLCSISEAPLTEVAkgippqqtpqdpplssdgmyeygsiekv 274
Cdd:cd17313   158 YLLGAILWDHNWFGFALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEA---------------------------- 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 275 kngyvnpelamqgaknKNHAEQTRRAMTLKSLLRALVNMPPHYRYLCISHLIGWTAFLSNMLFFTDFMGQIVYRGdpysa 354
Cdd:cd17313   210 ----------------GEHSENPSLGEVLKSLLKLLKIMPRSLLRLLLVIFFWWIAFFPFELFFTDYMGEEVYHG----- 268
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 355 hNSTEFLIYERGVEVGCWGLCINSVFSSLYSYFQKVLVSYIGLKGLYFTGYLLFGLGTGFIGLFPNVYSTLVLCSLFGVM 434
Cdd:cd17313   269 -TSAASSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIG 347
                         410
                  ....*....|....*....
gi 1676336641 435 SSTLYTVPFNLITEYHREE 453
Cdd:cd17313   348 WATININPYPLVSDYHSES 366
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
31-449 2.05e-27

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 114.13  E-value: 2.05e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641  31 PTSRLIMHSMAMFGREFCYAVEAAYVTPVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLG 110
Cdd:TIGR01301   2 PLRKLLRVASVAAGVQFGWALQLSLLTPYVQELGIPHAWASIIWLCGPLSGLLVQPLVGYLSDRCTSRFGRRRPFIAAGA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 111 VmmLVGMALYLNG-ATVVAALIANPRRKLV--WAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEK--GLHYHAL 185
Cdd:TIGR01301  82 A--LVAFAVILIGfAADIGHLFGDNLDKKTkpRAIIVFVVGFWILDVANNMLQGPCRAFLADLTGGDARRTriANAYFSF 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 186 FTGFGGALGYLLGAID-WAHL------ELGRLLGTEFQVMFFFSALVLTLCFTVHLCSISEAPLTevakgippqqtpqdp 258
Cdd:TIGR01301 160 FMAIGNVLGYAAGAYSgLYKIfpftktEACGVSCANLKSCFLIDIILLAILTYIALSAVKENPLI--------------- 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 259 plssdgmyeygsiekVKNGYVNPELAMQGAKNKnhaeqtrrAMTLKSLLRALVNMPPHYRYLCISHLIGWTAFLSNMLFF 338
Cdd:TIGR01301 225 ---------------GSDDFINSEAAPPSKHGE--------EAFFGELFGAFKYLPRPVWILLLVTCLNWIAWFPFILFD 281
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 339 TDFMGQIVYRGDPYSAHnsteflIYERGVEVGCWGLCINSVFSSLYSYFQKVL----------------VSYIGLKGLYF 402
Cdd:TIGR01301 282 TDWMGREVYGGSVNQGA------KYDDGVRAGAFGLMLNSVVLGITSIGMEKLcrgwgagkrlwgivniILAICLAATVL 355
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1676336641 403 TGYLL----FGLGTGFIGLFPN--VYSTLVLCSLFGVMSSTLYTVPFNLITEY 449
Cdd:TIGR01301 356 VTYVAknsrYYDGDGESLPPPTgiKASALIVFAILGIPLAITYSIPFALASIR 408
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
28-448 2.65e-21

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 95.74  E-value: 2.65e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641  28 PKRPTSRLIMHSMAMFGREFCYAVEAAYVTPVLLSV-GLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYI 106
Cdd:COG2211     5 KKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVlGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWI 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 107 LTLGVMMLVGMALylngatVVAALIANPRRKLVWAIsvtmIGVVLFDFAADFIDGPIKAYLFD-VCSHQDKEKGLHYHAL 185
Cdd:COG2211    85 LIGAIPLALSFVL------LFTAPDLSPTGKLIYAL----VTYLLLGLAYTLVNIPYSALGAElTPDYEERTRLSSWRFA 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 186 FTGFGGALGYLLGAIDWAHLELGRLLGteFQVMFFFSALVLTLCFTVHLCSISEAPLTEVAKGippqqtpqdpplssdgm 265
Cdd:COG2211   155 FAGLGGLLASVLPPPLVAAFGGDAALG--YRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKV----------------- 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 266 yeygsiekvkngyvnpelamqgaknknhaeqtrramTLKSLLRALVNMPPhYRYLCISHLIGWTAFLSNMLFFTDFMGQI 345
Cdd:COG2211   216 ------------------------------------SLKESLKALLKNRP-FLLLLLAYLLFFLALALVAALLLYYFKYV 258
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 346 VYRGDPYSAhnstefliyergvevgcWGLCINSVFSSLYSYFQKVLVSYIGLKGLYFTGYLLFGLGTGFIGLFP--NVYS 423
Cdd:COG2211   259 LGLSAALVG-----------------LLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWL 321
                         410       420
                  ....*....|....*....|....*
gi 1676336641 424 TLVLCSLFGVMSSTLYTVPFNLITE 448
Cdd:COG2211   322 LLVLAALAGIGLGAILVLPWAMLAD 346
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
37-154 1.75e-05

