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Conserved domains on  [gi|59933236|ref|NP_001012366|]
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kelch repeat-containing protein [Danio rerio]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 20682901)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions; similar to Homo sapiens Kelch domain-containing protein 2, a substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
265-529 1.41e-22

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 97.53  E-value: 1.41e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236 265 GPTPEARiGHTATYDPESKrIFVFGGSKHKKWFNDVHILDTQSWRWTLVeAQGKVPPLAYHSCSMFRGELFVFGGVfpRP 344
Cdd:COG3055   7 PDLPTPR-SEAAAALLDGK-VYVAGGLSGGSASNSFEVYDPATNTWSEL-APLPGPPRHHAAAVAQDGKLYVFGGF--TG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236 345 HPEPDGCSDSIYIFNPEMAIWYQpivNGEKPAPRSGHSACVMQGRIFVFGGWDTPVCFNDMFMLDLGLMEFSPVktsGTA 424
Cdd:COG3055  82 ANPSSTPLNDVYVYDPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQL---APL 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236 425 PSPRSWHGCAVLSESSFLIHGGYNG-----------------------------------NNALSDAFIFNTDTSCWSSL 469
Cdd:COG3055 156 PTPRDHLAAAVLPDGKILVIGGRNGsgfsntwttlaplptaraghaaavlggkilvfggeSGFSDEVEAYDPATNTWTAL 235

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 59933236 470 -TLPQlnsvPRAGHSIITmpttckkgsIDEQeellesapqtLLVFGGGDNEGSFFSDLFTM 529
Cdd:COG3055 236 gELPT----PRHGHAAVL---------TDGK----------VYVIGGETKPGVRTPLVTSA 273
Kelch_4 pfam13418
Galactose oxidase, central domain;
215-262 5.30e-03

Galactose oxidase, central domain;


:

Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 35.28  E-value: 5.30e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 59933236   215 GRWGQTLCPIDPQTAILIGGQGARMQFCKDpIWKLCTEDLSWVPAETL 262
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGGEGEDGTLLSD-LWVFDLSTNEWTRLGSL 47
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
265-529 1.41e-22

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 97.53  E-value: 1.41e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236 265 GPTPEARiGHTATYDPESKrIFVFGGSKHKKWFNDVHILDTQSWRWTLVeAQGKVPPLAYHSCSMFRGELFVFGGVfpRP 344
Cdd:COG3055   7 PDLPTPR-SEAAAALLDGK-VYVAGGLSGGSASNSFEVYDPATNTWSEL-APLPGPPRHHAAAVAQDGKLYVFGGF--TG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236 345 HPEPDGCSDSIYIFNPEMAIWYQpivNGEKPAPRSGHSACVMQGRIFVFGGWDTPVCFNDMFMLDLGLMEFSPVktsGTA 424
Cdd:COG3055  82 ANPSSTPLNDVYVYDPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQL---APL 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236 425 PSPRSWHGCAVLSESSFLIHGGYNG-----------------------------------NNALSDAFIFNTDTSCWSSL 469
Cdd:COG3055 156 PTPRDHLAAAVLPDGKILVIGGRNGsgfsntwttlaplptaraghaaavlggkilvfggeSGFSDEVEAYDPATNTWTAL 235

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 59933236 470 -TLPQlnsvPRAGHSIITmpttckkgsIDEQeellesapqtLLVFGGGDNEGSFFSDLFTM 529
Cdd:COG3055 236 gELPT----PRHGHAAVL---------TDGK----------VYVIGGETKPGVRTPLVTSA 273
PLN02153 PLN02153
epithiospecifier protein
 284-494 7.56e-12

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 66.55  E-value: 7.56e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236  284 RIFVFGGSKHKKWFNDVHILDTQSWRWTL---VEAQGKVPPLAYHSCSMFRGELFVFGGVFPRPHPEPDGCSDSIYIFNP 360
Cdd:PLN02153  87 KLYIFGGRDEKREFSDFYSYDTVKNEWTFltkLDEEGGPEARTFHSMASDENHVYVFGGVSKGGLMKTPERFRTIEAYNI 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236  361 EMAIWYQPIVNGEKPAPRSGHSACVMQGRIFVFGGWDTPVC--------FNDMFMLDLGLMEFSPVKTSGTAPSPRSWHG 432
Cdd:PLN02153 167 ADGKWVQLPDPGENFEKRGGAGFAVVQGKIWVVYGFATSILpggksdyeSNAVQFFDPASGKWTEVETTGAKPSARSVFA 246

