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Conserved domains on  [gi|58801444|ref|NP_001011842|]
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olfactory receptor family 5 subfamily B member 118 [Mus musculus]

Protein Classification

family 5 olfactory receptor( domain architecture ID 11607531)

family 5 subfamily B olfactory receptor is a G-protein coupled receptor (GPCR) that plays a central role in olfaction, the sense of smell; GPCRs transmit physiological signals from the outside of the cell to the inside via G proteins by binding to an extracellular agonist, which induces conformational changes that lead to the activation of heterotrimeric G proteins, which then bind to and activate numerous downstream effector proteins

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
23-301 3.78e-157

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


:

Pssm-ID: 320529  Cd Length: 279  Bit Score: 439.93  E-value: 3.78e-157
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd15407   1 IPLFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPL 182
Cdd:cd15407  81 VVFATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 LDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSS 262
Cdd:cd15407 161 LALSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSS 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 58801444 263 NHSMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNAFKK 301
Cdd:cd15407 241 SHSMDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279
 
Name Accession Description Interval E-value
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
23-301 3.78e-157

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 439.93  E-value: 3.78e-157
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd15407   1 IPLFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPL 182
Cdd:cd15407  81 VVFATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 LDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSS 262
Cdd:cd15407 161 LALSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSS 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 58801444 263 NHSMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNAFKK 301
Cdd:cd15407 241 SHSMDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
29-302 1.28e-43

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 150.73  E-value: 1.28e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444    29 FTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVAFGAI 108
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444   109 ESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLLDISCS 188
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444   189 DTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSSNHSMD- 267
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPp 240
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 58801444   268 -TDKIASVFYTMVIPMLNPVVYSLRNKEVKNAFKKV 302
Cdd:pfam13853 241 lLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRM 276
 
Name Accession Description Interval E-value
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
23-301 3.78e-157

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 439.93  E-value: 3.78e-157
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd15407   1 IPLFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPL 182
Cdd:cd15407  81 VVFATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 LDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSS 262
Cdd:cd15407 161 LALSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSS 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 58801444 263 NHSMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNAFKK 301
Cdd:cd15407 241 SHSMDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
23-292 2.20e-150

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 422.69  E-value: 2.20e-150
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd15230   1 VPLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPL 182
Cdd:cd15230  81 AVFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 LDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSS 262
Cdd:cd15230 161 LKLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSS 240
                       250       260       270
                ....*....|....*....|....*....|
gi 58801444 263 NHSMDTDKIASVFYTMVIPMLNPVVYSLRN 292
Cdd:cd15230 241 SYSLDQDKVVSVFYTVVIPMLNPLIYSLRN 270
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
9-303 4.88e-144

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 407.52  E-value: 4.88e-144
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444   9 EFILVGLTDAPELQIPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSK 88
Cdd:cd15943   1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  89 TISLNGCAAQMFFFVAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCH 168
Cdd:cd15943  81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 169 SNVINHFFCDIPPLLDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSI 248
Cdd:cd15943 161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTI 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 58801444 249 FFGSLIFMYLQPSSNHSMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNAFKKVV 303
Cdd:cd15943 241 FYGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
10-303 2.70e-140

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 397.80  E-value: 2.70e-140
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  10 FILVGLTDAPELQIPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKT 89
Cdd:cd15410   1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  90 ISLNGCAAQMFFFVAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHS 169
Cdd:cd15410  81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 170 NVINHFFCDIPPLLDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIF 249
Cdd:cd15410 161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIF 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 58801444 250 FGSLIFMYLQPSSNHSMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNAFKKVV 303
Cdd:cd15410 241 HGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
10-296 2.33e-138

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 392.84  E-value: 2.33e-138
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  10 FILVGLTDAPELQIPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKT 89
Cdd:cd15408   1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  90 ISLNGCAAQMFFFVAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHS 169
Cdd:cd15408  81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 170 NVINHFFCDIPPLLDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIF 249
Cdd:cd15408 161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLF 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 58801444 250 FGSLIFMYLQPSSNHSMDTDKIASVFYTMVIPMLNPVVYSLRNKEVK 296
Cdd:cd15408 241 YGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
23-299 1.34e-133

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 380.26  E-value: 1.34e-133
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd15225   1 LLLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPL 182
Cdd:cd15225  81 LFLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 LDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSS 262
Cdd:cd15225 161 LKLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKS 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 58801444 263 NHSMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNAF 299
Cdd:cd15225 241 SYSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
23-292 3.73e-133

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 378.75  E-value: 3.73e-133
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd13954   1 ILLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPL 182
Cdd:cd13954  81 FSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 LDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSS 262
Cdd:cd13954 161 LKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSS 240
                       250       260       270
                ....*....|....*....|....*....|
gi 58801444 263 NHSMDTDKIASVFYTMVIPMLNPVVYSLRN 292
Cdd:cd13954 241 SYSSDLDKVVSVFYTVVTPMLNPIIYSLRN 270
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
23-301 1.01e-129

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 370.49  E-value: 1.01e-129
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd15411   1 VPLFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPL 182
Cdd:cd15411  81 IALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 LDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSS 262
Cdd:cd15411 161 LKLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSS 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 58801444 263 NHSMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNAFKK 301
Cdd:cd15411 241 SYSLGQDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
23-301 8.74e-128

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 365.86  E-value: 8.74e-128
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd15419   1 VLLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPL 182
Cdd:cd15419  81 SLFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 LDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSS 262
Cdd:cd15419 161 LKLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGA 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 58801444 263 NHSMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNAFKK 301
Cdd:cd15419 241 VSSPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
23-301 2.93e-126

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 362.02  E-value: 2.93e-126
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd15413   1 IPLFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPL 182
Cdd:cd15413  81 LTFIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 LDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSS 262
Cdd:cd15413 161 LALSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKS 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 58801444 263 NHSMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNAFKK 301
Cdd:cd15413 241 SHSLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
23-301 3.04e-125

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 359.26  E-value: 3.04e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd15417   1 IILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPL 182
Cdd:cd15417  81 SGMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 LDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSS 262
Cdd:cd15417 161 LSLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSS 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 58801444 263 NHSMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNAFKK 301
Cdd:cd15417 241 SHSQDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
10-301 2.13e-123

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 355.21  E-value: 2.13e-123
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  10 FILVGLTDAPELQIPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKT 89
Cdd:cd15945   1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  90 ISLNGCAAQMFFFVAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHS 169
Cdd:cd15945  81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 170 NVINHFFCDIPPLLDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIF 249
Cdd:cd15945 161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 58801444 250 FGSLIFMYLQPSSNHSMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNAFKK 301
Cdd:cd15945 241 YGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
14-303 2.43e-123

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 354.75  E-value: 2.43e-123
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  14 GLTDAPELQIPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLN 93
Cdd:cd15406   1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  94 GCAAQMFFFVAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVIN 173
Cdd:cd15406  81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 174 HFFCDIPPLLDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSL 253
Cdd:cd15406 161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 58801444 254 IFMYLQPSSNHSMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNAFKKVV 303
Cdd:cd15406 241 IFMYLKPSSSSSMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKVL 290
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
23-301 8.02e-121

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 348.24  E-value: 8.02e-121
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd15409   1 VPLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPL 182
Cdd:cd15409  81 GFSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 LDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSS 262
Cdd:cd15409 161 LKISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSS 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 58801444 263 NHSMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNAFKK 301
Cdd:cd15409 241 LYALDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
10-303 1.53e-120

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 347.93  E-value: 1.53e-120
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  10 FILVGLTDAPELQIPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKT 89
Cdd:cd15944   1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  90 ISLNGCAAQMFFFVAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHS 169
Cdd:cd15944  81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 170 NVINHFFCDIPPLLDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIF 249
Cdd:cd15944 161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 58801444 250 FGSLIFMYLQPSSNHSMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNAFKKVV 303
Cdd:cd15944 241 YGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
23-301 2.55e-119

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 344.38  E-value: 2.55e-119
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd15412   1 PLLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPL 182
Cdd:cd15412  81 IALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 LDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSS 262
Cdd:cd15412 161 IKLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPS 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 58801444 263 NHSMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNAFKK 301
Cdd:cd15412 241 EESVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
22-299 1.22e-116

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 337.27  E-value: 1.22e-116
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  22 QIPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFF 101
Cdd:cd15235   1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 102 FVAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPP 181
Cdd:cd15235  81 FIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 182 LLDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPS 261
Cdd:cd15235 161 LLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPS 240
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 58801444 262 SNHSMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNAF 299
Cdd:cd15235 241 SSYSADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
23-307 2.11e-116

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 337.09  E-value: 2.11e-116
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd15414   1 IPLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPL 182
Cdd:cd15414  81 GLFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 LDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSS 262
Cdd:cd15414 161 LSLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSS 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 58801444 263 NHSMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNAFKKVVERLM 307
Cdd:cd15414 241 SSSLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRRKM 285
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
25-299 6.31e-116

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 335.39  E-value: 6.31e-116
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVA 104
Cdd:cd15231   3 LFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 105 FGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLLD 184
Cdd:cd15231  83 FVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 185 ISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSSNH 264
Cdd:cd15231 163 LSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGY 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 58801444 265 SMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNAF 299
Cdd:cd15231 243 SLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
23-301 4.65e-115

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 333.61  E-value: 4.65e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd15415   1 VPLFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPL 182
Cdd:cd15415  81 AVFVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 LDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSS 262
Cdd:cd15415 161 LKLSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSS 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 58801444 263 NHSMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNAFKK 301
Cdd:cd15415 241 QYSLEQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
23-292 8.54e-115

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 332.53  E-value: 8.54e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd15912   1 ILLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPL 182
Cdd:cd15912  81 FFLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 LDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSS 262
Cdd:cd15912 161 LKLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQ 240
                       250       260       270
                ....*....|....*....|....*....|
gi 58801444 263 NHSMDTDKIASVFYTMVIPMLNPVVYSLRN 292
Cdd:cd15912 241 SSSLDLNKVVALLNTVVTPLLNPFIYTLRN 270
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
25-299 8.62e-115

