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Conserved domains on  [gi|56605790|ref|NP_001008358|]
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host cell factor 2 [Rattus norvegicus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 13286889)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
14-332 3.78e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 88.29  E-value: 3.78e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790  14 SFTGPVPRARHGHRAVAIRELMIIFGGGNEG-IADELHVYNTVTNQWflpaVRGDIPPGCAAHGFVC--DGTRILVFGGM 90
Cdd:COG3055   4 SSLPDLPTPRSEAAAALLDGKVYVAGGLSGGsASNSFEVYDPATNTW----SELAPLPGPPRHHAAAvaQDGKLYVFGGF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790  91 VEY---GRYSNELYELQASRWLWKKVkpqpppsGLPPCPRLGHSFSLYGNKCYLFAGlanesedsnNNVPRYLNDFYELE 167
Cdd:COG3055  80 TGAnpsSTPLNDVYVYDPATNTWTKL-------APMPTPRGGATALLLDGKIYVVGG---------WDDGGNVAWVEVYD 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790 168 LQHGSgvvgWSvpaTKGTVPSPRESHTAVIyckrdSGSPKMYVFGGMCGARLDDLWqldletmswskpETKGTVPLPRSL 247
Cdd:COG3055 144 PATGT----WT---QLAPLPTPRDHLAAAV-----LPDGKILVIGGRNGSGFSNTW------------TTLAPLPTARAG 199

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790 248 HTASVIGNKMYIFGGwvphkgentENSPHDCEWRctssfsyLNLDTAEWTTLvsdsqedkkNSRPRPRAGHCAVAIGTRL 327
Cdd:COG3055 200 HAAAVLGGKILVFGG---------ESGFSDEVEA-------YDPATNTWTAL---------GELPTPRHGHAAVLTDGKV 254


                ....*
gi 56605790 328 YFWSG 332
Cdd:COG3055 255 YVIGG 259
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 549-603 6.56e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.18  E-value: 6.56e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 56605790 549 PKGKQSMSKVGNADVPDYSLlKKQDLVPGTVYKFRVAAINGCGIGPFSKLSEFKT 603
Cdd:cd00063  40 EKGSGDWKEVEVTPGSETSY-TLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 609-709 7.38e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.10  E-value: 7.38e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790 609 PGAPSTVRISKNVEG-IHLSWEPPTSPSGNILEYSaylaIRTAQVQDNPSQLVfmRIYCGLKTSCIVTagQLaNAHIDYT 687
Cdd:cd00063   1 PSPPTNLRVTDVTSTsVTLSWTPPEDDGGPITGYV----VEYREKGSGDWKEV--EVTPGSETSYTLT--GL-KPGTEYE 71

                        90       100
                ....*....|....*....|..
gi 56605790 688 srpaivFRISAKNEKGYGPATQ 709
Cdd:cd00063  72 ------FRVRAVNGGGESPPSE 87
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 312-355 1.18e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


:

Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 37.16  E-value: 1.18e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 56605790   312 PRPRAGHCAVAIGTRLYFWSGRDGYkkalNSQVcCKDLWYLDTE 355
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGG----EGQP-SDDVYVLSLP 39
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
14-332 3.78e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 88.29  E-value: 3.78e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790  14 SFTGPVPRARHGHRAVAIRELMIIFGGGNEG-IADELHVYNTVTNQWflpaVRGDIPPGCAAHGFVC--DGTRILVFGGM 90
Cdd:COG3055   4 SSLPDLPTPRSEAAAALLDGKVYVAGGLSGGsASNSFEVYDPATNTW----SELAPLPGPPRHHAAAvaQDGKLYVFGGF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790  91 VEY---GRYSNELYELQASRWLWKKVkpqpppsGLPPCPRLGHSFSLYGNKCYLFAGlanesedsnNNVPRYLNDFYELE 167
Cdd:COG3055  80 TGAnpsSTPLNDVYVYDPATNTWTKL-------APMPTPRGGATALLLDGKIYVVGG---------WDDGGNVAWVEVYD 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790 168 LQHGSgvvgWSvpaTKGTVPSPRESHTAVIyckrdSGSPKMYVFGGMCGARLDDLWqldletmswskpETKGTVPLPRSL 247
Cdd:COG3055 144 PATGT----WT---QLAPLPTPRDHLAAAV-----LPDGKILVIGGRNGSGFSNTW------------TTLAPLPTARAG 199

