NCBI Conserved Domain Search

Conserved domains on [gi|53933287|ref|NP_001005517|]

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olfactory receptor 5K4 [Homo sapiens]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

7tm_GPCRs super family

cl28897

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...

25-300

1.86e-147

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

The actual alignment was detected with superfamily member cd15409:

Pssm-ID: 475119 [Multi-domain] Cd Length: 279 Bit Score: 416.04 E-value: 1.86e-147

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFL 104
Cdd:cd15409   1 VPLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 105 CLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPL 184
Cdd:cd15409  81 GFSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 185 YRLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYICLL-MYIGPS- 262
Cdd:cd15409 161 LKISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFfMYVRPSs 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 53933287 263 -EEGDKDTPVAIFYAIVIPLLNPFIYSLRNKEVINVLKK 300
Cdd:cd15409 241 lYALDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279

Name

Accession

Description

Interval

E-value

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

25-300

1.86e-147

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 416.04 E-value: 1.86e-147

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFL 104
Cdd:cd15409   1 VPLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 105 CLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPL 184
Cdd:cd15409  81 GFSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 185 YRLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYICLL-MYIGPS- 262
Cdd:cd15409 161 LKISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFfMYVRPSs 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 53933287 263 -EEGDKDTPVAIFYAIVIPLLNPFIYSLRNKEVINVLKK 300
Cdd:cd15409 241 lYALDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

31-302

3.02e-39

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 139.56 E-value: 3.02e-39

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287    31 FSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLCLAETT 110
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287   111 DCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLYRLSCT 190
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287   191 DPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYICLLMYIGPSEEGDKDTP 270
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPP 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 53933287   271 -----VAIFYAIVIPLLNPFIYSLRNKEVINVLKKIM 302
Cdd:pfam13853 241 llqimMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277

Name

Accession

Description

Interval

E-value

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

25-300

1.86e-147

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 416.04 E-value: 1.86e-147

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFL 104
Cdd:cd15409   1 VPLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 105 CLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPL 184
Cdd:cd15409  81 GFSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 185 YRLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYICLL-MYIGPS- 262
Cdd:cd15409 161 LKISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFfMYVRPSs 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 53933287 263 -EEGDKDTPVAIFYAIVIPLLNPFIYSLRNKEVINVLKK 300
Cdd:cd15409 241 lYALDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

25-291

1.15e-126

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 362.60 E-value: 1.15e-126

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFL 104
Cdd:cd15230   1 VPLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 105 CLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPL 184
Cdd:cd15230  81 AVFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 185 YRLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYICLL-MYIGPSE 263
Cdd:cd15230 161 LKLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIfMYLRPSS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 53933287 264 EG--DKDTPVAIFYAIVIPLLNPFIYSLRN 291
Cdd:cd15230 241 SYslDQDKVVSVFYTVVIPMLNPLIYSLRN 270

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

12-302

1.54e-119

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 345.80 E-value: 1.54e-119

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  12 FILIGFTNYPELKTLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRI 91
Cdd:cd15410   1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  92 ISLYECMAQFYFLCLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRS 171
Cdd:cd15410  81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 172 NKIHHFFCDILPLYRLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIF 251
Cdd:cd15410 161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 53933287 252 Y-ICLLMYIGPSEE--GDKDTPVAIFYAIVIPLLNPFIYSLRNKEVINVLKKIM 302
Cdd:cd15410 241 HgTILFMYCRPSSSysLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

11-301

2.17e-119

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 345.50 E-value: 2.17e-119

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  11 EFILIGFTNYPELKTLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDR 90
Cdd:cd15943   1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  91 IISLYECMAQFYFLCLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCR 170
Cdd:cd15943  81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 171 SNKIHHFFCDILPLYRLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSI 250
Cdd:cd15943 161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTI 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 53933287 251 FY-ICLLMYIGPSEE--GDKDTPVAIFYAIVIPLLNPFIYSLRNKEVINVLKKI 301
Cdd:cd15943 241 FYgTTLFMYLRPSSSysLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRI 294

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

12-294

3.67e-117

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 339.30 E-value: 3.67e-117

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  12 FILIGFTNYPELKTLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRI 91
Cdd:cd15408   1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  92 ISLYECMAQFYFLCLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRS 171
Cdd:cd15408  81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 172 NKIHHFFCDILPLYRLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIF 251
Cdd:cd15408 161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLF 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 53933287 252 YICLL-MYIGPSEEG--DKDTPVAIFYAIVIPLLNPFIYSLRNKEV 294
Cdd:cd15408 241 YGSLAfMYLRPSSRYslDLDKVASVFYTVVIPMLNPLIYSLRNKEV 286

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

26-291

1.11e-114

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 332.53 E-value: 1.11e-114

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd13954   2 LLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLY 185
Cdd:cd13954  82 SLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 186 RLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYI-CLLMYIGP--S 262
Cdd:cd13954 162 KLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGtIIFMYVRPssS 241

                       250       260
                ....*....|....*....|....*....
gi 53933287 263 EEGDKDTPVAIFYAIVIPLLNPFIYSLRN 291
Cdd:cd13954 242 YSSDLDKVVSVFYTVVTPMLNPIIYSLRN 270

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

26-298

5.40e-110

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 320.56 E-value: 5.40e-110

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15225   2 LLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLY 185
Cdd:cd15225  82 FLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 186 RLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYIC-LLMYIGP--S 262
Cdd:cd15225 162 KLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCaSFTYLRPksS 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 53933287 263 EEGDKDTPVAIFYAIVIPLLNPFIYSLRNKEVINVL 298
Cdd:cd15225 242 YSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

26-300

2.94e-109

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 318.82 E-value: 2.94e-109

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15417   2 ILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLY 185
Cdd:cd15417  82 GMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 186 RLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFY-ICLLMYIGPSEE 264
Cdd:cd15417 162 SLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYgTGLFVYLRPSSS 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 53933287 265 G--DKDTPVAIFYAIVIPLLNPFIYSLRNKEVINVLKK 300
Cdd:cd15417 242 HsqDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

26-294

6.89e-107

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 313.00 E-value: 6.89e-107

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15235   3 LLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFI 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLY 185
Cdd:cd15235  83 AFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 186 RLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYICLL-MYIGPSE- 263
Cdd:cd15235 163 KLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIgVYFQPSSs 242

                       250       260       270
                ....*....|....*....|....*....|..
gi 53933287 264 -EGDKDTPVAIFYAIVIPLLNPFIYSLRNKEV 294
Cdd:cd15235 243 ySADKDRVATVMYTVVTPMLNPFIYSLRNKDV 274

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

16-302

3.38e-105

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 308.91 E-value: 3.38e-105

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  16 GFTNYPELKTLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLY 95
Cdd:cd15406   1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  96 ECMAQFYFLCLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIH 175
Cdd:cd15406  81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 176 HFFCDILPLYRLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYICL 255
Cdd:cd15406 161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 53933287 256 L-MYIGPS--EEGDKDTPVAIFYAIVIPLLNPFIYSLRNKEVINVLKKIM 302
Cdd:cd15406 241 IfMYLKPSssSSMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKVL 290

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

12-300

1.38e-104

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 307.83 E-value: 1.38e-104

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  12 FILIGFTNYPELKTLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRI 91
Cdd:cd15945   1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  92 ISLYECMAQFYFLCLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRS 171
Cdd:cd15945  81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 172 NKIHHFFCDILPLYRLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIF 251
Cdd:cd15945 161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 53933287 252 YICLL-MYIGPSEEG--DKDTPVAIFYAIVIPLLNPFIYSLRNKEVINVLKK 300
Cdd:cd15945 241 YGTLLfMYLRPSSSYslDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

25-300

1.11e-102

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 302.31 E-value: 1.11e-102

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFL 104
Cdd:cd15411   1 VPLFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 105 CLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPL 184
Cdd:cd15411  81 IALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 185 YRLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFY-ICLLMYIGPSE 263
Cdd:cd15411 161 LKLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYgTGIFTYLRPSS 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 53933287 264 EG--DKDTPVAIFYAIVIPLLNPFIYSLRNKEVINVLKK 300
Cdd:cd15411 241 SYslGQDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

26-300

1.26e-99

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 294.60 E-value: 1.26e-99

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15419   2 LLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLY 185
Cdd:cd15419  82 LFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 186 RLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFY-ICLLMYIGPSEE 264
Cdd:cd15419 162 KLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYgTVFFMYAQPGAV 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 53933287 265 G--DKDTPVAIFYAIVIPLLNPFIYSLRNKEVINVLKK 300
Cdd:cd15419 242 SspEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

25-291

3.29e-99

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 293.24 E-value: 3.29e-99

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFL 104
Cdd:cd15911   1 ILLFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 105 CLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPL 184
Cdd:cd15911  81 GSLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 185 YRLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYICL-LMYIGPSE 263
Cdd:cd15911 161 LKLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLiIVYVVPST 240

                       250       260       270
                ....*....|....*....|....*....|
gi 53933287 264 EGDKDTP--VAIFYAIVIPLLNPFIYSLRN 291
Cdd:cd15911 241 NTSRDLNkvFSLFYTVLTPLVNPLIYSLRN 270