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 46.92  E-value: 1.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641  37 MHSMAMFGREFCYAVEAAYVTPVLLSV-GLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMMLV 115
Cdd:pfam13347   1 GYGSGALAAGIKYAGLATYLLYFYTDVlGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILAV 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1676336641 116 GMALylngatVVAALIANPRRKLVWAIsVTMIGV-VLFDF 154
Cdd:pfam13347  81 SFIL------LFTPPELGRAPLFIWLL-ATYILLrIAYTF 113
 
Name Accession Description Interval E-value
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
35-453 3.65e-137

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 400.85  E-value: 3.65e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641  35 LIMHSMAMFGREFCYAVEAAYVTPVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMML 114
Cdd:cd17313     1 LFLLGFGFFGIEFGWALENSYVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVGAPLAA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 115 VGMALYLNGATVVAALIANPRRklvWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGLHYHALFTGFGGALG 194
Cdd:cd17313    81 LGLILIPNAADIGLALGDGPRT---WALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 195 YLLGAIDWAHLELGRLLGTEFQVMFFFSALVLTLCFTVHLCSISEAPLTEVAkgippqqtpqdpplssdgmyeygsiekv 274
Cdd:cd17313   158 YLLGAILWDHNWFGFALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEA---------------------------- 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 275 kngyvnpelamqgaknKNHAEQTRRAMTLKSLLRALVNMPPHYRYLCISHLIGWTAFLSNMLFFTDFMGQIVYRGdpysa 354
Cdd:cd17313   210 ----------------GEHSENPSLGEVLKSLLKLLKIMPRSLLRLLLVIFFWWIAFFPFELFFTDYMGEEVYHG----- 268
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 355 hNSTEFLIYERGVEVGCWGLCINSVFSSLYSYFQKVLVSYIGLKGLYFTGYLLFGLGTGFIGLFPNVYSTLVLCSLFGVM 434
Cdd:cd17313   269 -TSAASSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIG 347
                         410
                  ....*....|....*....
gi 1676336641 435 SSTLYTVPFNLITEYHREE 453
Cdd:cd17313   348 WATININPYPLVSDYHSES 366
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
31-449 2.05e-27

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 114.13  E-value: 2.05e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641  31 PTSRLIMHSMAMFGREFCYAVEAAYVTPVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLG 110
Cdd:TIGR01301   2 PLRKLLRVASVAAGVQFGWALQLSLLTPYVQELGIPHAWASIIWLCGPLSGLLVQPLVGYLSDRCTSRFGRRRPFIAAGA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 111 VmmLVGMALYLNG-ATVVAALIANPRRKLV--WAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEK--GLHYHAL 185
Cdd:TIGR01301  82 A--LVAFAVILIGfAADIGHLFGDNLDKKTkpRAIIVFVVGFWILDVANNMLQGPCRAFLADLTGGDARRTriANAYFSF 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 186 FTGFGGALGYLLGAID-WAHL------ELGRLLGTEFQVMFFFSALVLTLCFTVHLCSISEAPLTevakgippqqtpqdp 258
Cdd:TIGR01301 160 FMAIGNVLGYAAGAYSgLYKIfpftktEACGVSCANLKSCFLIDIILLAILTYIALSAVKENPLI--------------- 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 259 plssdgmyeygsiekVKNGYVNPELAMQGAKNKnhaeqtrrAMTLKSLLRALVNMPPHYRYLCISHLIGWTAFLSNMLFF 338
Cdd:TIGR01301 225 ---------------GSDDFINSEAAPPSKHGE--------EAFFGELFGAFKYLPRPVWILLLVTCLNWIAWFPFILFD 281
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 339 TDFMGQIVYRGDPYSAHnsteflIYERGVEVGCWGLCINSVFSSLYSYFQKVL----------------VSYIGLKGLYF 402
Cdd:TIGR01301 282 TDWMGREVYGGSVNQGA------KYDDGVRAGAFGLMLNSVVLGITSIGMEKLcrgwgagkrlwgivniILAICLAATVL 355
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1676336641 403 TGYLL----FGLGTGFIGLFPN--VYSTLVLCSLFGVMSSTLYTVPFNLITEY 449
Cdd:TIGR01301 356 VTYVAknsrYYDGDGESLPPPTgiKASALIVFAILGIPLAITYSIPFALASIR 408
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
28-448 2.65e-21