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 332.59  E-value: 8.62e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVA 104
Cdd:cd15421   3 LFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 105 FGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLLD 184
Cdd:cd15421  83 LGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 185 ISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSSNH 264
Cdd:cd15421 163 LSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSYH 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 58801444 265 SMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNAF 299
Cdd:cd15421 243 SPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
23-292 2.45e-112

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 325.98  E-value: 2.45e-112
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd15911   1 ILLFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPL 182
Cdd:cd15911  81 GSLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 LDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSS 262
Cdd:cd15911 161 LKLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPST 240
                       250       260       270
                ....*....|....*....|....*....|
gi 58801444 263 NHSMDTDKIASVFYTMVIPMLNPVVYSLRN 292
Cdd:cd15911 241 NTSRDLNKVFSLFYTVLTPLVNPLIYSLRN 270
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
26-292 7.62e-112

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 324.79  E-value: 7.62e-112
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  26 FIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVAF 105
Cdd:cd15227   4 FVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 106 GAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLLDI 185
Cdd:cd15227  84 AASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 186 SCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSSNHS 265
Cdd:cd15227 164 SCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSP 243
                       250       260
                ....*....|....*....|....*..
gi 58801444 266 MDTDKIASVFYTMVIPMLNPVVYSLRN 292
Cdd:cd15227 244 SLLDLLLSVFYSVVPPTLNPIIYSLRN 270
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
23-301 1.81e-110

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 321.62  E-value: 1.81e-110
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd15416   1 IILFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPL 182
Cdd:cd15416  81 ATFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 LDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSS 262
Cdd:cd15416 161 LKLSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNS 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 58801444 263 NHSMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNAFKK 301
Cdd:cd15416 241 SYSMDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
25-292 2.51e-109

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 318.40  E-value: 2.51e-109
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVA 104
Cdd:cd15918   3 LFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 105 FGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLLD 184
Cdd:cd15918  83 FGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 185 ISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSSNH 264
Cdd:cd15918 163 LSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSH 242
                       250       260
                ....*....|....*....|....*...
gi 58801444 265 SMDTDKIASVFYTMVIPMLNPVVYSLRN 292
Cdd:cd15918 243 SASKDSVAAVMYTVVTPMLNPFIYSLRN 270
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
23-292 4.24e-108

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 315.37  E-value: 4.24e-108
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd15237   1 ILLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPL 182
Cdd:cd15237  81 LALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 LDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSS 262
Cdd:cd15237 161 LKLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHS 240
                       250       260       270
                ....*....|....*....|....*....|
gi 58801444 263 NHSMDTDKIASVFYTMVIPMLNPVVYSLRN 292
Cdd:cd15237 241 THSPDQDKMISVFYTIVTPMLNPLIYSLRN 270
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
23-292 2.72e-107

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 313.39  E-value: 2.72e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd15431   1 IILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYIS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVaLAFSLSFCHSNVINHFFCDIPPL 182
Cdd:cd15431  81 LFLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPV-LTMPLHFCGPNVINHFFCEVQAL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 LDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSS 262
Cdd:cd15431 160 LKLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQS 239
                       250       260       270
                ....*....|....*....|....*....|
gi 58801444 263 NHSMDTDKIASVFYTMVIPMLNPVVYSLRN 292
Cdd:cd15431 240 KSSSDQDKIISVFYGVVTPMLNPLIYSLRN 269
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
23-299 1.14e-106

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 312.22  E-value: 1.14e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd15229   1 IFLFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPL 182
Cdd:cd15229  81 FFFAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 LDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSS 262
Cdd:cd15229 161 LPLSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNS 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 58801444 263 NHSMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNAF 299
Cdd:cd15229 241 ASSSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
23-292 2.84e-106

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 310.73  E-value: 2.84e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd15232   1 VLLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPL 182
Cdd:cd15232  81 TWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 LDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSS 262
Cdd:cd15232 161 LLLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSS 240
                       250       260       270
                ....*....|....*....|....*....|
gi 58801444 263 NHSMDTDKIASVFYTMVIPMLNPVVYSLRN 292
Cdd:cd15232 241 SYSPEKDKVVAVLYSVVTPTLNPLIYSLRN 270
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
25-299 1.24e-103

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 304.25  E-value: 1.24e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVA 104
Cdd:cd15420   3 LFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 105 FGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLLD 184
Cdd:cd15420  83 LAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 185 ISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSSNH 264
Cdd:cd15420 163 LACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSN 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 58801444 265 SMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNAF 299
Cdd:cd15420 243 SAEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
22-302 1.46e-102

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 301.70  E-value: 1.46e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  22 QIPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFF 101
Cdd:cd15418   1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 102 FVAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPP 181
Cdd:cd15418  81 SAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 182 LLDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPS 261
Cdd:cd15418 161 LVKLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPS 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 58801444 262 SNHSMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNAFKKV 302
Cdd:cd15418 241 SSHTPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
25-299 3.76e-99

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 293.15  E-value: 3.76e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVA 104
Cdd:cd15429   3 LFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 105 FGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLLD 184
Cdd:cd15429  83 LGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVR 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 185 ISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSSNH 264
Cdd:cd15429 163 LACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGS 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 58801444 265 SMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNAF 299
Cdd:cd15429 243 SALQEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
25-292 3.15e-97

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 287.64  E-value: 3.15e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVA 104
Cdd:cd15224   3 LFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 105 FGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLLD 184
Cdd:cd15224  83 LACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLN 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 185 ISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSSNH 264
Cdd:cd15224 163 LSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAIS 242
                       250       260
                ....*....|....*....|....*...
gi 58801444 265 SMDTDKIASVFYTMVIPMLNPVVYSLRN 292
Cdd:cd15224 243 SFDSNKLVSVLYTVVTPLLNPIIYCLRN 270
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
23-292 4.66e-94

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 279.89  E-value: 4.66e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd15947   1 MPLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPL 182
Cdd:cd15947  81 LWLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 LDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSS 262
Cdd:cd15947 161 IKLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPS 240
                       250       260       270
                ....*....|....*....|....*....|
gi 58801444 263 NHSMDTDKIASVFYTMVIPMLNPVVYSLRN 292
Cdd:cd15947 241 SYSQDQGKFISLFYTVVTPTLNPLIYTLRN 270
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
23-298 8.48e-94

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 279.30  E-value: 8.48e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd15405   1 IPLFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPL 182
Cdd:cd15405  81 CFFVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 LDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSS 262
Cdd:cd15405 161 LQLSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSS 240
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 58801444 263 NHSMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNA 298
Cdd:cd15405 241 VGSVNQGKVSSVFYTNVVPMLNPLIYSLRNKDVKLA 276
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
25-298 4.04e-93

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 277.72  E-value: 4.04e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVA 104
Cdd:cd15434   3 LSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALG 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 105 FGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLLD 184
Cdd:cd15434  83 LGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALIK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 185 ISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSSNH 264
Cdd:cd15434 163 LACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNSV 242
                       250       260       270
                ....*....|....*....|....*....|....
gi 58801444 265 SMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNA 298
Cdd:cd15434 243 SQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGA 276
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
25-292 1.32e-91

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 273.32  E-value: 1.32e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVA 104
Cdd:cd15939   3 CFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 105 FGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLLD 184
Cdd:cd15939  83 FGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 185 ISCSDTHTneITLLVLATLDLVFTL--LVILNTYLLIFIAiLRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSS 262
Cdd:cd15939 163 LACTDTYV--IGLLVVANSGLICLLsfLILLISYIVILYS-LRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVT 239
                       250       260       270
                ....*....|....*....|....*....|
gi 58801444 263 NHSMdtDKIASVFYTMVIPMLNPVVYSLRN 292
Cdd:cd15939 240 TFPI--DKVVAVFYTIITPMLNPLIYTLRN 267
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
23-299 1.76e-91

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 273.59  E-value: 1.76e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd15432   1 MVLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPL 182
Cdd:cd15432  81 LGLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 LDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSS 262
Cdd:cd15432 161 LKLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPS 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 58801444 263 NHSMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNAF 299
Cdd:cd15432 241 NSSHDRGKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
25-292 3.38e-91

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 272.32  E-value: 3.38e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVA 104
Cdd:cd15430   3 LFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 105 FGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLLD 184
Cdd:cd15430  83 MGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 185 ISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSSNH 264
Cdd:cd15430 163 LACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSKN 242
                       250       260
                ....*....|....*....|....*...
gi 58801444 265 SMDTDKIASVFYTMVIPMLNPVVYSLRN 292
Cdd:cd15430 243 AQISDKLITLFYGVVTPMLNPIIYSLRN 270
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
23-298 1.39e-89

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 268.53  E-value: 1.39e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd15424   1 ILLFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPL 182
Cdd:cd15424  81 LSLGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 LDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSS 262
Cdd:cd15424 161 LKLACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRS 240
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 58801444 263 NHSMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNA 298
Cdd:cd15424 241 GSTPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGA 276
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
23-298 2.91e-89

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 267.81  E-value: 2.91e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd15428   1 ILLFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPL 182
Cdd:cd15428  81 LSFGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 LDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSS 262
Cdd:cd15428 161 LKLASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKS 240
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 58801444 263 NHSMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNA 298
Cdd:cd15428 241 STSKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHA 276
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
23-292 7.86e-87

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 261.37  E-value: 7.86e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd15226   1 LFLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPL 182
Cdd:cd15226  81 HFFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 LDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAIlRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSS 262
Cdd:cd15226 161 IKLACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTV-RKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFS 239
                       250       260       270
                ....*....|....*....|....*....|
gi 58801444 263 NHSmdTDKIASVFYTMVIPMLNPVVYSLRN 292
Cdd:cd15226 240 TFP--VDKFLAVFYTVITPLLNPIIYTLRN 267
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
25-292 1.38e-86

