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Conserved domains on  [gi|1676318664|ref|NP_001008738|]
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folliculin-interacting protein 1 isoform 2 [Homo sapiens]

Protein Classification

folliculin-interacting protein( domain architecture ID 10630352)

folliculin-interacting protein is a binding partner of the GTPase-activating protein FLCN, and is involved in the cellular response to amino acid availability by regulating the mTORC1 signaling cascade

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FNIP_M pfam14637
Folliculin-interacting protein middle domain; This is the middle domain of ...
 288-520 4.46e-105

Folliculin-interacting protein middle domain; This is the middle domain of folliculin-interacting proteins.


:

Pssm-ID: 434087  Cd Length: 226  Bit Score: 329.23  E-value: 4.46e-105
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676318664  288 ESCGPNPGIVRKKKIAIGVIFSLSkdEDENNKFNEFFFSHFPLFESHMNKLKSAIEQAmkmsrrsadaSQRSLAY-NRIV 366
Cdd:pfam14637    1 ATPSSSPPRRKKAKLALAIIISLS--ESSESEFEQFLFEHFPLLESHMSRLRVAIENA----------SGRKQSFvQRIY 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676318664  367 DALNEFRTTICNLYTMPRIGEPVWLTMMSGTPEKNHLCYRFMKEFTFLMENASKNQ---FLPALITAVLTNHLAWVPTVM 443
Cdd:pfam14637   69 RAWEEFRQWICDLYTAPRLKEPVWLNLVSSPNDKRTLAERFLEELCSLLERYDTKDtnfFLSTLLTAVLTHHLGWVATVA 148

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1676318664  444 PNGQP-PIKIFLEKHSSQSVDMLAKTHPYNPLWAQLGDLYGAIGSPVRLARTVVVGKRQDMVQRLLYFLTYFIRCSEL 520
Cdd:pfam14637  149 PPDSStPSNSFLGKHSSDKLDLLAQTHPYNPLWAQLGDLYGAIGSPVRLAKTIVVGSPQELVAKILYVLSYFIRCSEV 226
FNIP_C pfam14638
Folliculin-interacting protein C-terminus; This is the C-terminus of folliculin-interacting ...
 948-1134 3.85e-98

Folliculin-interacting protein C-terminus; This is the C-terminus of folliculin-interacting proteins. This region is responsible for binding to folliculin.


:

Pssm-ID: 464229  Cd Length: 189  Bit Score: 309.19  E-value: 3.85e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676318664  948 IPFPGSKLIEVSAVQPNIANFGRSLLGGYCSSYVPDFVLQGIGS-DERFRQCLMSDLSHAVQHPVLDEPIAEAVCIIADM 1026
Cdd:pfam14638    1 LPLPKSKSISNSEDMWTVRNFGRSLFAGYCDHYVPDFVLQGTTKpDEKWKEVLSADLSHASQHSVLDEPVAEAVCIVADT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676318664 1027 DKWTVQVASSQRRVTDN-KLGKEVLVSSLVSNLLHSTLQLYKHNLSPNFCVMHLEDRLQELYFKSKMLSEYLRGQMRVHV 1105
Cdd:pfam14638   81 DKWTVQVLSSQTSDLKNnGLGEVVSMSQLVSSMLESFVQLYKLKLSAEFCIMHLEDRLQEIYLKSKMLAEYLRGTTRCHL 160

                          170       180
                   ....*....|....*....|....*....
gi 1676318664 1106 KELGVVLGIESSDLPLLAAVASTHSPYVA 1134
Cdd:pfam14638  161 KELTSALGLDSSDLPLLLAVASTHSPYVA 189
FNIP_N pfam14636
Folliculin-interacting protein N-terminus; This is the N-terminus of folliculin-interacting ...
 41-159 4.19e-35

Folliculin-interacting protein N-terminus; This is the N-terminus of folliculin-interacting proteins.


:

Pssm-ID: 464228  Cd Length: 125  Bit Score: 130.08  E-value: 4.19e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676318664   41 QIRLIVYQD-CERRGRNVLFDSSVKRRNEDISVSKLGSDAQVKVFGKCCQLKPGGDSSSSLDSSVTSSSD-----IKDQC 114
Cdd:pfam14636    1 DVRVIIMQDaLGDRGRTLLFDSHAVAKPPEPAPPLSPSDRPSSPGGRHSQTSSRRGPSSPRKSSLSQGSRplvsqTSETD 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1676318664  115 LKYQGSRCSSDANMLGEMMFGSVAMSYKGSTLKIHQIRSPPQLML 159
Cdd:pfam14636   81 PQYQYREYRDDINTLGECIFGSSAMSYKGTSTKVHILPSDPRSML 125
 
Name Accession Description Interval E-value
FNIP_M pfam14637
Folliculin-interacting protein middle domain; This is the middle domain of ...
 288-520 4.46e-105

Folliculin-interacting protein middle domain; This is the middle domain of folliculin-interacting proteins.


