NCBI Conserved Domain Search

Conserved domains on [gi|58801290|ref|NP_001011751|]

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olfactory receptor family 14 subfamily A member 257 [Mus musculus]

Protein Classification

olfactory receptor family 14 protein( domain architecture ID 11607040)

olfactory receptor family 14 protein is an odorant receptor belonging to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

24-292

9.38e-134

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 381.03 E-value: 9.38e-134

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  24 VCGLFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMT 103
Cdd:cd15227   2 LHFVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 104 SFASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLL 183
Cdd:cd15227  82 FFAASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 184 RISCSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSV 263
Cdd:cd15227 162 KLSCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSD 241

                       250       260
                ....*....|....*....|....*....
gi 58801290 264 VPSISDRLFSVLHTVLPPALNPVIYSLRN 292
Cdd:cd15227 242 SPSLLDLLLSVFYSVVPPTLNPIIYSLRN 270

Name

Accession

Description

Interval

E-value

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

24-292

9.38e-134

Pssm-ID: 320355 Cd Length: 270 Bit Score: 381.03 E-value: 9.38e-134

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  24 VCGLFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMT 103
Cdd:cd15227   2 LHFVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 104 SFASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLL 183
Cdd:cd15227  82 FFAASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 184 RISCSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSV 263
Cdd:cd15227 162 KLSCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSD 241

                       250       260
                ....*....|....*....|....*....
gi 58801290 264 VPSISDRLFSVLHTVLPPALNPVIYSLRN 292
Cdd:cd15227 242 SPSLLDLLLSVFYSVVPPTLNPIIYSLRN 270

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

29-302

2.80e-31

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 118.76 E-value: 2.80e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290    29 FLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFASG 108
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290   109 DVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRISCS 188
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290   189 DILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYL--KPPSVVPS 266
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMvhRFGHNVPP 240

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 58801290   267 ISDRLFSVLHTVLPPALNPVIYSLRNSDVKRALKRL 302
Cdd:pfam13853 241 LLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRM 276

Name

Accession

Description

Interval

E-value

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

24-292

9.38e-134

Pssm-ID: 320355 Cd Length: 270 Bit Score: 381.03 E-value: 9.38e-134

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  24 VCGLFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMT 103
Cdd:cd15227   2 LHFVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 104 SFASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLL 183
Cdd:cd15227  82 FFAASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 184 RISCSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSV 263
Cdd:cd15227 162 KLSCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSD 241

                       250       260
                ....*....|....*....|....*....
gi 58801290 264 VPSISDRLFSVLHTVLPPALNPVIYSLRN 292
Cdd:cd15227 242 SPSLLDLLLSVFYSVVPPTLNPIIYSLRN 270

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

24-292

1.46e-103

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 304.41 E-value: 1.46e-103

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  24 VCGLFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMT 103
Cdd:cd13954   2 LLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 104 SFASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLL 183
Cdd:cd13954  82 SLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 184 RISCSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSV 263
Cdd:cd13954 162 KLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSS 241

                       250       260
                ....*....|....*....|....*....
gi 58801290 264 VPSISDRLFSVLHTVLPPALNPVIYSLRN 292
Cdd:cd13954 242 YSSDLDKVVSVFYTVVTPMLNPIIYSLRN 270

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

27-299

5.14e-96

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 285.50 E-value: 5.14e-96

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFA 106
Cdd:cd15225   5 VVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFLG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 107 SGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRIS 186
Cdd:cd15225  85 GTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVLKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 187 CSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVPS 266
Cdd:cd15225 165 CADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSSYSP 244

                       250       260       270
                ....*....|....*....|....*....|...
gi 58801290 267 ISDRLFSVLHTVLPPALNPVIYSLRNSDVKRAL 299
Cdd:cd15225 245 ETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

27-299

7.66e-89

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 267.59 E-value: 7.66e-89

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFA 106
Cdd:cd15231   5 LIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVSFV 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 107 SGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRIS 186
Cdd:cd15231  85 GTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLKLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 187 CSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVPS 266
Cdd:cd15231 165 CSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGYSL 244

                       250       260       270
                ....*....|....*....|....*....|...
gi 58801290 267 ISDRLFSVLHTVLPPALNPVIYSLRNSDVKRAL 299
Cdd:cd15231 245 DKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

22-299

1.19e-88

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 266.78 E-value: 1.19e-88

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  22 QTVCGLFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFL 101
Cdd:cd15235   1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 102 MTSFASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPS 181
Cdd:cd15235  81 FIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQP 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 182 LLRISCSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPP 261
Cdd:cd15235 161 LLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPS 240

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 58801290 262 SVVPSISDRLFSVLHTVLPPALNPVIYSLRNSDVKRAL 299
Cdd:cd15235 241 SSYSADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

10-303

1.58e-88

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 267.31 E-value: 1.58e-88

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  10 FILMGFSAAPELQTVCGLFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNS 89
Cdd:cd15943   2 FILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKT 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  90 ISILGCALQVFLMTSFASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGS 169
Cdd:cd15943  82 ISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCGS 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 170 IVIPQFFCDVPSLLRISCSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVF 249
Cdd:cd15943 162 NVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTIF 241

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 58801290 250 IVTACFVYLKPPSVVPSISDRLFSVLHTVLPPALNPVIYSLRNSDVKRALKRLQ 303
Cdd:cd15943 242 YGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

27-299

3.74e-86

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 260.61 E-value: 3.74e-86

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFA 106
Cdd:cd15229   5 LVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFA 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 107 SGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRIS 186
Cdd:cd15229  85 GTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLPLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 187 CSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVPS 266
Cdd:cd15229 165 CSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSASSS 244

                       250       260       270
                ....*....|....*....|....*....|...
gi 58801290 267 ISDRLFSVLHTVLPPALNPVIYSLRNSDVKRAL 299
Cdd:cd15229 245 VLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

10-302

8.86e-86

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 260.28 E-value: 8.86e-86

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  10 FILMGFSAAPELQTVCGLFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNS 89
Cdd:cd15410   1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  90 ISILGCALQVFLMTSFASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGS 169
Cdd:cd15410  81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 170 IVIPQFFCDVPSLLRISCSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVF 249
Cdd:cd15410 161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 58801290 250 IVTACFVYLKPPSVVPSISDRLFSVLHTVLPPALNPVIYSLRNSDVKRALKRL 302
Cdd:cd15410 241 HGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKL 293

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

27-292

8.89e-86

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 259.36 E-value: 8.89e-86

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFA 106
Cdd:cd15230   5 VLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 107 SGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRIS 186
Cdd:cd15230  85 TTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLLKLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 187 CSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVPS 266
Cdd:cd15230 165 CSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSSYSL 244

                       250       260
                ....*....|....*....|....*.
gi 58801290 267 ISDRLFSVLHTVLPPALNPVIYSLRN 292
Cdd:cd15230 245 DQDKVVSVFYTVVIPMLNPLIYSLRN 270

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

29-292

1.05e-85

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 259.08 E-value: 1.05e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  29 FLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFASG 108
Cdd:cd15918   7 FLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFGDL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 109 DVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRISCS 188
Cdd:cd15918  87 DNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLKLSCS 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 189 DIL---VVIYTslgMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVP 265
Cdd:cd15918 167 DTHlneLVILV---LGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSHS 243

                       250       260
                ....*....|....*....|....*..
gi 58801290 266 SISDRLFSVLHTVLPPALNPVIYSLRN 292
Cdd:cd15918 244 ASKDSVAAVMYTVVTPMLNPFIYSLRN 270

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

30-299

1.50e-83

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 254.01 E-value: 1.50e-83

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  30 LVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFASGD 109
Cdd:cd15421   8 LLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLTLGGAE 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 110 VFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRISCSD 189
Cdd:cd15421  88 CLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLKLSCAD 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 190 ILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVPSISD 269
Cdd:cd15421 168 TSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSYHSPEQD 247

                       250       260       270
                ....*....|....*....|....*....|
gi 58801290 270 RLFSVLHTVLPPALNPVIYSLRNSDVKRAL 299
Cdd:cd15421 248 KVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

27-301

2.19e-82

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 251.07 E-value: 2.19e-82

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFA 106
Cdd:cd15419   5 LLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLFG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 107 SGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRIS 186
Cdd:cd15419  85 TTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLLKLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 187 CSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVPS 266
Cdd:cd15419 165 CSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGAVSSP 244

                       250       260       270
                ....*....|....*....|....*....|....*
gi 58801290 267 ISDRLFSVLHTVLPPALNPVIYSLRNSDVKRALKR 301
Cdd:cd15419 245 EQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

27-292

5.10e-82

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 249.71 E-value: 5.10e-82

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFA 106
Cdd:cd15912   5 LLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFFLG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 107 SGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRIS 186
Cdd:cd15912  85 TTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLLKLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 187 CSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVPS 266
Cdd:cd15912 165 CSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQSSSL 244

                       250       260
                ....*....|....*....|....*.
gi 58801290 267 ISDRLFSVLHTVLPPALNPVIYSLRN 292
Cdd:cd15912 245 DLNKVVALLNTVVTPLLNPFIYTLRN 270

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

10-296

1.72e-81

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 249.16 E-value: 1.72e-81

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  10 FILMGFSAAPELQTVCGLFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNS 89
Cdd:cd15408   1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  90 ISILGCALQVFLMTSFASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGS 169
Cdd:cd15408  81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 170 IVIPQFFCDVPSLLRISCSDI---LVVIYTSLGMGVclgMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVF 246
Cdd:cd15408 161 NVINHFFCDGPPLLALSCSDTslnEMLLFAFVGFNV---LTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAV 237

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 58801290 247 SVFIVTACFVYLKPPSVVPSISDRLFSVLHTVLPPALNPVIYSLRNSDVK 296
Cdd:cd15408 238 TLFYGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

29-301

3.35e-79

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 242.93 E-value: 3.35e-79

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  29 FLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFASG 108
Cdd:cd15417   7 FLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGMGLT 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 109 DVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRISCS 188
Cdd:cd15417  87 ECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLLSLSCS 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 189 DILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVPSIS 268
Cdd:cd15417 167 DTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSSHSQDQ 246