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

26-291

2.12e-97

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 288.61 E-value: 2.12e-97

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15912   2 LLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLY 185
Cdd:cd15912  82 FLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 186 RLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFY-ICLLMYIGPSEE 264
Cdd:cd15912 162 KLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYgSCIFMYVRPSQS 241

                       250       260
                ....*....|....*....|....*....
gi 53933287 265 GDKDTP--VAIFYAIVIPLLNPFIYSLRN 291
Cdd:cd15912 242 SSLDLNkvVALLNTVVTPLLNPFIYTLRN 270

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

25-291

5.51e-97

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 287.59 E-value: 5.51e-97

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFL 104
Cdd:cd15918   1 QLLFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 105 CLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPL 184
Cdd:cd15918  81 LLFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 185 YRLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYICLLM-YIGPS- 262
Cdd:cd15918 161 LKLSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGvYLSPPs 240

                       250       260       270
                ....*....|....*....|....*....|
gi 53933287 263 -EEGDKDTPVAIFYAIVIPLLNPFIYSLRN 291
Cdd:cd15918 241 sHSASKDSVAAVMYTVVTPMLNPFIYSLRN 270

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

25-291

1.00e-96

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 286.85 E-value: 1.00e-96

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFL 104
Cdd:cd15232   1 VLLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 105 CLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPL 184
Cdd:cd15232  81 TWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 185 YRLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYICLL-MYIGPSE 263
Cdd:cd15232 161 LLLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIyTYIRPSS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 53933287 264 --EGDKDTPVAIFYAIVIPLLNPFIYSLRN 291
Cdd:cd15232 241 sySPEKDKVVAVLYSVVTPTLNPLIYSLRN 270

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

26-294

4.37e-96

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 285.31 E-value: 4.37e-96

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15231   2 LLFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLY 185
Cdd:cd15231  82 SFVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 186 RLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFY-ICLLMYIGPSE- 263
Cdd:cd15231 162 KLSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYgTAIFNYNRPSSg 241

                       250       260       270
                ....*....|....*....|....*....|..
gi 53933287 264 -EGDKDTPVAIFYAIVIPLLNPFIYSLRNKEV 294
Cdd:cd15231 242 ySLDKDTLISVLYSIVTPMLNPIIYSLRNKEV 273

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

25-298

7.73e-96

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 284.83 E-value: 7.73e-96

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQ-FYF 103
Cdd:cd15421   1 LFLFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQiFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 104 LCLAeTTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILP 183
Cdd:cd15421  81 LTLG-GAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPA 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 184 LYRLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFY-ICLLMYIGP- 261
Cdd:cd15421 160 LLKLSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYgPAIFTYMRPg 239

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 53933287 262 -SEEGDKDTPVAIFYAIVIPLLNPFIYSLRNKEVINVL 298
Cdd:cd15421 240 sYHSPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

26-300

1.75e-95

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 283.91 E-value: 1.75e-95

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15412   2 LLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLY 185
Cdd:cd15412  82 ALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 186 RLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYICLL-MYIGPSEE 264
Cdd:cd15412 162 KLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFcMYLRPPSE 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 53933287 265 G--DKDTPVAIFYAIVIPLLNPFIYSLRNKEVINVLKK 300
Cdd:cd15412 242 EsvEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

26-294

2.04e-95

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 283.72 E-value: 2.04e-95

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15229   2 FLFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLY 185
Cdd:cd15229  82 FFAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 186 RLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYIC-LLMYIGPSEE 264
Cdd:cd15229 162 PLSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTgFFRYLRPNSA 241

                       250       260       270
                ....*....|....*....|....*....|..
gi 53933287 265 G--DKDTPVAIFYAIVIPLLNPFIYSLRNKEV 294
Cdd:cd15229 242 SssVLDRVFSIQYSILTPMLNPIIYSLKNKEV 273

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

27-300

2.10e-95

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 283.93 E-value: 2.10e-95

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  27 LFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLCL 106
Cdd:cd15407   3 LFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 107 AETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLYR 186
Cdd:cd15407  83 FATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLA 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 187 LSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYICLL-MYIGPSEEG 265
Cdd:cd15407 163 LSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIfMYLQPSSSH 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 53933287 266 --DKDTPVAIFYAIVIPLLNPFIYSLRNKEVINVLKK 300
Cdd:cd15407 243 smDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

27-300

2.77e-95

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 283.44 E-value: 2.77e-95

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  27 LFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLCL 106
Cdd:cd15413   3 LFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 107 AETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLYR 186
Cdd:cd15413  83 FIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLA 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 187 LSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYICLL-MYIGP--SE 263
Cdd:cd15413 163 LSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIfMYLQPksSH 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 53933287 264 EGDKDTPVAIFYAIVIPLLNPFIYSLRNKEVINVLKK 300
Cdd:cd15413 243 SLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

26-303

2.54e-94

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 281.24 E-value: 2.54e-94

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15414   2 PLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLY 185
Cdd:cd15414  82 LFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 186 RLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYICL-LMYIGPSEE 264
Cdd:cd15414 162 SLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLfFIYVRPSSS 241

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 53933287 265 G--DKDTPVAIFYAIVIPLLNPFIYSLRNKEVINVLKKIMR 303
Cdd:cd15414 242 SslDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIR 282

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

25-300

2.95e-94

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 280.84 E-value: 2.95e-94

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFL 104
Cdd:cd15415   1 VPLFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 105 CLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPL 184
Cdd:cd15415  81 AVFVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 185 YRLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYICL-LMYIGPSE 263
Cdd:cd15415 161 LKLSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVsFSYIQPSS 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 53933287 264 EG--DKDTPVAIFYAIVIPLLNPFIYSLRNKEVINVLKK 300
Cdd:cd15415 241 QYslEQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

25-291

7.39e-94

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 279.55 E-value: 7.39e-94

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQ-FYF 103
Cdd:cd15237   1 ILLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQmFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 104 LCLAeTTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILP 183
Cdd:cd15237  81 LALG-VTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPA 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 184 LYRLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFY-ICLLMYIGP- 261
Cdd:cd15237 160 VLKLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYgTAIFMYMRPh 239

                       250       260       270
                ....*....|....*....|....*....|.
gi 53933287 262 -SEEGDKDTPVAIFYAIVIPLLNPFIYSLRN 291
Cdd:cd15237 240 sTHSPDQDKMISVFYTIVTPMLNPLIYSLRN 270

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

26-291

2.38e-93

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 278.18 E-value: 2.38e-93

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15227   2 LHFVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLY 185
Cdd:cd15227  82 FFAASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 186 RLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYI-CLLMYIGPSEE 264
Cdd:cd15227 162 KLSCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLStGSFAYLKPPSD 241

                       250       260
                ....*....|....*....|....*....
gi 53933287 265 --GDKDTPVAIFYAIVIPLLNPFIYSLRN 291
Cdd:cd15227 242 spSLLDLLLSVFYSVVPPTLNPIIYSLRN 270

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

12-302

1.38e-92

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 277.05 E-value: 1.38e-92

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  12 FILIGFTNYPELKTLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRI 91
Cdd:cd15944   1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  92 ISLYECMAQFYFLCLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRS 171
Cdd:cd15944  81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 172 NKIHHFFCDILPLYRLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIF 251
Cdd:cd15944 161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 53933287 252 Y-ICLLMYIGP--SEEGDKDTPVAIFYAIVIPLLNPFIYSLRNKEVINVLKKIM 302
Cdd:cd15944 241 YgTVIFMYLRPtsVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

25-300

1.55e-92

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 276.56 E-value: 1.55e-92

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFL 104
Cdd:cd15416   1 IILFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 105 CLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPL 184
Cdd:cd15416  81 ATFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 185 YRLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFY-ICLLMYIGP-- 261
Cdd:cd15416 161 LKLSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYgTITFIYVMPns 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 53933287 262 SEEGDKDTPVAIFYAIVIPLLNPFIYSLRNKEVINVLKK 300
Cdd:cd15416 241 SYSMDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

26-294

9.99e-88

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 264.19 E-value: 9.99e-88

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15420   2 LLFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLY 185
Cdd:cd15420  82 ALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 186 RLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFY-ICLLMYIGP--S 262
Cdd:cd15420 162 KLACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYgTAMFMYMVPgsS 241

                       250       260       270
                ....*....|....*....|....*....|..
gi 53933287 263 EEGDKDTPVAIFYAIVIPLLNPFIYSLRNKEV 294
Cdd:cd15420 242 NSAEQEKILSLFYSLFNPMLNPLIYSLRNKQV 273

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

27-294

4.66e-86

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 260.04 E-value: 4.66e-86

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  27 LFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLCL 106
Cdd:cd15405   3 LFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 107 AETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLYR 186
Cdd:cd15405  83 FVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQ 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 187 LSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFY-ICLLMYIGPSEEG 265
Cdd:cd15405 163 LSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFgSGAFMYLKPSSVG 242

                       250       260       270
                ....*....|....*....|....*....|.
gi 53933287 266 --DKDTPVAIFYAIVIPLLNPFIYSLRNKEV 294
Cdd:cd15405 243 svNQGKVSSVFYTNVVPMLNPLIYSLRNKDV 273

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

25-291

1.23e-85

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 258.69 E-value: 1.23e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFL 104
Cdd:cd15431   1 IILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYIS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 105 CLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVgLLLRLTFCRSNKIHHFFCDILPL 184
Cdd:cd15431  81 LFLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPV-LTMPLHFCGPNVINHFFCEVQAL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 185 YRLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFY-ICLLMYIGPS- 262
Cdd:cd15431 160 LKLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYgTAIFMYLRPQs 239