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236  433 CAVLSESSFLIHG-------GYNGNNALS-DAFIFNTDTSCWSSLTLPQLNSVPRAGHSIITMPTTCKKG 494
Cdd:PLN02153 247 HAVVGKYIIIFGGevwpdlkGHLGPGTLSnEGYALDTETLVWEKLGECGEPAMPRGWTAYTTATVYGKNG 316
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 377-410 2.08e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 44.53  E-value: 2.08e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 59933236   377 PRSGHSACVMQGRIFVFGGWDTPVCFNDMFMLDL 410
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDP 34
Kelch smart00612
Kelch domain;
445-487 2.22e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.08  E-value: 2.22e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 59933236    445 GGYNGNNALSDAFIFNTDTSCWSSltLPQLNsVPRAGHSIITM 487
Cdd:smart00612   6 GGFDGGQRLKSVEVYDPETNKWTP--LPSMP-TPRSGHGVAVI 45
Kelch_4 pfam13418
Galactose oxidase, central domain;
215-262 5.30e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 35.28  E-value: 5.30e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 59933236   215 GRWGQTLCPIDPQTAILIGGQGARMQFCKDpIWKLCTEDLSWVPAETL 262
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGGEGEDGTLLSD-LWVFDLSTNEWTRLGSL 47
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
265-529 1.41e-22

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 97.53  E-value: 1.41e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236 265 GPTPEARiGHTATYDPESKrIFVFGGSKHKKWFNDVHILDTQSWRWTLVeAQGKVPPLAYHSCSMFRGELFVFGGVfpRP 344
Cdd:COG3055   7 PDLPTPR-SEAAAALLDGK-VYVAGGLSGGSASNSFEVYDPATNTWSEL-APLPGPPRHHAAAVAQDGKLYVFGGF--TG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236 345 HPEPDGCSDSIYIFNPEMAIWYQpivNGEKPAPRSGHSACVMQGRIFVFGGWDTPVCFNDMFMLDLGLMEFSPVktsGTA 424
Cdd:COG3055  82 ANPSSTPLNDVYVYDPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQL---APL 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236 425 PSPRSWHGCAVLSESSFLIHGGYNG-----------------------------------NNALSDAFIFNTDTSCWSSL 469
Cdd:COG3055 156 PTPRDHLAAAVLPDGKILVIGGRNGsgfsntwttlaplptaraghaaavlggkilvfggeSGFSDEVEAYDPATNTWTAL 235

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 59933236 470 -TLPQlnsvPRAGHSIITmpttckkgsIDEQeellesapqtLLVFGGGDNEGSFFSDLFTM 529
Cdd:COG3055 236 gELPT----PRHGHAAVL---------TDGK----------VYVIGGETKPGVRTPLVTSA 273
PLN02153 PLN02153
epithiospecifier protein
 284-494 7.56e-12

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 66.55  E-value: 7.56e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236  284 RIFVFGGSKHKKWFNDVHILDTQSWRWTL---VEAQGKVPPLAYHSCSMFRGELFVFGGVFPRPHPEPDGCSDSIYIFNP 360
Cdd:PLN02153  87 KLYIFGGRDEKREFSDFYSYDTVKNEWTFltkLDEEGGPEARTFHSMASDENHVYVFGGVSKGGLMKTPERFRTIEAYNI 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236  361 EMAIWYQPIVNGEKPAPRSGHSACVMQGRIFVFGGWDTPVC--------FNDMFMLDLGLMEFSPVKTSGTAPSPRSWHG 432
Cdd:PLN02153 167 ADGKWVQLPDPGENFEKRGGAGFAVVQGKIWVVYGFATSILpggksdyeSNAVQFFDPASGKWTEVETTGAKPSARSVFA 246

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236  433 CAVLSESSFLIHG-------GYNGNNALS-DAFIFNTDTSCWSSLTLPQLNSVPRAGHSIITMPTTCKKG 494
Cdd:PLN02153 247 HAVVGKYIIIFGGevwpdlkGHLGPGTLSnEGYALDTETLVWEKLGECGEPAMPRGWTAYTTATVYGKNG 316
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
200-399 4.19e-11

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 63.64  E-value: 4.19e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236 200 QTKTSSQTAQLdkPSGRWGQTLCPIDPQtaILIGGqGARMQFCKDPIWKLCTEDLSWVPAetlaeGPTPEARIGHTATYD 279
Cdd:COG3055  98 ATNTWTKLAPM--PTPRGGATALLLDGK--IYVVG-GWDDGGNVAWVEVYDPATGTWTQL-----APLPTPRDHLAAAVL 167