Pssm-ID: 434087  Cd Length: 226  Bit Score: 329.23  E-value: 4.46e-105
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676318664  288 ESCGPNPGIVRKKKIAIGVIFSLSkdEDENNKFNEFFFSHFPLFESHMNKLKSAIEQAmkmsrrsadaSQRSLAY-NRIV 366
Cdd:pfam14637    1 ATPSSSPPRRKKAKLALAIIISLS--ESSESEFEQFLFEHFPLLESHMSRLRVAIENA----------SGRKQSFvQRIY 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676318664  367 DALNEFRTTICNLYTMPRIGEPVWLTMMSGTPEKNHLCYRFMKEFTFLMENASKNQ---FLPALITAVLTNHLAWVPTVM 443
Cdd:pfam14637   69 RAWEEFRQWICDLYTAPRLKEPVWLNLVSSPNDKRTLAERFLEELCSLLERYDTKDtnfFLSTLLTAVLTHHLGWVATVA 148

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1676318664  444 PNGQP-PIKIFLEKHSSQSVDMLAKTHPYNPLWAQLGDLYGAIGSPVRLARTVVVGKRQDMVQRLLYFLTYFIRCSEL 520
Cdd:pfam14637  149 PPDSStPSNSFLGKHSSDKLDLLAQTHPYNPLWAQLGDLYGAIGSPVRLAKTIVVGSPQELVAKILYVLSYFIRCSEV 226
FNIP_C pfam14638
Folliculin-interacting protein C-terminus; This is the C-terminus of folliculin-interacting ...
 948-1134 3.85e-98

Folliculin-interacting protein C-terminus; This is the C-terminus of folliculin-interacting proteins. This region is responsible for binding to folliculin.


Pssm-ID: 464229  Cd Length: 189  Bit Score: 309.19  E-value: 3.85e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676318664  948 IPFPGSKLIEVSAVQPNIANFGRSLLGGYCSSYVPDFVLQGIGS-DERFRQCLMSDLSHAVQHPVLDEPIAEAVCIIADM 1026
Cdd:pfam14638    1 LPLPKSKSISNSEDMWTVRNFGRSLFAGYCDHYVPDFVLQGTTKpDEKWKEVLSADLSHASQHSVLDEPVAEAVCIVADT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676318664 1027 DKWTVQVASSQRRVTDN-KLGKEVLVSSLVSNLLHSTLQLYKHNLSPNFCVMHLEDRLQELYFKSKMLSEYLRGQMRVHV 1105
Cdd:pfam14638   81 DKWTVQVLSSQTSDLKNnGLGEVVSMSQLVSSMLESFVQLYKLKLSAEFCIMHLEDRLQEIYLKSKMLAEYLRGTTRCHL 160

                          170       180
                   ....*....|....*....|....*....
gi 1676318664 1106 KELGVVLGIESSDLPLLAAVASTHSPYVA 1134
Cdd:pfam14638  161 KELTSALGLDSSDLPLLLAVASTHSPYVA 189
FNIP_N pfam14636
Folliculin-interacting protein N-terminus; This is the N-terminus of folliculin-interacting ...
 41-159 4.19e-35

Folliculin-interacting protein N-terminus; This is the N-terminus of folliculin-interacting proteins.


Pssm-ID: 464228  Cd Length: 125  Bit Score: 130.08  E-value: 4.19e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676318664   41 QIRLIVYQD-CERRGRNVLFDSSVKRRNEDISVSKLGSDAQVKVFGKCCQLKPGGDSSSSLDSSVTSSSD-----IKDQC 114
Cdd:pfam14636    1 DVRVIIMQDaLGDRGRTLLFDSHAVAKPPEPAPPLSPSDRPSSPGGRHSQTSSRRGPSSPRKSSLSQGSRplvsqTSETD 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1676318664  115 LKYQGSRCSSDANMLGEMMFGSVAMSYKGSTLKIHQIRSPPQLML 159
Cdd:pfam14636   81 PQYQYREYRDDINTLGECIFGSSAMSYKGTSTKVHILPSDPRSML 125
 
Name Accession Description Interval E-value
FNIP_M pfam14637
Folliculin-interacting protein middle domain; This is the middle domain of ...
 288-520 4.46e-105

Folliculin-interacting protein middle domain; This is the middle domain of folliculin-interacting proteins.