                       250       260       270
                ....*....|....*....|....*....|
gi 53933287 263 -EEGDKDTPVAIFYAIVIPLLNPFIYSLRN 291
Cdd:cd15431 240 kSSSDQDKIISVFYGVVTPMLNPLIYSLRN 269

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

26-291

3.32e-85

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 257.60 E-value: 3.32e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15224   2 LLFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLY 185
Cdd:cd15224  82 SLACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 186 RLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFY-ICLLMYIGPSEE 264
Cdd:cd15224 162 NLSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYsATLFMYARPKAI 241

                       250       260
                ....*....|....*....|....*....
gi 53933287 265 GDKDTP--VAIFYAIVIPLLNPFIYSLRN 291
Cdd:cd15224 242 SSFDSNklVSVLYTVVTPLLNPIIYCLRN 270

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

26-300

9.18e-85

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 256.63 E-value: 9.18e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15418   3 ILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLY 185
Cdd:cd15418  83 GLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLV 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 186 RLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYICLL-MYIGPSEE 264
Cdd:cd15418 163 KLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILfIYSRPSSS 242

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 53933287 265 G--DKDTPVAIFYAIVIPLLNPFIYSLRNKEVINVLKK 300
Cdd:cd15418 243 HtpDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKK 280

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

27-291

4.33e-82

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 249.46 E-value: 4.33e-82

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  27 LFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFY-FLC 105
Cdd:cd15947   3 LFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYiFLW 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 106 LAeTTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLY 185
Cdd:cd15947  83 LG-STECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 186 RLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYICLL-MYIGPSEE 264
Cdd:cd15947 162 KLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIyMYLQPPSS 241

                       250       260
                ....*....|....*....|....*....
gi 53933287 265 GDKDTP--VAIFYAIVIPLLNPFIYSLRN 291
Cdd:cd15947 242 YSQDQGkfISLFYTVVTPTLNPLIYTLRN 270

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

26-294

2.47e-81

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 247.75 E-value: 2.47e-81

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSED-RIISLYECMAQFYFL 104
Cdd:cd15916   2 LLFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGgKVISFGGCVAQLYFF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 105 CLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPL 184
Cdd:cd15916  82 HFLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 185 YRLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYI-CLLMYIGPSE 263
Cdd:cd15916 162 LKLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVpCVFIYLRPGS 241

                       250       260       270
                ....*....|....*....|....*....|.
gi 53933287 264 EGDKDTPVAIFYAIVIPLLNPFIYSLRNKEV 294
Cdd:cd15916 242 KEALDGVIAVFYTVVTPLLNPLIYTLRNKEV 272

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

25-291

8.29e-81

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 246.45 E-value: 8.29e-81

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFL 104
Cdd:cd15915   1 IFLFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 105 CLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPL 184
Cdd:cd15915  81 HFLGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 185 YRLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKM-KSKEGRGKAFSTCASHFLSVSIFYI-CLLMYIGPS 262
Cdd:cd15915 161 LKLACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLLLKvRSKEGRHKAFSTCASHLTVVLLLYGpALFTYIRPS 240

                       250       260       270
                ....*....|....*....|....*....|.
gi 53933287 263 EEG--DKDTPVAIFYAIVIPLLNPFIYSLRN 291
Cdd:cd15915 241 SGDslEQDRIVALLYTVVTPVLNPLIYTLRN 271

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

27-298

9.10e-81

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 246.54 E-value: 9.10e-81

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  27 LFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLCL 106
Cdd:cd15429   3 LFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 107 AETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLYR 186
Cdd:cd15429  83 LGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVR 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 187 LSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFY-ICLLMYI----GP 261
Cdd:cd15429 163 LACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYgTAIFTYMrprsGS 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 53933287 262 SEEGDKdtPVAIFYAIVIPLLNPFIYSLRNKEVINVL 298
Cdd:cd15429 243 SALQEK--MISLFYAVVTPMLNPLIYSLRNKEVKGAL 277

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

26-294

4.80e-79

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 241.95 E-value: 4.80e-79

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15424   2 LLFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIAL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLY 185
Cdd:cd15424  82 SLGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 186 RLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFY-ICLLMYIGPSEE 264
Cdd:cd15424 162 KLACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYgTVISMYMRPRSG 241

                       250       260       270
                ....*....|....*....|....*....|..
gi 53933287 265 G--DKDTPVAIFYAIVIPLLNPFIYSLRNKEV 294
Cdd:cd15424 242 StpDRDKQIAVFYIVITPLLNPIIYTLRNKDV 273

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

25-291

5.85e-79

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 241.51 E-value: 5.85e-79

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFL 104
Cdd:cd15430   1 ILLFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 105 CLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPL 184
Cdd:cd15430  81 LAMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 185 YRLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFY-ICLLMYIGPSE 263
Cdd:cd15430 161 LKLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYgTILFMYMKPKS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 53933287 264 EGDK--DTPVAIFYAIVIPLLNPFIYSLRN 291
Cdd:cd15430 241 KNAQisDKLITLFYGVVTPMLNPIIYSLRN 270

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

26-291

1.56e-77

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 237.88 E-value: 1.56e-77

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15939   2 ICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLY 185
Cdd:cd15939  82 FFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 186 RLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVfKMKSKEGRGKAFSTCASHFLSVSIFYI-CLLMYIGPSEE 264
Cdd:cd15939 162 KLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSL-RTHSSEGRRKALSTCGSHITVVVLFFVpCIFIYMRPVTT 240

                       250       260
                ....*....|....*....|....*..
gi 53933287 265 GDKDTPVAIFYAIVIPLLNPFIYSLRN 291
Cdd:cd15939 241 FPIDKVVAVFYTIITPMLNPLIYTLRN 267

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

25-291

4.42e-77

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 236.83 E-value: 4.42e-77

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFL 104
Cdd:cd15913   1 ILLFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 105 CLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPL 184
Cdd:cd15913  81 FSLGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 185 YRLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFY-ICLLMYIGPS- 262
Cdd:cd15913 161 LALSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYgSVMVMYVSPGs 240

                       250       260       270
                ....*....|....*....|....*....|
gi 53933287 263 -EEGDKDTPVAIFYAIVIPLLNPFIYSLRN 291
Cdd:cd15913 241 gNSTGMQKIVTLFYSVVTPLLNPLIYSLRN 270

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

26-291

6.99e-77

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 236.18 E-value: 6.99e-77

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15940   2 AFFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLY 185
Cdd:cd15940  82 LFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 186 RLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMkSKEGRGKAFSTCASHFLSVSIFY-ICLLMYIGPSEE 264
Cdd:cd15940 162 KLACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKR-STEGRRKALSTCASHLTVVTLFFgPCIFIYTRPSTS 240

                       250       260
                ....*....|....*....|....*..
gi 53933287 265 GDKDTPVAIFYAIVIPLLNPFIYSLRN 291
Cdd:cd15940 241 FSEDKVVSVFYTVVTPLLNPIIYTLRN 267

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

26-298

1.05e-76

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 235.93 E-value: 1.05e-76

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15234   2 LLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLY 185
Cdd:cd15234  82 LFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 186 RLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFY-ICLLMYIGP--S 262
Cdd:cd15234 162 KLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYgTGLGVYISSavT 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 53933287 263 EEGDKDTPVAIFYAIVIPLLNPFIYSLRNKEVINVL 298
Cdd:cd15234 242 HSSRKTAVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

25-294

7.60e-76

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 233.86 E-value: 7.60e-76

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFL 104
Cdd:cd15228   1 TILFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFY 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 105 CLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPL 184
Cdd:cd15228  81 HFLGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 185 YRLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFY-ICLLMYIGPSE 263
Cdd:cd15228 161 LKLACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFgPCALIYTQPTP 240

                       250       260       270
                ....*....|....*....|....*....|.
gi 53933287 264 EGDKDTPVAIFYAIVIPLLNPFIYSLRNKEV 294
Cdd:cd15228 241 SPVLVTPVQIFNNVVTPMLNPLIYTLRNKEV 271

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

26-298

7.31e-75

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 231.21 E-value: 7.31e-75

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15428   2 LLFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLY 185
Cdd:cd15428  82 SFGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 186 RLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFY-ICLLMYIGPSEE 264
Cdd:cd15428 162 KLASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYgSVLSTYMRPKSS 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 53933287 265 GDK--DTPVAIFYAIVIPLLNPFIYSLRNKEVINVL 298
Cdd:cd15428 242 TSKeyDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

26-291

8.57e-75

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 230.94 E-value: 8.57e-75

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15226   2 FLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLY 185
Cdd:cd15226  82 FFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 186 RLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKmKSKEGRGKAFSTCASHFLSVSIFYI-CLLMYIGPSEE 264
Cdd:cd15226 162 KLACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRK-HSSGGSSKALSTCSAHITVVVLFFGpCIFIYVWPFST 240

                       250       260
                ....*....|....*....|....*..
gi 53933287 265 GDKDTPVAIFYAIVIPLLNPFIYSLRN 291
Cdd:cd15226 241 FPVDKFLAVFYTVITPLLNPIIYTLRN 267