                       250       260       270
                ....*....|....*....|....*....|...
gi 58801290 269 DRLFSVLHTVLPPALNPVIYSLRNSDVKRALKR 301
Cdd:cd15417 247 DKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

27-292

1.60e-77

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 238.15 E-value: 1.60e-77

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFA 106
Cdd:cd15911   5 LLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSLA 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 107 SGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRIS 186
Cdd:cd15911  85 ATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLKLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 187 CSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVPS 266
Cdd:cd15911 165 CSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTNTSR 244

                       250       260
                ....*....|....*....|....*.
gi 58801290 267 ISDRLFSVLHTVLPPALNPVIYSLRN 292
Cdd:cd15911 245 DLNKVFSLFYTVLTPLVNPLIYSLRN 270

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

27-292

5.57e-77

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 236.79 E-value: 5.57e-77

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFA 106
Cdd:cd15237   5 ILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLALG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 107 SGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRIS 186
Cdd:cd15237  85 VTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVLKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 187 CSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVPS 266
Cdd:cd15237 165 CADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHSTHSP 244

                       250       260
                ....*....|....*....|....*.
gi 58801290 267 ISDRLFSVLHTVLPPALNPVIYSLRN 292
Cdd:cd15237 245 DQDKMISVFYTIVTPMLNPLIYSLRN 270

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

27-292

7.81e-77

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 236.39 E-value: 7.81e-77

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFA 106
Cdd:cd15232   5 WLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWSL 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 107 SGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRIS 186
Cdd:cd15232  85 GSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLLLLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 187 CSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVPS 266
Cdd:cd15232 165 CSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSSYSP 244

                       250       260
                ....*....|....*....|....*.
gi 58801290 267 ISDRLFSVLHTVLPPALNPVIYSLRN 292
Cdd:cd15232 245 EKDKVVAVLYSVVTPTLNPLIYSLRN 270

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

27-301

9.17e-74

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 229.18 E-value: 9.17e-74

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFA 106
Cdd:cd15416   5 VLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATFG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 107 SGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRIS 186
Cdd:cd15416  85 TVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLKLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 187 CSDI-LVVIYTSLGMGVCLgMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVP 265
Cdd:cd15416 165 CSDIrLAKILPSISSGIII-LVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSYS 243

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 58801290 266 SISDRLFSVLHTVLPPALNPVIYSLRNSDVKRALKR 301
Cdd:cd15416 244 MDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

27-301

4.83e-72

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 224.50 E-value: 4.83e-72

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFA 106
Cdd:cd15411   5 VLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIALA 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 107 SGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRIS 186
Cdd:cd15411  85 TTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLKLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 187 CSDILV---VIYTSLGMGVclgMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSV 263
Cdd:cd15411 165 CSDTHVnemLIFILAGLTL---VGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSS 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 58801290 264 VPSISDRLFSVLHTVLPPALNPVIYSLRNSDVKRALKR 301
Cdd:cd15411 242 YSLGQDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

28-299

2.54e-71

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 222.45 E-value: 2.54e-71

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  28 FFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFAS 107
Cdd:cd15234   6 LFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLFGG 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 108 GDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRISC 187
Cdd:cd15234  86 LDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLKLAC 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 188 SDIL---VVIYTslgMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVV 264
Cdd:cd15234 166 SDTLinnILIYL---ATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVTH 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 58801290 265 PSISDRLFSVLHTVLPPALNPVIYSLRNSDVKRAL 299
Cdd:cd15234 243 SSRKTAVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

10-301

2.89e-71

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 223.08 E-value: 2.89e-71

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  10 FILMGFSAAPELQTVCGLFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNS 89
Cdd:cd15945   1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  90 ISILGCALQVFLMTSFASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGS 169
Cdd:cd15945  81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 170 IVIPQFFCDVPSLLRISCSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVF 249
Cdd:cd15945 161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 58801290 250 IVTACFVYLKPPSVVPSISDRLFSVLHTVLPPALNPVIYSLRNSDVKRALKR 301
Cdd:cd15945 241 YGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

14-302

4.59e-71

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 222.63 E-value: 4.59e-71

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  14 GFSAAPELQTVCGLFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISIL 93
Cdd:cd15406   1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  94 GCALQVFLMTSFASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIP 173
Cdd:cd15406  81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 174 QFFCDVPSLLRISCSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTA 253
Cdd:cd15406 161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 58801290 254 CFVYLKPPSVVPSISDRLFSVLHTVLPPALNPVIYSLRNSDVKRALKRL 302
Cdd:cd15406 241 IFMYLKPSSSSSMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKV 289

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

29-301

5.27e-71

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 221.81 E-value: 5.27e-71

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  29 FLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFASG 108
Cdd:cd15413   7 FLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTFIIS 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 109 DVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRISCS 188
Cdd:cd15413  87 ELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLALSCS 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 189 DILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVPSIS 268
Cdd:cd15413 167 DTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSSHSLDT 246

                       250       260       270
                ....*....|....*....|....*....|...
gi 58801290 269 DRLFSVLHTVLPPALNPVIYSLRNSDVKRALKR 301
Cdd:cd15413 247 DKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

27-301

2.49e-70

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 220.36 E-value: 2.49e-70

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFA 106
Cdd:cd15409   5 LVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSA 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 107 SGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRIS 186
Cdd:cd15409  85 TTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLLKIS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 187 CSD----ILVVIYTSLGMGVclgmSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPS 262
Cdd:cd15409 165 CTDpsinELVLFIFSGSIQV----FTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSS 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 58801290 263 VVPSISDRLFSVLHTVLPPALNPVIYSLRNSDVKRALKR 301
Cdd:cd15409 241 LYALDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

26-299

9.29e-70

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 218.81 E-value: 9.29e-70

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  26 GLF--FLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMT 103
Cdd:cd15429   2 GLFvlFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 104 SFASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLL 183
Cdd:cd15429  82 ALGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 184 RISCSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSV 263
Cdd:cd15429 162 RLACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSG 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 58801290 264 VPSISDRLFSVLHTVLPPALNPVIYSLRNSDVKRAL 299
Cdd:cd15429 242 SSALQEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

25-299

1.57e-69

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 217.97 E-value: 1.57e-69

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  25 CGLFFLVmYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTS 104
Cdd:cd15420   4 FGLFSLL-YIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 105 FASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLR 184
Cdd:cd15420  83 LAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 185 ISCSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVV 264
Cdd:cd15420 163 LACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSN 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 58801290 265 PSISDRLFSVLHTVLPPALNPVIYSLRNSDVKRAL 299
Cdd:cd15420 243 SAEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

27-292

1.73e-69

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 217.54 E-value: 1.73e-69

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFA 106
Cdd:cd15224   5 LLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSLA 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 107 SGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRIS 186
Cdd:cd15224  85 CTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLNLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 187 CSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVPS 266
Cdd:cd15224 165 CTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAISSF 244

                       250       260
                ....*....|....*....|....*.
gi 58801290 267 ISDRLFSVLHTVLPPALNPVIYSLRN 292
Cdd:cd15224 245 DSNKLVSVLYTVVTPLLNPIIYCLRN 270

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

27-292

2.05e-68

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 214.93 E-value: 2.05e-68

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFA 106
Cdd:cd15430   5 VLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAMG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 107 SGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRIS 186
Cdd:cd15430  85 STECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVLKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 187 CSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVPS 266
Cdd:cd15430 165 CVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSKNAQ 244

                       250       260
                ....*....|....*....|....*.
gi 58801290 267 ISDRLFSVLHTVLPPALNPVIYSLRN 292
Cdd:cd15430 245 ISDKLITLFYGVVTPMLNPIIYSLRN 270

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

29-299

3.60e-67

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 211.90 E-value: 3.60e-67

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  29 FLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFASG 108
Cdd:cd15424   7 ILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALSLGST 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 109 DVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRISCS 188
Cdd:cd15424  87 ECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 189 DILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVPSIS 268
Cdd:cd15424 167 DTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGSTPDR 246

                       250       260       270
                ....*....|....*....|....*....|.
gi 58801290 269 DRLFSVLHTVLPPALNPVIYSLRNSDVKRAL 299
Cdd:cd15424 247 DKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

27-301

9.32e-67

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 211.12 E-value: 9.32e-67

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFA 106
Cdd:cd15407   5 IIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVFA 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 107 SGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRIS 186
Cdd:cd15407  85 TVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLALS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 187 CSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVPS 266
Cdd:cd15407 165 CSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSHSM 244

                       250       260       270
                ....*....|....*....|....*....|....*
gi 58801290 267 ISDRLFSVLHTVLPPALNPVIYSLRNSDVKRALKR 301
Cdd:cd15407 245 DTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

27-292

1.23e-66

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 210.63 E-value: 1.23e-66

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFA 106
Cdd:cd15915   5 VLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFLG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 107 SGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRIS 186
Cdd:cd15915  85 SSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 187 CSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTK-GQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVP 265
Cdd:cd15915 165 CGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLLLKVRSKeGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSGDS 244

                       250       260
                ....*....|....*....|....*..
gi 58801290 266 SISDRLFSVLHTVLPPALNPVIYSLRN 292
Cdd:cd15915 245 LEQDRIVALLYTVVTPVLNPLIYTLRN 271

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

29-301

2.40e-66

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 209.95 E-value: 2.40e-66

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  29 FLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFASG 108
Cdd:cd15412   7 FLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIALVIT 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 109 DVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRISCS 188
Cdd:cd15412  87 EYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLIKLSCS 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 189 DILVVIYTSLGM-GVCLGMSCFIcVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVPSI 267
Cdd:cd15412 167 DTYVKETAMFIVaGFNLSSSLLI-ILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSEESVE 245

                       250       260       270
                ....*....|....*....|....*....|....
gi 58801290 268 SDRLFSVLHTVLPPALNPVIYSLRNSDVKRALKR 301
Cdd:cd15412 246 QSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

27-301

2.85e-66

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 209.98 E-value: 2.85e-66

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFA 106
Cdd:cd15414   5 LLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLFV 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 107 SGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRIS 186
Cdd:cd15414  85 AAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLLSLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 187 CSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVPS 266
Cdd:cd15414 165 CADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSSSSL 244