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 260.70  E-value: 1.38e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVA 104
Cdd:cd15915   3 LFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 105 FGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLLD 184
Cdd:cd15915  83 LGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 185 ISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRM-RSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSSN 263
Cdd:cd15915 163 LACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLLLKvRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSG 242
                       250       260
                ....*....|....*....|....*....
gi 58801444 264 HSMDTDKIASVFYTMVIPMLNPVVYSLRN 292
Cdd:cd15915 243 DSLEQDRIVALLYTVVTPVLNPLIYTLRN 271
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
24-299 8.41e-85

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 256.35  E-value: 8.41e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  24 PLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFV 103
Cdd:cd15234   2 LLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 104 AFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLL 183
Cdd:cd15234  82 LFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 184 DISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSSN 263
Cdd:cd15234 162 KLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVT 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 58801444 264 HSMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNAF 299
Cdd:cd15234 242 HSSRKTAVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
25-292 1.30e-84

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 255.76  E-value: 1.30e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVA 104
Cdd:cd15914   3 LFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 105 FGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLLD 184
Cdd:cd15914  83 LGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 185 ISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSSNH 264
Cdd:cd15914 163 LACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKSY 242
                       250       260
                ....*....|....*....|....*...
gi 58801444 265 SMDTDKIASVFYTMVIPMLNPVVYSLRN 292
Cdd:cd15914 243 SLDYDRAIAVVYAVLTPFFNPIIYSLRN 270
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
25-298 3.48e-83

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 252.41  E-value: 3.48e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVA 104
Cdd:cd15233   3 LFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 105 FGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLLD 184
Cdd:cd15233  83 LAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQ 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 185 ISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSSNH 264
Cdd:cd15233 163 LSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSVY 242
                       250       260       270
                ....*....|....*....|....*....|....
gi 58801444 265 SMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNA 298
Cdd:cd15233 243 SSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGA 276
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
23-292 3.59e-83

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 251.85  E-value: 3.59e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd15913   1 ILLFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPL 182
Cdd:cd15913  81 FSLGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 LDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSS 262
Cdd:cd15913 161 LALSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGS 240
                       250       260       270
                ....*....|....*....|....*....|
gi 58801444 263 NHSMDTDKIASVFYTMVIPMLNPVVYSLRN 292
Cdd:cd15913 241 GNSTGMQKIVTLFYSVVTPLLNPLIYSLRN 270
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
23-298 8.06e-83

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 251.21  E-value: 8.06e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLT-GSKTISLNGCAAQMFF 101
Cdd:cd15916   1 SLLFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEpGGKVISFGGCVAQLYF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 102 FVAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPP 181
Cdd:cd15916  81 FHFLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 182 LLDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPS 261
Cdd:cd15916 161 LLKLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPG 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 58801444 262 SNHSMdtDKIASVFYTMVIPMLNPVVYSLRNKEVKNA 298
Cdd:cd15916 241 SKEAL--DGVIAVFYTVVTPLLNPLIYTLRNKEVKTA 275
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
26-298 8.53e-83

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 251.23  E-value: 8.53e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  26 FIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVAF 105
Cdd:cd15236   4 FALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 106 GAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLLDI 185
Cdd:cd15236  84 GCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 186 SCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSSNHS 265
Cdd:cd15236 164 SCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNS 243
                       250       260       270
                ....*....|....*....|....*....|...
gi 58801444 266 MDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNA 298
Cdd:cd15236 244 SDKDIVASVMYTVVTPMLNPFIYSLRNRDIKGA 276
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
25-299 1.03e-82

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 251.20  E-value: 1.03e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVA 104
Cdd:cd15228   3 LFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 105 FGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLLD 184
Cdd:cd15228  83 LGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 185 ISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSSNH 264
Cdd:cd15228 163 LACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPSP 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 58801444 265 SMDTdkIASVFYTMVIPMLNPVVYSLRNKEVKNAF 299
Cdd:cd15228 243 VLVT--PVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
23-298 1.83e-81

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 247.73  E-value: 1.83e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd15942   1 APLFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPL 182
Cdd:cd15942  81 HFLGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAM 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 LDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSS 262
Cdd:cd15942 161 LKLACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGS 240
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 58801444 263 NHSMdtDKIASVFYTMVIPMLNPVVYSLRNKEVKNA 298
Cdd:cd15942 241 QDPL--DGVVAVFYTTVTPLLNPVIYTLRNKEMKDA 274
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
25-292 2.41e-79

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 242.38  E-value: 2.41e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVA 104
Cdd:cd15946   3 LFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 105 FGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLLD 184
Cdd:cd15946  83 LGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 185 ISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSSNH 264
Cdd:cd15946 163 LACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSNY 242
                       250       260
                ....*....|....*....|....*...
gi 58801444 265 SMDTDKIASVFYTMVIPMLNPVVYSLRN 292
Cdd:cd15946 243 SPERDKKISLFYNVFTALLNPVIYSLRN 270
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
24-292 1.06e-78

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 240.70  E-value: 1.06e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  24 PLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFV 103
Cdd:cd15936   2 FLFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 104 AFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLL 183
Cdd:cd15936  82 FTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 184 DISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAIlRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSSN 263
Cdd:cd15936 162 KLACTDTFLLELLMVSNSGLVTLLIFFILLISYTVILVKI-RTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQT 240
                       250       260
                ....*....|....*....|....*....
gi 58801444 264 HSMdtDKIASVFYTMVIPMLNPVVYSLRN 292
Cdd:cd15936 241 FPM--DKAVSVLYTVITPMLNPMIYTLRN 267
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
23-292 1.22e-78

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 240.42  E-value: 1.22e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd15940   1 LAFFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPL 182
Cdd:cd15940  81 HLFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 LDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAiLRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSS 262
Cdd:cd15940 161 IKLACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVS-LRKRSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPST 239
                       250       260       270
                ....*....|....*....|....*....|
gi 58801444 263 NHSMdtDKIASVFYTMVIPMLNPVVYSLRN 292
Cdd:cd15940 240 SFSE--DKVVSVFYTVVTPLLNPIIYTLRN 267
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
25-298 1.13e-75

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 233.15  E-value: 1.13e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVA 104
Cdd:cd15433   3 LFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 105 FGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLLD 184
Cdd:cd15433  83 LGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 185 ISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSSNH 264
Cdd:cd15433 163 LACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHRY 242
                       250       260       270
                ....*....|....*....|....*....|....
gi 58801444 265 SMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNA 298
Cdd:cd15433 243 SQAHGKFVSLFYTVMTPALNPLIYTLRNKDVKGA 276
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
25-299 5.67e-75

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 231.28  E-value: 5.67e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHT-PMYFFLCNLSVVDCVYASAITPKVIEGFLTGS-KTISLNGCAAQMFFF 102
Cdd:cd15941   3 FFLLFLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSgRTISFEGCVVQLYAF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPL 182
Cdd:cd15941  83 HFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 LDISCSDTHTNEitLLVLATLDLVFT--LLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQP 260
Cdd:cd15941 163 LKLACADTTINE--LVILANIGIVAAgcFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQP 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 58801444 261 SSNHSmdTDKIASVFYTMVIPMLNPVVYSLRNKEVKNAF 299
Cdd:cd15941 241 SSSQA--GAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
25-299 2.23e-71

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 222.17  E-value: 2.23e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVA 104
Cdd:cd15223   3 LSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 105 FGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLLD 184
Cdd:cd15223  83 FTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 185 ISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSSNH 264
Cdd:cd15223 163 LACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLTYRFGK 242
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 58801444 265 SMDTD--KIASVFYTMVIPMLNPVVYSLRNKEVKNAF 299
Cdd:cd15223 243 TIPPDvhVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
25-292 1.03e-68

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 215.01  E-value: 1.03e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRL-HTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFV 103
Cdd:cd15935   3 LFVLVLACYAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLH 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 104 AFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLL 183
Cdd:cd15935  83 FLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQVI 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 184 DISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIfIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSSN 263
Cdd:cd15935 163 KLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGII-LTTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFSS 241
                       250       260
                ....*....|....*....|....*....
gi 58801444 264 HSMdtDKIASVFYTMVIPMLNPVVYSLRN 292
Cdd:cd15935 242 SSV--DKVASVFYTLITPALNPLIYTLRN 268
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
25-292 4.81e-68

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 213.20  E-value: 4.81e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVA 104
Cdd:cd15938   3 LFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 105 FGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLLD 184
Cdd:cd15938  83 VGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 185 ISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIailRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSSNH 264
Cdd:cd15938 163 LACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTILV---TIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTF 239
                       250       260
                ....*....|....*....|....*...
gi 58801444 265 SmdTDKIASVFYTMVIPMLNPVVYSLRN 292
Cdd:cd15938 240 P--VDKHVSVLYNVITPMLNPLIYTLRN 265
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
25-292 2.95e-64

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 203.43  E-value: 2.95e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVA 104
Cdd:cd15937   3 LFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 105 FGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLLD 184
Cdd:cd15937  83 LGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVIK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 185 ISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIfIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSSNH 264
Cdd:cd15937 163 LACTNTYTVELLMFSNSGLVILLCFLLLLISYAFL-LAKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRSF 241
                       250       260
                ....*....|....*....|....*...
gi 58801444 265 SMdtDKIASVFYTMVIPMLNPVVYSLRN 292
Cdd:cd15937 242 PM--DKVVAVFHTVIFPLLNPMIYTLRN 267
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
27-295 1.67e-60

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 194.04  E-value: 1.67e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  27 IIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVAFG 106
Cdd:cd15917   5 IPFCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFT 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 107 AIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLLDIS 186
Cdd:cd15917  85 AMESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 187 CSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSSNHSM 266
Cdd:cd15917 165 CGDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRFGHHV 244
                       250       260       270
                ....*....|....*....|....*....|.
gi 58801444 267 --DTDKIASVFYTMVIPMLNPVVYSLRNKEV 295
Cdd:cd15917 245 ppHVHILLANLYLLLPPMLNPIVYGVRTKQI 275
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
27-295 4.40e-58