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

26-294

3.59e-73

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 226.96 E-value: 3.59e-73

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15236   2 VFFALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLY 185
Cdd:cd15236  82 FFGCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 186 RLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFY---ICLLMYIGPS 262
Cdd:cd15236 162 KLSCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYgtiIGVYFFPSSN 241

                       250       260       270
                ....*....|....*....|....*....|..
gi 53933287 263 EEGDKDTPVAIFYAIVIPLLNPFIYSLRNKEV 294
Cdd:cd15236 242 NSSDKDIVASVMYTVVTPMLNPFIYSLRNRDI 273

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

26-294

5.49e-73

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 226.49 E-value: 5.49e-73

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15434   2 ILSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIAL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLY 185
Cdd:cd15434  82 GLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 186 RLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYICLL-MYIGP--S 262
Cdd:cd15434 162 KLACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIyMYLQPknS 241

                       250       260       270
                ....*....|....*....|....*....|..
gi 53933287 263 EEGDKDTPVAIFYAIVIPLLNPFIYSLRNKEV 294
Cdd:cd15434 242 VSQDQGKFLTLFYTIVTPSLNPLIYTLRNKDV 273

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

26-294

5.87e-73

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 226.60 E-value: 5.87e-73

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15233   2 VLFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLY 185
Cdd:cd15233  82 LLAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLF 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 186 RLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYICLL---MYIGPS 262
Cdd:cd15233 162 QLSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVfsyMRLGSV 241

                       250       260       270
                ....*....|....*....|....*....|..
gi 53933287 263 EEGDKDTPVAIFYAIVIPLLNPFIYSLRNKEV 294
Cdd:cd15233 242 YSSDKDKVIGILNTVLSPMLNPLIYSLRNKDV 273

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

25-294

7.13e-72

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 223.89 E-value: 7.13e-72

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFL 104
Cdd:cd15432   1 MVLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 105 CLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPL 184
Cdd:cd15432  81 LGLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPAL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 185 YRLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFY---ICLLMYIGP 261
Cdd:cd15432 161 LKLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYgtaISMYLQPPS 240

                       250       260       270
                ....*....|....*....|....*....|...
gi 53933287 262 SEEGDKDTPVAIFYAIVIPLLNPFIYSLRNKEV 294
Cdd:cd15432 241 NSSHDRGKMVALFYGIITPMLNPLIYTLRNKDV 273

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

26-291

1.22e-71

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 222.59 E-value: 1.22e-71

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15936   2 FLFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLY 185
Cdd:cd15936  82 FTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 186 RLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVfKMKSKEGRGKAFSTCASHFLSVS-IFYICLLMYIGPSEE 264
Cdd:cd15936 162 KLACTDTFLLELLMVSNSGLVTLLIFFILLISYTVILVKI-RTHVTEGKRKALSTCASQITVVTlIFVPCIYIYARPFQT 240

                       250       260
                ....*....|....*....|....*..
gi 53933287 265 GDKDTPVAIFYAIVIPLLNPFIYSLRN 291
Cdd:cd15936 241 FPMDKAVSVLYTVITPMLNPMIYTLRN 267

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

26-291

1.82e-69

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 217.35 E-value: 1.82e-69

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15946   2 ILFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLY 185
Cdd:cd15946  82 ALGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 186 RLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYI-CLLMYIGP--S 262
Cdd:cd15946 162 KLACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGpAMFMYMRPgsN 241

                       250       260
                ....*....|....*....|....*....
gi 53933287 263 EEGDKDTPVAIFYAIVIPLLNPFIYSLRN 291
Cdd:cd15946 242 YSPERDKKISLFYNVFTALLNPVIYSLRN 270

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

25-291

2.87e-69

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 216.85 E-value: 2.87e-69

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFL 104
Cdd:cd15914   1 LLLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 105 CLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPL 184
Cdd:cd15914  81 HSLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 185 YRLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFY-ICLLMYIGPSE 263
Cdd:cd15914 161 LSLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFgSVSFMYLRLSK 240

                       250       260       270
                ....*....|....*....|....*....|
gi 53933287 264 --EGDKDTPVAIFYAIVIPLLNPFIYSLRN 291
Cdd:cd15914 241 sySLDYDRAIAVVYAVLTPFFNPIIYSLRN 270

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

26-298

9.87e-68

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 213.17 E-value: 9.87e-68

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLT-PMYIFLGNLALMDSCCSCAVTPKMLENFFSED-RIISLYECMAQFYF 103
Cdd:cd15941   2 LFFLLFLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSgRTISFEGCVVQLYA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 104 LCLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILP 183
Cdd:cd15941  82 FHFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPP 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 184 LYRLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYI-CLLMYIGPS 262
Cdd:cd15941 162 VLKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVpSVFIYLQPS 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 53933287 263 EEGDKDTPVAIFYAIVIPLLNPFIYSLRNKEVINVL 298
Cdd:cd15941 242 SSQAGAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

25-291

1.19e-67

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 212.70 E-value: 1.19e-67

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLL-TPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYF 103
Cdd:cd15935   1 LLLFVLVLACYAAILLGNLLIVVTVHADPHLLqSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 104 LCLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILP 183
Cdd:cd15935  81 LHFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQ 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 184 LYRLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVfKMKSKEGRGKAFSTCASHFLSVSIFYI-CLLMYIGPS 262
Cdd:cd15935 161 VIKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTTL-RGRFREGGGKALSTCSSHLTVVSLIFVpCIFVYLRPF 239

                       250       260
                ....*....|....*....|....*....
gi 53933287 263 EEGDKDTPVAIFYAIVIPLLNPFIYSLRN 291
Cdd:cd15935 240 SSSSVDKVASVFYTLITPALNPLIYTLRN 268

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

27-298

5.41e-66

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 208.44 E-value: 5.41e-66

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  27 LFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLCL 106
Cdd:cd15942   3 LFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 107 AETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLYR 186
Cdd:cd15942  83 LGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 187 LSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYI-CLLMYIGPSEEG 265
Cdd:cd15942 163 LACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVpLTFIYLRPGSQD 242

                       250       260       270
                ....*....|....*....|....*....|...
gi 53933287 266 DKDTPVAIFYAIVIPLLNPFIYSLRNKEVINVL 298
Cdd:cd15942 243 PLDGVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

26-291

1.90e-65

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 207.03 E-value: 1.90e-65

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15938   2 LLFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLY 185
Cdd:cd15938  82 FVGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 186 RLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVfkmKSKEGRGKAFSTCASHFLSVSIFYI-CLLMYIGPSEE 264
Cdd:cd15938 162 KLACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTILVTI---RSTEGRRKALSTCASHLMVVTLFFGpCIFIYARPFST 238

                       250       260
                ....*....|....*....|....*..
gi 53933287 265 GDKDTPVAIFYAIVIPLLNPFIYSLRN 291
Cdd:cd15938 239 FPVDKHVSVLYNVITPMLNPLIYTLRN 265

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

26-291

1.15e-57

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 186.87 E-value: 1.15e-57

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15937   2 LLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLY 185
Cdd:cd15937  82 FLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 186 RLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVfKMKSKEGRGKAFSTCASHFLSVSI-FYICLLMYIGPSEE 264
Cdd:cd15937 162 KLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAKL-RTHSSKGKSKAASTCITHIIIVFVmFGPAIYIYARPFRS 240

                       250       260
                ....*....|....*....|....*..
gi 53933287 265 GDKDTPVAIFYAIVIPLLNPFIYSLRN 291
Cdd:cd15937 241 FPMDKVVAVFHTVIFPLLNPMIYTLRN 267

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

26-294

1.56e-57

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 186.92 E-value: 1.56e-57

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15433   2 VLFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLY 185
Cdd:cd15433  82 ALGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 186 RLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFY---ICLLMYIGPS 262
Cdd:cd15433 162 KLACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYgsaIYTYLQPIHR 241

                       250       260       270
                ....*....|....*....|....*....|..
gi 53933287 263 EEGDKDTPVAIFYAIVIPLLNPFIYSLRNKEV 294
Cdd:cd15433 242 YSQAHGKFVSLFYTVMTPALNPLIYTLRNKDV 273

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

26-294

1.93e-57

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 186.73 E-value: 1.93e-57

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15223   2 WLSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLY 185
Cdd:cd15223  82 FFTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 186 RLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYICLLMYI-----G 260
Cdd:cd15223 162 SLACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSltyrfG 241

                       250       260       270
                ....*....|....*....|....*....|....
gi 53933287 261 PSEEGDKDTPVAIFYAIVIPLLNPFIYSLRNKEV 294
Cdd:cd15223 242 KTIPPDVHVLLSVLYILIPPALNPIIYGVRTKEI 275

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

29-294

2.75e-54

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 178.25 E-value: 2.75e-54

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  29 VVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLCLAE 108
Cdd:cd15917   5 IPFCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFT 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 109 TTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLYRLS 188
Cdd:cd15917  85 AMESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 189 CTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYICLLMYIGPSEEGDKD 268
Cdd:cd15917 165 CGDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRFGHHV 244

                       250       260       270
                ....*....|....*....|....*....|.
gi 53933287 269 TP-----VAIFYAIVIPLLNPFIYSLRNKEV 294
Cdd:cd15917 245 PPhvhilLANLYLLLPPMLNPIVYGVRTKQI 275