                       250       260       270
                ....*....|....*....|....*....|....*
gi 58801290 267 ISDRLFSVLHTVLPPALNPVIYSLRNSDVKRALKR 301
Cdd:cd15414 245 DLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRR 279

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

27-301

4.39e-66

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 209.19 E-value: 4.39e-66

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFA 106
Cdd:cd15415   5 MLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFV 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 107 SGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRIS 186
Cdd:cd15415  85 TTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 187 CSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVPS 266
Cdd:cd15415 165 CSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQYSL 244

                       250       260       270
                ....*....|....*....|....*....|....*
gi 58801290 267 ISDRLFSVLHTVLPPALNPVIYSLRNSDVKRALKR 301
Cdd:cd15415 245 EQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

10-302

5.25e-66

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 209.64 E-value: 5.25e-66

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  10 FILMGFSAAPELQTVCGLFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNS 89
Cdd:cd15944   1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  90 ISILGCALQVFLMTSFASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGS 169
Cdd:cd15944  81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 170 IVIPQFFCDVPSLLRISCSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVF 249
Cdd:cd15944 161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 58801290 250 IVTACFVYLKPPSVVPSISDRLFSVLHTVLPPALNPVIYSLRNSDVKRALKRL 302
Cdd:cd15944 241 YGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKL 293

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

28-299

2.54e-65

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 207.23 E-value: 2.54e-65

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  28 FFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFAS 107
Cdd:cd15434   6 VVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALGLGG 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 108 GDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRISC 187
Cdd:cd15434  86 TECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALIKLAC 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 188 SDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVPSI 267
Cdd:cd15434 166 VDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNSVSQD 245

                       250       260       270
                ....*....|....*....|....*....|..
gi 58801290 268 SDRLFSVLHTVLPPALNPVIYSLRNSDVKRAL 299
Cdd:cd15434 246 QGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

24-299

3.86e-65

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 206.93 E-value: 3.86e-65

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  24 VCGLFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMT 103
Cdd:cd15236   2 VFFALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 104 SFASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLL 183
Cdd:cd15236  82 FFGCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 184 RISCSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSV 263
Cdd:cd15236 162 KLSCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSN 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 58801290 264 VPSISDRLFSVLHTVLPPALNPVIYSLRNSDVKRAL 299
Cdd:cd15236 242 NSSDKDIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

24-292

8.30e-65

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 205.52 E-value: 8.30e-65

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  24 VCGLFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMT 103
Cdd:cd15939   2 ICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 104 SFASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLL 183
Cdd:cd15939  82 FFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 184 RISCSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTvLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSV 263
Cdd:cd15939 162 KLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYS-LRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTT 240

                       250       260
                ....*....|....*....|....*....
gi 58801290 264 VPsiSDRLFSVLHTVLPPALNPVIYSLRN 292
Cdd:cd15939 241 FP--IDKVVAVFYTIITPMLNPLIYTLRN 267

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

27-292

1.53e-63

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 202.45 E-value: 1.53e-63

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFA 106
Cdd:cd15431   5 VLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFLG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 107 SGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALyTAGTFSMPFCGSIVIPQFFCDVPSLLRIS 186
Cdd:cd15431  85 ITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVI-PVLTMPLHFCGPNVINHFFCEVQALLKLA 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 187 CSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVPS 266
Cdd:cd15431 164 CSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSKSSS 243

                       250       260
                ....*....|....*....|....*.
gi 58801290 267 ISDRLFSVLHTVLPPALNPVIYSLRN 292
Cdd:cd15431 244 DQDKIISVFYGVVTPMLNPLIYSLRN 269

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

27-292

2.59e-63

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 201.70 E-value: 2.59e-63

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFA 106
Cdd:cd15947   5 VVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLWLG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 107 SGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRIS 186
Cdd:cd15947  85 STECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 187 CSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVPS 266
Cdd:cd15947 165 CVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSSYSQ 244

                       250       260
                ....*....|....*....|....*.
gi 58801290 267 ISDRLFSVLHTVLPPALNPVIYSLRN 292
Cdd:cd15947 245 DQGKFISLFYTVVTPTLNPLIYTLRN 270

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

29-299

2.97e-62

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 199.63 E-value: 2.97e-62

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  29 FLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFASG 108
Cdd:cd15432   7 FLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLGLGST 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 109 DVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRISCS 188
Cdd:cd15432  87 ECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLKLSCV 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 189 DILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVPSIS 268
Cdd:cd15432 167 DTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSNSSHDR 246

                       250       260       270
                ....*....|....*....|....*....|.
gi 58801290 269 DRLFSVLHTVLPPALNPVIYSLRNSDVKRAL 299
Cdd:cd15432 247 GKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

27-292

1.45e-61

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 197.43 E-value: 1.45e-61

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFA 106
Cdd:cd15226   5 VFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHFFG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 107 SGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRIS 186
Cdd:cd15226  85 GSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVIKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 187 CSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKiPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVPs 266
Cdd:cd15226 165 CTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRK-HSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTFP- 242

                       250       260
                ....*....|....*....|....*.
gi 58801290 267 iSDRLFSVLHTVLPPALNPVIYSLRN 292
Cdd:cd15226 243 -VDKFLAVFYTVITPLLNPIIYTLRN 267

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

27-299

3.47e-61

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 196.52 E-value: 3.47e-61

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHN-NSISILGCALQVFLMTSF 105
Cdd:cd15916   5 LIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGgKVISFGGCVAQLYFFHFL 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 106 ASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRI 185
Cdd:cd15916  85 GSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLLKL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 186 SCSDILV---VIYTSLGMgvcLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPS 262
Cdd:cd15916 165 ACADTTInelVIFASIGV---VALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGS 241

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 58801290 263 VVPsiSDRLFSVLHTVLPPALNPVIYSLRNSDVKRAL 299
Cdd:cd15916 242 KEA--LDGVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

28-292

6.11e-61

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 195.78 E-value: 6.11e-61

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  28 FFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFAS 107
Cdd:cd15946   6 VFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLALGI 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 108 GDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRISC 187
Cdd:cd15946  86 TECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLKLAC 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 188 SDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVPSI 267
Cdd:cd15946 166 ADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSNYSPE 245

                       250       260
                ....*....|....*....|....*
gi 58801290 268 SDRLFSVLHTVLPPALNPVIYSLRN 292
Cdd:cd15946 246 RDKKISLFYNVFTALLNPVIYSLRN 270

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

23-292

7.74e-61

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 195.67 E-value: 7.74e-61

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  23 TVCGLFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLM 102
Cdd:cd15914   1 LLLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 103 TSFASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSL 182
Cdd:cd15914  81 HSLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 183 LRISCSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPS 262
Cdd:cd15914 161 LSLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSK 240

                       250       260       270
                ....*....|....*....|....*....|
gi 58801290 263 VVPSISDRLFSVLHTVLPPALNPVIYSLRN 292
Cdd:cd15914 241 SYSLDYDRAIAVVYAVLTPFFNPIIYSLRN 270

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

29-299

1.68e-60

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 195.01 E-value: 1.68e-60

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  29 FLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFASG 108
Cdd:cd15233   7 FLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHLLAGA 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 109 DVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRISCS 188
Cdd:cd15233  87 DCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQLSCS 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 189 DI----LVVIYTSLGMGVclgmSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVV 264
Cdd:cd15233 167 SThlneLLLFVFAFFMAL----APCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSVY 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 58801290 265 PSISDRLFSVLHTVLPPALNPVIYSLRNSDVKRAL 299
Cdd:cd15233 243 SSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

29-302

1.78e-60

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 195.00 E-value: 1.78e-60

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  29 FLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFASG 108
Cdd:cd15418   8 FLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSAGLAYS 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 109 DVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRISCS 188
Cdd:cd15418  88 ECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLVKLACD 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 189 DILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVPSIS 268
Cdd:cd15418 168 DTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPSSSHTPDR 247

                       250       260       270
                ....*....|....*....|....*....|....
gi 58801290 269 DRLFSVLHTVLPPALNPVIYSLRNSDVKRALKRL 302
Cdd:cd15418 248 DKVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

29-292

1.80e-60

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 194.58 E-value: 1.80e-60

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  29 FLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFASG 108
Cdd:cd15940   7 FLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFACT 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 109 DVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRISCS 188
Cdd:cd15940  87 EIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIKLACT 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 189 D---ILVVIYTSLGMgvcLGMSCFICVVISYFYIFSTVLKIpTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVP 265
Cdd:cd15940 167 DtylIDILIVSNSGL---ISLVCFVALLGSYIVILVSLRKR-STEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSFS 242

                       250       260
                ....*....|....*....|....*..
gi 58801290 266 siSDRLFSVLHTVLPPALNPVIYSLRN 292
Cdd:cd15940 243 --EDKVVSVFYTVVTPLLNPIIYTLRN 267

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

27-299

4.40e-59

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 191.22 E-value: 4.40e-59

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQT-PMYFFLKNLSLLDIFFISVPIPNFFINSITHN-NSISILGCALQVFLMTS 104
Cdd:cd15941   5 LLFLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSgRTISFEGCVVQLYAFHF 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 105 FASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLR 184
Cdd:cd15941  85 LASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPVLK 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 185 ISCSDILV---VIYTSLGMgvcLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPP 261
Cdd:cd15941 165 LACADTTInelVILANIGI---VAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPS 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 58801290 262 SvvPSISDRLFSVLHTVLPPALNPVIYSLRNSDVKRAL 299
Cdd:cd15941 242 S--SQAGAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

29-299

7.35e-59

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 190.72 E-value: 7.35e-59

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  29 FLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFASG 108
Cdd:cd15228   7 FLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFLGST 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 109 DVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRISCS 188
Cdd:cd15228  87 ECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 189 DILV---VIYTSLGMgvcLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKP-PSVV 264
Cdd:cd15228 167 DTSIaetVSFTNVGL---VPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPtPSPV 243