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236 280 PESKrIFVFGGSkHKKWFNDvhildtqswRWTlveaQGKVPPLA--YHSCSMFRGELFVFGGvfprphpePDGCSDSIYI 357
Cdd:COG3055 168 PDGK-ILVIGGR-NGSGFSN---------TWT----TLAPLPTAraGHAAAVLGGKILVFGG--------ESGFSDEVEA 224

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 59933236 358 FNPEMAIWYQpivNGEKPAPRSGHSACVMQGRIFVFGGWDTP 399
Cdd:COG3055 225 YDPATNTWTA---LGELPTPRHGHAAVLTDGKVYVIGGETKP 263
PLN02193 PLN02193
nitrile-specifier protein
 285-527 4.26e-09

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 58.81  E-value: 4.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236  285 IFVFGGSKHKKWFNDVHILDTQSWRWTLVEAQGKVP-PLAYHSCSMFRGELFVFGGVFPRPHPEpdgCSDSIYIFNPEma 363
Cdd:PLN02193 231 LYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEGPtPRSFHSMAADEENVYVFGGVSATARLK---TLDSYNIVDKK-- 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236  364 iWYQPIVNGEKPAPRSGHSACVMQGRIFVFGGWDTpvC-FNDMFMLDLGLMEFSPVKTSGTAPSPRSWHGCAVLSEsSFL 442
Cdd:PLN02193 306 -WFHCSTPGDSFSIRGGAGLEVVQGKVWVVYGFNG--CeVDDVHYYDPVQDKWTQVETFGVRPSERSVFASAAVGK-HIV 381

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236  443 IHGG--------YNGNNALSDA-FIFNTDTSCWSSL-TLPQLNSVPRAGHsiITMPTTckkGSIDEQeellesapQTLLV 512
Cdd:PLN02193 382 IFGGeiamdplaHVGPGQLTDGtFALDTETLQWERLdKFGEEEETPSSRG--WTASTT---GTIDGK--------KGLVM 448

                        250
                 ....*....|....*
gi 59933236  513 FGGGDNEGSFFSDLF 527
Cdd:PLN02193 449 HGGKAPTNDRFDDLF 463
PLN02193 PLN02193
nitrile-specifier protein
 256-449 7.06e-07

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 51.88  E-value: 7.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236  256 WVPAETLAEGPTPE-----ARIGHtatydpeskRIFVFGGSKHKKWFNDVH--ILDTQSWRWTLVEAQGKVPPLAYHSCS 328
Cdd:PLN02193 153 WIKVEQKGEGPGLRcshgiAQVGN---------KIYSFGGEFTPNQPIDKHlyVFDLETRTWSISPATGDVPHLSCLGVR 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236  329 MFR--GELFVFGGV-FPRPHpepdgcsDSIYIFNPEMAIW--YQPIVNGekPAPRSGHSACVMQGRIFVFGGWDTPVCFN 403
Cdd:PLN02193 224 MVSigSTLYVFGGRdASRQY-------NGFYSFDTTTNEWklLTPVEEG--PTPRSFHSMAADEENVYVFGGVSATARLK 294

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 59933236  404 DMFMLDLGLMEFSPVKTSGTAPSPRSWHGCAVLSESSFLIHgGYNG 449
Cdd:PLN02193 295 TLDSYNIVDKKWFHCSTPGDSFSIRGGAGLEVVQGKVWVVY-GFNG 339
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 377-410 2.08e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 44.53  E-value: 2.08e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 59933236   377 PRSGHSACVMQGRIFVFGGWDTPVCFNDMFMLDL 410
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDP 34
PLN02193 PLN02193
nitrile-specifier protein
 309-481 2.31e-06

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 49.95  E-value: 2.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236  309 RWTLVEAQGKVPPL-AYHSCSMFRGELFVFGGVFPRPHPepdgCSDSIYIFNPEMAIWYQPIVNGEKPaprsgHSACV-- 385
Cdd:PLN02193 152 KWIKVEQKGEGPGLrCSHGIAQVGNKIYSFGGEFTPNQP----IDKHLYVFDLETRTWSISPATGDVP-----HLSCLgv 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236  386 ----MQGRIFVFGGWDTPVCFNDMFMLDLGLMEFSPVKTSGTAPSPRSWHGCAVlSESSFLIHGGYNGNNALSDAFIFNT 461
Cdd:PLN02193 223 rmvsIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAA-DEENVYVFGGVSATARLKTLDSYNI 301

                        170       180
                 ....*....|....*....|
gi 59933236  462 DTSCWSSLTLPQLNSVPRAG 481
Cdd:PLN02193 302 VDKKWFHCSTPGDSFSIRGG 321
PLN02193 PLN02193
nitrile-specifier protein
 247-463 3.10e-06

