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Conserved domains on  [gi|55953072|ref|NP_001007270|]
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gem-associated protein 7 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Gemin7 cd11677
Gemin 7; Gemins 7, together with the survival motor neuron (SMN) protein, other Gemins, and ...
54-130 2.53e-43

Gemin 7; Gemins 7, together with the survival motor neuron (SMN) protein, other Gemins, and Unr-interacting protein (UNRIP) form the SMN complex, which plays an important role in the Sm core assembly reaction, by binding directly to the Sm proteins, as well as UsnRNAs. Gemin 7 forms a heterodimer with Gemin 6, which serve as a surrogate for the SmB-SmD3 dimer during the formation of the heptameric Sm ring.


:

Pssm-ID: 212488  Cd Length: 77  Bit Score: 136.62  E-value: 2.53e-43
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 55953072  54 QEQRARAALRERYLRSLLAMVGHQVSFTLHEGVRVAAHFGATDLDVANFYVSQLQTPIGVQAEALLRCSDIISYTFK 130
Cdd:cd11677   1 LEQEARAFLRERFLRSLLALAGKPVEFTMHENTTVTATFKACDIDVENFQVSNLKTPLGIQPEALLRTSDIISITFD 77
SUZ-C super family cl15152
SUZ-C motif; The SUZ-C domain is a conserved motif found in one or more copies in several ...
8-25 6.30e-03

SUZ-C motif; The SUZ-C domain is a conserved motif found in one or more copies in several RNA-binding proteins. It is always found at the C-terminus of the protein and appear to be required for localization of the protein to specific subcellular structures. It was first characterized in the C.elegans protein Szy-20 which localizes to the centrosome. It is widely distributed in eukaryotes.


The actual alignment was detected with superfamily member pfam12901:

Pssm-ID: 463745  Cd Length: 33  Bit Score: 32.51  E-value: 6.30e-03
                          10
                  ....*....|....*...
gi 55953072     8 PVPVLRLPRGPDGfSRGF 25
Cdd:pfam12901  14 NNNVLRQPRGPDG-SKGF 30
 
Name Accession Description Interval E-value
Gemin7 cd11677
Gemin 7; Gemins 7, together with the survival motor neuron (SMN) protein, other Gemins, and ...
54-130 2.53e-43

Gemin 7; Gemins 7, together with the survival motor neuron (SMN) protein, other Gemins, and Unr-interacting protein (UNRIP) form the SMN complex, which plays an important role in the Sm core assembly reaction, by binding directly to the Sm proteins, as well as UsnRNAs. Gemin 7 forms a heterodimer with Gemin 6, which serve as a surrogate for the SmB-SmD3 dimer during the formation of the heptameric Sm ring.


Pssm-ID: 212488  Cd Length: 77  Bit Score: 136.62  E-value: 2.53e-43
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 55953072  54 QEQRARAALRERYLRSLLAMVGHQVSFTLHEGVRVAAHFGATDLDVANFYVSQLQTPIGVQAEALLRCSDIISYTFK 130
Cdd:cd11677   1 LEQEARAFLRERFLRSLLALAGKPVEFTMHENTTVTATFKACDIDVENFQVSNLKTPLGIQPEALLRTSDIISITFD 77
Gemin7 pfam11095
Gem-associated protein 7 (Gemin7); Gemin7 is a novel component of the survival of motor neuron ...
54-129 5.02e-40

Gem-associated protein 7 (Gemin7); Gemin7 is a novel component of the survival of motor neuron complex which functions in the assembly of spliceosomal small nuclear ribonucleoproteins. Gemin7 interacts with several Sm proteins of spliceosomal small nuclear ribonucleoproteins, especially SmE.


Pssm-ID: 463219  Cd Length: 76  Bit Score: 128.46  E-value: 5.02e-40
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 55953072    54 QEQRARAALRERYLRSLLAMVGHQVSFTLHEGVRVAAHFGATDLDVANFYVSQLQTPIGVQAEALLRCSDIISYTF 129
Cdd:pfam11095   1 EEQEARAFLRERFLRSLLALVGKPATFTLYENTTVTATFKGSDIDEENFLVSNLQTPLGTIKEALLRCSDIISISF 76
SUZ-C pfam12901
SUZ-C motif; The SUZ-C domain is a conserved motif found in one or more copies in several ...
8-25 6.30e-03

SUZ-C motif; The SUZ-C domain is a conserved motif found in one or more copies in several RNA-binding proteins. It is always found at the C-terminus of the protein and appear to be required for localization of the protein to specific subcellular structures. It was first characterized in the C.elegans protein Szy-20 which localizes to the centrosome. It is widely distributed in eukaryotes.