                       250       260       270
                ....*....|....*....|....*....|....*
gi 58801290 265 PSISDRLFSVLHTvlpPALNPVIYSLRNSDVKRAL 299
Cdd:cd15228 244 LVTPVQIFNNVVT---PMLNPLIYTLRNKEVKAAL 275

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

27-292

1.45e-58

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 189.47 E-value: 1.45e-58

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFA 106
Cdd:cd15936   5 LVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 107 SGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRIS 186
Cdd:cd15936  85 GAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 187 CSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFsTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVPs 266
Cdd:cd15936 165 CTDTFLLELLMVSNSGLVTLLIFFILLISYTVIL-VKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQTFP- 242

                       250       260
                ....*....|....*....|....*.
gi 58801290 267 iSDRLFSVLHTVLPPALNPVIYSLRN 292
Cdd:cd15936 243 -MDKAVSVLYTVITPMLNPMIYTLRN 267

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

27-299

2.83e-58

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 189.16 E-value: 2.83e-58

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFA 106
Cdd:cd15405   5 FLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFFV 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 107 SGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRIS 186
Cdd:cd15405  85 ISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 187 CSDILVV-IYTSLGMGVCLGMSCFIcVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVP 265
Cdd:cd15405 165 CTSTYVNeLVVFVVVGINIIVPSVT-IFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVGS 243

                       250       260       270
                ....*....|....*....|....*....|....
gi 58801290 266 SISDRLFSVLHTVLPPALNPVIYSLRNSDVKRAL 299
Cdd:cd15405 244 VNQGKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

29-292

3.94e-57

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 185.85 E-value: 3.94e-57

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  29 FLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFASG 108
Cdd:cd15938   7 FLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFVGAA 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 109 DVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRISCS 188
Cdd:cd15938  87 EMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIKLACT 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 189 DILVVIYTSLGMGVCLGMSCFICVVISYFYIfstVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVPsiS 268
Cdd:cd15938 167 DTCVTELLMVSNSGLISTVCFVVLVTSYTTI---LVTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTFP--V 241

                       250       260
                ....*....|....*....|....
gi 58801290 269 DRLFSVLHTVLPPALNPVIYSLRN 292
Cdd:cd15938 242 DKHVSVLYNVITPMLNPLIYTLRN 265

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

27-299

7.51e-57

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 185.38 E-value: 7.51e-57

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFA 106
Cdd:cd15428   5 ILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLSFG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 107 SGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRIS 186
Cdd:cd15428  85 ITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 187 CSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVPS 266
Cdd:cd15428 165 STDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSSTSK 244

                       250       260       270
                ....*....|....*....|....*....|...
gi 58801290 267 ISDRLFSVLHTVLPPALNPVIYSLRNSDVKRAL 299
Cdd:cd15428 245 EYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

27-299

2.52e-54

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 178.78 E-value: 2.52e-54

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFA 106
Cdd:cd15942   5 LFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFLG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 107 SGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRIS 186
Cdd:cd15942  85 CAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 187 CSDIL---VVIYTSLGMgvcLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSV 263
Cdd:cd15942 165 CADTAfneLVTFIDIGL---VAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQ 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 58801290 264 VPsiSDRLFSVLHTVLPPALNPVIYSLRNSDVKRAL 299
Cdd:cd15942 242 DP--LDGVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

27-292

1.80e-52

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 173.80 E-value: 1.80e-52

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKL-QTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSF 105
Cdd:cd15935   5 VLVLACYAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLHFL 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 106 ASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRI 185
Cdd:cd15935  85 GGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQVIKL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 186 SCSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTvLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSvvP 265
Cdd:cd15935 165 ACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTT-LRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFS--S 241

                       250       260
                ....*....|....*....|....*..
gi 58801290 266 SISDRLFSVLHTVLPPALNPVIYSLRN 292
Cdd:cd15935 242 SSVDKVASVFYTLITPALNPLIYTLRN 268

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

28-292

1.39e-51

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 171.73 E-value: 1.39e-51

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  28 FFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFAS 107
Cdd:cd15913   6 FFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFSLGT 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 108 GDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRISC 187
Cdd:cd15913  86 TECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLALSC 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 188 SDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVPSI 267
Cdd:cd15913 166 VPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSGNSTG 245

                       250       260
                ....*....|....*....|....*
gi 58801290 268 SDRLFSVLHTVLPPALNPVIYSLRN 292
Cdd:cd15913 246 MQKIVTLFYSVVTPLLNPLIYSLRN 270

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

27-292

1.57e-49

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 166.45 E-value: 1.57e-49

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFA 106
Cdd:cd15937   5 VLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHFLG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 107 SGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRIS 186
Cdd:cd15937  85 AAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVIKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 187 CSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTvLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVPs 266
Cdd:cd15937 165 CTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAK-LRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRSFP- 242

                       250       260
                ....*....|....*....|....*.
gi 58801290 267 iSDRLFSVLHTVLPPALNPVIYSLRN 292
Cdd:cd15937 243 -MDKVVAVFHTVIFPLLNPMIYTLRN 267

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

27-299

6.41e-47

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 159.96 E-value: 6.41e-47

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFA 106
Cdd:cd15433   5 VVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLALG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 107 SGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRIS 186
Cdd:cd15433  85 SAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 187 CSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSVVPS 266
Cdd:cd15433 165 CGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHRYSQ 244

                       250       260       270
                ....*....|....*....|....*....|...
gi 58801290 267 ISDRLFSVLHTVLPPALNPVIYSLRNSDVKRAL 299
Cdd:cd15433 245 AHGKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

29-299

2.27e-46

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 158.22 E-value: 2.27e-46

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  29 FLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFASG 108
Cdd:cd15223   7 FLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHFFTAM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 109 DVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRISCS 188
Cdd:cd15223  87 ESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVSLACG 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 189 DILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYL--KPPSVVPS 266
Cdd:cd15223 167 DTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLtyRFGKTIPP 246

                       250       260       270
                ....*....|....*....|....*....|...
gi 58801290 267 ISDRLFSVLHTVLPPALNPVIYSLRNSDVKRAL 299
Cdd:cd15223 247 DVHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

26-292

1.01e-36

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 133.18 E-value: 1.01e-36

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  26 GLFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSF 105
Cdd:cd15917   4 SIPFCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 106 ASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRI 185
Cdd:cd15917  84 TAMESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 186 SCSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYL--KPPSV 263
Cdd:cd15917 164 ACGDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLthRFGHH 243

                       250       260
                ....*....|....*....|....*....
gi 58801290 264 VPSISDRLFSVLHTVLPPALNPVIYSLRN 292
Cdd:cd15917 244 VPPHVHILLANLYLLLPPMLNPIVYGVRT 272

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

29-291

4.56e-36

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 131.35 E-value: 4.56e-36

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  29 FLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPN----FFINSithnNSISILGCALQVFLMTS 104
Cdd:cd15952   7 FCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKmlgiFWFNL----REISFGGCLAQMFFIHT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 105 FASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLR 184
Cdd:cd15952  83 FTGMESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 185 ISCSDILVVIYTSLGMGVCLGMScFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYL--KPPS 262
Cdd:cd15952 163 LACASIRINIIYGLFAISVLVLD-VILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLthRFGH 241

                       250       260
                ....*....|....*....|....*....
gi 58801290 263 VVPSISDRLFSVLHTVLPPALNPVIYSLR 291
Cdd:cd15952 242 NIPRYIHILLANLYVVLPPMLNPVIYGVR 270

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

29-291

3.85e-35

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 128.95 E-value: 3.85e-35

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  29 FLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFASG 108
Cdd:cd15221   7 FCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVT 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 109 DVFVLTAMSYDHYVAICCPLHYETIMSSGNC--VLMVGVSWAIGVLFGALYTAGtfSMPFCGSIVIPQFFCDVPSLLRIS 186
Cdd:cd15221  87 ESAILLAMAFDRYVAICYPLRYTTILTHSVIgkIGVAAVARSFCIVFPFVFLLK--RLPYCGHNVIPHTYCEHMGIARLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 187 CSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYL--KPPSVV 264
Cdd:cd15221 165 CADITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLthRFGRHI 244

                       250       260
                ....*....|....*....|....*..
gi 58801290 265 PSISDRLFSVLHTVLPPALNPVIYSLR 291
Cdd:cd15221 245 PRHVHILLANLYVLVPPMLNPIVYGVK 271

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

26-291

2.46e-34

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 126.76 E-value: 2.46e-34

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  26 GLFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSF 105
Cdd:cd15950   4 AIPFCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 106 ASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRI 185
Cdd:cd15950  84 TAVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 186 SCSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACF-VYLKP-PSV 263
Cdd:cd15950 164 ACADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLsIYTQRfGQG 243

                       250       260
                ....*....|....*....|....*...
gi 58801290 264 VPSISDRLFSVLHTVLPPALNPVIYSLR 291
Cdd:cd15950 244 VPPHTQVLLADLYLLVPPMLNPIIYGMR 271

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

29-292

1.92e-33

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 124.38 E-value: 1.92e-33

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  29 FLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFASG 108
Cdd:cd15951   7 FCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 109 DVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRISCS 188
Cdd:cd15951  87 ESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 189 DILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYL--KPPSVVPS 266
Cdd:cd15951 167 DTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLthRFGHNVPP 246

                       250       260
                ....*....|....*....|....*.
gi 58801290 267 ISDRLFSVLHTVLPPALNPVIYSLRN 292
Cdd:cd15951 247 HVHILIANVYLLVPPMLNPIIYGVRT 272

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

29-292

5.90e-32

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 120.45 E-value: 5.90e-32

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  29 FLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPN----FFINSithnNSISILGCALQVFLMTS 104
Cdd:cd15953   7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKalciFWFNL----KEITFSGCLTQMFFIHT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 105 FASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLR 184
Cdd:cd15953  83 LSIMESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 185 ISCSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLK---PP 261
Cdd:cd15953 163 LACGDTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLThrfGQ 242

                       250       260       270
                ....*....|....*....|....*....|.
gi 58801290 262 SVVPSISdRLFSVLHTVLPPALNPVIYSLRN 292
Cdd:cd15953 243 GIAPHIH-IILANLYLLVPPMLNPIIYGVKT 272