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790 248 HTASVIGNKMYIFGGwvphkgentENSPHDCEWRctssfsyLNLDTAEWTTLvsdsqedkkNSRPRPRAGHCAVAIGTRL 327
Cdd:COG3055 200 HAAAVLGGKILVFGG---------ESGFSDEVEA-------YDPATNTWTAL---------GELPTPRHGHAAVLTDGKV 254


                ....*
gi 56605790 328 YFWSG 332
Cdd:COG3055 255 YVIGG 259
PLN02193 PLN02193
nitrile-specifier protein
 2-262 4.82e-11

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 65.75  E-value: 4.82e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790    2 AAPSLL-NWRRV-SSFTGPVPRARHGHRAVAIRelMIIFGGG---NEGIADELHVYNTVTNQWFLPAVRGDIPP-GCAAH 75
Cdd:PLN02193 145 STPKLLgKWIKVeQKGEGPGLRCSHGIAQVGNK--IYSFGGEftpNQPIDKHLYVFDLETRTWSISPATGDVPHlSCLGV 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790   76 GFVCDGTRILVFGGMvEYGRYSNELYELQASRWLWKKVkpqpPPSGLPPCPRLGHSFSLYGNKCYLFAGLANESE----D 151
Cdd:PLN02193 223 RMVSIGSTLYVFGGR-DASRQYNGFYSFDTTTNEWKLL----TPVEEGPTPRSFHSMAADEENVYVFGGVSATARlktlD 297

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790  152 SNNNVPRylndfyelelqhgsgvvGWSVPATkgtvpsPRESHTAVIYCKRDSGSPKMYVFGGMCGARLDDLWQLDLETMS 231
Cdd:PLN02193 298 SYNIVDK-----------------KWFHCST------PGDSFSIRGGAGLEVVQGKVWVVYGFNGCEVDDVHYYDPVQDK 354

                        250       260       270
                 ....*....|....*....|....*....|.
gi 56605790  232 WSKPETKGTVPLPRSLHTASVIGNKMYIFGG 262
Cdd:PLN02193 355 WTQVETFGVRPSERSVFASAAVGKHIVIFGG 385
Kelch_3 pfam13415
Galactose oxidase, central domain;
207-253 1.38e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 45.74  E-value: 1.38e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 56605790   207 KMYVFGGMC---GARLDDLWQLDLETMSWSKPetkGTVPLPRSLHTASVI 253
Cdd:pfam13415   3 KLYIFGGLGfdgQTRLNDLYVYDLDTNTWTQI---GDLPPPRSGHSATYI 49
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 549-603 6.56e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.18  E-value: 6.56e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 56605790 549 PKGKQSMSKVGNADVPDYSLlKKQDLVPGTVYKFRVAAINGCGIGPFSKLSEFKT 603
Cdd:cd00063  40 EKGSGDWKEVEVTPGSETSY-TLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 609-709 7.38e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.10  E-value: 7.38e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790 609 PGAPSTVRISKNVEG-IHLSWEPPTSPSGNILEYSaylaIRTAQVQDNPSQLVfmRIYCGLKTSCIVTagQLaNAHIDYT 687
Cdd:cd00063   1 PSPPTNLRVTDVTSTsVTLSWTPPEDDGGPITGYV----VEYREKGSGDWKEV--EVTPGSETSYTLT--GL-KPGTEYE 71