Pssm-ID: 434087  Cd Length: 226  Bit Score: 329.23  E-value: 4.46e-105
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676318664  288 ESCGPNPGIVRKKKIAIGVIFSLSkdEDENNKFNEFFFSHFPLFESHMNKLKSAIEQAmkmsrrsadaSQRSLAY-NRIV 366
Cdd:pfam14637    1 ATPSSSPPRRKKAKLALAIIISLS--ESSESEFEQFLFEHFPLLESHMSRLRVAIENA----------SGRKQSFvQRIY 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676318664  367 DALNEFRTTICNLYTMPRIGEPVWLTMMSGTPEKNHLCYRFMKEFTFLMENASKNQ---FLPALITAVLTNHLAWVPTVM 443
Cdd:pfam14637   69 RAWEEFRQWICDLYTAPRLKEPVWLNLVSSPNDKRTLAERFLEELCSLLERYDTKDtnfFLSTLLTAVLTHHLGWVATVA 148

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1676318664  444 PNGQP-PIKIFLEKHSSQSVDMLAKTHPYNPLWAQLGDLYGAIGSPVRLARTVVVGKRQDMVQRLLYFLTYFIRCSEL 520
Cdd:pfam14637  149 PPDSStPSNSFLGKHSSDKLDLLAQTHPYNPLWAQLGDLYGAIGSPVRLAKTIVVGSPQELVAKILYVLSYFIRCSEV 226
FNIP_C pfam14638
Folliculin-interacting protein C-terminus; This is the C-terminus of folliculin-interacting ...
 948-1134 3.85e-98

Folliculin-interacting protein C-terminus; This is the C-terminus of folliculin-interacting proteins. This region is responsible for binding to folliculin.


Pssm-ID: 464229  Cd Length: 189  Bit Score: 309.19  E-value: 3.85e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676318664  948 IPFPGSKLIEVSAVQPNIANFGRSLLGGYCSSYVPDFVLQGIGS-DERFRQCLMSDLSHAVQHPVLDEPIAEAVCIIADM 1026
Cdd:pfam14638    1 LPLPKSKSISNSEDMWTVRNFGRSLFAGYCDHYVPDFVLQGTTKpDEKWKEVLSADLSHASQHSVLDEPVAEAVCIVADT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676318664 1027 DKWTVQVASSQRRVTDN-KLGKEVLVSSLVSNLLHSTLQLYKHNLSPNFCVMHLEDRLQELYFKSKMLSEYLRGQMRVHV 1105
Cdd:pfam14638   81 DKWTVQVLSSQTSDLKNnGLGEVVSMSQLVSSMLESFVQLYKLKLSAEFCIMHLEDRLQEIYLKSKMLAEYLRGTTRCHL 160

                          170       180
                   ....*....|....*....|....*....
gi 1676318664 1106 KELGVVLGIESSDLPLLAAVASTHSPYVA 1134
Cdd:pfam14638  161 KELTSALGLDSSDLPLLLAVASTHSPYVA 189
FNIP_N pfam14636
Folliculin-interacting protein N-terminus; This is the N-terminus of folliculin-interacting ...
 41-159 4.19e-35

Folliculin-interacting protein N-terminus; This is the N-terminus of folliculin-interacting proteins.


Pssm-ID: 464228  Cd Length: 125  Bit Score: 130.08  E-value: 4.19e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676318664   41 QIRLIVYQD-CERRGRNVLFDSSVKRRNEDISVSKLGSDAQVKVFGKCCQLKPGGDSSSSLDSSVTSSSD-----IKDQC 114
Cdd:pfam14636    1 DVRVIIMQDaLGDRGRTLLFDSHAVAKPPEPAPPLSPSDRPSSPGGRHSQTSSRRGPSSPRKSSLSQGSRplvsqTSETD 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1676318664  115 LKYQGSRCSSDANMLGEMMFGSVAMSYKGSTLKIHQIRSPPQLML 159
Cdd:pfam14636   81 PQYQYREYRDDINTLGECIFGSSAMSYKGTSTKVHILPSDPRSML 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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