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

29-302

2.80e-31

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 118.76 E-value: 2.80e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290    29 FLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFASG 108
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290   109 DVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRISCS 188
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290   189 DILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYL--KPPSVVPS 266
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMvhRFGHNVPP 240

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 58801290   267 ISDRLFSVLHTVLPPALNPVIYSLRNSDVKRALKRL 302
Cdd:pfam13853 241 LLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRM 276

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

27-291

5.56e-29

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 112.59 E-value: 5.56e-29

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPN----FFINSithnNSISILGCALQVFLM 102
Cdd:cd15222   5 IPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTvlgiFWFNA----REISFDACLAQMFFI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 103 TSFASGDVFVLTAMSYDHYVAICCPLHYETIMSSGnCVLMVGVswAIGVLFGALYTAGTF---SMPFCGSIVIPQFFCDV 179
Cdd:cd15222  81 HTFSFMESSVLLAMAFDRFVAICNPLRYASILTNS-RIAKIGL--AIVLRSVLLLLPLPFllkRLPFCHSNVLSHSYCLH 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 180 PSLLRISCSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTacFVYLk 259
Cdd:cd15222 158 QDVMKLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVP--MIGL- 234

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 58801290 260 ppSVVPSISDRLFSVLHTVL-------PPALNPVIYSLR 291
Cdd:cd15222 235 --SMVHRFGKHASPLVHVLManvyllvPPVLNPIIYSVK 271

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

8-296

3.71e-27

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 107.94 E-value: 3.71e-27

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290   8 TGFILMGFSAAPELQTVCGLFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHN 87
Cdd:cd15949   2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  88 NSISILGCALQVFLMTSFASGDVFVLTAMSYDHYVAICCPLHYETIMSSGncvlMVGVSWAIGVLFGALYTAGTFSM--- 164
Cdd:cd15949  82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNT----TVIRIGLAAVIRGVLYISPLPLLvrr 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 165 -PFCGSIVIPQFFCDVPSLLRISCSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHL 243
Cdd:cd15949 158 lPWYRTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHV 237

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 58801290 244 T---VFSVFIVTACFVYLKPPSVVPSISdRLFSVLHTVLPPALNPVIYSLRNSDVK 296
Cdd:cd15949 238 CailAFYVPIAVSSLIHRFGQNVPPPTH-ILLANFYLLIPPMLNPIVYGVRTKQIQ 292

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

27-295

6.30e-27

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 106.87 E-value: 6.30e-27

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFA 106
Cdd:cd15956   5 LPFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFS 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 107 SGDVFVLTAMSYDHYVAICCPLHYETIMSSgNCVLMVGVSWAI-GVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRI 185
Cdd:cd15956  85 AMESGVLVAMALDRFVAICNPLHYATILTL-EVVAKAGLLLALrGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 186 SCSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYL--KPPSV 263
Cdd:cd15956 164 ACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLmhRFGHS 243

                       250       260       270
                ....*....|....*....|....*....|..
gi 58801290 264 VPSISDRLFSVLHTVLPPALNPVIYSLRNSDV 295
Cdd:cd15956 244 VPSAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

29-296

2.94e-26

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 105.37 E-value: 2.94e-26

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  29 FLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFASG 108
Cdd:cd15948   8 FCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIM 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 109 DVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRISCS 188
Cdd:cd15948  88 ESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLACG 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 189 DILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVF---IVTACFVYLKPPSVVP 265
Cdd:cd15948 168 DTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFytpVVLSSTMHRFARHVAP 247

                       250       260       270
                ....*....|....*....|....*....|.
gi 58801290 266 SISdRLFSVLHTVLPPALNPVIYSLRNSDVK 296
Cdd:cd15948 248 HVH-ILLANFYLLFPPMMNPIVYGVKTKQIR 277

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

29-295

6.30e-26

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 104.13 E-value: 6.30e-26

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  29 FLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFASG 108
Cdd:cd15954   7 FCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 109 DVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLRISCS 188
Cdd:cd15954  87 ESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 189 DILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYLKPPSV---VP 265
Cdd:cd15954 167 NIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHRFGghhIT 246

                       250       260       270
                ....*....|....*....|....*....|
gi 58801290 266 SISDRLFSVLHTVLPPALNPVIYSLRNSDV 295
Cdd:cd15954 247 PHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

52-288

6.88e-22

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 92.75 E-value: 6.88e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290    52 KLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNN-SISILGCALQVFLMTSFASGDVFVLTAMSYDHYVAICCPLHY 130
Cdd:pfam00001  14 KLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDwPFGSALCKIVGALFVVNGYASILLLTAISIDRYLAIVHPLRY 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290   131 ETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSiviPQFFCDVPSLLRISCSDILVVIYTSLGMGVCLGMSCFi 210
Cdd:pfam00001  94 KRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEG---NVTVCFIDFPEDLSKPVSYTLLISVLGFLLPLLVILV- 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290   211 cvviSYFYIFSTVLKIPTTKGQS-------KAFATCLPHLTVFSV----FIVTACFVYLKPPSVVPSISDRLFSVLH--T 277
Cdd:pfam00001 170 ----CYTLIIRTLRKSASKQKSSertqrrrKALKTLAVVVVVFILcwlpYHIVNLLDSLALDCELSRLLDKALSVTLwlA 245

                         250
                  ....*....|.
gi 58801290   278 VLPPALNPVIY 288
Cdd:pfam00001 246 YVNSCLNPIIY 256

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

26-295

2.30e-21

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 91.75 E-value: 2.30e-21

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  26 GLFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSF 105
Cdd:cd15955   4 GIPFCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 106 ASGDVFVLTAMSYDHYVAICCPLHYETIMSS---GNCVLMVGVSWAIGVLFGALYTAGTFSmpFCGSIVIPQFFCDVPSL 182
Cdd:cd15955  84 QAFESGILLAMALDRYVAICHPLRHSSILTPqvlLGIGVLVVVRAVVLIIPCPLLIKLRLH--HFRSTVISHSYCEHMAV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 183 LRISCSDILVVIYTSL--GMGVCLGMSCFIcvVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIVTACFVYL-- 258
Cdd:cd15955 162 VKLAADDVRVNKIYGLfvAFSILGFDIIFI--TTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFah 239

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 58801290 259 KPPSVVPSISDRLFSVLHTVLPPALNPVIYSLRNSDV 295
Cdd:cd15955 240 RFGHHVAPYVHILLSNLYLLVPPVLNPIVYGVKTKQI 276

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

27-292

1.13e-17

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 81.57 E-value: 1.13e-17

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFA 106
Cdd:cd00637   3 VLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 107 SGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSllris 186
Cdd:cd00637  83 LASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTL----- 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 187 csdilVVIYTSLGMGVCLGMsCFICVVISYFYIFSTVLK--------------IPTTKGQSKAFATCLPHLTVFSV---- 248
Cdd:cd00637 158 -----SKAYTIFLFVLLFLL-PLLVIIVCYVRIFRKLRRhrrrirssssnssrRRRRRRERKVTKTLLIVVVVFLLcwlp 231

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 58801290 249 -FIVTACFVYLKPPSVVPSISDRLFSVLhTVLPPALNPVIYSLRN 292
Cdd:cd00637 232 yFILLLLDVFGPDPSPLPRILYFLALLL-AYLNSAINPIIYAFFN 275

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

26-299

2.36e-12

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 66.05 E-value: 2.36e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  26 GLFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSF 105
Cdd:cd14967   3 AVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLC 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 106 ASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALytagtfsmpfcgSIVIPQFFCDVPSLLRI 185
Cdd:cd14967  83 CTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLP------------PLVGWRDETQPSVVDCE 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 186 sCSDILVVIYTSLGMGVCLGMSCFICVVIsYFYIFSTVLKipttkgQSKAFATCLPHLTVFSV----FIVTACFVYLKPP 261
Cdd:cd14967 151 -CEFTPNKIYVLVSSVISFFIPLLIMIVL-YARIFRVARR------ELKAAKTLAIIVGAFLLcwlpFFIIYLVSAFCPP 222

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 58801290 262 SVVPSISDRLFSVLHtVLPPALNPVIYSLRNSDVKRAL 299
Cdd:cd14967 223 DCVPPILYAVFFWLG-YLNSALNPIIYALFNRDFRRAF 259

7tmA_EDG-like

cd14972

endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...

52-299

7.91e-08

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 52.68 E-value: 7.91e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  52 KLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFASGDVFVLtAMSYDHYVAICCPLHYE 131
Cdd:cd14972  28 RLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSLLASAYSLL-AIAVDRYISIVHGLTYV 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 132 TIMSSGNCVLMVGVSWAIGVLFGALytagtfsmpfcgsiviPQFFCDVPSLLRISCSDILVviYTSLGMGVCLGMSCFIC 211
Cdd:cd14972 107 NNVTNKRVKVLIALVWVWSVLLALL----------------PVLGWNCVLCDQESCSPLGP--GLPKSYLVLILVFFFIA 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 212 VVI---SYFYIFSTVLK------------IPTTKGQSKAFATCLphLTVFSVFIV--TACFVYLKPPSVVPSISD----- 269
Cdd:cd14972 169 LVIivfLYVRIFWCLWRhanaiaarqeaaVPAQPSTSRKLAKTV--VIVLGVFLVcwLPLLILLVLDVLCPSVCDiqavf 246

                       250       260       270
                ....*....|....*....|....*....|
gi 58801290 270 RLFSVLhTVLPPALNPVIYSLRNSDVKRAL 299
Cdd:cd14972 247 YYFLVL-ALLNSAINPIIYAFRLKEMRRAV 275