                        90       100
                ....*....|....*....|..
gi 56605790 688 srpaivFRISAKNEKGYGPATQ 709
Cdd:cd00063  72 ------FRVRAVNGGGESPPSE 87
fn3 pfam00041
Fibronectin type III domain;
572-596 2.94e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.09  E-value: 2.94e-04
                          10        20
                  ....*....|....*....|....*
gi 56605790   572 QDLVPGTVYKFRVAAINGCGIGPFS 596
Cdd:pfam00041  61 TGLKPGTEYEVRVQAVNGGGEGPPS 85
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 312-355 1.18e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 37.16  E-value: 1.18e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 56605790   312 PRPRAGHCAVAIGTRLYFWSGRDGYkkalNSQVcCKDLWYLDTE 355
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGG----EGQP-SDDVYVLSLP 39
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 609-705 5.18e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 36.44  E-value: 5.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790    609 PGAPSTVRISKNVEG-IHLSWEPPTSPSGN--ILEYsaylairtaQVQDNPSQLVFMRIYC-GLKTSCIVTagQLaNAHI 684
Cdd:smart00060   1 PSPPSNLRVTDVTSTsVTLSWEPPPDDGITgyIVGY---------RVEYREEGSEWKEVNVtPSSTSYTLT--GL-KPGT 68

                           90       100
                   ....*....|....*....|.
gi 56605790    685 DYTsrpaivFRISAKNEKGYG 705
Cdd:smart00060  69 EYE------FRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
610-708 5.38e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 36.62  E-value: 5.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790   610 GAPSTVRIS-KNVEGIHLSWEPPTSPSGNILEYSaylaIRTAQVQDNPSQLVFMRiyCGLKTSCIVTagQLaNAHIDYTs 688
Cdd:pfam00041   1 SAPSNLTVTdVTSTSLTVSWTPPPDGNGPITGYE----VEYRPKNSGEPWNEITV--PGTTTSVTLT--GL-KPGTEYE- 70

                          90       100
                  ....*....|....*....|
gi 56605790   689 rpaivFRISAKNEKGYGPAT 708
Cdd:pfam00041  71 -----VRVQAVNGGGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
556-635 7.04e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 39.60  E-value: 7.04e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790 556 SKVGNADVPDYSLLKKQDLVPGTVYKFRVAAINGCGIGPFSKLSEFKTcIPGFPGAPSTVRISKNVEG-IHLSWEPPTSP 634
Cdd:COG3401 181 ATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTT-PTTPPSAPTGLTATADTPGsVTLSWDPVTES 259


                .
gi 56605790 635 S 635
Cdd:COG3401 260 D 260
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
14-332 3.78e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 88.29  E-value: 3.78e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790  14 SFTGPVPRARHGHRAVAIRELMIIFGGGNEG-IADELHVYNTVTNQWflpaVRGDIPPGCAAHGFVC--DGTRILVFGGM 90
Cdd:COG3055   4 SSLPDLPTPRSEAAAALLDGKVYVAGGLSGGsASNSFEVYDPATNTW----SELAPLPGPPRHHAAAvaQDGKLYVFGGF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790  91 VEY---GRYSNELYELQASRWLWKKVkpqpppsGLPPCPRLGHSFSLYGNKCYLFAGlanesedsnNNVPRYLNDFYELE 167
Cdd:COG3055  80 TGAnpsSTPLNDVYVYDPATNTWTKL-------APMPTPRGGATALLLDGKIYVVGG---------WDDGGNVAWVEVYD 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790 168 LQHGSgvvgWSvpaTKGTVPSPRESHTAVIyckrdSGSPKMYVFGGMCGARLDDLWqldletmswskpETKGTVPLPRSL 247
Cdd:COG3055 144 PATGT----WT---QLAPLPTPRDHLAAAV-----LPDGKILVIGGRNGSGFSNTW------------TTLAPLPTARAG 199

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790 248 HTASVIGNKMYIFGGwvphkgentENSPHDCEWRctssfsyLNLDTAEWTTLvsdsqedkkNSRPRPRAGHCAVAIGTRL 327
Cdd:COG3055 200 HAAAVLGGKILVFGG---------ESGFSDEVEA-------YDPATNTWTAL---------GELPTPRHGHAAVLTDGKV 254