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 188.01  E-value: 4.40e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  27 IIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVAFG 106
Cdd:cd15950   5 IPFCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFT 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 107 AIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLLDIS 186
Cdd:cd15950  85 AVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 187 CSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFF-GSLIFMYLQPSSNH- 264
Cdd:cd15950 165 CADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYiPGLLSIYTQRFGQGv 244
                       250       260       270
                ....*....|....*....|....*....|.
gi 58801444 265 SMDTDKIASVFYTMVIPMLNPVVYSLRNKEV 295
Cdd:cd15950 245 PPHTQVLLADLYLLVPPMLNPIIYGMRTKQI 275
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
25-295 1.00e-55

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 181.93  E-value: 1.00e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVA 104
Cdd:cd15222   3 ISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 105 FGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILqssVHVALAF---SLSFCHSNVINHFFCDIPP 181
Cdd:cd15222  83 FSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVL---LLLPLPFllkRLPFCHSNVLSHSYCLHQD 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 182 LLDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLI------- 254
Cdd:cd15222 160 VMKLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIglsmvhr 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 58801444 255 FMYLQPSSNHSMdtdkIASVfYTMVIPMLNPVVYSLRNKEV 295
Cdd:cd15222 240 FGKHASPLVHVL----MANV-YLLVPPVLNPIIYSVKTKQI 275
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
27-295 9.45e-54

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 176.77  E-value: 9.45e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  27 IIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVAFG 106
Cdd:cd15951   5 IPFCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 107 AIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLLDIS 186
Cdd:cd15951  85 TMESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 187 CSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSSNHSM 266
Cdd:cd15951 165 CADTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLTHRFGHNV 244
                       250       260       270
                ....*....|....*....|....*....|..
gi 58801444 267 DTDK---IASVfYTMVIPMLNPVVYSLRNKEV 295
Cdd:cd15951 245 PPHVhilIANV-YLLVPPMLNPIIYGVRTKQI 275
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
29-295 4.22e-53

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 175.26  E-value: 4.22e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  29 FTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVAFGAI 108
Cdd:cd15952   7 FCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGM 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 109 ESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLLDISCS 188
Cdd:cd15952  87 ESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACA 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 189 DTHTNEITLLVLATLdLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSSNHSMD- 267
Cdd:cd15952 167 SIRINIIYGLFAISV-LVLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRFGHNIPr 245
                       250       260
                ....*....|....*....|....*....
gi 58801444 268 -TDKIASVFYTMVIPMLNPVVYSLRNKEV 295
Cdd:cd15952 246 yIHILLANLYVVLPPMLNPVIYGVRTKQI 274
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
27-295 7.30e-53

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 174.37  E-value: 7.30e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  27 IIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVAFG 106
Cdd:cd15953   5 IPFCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 107 AIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLLDIS 186
Cdd:cd15953  85 IMESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 187 CSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYL--QPSSNH 264
Cdd:cd15953 165 CGDTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLthRFGQGI 244
                       250       260       270
                ....*....|....*....|....*....|.
gi 58801444 265 SMDTDKIASVFYTMVIPMLNPVVYSLRNKEV 295
Cdd:cd15953 245 APHIHIILANLYLLVPPMLNPIIYGVKTKEI 275
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
27-295 5.29e-51

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 169.78  E-value: 5.29e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  27 IIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVAFG 106
Cdd:cd15221   5 IPFCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 107 AIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLLDIS 186
Cdd:cd15221  85 VTESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 187 CSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQ------- 259
Cdd:cd15221 165 CADITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLThrfgrhi 244
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 58801444 260 PSSNHSMdtdkIASVfYTMVIPMLNPVVYSLRNKEV 295
Cdd:cd15221 245 PRHVHIL----LANL-YVLVPPMLNPIVYGVKTKQI 275
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
8-296 3.02e-49

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 165.72  E-value: 3.02e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444   8 TEFILVGLTDAPELQIPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGS 87
Cdd:cd15949   2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  88 KTISLNGCAAQMFFFVAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFC 167
Cdd:cd15949  82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 168 HSNVINHFFCDIPPLLDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVS 247
Cdd:cd15949 162 RTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAIL 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 58801444 248 IFF-----GSLIFMYLQPSSNHsmdTDKIASVFYTMVIPMLNPVVYSLRNKEVK 296
Cdd:cd15949 242 AFYvpiavSSLIHRFGQNVPPP---THILLANFYLLIPPMLNPIVYGVRTKQIQ 292
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
25-295 2.48e-45

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 155.02  E-value: 2.48e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVA 104
Cdd:cd15956   3 LSLPFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 105 FGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLLD 184
Cdd:cd15956  83 FSAMESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 185 ISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSSNH 264
Cdd:cd15956 163 LACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRFGH 242
                       250       260       270
                ....*....|....*....|....*....|...
gi 58801444 265 SMDTDK--IASVFYTMVIPMLNPVVYSLRNKEV 295
Cdd:cd15956 243 SVPSAAhvLLSNLYLLLPPALNPIVYGIRTKQI 275
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
27-296 4.86e-45

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 154.29  E-value: 4.86e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  27 IIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVAFG 106
Cdd:cd15948   6 IPFCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 107 AIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLLDIS 186
Cdd:cd15948  86 IMESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLA 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 187 CSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFF-----GSLIFMYLQPS 261
Cdd:cd15948 166 CGDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYtpvvlSSTMHRFARHV 245
                       250       260       270
                ....*....|....*....|....*....|....*
gi 58801444 262 SNHsmdTDKIASVFYTMVIPMLNPVVYSLRNKEVK 296
Cdd:cd15948 246 APH---VHILLANFYLLFPPMMNPIVYGVKTKQIR 277
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
29-302 1.28e-43

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 150.73  E-value: 1.28e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444    29 FTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVAFGAI 108
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444   109 ESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLLDISCS 188
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444   189 DTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSSNHSMD- 267
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPp 240
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 58801444   268 -TDKIASVFYTMVIPMLNPVVYSLRNKEVKNAFKKV 302
Cdd:pfam13853 241 lLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRM 276
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
27-295 8.35e-42

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 145.74  E-value: 8.35e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  27 IIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVAFG 106
Cdd:cd15954   5 IPFCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFT 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 107 AIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPLLDIS 186
Cdd:cd15954  85 GMESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 187 CSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQ---PSSN 263
Cdd:cd15954 165 CANIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAhrfGGHH 244
                       250       260       270
                ....*....|....*....|....*....|..
gi 58801444 264 HSMDTDKIASVFYTMVIPMLNPVVYSLRNKEV 295
Cdd:cd15954 245 ITPHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
27-295 3.95e-38

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 136.44  E-value: 3.95e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  27 IIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVAFG 106
Cdd:cd15955   5 IPFCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQ 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 107 AIESLILASMAYDRHAAVCKPLHYTTIMTS---TTCILIVTWCYTCGILQSSVHVALafSLSFCHSNVINHFFCDIPPLL 183
Cdd:cd15955  85 AFESGILLAMALDRYVAICHPLRHSSILTPqvlLGIGVLVVVRAVVLIIPCPLLIKL--RLHHFRSTVISHSYCEHMAVV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 184 DISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQPSSN 263
Cdd:cd15955 163 KLAADDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHRFG 242
                       250       260       270
                ....*....|....*....|....*....|....
gi 58801444 264 HSMD--TDKIASVFYTMVIPMLNPVVYSLRNKEV 295
Cdd:cd15955 243 HHVApyVHILLSNLYLLVPPVLNPIVYGVKTKQI 276
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
39-288 1.46e-30

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 115.86  E-value: 1.46e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444    39 GNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLT-GSKTISLNGCAAQMFFFVAFGAIESLILASMA 117
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444   118 YDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSlsfCHSNVINHFFCDIPPLLDISCSDTHTNEITL 197
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWT---LTVPEGNVTVCFIDFPEDLSKPVSYTLLISV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444   198 LVlatldLVFTLLVILNTYLLIFIAILRMRSAEAQ-------RKAFSTCASHLITVSIFFGSLIFMYLQPS----SNHSM 266
Cdd:pfam00001 158 LG-----FLLPLLVILVCYTLIIRTLRKSASKQKSsertqrrRKALKTLAVVVVVFILCWLPYHIVNLLDSlaldCELSR 232
                         250       260
                  ....*....|....*....|....
gi 58801444   267 DTDKIASV--FYTMVIPMLNPVVY 288
Cdd:pfam00001 233 LLDKALSVtlWLAYVNSCLNPIIY 256
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
25-292 1.35e-19

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 86.57  E-value: 1.35e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVA 104
Cdd:cd00637   1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 105 FGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIV--TWCYTCgilqssvhvaLAFSLSFCHSNVINHFFCDIPPL 182
Cdd:cd00637  81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIalIWLLSL----------LLALPPLLGWGVYDYGGYCCCCL 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 ldiSCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILR--------------MRSAEAQRKAFSTCashLITVSI 248
Cdd:cd00637 151 ---CWPDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRhrrrirssssnssrRRRRRRERKVTKTL---LIVVVV 224
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 58801444 249 FFGS-------LIFMYLQPSSNHSMDTDKIASVFYTMVIPMLNPVVYSLRN 292
Cdd:cd00637 225 FLLCwlpyfilLLLDVFGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
25-299 9.19e-17

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 78.37  E-value: 9.19e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVA 104
Cdd:cd14967   2 LAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 105 FGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHValafslsfchsnVINHFFCDIPPllD 184
Cdd:cd14967  82 CCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPL------------VGWRDETQPSV--V 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 185 ISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRmrsaeaQRKAFSTCAshlITVSIFFG-----SLIFMYLQ 259
Cdd:cd14967 148 DCECEFTPNKIYVLVSSVISFFIPLLIMIVLYARIFRVARR------ELKAAKTLA---IIVGAFLLcwlpfFIIYLVSA 218
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 58801444 260 PSSNHSMDTDKIASVFYTMVI-PMLNPVVYSLRNKEVKNAF 299
Cdd:cd14967 219 FCPPDCVPPILYAVFFWLGYLnSALNPIIYALFNRDFRRAF 259
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
25-172 2.75e-10