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

31-294

1.26e-50

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 169.01 E-value: 1.26e-50

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  31 FSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLCLAETT 110
Cdd:cd15221   7 FCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVT 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 111 DCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLYRLSCT 190
Cdd:cd15221  87 ESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 191 DPSINelMIYIFSIPIQIFTIATVLI--SYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYICLLMYI-----GPSE 263
Cdd:cd15221 167 DITVN--IWYGLTVALLTVGLDVVLIavSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFlthrfGRHI 244

                       250       260       270
                ....*....|....*....|....*....|.
gi 53933287 264 EGDKDTPVAIFYAIVIPLLNPFIYSLRNKEV 294
Cdd:cd15221 245 PRHVHILLANLYVLVPPMLNPIVYGVKTKQI 275

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

31-294

8.46e-50

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 166.67 E-value: 8.46e-50

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  31 FSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLCLAETT 110
Cdd:cd15953   7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 111 DCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLYRLSCT 190
Cdd:cd15953  87 ESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLACG 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 191 DPSINelMIYIFSIPIQIFTIATVLI--SYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYICLLMYIGPSEEGDKD 268
Cdd:cd15953 167 DTTIN--RIYGLVVALLVVGLDLLLIalSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLTHRFGQGI 244

                       250       260       270
                ....*....|....*....|....*....|.
gi 53933287 269 TP-----VAIFYAIVIPLLNPFIYSLRNKEV 294
Cdd:cd15953 245 APhihiiLANLYLLVPPMLNPIIYGVKTKEI 275

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

31-294

3.84e-49

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 165.28 E-value: 3.84e-49

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  31 FSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLCLAETT 110
Cdd:cd15950   7 FCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAV 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 111 DCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLYRLSCT 190
Cdd:cd15950  87 ESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 191 DPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYI--CLLMYIgpsEEGDKD 268
Cdd:cd15950 167 DPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIpgLLSIYT---QRFGQG 243

                       250       260       270
                ....*....|....*....|....*....|..
gi 53933287 269 TP------VAIFYAIVIPLLNPFIYSLRNKEV 294
Cdd:cd15950 244 VPphtqvlLADLYLLVPPMLNPIIYGMRTKQI 275

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

27-294

8.16e-46

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 156.51 E-value: 8.16e-46

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  27 LFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYF--- 103
Cdd:cd15222   3 ISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFiht 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 104 LCLAETTdcFLLAtMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFC---D 180
Cdd:cd15222  83 FSFMESS--VLLA-MAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYClhqD 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 181 ILplyRLSCTDPSINElmIYIFSIPIQIFTIATVLI--SYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYICLlmy 258
Cdd:cd15222 160 VM---KLACSDTRVNS--IYGLFVVLSTMGLDSLLIllSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPM--- 231

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 53933287 259 IGPS---EEGDKDTPV-----AIFYAIVIPLLNPFIYSLRNKEV 294
Cdd:cd15222 232 IGLSmvhRFGKHASPLvhvlmANVYLLVPPVLNPIIYSVKTKQI 275

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

31-294

3.07e-45

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 154.85 E-value: 3.07e-45

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  31 FSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLCLAETT 110
Cdd:cd15952   7 FCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 111 DCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLYRLSCT 190
Cdd:cd15952  87 ESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 191 DPSINeLMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYICLLMYIGPSEEGdKDTP 270
Cdd:cd15952 167 SIRIN-IIYGLFAISVLVLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRFG-HNIP 244

                       250       260       270
                ....*....|....*....|....*....|
gi 53933287 271 ------VAIFYAIVIPLLNPFIYSLRNKEV 294
Cdd:cd15952 245 ryihilLANLYVVLPPMLNPVIYGVRTKQI 274

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

31-294

1.18e-43

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 150.96 E-value: 1.18e-43

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  31 FSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLCLAETT 110
Cdd:cd15951   7 FCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 111 DCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLYRLSCT 190
Cdd:cd15951  87 ESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 191 DPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYICLLMYIGPSEEGDKDTP 270
Cdd:cd15951 167 DTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLTHRFGHNVPP 246

                       250       260
                ....*....|....*....|....*....
gi 53933287 271 -----VAIFYAIVIPLLNPFIYSLRNKEV 294
Cdd:cd15951 247 hvhilIANVYLLVPPMLNPIIYGVRTKQI 275

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

31-294

2.22e-43

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 150.44 E-value: 2.22e-43

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  31 FSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLCLAETT 110
Cdd:cd15948   8 FCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIM 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 111 DCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLYRLSCT 190
Cdd:cd15948  88 ESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLACG 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 191 DPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYICLLMYIGPSEEGDKDTP 270
Cdd:cd15948 168 DTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSSTMHRFARHVAP 247

                       250       260
                ....*....|....*....|....*....
gi 53933287 271 -----VAIFYAIVIPLLNPFIYSLRNKEV 294
Cdd:cd15948 248 hvhilLANFYLLFPPMMNPIVYGVKTKQI 276

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

10-294

1.23e-41

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 146.08 E-value: 1.23e-41

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  10 AEFILIGFTNYPELKTLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSED 89
Cdd:cd15949   2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  90 RIISLYECMAQFYFLCLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFC 169
Cdd:cd15949  82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 170 RSNKIHHFFCDILPLYRLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVS 249
Cdd:cd15949 162 RTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAIL 241

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 53933287 250 IFYI-----CLLMYIGPSEEGDKDTPVAIFYAIVIPLLNPFIYSLRNKEV 294
Cdd:cd15949 242 AFYVpiavsSLIHRFGQNVPPPTHILLANFYLLIPPMLNPIVYGVRTKQI 291

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

31-302

3.02e-39

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 139.56 E-value: 3.02e-39

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287    31 FSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLCLAETT 110
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287   111 DCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLYRLSCT 190
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287   191 DPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYICLLMYIGPSEEGDKDTP 270
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPP 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 53933287   271 -----VAIFYAIVIPLLNPFIYSLRNKEVINVLKKIM 302
Cdd:pfam13853 241 llqimMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

25-294

4.21e-39

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 139.23 E-value: 4.21e-39

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFL 104
Cdd:cd15956   1 VWLSLPFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 105 CLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTlCIRMTTGAFKAGNLHSMIHVGLLL-RLTFCRSNKIHHFFCDILP 183
Cdd:cd15956  81 HAFSAMESGVLVAMALDRFVAICNPLHYATILTLE-VVAKAGLLLALRGVAIVIPFPLLVcRLSFCASHTIAHTYCEHMA 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 184 LYRLSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYI----CLLMY- 258
Cdd:cd15956 160 VVKLACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIpgllSVLMHr 239

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 53933287 259 IGPSEEGDKDTPVAIFYAIVIPLLNPFIYSLRNKEV 294
Cdd:cd15956 240 FGHSVPSAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

31-294

9.44e-36

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 130.27 E-value: 9.44e-36

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  31 FSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLCLAETT 110
Cdd:cd15955   7 FCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAF 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 111 DCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTG-AFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLYRLSC 189
Cdd:cd15955  87 ESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLvVVRAVVLIIPCPLLIKLRLHHFRSTVISHSYCEHMAVVKLAA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 190 TDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYICLLMYIGPSEEGDKDT 269
Cdd:cd15955 167 DDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHRFGHHVA 246

                       250       260       270
                ....*....|....*....|....*....|
gi 53933287 270 P-----VAIFYAIVIPLLNPFIYSLRNKEV 294
Cdd:cd15955 247 PyvhilLSNLYLLVPPVLNPIVYGVKTKQI 276

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

31-294

6.83e-35

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 128.02 E-value: 6.83e-35

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  31 FSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLCLAETT 110
Cdd:cd15954   7 FCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 111 DCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILPLYRLSCT 190
Cdd:cd15954  87 ESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 191 DPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASHFLSVSIFYICLLMYIGPSEEGDKDTP 270
Cdd:cd15954 167 NIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHRFGGHHIT 246

                       250       260       270
                ....*....|....*....|....*....|
gi 53933287 271 ------VAIFYAIVIPLLNPFIYSLRNKEV 294
Cdd:cd15954 247 phihiiMANLYLLLPPMMNPIVYGVKTKQI 276

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

41-287

2.35e-26

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 104.69 E-value: 2.35e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287    41 GNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDR-IISLYECMAQFYFLCLAETTDCFLLATMA 119
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDwPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287   120 YDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNkihHFFCDILPLYRLSCTDPSINELMI 199
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGN---VTVCFIDFPEDLSKPVSYTLLISV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287   200 YIFSIPIQIftiatVLISYLCILLTVFKMKSKEGRG-------KAFSTCASHFLSVSIFYIC-----LLMYIGPSEEGDK 267
Cdd:pfam00001 158 LGFLLPLLV-----ILVCYTLIIRTLRKSASKQKSSertqrrrKALKTLAVVVVVFILCWLPyhivnLLDSLALDCELSR 232

                         250       260
                  ....*....|....*....|....
gi 53933287   268 DTPVAI----FYAIVIPLLNPFIY 287
Cdd:pfam00001 233 LLDKALsvtlWLAYVNSCLNPIIY 256

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

27-291

2.10e-15

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 75.02 E-value: 2.10e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  27 LFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLCL 106
Cdd:cd00637   1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 107 AETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFkagnLHSMIHVGLLLRLTFCRSNKIHHFFCdilplyr 186
Cdd:cd00637  81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIW----LLSLLLALPPLLGWGVYDYGGYCCCC------- 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 187 LSCTDPSINELMIYIFSIPIQIFTIATVLISYLCILLTVFKMKSKEGRGKAFSTCASH-----------FLSVSIFYIC- 254
Cdd:cd00637 150 LCWPDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRRRrrrerkvtktlLIVVVVFLLCw 229

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 53933287 255 -----LLMYIGPSEEGDKDTPVAIFYAIVIPLL----NPFIYSLRN 291
Cdd:cd00637 230 lpyfiLLLLDVFGPDPSPLPRILYFLALLLAYLnsaiNPIIYAFFN 275

7tmA_EDG-like

cd14972

endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...