                ....*
gi 56605790 328 YFWSG 332
Cdd:COG3055 255 YVIGG 259
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
9-264 2.41e-17

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 82.90  E-value: 2.41e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790   9 WRRVSSFTGPvprARHGHRAVAIRELMIIFGG-----GNEGIADELHVYNTVTNQWFlpaVRGDIPPGCAAHGFVCDGTR 83
Cdd:COG3055  50 WSELAPLPGP---PRHHAAAVAQDGKLYVFGGftganPSSTPLNDVYVYDPATNTWT---KLAPMPTPRGGATALLLDGK 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790  84 ILVFGGMVEYGRYSN-ELYELQASRWlwKKVKPQPPPsglppcpRLGHS-FSLYGNKCYLFAGlANESEDSNNnvpryln 161
Cdd:COG3055 124 IYVVGGWDDGGNVAWvEVYDPATGTW--TQLAPLPTP-------RDHLAaAVLPDGKILVIGG-RNGSGFSNT------- 186

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790 162 dfyelelqhgsgvvgWSvpaTKGTVPSPRESHTAVIYckrdsgSPKMYVFGGMCGArLDDLWQLDLETMSWSkpeTKGTV 241
Cdd:COG3055 187 ---------------WT---TLAPLPTARAGHAAAVL------GGKILVFGGESGF-SDEVEAYDPATNTWT---ALGEL 238

                       250       260
                ....*....|....*....|...
gi 56605790 242 PLPRSLHTASVIGNKMYIFGGWV 264
Cdd:COG3055 239 PTPRHGHAAVLTDGKVYVIGGET 261
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
134-335 1.13e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 77.89  E-value: 1.13e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790 134 LYGNKCYLFAGLANESedsnnnvprYLNDFYELELQHGSgvvgWSvpaTKGTVPSPRESHTAVIYckrDSGspKMYVFGG 213
Cdd:COG3055  20 LLDGKVYVAGGLSGGS---------ASNSFEVYDPATNT----WS---ELAPLPGPPRHHAAAVA---QDG--KLYVFGG 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790 214 MCGAR-----LDDLWQLDLETMSWSKpetKGTVPLPRSLHTASVIGNKMYIFGGWVPHKGentensphdcewrcTSSFSY 288
Cdd:COG3055  79 FTGANpsstpLNDVYVYDPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWDDGGN--------------VAWVEV 141

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 56605790 289 LNLDTAEWTTLVSDsqedkknsrPRPRAGHCA-VAIGTRLYFWSGRDG 335
Cdd:COG3055 142 YDPATGTWTQLAPL---------PTPRDHLAAaVLPDGKILVIGGRNG 180
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
66-336 1.52e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 77.50  E-value: 1.52e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790  66 GDIP-PGCAAHGFVCDGtRILVFGGMvEYGRYSN--ELYELQASRWlwkkvkpqpPPSGLPPCPRLGHSFS-LYGNKCYL 141
Cdd:COG3055   7 PDLPtPRSEAAAALLDG-KVYVAGGL-SGGSASNsfEVYDPATNTW---------SELAPLPGPPRHHAAAvAQDGKLYV 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790 142 FAGLaneseDSNNNVPRYLNDFYELELQHGSgvvgWSvpaTKGTVPSPRESHTAVIYckrdsgSPKMYVFGGMCGA-RLD 220
Cdd:COG3055  76 FGGF-----TGANPSSTPLNDVYVYDPATNT----WT---KLAPMPTPRGGATALLL------DGKIYVVGGWDDGgNVA 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790 221 DLWQLDLETMSWSkpeTKGTVPLPRSLHTASVIGN-KMYIFGGwvphkgentensphdcewrcTSSFSYLNldtaEWTTL 299
Cdd:COG3055 138 WVEVYDPATGTWT---QLAPLPTPRDHLAAAVLPDgKILVIGG--------------------RNGSGFSN----TWTTL 190