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 60.06  E-value: 2.75e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKviegfltgSKTISLNGCaaqMFFFVA 104
Cdd:cd15312   3 MYLFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPY--------SMVRSVESC---WYFGDL 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 105 FGAIESLI-----------LASMAYDRHAAVCKPLHYTTIMTSTTCI--LIVTWCYTCgilqssvhvALAFSLSFCHSNV 171
Cdd:cd15312  72 FCKIHSSLdmmlsttsifhLCFIAVDRYYAVCDPLHYRTKITTPVIKvfLVISWSVPC---------LFAFGVVFSEVNL 142

                .
gi 58801444 172 I 172
Cdd:cd15312 143 E 143
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
27-299 5.00e-10

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 59.14  E-value: 5.00e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  27 IIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMfFFVAFG 106
Cdd:cd14969   5 VYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYG-FAVTFL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 107 AIESLI-LASMAYDRHAAVCKPLHYTTIMTSTTCILI-VTWCYTcgilqssvhvalafslsfchsnvinhFFCDIPPLL- 183
Cdd:cd14969  84 GLVSIStLAALAFERYLVIVRPLKAFRLSKRRALILIaFIWLYG--------------------------LFWALPPLFg 137
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 184 ---------DISCS----DTHTNEIT-LLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLIT---- 245
Cdd:cd14969 138 wssyvpeggGTSCSvdwySKDPNSLSyIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNSAITKRTKKAekkv 217
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 58801444 246 -------VSIFFG--------SLIFMYLQPSSNHSmdtdkiasvfYTMVIP--------MLNPVVYSLRNKEVKNAF 299
Cdd:cd14969 218 akmvlvmIVAFLIawtpyavvSLYVSFGGESTIPP----------LLATIPalfaksstIYNPIIYVFMNKQFRRAL 284
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
26-166 1.20e-08

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 55.34  E-value: 1.20e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  26 FIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSK-TISLNGCAAQMFFFVA 104
Cdd:cd15217   4 LVLLGLIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSIRNGSAwTYSVLSCKIVAFMAVL 83
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 58801444 105 FGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTcgilqssVHVALAFSLSF 166
Cdd:cd15217  84 FCFHAAFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWT-------LSVAMAFPPVF 138
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
27-299 3.80e-08

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 53.45  E-value: 3.80e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  27 IIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVyASAITpkviegFLTGSKTISLNGCAAQMFFFVAFG 106
Cdd:cd14972   3 VVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLL-AGIAF------VFTFLSVLLVSLTPSPATWLLRKG 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 107 AIESLILAS------MAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILqssvhVALAFSLSFchsnviNHFFCDIP 180
Cdd:cd14972  76 SLVLSLLASaysllaIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVL-----LALLPVLGW------NCVLCDQE 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 181 plldiSCSDT----HTNEITLLVLATLdLVFTLLVILNTYLLIFI---AILRMRSAEAQRKAF-STCASHLITVSIFFGS 252
Cdd:cd14972 145 -----SCSPLgpglPKSYLVLILVFFF-IALVIIVFLYVRIFWCLwrhANAIAARQEAAVPAQpSTSRKLAKTVVIVLGV 218
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 58801444 253 LIFMYLQPSSNHSMDT-----DKIASVFYTMVIPML-----NPVVYSLRNKEVKNAF 299
Cdd:cd14972 219 FLVCWLPLLILLVLDVlcpsvCDIQAVFYYFLVLALlnsaiNPIIYAFRLKEMRRAV 275
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
25-232 4.52e-08

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 53.33  E-value: 4.52e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITP----KVIEGFLTGSKTIslngCAAQMF 100
Cdd:cd15055   3 LYIVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMPfsmiRSIETCWYFGDTF----CKLHSS 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 101 FFVAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVhvalafsLSFCHSNVINHFFcdip 180
Cdd:cd15055  79 LDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSV-------LLYDNLNQPGLIR---- 147
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 58801444 181 pllDISCSDthtnEITLLVLA---TLDLVFTLL----VILNTYLLIFIAILR----MRSAEAQ 232
Cdd:cd15055 148 ---YNSCYG----ECVVVVNFiwgVVDLVLTFIlpctVMIVLYMRIFVVARSqaraIRSHTAQ 203
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
30-154 1.72e-07

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 52.07  E-value: 1.72e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  30 TLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTI-SLNGCAAQMFFFVAFGAI 108
Cdd:cd15005   8 GLILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIyGALSCKVIAFLAVLFCFH 87
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 58801444 109 ESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQS 154
Cdd:cd15005  88 SAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMA 133
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
27-241 4.56e-07

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 50.32  E-value: 4.56e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  27 IIFTLIYLIALFGNLgMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQ-----MFF 101
Cdd:cd14978   5 YVLPVICIFGIIGNI-LNLVVLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYflpyiYPL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 102 FVAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPP 181
Cdd:cd14978  84 ANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVIPTL 163
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 182 LLDISCSDTHTNEITLLVLATLdLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCAS 241
Cdd:cd14978 164 LRQNETYLLKYYFWLYAIFVVL-LPFILLLILNILLIRALRKSKKRRRLLRRRRRLLSRS 222
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
26-299 6.31e-07

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 49.99  E-value: 6.31e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  26 FIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVAF 105
Cdd:cd15390   4 SIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAITT 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 106 GAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFCDIPPlldi 185
Cdd:cd15390  84 VAASVFTLMAISIDRYIAIVHPLRPRLSRRTTKIAIAVIWLASFLLALPQLLYSTTETYYYYTGSERTVCFIAWPD---- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 186 sCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAI-----------LRMRSAEAQRKAFSTCAshlITVSIF----- 249
Cdd:cd15390 160 -GPNSLQDFVYNIVLFVVTYFLPLIIMAVAYTRVGVELwgsktigentpRQLESVRAKRKVVKMMI---VVVVIFaicwl 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 58801444 250 --FGSLIFMYLQPSSNHSMDTDKIASVFY--TMVIPMLNPVVYSLRNKEVKNAF 299
Cdd:cd15390 236 pyHLYFILTYLYPDINSWKYIQQIYLAIYwlAMSNSMYNPIIYCWMNKRFRYGF 289
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
25-299 1.02e-06

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 49.52  E-value: 1.02e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVA 104
Cdd:cd14993   3 LIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQGV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 105 FGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTC--ILIVTWCYTCGILQSSVHVALAFSLSFCHSNVINHFFC--DIP 180
Cdd:cd14993  83 SVSASVLTLVAISIDRYLAICYPLKARRVSTKRRAriIIVAIWVIAIIIMLPLLVVYELEEIISSEPGTITIYICteDWP 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 181 PLldiscSDTHTNEITLLVLAtldLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASH------------LITVSI 248
Cdd:cd14993 163 SP-----ELRKAYNVALFVVL---YVLPLLIISVAYSLIGRRLWRRKPPGDRGSANSTSSRRilrskkkvarmlIVVVVL 234
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 58801444 249 FFGS-----LIFMYLQPSSnhsmDTDKIASVFYTMVIPML----------NPVVYSLRNKEVKNAF 299
Cdd:cd14993 235 FALSwlpyyVLSILLDFGP----LSSEESDENFLLILPFAqllgysnsaiNPIIYCFMSKKFRRGF 296
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
25-145 2.19e-06

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 48.27  E-value: 2.19e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVA 104
Cdd:cd15202   3 LIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYC 82
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 58801444 105 FGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTW 145
Cdd:cd15202  83 SVHVSAYTLTAIAVDRYQAIMHPLKPRISKTKAKFIIAVIW 123
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
31-303 4.37e-06

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 47.25  E-value: 4.37e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  31 LIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVAFGAIES 110
Cdd:cd15307   9 VLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCTASI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 111 LILASMAYDRHAAVCKPLHYTTIMTSTTCIL--IVTWCYTcgiLQSSVHVALAFSLSfcHSNVINHFFCDIPplldiscs 188
Cdd:cd15307  89 MHLCTISVDRYLSLRYPMRFGRNKTRRRVTLkiVFVWLLS---IAMSLPLSLMYSKD--HASVLVNGTCQIP-------- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 189 dthtNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEA-----QRKAFSTCASHLITVSIFFGSLIFMYLQPSSN 263
Cdd:cd15307 156 ----DPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRSRHGriirlEQKATKVLGVVFFTFVILWSPFFVLNLLPTVC 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 58801444 264 HSMDtDKIASVFYTMVI------PMLNPVVYSLRNKEVKNAFKKVV 303
Cdd:cd15307 232 AECE-ERISHWVFDVVTwlgyasSMVNPIFYTIFNKVFRQAFKKVL 276
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
23-146 4.97e-06

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 47.24  E-value: 4.97e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKviegfltgSKTISLNGCaaqMFFF 102
Cdd:cd15314   1 VLLYIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPP--------SMVRSVETC---WYFG 69
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 58801444 103 VAFGAIES-----------LILASMAYDRHAAVCKPLHYTTIMT-STTCILI-VTWC 146
Cdd:cd15314  70 DLFCKIHSsfditlctasiLNLCFISIDRYYAVCQPLLYRSKITvRVVLVMIlISWS 126
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
23-299 5.79e-06

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 47.04  E-value: 5.79e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAA--QMF 100
Cdd:cd15050   1 APLGIALSTISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFwlSMD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 101 FFVAFGAIESLILASMayDRHAAVCKPLHYTTIMTSTtcilivtwcytcgilQSSVHVALAFSLSFCHSNVI---NHFFC 177
Cdd:cd15050  81 YVASTASIFSLFILCI--DRYRSVQQPLKYLKYRTKT---------------RASLMISGAWLLSFLWVIPIlgwHHFAR 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 178 DIPPLLDISCSDT--HTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAeAQRKAFSTCASHLITVSIFFGSLIF 255
Cdd:cd15050 144 GGERVVLEDKCETdfHDVTWFKVLTAILNFYIPSLLMLWFYAKIFKAVNRERKA-AKQLGFIMAAFILCWIPYFILFMVI 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 58801444 256 MYLQPSSNHSMdtdKIASVFYTMVIPMLNPVVYSLRNKEVKNAF 299
Cdd:cd15050 223 AFCKNCCNENL---HMFTIWLGYINSTLNPFIYPLCNENFKKTF 263
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
24-162 6.00e-06