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

52-299

2.88e-07

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 51.05 E-value: 2.88e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  52 KLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFASGDVFVLTAMSYDHYVAICCPLHYe 131
Cdd:cd14969  30 KLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGLVSISTLAALAFERYLVIVRPLKA- 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 132 TIMSSGNCVLMVGVSWAIGVLFGalytagtfSMPFCGSIVIpqffcdVPSLLRISCS------DILVVIYTslgmgVCLG 205
Cdd:cd14969 109 FRLSKRRALILIAFIWLYGLFWA--------LPPLFGWSSY------VPEGGGTSCSvdwyskDPNSLSYI-----VSLF 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 206 MSCFI----CVVISYFYIFSTVLKIPTTKGQSKAFATCLPHL-----TVFSVFIVTACFVYLKPP----SVVPSISDRLF 272
Cdd:cd14969 170 VFCFFlplaIIIFCYYKIYRTLRKMSKRAARRKNSAITKRTKkaekkVAKMVLVMIVAFLIAWTPyavvSLYVSFGGEST 249

                       250       260       270
                ....*....|....*....|....*....|....*
gi 58801290 273 SVLHTVLPPAL--------NPVIYSLRNSDVKRAL 299
Cdd:cd14969 250 IPPLLATIPALfaksstiyNPIIYVFMNKQFRRAL 284

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

30-171

4.56e-07

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 50.31 E-value: 4.56e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  30 LVMYVAVImSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCAL----QVFLMtsF 105
Cdd:cd15196   9 TILVLALF-GNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALFNVLPQLIWDITYRFYGGDLLCRLvkylQVVGM--Y 85

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 58801290 106 ASGdvFVLTAMSYDHYVAICCPLHYETImSSGNCVLMVGVSWAIGVLFgALYTAGTFSMPFCGSIV 171
Cdd:cd15196  86 ASS--YVLVATAIDRYIAICHPLSSHRW-TSRRVHLMVAIAWVLSLLL-SIPQLFIFSYQEVGSGV 147

7tmA_photoreceptors_insect

cd15079

insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...

26-156

1.24e-06

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320207 [Multi-domain] Cd Length: 292 Bit Score: 49.11 E-value: 1.24e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  26 GLFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDiFFISVPIPNFFINSITHNNSISILGCALQVFLMTSF 105
Cdd:cd15079   4 GFIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISD-FLMMIKMPIFIYNSFYEGWALGPLGCQIYAFLGSLS 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 58801290 106 ASGDVFVLTAMSYDHYVAICCPLHyETIMSSGNCVLMVGVSWAIGVLFGAL 156
Cdd:cd15079  83 GIGSIWTNAAIAYDRYNVIVKPLN-GNPLTRGKALLLILFIWLYALPWALL 132

7tmA_NTSR-like

cd14979

neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...

27-153

1.73e-06

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320110 [Multi-domain] Cd Length: 300 Bit Score: 48.89 E-value: 1.73e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSI-THNNSISILGCALQVFLMTSF 105
Cdd:cd14979   5 AIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWwQYPWAFGDGGCKLYYFLFEAC 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 58801290 106 ASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLF 153
Cdd:cd14979  85 TYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILC 132

7tmA_CCKR-like

cd14993

cholecystokinin receptors and related proteins, member of the class A family of ...

23-178

2.02e-06

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.

Pssm-ID: 320124 [Multi-domain] Cd Length: 296 Bit Score: 48.75 E-value: 2.02e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  23 TVCGLFFLVMYVAVImSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLM 102
Cdd:cd14993   2 VLIVLYVVVFLLALV-GNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQ 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 58801290 103 TSFASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSW--AIGVLFGALYTAGTFSMPFCGSIVIPQFFCD 178
Cdd:cd14993  81 GVSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWviAIIIMLPLLVVYELEEIISSEPGTITIYICT 158

7tmA_Mel1A

cd15402

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...

23-297

4.07e-06

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.

Pssm-ID: 320524 [Multi-domain] Cd Length: 279 Bit Score: 47.59 E-value: 4.07e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  23 TVCGLFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPnFFINSITHNN-SISILGCALQVFL 101
Cdd:cd15402   1 TALACILIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYP-LVLTSIFHNGwNLGYLHCQISGFL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 102 MTSFASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVL-------FGAL-YTAGTFSMPFCGSivip 173
Cdd:cd15402  80 MGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWVLTVAaivpnlfVGSLqYDPRIYSCTFAQS---- 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 174 qffcdvpsllrISCSDILVVIYTSLGMGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIV-- 251
Cdd:cd15402 156 -----------VSSAYTIAVVFFHFILPIIIVTFCYLRIWILVIQVRRRVKPDNKPKLKPHDFRNFVTMFVVFVLFAVcw 224

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 58801290 252 -----TACFVYLKPPSVVPSISDRLF--SVLHTVLPPALNPVIYSLRNSDVKR 297
Cdd:cd15402 225 aplnfIGLAVAVDPETIVPRIPEWLFvaSYYMAYFNSCLNAIIYGLLNQNFRR 277

7tmA_Melanopsin

cd15336

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...

26-220

7.44e-06

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320458 [Multi-domain] Cd Length: 290 Bit Score: 47.02 E-value: 7.44e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  26 GLFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSF 105
Cdd:cd15336   4 GSVILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 106 ASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWaigvlfgaLYTAGTFSMPFCGsivipqFFCDVPSLLRI 185
Cdd:cd15336  84 GITSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVW--------LYSLAWSLPPLFG------WSAYVPEGLLT 149

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 58801290 186 SCS-DIL-----VVIYTslgMGVCLGMSCFICVVISYFYIF 220
Cdd:cd15336 150 SCTwDYMtftpsVRAYT---MLLFCFVFFIPLGIIIYCYLF 187

7tmA_Melanopsin-like

cd15083

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...

23-299

7.96e-06

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320211 [Multi-domain] Cd Length: 291 Bit Score: 46.94 E-value: 7.96e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  23 TVCGLFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLM 102
Cdd:cd15083   1 YVLGIFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 103 TSFASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWaigvlfgaLYTAGTFSMPFCGsivipqFFCDVPSL 182
Cdd:cd15083  81 GLFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVW--------LYSLLWVLPPLFG------WSRYVLEG 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 183 LRISCS-DILVVIYTSLGMGVCLGMSCF---ICVVI-SYFYIFSTV----------LKIPTTKGQSKAFATCLP--HLTV 245
Cdd:cd15083 147 LLTSCSfDYLSRDDANRSYVICLLIFGFvlpLLIIIyCYSFIFRAVrrhekamkemAKRFSKSELSSPKARRQAevKTAK 226

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 58801290 246 FSVFIVTACFVYLKPPSVVPSISdrLFSVLHTVLP-----PAL--------NPVIYSLRNSDVKRAL 299
Cdd:cd15083 227 IALLLVLLFCLAWTPYAVVALIG--QFGYLEVLTPlataiPAAfaktsaiyNPVIYAFSHPKFRRAL 291

7tmA_Mel1C

cd15401

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...

29-297

4.28e-05

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.

Pssm-ID: 320523 [Multi-domain] Cd Length: 279 Bit Score: 44.52 E-value: 4.28e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  29 FLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFASG 108
Cdd:cd15401   7 LIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLMGLSVIG 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 109 DVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVlfgalytAGTFSMPFCGSIVI-PQFF-CDVPSLLRIS 186
Cdd:cd15401  87 SVFNITAIAINRYCYICHSLRYDKLYNMKKTCCYVCLTWVLTL-------AAIVPNFFVGSLQYdPRIYsCTFAQTVSSS 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 187 CSDILVVIYTSLGMGVclgmscficVVISYFYIFSTVLKIP---TTKGQSKAFATCLPH-LTVFSVFIVTA-CF------ 255
Cdd:cd15401 160 YTITVVVVHFIVPLSI---------VTFCYLRIWVLVIQVKhrvRQDSKQKLKANDIRNfLTMFVVFVLFAvCWgplnfi 230

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 58801290 256 ---VYLKPPSVVPSISDRLF--SVLHTVLPPALNPVIYSLRNSDVKR 297
Cdd:cd15401 231 glaVAINPLKVAPKIPEWLFvlSYFMAYFNSCLNAVIYGVLNQNFRK 277

7tmA_TAAR2_3_4

cd15312

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...

27-221

8.45e-05

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320437 [Multi-domain] Cd Length: 289 Bit Score: 43.50 E-value: 8.45e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFA 106
Cdd:cd15312   5 LFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLDMMLS 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 107 SGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSW------AIGVLFGALYTAGTFSMpfcgsivipqffcdvp 180
Cdd:cd15312  85 TTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWsvpclfAFGVVFSEVNLEGIEDY---------------- 148

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 58801290 181 sLLRISCSDILVVIYTSLgMGVCLGMSCFI---CVVIS-YFYIFS 221
Cdd:cd15312 149 -VALVSCTGSCVLIFNKL-WGVIASLIAFFipgTVMIGiYIKIFF 191

7tmA_Mel1

cd15209

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...

30-297

1.35e-04

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.

Pssm-ID: 320337 [Multi-domain] Cd Length: 279 Bit Score: 42.84 E-value: 1.35e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  30 LVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPnFFINSITHNN-SISILGCALQVFLMTSFASG 108
Cdd:cd15209   8 IVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYP-LILHAIFHNGwTLGQLHCQASGFIMGLSVIG 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 109 DVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLfgalytaGTFSMPFCGSIVI-PQFF-CDVPSLLRIS 186
Cdd:cd15209  87 SIFNITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWLLTVL-------AVLPNFFIGSLQYdPRIYsCTFAQTVSTV 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 187 CSDILVVIYTSLGMGVclgmscficVVISYFYIFSTVLKI-----PTTKGQSKAfATCLPHLTVFSVFIVTA-CF----- 255
Cdd:cd15209 160 YTITVVVIHFLLPLLI---------VSFCYLRIWVLVLQVrqrvkPDQRPKLKP-ADVRNFLTMFVVFVLFAvCWaplnf 229

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 58801290 256 ----VYLKPPSVVPSISDRLF--SVLHTVLPPALNPVIYSLRNSDVKR 297
Cdd:cd15209 230 iglaVAINPKEMAPKIPEWLFvaSYFMAYFNSCLNAIIYGLLNQNFRK 277

7tmA_TAAR5

cd15318

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...