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 56605790 300 vsdsqedkkNSRPRPRAGHCAVAIGTRLYFWSGRDGY 336
Cdd:COG3055 191 ---------APLPTARAGHAAAVLGGKILVFGGESGF 218
PLN02193 PLN02193
nitrile-specifier protein
 2-262 4.82e-11

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 65.75  E-value: 4.82e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790    2 AAPSLL-NWRRV-SSFTGPVPRARHGHRAVAIRelMIIFGGG---NEGIADELHVYNTVTNQWFLPAVRGDIPP-GCAAH 75
Cdd:PLN02193 145 STPKLLgKWIKVeQKGEGPGLRCSHGIAQVGNK--IYSFGGEftpNQPIDKHLYVFDLETRTWSISPATGDVPHlSCLGV 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790   76 GFVCDGTRILVFGGMvEYGRYSNELYELQASRWLWKKVkpqpPPSGLPPCPRLGHSFSLYGNKCYLFAGLANESE----D 151
Cdd:PLN02193 223 RMVSIGSTLYVFGGR-DASRQYNGFYSFDTTTNEWKLL----TPVEEGPTPRSFHSMAADEENVYVFGGVSATARlktlD 297

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790  152 SNNNVPRylndfyelelqhgsgvvGWSVPATkgtvpsPRESHTAVIYCKRDSGSPKMYVFGGMCGARLDDLWQLDLETMS 231
Cdd:PLN02193 298 SYNIVDK-----------------KWFHCST------PGDSFSIRGGAGLEVVQGKVWVVYGFNGCEVDDVHYYDPVQDK 354

                        250       260       270
                 ....*....|....*....|....*....|.
gi 56605790  232 WSKPETKGTVPLPRSLHTASVIGNKMYIFGG 262
Cdd:PLN02193 355 WTQVETFGVRPSERSVFASAAVGKHIVIFGG 385
PLN02153 PLN02153
epithiospecifier protein
 16-264 2.27e-09

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 59.61  E-value: 2.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790   16 TGPVPRARHGHRAVAirELMIIFGGG---NEGIADELHVYNTVTNQWFLPAVRGDIPP-GCAAHGFVCDGTRILVFGGMV 91
Cdd:PLN02153  18 KGPGPRCSHGIAVVG--DKLYSFGGElkpNEHIDKDLYVFDFNTHTWSIAPANGDVPRiSCLGVRMVAVGTKLYIFGGRD 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790   92 EYGRYSN-ELYELQASRWLWkkvkPQPPPSGLPPCPRLGHSFSLYGNKCYLFAGLaneSEDSNNNVPRYLNDFYELELQH 170
Cdd:PLN02153  96 EKREFSDfYSYDTVKNEWTF----LTKLDEEGGPEARTFHSMASDENHVYVFGGV---SKGGLMKTPERFRTIEAYNIAD 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790  171 GsgvvGWSvpatkgTVPSPRESHTA--------------VIYCKRDSGSPkmyvfGGMCGARLDDLWQLDLETMSWSKPE 236
Cdd:PLN02153 169 G----KWV------QLPDPGENFEKrggagfavvqgkiwVVYGFATSILP-----GGKSDYESNAVQFFDPASGKWTEVE 233

                        250       260
                 ....*....|....*....|....*...
gi 56605790  237 TKGTVPLPRSLHTASVIGNKMYIFGGWV 264
Cdd:PLN02153 234 TTGAKPSARSVFAHAVVGKYIIIFGGEV 261
PLN02153 PLN02153
epithiospecifier protein
 17-268 4.83e-08