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 46.96  E-value: 6.00e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  24 PLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFV 103
Cdd:cd15065   1 LIGIFLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDV 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 58801444 104 AFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAF 162
Cdd:cd15065  81 MCSTASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFLPIHLGW 139
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
27-299 7.27e-06

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 46.50  E-value: 7.27e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  27 IIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSK-TISLNGCAAQMFFFVAF 105
Cdd:cd15310   5 LSYCALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVwNFSRICCDVFVTLDVMM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 106 GAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSLSfchsnvinhfFCDIPPLLDI 185
Cdd:cd15310  85 CTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVSLMITAVWVLAFAVSCPLLFGFN----------TTGDPTVCSI 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 186 ScsdthtNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQrkafstcashlitVSIFFGSLIFMYLQPSSNHS 265
Cdd:cd15310 155 S------NPDFVIYSSVVSFYLPFGVTLLVYVRIYVVLLREKKATQM-------------LAIVLGAFIVCWLPFFLTHI 215
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 58801444 266 MDTD----------KIASVFYTMVIPMLNPVVYSLRNKEVKNAF 299
Cdd:cd15310 216 LNTHcqachvppelYSATTWLGYVNSALNPVIYTTFNIEFRRAF 259
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
24-151 8.77e-06

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 46.66  E-value: 8.77e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  24 PLFI-IFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPkviegfLTGSKTISLNGCAAQMF-- 100
Cdd:cd15394   1 PLIIpLYSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVP------LTLAYAFEPRGWVFGRFmc 74
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 58801444 101 FFVAFGA-----IESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGI 151
Cdd:cd15394  75 YFVFLMQpvtvyVSVFTLTAIAVDRYYVTVYPLRRRISRRTCAYIVAAIWLLSCGL 130
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
27-143 2.04e-05

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 45.44  E-value: 2.04e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  27 IIFTLIYLIALFGNLGMIILILLDSRL-HTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVAF 105
Cdd:cd15104   4 VILAVLSPLIITGNLLVIVALLKLIRKkDTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFVITS 83
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 58801444 106 GAIESLILASMAYDRHAAVCKPLHYTTIMT-STTCILIV 143
Cdd:cd15104  84 CAASVLSLAAIAFDRYLALKQPLRYKQIMTgKSAGALIA 122
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
28-145 3.70e-05

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 44.53  E-value: 3.70e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  28 IFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVAFGA 107
Cdd:cd15321  12 AITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALDVLFCT 91
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 58801444 108 IESLILASMAYDRHAAVCKPLHYTTIMT--STTCILIVTW 145
Cdd:cd15321  92 SSIVHLCAISLDRYWSVSRAIEYNSKRTprRIKCIILIVW 131
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
28-152 3.98e-05

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 44.54  E-value: 3.98e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  28 IFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVAFGA 107
Cdd:cd15354   6 VFLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHLVIEDAFVRHIDNVFDSL 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 58801444 108 IESLILASM------AYDRHAAVCKPLHYTTIMTSTTCILIV----TWCYTCGIL 152
Cdd:cd15354  86 ICISVVASMcsllaiAVDRYVTIFYALRYHNIMTVRRAGIIIaciwTFCTGCGII 140
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
27-149 4.52e-05

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 44.30  E-value: 4.52e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  27 IIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDC-VYASAITPKVIEGFLTGSKTI-SLNGCAAQMFF-FV 103
Cdd:cd14995   5 FLVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLmVLVAAGLPNEIESLLGPDSWIyGYAGCLLITYLqYL 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 58801444 104 AFGAiESLILASMAYDRHAAVCKPLHYTTIMT--STTCILIVTWCYTC 149
Cdd:cd14995  85 GINA-SSLSITAFTIERYIAICHPMKAQFICTvsRAKKIICFVWIFTS 131
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
27-152 5.26e-05

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 44.09  E-value: 5.26e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  27 IIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVD---CVYASAIT--PKVIEGFLTGSKTislngCAAQMFF 101
Cdd:cd15978   5 LLYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDlmlCLFCMPFTliPNLLKDFIFGSAV-----CKTATYF 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 58801444 102 FVAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIV--TWCYTCGIL 152
Cdd:cd15978  80 MGISVSVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIaaTWCLSFTIM 132
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
27-128 5.55e-05

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 44.03  E-value: 5.55e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  27 IIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVAFG 106
Cdd:cd15979   5 LLYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSV 84
                        90       100
                ....*....|....*....|..
gi 58801444 107 AIESLILASMAYDRHAAVCKPL 128
Cdd:cd15979  85 SVSTFSLVAIAIERYSAICNPL 106
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
27-299 6.26e-05

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 43.86  E-value: 6.26e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  27 IIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVAFG 106
Cdd:cd15064   5 VLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLDVTCC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 107 AIESLILASMAYDRHAAVCKPLHYTTIMTSTTcilivtwcytcgilqSSVHVALAFSLSFCHSnvinhffcdIPPLLDIS 186
Cdd:cd15064  85 TASILHLCVIALDRYWAITDAVEYAHKRTPKR---------------AAVMIALVWTLSICIS---------LPPLFGWR 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 187 CSDTHT-------NEITLLVLATLDLVFT-LLVILNTYLLIFiailrmRSAEAQRKAFStcashliTVSIFFGSLIFMYL 258
Cdd:cd15064 141 TPDSEDpseclisQDIGYTIFSTFGAFYIpLLLMLILYWKIY------RAAARERKAAK-------TLGIILGAFIVCWL 207
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 58801444 259 --------QPSSNHSMDTDKIASVFYTM--VIPMLNPVVYSLRNKEVKNAF 299
Cdd:cd15064 208 pfflvaliVPLCSHCWIPLALKSFFLWLgyFNSLINPLIYTFFNKDFRKAF 258
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
25-148 8.35e-05

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 43.33  E-value: 8.35e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNlGMIILILLDSR-LHTPMYFFLCNLSVVDCVYASAiTPKVIEGFLTGSKTISLNGCAAQMFFFV 103
Cdd:cd15079   3 LGFIYIFLGIVSLLGN-GLVIYIFSTTKsLRTPSNMLVVNLAISDFLMMIK-MPIFIYNSFYEGWALGPLGCQIYAFLGS 80
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 58801444 104 AFGAIESLILASMAYDRHAAVCKPLHYTTiMTSTTCILIV--TWCYT 148
Cdd:cd15079  81 LSGIGSIWTNAAIAYDRYNVIVKPLNGNP-LTRGKALLLIlfIWLYA 126
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
23-135 1.10e-04

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 43.20  E-value: 1.10e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVD-----CVYASAITPKVIEGFLTGSKTISLNGCAA 97
Cdd:cd15317   1 VIIYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADfllglCVMPFSMIRTVETCWYFGDLFCKFHTGLD 80
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 58801444  98 QMFFFVAFgaiesLILASMAYDRHAAVCKPLHYTTIMT 135
Cdd:cd15317  81 LLLCTTSI-----FHLCFIAIDRYYAVCDPLRYPSKIT 113
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
23-299 1.16e-04

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 43.01  E-value: 1.16e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVD-CVYASAItPKVIegFLTGSKTISLNGCAAQMFF 101
Cdd:cd14968   1 AVYIVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADiLVGALAI-PLAI--LISLGLPTNFHGCLFMACL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 102 FVAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGIL-----------QSSVHVALAFSLSFCH-S 169
Cdd:cd14968  78 VLVLTQSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLvgltpmfgwnnGAPLESGCGEGGIQCLfE 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 170 NVI--------NHFFCDIPPlldiscsdthtneitllvlatldlvftLLVILNTYLLIFIAILR-----------MRSAE 230
Cdd:cd14968 158 EVIpmdymvyfNFFACVLVP---------------------------LLIMLVIYLRIFRVIRKqlrqiesllrsRRSRS 210
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 231 AQRKAFSTCASHLITVSIFFGSLI-------FMYLQPSSNhsmdtdKIASVFYTMVI-----PMLNPVVYSLRNKEVKNA 298
Cdd:cd14968 211 TLQKEVKAAKSLAIILFLFALCWLplhiincITLFCPECK------VPKILTYIAILlshanSAVNPIVYAYRIRKFRQT 284

                .
gi 58801444 299 F 299
Cdd:cd14968 285 F 285
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
23-238 1.53e-04

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 42.73  E-value: 1.53e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVD-CVYASAITPKVIEGFLTGSKTISLNGCAAQMFF 101
Cdd:cd14979   1 VLVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDlLILLVGLPVELYNFWWQYPWAFGDGGCKLYYFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 102 FVAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQS---SVHVALAFSLSFCHSNVINHFFCD 178
Cdd:cd14979  81 FEACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAipiLFLMGIQYLNGPLPGPVPDSAVCT 160
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 179 IPPlldiscsDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFST 238
Cdd:cd14979 161 LVV-------DRSTFKYVFQVSTFIFFVLPMFVISILYFRIGVKLRSMRNIKKGTRAQGT 213
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
23-145 1.91e-04

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 42.29  E-value: 1.91e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVD-CVYASAItPKVIEGFLTGSKTISLNGCAAQMFF 101
Cdd:cd15048   1 IVLAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADfLVGLVSM-PFYIPYTLTGKWPFGKVFCKAWLVV 79
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 58801444 102 FVAFGAIESLILASMAYDRHAAVCKPLHYTTIMTS--TTCILIVTW 145
Cdd:cd15048  80 DYTLCTASALTIVLISLDRYLSVTKAVKYRAKQTKrrTVLLMALVW 125
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
28-148 1.92e-04

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 42.20  E-value: 1.92e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  28 IFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVAFGA 107
Cdd:cd15353   6 VFVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVVITLLNGNDTDAQSFTVNIDNVIDSVI 85
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 58801444 108 IESLI-----LASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYT 148
Cdd:cd15353  86 CSSLLasicsLLSIAVDRYFTIFYALQYHNIMTVRRAGVIITCIWT 131
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
25-145 2.01e-04