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 49.57  E-value: 3.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236  247 WKLCTedlswvPAEtlaEGPTPeaRIGHTATYDPESkrIFVFGGSK--------------HKKWFNDVHILDTQSWRWT- 311
Cdd:PLN02193 256 WKLLT------PVE---EGPTP--RSFHSMAADEEN--VYVFGGVSatarlktldsynivDKKWFHCSTPGDSFSIRGGa 322

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236  312 -LVEAQGKVpplayhscsmfrgeLFVFGGvfprphpepDGCS-DSIYIFNPEMAIWYQPIVNGEKPAPRSGHSACVMQGR 389
Cdd:PLN02193 323 gLEVVQGKV--------------WVVYGF---------NGCEvDDVHYYDPVQDKWTQVETFGVRPSERSVFASAAVGKH 379

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236  390 IFVFGG--------WDTPVCFND-MFMLDLGLMEFSPVKTSGT---APSPRSWHGC---AVLSESSFLIHGG-YNGNNAL 453
Cdd:PLN02193 380 IVIFGGeiamdplaHVGPGQLTDgTFALDTETLQWERLDKFGEeeeTPSSRGWTASttgTIDGKKGLVMHGGkAPTNDRF 459

                        250
                 ....*....|
gi 59933236  454 SDAFIFNTDT 463
Cdd:PLN02193 460 DDLFFYGIDS 469
PHA03098 PHA03098
kelch-like protein; Provisional
 231-467 5.07e-06

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 49.00  E-value: 5.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236  231 LIGGQGARMQFCKDPI-WKLCTEDLSWVPaetlaegPTPEARIGHTATYDPEskRIFVFGGSKhkkwfNDVHILDTQSWR 309
Cdd:PHA03098 299 FIGGMNKNNLSVNSVVsYDTKTKSWNKVP-------ELIYPRKNPGVTVFNN--RIYVIGGIY-----NSISLNTVESWK 364

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236  310 -----WTlveaqgKVPPLAYHSCSMF----RGELFVFGGVFprphpEPDGCSDSIYIFNPEMAIWyqpIVNGEKPAPRSG 380
Cdd:PHA03098 365 pgeskWR------EEPPLIFPRYNPCvvnvNNLIYVIGGIS-----KNDELLKTVECFSLNTNKW---SKGSPLPISHYG 430

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236  381 HSACVMQGRIFVFGGW---DTPVCFNDMFMldlglmeFSPVKTSGTAPS----PRSWHGCAVLsESSFLIHGGYNGNNAL 453
Cdd:PHA03098 431 GCAIYHDGKIYVIGGIsyiDNIKVYNIVES-------YNPVTNKWTELSslnfPRINASLCIF-NNKIYVVGGDKYEYYI 502

                        250
                 ....*....|....
gi 59933236  454 SDAFIFNTDTSCWS 467
Cdd:PHA03098 503 NEIEVYDDKTNTWT 516
PLN02193 PLN02193
nitrile-specifier protein
 365-484 5.66e-06

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 48.80  E-value: 5.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236  365 WYQPIVNGEKPAPRSGHSACVMQGRIFVFGGWDTPVCFND--MFMLDLGLMEFSPVKTSGTAPSPRSWHGCAVLSESSFL 442
Cdd:PLN02193 153 WIKVEQKGEGPGLRCSHGIAQVGNKIYSFGGEFTPNQPIDkhLYVFDLETRTWSISPATGDVPHLSCLGVRMVSIGSTLY 232

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 59933236  443 IHGGYNGNNALSDAFIFNTDTSCWSSLTLPQLNSVPRAGHSI 484
Cdd:PLN02193 233 VFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSM 274
Kelch_3 pfam13415
Galactose oxidase, central domain;
388-436 8.52e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 40.35  E-value: 8.52e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 59933236   388 GRIFVFGGWDTP--VCFNDMFMLDLGLMEFspvKTSGTAPSPRSWHGCAVL 436
Cdd:pfam13415   2 DKLYIFGGLGFDgqTRLNDLYVYDLDTNTW---TQIGDLPPPRSGHSATYI 49
PLN02153 PLN02153
epithiospecifier protein
 372-470 1.28e-04

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 44.21  E-value: 1.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236  372 GEKPAPRSGHSACVMQGRIFVFGGWDTP--VCFNDMFMLDLGLMEFSPVKTSGTAPSPRSWHGCAVLSESSFLIHGGYNG 449
Cdd:PLN02153  17 GKGPGPRCSHGIAVVGDKLYSFGGELKPneHIDKDLYVFDFNTHTWSIAPANGDVPRISCLGVRMVAVGTKLYIFGGRDE 96