Pssm-ID: 463745  Cd Length: 33  Bit Score: 32.51  E-value: 6.30e-03
                          10
                  ....*....|....*...
gi 55953072     8 PVPVLRLPRGPDGfSRGF 25
Cdd:pfam12901  14 NNNVLRQPRGPDG-SKGF 30
 
Name Accession Description Interval E-value
Gemin7 cd11677
Gemin 7; Gemins 7, together with the survival motor neuron (SMN) protein, other Gemins, and ...
54-130 2.53e-43

Gemin 7; Gemins 7, together with the survival motor neuron (SMN) protein, other Gemins, and Unr-interacting protein (UNRIP) form the SMN complex, which plays an important role in the Sm core assembly reaction, by binding directly to the Sm proteins, as well as UsnRNAs. Gemin 7 forms a heterodimer with Gemin 6, which serve as a surrogate for the SmB-SmD3 dimer during the formation of the heptameric Sm ring.


Pssm-ID: 212488  Cd Length: 77  Bit Score: 136.62  E-value: 2.53e-43
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 55953072  54 QEQRARAALRERYLRSLLAMVGHQVSFTLHEGVRVAAHFGATDLDVANFYVSQLQTPIGVQAEALLRCSDIISYTFK 130
Cdd:cd11677   1 LEQEARAFLRERFLRSLLALAGKPVEFTMHENTTVTATFKACDIDVENFQVSNLKTPLGIQPEALLRTSDIISITFD 77
Gemin7 pfam11095
Gem-associated protein 7 (Gemin7); Gemin7 is a novel component of the survival of motor neuron ...
54-129 5.02e-40

Gem-associated protein 7 (Gemin7); Gemin7 is a novel component of the survival of motor neuron complex which functions in the assembly of spliceosomal small nuclear ribonucleoproteins. Gemin7 interacts with several Sm proteins of spliceosomal small nuclear ribonucleoproteins, especially SmE.


Pssm-ID: 463219  Cd Length: 76  Bit Score: 128.46  E-value: 5.02e-40
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 55953072    54 QEQRARAALRERYLRSLLAMVGHQVSFTLHEGVRVAAHFGATDLDVANFYVSQLQTPIGVQAEALLRCSDIISYTF 129
Cdd:pfam11095   1 EEQEARAFLRERFLRSLLALVGKPATFTLYENTTVTATFKGSDIDEENFLVSNLQTPLGTIKEALLRCSDIISISF 76
Sm_like cd00600
Sm and related proteins; The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to ...
70-128 9.57e-06

Sm and related proteins; The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of this family share a highly conserved Sm fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel beta-sheet. Sm-like proteins exist in archaea as well as prokaryotes that form heptameric and hexameric ring structures similar to those found in eukaryotes.


Pssm-ID: 212462 [Multi-domain]  Cd Length: 63  Bit Score: 40.69  E-value: 9.57e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 55953072  70 LLAMVGHQVSFTLHEGVRVAAHFGATDlDVANFYVSQLQTP-----IGVQAEALLRCSDIISYT 128
Cdd:cd00600   1 LKDFIGKTVSVELKDGRVLTGTLVAFD-KYMNLVLDDVVETgrdgkVRVLGLVLIRGSNIVSIR 63
SUZ-C pfam12901
SUZ-C motif; The SUZ-C domain is a conserved motif found in one or more copies in several ...
8-25 6.30e-03

SUZ-C motif; The SUZ-C domain is a conserved motif found in one or more copies in several RNA-binding proteins. It is always found at the C-terminus of the protein and appear to be required for localization of the protein to specific subcellular structures. It was first characterized in the C.elegans protein Szy-20 which localizes to the centrosome. It is widely distributed in eukaryotes.


Pssm-ID: 463745  Cd Length: 33  Bit Score: 32.51  E-value: 6.30e-03
                          10
                  ....*....|....*...
gi 55953072     8 PVPVLRLPRGPDGfSRGF 25
Cdd:pfam12901  14 NNNVLRQPRGPDG-SKGF 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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