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 95.74  E-value: 2.65e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641  28 PKRPTSRLIMHSMAMFGREFCYAVEAAYVTPVLLSV-GLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYI 106
Cdd:COG2211     5 KKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVlGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWI 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 107 LTLGVMMLVGMALylngatVVAALIANPRRKLVWAIsvtmIGVVLFDFAADFIDGPIKAYLFD-VCSHQDKEKGLHYHAL 185
Cdd:COG2211    85 LIGAIPLALSFVL------LFTAPDLSPTGKLIYAL----VTYLLLGLAYTLVNIPYSALGAElTPDYEERTRLSSWRFA 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 186 FTGFGGALGYLLGAIDWAHLELGRLLGteFQVMFFFSALVLTLCFTVHLCSISEAPLTEVAKGippqqtpqdpplssdgm 265
Cdd:COG2211   155 FAGLGGLLASVLPPPLVAAFGGDAALG--YRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKV----------------- 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 266 yeygsiekvkngyvnpelamqgaknknhaeqtrramTLKSLLRALVNMPPhYRYLCISHLIGWTAFLSNMLFFTDFMGQI 345
Cdd:COG2211   216 ------------------------------------SLKESLKALLKNRP-FLLLLLAYLLFFLALALVAALLLYYFKYV 258
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 346 VYRGDPYSAhnstefliyergvevgcWGLCINSVFSSLYSYFQKVLVSYIGLKGLYFTGYLLFGLGTGFIGLFP--NVYS 423
Cdd:COG2211   259 LGLSAALVG-----------------LLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWL 321
                         410       420
                  ....*....|....*....|....*
gi 1676336641 424 TLVLCSLFGVMSSTLYTVPFNLITE 448
Cdd:COG2211   322 LLVLAALAGIGLGAILVLPWAMLAD 346
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
39-455 2.13e-20

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 92.49  E-value: 2.13e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641  39 SMAMFGREFCYAVEAAYVTPVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDhcrsRWGRRRPYILTLGVMMLVGMA 118
Cdd:cd06174     2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLAD----RFGRRPVLLLGLLLFALGALL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 119 LYlngatvvaalianprrkLVWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGLHYHALFTGFGGALGYLLG 198
Cdd:cd06174    78 FA-----------------FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLG 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 199 AIDWAHLELGrllgteFQVMFFFSALVLTLCFTVHLCSISEAPLTEVAKGIPPQQtpqdpplssdgmyeygsiekvkngy 278
Cdd:cd06174   141 GILASSLGFG------WRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASS------------------------- 189
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 279 vnpelamqgaknknhaeqtrrAMTLKSLLRALVNmpPHYRYLCISHLIGWTAFLSNMLFFTDFMGQIVYrgdpysahnst 358
Cdd:cd06174   190 ---------------------KSVLKLLKRVLKN--PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGG----------- 235
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 359 efliyeRGVEVGCWGLCINSVFSSLYSYFQKVLVSY-IGLKGLYFTGYLLFGLGTGFIGLFPNVYSTLVLCSLFGVMSST 437
Cdd:cd06174   236 ------LSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGG 309
                         410
                  ....*....|....*...
gi 1676336641 438 LYTVPFNLITEYHREEEK 455
Cdd:cd06174   310 LLPLSFALIAELFPPEIR 327
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
37-154 1.75e-05

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 46.92  E-value: 1.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641  37 MHSMAMFGREFCYAVEAAYVTPVLLSV-GLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMMLV 115
Cdd:pfam13347   1 GYGSGALAAGIKYAGLATYLLYFYTDVlGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILAV 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1676336641 116 GMALylngatVVAALIANPRRKLVWAIsVTMIGV-VLFDF 154
Cdd:pfam13347  81 SFIL------LFTPPELGRAPLFIWLL-ATYILLrIAYTF 113
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
55-448 4.77e-05