29-294

8.75e-12

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 64.24 E-value: 8.75e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  29 VVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLeNFFSEDRIISLYECMAQFYFLCLAE 108
Cdd:cd14972   3 VVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFL-SVLLVSLTPSPATWLLRKGSLVLSL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 109 TTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMI-HVGLLLRLTFCRSnkihhffC-DILPLYR 186
Cdd:cd14972  82 LASAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALLpVLGWNCVLCDQES-------CsPLGPGLP 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 187 LSctdpsinelmiYIFSIPIqIFTIATVLIS--YLCILltvFKMKSKEGRGKAFSTCAS-HFLSVS------------IF 251
Cdd:cd14972 155 KS-----------YLVLILV-FFFIALVIIVflYVRIF---WCLWRHANAIAARQEAAVpAQPSTSrklaktvvivlgVF 219

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 53933287 252 YIC-----LLMYIGPSEEGDKDTPVAIFYAIVIPLLN----PFIYSLRNKEV 294
Cdd:cd14972 220 LVCwlpllILLVLDVLCPSVCDIQAVFYYFLVLALLNsainPIIYAFRLKEM 271

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

26-293

6.20e-11

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 61.81 E-value: 6.20e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLenffsedrIISLYECMAQFYFLC 105
Cdd:cd14967   1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSA--------VYTLLGYWPFGPVLC 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 106 --------LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKagnlhsmihVGLLLRLTFCRSNKIHHF 177
Cdd:cd14967  73 rfwialdvLCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWV---------YSLLISLPPLVGWRDETQ 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 178 FCDIlplyrlSCTDPSINELMIYIFSIPIQIFTIATVLIS-YLCILLTVFKMKskegrgKAFSTCAshfLSVSIFYIC-- 254
Cdd:cd14967 144 PSVV------DCECEFTPNKIYVLVSSVISFFIPLLIMIVlYARIFRVARREL------KAAKTLA---IIVGAFLLCwl 208

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 53933287 255 ---LLMYIGPSEEGDKDTPVAIFYAIVIP----LLNPFIYSLRNKE 293
Cdd:cd14967 209 pffIIYLVSAFCPPDCVPPILYAVFFWLGylnsALNPIIYALFNRD 254

7tmA_V1bR

cd15386

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...

30-131

1.28e-09

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320508 [Multi-domain] Cd Length: 302 Bit Score: 58.27 E-value: 1.28e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  30 VFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSC-AVTPKMLEN----FFSEDRIislyeCMAQFYFL 104
Cdd:cd15386   6 VLAAILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALfQVLPQLIWEityrFQGPDLL-----CRAVKYLQ 80

                        90       100
                ....*....|....*....|....*..
gi 53933287 105 CLAETTDCFLLATMAYDRYVAICHPLQ 131
Cdd:cd15386  81 VLSMFASTYMLIMMTVDRYIAVCHPLR 107

7tmA_CCK-BR

cd15979

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...

25-131

5.30e-07

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320645 [Multi-domain] Cd Length: 275 Bit Score: 50.20 E-value: 5.30e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFL 104
Cdd:cd15979   1 TVRILLYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLM 80

                        90       100
                ....*....|....*....|....*..
gi 53933287 105 CLAETTDCFLLATMAYDRYVAICHPLQ 131
Cdd:cd15979  81 GVSVSVSTFSLVAIAIERYSAICNPLQ 107

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

29-139

6.71e-07

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 49.93 E-value: 6.71e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  29 VVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMD-SCCSCAVTPKML----ENFFSEDRIislyeCMAQFYF 103
Cdd:cd15196   5 AVLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADlLVALFNVLPQLIwditYRFYGGDLL-----CRLVKYL 79

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 53933287 104 LCLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKT 139
Cdd:cd15196  80 QVVGMYASSYVLVATAIDRYIAICHPLSSHRWTSRR 115

7tmA_CCKR-like

cd14993

cholecystokinin receptors and related proteins, member of the class A family of ...

26-144

8.96e-07

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.

Pssm-ID: 320124 [Multi-domain] Cd Length: 296 Bit Score: 49.52 E-value: 8.96e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTP-KMLENFFSEDrIISLYECMAQFYFL 104
Cdd:cd14993   2 VLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPlTLLENVYRPW-VFGEVLCKAVPYLQ 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 53933287 105 CLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRM 144
Cdd:cd14993  81 GVSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARII 120

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

29-142

1.11e-06

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 49.13 E-value: 1.11e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  29 VVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLCLAE 108
Cdd:cd14969   5 VYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLG 84

                        90       100       110
                ....*....|....*....|....*....|....
gi 53933287 109 TTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCI 142
Cdd:cd14969  85 LVSISTLAALAFERYLVIVRPLKAFRLSKRRALI 118

7tmA_TACR-like

cd15202

tachykinin receptors and related receptors, member of the class A family of ...

26-142

1.77e-06

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320330 [Multi-domain] Cd Length: 288 Bit Score: 48.66 E-value: 1.77e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15202   2 LLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQY 81

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCI 142
Cdd:cd15202  82 CSVHVSAYTLTAIAVDRYQAIMHPLKPRISKTKAKFI 118

7tmA_GPRnna14-like

cd15001

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...

28-147

3.37e-06

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320132 [Multi-domain] Cd Length: 266 Bit Score: 47.66 E-value: 3.37e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  28 FVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLCLA 107
Cdd:cd15001   3 IIVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLS 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 53933287 108 ETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTG 147
Cdd:cd15001  83 FICSVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALL 122

7tmA_FMRFamide_R-like

cd14978

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...

29-216

5.96e-06

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.

Pssm-ID: 410630 [Multi-domain] Cd Length: 299 Bit Score: 47.24 E-value: 5.96e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  29 VVFSAIYLVTMVGNLgLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKML-----ENFFSEDRIISLYECMAQFYF 103
Cdd:cd14978   5 YVLPVICIFGIIGNI-LNLVVLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLlpyiaDYSSSFLSYFYAYFLPYIYPL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 104 LCLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGLLLRLTFCRSNKIHHFFCDILP 183
Cdd:cd14978  84 ANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVIPTL 163

                       170       180       190
                ....*....|....*....|....*....|....*
gi 53933287 184 LYRLSCTDPSINELMIYIFS--IPIQIFTIATVLI 216
Cdd:cd14978 164 LRQNETYLLKYYFWLYAIFVvlLPFILLLILNILL 198

7tmA_Trissin_R

cd15012

trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...

26-130

6.57e-06

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320140 [Multi-domain] Cd Length: 277 Bit Score: 46.67 E-value: 6.57e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15012   1 IFIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHS 80

                        90       100
                ....*....|....*....|....*
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPL 130
Cdd:cd15012  81 LSYTASIGILVVISVERYIAILHPL 105

7tmA_CCK_R

cd15206

cholecystokinin receptors, member of the class A family of seven-transmembrane G ...

26-131

7.59e-06

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320334 [Multi-domain] Cd Length: 269 Bit Score: 46.61 E-value: 7.59e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMD-----SCCSCAVTPKMLENFfsedrIISLYECMAQ 100
Cdd:cd15206   2 LIIPLYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDlllavFCMPFTLVGQLLRNF-----IFGEVMCKLI 76

                        90       100       110
                ....*....|....*....|....*....|.
gi 53933287 101 FYFLCLAETTDCFLLATMAYDRYVAICHPLQ 131
Cdd:cd15206  77 PYFQAVSVSVSTFTLVAISLERYFAICHPLK 107

7tmA_CCK-AR

cd15978

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...

25-149

1.45e-05

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320644 [Multi-domain] Cd Length: 278 Bit Score: 45.63 E-value: 1.45e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFL 104
Cdd:cd15978   1 TVRILLYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFM 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 53933287 105 CLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAF 149
Cdd:cd15978  81 GISVSVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATW 125

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

25-139

2.26e-05

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 45.24 E-value: 2.26e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPkmlenfFSEDRII-------SLYeC 97
Cdd:cd15055   1 VLLYIVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMP------FSMIRSIetcwyfgDTF-C 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 53933287  98 MAQFYFLCLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKT 139
Cdd:cd15055  74 KLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIR 115

7tmA_ETH-R

cd14997

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...

25-142

2.74e-05

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320128 [Multi-domain] Cd Length: 294 Bit Score: 44.97 E-value: 2.74e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIIsLYECMAQFYFL 104
Cdd:cd14997   1 VLVSVVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWAREPWL-LGEFMCKLVPF 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 53933287 105 CLAETTDCFLLATMA--YDRYVAICHPLQ--YHTMMSKTLCI 142
Cdd:cd14997  80 VELTVAHASVLTILAisFERYYAICHPLQakYVCTKRRALVI 121

7tmA_photoreceptors_insect

cd15079

insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...