34-157

1.50e-04

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320441 [Multi-domain] Cd Length: 282 Bit Score: 42.92 E-value: 1.50e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  34 VAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFASGDVFVL 113
Cdd:cd15318  12 LIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFHL 91

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 58801290 114 TAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALY 157
Cdd:cd15318  92 CFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVPTVYTSVF 135

7tmA_SREB-like

cd15005

super conserved receptor expressed in brain and related proteins, member of the class A family ...

53-152

3.18e-04

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320134 [Multi-domain] Cd Length: 329 Bit Score: 42.06 E-value: 3.18e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  53 LQTPMYFFLKNLSLLDIFFISVPIPnFFINSITHNNS--ISILGCALQVFLMTSFASGDVFVLTAMSYDHYVAICCPLHY 130
Cdd:cd15005  31 LHRAPYYFLLDLCLADGLRSLACFP-FVMASVRHGSGwiYGALSCKVIAFLAVLFCFHSAFTLFCIAVTRYMAIAHHRFY 109

                        90       100
                ....*....|....*....|..
gi 58801290 131 ETIMSSGNCVLMVGVSWAIGVL 152
Cdd:cd15005 110 AKRMTFWTCLAVICMAWTLSVA 131

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

52-299

3.57e-04

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 41.47 E-value: 3.57e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  52 KLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNnsISILGCALQVFLMTSFASGDVFVLTAMSYDHYVAICCPLHYE 131
Cdd:cd14968  30 ALRTVTNYFIVSLAVADILVGALAIPLAILISLGLP--TNFHGCLFMACLVLVLTQSSIFSLLAIAIDRYLAIKIPLRYK 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 132 TIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFfcdvpsllrISCSDILVVIYTSLgmgvcLGMSCFIC 211
Cdd:cd14968 108 SLVTGRRAWGAIAVCWVLSFLVGLTPMFGWNNGAPLESGCGEGG---------IQCLFEEVIPMDYM-----VYFNFFAC 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 212 VVIS-------YFYIFSTVLK----IPTTKGQSKAFATCLPHL-TVFSVFIVTACFV-------------YLKPPSVVPS 266
Cdd:cd14968 174 VLVPllimlviYLRIFRVIRKqlrqIESLLRSRRSRSTLQKEVkAAKSLAIILFLFAlcwlplhiincitLFCPECKVPK 253

                       250       260       270
                ....*....|....*....|....*....|...
gi 58801290 267 ISdRLFSVLHTVLPPALNPVIYSLRNSDVKRAL 299
Cdd:cd14968 254 IL-TYIAILLSHANSAVNPIVYAYRIRKFRQTF 285

7tmA_NPR-like_invertebrate

cd15391

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...

37-156

4.49e-04

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.

Pssm-ID: 320513 [Multi-domain] Cd Length: 289 Bit Score: 41.35 E-value: 4.49e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  37 IMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFASGDVFVLTAM 116
Cdd:cd15391  15 VGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLVSVTASVLTNTAI 94

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 58801290 117 SYDHYVAICCPLHYETIMSSGNCVlmVGVSWAIGVLFGAL 156
Cdd:cd15391  95 GIDRFFAVIFPLRSRHTKSRTKCI--IASIWAISFSLSSV 132

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

52-219

5.06e-04

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 41.00 E-value: 5.06e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  52 KLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFASGDVFVLTAMSYDHYVAICCPLHYE 131
Cdd:cd15055  30 QLHTPTNLLLLSLAVADFLVGLLVMPFSMIRSIETCWYFGDTFCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYP 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 132 TIMSSGNCVLMVGVSWAIGVLFgalytagtfsmpfcgSIVIPQFFCDVPSLLR-ISCSDILVVIYtSLGMGVCLGMSCFI 210
Cdd:cd15055 110 TKITIRRVKICICLCWFVSALY---------------SSVLLYDNLNQPGLIRyNSCYGECVVVV-NFIWGVVDLVLTFI 173

                       170
                ....*....|.
gi 58801290 211 --CVVISYFYI 219
Cdd:cd15055 174 lpCTVMIVLYM 184

7tmA_Adenosine_R_A2B

cd15069

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...

30-154

7.99e-04

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320197 [Multi-domain] Cd Length: 294 Bit Score: 40.69 E-value: 7.99e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  30 LVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPnfFINSITHNNSISILGCALQVFLMTSFASGD 109
Cdd:cd15069   8 LIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIP--FAITISLGFCTDFHSCLFLACFVLVLTQSS 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 58801290 110 VFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFG 154
Cdd:cd15069  86 IFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIG 130

7tmA_V1aR

cd15385

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...

31-155

1.08e-03

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320507 [Multi-domain] Cd Length: 301 Bit Score: 40.19 E-value: 1.08e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  31 VMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDI---FFISVPI-----------PNFFINSITHnnsisilgca 96
Cdd:cd15385   9 VIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLvvaFFQVLPQlcwdityrfygPDFLCRIVKH---------- 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  97 LQVFLMtsFASgdVFVLTAMSYDHYVAICCPLhyETI-MSSGNCVLMVGVSWAIGVLFGA 155
Cdd:cd15385  79 LQVLGM--FAS--TYMLVMMTADRYIAICHPL--KTLqQPTKRSYLMIGSAWALSFILST 132

7tmA_SREB3_GPR173

cd15217

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...

58-162

1.10e-03

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320345 [Multi-domain] Cd Length: 329 Bit Score: 40.32 E-value: 1.10e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  58 YFFLKNLSLLDIFFISVPIPnFFINSITHNNS--ISILGCALQVFLMTSFASGDVFVLTAMSYDHYVAICCPLHYETIMS 135
Cdd:cd15217  36 YYFLLDLCLADTIRSAVCFP-FVLVSIRNGSAwtYSVLSCKIVAFMAVLFCFHAAFMLFCISVTRYMAIAHHRFYSKRMT 114

                        90       100
                ....*....|....*....|....*....
gi 58801290 136 SGNCVLMVGVSWAIGV--LFGALYTAGTF 162
Cdd:cd15217 115 FWTCIAVICMVWTLSVamAFPPVFDVGTY 143

7tmA_BNGR-A34-like

cd15000

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...

53-152

1.27e-03

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320131 [Multi-domain] Cd Length: 285 Bit Score: 40.10 E-value: 1.27e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  53 LQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFASGDVFVLTAMSYDHYVAICCPLhyET 132
Cdd:cd15000  30 LRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGFLEGSLLLASVLALCAVSYDRLTAIVLPS--EA 107

                        90       100
                ....*....|....*....|
gi 58801290 133 IMSSGNCVLMVGVSWAIGVL 152
Cdd:cd15000 108 RLTKRGAKIVIVITWIVGLL 127

7tmA_ETH-R

cd14997

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...

27-154

1.61e-03

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320128 [Multi-domain] Cd Length: 294 Bit Score: 39.58 E-value: 1.61e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINsiTHNNSISILG---CALQVFLMT 103
Cdd:cd14997   5 VVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVE--TWAREPWLLGefmCKLVPFVEL 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 58801290 104 SFASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFG 154
Cdd:cd14997  83 TVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTS 133

7tmA_S1PR2_Edg5

cd15347

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial ...

27-297

1.93e-03

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).

Pssm-ID: 320469 [Multi-domain] Cd Length: 266 Bit Score: 39.41 E-value: 1.93e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSithNNSISILGCALQVFLMTSFA 106
Cdd:cd15347   5 IFIVILCCIIVLENLLVLIAVARNKKFHSAMFFFIGNLAFSDLLAGVAFIANILLSG---SVTFRLTPVQWFIREGTAFI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 107 --SGDVFVLTAMSYDHYVAIccpLHYETIMSSGNC--VLMVGVSWAIGVLFGALYTAG---TFSMPFCgSIVIPQFfcdv 179
Cdd:cd15347  82 tlSASVFSLLAIAIERHVAI---TKVKLYGSDKNCrmVLLIGACWVISIVLGGLPILGwncIGNLEDC-STVLPLY---- 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 180 pSLLRISCsdiLVVIYTSLgmgvclgmscFICVVISYFYIFSTVLKIPTTKGQSKAFATCLPHLTVFSVFIV-------- 251
Cdd:cd15347 154 -SKHYILF---VVTIFSII----------LLSIVILYVRIYCIVRSSHAEMAAPQTLALLKTVTIVLGVFIVcwlpafii 219

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 58801290 252 ----TACFVYLKPpsvVPSISDRLFSVlhTVLPPALNPVIYSLRNSDVKR 297
Cdd:cd15347 220 llldTSCKVKSCP---ILYKADYFFSV--ATLNSALNPVIYTLRSKDMRK 264

7tmA_Mel1B

cd15400

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...

52-297

2.22e-03

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.

Pssm-ID: 320522 [Multi-domain] Cd Length: 279 Bit Score: 39.07 E-value: 2.22e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  52 KLQTPMYFFLKNLSLLDIFFISVPIPnFFINSITHNN-SISILGCALQVFLMTSFASGDVFVLTAMSYDHYVAICCPLHY 130
Cdd:cd15400  30 KLRNSGNVFVVSLALADLVVALYPYP-LVLVAIFHNGwALGEMHCKVSGFVMGLSVIGSIFNITGIAINRYCYICHSFAY 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 131 ETIMSSGNCVLMVGVSWAIGVLfgalytagtfsmpfcgsIVIPQFFcdVPSLL---RISCSDILVVIYTSLGMGVCLGMS 207
Cdd:cd15400 109 DKLYSRWNTLLYVCLIWALTVV-----------------AIVPNFF--VGSLEydpRIYSCTFVQTASSSYTIAVVVIHF 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 208 CFICVVISYFYIFSTVLKIPTTKGQSKAFATCLP------HLTVFSVFIVTA-CF---------VYLKPPSVVPSISDRL 271
Cdd:cd15400 170 IVPITVVSFCYLRIWVLVIQVRRKVKSESKPRLKpsdfrnFLTMFVVFVIFAiCWaplnliglaVAINPQEMAPKVPEWL 249

                       250       260
                ....*....|....*....|....*...
gi 58801290 272 F--SVLHTVLPPALNPVIYSLRNSDVKR 297
Cdd:cd15400 250 FvvSYFMAYFNSCLNAIIYGLLNQNFRK 277

7tmA_Gal2_Gal3_R

cd15097

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...