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 45.67  E-value: 4.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641  55 YVTPVLlsvGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGV-MMLVGMALYLNGAtvvaaliAN 133
Cdd:cd17332    25 FYTDVL---GLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRWGRFRPWLLWGAIpLALLFVLLFTTPD-------GS 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 134 PRRKLVWAISVTMigvvLFDFAADFIDGPIKAyLFDVCSHQDKEKG--LHYHALFTGFGGALGYLLGAIDWAHLELGRLL 211
Cdd:cd17332    95 GTGKLIYALITYI----LLDLLYTLVNIPYTA-LIPELTDDPEERTslTSWRMFFATIGGLLVTVLPPPLVAYFGGGNAS 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 212 GTEFQVMFFFSALVLTLCFTVHLcsiseapltevakgippqqtpqdpplssdgmyeyGSIEKVkngyvnpelamqgaknk 291
Cdd:cd17332   170 RGYFLTALIIGIIGIILLLICFF----------------------------------GTRERV----------------- 198
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 292 NHAEQTRRAMTLKSLLRALVNMPPHYRyLCISHLIGWTAF---LSNMLFFTDfmgqivyrgdpYSAHNSTEFLIYergve 368
Cdd:cd17332   199 VPPEEEKSKLPLLKSLKALLKNRPFLI-LLLAYLLYFLAFnivNTVLVYYFK-----------YVLGGRAELVLL----- 261
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 369 VGCWGLCINSVFSSLYSYFQKvlvsyIGLKGLYFTGYLLFGLGTG--FIGLFPNVYSTLVLCSLFGVMSSTLYTVPFNLI 446
Cdd:cd17332   262 LLLILSGALLALLPWPPLKKR-----FGKKKAFFIGLLLAILGLLllFFLPPGNLVLILVLAVLAGIGYGGANLLPWAML 336

                  ..
gi 1676336641 447 TE 448
Cdd:cd17332   337 AD 338
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
63-249 4.68e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 42.21  E-value: 4.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641  63 VGLPSSLYSIVWFLSPILGFLLQPVVGSASDhcrsRWGRRRpyiltlgvMMLVGMALylngATVVAALIAnprrkLVWAI 142
Cdd:cd17329    30 LGLSASIVGLVLALSAVAGIVASLIGGRLAD----RFGRKP--------VMLAGLLL----RALGFALLG-----FAHSP 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 143 SVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGLHYHALFTGFGGALGYLLGA-IDWAHLELGRLLGTefqVMFFF 221
Cdd:cd17329    89 WLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGlLLLYSFRLLFLAAA---VLFLL 165
                         170       180
                  ....*....|....*....|....*...
gi 1676336641 222 SALVLTLCFTVHLCSISEAPLTEVAKGI 249
Cdd:cd17329   166 AALVLLFLLPETRPKRRAAEKTEILRGY 193
MFS_BCD_PucC-like cd06176
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ...
61-157 2.24e-03

Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 349950 [Multi-domain]  Cd Length: 409  Bit Score: 40.18  E-value: 2.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641  61 LSVGLPSSLYSIVWFLSPilgflLQPVVGSASDHCRSRWGRRRPYILtLGVMMLVGMALylnGATVVAALIANPRRK--- 137
Cdd:cd06176    33 LPATLVGLLIALHYLVAP-----LRVWIGHRSDTHPLRGYRRTPYIW-LGMLLLALGLA---LAPFAALLLAGAAFWlgl 103
                          90       100
                  ....*....|....*....|....*..
gi 1676336641 138 -------LVWAISVTMIGVVLFDFAAD 157
Cdd:cd06176   104 alavlafLLYGIGVGAAGTAFLALLAD 130
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
35-160 2.75e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 39.89  E-value: 2.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641  35 LIMHSMAMFGREFCYAVEAAYVTPVLLSV-GLPSSLYSIVWFLSPILGFLLQPVVGSASDhcrsRWGRRRPYILTLGVMM 113
Cdd:COG2211   230 FLLLLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAALLGAPLWPRLAK----RFGKKKAFIIGLLLAA 305
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1676336641 114 LVGMALYLNGAT-VVAALIANprrkLVWAISVTMIGVVLFDFAADFID 160
Cdd:COG2211   306 LGLLLLFFLGPGnLWLLLVLA----ALAGIGLGAILVLPWAMLADVVD 349
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
55-230 3.05e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 39.84  E-value: 3.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641  55 YVTPVLLSV-GLPSSLYSIVWFLSPILGFLLQPVVGSASDhcrsrWGRRRPYILTLGVMMLVGMALYLNGATVVAALIAN 133
Cdd:cd17324   220 YLAPFLTDVpGFSSSAIIGLLLLFGVAGVVGSPLAGRLAD-----RGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGL 294
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 134 prrkLVWAISVTMIGVVLFDFAADfidgpikaylfdvCSHQDKEKGLhyhALFTGF---GGALGYLLGAIDWAHLELGRL 210
Cdd:cd17324   295 ----VLWGLGFFAAHSALQTRVLR-------------LAPEARGLAS---SLYLAAynlGGALGAALGGLVLDHGGWAGV 354
                         170       180
                  ....*....|....*....|
gi 1676336641 211 LGtefqVMFFFSALVLTLCF 230
Cdd:cd17324   355 GW----VGAALLLLALLLAL 370
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
66-200 4.21e-03