26-131

2.94e-05

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320207 [Multi-domain] Cd Length: 292 Bit Score: 44.87 E-value: 2.94e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNlGLVALIYVERR-LLTPMYIFLGNLALMDsCCSCAVTPKMLENFFSEDRIISLYECmaQFYFL 104
Cdd:cd15079   2 LLGFIYIFLGIVSLLGN-GLVIYIFSTTKsLRTPSNMLVVNLAISD-FLMMIKMPIFIYNSFYEGWALGPLGC--QIYAF 77

                        90       100
                ....*....|....*....|....*....
gi 53933287 105 C--LAETTDCFLLATMAYDRYVAICHPLQ 131
Cdd:cd15079  78 LgsLSGIGSIWTNAAIAYDRYNVIVKPLN 106

7tmA_RNL3R

cd14976

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...

29-293

3.17e-05

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.

Pssm-ID: 320107 [Multi-domain] Cd Length: 290 Bit Score: 44.80 E-value: 3.17e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  29 VVFSAIY-LVTMVGNLGLVALIYV-----ERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFY 102
Cdd:cd14976   1 NLVSVVYmVVFTVGLLGNLLVLYLlksnkKLRQQSESNKFVFNLALTDLIFVLTLPFWAVEYALDFVWPFGTAMCKVVRY 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 103 FLCLAETTDCFLLATMAYDRYVAICHPLQYHTMM----SKTLCI---------RMTTGAFKAGNLHSMIHVGLLLRLTFC 169
Cdd:cd14976  81 VTKLNMYSSIFFLTALSVTRYIAVARALKHGWIRkafgAFATTIaiwaaaalaAIPEAIFSTDTWSSVNHTLCLLRFPKN 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 170 RSNKIHHFFCDILPLYRlsctdpsinelMIYIFSIPIQIftiatVLISYLCILLTVFKMKSKEGRGKAFSTcASHFLSVS 249
Cdd:cd14976 161 SSVTRWYNWLGMYQLQK-----------VVLGFFLPLGI-----ITLSYLLLLRFLQRKRGGSKRRKSRVT-KSVFIVVL 223

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 53933287 250 IFYICLLMYIGPSEEG------------------DKDTPVAIFYAIVIPLLNPFIYSLRNKE 293
Cdd:cd14976 224 SFFICWLPNQALSLWSalikfddvpfsdaffafqTYAFPVAICLAHSNSCLNPVLYCLVRRE 285

7tmA_Vasopressin-like

cd14986

vasopressin receptors and its related G protein-coupled receptors, member of the class A ...

30-131

3.28e-05

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.

Pssm-ID: 320117 [Multi-domain] Cd Length: 295 Bit Score: 44.67 E-value: 3.28e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  30 VFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSC-CSCAVTPKMLENFFsEDRIISLYECMAQFYFLCLAE 108
Cdd:cd14986   6 VLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVvAFFTVLTQIIWEAT-GEWVAGDVLCRIVKYLQVVGL 84

                        90       100
                ....*....|....*....|...
gi 53933287 109 TTDCFLLATMAYDRYVAICHPLQ 131
Cdd:cd14986  85 FASTYILVSMSLDRYQAIVKPMS 107

7tmA_SKR_NK2R

cd16004

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...

29-131

3.77e-05

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.

Pssm-ID: 320670 [Multi-domain] Cd Length: 285 Bit Score: 44.45 E-value: 3.77e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  29 VVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLCLAE 108
Cdd:cd16004   5 IAYSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFPITAM 84

                        90       100
                ....*....|....*....|...
gi 53933287 109 TTDCFLLATMAYDRYVAICHPLQ 131
Cdd:cd16004  85 FVSIYSMTAIAADRYMAIIHPFK 107

7tmA_Ap5-HTB1-like

cd15065

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...

26-139

6.98e-05

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.

Pssm-ID: 320193 [Multi-domain] Cd Length: 300 Bit Score: 43.88 E-value: 6.98e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15065   1 LIGIFLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDV 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKT 139
Cdd:cd15065  81 MCSTASILNLCAISLDRYIHIKKPLKYERWMTTR 114

7tmA_alpha1B_AR

cd15326

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...

26-164

7.66e-05

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320449 [Multi-domain] Cd Length: 261 Bit Score: 43.34 E-value: 7.66e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTP----KMLENFFSEDRIisLYECMAQF 101
Cdd:cd15326   2 LLGLVLGAFILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPfsatLEILGYWVFGRI--FCDIWAAV 79

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 53933287 102 YFLCLaeTTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKagnLHSMIHVGLLL 164
Cdd:cd15326  80 DVLCC--TASILSLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWV---LSTVISIGPLL 137

7tmA_TACR_family

cd14992

tachykinin receptor and closely related proteins, member of the class A family of ...

26-142

8.69e-05

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320123 [Multi-domain] Cd Length: 291 Bit Score: 43.58 E-value: 8.69e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd14992   2 ILGVALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRT 81

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCI 142
Cdd:cd14992  82 VSVYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTV 118

7tmA_TACR

cd15390

neurokinin receptors (or tachykinin receptors), member of the class A family of ...

25-131

1.23e-04

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320512 [Multi-domain] Cd Length: 289 Bit Score: 43.05 E-value: 1.23e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFL 104
Cdd:cd15390   1 VLWSIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVA 80

                        90       100
                ....*....|....*....|....*..
gi 53933287 105 CLAETTDCFLLATMAYDRYVAICHPLQ 131
Cdd:cd15390  81 ITTVAASVFTLMAISIDRYIAIVHPLR 107

7tmA_Gal2_Gal3_R

cd15097

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...

29-131

1.41e-04

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.

Pssm-ID: 320225 [Multi-domain] Cd Length: 279 Bit Score: 42.89 E-value: 1.41e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  29 VVFSAIYLVTMVGN-LGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLCLA 107
Cdd:cd15097   5 VVFSLIFLLGTVGNsLVLAVLLRSGQSGHNTTNLFILNLSVADLCFILFCVPFQATIYSLEGWVFGSFLCKAVHFFIYLT 84

                        90       100
                ....*....|....*....|....
gi 53933287 108 ETTDCFLLATMAYDRYVAICHPLQ 131
Cdd:cd15097  85 MYASSFTLAAVSVDRYLAIRYPLR 108

7tmA_V2R

cd15388

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...

30-131

2.18e-04

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320510 [Multi-domain] Cd Length: 295 Bit Score: 42.45 E-value: 2.18e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  30 VFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSC-AVTPKML----ENFFSEDRIislyeCMAQFYFL 104
Cdd:cd15388   6 VLAIIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFfQVLPQLVwditDRFRGPDVL-----CRLVKYLQ 80

                        90       100
                ....*....|....*....|....*..
gi 53933287 105 CLAETTDCFLLATMAYDRYVAICHPLQ 131
Cdd:cd15388  81 VVGMFASSYMIVAMTFDRHQAICRPMV 107

7tmA_NK1R

cd16002

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...

29-131

2.30e-04

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.

Pssm-ID: 320668 [Multi-domain] Cd Length: 284 Bit Score: 42.16 E-value: 2.30e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  29 VVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLCLAE 108
Cdd:cd16002   5 VAYSVIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNEWYYGLEYCKFHNFFPIAAV 84

                        90       100
                ....*....|....*....|...
gi 53933287 109 TTDCFLLATMAYDRYVAICHPLQ 131
Cdd:cd16002  85 FASIYSMTAIALDRYMAIIHPLQ 107

7tmA_Opioid_R-like

cd14970

opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...

25-131

2.76e-04

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.

Pssm-ID: 320101 [Multi-domain] Cd Length: 282 Bit Score: 41.90 E-value: 2.76e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNlglVALIYVERR---LLTPMYIFLGNLALMDSCCSCAVtPKMLENFFSED--------RIIS 93
Cdd:cd14970   1 IVIPAVYSVVCVVGLTGN---SLVIYVILRyskMKTVTNIYILNLAVADELFLLGL-PFLATSYLLGYwpfgevmcKIVL 76

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 53933287  94 LYECMAQFyflclaetTDCFLLATMAYDRYVAICHPLQ 131
Cdd:cd14970  77 SVDAYNMF--------TSIFCLTVMSVDRYLAVVHPVK 106

7tmA_5-HT1_5_7

cd15064

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...

26-132

3.79e-04

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320192 [Multi-domain] Cd Length: 258 Bit Score: 41.55 E-value: 3.79e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPkmlenffsedrIISLYECMAQF---Y 102
Cdd:cd15064   2 LISVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMP-----------LSAVYELTGRWilgQ 70

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 53933287 103 FLC--------LAETTDCFLLATMAYDRYVAICHPLQY 132
Cdd:cd15064  71 VLCdiwisldvTCCTASILHLCVIALDRYWAITDAVEY 108

7tmA_NTSR-like

cd14979

neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...