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 55.38  E-value: 4.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790   17 GPVPR-ARHGHRAVAIRELMIIFGGGNEGIA-DELHVYNTVTNQW-FLPAVrgDIPPGCAA---HGFVCDGTRILVFGGM 90
Cdd:PLN02153  69 GDVPRiSCLGVRMVAVGTKLYIFGGRDEKREfSDFYSYDTVKNEWtFLTKL--DEEGGPEArtfHSMASDENHVYVFGGV 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790   91 VEYG------RYSN-ELYELQASRWLwkkvkpQPPPSGLPPCPRLGHSFSLYGNKCYLFAGLANESedsnnnVPRYLNDF 163
Cdd:PLN02153 147 SKGGlmktpeRFRTiEAYNIADGKWV------QLPDPGENFEKRGGAGFAVVQGKIWVVYGFATSI------LPGGKSDY 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790  164 YELELQHGSGVVG-WSVPATKGTVPSPRE--SHTAViyckrdsgSPKMYVFGGMC----------GARLDDLWQLDLETM 230
Cdd:PLN02153 215 ESNAVQFFDPASGkWTEVETTGAKPSARSvfAHAVV--------GKYIIIFGGEVwpdlkghlgpGTLSNEGYALDTETL 286

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 56605790  231 SWSKPETKGTVPLPR---SLHTASVIG-NKMYIFGGWVPHKG 268
Cdd:PLN02153 287 VWEKLGECGEPAMPRgwtAYTTATVYGkNGLLMHGGKLPTNE 328
PLN02193 PLN02193
nitrile-specifier protein
 232-375 5.92e-07

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 52.65  E-value: 5.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790  232 WSKPETKGTVPLPRSLHTASVIGNKMYIFGgwvphkGENTENSPHDcewrctSSFSYLNLDTAEWTtlVSDSQEDKKNSR 311
Cdd:PLN02193 153 WIKVEQKGEGPGLRCSHGIAQVGNKIYSFG------GEFTPNQPID------KHLYVFDLETRTWS--ISPATGDVPHLS 218

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 56605790  312 PrprAGHCAVAIGTRLYFWSGRDGYKK--ALNSQVCCKDLWYLDT--EKPPAPSQVQLIKATTNSFHV 375
Cdd:PLN02193 219 C---LGVRMVSIGSTLYVFGGRDASRQynGFYSFDTTTNEWKLLTpvEEGPTPRSFHSMAADEENVYV 283
Kelch_3 pfam13415
Galactose oxidase, central domain;
207-253 1.38e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 45.74  E-value: 1.38e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 56605790   207 KMYVFGGMC---GARLDDLWQLDLETMSWSKPetkGTVPLPRSLHTASVI 253
Cdd:pfam13415   3 KLYIFGGLGfdgQTRLNDLYVYDLDTNTWTQI---GDLPPPRSGHSATYI 49
PLN02193 PLN02193
nitrile-specifier protein
 77-262 2.15e-06

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 50.72  E-value: 2.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790   77 FVCDGTRILVFggmveYGRYSNELYELQASRWL---------WKKVKPQPPPSGLppcpRLGHSFSLYGNKCYLFAGlan 147
Cdd:PLN02193 116 FVLQGGKIVGF-----HGRSTDVLHSLGAYISLpstpkllgkWIKVEQKGEGPGL----RCSHGIAQVGNKIYSFGG--- 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790  148 eSEDSNNNVPRYLNDFyELELQhgsgvvGWSVPATKGTVPspresHTAVIYCKRDSGSPKMYVFGGMCGAR-LDDLWQLD 226
Cdd:PLN02193 184 -EFTPNQPIDKHLYVF-DLETR------TWSISPATGDVP-----HLSCLGVRMVSIGSTLYVFGGRDASRqYNGFYSFD 250

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 56605790  227 LETMSWS--KPETKGtvPLPRSLHTASVIGNKMYIFGG 262
Cdd:PLN02193 251 TTTNEWKllTPVEEG--PTPRSFHSMAADEENVYVFGG 286
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 549-603 6.56e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.18  E-value: 6.56e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 56605790 549 PKGKQSMSKVGNADVPDYSLlKKQDLVPGTVYKFRVAAINGCGIGPFSKLSEFKT 603
Cdd:cd00063  40 EKGSGDWKEVEVTPGSETSY-TLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
8-104 1.18e-05