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 42.32  E-value: 2.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVA 104
Cdd:cd15389   3 LIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQYC 82
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 58801444 105 FGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTW 145
Cdd:cd15389  83 SVYVSTLTLTAIALDRHRVILHPLKPRITPCQGVVVIAIIW 123
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
28-225 2.31e-04

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 42.20  E-value: 2.31e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  28 IFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCA--AQMFFFVAF 105
Cdd:cd15959   6 LLSLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCElwTSVDVLCVT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 106 GAIESliLASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYtcgilqssvhvALAFSLSFchSNVINHFFCDIPPLLDI 185
Cdd:cd15959  86 ASIET--LCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVW-----------AISAAISF--LPIMNQWWRDGADEEAQ 150
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 58801444 186 SCSDTH------TNEITLLVLATLDLVFTLLVILNTYLLIFIAILR 225
Cdd:cd15959 151 RCYDNPrccdfvTNMPYAIVSSTVSFYVPLLVMIFVYVRVFVVATR 196
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
28-146 2.98e-04

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 41.59  E-value: 2.98e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  28 IFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVAFGA 107
Cdd:cd15066   5 AMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNSLDVYFST 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 58801444 108 IESLILASMAYDRHAAVCKPLHYTTIMTSTTC--ILIVTWC 146
Cdd:cd15066  85 ASILHLCCISVDRYYAIVQPLEYPSKMTKRRVaiMLANVWI 125
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
25-259 3.01e-04

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 41.64  E-value: 3.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVA 104
Cdd:cd14964   1 TTIILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 105 FGAIESLILASMAYDRHAAVCKPLHYTTIMTSTtcilivtwcytcgilQSSVHVALAFSLSFCHSNVINHFFCDIPPLLD 184
Cdd:cd14964  81 ANLASIWTTLVLTYHRYFALCGPLKYTRLSSPG---------------KTRVIILGCWGVSLLLSIPPLVGKGAIPRYNT 145
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 58801444 185 ISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFGSLIFMYLQ 259
Cdd:cd14964 146 LTGSCYLICTTIYLTWGFLLVSFLLPLVAFLVIFSRIVLRLRRRVRAIRSAASLNTDKNLKATKSLLILVITFLL 220
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
20-128 3.37e-04

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 41.61  E-value: 3.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  20 ELQIPLFiifTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVD---CVYASAIT--PKVIEGFLTGSKTislng 94
Cdd:cd15206   1 ELIIPLY---SVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDlllAVFCMPFTlvGQLLRNFIFGEVM----- 72
                        90       100       110
                ....*....|....*....|....*....|....
gi 58801444  95 CAAQMFFFVAFGAIESLILASMAYDRHAAVCKPL 128
Cdd:cd15206  73 CKLIPYFQAVSVSVSTFTLVAISLERYFAICHPL 106
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
27-146 3.65e-04

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 41.45  E-value: 3.65e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  27 IIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYA-SAITPKVI----EGFLTGSKTislngCAAQMFF 101
Cdd:cd15196   5 AVLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVAlFNVLPQLIwditYRFYGGDLL-----CRLVKYL 79
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 58801444 102 FVAFGAIESLILASMAYDRHAAVCKPL-HYTTIMTSTTCILIVTWC 146
Cdd:cd15196  80 QVVGMYASSYVLVATAIDRYIAICHPLsSHRWTSRRVHLMVAIAWV 125
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
28-255 3.87e-04

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 41.30  E-value: 3.87e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  28 IFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVI------EGFLT--GSKTISLNGCAAQM 99
Cdd:cd15350   6 VFFTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYKTLENIliiladMGYLNrrGPFETKLDDIMDSL 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 100 FFFVAFGAIESLIlaSMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTcgilqssvhvalafslsfchsnvinhfFCDI 179
Cdd:cd15350  86 FCLSLLGSIFSIL--AIAADRYITIFHALRYHNIMTMRRTLVILAIIWT---------------------------FCGG 136
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 58801444 180 PPLLDISCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIFI---AILRMRSAEAQRKafSTCASHLITVSIFFGSLIF 255
Cdd:cd15350 137 SGILMILFFHFVATVICFTVLFFLMLVLILCLYVHMFLLARSharKIASLPNHHAQHQ--RSNMRGAITLTILLGVFVC 213
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
27-149 5.79e-04

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 40.72  E-value: 5.79e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  27 IIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVAFG 106
Cdd:cd15074   5 IYLTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFG 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 58801444 107 AIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIV-TWCYTC 149
Cdd:cd15074  85 CCSINTLTAISIYRYLKICHPPYGPKLSRRHVCIVIVaIWLYAL 128
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
23-143 6.64e-04

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 40.67  E-value: 6.64e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVD---CVYASAITPkvIEGFltgSKTISLNGCAAQM 99
Cdd:cd15203   1 IILILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDlllCLVSLPFTL--IYTL---TKNWPFGSILCKL 75
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 58801444 100 FFFVAFGAI--ESLILASMAYDRHAAVCKPLHytTIMTSTTCILIV 143
Cdd:cd15203  76 VPSLQGVSIfvSTLTLTAIAIDRYQLIVYPTR--PRMSKRHALLII 119
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
27-145 6.66e-04

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 40.68  E-value: 6.66e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  27 IIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVA-- 104
Cdd:cd16003   5 LAYGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHSEWYFGEAYCRFHNFFPITsv 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 58801444 105 FGAIESliLASMAYDRHAAVCKPLHYTTIMTSTTCILIVTW 145
Cdd:cd16003  85 FASIYS--MTAIAVDRYMAIIDPLKPRLSATATKVVIGSIW 123
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
34-147 6.73e-04

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 40.61  E-value: 6.73e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  34 LIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVAFGAIESLIL 113
Cdd:cd15085  12 TFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQGFAVNYFGIVSLWSL 91
                        90       100       110
                ....*....|....*....|....*....|....*
gi 58801444 114 ASMAYDRHAAVCKPLHYTTIMTSTTC-ILIVTWCY 147
Cdd:cd15085  92 TLLAYERYNVVCKPMGGLKLSTKRGYqGLLFIWLF 126
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
25-154 7.06e-04

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 40.42  E-value: 7.06e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTI-SLNGCAAQMFFFV 103
Cdd:cd15067   2 LGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTGGYWLfGRDWCDVWHSFDV 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 58801444 104 AFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQS 154
Cdd:cd15067  82 LASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALIS 132
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
25-236 7.19e-04

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 40.51  E-value: 7.19e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGC----AAQMF 100
Cdd:cd15058   3 LLLLLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCelwtSVDVL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 101 FFVAfgAIESliLASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHVALAFSlsfcHSNVINHFFCDIP 180
Cdd:cd15058  83 CVTA--SIET--LCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVSFVPIMNQWW----RANDPEANDCYQD 154
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 58801444 181 PlldiSCSDTHTNEITLLVLATLDLVFTLLVILNTYLLIF-IAILRMRSAEAQRKAF 236
Cdd:cd15058 155 P----TCCDFRTNMAYAIASSVVSFYIPLLIMIFVYARVFlIATRQLQLIDKRRLRF 207
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
31-155 9.59e-04

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 40.35  E-value: 9.59e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  31 LIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVD------CVYASAITPKVIEGFLTGSKTislngCAAQMFFFVA 104
Cdd:cd14997   9 VIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADllvllvCMPVALVETWAREPWLLGEFM-----CKLVPFVELT 83
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 58801444 105 FGAIESLILASMAYDRHAAVCKPLH--YTTIMTSTTCILIVTWcyTCGILQSS 155
Cdd:cd14997  84 VAHASVLTILAISFERYYAICHPLQakYVCTKRRALVIIALIW--LLALLTSS 134
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
28-152 1.68e-03

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 39.39  E-value: 1.68e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  28 IFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISlngcAAQMFFFVAFGA 107
Cdd:cd15103   6 VFLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLV----PRDSFEQHIDNV 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 58801444 108 IESLILASM----------AYDRHAAVCKPLHYTTIMT--STTCILIVTW--CYTCGIL 152
Cdd:cd15103  82 IDSMICSSLlasicsllaiAVDRYITIFYALRYHSIMTvrRAGVIITAIWvfCTVCGIL 140
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
23-71 2.02e-03

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 39.24  E-value: 2.02e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVY 71
Cdd:cd15134   1 IPITIIYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLL 49
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
24-75 2.09e-03

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 38.96  E-value: 2.09e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 58801444  24 PLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVD------CVYASAI 75
Cdd:cd15012   1 IFIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADlcvgifCVLQNLS 58
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
27-234 2.18e-03

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 39.20  E-value: 2.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  27 IIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFV--A 104
Cdd:cd15096   5 VIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYvtA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 105 FGAIESLILasMAYDRHAAVCKPLHYTTIMTS-TTCILIV-TWCYtcgILQSSVHVALAFSLSFCHSNVINHFFCDIppl 182
Cdd:cd15096  85 YASVYTLVL--MSLDRYLAVVHPITSMSIRTErNTLIAIVgIWIV---ILVANIPVLFLHGVVSYGFSSEAYSYCTF--- 156
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 58801444 183 LDISCSDTHTNEITLLVLAtldLVFTLLVILNTYLLIFIAILRM------RSAEAQRK 234
Cdd:cd15096 157 LTEVGTAAQTFFTSFFLFS---YLIPLTLICVLYMLMLRRLRRQkspggrRSAESQRG 211
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
23-145 2.80e-03

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 38.77  E-value: 2.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd15322   1 LTLIILVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALD 80
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMT--STTCILIVTW 145
Cdd:cd15322  81 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTprRIKCIIFIVW 125
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
28-152 3.15e-03

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 38.72  E-value: 3.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  28 IFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVAFGA 107
Cdd:cd15352   6 VFLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLETIMIAVLNSGYLVISDQFIQHMDNVFDSM 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 58801444 108 IESLILAS------MAYDRHAAVCKPLHYTTIMTS----TTCILIVTWCYTCGIL 152
Cdd:cd15352  86 ICISLVASicnllaIAVDRYVTIFYALRYHSIMTVrkalVLIAVIWVVCIVCGIV 140
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
25-137 3.52e-03

