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Conserved domains on  [gi|222831633|ref|NP_001010904|]
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glycine N-acyltransferase-like protein 3 [Homo sapiens]

Protein Classification

glycine N-acyltransferase family protein( domain architecture ID 10532672)

glycine N-acyltransferase family protein may transfer an acyl group to the N-terminus of glutamine; similar to mouse glycine N-acyltransferase-like protein 3 (GLYATL3) which catalyzes the conjugation of long-chain fatty acyl-CoA thioester and glycine to produce long-chain N-(fatty acyl)glycine, in the primary fatty acid amide biosynthetic pathway

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gly_acyl_tr_N pfam06021
Aralkyl acyl-CoA:amino acid N-acyltransferase; This family consists of several mammalian ...
 1-190 2.10e-115

Aralkyl acyl-CoA:amino acid N-acyltransferase; This family consists of several mammalian specific aralkyl acyl-CoA:amino acid N-acyltransferase (glycine N-acyltransferase) proteins EC:2.3.1.13.


:

Pssm-ID: 461802  Cd Length: 203  Bit Score: 330.31  E-value: 2.10e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831633    1 MLVLNCSTKLLILEKMLKSCFPESLKVYGAVMNINRGNPFQKEVVLDSWPDFKAVITRRQREAETDNLDHYTNAYAVFYK 80
Cdd:pfam06021   1 MLVLQCPQKLQTLEKSLRKSLPESLKVYGAVFHINRGNPFNLEVLVDSWPDFQTVITRPQKEEMTDDLDHYTNTYAIFYK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831633   81 DVRAYRQLLEECDVFNWDQVFQIQGLQSELYDVSKAVANSKQLNIKLTSFKAVHFSPVSSLPDTSFL------------- 147
Cdd:pfam06021  81 DPDALQELLESPDVINWKQHFQIQGCQSSLDEVIQEVAASKSVQVKYTKYILYMTPDPAKLLTPSLLdaknlspsgkpka 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 222831633  148 KGPSPRLTYLSVANADLLNRTWSRGGNEQCLRYIANLISCFPS 190
Cdd:pfam06021 161 NQEMFKLSSLDVSHAALVNETWSFGGNERSLRYIERCIQNFPS 203
NAT_SF super family cl17182
N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of ...
 191-279 3.98e-14

N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase which catalyze the transfer of an acetyl group to a substrate. The mechanism is an ordered Bi-Bi ternary complex kinetic mechanism for most GNATs: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and then CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/ph enylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


The actual alignment was detected with superfamily member pfam08444:

Pssm-ID: 473072  Cd Length: 89  Bit Score: 66.70  E-value: 3.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831633  191 VCVRDEKGNPVSWSITDQFATMCHGYTLPEHRRKGYSRLVALTLARKLQSRGFPSQGNVLDDNTASISLLKSLHAEFLPC 270
Cdd:pfam08444   1 FCLLGPEGTPVSWSLMDQTGELRMAGTLPKYRRQGLMSHVIYHQAQYLEKLGFPVYSHVDKANEISQKMSGNLGHVPMPC 80


                  ....*....
gi 222831633  271 RFHRLILTP 279
Cdd:pfam08444  81 GWNQWNCVP 89
 
Name Accession Description Interval E-value
Gly_acyl_tr_N pfam06021
Aralkyl acyl-CoA:amino acid N-acyltransferase; This family consists of several mammalian ...
 1-190 2.10e-115

Aralkyl acyl-CoA:amino acid N-acyltransferase; This family consists of several mammalian specific aralkyl acyl-CoA:amino acid N-acyltransferase (glycine N-acyltransferase) proteins EC:2.3.1.13.


Pssm-ID: 461802  Cd Length: 203  Bit Score: 330.31  E-value: 2.10e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831633    1 MLVLNCSTKLLILEKMLKSCFPESLKVYGAVMNINRGNPFQKEVVLDSWPDFKAVITRRQREAETDNLDHYTNAYAVFYK 80
Cdd:pfam06021   1 MLVLQCPQKLQTLEKSLRKSLPESLKVYGAVFHINRGNPFNLEVLVDSWPDFQTVITRPQKEEMTDDLDHYTNTYAIFYK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831633   81 DVRAYRQLLEECDVFNWDQVFQIQGLQSELYDVSKAVANSKQLNIKLTSFKAVHFSPVSSLPDTSFL------------- 147
Cdd:pfam06021  81 DPDALQELLESPDVINWKQHFQIQGCQSSLDEVIQEVAASKSVQVKYTKYILYMTPDPAKLLTPSLLdaknlspsgkpka 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 222831633  148 KGPSPRLTYLSVANADLLNRTWSRGGNEQCLRYIANLISCFPS 190
Cdd:pfam06021 161 NQEMFKLSSLDVSHAALVNETWSFGGNERSLRYIERCIQNFPS 203
Gly_acyl_tr_C pfam08444
Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region; This family features the ...
 191-279 3.98e-14

Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region; This family features the C-terminal region of several mammalian specific aralkyl acyl-CoA:amino acid N-acyltransferase (glycine N-acyltransferase) proteins EC:2.3.1.13.