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 47.84  E-value: 1.18e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790   8 NWRRVSSFtgPVPRARHGHRAVAIRelmIIFGGGNEGIADELHVYNTVTNQWFlpaVRGDIPPGCAAHGFVCDGTRILVF 87
Cdd:COG3055 186 TWTTLAPL--PTARAGHAAAVLGGK---ILVFGGESGFSDEVEAYDPATNTWT---ALGELPTPRHGHAAVLTDGKVYVI 257

                        90
                ....*....|....*..
gi 56605790  88 GGMVEYGRYSNELYELQ 104
Cdd:COG3055 258 GGETKPGVRTPLVTSAE 274
PRK14131 PRK14131
N-acetylneuraminate epimerase;
9-89 1.56e-05

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 47.70  E-value: 1.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790    9 WRRVSSFTGPvprARHGHRAVAIRELMIIFGG----GNEG---IADELHVYNTVTNQWFLPAVRGdiPPGCAAH-GFVCD 80
Cdd:PRK14131  64 WTKIAAFPGG---PREQAVAAFIDGKLYVFGGigktNSEGspqVFDDVYKYDPKTNSWQKLDTRS--PVGLAGHvAVSLH 138


                 ....*....
gi 56605790   81 GTRILVFGG 89
Cdd:PRK14131 139 NGKAYITGG 147
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 609-709 7.38e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.10  E-value: 7.38e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790 609 PGAPSTVRISKNVEG-IHLSWEPPTSPSGNILEYSaylaIRTAQVQDNPSQLVfmRIYCGLKTSCIVTagQLaNAHIDYT 687
Cdd:cd00063   1 PSPPTNLRVTDVTSTsVTLSWTPPEDDGGPITGYV----VEYREKGSGDWKEV--EVTPGSETSYTLT--GL-KPGTEYE 71

                        90       100
                ....*....|....*....|..
gi 56605790 688 srpaivFRISAKNEKGYGPATQ 709
Cdd:cd00063  72 ------FRVRAVNGGGESPPSE 87
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
573-634 8.95e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 45.76  E-value: 8.95e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 56605790 573 DLVPGTVYKFRVAAINGCGI-GPFSKLSEFKTCIPGfPGAPSTVRISKNVE-GIHLSWEPPTSP 634
Cdd:COG3401 291 GLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTP-PAAPSGLTATAVGSsSITLSWTASSDA 353
fn3 pfam00041
Fibronectin type III domain;
572-596 2.94e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.09  E-value: 2.94e-04
                          10        20
                  ....*....|....*....|....*
gi 56605790   572 QDLVPGTVYKFRVAAINGCGIGPFS 596
Cdd:pfam00041  61 TGLKPGTEYEVRVQAVNGGGEGPPS 85
Kelch_3 pfam13415
Galactose oxidase, central domain;
254-323 3.46e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 38.81  E-value: 3.46e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790   254 GNKMYIFGGWVPHKGEntensphdcewrCTSSFSYLNLDTAEWTTLvsdsqedkkNSRPRPRAGHCAVAI 323
Cdd:pfam13415   1 GDKLYIFGGLGFDGQT------------RLNDLYVYDLDTNTWTQI---------GDLPPPRSGHSATYI 49
PLN02153 PLN02153
epithiospecifier protein
 232-334 5.73e-04

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 42.67  E-value: 5.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790  232 WSKPETKG-TVPLPRSLHTASVIGNKMYIFGGwvphkgENTENSPHDcewrctSSFSYLNLDTAEWttlvsdSQEDKKNS 310
Cdd:PLN02153   9 WIKVEQKGgKGPGPRCSHGIAVVGDKLYSFGG------ELKPNEHID------KDLYVFDFNTHTW------SIAPANGD 70