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 38.61  E-value: 3.52e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPkviegfLTGSKTISLN----GCAAQMF 100
Cdd:cd15205   3 FVITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIP------FTLLQNISSNwlggAFMCKMV 76
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 58801444 101 FFVAFGAIESLILA--SMAYDRHAAVCKPLHYTTIMTST 137
Cdd:cd15205  77 PFVQSTAVVTSILTmtCIAVERHQGIVHPLKMKWQYTNR 115
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
27-151 3.77e-03

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 38.37  E-value: 3.77e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  27 IIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSK-TISLNGCAAQMFFFVAF 105
Cdd:cd15304   5 LLTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRwPLPSKLCAVWIYLDVLF 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 58801444 106 GAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCIL--IVTWCYTCGI 151
Cdd:cd15304  85 STASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLkiIAVWTISVGI 132
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
27-145 4.33e-03

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 38.09  E-value: 4.33e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  27 IIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVAFG 106
Cdd:cd15059   5 SIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLALDVLFC 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 58801444 107 AIESLILASMAYDRHAAVCKPLHYTTIMTST--TCILIVTW 145
Cdd:cd15059  85 TASIVNLCAISLDRYWSVTQAVEYNLKRTPRraKAMIAAVW 125
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
28-158 4.94e-03

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 38.00  E-value: 4.94e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  28 IFTLIYLIALFGNLGMIILILLDSRLH--TPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTI-SLNGCAAQMFFFVA 104
Cdd:cd14981   6 PPALMFVFGVLGNLLALIVLARSSKSHkwSVFYRLVAGLAITDLLGILLTSPVVLAVYASNFEWDgGQPLCDYFGFMMSF 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 58801444 105 FGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCYTCGILQSSVHV 158
Cdd:cd14981  86 FGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIASLPL 139
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
27-299 5.77e-03

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 37.79  E-value: 5.77e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  27 IIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVyASAITPKVI------EGFLTGSKtislnGCAAQMF 100
Cdd:cd15000   4 SMFLPVVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLL-TLLVCPWMFlvhdffQNYVLGSV-----GCKLEGF 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 101 FFVAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWcyTCGILQSSvhvALAFSLSFCHSNVINHffcdip 180
Cdd:cd15000  78 LEGSLLLASVLALCAVSYDRLTAIVLPSEARLTKRGAKIVIVITW--IVGLLLAL---PLAIYRSYRERQWKNF------ 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 181 plLDISCS-DTHTNEITLLVLATLDLVFTLLVILNTYLLIFI-------AILRM---RSAEAQRKAFSTCASHLIT---V 246
Cdd:cd15000 147 --LETYCAeNTQVLPIYWHVIITVLVWLPLGIMLICYSAIFWkldkyerRVLRRehpSVVRYKKKAAKTLFIVLITfvvC 224
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 58801444 247 SIFFGSLIFMY--------LQPSSNHSMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNAF 299
Cdd:cd15000 225 RIPFTALIFYRyklvpndnTQNSVSGSFHILWFASKYLMFLNAAVNPLIYGFTNENFRKAF 285
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
31-145 5.78e-03

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 37.83  E-value: 5.78e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  31 LIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLN-GCAAQMFFFVAFGAIE 109
Cdd:cd15212   9 AIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRPGWLFGDrLCLANGFFNACFGIVS 88
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 58801444 110 SLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTW 145
Cdd:cd15212  89 TLTMTLISFDRYYAIVRQPQGKIGRRRALQLLAAAW 124
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
40-142 6.52e-03

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 37.45  E-value: 6.52e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  40 NLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIegfLTGSKTISLNgcAAQMF-----FFVAFGAiESLILA 114
Cdd:cd15102  18 NLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGAAYLANIL---LSGARTLRLS--PAQWFlregsMFVALSA-SVFSLL 91
                        90       100
                ....*....|....*....|....*...
gi 58801444 115 SMAYDRHAAVCKPLHYTTIMTSTTCILI 142
Cdd:cd15102  92 AIAIERHLTMAKMKPYGASKTSRVLLLI 119
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
27-299 6.62e-03

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 37.58  E-value: 6.62e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  27 IIFTLIylIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMfFFVAFG 106
Cdd:cd15401   7 LIFTIV--VDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISG-FLMGLS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 107 AIESLI-LASMAYDRHAAVCKPLHYTTI--MTSTTCILIVTWCYTCGILQSSVHVAlafSLSFchsnvinhffcdIPPLL 183
Cdd:cd15401  84 VIGSVFnITAIAINRYCYICHSLRYDKLynMKKTCCYVCLTWVLTLAAIVPNFFVG---SLQY------------DPRIY 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 184 DISCSDTHTNEITLLVLaTLDLVFTLLVILNTYLLIFIAILRMR---SAEAQRKAFSTCASHLITVSIFF-------GSL 253
Cdd:cd15401 149 SCTFAQTVSSSYTITVV-VVHFIVPLSIVTFCYLRIWVLVIQVKhrvRQDSKQKLKANDIRNFLTMFVVFvlfavcwGPL 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 58801444 254 IFMYLQPSSNHSMDTDKIA------SVFYTMVIPMLNPVVYSLRNKEVKNAF 299
Cdd:cd15401 228 NFIGLAVAINPLKVAPKIPewlfvlSYFMAYFNSCLNAVIYGVLNQNFRKEY 279
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
23-299 6.88e-03

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 37.56  E-value: 6.88e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd15326   1 ILLGLVLGAFILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTSTTCILIVTwcytcGILQSSVHVALAFSLSFCHSNVINHFFCDIppl 182
Cdd:cd15326  81 VLCCTASILSLCAISIDRYIGVRHSLQYPTIVTRKRAILALL-----GVWVLSTVISIGPLLGWKEPAPPDDKVCEI--- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 183 ldiscsdthTNEITLLVLATL-DLVFTLLVILNTYLLIFIAILRMRSAEAQRKAFSTCASHLITVSIFFgsLIFMYLQPS 261
Cdd:cd15326 153 ---------TEEPFYALFSSLgSFYIPLIVILVMYCRVYIVALKFSREKKAAKTLGIVVGMFILCWLPF--FIALPLGSL 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 58801444 262 SNHSMDTDKIASVFYTM--VIPMLNPVVYSLRNKEVKNAF 299
Cdd:cd15326 222 FSHLKPPETLFKIIFWLgyFNSCLNPIIYPCSSKEFKRAF 261
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
27-299 6.89e-03

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 37.33  E-value: 6.89e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  27 IIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSK-TISLNGCAAQMFFFVAF 105
Cdd:cd15053   5 LFLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVNGGKwYLGPILCDIYIAMDVMC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 106 GAIESLILASMAYDRHAAVCKPLHYTTIMTS--TTCILIVTWcytcgilqsSVHVALAFSLSFCHSNVinhffcdiPPLL 183
Cdd:cd15053  85 STASIFNLCAISIDRYIAVTQPIKYARQKNSkrVLLTIAIVW---------VVSAAIACPLLFGLNNV--------PYRD 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 184 DISCSDTHTNEITLLVLATLDLVFTLLVILntYLLIFIAILRMRSAEAQRK----AFSTCASHLITVSIFFGslIFMYLQ 259
Cdd:cd15053 148 PEECRFYNPDFIIYSSISSFYIPCIVMLLL--YYRIFRALRREKKATKTLAivlgVFLFCWLPFFTLNILNA--ICPKLQ 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 58801444 260 PSSNHSMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNAF 299
Cdd:cd15053 224 NQSCHVGPALFSLTTWLGYVNSFLNPIIYTIFNIEFRKAF 263
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
23-145 7.84e-03

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 37.47  E-value: 7.84e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  23 IPLFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFF 102
Cdd:cd15062   1 IVVGVALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVD 80
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 58801444 103 VAFGAIESLILASMAYDRHAAVCKPLHYTTIMTS--TTCILIVTW 145
Cdd:cd15062  81 VLCCTASIMSLCVISVDRYIGVRYPLNYPTIVTArrATVALLIVW 125
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
25-145 7.87e-03

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 37.53  E-value: 7.87e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  25 LFIIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITPKVIEGFLTGSKTISLNGCAAQMFFFVA 104
Cdd:cd15316   3 LYIVLGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGESFCTFHTCCDVS 82
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 58801444 105 FGAIESLILASMAYDRHAAVCKPLHYTTIMT---STTCIlIVTW 145
Cdd:cd15316  83 FCYASLFHLCFISVDRYIAVTDPLVYPTKFTvsvSGICI-SVSW 125
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
27-299 8.90e-03

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 37.13  E-value: 8.90e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444  27 IIFTLIYLIALFGNLGMIILILLDSRLHTPMYFFLCNLSVVDCVYASAITpkvIEGFLTGSKTISLNG---CAAQMFFFV 103
Cdd:cd16004   5 IAYSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNT---AFNFVYASHNDWYFGlefCRFQNFFPI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 104 A--FGAIESliLASMAYDRHAAVCKPLHYTTIMTSTTCILIVTWCytcgilqssvhVALAFSLSFCHSNVINHFF----C 177
Cdd:cd16004  82 TamFVSIYS--MTAIAADRYMAIIHPFKPRLSAGSTKVVIAGIWL-----------VALALAFPQCFYSTVTMDQgrtkC 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 178 DIPPLLDISCSDTHTNEITLLVLATLdlvFTLLVILNTYLLIFIAILR------------MRSAEAQRKAFSTCASHLIT 245
Cdd:cd16004 149 IVAWPGDSGGKHQLTYHLAVIVLIYL---LPLAVMFVTYSIIGITLWRsavpghqahgayHRQLQAKKKFVKTMVVVVVT 225
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801444 246 VSIFFGSLIFMYLQPSSN------HSMDTDKIASVFYTMVIPMLNPVVYSLRNKEVKNAF 299
Cdd:cd16004 226 FAICWLPYHLYFILGSFNediycqKYIQQVYLAIFWLAMSSTMYNPIIYCCLNQRFRSGF 285
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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