                         90       100
                 ....*....|....*....|.
gi 59933236  450 NNALSDAFIFNTDTSCWSSLT 470
Cdd:PLN02153  97 KREFSDFYSYDTVKNEWTFLT 117
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 375-410 1.66e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 39.09  E-value: 1.66e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 59933236   375 PAPRSGHSACVMQGRIFVFGGWDTP--VCFNDMFMLDL 410
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGGegQPSDDVYVLSL 38
Kelch smart00612
Kelch domain;
445-487 2.22e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.08  E-value: 2.22e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 59933236    445 GGYNGNNALSDAFIFNTDTSCWSSltLPQLNsVPRAGHSIITM 487
Cdd:smart00612   6 GGFDGGQRLKSVEVYDPETNKWTP--LPSMP-TPRSGHGVAVI 45
Kelch_4 pfam13418
Galactose oxidase, central domain;
270-315 2.58e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 38.75  E-value: 2.58e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 59933236   270 ARIGHTATYDPeSKRIFVFGGSKHK-KWFNDVHILDTQSWRWTLVEA 315
Cdd:pfam13418   1 PRAYHTSTSIP-DDTIYLFGGEGEDgTLLSDLWVFDLSTNEWTRLGS 46
PRK14131 PRK14131
N-acetylneuraminate epimerase;
259-406 6.85e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 41.92  E-value: 6.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59933236  259 AETLAEGPTP-----EARIGHTatydpeskrIFVFGGSKHKKWFndvhILDTQ--SWRWTLVeAQGKVPPLAYHSCSMFR 331
Cdd:PRK14131  19 AEQLPDLPVPfkngtGAIDNNT---------VYVGLGSAGTSWY----KLDLNapSKGWTKI-AAFPGGPREQAVAAFID 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 59933236  332 GELFVFGGVFPRPHPEPDGCSDSIYIFNPEMAIWYQpiVNGEKPAPRSGHSACVMQG-RIFVFGGWDTPVcFNDMF 406
Cdd:PRK14131  85 GKLYVFGGIGKTNSEGSPQVFDDVYKYDPKTNSWQK--LDTRSPVGLAGHVAVSLHNgKAYITGGVNKNI-FDGYF 157
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 427-470 1.22e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.82  E-value: 1.22e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 59933236   427 PRSWHGCAVLSESSFLIhGGYNGNNALSDAFIFNTDTSCWSSLT 470
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVI-GGFDGNQSLNSVEVYDPETNTWSKLP 43
PLN02772 PLN02772
guanylate kinase
 335-399 1.75e-03

guanylate kinase


Pssm-ID: 215414 [Multi-domain]  Cd Length: 398  Bit Score: 40.98  E-value: 1.75e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 59933236  335 FVFGGvfprpHPEPDGCSDSIYIFNPEMAIWYQPIVNGEKPAPRSGHSACVM-QGRIFVFGGWDTP 399
Cdd:PLN02772  38 YVIGG-----NHEGNTLSIGVQILDKITNNWVSPIVLGTGPKPCKGYSAVVLnKDRILVIKKGSAP 98
Kelch_4 pfam13418
Galactose oxidase, central domain;
427-470 2.68e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 36.05  E-value: 2.68e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 59933236   427 PRSWHGCAVLSESSFLIHGGYNGNN-ALSDAFIFNTDTSCWSSLT 470
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGGEGEDGtLLSDLWVFDLSTNEWTRLG 45
Kelch_3 pfam13415
Galactose oxidase, central domain;
331-385 2.95e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 35.73  E-value: 2.95e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 59933236   331 RGELFVFGGvfprPHPEPDGCSDSIYIFNPEMAIWYQPivnGEKPAPRSGHSACV 385
Cdd:pfam13415   1 GDKLYIFGG----LGFDGQTRLNDLYVYDLDTNTWTQI---GDLPPPRSGHSATY 48
Kelch_4 pfam13418
Galactose oxidase, central domain;
215-262 5.30e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 35.28  E-value: 5.30e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 59933236   215 GRWGQTLCPIDPQTAILIGGQGARMQFCKDpIWKLCTEDLSWVPAETL 262
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGGEGEDGTLLSD-LWVFDLSTNEWTRLGSL 47
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 268-308 6.05e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 34.85  E-value: 6.05e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 59933236   268 PEARIGHTATYDpeSKRIFVFGGSKH--KKWFNDVHILDTQSW 308
Cdd:pfam13854   1 PVPRYGHCAVTV--GDYIYLYGGYTGgeGQPSDDVYVLSLPTF 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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