60-157

2.33e-03

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.

Pssm-ID: 320225 [Multi-domain] Cd Length: 279 Bit Score: 39.04 E-value: 2.33e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  60 FLKNLSLLDIFFISVPIP-NFFINSITHNNSISILGCALQVFL-MTSFASGdvFVLTAMSYDHYVAICCPLHYETIMSSG 137
Cdd:cd15097  39 FILNLSVADLCFILFCVPfQATIYSLEGWVFGSFLCKAVHFFIyLTMYASS--FTLAAVSVDRYLAIRYPLRSRELRTPR 116

                        90       100
                ....*....|....*....|
gi 58801290 138 NCVLMVGVSWAIGVLFGALY 157
Cdd:cd15097 117 NAVAAIALIWGLSLLFAGPY 136

7tmA_GPR26_GPR78-like

cd15219

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...

60-153

2.33e-03

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320347 [Multi-domain] Cd Length: 264 Bit Score: 38.98 E-value: 2.33e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  60 FLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNC 139
Cdd:cd15219  38 FLLNLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLETFLTSNAMLSMAALSIDRWIAVVFPLSYTSKMRYRDA 117

                        90
                ....*....|....
gi 58801290 140 VLMVGVSWAIGVLF 153
Cdd:cd15219 118 ALMVGYSWLHSLTF 131

7tmA_Prostanoid_R

cd14981

G protein-coupled receptors for prostanoids, member of the class A family of ...

100-156

2.69e-03

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.

Pssm-ID: 320112 [Multi-domain] Cd Length: 288 Bit Score: 38.77 E-value: 2.69e-03

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 58801290 100 FLMTSFASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGAL 156
Cdd:cd14981  81 FMMSFFGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIASL 137

7tmA_Octopamine_R

cd15063

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...

31-298

3.39e-03

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.

Pssm-ID: 320191 [Multi-domain] Cd Length: 266 Bit Score: 38.63 E-value: 3.39e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  31 VMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFASGDV 110
Cdd:cd15063   9 FLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWMCTASI 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 111 FVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFgalytagtFSMPFCGSIVIPQFFCDVPSLLRISCSDI 190
Cdd:cd15063  89 LNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVI--------CFPPLVGWNDGKDGIMDYSGSSSLPCTCE 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 191 LV-----VIYTSLGmgvclgmSCFICVVISYFYIFSTVLKIPTTKGQSKAFAtclphlTVFSVFIVTAC---FVYLKPPS 262
Cdd:cd15063 161 LTngrgyVIYSALG-------SFYIPMLVMLFFYFRIYRAARMETKAAKTVA------IIVGCFIFCWLpffTVYLVRAF 227

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 58801290 263 VVPSISDRLFSVLHTV--LPPALNPVIYSLRNSDVKRA 298
Cdd:cd15063 228 CEDCIPPLLFSVFFWLgyCNSALNPCIYALFSRDFRFA 265

7tmA_TAAR1

cd15314

trace amine-associated receptor 1 and similar receptors, member of the class A family of ...

110-154

3.41e-03

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320438 [Multi-domain] Cd Length: 282 Bit Score: 38.76 E-value: 3.41e-03

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 58801290 110 VFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFG 154
Cdd:cd15314  88 ILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALVG 132

7tmA_5-HT2A

cd15304

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...

27-151

3.47e-03

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341345 [Multi-domain] Cd Length: 267 Bit Score: 38.37 E-value: 3.47e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSIT-HNNSISILGCALQVFLMTSF 105
Cdd:cd15304   5 LLTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYgYRWPLPSKLCAVWIYLDVLF 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 58801290 106 ASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGV 151
Cdd:cd15304  85 STASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISV 130

7tmA_FMRFamide_R-like

cd14978

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...

52-153

4.17e-03

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.

Pssm-ID: 410630 [Multi-domain] Cd Length: 299 Bit Score: 38.38 E-value: 4.17e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  52 KLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNS-------ISILGCALQVFLMTSFASgdVFVLTAMSYDHYVAI 124
Cdd:cd14978  29 SMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSsflsyfyAYFLPYIYPLANTFQTAS--VWLTVALTVERYIAV 106

                        90       100
                ....*....|....*....|....*....
gi 58801290 125 CCPLHYETIMSSGNCVLMVGVSWAIGVLF 153
Cdd:cd14978 107 CHPLKARTWCTPRRARRVILIIIIFSLLL 135

7tm_GPCRs

cd14964

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...

25-292

4.63e-03

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410628 [Multi-domain] Cd Length: 267 Bit Score: 38.18 E-value: 4.63e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  25 CGLFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTS 104
Cdd:cd14964   1 TTIILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 105 FASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVPSLLR 184
Cdd:cd14964  81 ANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGAIPRYNTLTGSCYLICTTIYLT 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 185 ISCSDILVVIytslgmGVCLGMSCFICVVISYFYIFSTVLKIPTTKGQ--SKAFATCLPHLTVFSVFIVTACFVYLKPPS 262
Cdd:cd14964 161 WGFLLVSFLL------PLVAFLVIFSRIVLRLRRRVRAIRSAASLNTDknLKATKSLLILVITFLLCWLPFSIVFILHAL 234

                       250       260       270
                ....*....|....*....|....*....|...
gi 58801290 263 VVPSISDRLFSVLHT---VLPPALNPVIYSLRN 292
Cdd:cd14964 235 VAAGQGLNLLSILANllaVLASTLNPFIYCLGN 267

7tmA_Gal1_R

cd15098

galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...

60-157

5.11e-03

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.

Pssm-ID: 320226 [Multi-domain] Cd Length: 282 Bit Score: 38.17 E-value: 5.11e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  60 FLKNLSLLDIFFISVPIPnffINSITHNNSISILG---CALQVFLMTSFASGDVFVLTAMSYDHYVAICCPLHYETIMSS 136
Cdd:cd15098  40 FILNLSIADLFFLLFCVP---FQATIYSLPEWVFGafmCKFVHYFFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTR 116

                        90       100
                ....*....|....*....|.
gi 58801290 137 GNCVLMVGVSWAIGVLFGALY 157
Cdd:cd15098 117 RNALLGVLVIWVLSLAMASPV 137

7tmA_mAChR_M3

cd15299

muscarinic acetylcholine receptor subtype M3, member of the class A family of ...

31-182

5.70e-03

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320426 [Multi-domain] Cd Length: 274 Bit Score: 38.01 E-value: 5.70e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  31 VMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFfISVPIPNFFINSITHNN-SISILGCALQVFLMTSFASGD 109
Cdd:cd15299  12 ILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLI-IGVISMNLFTTYIIMNRwALGNLACDLWLSIDYVASNAS 90

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 58801290 110 VFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFGAlyTAGTFSMPFCGSIVIPQFFCDVPSL 182
Cdd:cd15299  91 VMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWA--PAILFWQYFVGKRTVPPDECFIQFL 161

7tmA_QRFPR

cd15205

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...

27-154

8.03e-03

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.

Pssm-ID: 320333 [Multi-domain] Cd Length: 298 Bit Score: 37.45 E-value: 8.03e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  27 LFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFA 106
Cdd:cd15205   5 ITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPFVQSTAV 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 58801290 107 SGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWAIGVLFG 154
Cdd:cd15205  85 VTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVG 132

7tmA_alpha1A_AR

cd15325

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...

24-154

8.51e-03

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320448 [Multi-domain] Cd Length: 261 Bit Score: 37.18 E-value: 8.51e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  24 VCGLFFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMT 103
Cdd:cd15325   2 VLGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDV 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 58801290 104 SFASGDVFVLTAMSYDHYVAICCPLHYETIMSSGNCVLMVGVSWA------IGVLFG 154
Cdd:cd15325  82 LCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVlslvisIGPLFG 138

7tmA_NPSR

cd15197

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...

28-299

9.74e-03

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).

Pssm-ID: 320325 [Multi-domain] Cd Length: 294 Bit Score: 37.40 E-value: 9.74e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  28 FFLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFAS 107
Cdd:cd15197   6 TLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVLTDIIWRITVEWRAGDFACKVIRYLQVVVTY 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 108 GDVFVLTAMSYDHYVAICCPLHYETimSSGNCVLMVGVSWAIGVLFGA----LYTAGTFSMPfcgsivIPQFFCDVPS-- 181
Cdd:cd15197  86 ASTYVLVALSIDRYDAICHPMNFSQ--SGRQARVLICVAWILSALFSIpmliIFEKTGLSNG------EVQCWILWPEpw 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 182 --LLRISCSDILVVIYTSLGMGVCLGmscFICVVI-SYFYIFSTVLKIPTTKGQSKAFAT--CLPH---------LTVFS 247
Cdd:cd15197 158 ywKVYMTIVAFLVFFIPATIISICYI---IIVRTIwKKSKIQVTINKAGLHDGSSRRSSSrgIIPRakiktikmtFVIVT 234

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290 248 VFIVTAC----FVYLKPPSVVPSISDRLF-SVLHTVLPP---ALNPVIYSLRNSDVKRAL 299
Cdd:cd15197 235 VFIICWSpyfvFDLLDVFGLLPRSKTKIAaATFIQSLAPlnsAINPLIYCLFSTHLCRPL 294

7tmA_TACR

cd15390

neurokinin receptors (or tachykinin receptors), member of the class A family of ...

29-180

9.80e-03

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320512 [Multi-domain] Cd Length: 289 Bit Score: 37.27 E-value: 9.80e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801290  29 FLVMYVAVIMSNLLLITLITLDLKLQTPMYFFLKNLSLLDIFFISVPIPNFFINSITHNNSISILGCALQVFLMTSFASG 108
Cdd:cd15390   7 FVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAITTVAA 86

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 58801290 109 DVFVLTAMSYDHYVAICCPLHYEtiMSSGNCVLMVGVSW--AIGVLFGALYTAGTFSMPFCGSIVIPQFFCDVP 180
Cdd:cd15390  87 SVFTLMAISIDRYIAIVHPLRPR--LSRRTTKIAIAVIWlaSFLLALPQLLYSTTETYYYYTGSERTVCFIAWP 158

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01