Pssm-ID: 117021  Cd Length: 89  Bit Score: 66.70  E-value: 3.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831633  191 VCVRDEKGNPVSWSITDQFATMCHGYTLPEHRRKGYSRLVALTLARKLQSRGFPSQGNVLDDNTASISLLKSLHAEFLPC 270
Cdd:pfam08444   1 FCLLGPEGTPVSWSLMDQTGELRMAGTLPKYRRQGLMSHVIYHQAQYLEKLGFPVYSHVDKANEISQKMSGNLGHVPMPC 80


                  ....*....
gi 222831633  271 RFHRLILTP 279
Cdd:pfam08444  81 GWNQWNCVP 89
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
216-263 5.12e-06

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 43.74  E-value: 5.12e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 222831633 216 YTLPEHRRKGYSRLVALTLARKLQSRGFPS-QGNVLDDNTASISLLKSL 263
Cdd:COG3393   22 YTHPEYRGRGLASALVAALAREALARGARTpFLYVDADNPAARRLYERL 70
 
Name Accession Description Interval E-value
Gly_acyl_tr_N pfam06021
Aralkyl acyl-CoA:amino acid N-acyltransferase; This family consists of several mammalian ...
 1-190 2.10e-115

Aralkyl acyl-CoA:amino acid N-acyltransferase; This family consists of several mammalian specific aralkyl acyl-CoA:amino acid N-acyltransferase (glycine N-acyltransferase) proteins EC:2.3.1.13.


Pssm-ID: 461802  Cd Length: 203  Bit Score: 330.31  E-value: 2.10e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831633    1 MLVLNCSTKLLILEKMLKSCFPESLKVYGAVMNINRGNPFQKEVVLDSWPDFKAVITRRQREAETDNLDHYTNAYAVFYK 80
Cdd:pfam06021   1 MLVLQCPQKLQTLEKSLRKSLPESLKVYGAVFHINRGNPFNLEVLVDSWPDFQTVITRPQKEEMTDDLDHYTNTYAIFYK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831633   81 DVRAYRQLLEECDVFNWDQVFQIQGLQSELYDVSKAVANSKQLNIKLTSFKAVHFSPVSSLPDTSFL------------- 147
Cdd:pfam06021  81 DPDALQELLESPDVINWKQHFQIQGCQSSLDEVIQEVAASKSVQVKYTKYILYMTPDPAKLLTPSLLdaknlspsgkpka 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 222831633  148 KGPSPRLTYLSVANADLLNRTWSRGGNEQCLRYIANLISCFPS 190
Cdd:pfam06021 161 NQEMFKLSSLDVSHAALVNETWSFGGNERSLRYIERCIQNFPS 203
Gly_acyl_tr_C pfam08444
Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region; This family features the ...
 191-279 3.98e-14

Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region; This family features the C-terminal region of several mammalian specific aralkyl acyl-CoA:amino acid N-acyltransferase (glycine N-acyltransferase) proteins EC:2.3.1.13.


Pssm-ID: 117021  Cd Length: 89  Bit Score: 66.70  E-value: 3.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831633  191 VCVRDEKGNPVSWSITDQFATMCHGYTLPEHRRKGYSRLVALTLARKLQSRGFPSQGNVLDDNTASISLLKSLHAEFLPC 270
Cdd:pfam08444   1 FCLLGPEGTPVSWSLMDQTGELRMAGTLPKYRRQGLMSHVIYHQAQYLEKLGFPVYSHVDKANEISQKMSGNLGHVPMPC 80


                  ....*....
gi 222831633  271 RFHRLILTP 279
Cdd:pfam08444  81 GWNQWNCVP 89
FR47 pfam08445
FR47-like protein; The members of this family are similar to the C-terminal region of the D. ...
 193-263 9.21e-09

FR47-like protein; The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.


Pssm-ID: 117022 [Multi-domain]  Cd Length: 86  Bit Score: 51.56  E-value: 9.21e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 222831633  193 VRDEKGNPVSWSITDQFATMCHGYTLPEHRRKGYSRLVALTLARKLQSRGFPSQGNVLDDNTASISLLKSL 263
Cdd:pfam08445   5 YRGDTGELAAWCLRLPGGELGALQTLPEHRRRGLGSRLVAALARGIAERGITPFAVVVAGNTPSRRLYEKL 75
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
216-263 5.12e-06

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 43.74  E-value: 5.12e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 222831633 216 YTLPEHRRKGYSRLVALTLARKLQSRGFPS-QGNVLDDNTASISLLKSL 263
Cdd:COG3393   22 YTHPEYRGRGLASALVAALAREALARGARTpFLYVDADNPAARRLYERL 70
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
216-263 8.36e-05

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 42.29  E-value: 8.36e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 222831633 216 YTLPEHRRKGY-SRLVAlTLARKLQSRGFPS-QGNVLDDNTASISLLKSL 263
Cdd:COG1247   87 YVDPDARGRGIgRALLE-ALIERARARGYRRlVAVVLADNEASIALYEKL 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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