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 39.37  E-value: 4.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641  66 PSSLYSIVWFLSPILGFLLQPVVGSASDHCrsrwGRRRPYILTLGVMMLVGMAL--YLNGATVVAALIANprrklvwais 143
Cdd:COG2270    50 ATALWGYALAIAGLLVALLAPVLGAIADRS----GRKKPFLAFFTLLGVLATAAlfFVAPGGLWLGLLLF---------- 115
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1676336641 144 vtMIGVVLFDFAADFIDgpikAYLFDVCSHQDKEKGlhyhalfTGFGGALGYLLGAI 200
Cdd:COG2270   116 --VLANIGFEGSLVFYN----AFLPDIATPEEIGRV-------SGLGWALGYLGGVL 159
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
29-157 5.18e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 38.80  E-value: 5.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641  29 KRPTSRLIMHSMAMFGreFCYAVEAAYVTPVLLSV-GLPSSLYSIVWFLSPILGFLLQPVVGSASDhcrsRWGRRRPYIL 107
Cdd:COG2814   205 RRPRLLLLLLLAFLLG--FGFFALFTYLPLYLQEVlGLSASAAGLLLALFGLGGVLGALLAGRLAD----RFGRRRLLLI 278
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1676336641 108 TLgVMMLVGMALYLNGATVVAALIANprrkLVWAISVTMIGVVLFDFAAD 157
Cdd:COG2814   279 GL-LLLALGLLLLALAGSLWLLLLAL----FLLGFGFGLLFPLLQALVAE 323
MFS_1 pfam07690
Major Facilitator Superfamily;
35-230 5.38e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 38.94  E-value: 5.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641  35 LIMHSMAMFGRefcYAVEAAYVTPVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDhcrsRWGRRRPYILTLGVMML 114
Cdd:pfam07690   2 FLAAFLAALGR---SLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSD----RFGRRRVLLIGLLLFAL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 115 VGMALYLngatvvaalianprrklVWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGLHYHALFTGFGGALG 194
Cdd:pfam07690  75 GLLLLLF-----------------ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALG 137
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1676336641 195 YLLGAIdwahleLGRLLGteFQVMFFFSALVLTLCF 230
Cdd:pfam07690 138 PLLGGL------LASLFG--WRAAFLILAILSLLAA 165
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
63-232 8.72e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 38.33  E-value: 8.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641  63 VGLPSSLYSIVWFLSPILGFLLQPVVGSASDhcrsRWGRRRpyiltlgvMMLVGMALylngatVVAALIANPRRKLVWAI 142
Cdd:cd17325   230 GGLSPAQIGLLFGAQGLASALSQPPAGKLSD----RIGRKP--------LILIGLLL------SAVALLLLPLATSFWLL 291
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 143 svtMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGLHYHALFTGFGGALGYLLGAIDWAHLelgrllgtEFQVMFFFS 222
Cdd:cd17325   292 ---LLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF--------GFATPFLAA 360
                         170
                  ....*....|
gi 1676336641 223 ALVLTLCFTV 232
Cdd:cd17325   361 AALLLLAAVL 370
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
63-232 9.60e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 37.94  E-value: 9.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641  63 VGLPSSLYSIVWFLSpilgfllQPVVGSASDhcrsRWGRRRpyILTLGVMmlvgmalylnGATVVAALIAnprrklvWAI 142
Cdd:cd17330    36 VGLLQSSYSLGQFLA-------SPLWGRLSD----RYGRKP--VLLLSLA----------GSAVSYVLLG-------LSR 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676336641 143 SVTMIgvvlfdFAADFIDG-------PIKAYLFDVCSHQDKEKGLHYHALFTGFGGALGYLLGAIdwahleLGRLLGteF 215
Cdd:cd17330    86 NLWLL------FLARFLDGltggnvsVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGF------LSTPYG--Y 151
                         170
                  ....*....|....*..
gi 1676336641 216 QVMFFFSALVLTLCFTV 232
Cdd:cd17330   152 ALPFLVAAALALLNLVL 168
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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