                         90       100
                 ....*....|....*....|....*
gi 56605790  311 RPRPRA-GHCAVAIGTRLYFWSGRD 334
Cdd:PLN02153  71 VPRISClGVRMVAVGTKLYIFGGRD 95
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 244-301 6.13e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.98  E-value: 6.13e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 56605790   244 PRSLHTASVIGNKMYIFGGWvphkgentensphdCEWRCTSSFSYLNLDTAEWTTLVS 301
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGF--------------DGNQSLNSVEVYDPETNTWSKLPS 44
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 312-355 1.18e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 37.16  E-value: 1.18e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 56605790   312 PRPRAGHCAVAIGTRLYFWSGRDGYkkalNSQVcCKDLWYLDTE 355
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGG----EGQP-SDDVYVLSLP 39
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
231-337 1.18e-03

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 41.29  E-value: 1.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790 231 SWSkpeTKGTVPLPRSLHTASVIGNKMYIFGGWVphkgentensphdcEWRCTSSFSYLNLDTAEWTTLVSDSQEdkkns 310
Cdd:COG3055   2 TWS---SLPDLPTPRSEAAAALLDGKVYVAGGLS--------------GGSASNSFEVYDPATNTWSELAPLPGP----- 59

                        90       100
                ....*....|....*....|....*..
gi 56605790 311 rprPRAGHCAVAIGTRLYFWSGRDGYK 337
Cdd:COG3055  60 ---PRHHAAAVAQDGKLYVFGGFTGAN 83
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 187-229 1.62e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 36.77  E-value: 1.62e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 56605790   187 PSPRESHTAVIYckrdsgSPKMYVFGGMCGAR---LDDLWQLDLET 229
Cdd:pfam13854   1 PVPRYGHCAVTV------GDYIYLYGGYTGGEgqpSDDVYVLSLPT 40
Kelch_4 pfam13418
Galactose oxidase, central domain;
189-234 2.49e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 36.44  E-value: 2.49e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 56605790   189 PRESHTAViYCKRDSGspkmYVFGGMC--GARLDDLWQLDLETMSWSK 234
Cdd:pfam13418   1 PRAYHTST-SIPDDTI----YLFGGEGedGTLLSDLWVFDLSTNEWTR 43
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 22-59 4.11e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 35.67  E-value: 4.11e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 56605790    22 ARHGHRAVAIRELMIIFGGGNEGIA-DELHVYNTVTNQW 59
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSlNSVEVYDPETNTW 39
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 609-705 5.18e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 36.44  E-value: 5.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790    609 PGAPSTVRISKNVEG-IHLSWEPPTSPSGN--ILEYsaylairtaQVQDNPSQLVFMRIYC-GLKTSCIVTagQLaNAHI 684
Cdd:smart00060   1 PSPPSNLRVTDVTSTsVTLSWEPPPDDGITgyIVGY---------RVEYREEGSEWKEVNVtPSSTSYTLT--GL-KPGT 68

                           90       100
                   ....*....|....*....|.
gi 56605790    685 DYTsrpaivFRISAKNEKGYG 705
Cdd:smart00060  69 EYE------FRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
610-708 5.38e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 36.62  E-value: 5.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790   610 GAPSTVRIS-KNVEGIHLSWEPPTSPSGNILEYSaylaIRTAQVQDNPSQLVFMRiyCGLKTSCIVTagQLaNAHIDYTs 688
Cdd:pfam00041   1 SAPSNLTVTdVTSTSLTVSWTPPPDGNGPITGYE----VEYRPKNSGEPWNEITV--PGTTTSVTLT--GL-KPGTEYE- 70

                          90       100
                  ....*....|....*....|
gi 56605790   689 rpaivFRISAKNEKGYGPAT 708
Cdd:pfam00041  71 -----VRVQAVNGGGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
556-635 7.04e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 39.60  E-value: 7.04e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605790 556 SKVGNADVPDYSLLKKQDLVPGTVYKFRVAAINGCGIGPFSKLSEFKTcIPGFPGAPSTVRISKNVEG-IHLSWEPPTSP 634
Cdd:COG3401 181 ATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTT-PTTPPSAPTGLTATADTPGsVTLSWDPVTES 259


                .
gi 56605790 635 S 635
Cdd:COG3401 260 D 260
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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