26-230

3.81e-04

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320110 [Multi-domain] Cd Length: 300 Bit Score: 41.57 E-value: 3.81e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDR-IISLYECMAQFYFL 104
Cdd:cd14979   2 LVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQYPwAFGDGGCKLYYFLF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287 105 CLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMtTGAFKAGNLHSMIHVGLLLRLTFcrsnkiHHFFCDILPL 184
Cdd:cd14979  82 EACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRF-ILAIWLVSILCAIPILFLMGIQY------LNGPLPGPVP 154

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 53933287 185 YRLSCTDPSINELMIYIFSIPIQIF---TIATVLISYLCILLTVFKMKS 230
Cdd:cd14979 155 DSAVCTLVVDRSTFKYVFQVSTFIFfvlPMFVISILYFRIGVKLRSMRN 203

7tmA_GPR119_R_insulinotropic_receptor

cd15104

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...

38-152

5.80e-04

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320232 [Multi-domain] Cd Length: 283 Bit Score: 40.82 E-value: 5.80e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  38 TMVGNLGLVALIYVERRL-LTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLCLAETTDCFLLA 116
Cdd:cd15104  13 IITGNLLVIVALLKLIRKkDTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFVITSCAASVLSLA 92

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 53933287 117 TMAYDRYVAICHPLQYHTMMSKtlcirMTTGAFKAG 152
Cdd:cd15104  93 AIAFDRYLALKQPLRYKQIMTG-----KSAGALIAG 123

7tmA_Dop1R2-like

cd15067

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...

26-144

6.06e-04

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.

Pssm-ID: 320195 [Multi-domain] Cd Length: 262 Bit Score: 40.80 E-value: 6.06e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTP-KMLENFFSEDRIISLYECMAQFYFL 104
Cdd:cd15067   1 LLGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPfSILHEMTGGYWLFGRDWCDVWHSFD 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 53933287 105 CLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRM 144
Cdd:cd15067  81 VLASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIM 120

7tmA_TRH-R

cd14995

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...

29-135

6.10e-04

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.

Pssm-ID: 320126 [Multi-domain] Cd Length: 269 Bit Score: 40.83 E-value: 6.10e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  29 VVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCC-SCAVTPKMLENFFSEDRIISLYE-CMAQFYFLCL 106
Cdd:cd14995   5 FLVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVlVAAGLPNEIESLLGPDSWIYGYAgCLLITYLQYL 84

                        90       100
                ....*....|....*....|....*....
gi 53933287 107 AETTDCFLLATMAYDRYVAICHPLQYHTM 135
Cdd:cd14995  85 GINASSLSITAFTIERYIAICHPMKAQFI 113

7tmA_Mel1

cd15209

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...

25-137

7.53e-04

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.

Pssm-ID: 320337 [Multi-domain] Cd Length: 279 Bit Score: 40.53 E-value: 7.53e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFL 104
Cdd:cd15209   1 SALACVLIVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIM 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 53933287 105 CLAETTDCFLLATMAYDRYVAICHPLQYHTMMS 137
Cdd:cd15209  81 GLSVIGSIFNITAIAINRYCYICHSLQYDRLYS 113

7tmA_PrRP_R

cd15394

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...

25-141

7.57e-04

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.

Pssm-ID: 320516 [Multi-domain] Cd Length: 286 Bit Score: 40.49 E-value: 7.57e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFsEDRIISLYECMAQFYFL 104
Cdd:cd15394   1 PLIIPLYSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAF-EPRGWVFGRFMCYFVFL 79

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 53933287 105 CLAETT--DCFLLATMAYDRYVAICHPLqyHTMMSKTLC 141
Cdd:cd15394  80 MQPVTVyvSVFTLTAIAVDRYYVTVYPL--RRRISRRTC 116

7tmA_PR4-like

cd15392

neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...

26-130

7.63e-04

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.

Pssm-ID: 320514 [Multi-domain] Cd Length: 287 Bit Score: 40.42 E-value: 7.63e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCavtpkMLENFFSEDRIISLY----ECMAQF 101
Cdd:cd15392   2 IIILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAV-----FCVPFSFIALLILQYwpfgEFMCPV 76

                        90       100       110
                ....*....|....*....|....*....|.
gi 53933287 102 --YFLCLAETTDCFLLATMAYDRYVAICHPL 130
Cdd:cd15392  77 vnYLQAVSVFVSAFTLVAISIDRYVAIMWPL 107

7tmA_V1aR

cd15385

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...

30-131

7.81e-04

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320507 [Multi-domain] Cd Length: 301 Bit Score: 40.57 E-value: 7.81e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  30 VFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSC-AVTPKMLEN----FFSED---RIISLYECMAQF 101
Cdd:cd15385   6 VLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFfQVLPQLCWDityrFYGPDflcRIVKHLQVLGMF 85

                        90       100       110
                ....*....|....*....|....*....|
gi 53933287 102 yflclaetTDCFLLATMAYDRYVAICHPLQ 131
Cdd:cd15385  86 --------ASTYMLVMMTADRYIAICHPLK 107

7tmA_MC2R_ACTH_R

cd15350

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...

29-137

9.73e-04

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320472 [Multi-domain] Cd Length: 270 Bit Score: 40.15 E-value: 9.73e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  29 VVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAvtpKMLENFFSEDRIISLYECMAQF------- 101
Cdd:cd15350   5 EVFFTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLY---KTLENILIILADMGYLNRRGPFetklddi 81

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 53933287 102 --YFLCLAETTDCFLLATMAYDRYVAICHPLQYHTMMS 137
Cdd:cd15350  82 mdSLFCLSLLGSIFSILAIAADRYITIFHALRYHNIMT 119

7tmA_QRFPR

cd15205

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...

25-146

1.23e-03

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.

Pssm-ID: 320333 [Multi-domain] Cd Length: 298 Bit Score: 40.15 E-value: 1.23e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFL 104
Cdd:cd15205   1 TAFVITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPFVQ 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 53933287 105 CLAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTT 146
Cdd:cd15205  81 STAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLG 122

7tmA_alpha1_AR

cd15062

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...

26-138

1.44e-03

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320190 [Multi-domain] Cd Length: 261 Bit Score: 39.78 E-value: 1.44e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPkmlenfFSedriiSLYECMAQFYF-- 103
Cdd:cd15062   2 VVGVALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLP------FS-----ATLEVLGYWAFgr 70

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 53933287 104 -LC--------LAETTDCFLLATMAYDRYVAICHPLQYHTMMSK 138
Cdd:cd15062  71 iFCdvwaavdvLCCTASIMSLCVISVDRYIGVRYPLNYPTIVTA 114

7tmA_Histamine_H1R

cd15050

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...

26-149

1.44e-03

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320178 [Multi-domain] Cd Length: 263 Bit Score: 39.72 E-value: 1.44e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15050   2 PLGIALSTISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDY 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAF 149
Cdd:cd15050  82 VASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAW 125

7tmA_Octopamine_R

cd15063

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...

26-138

1.64e-03

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.

Pssm-ID: 320191 [Multi-domain] Cd Length: 266 Bit Score: 39.40 E-value: 1.64e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYEC---MAQFY 102
Cdd:cd15063   2 ISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCqiwLAVDV 81

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 53933287 103 FLClaeTTDCFLLATMAYDRYVAICHPLQYHTMMSK 138
Cdd:cd15063  82 WMC---TASILNLCAISLDRYLAITRPIRYPSLMST 114

7tmA_AstC_insect

cd15094

somatostatin-like receptor for allatostatin C, member of the class A family of ...

29-130

2.02e-03

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.

Pssm-ID: 320222 [Multi-domain] Cd Length: 282 Bit Score: 39.38 E-value: 2.02e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  29 VVFSAIYLVTMVGNlGLV---ALIYVERRLLTPMYIFlgNLALMDSCCSCAVtPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15094   5 VLYGLICIVGLVGN-GLViyvVLRYAKMKTVTNLYIL--NLAVADECFLIGL-PFLIVTMILKYWPFGAAMCKIYMVLTS 80

                        90       100
                ....*....|....*....|....*
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPL 130
Cdd:cd15094  81 INQFTSSFTLTVMSADRYLAVCHPI 105

7tmA_MC1R

cd15351

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...

30-137

2.30e-03

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320473 [Multi-domain] Cd Length: 271 Bit Score: 39.01 E-value: 2.30e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  30 VFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFY------F 103
Cdd:cd15351   6 LFLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQHMdnvidtM 85

                        90       100       110
                ....*....|....*....|....*....|....
gi 53933287 104 LCLAETTDCFLLATMAYDRYVAICHPLQYHTMMS 137
Cdd:cd15351  86 ICSSVVSSLSFLGAIAVDRYITIFYALRYHSIMT 119

7tmA_AT1R

cd15192

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...

25-131

2.43e-03

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.

Pssm-ID: 320320 [Multi-domain] Cd Length: 285 Bit Score: 38.95 E-value: 2.43e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSC------CSCAVTPKMLENFFSEdriislYECM 98
Cdd:cd15192   1 IMIPTVYSIIFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCflitlpLWAAYTAMEYHWPFGN------FLCK 74

                        90       100       110
                ....*....|....*....|....*....|...
gi 53933287  99 AQFYFLCLAETTDCFLLATMAYDRYVAICHPLQ 131
Cdd:cd15192  75 IASALVSFNLYASVFLLTCLSIDRYLAIVHPMK 107

7tmA_5-HT7

cd15329

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...

26-132

2.43e-03

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320452 [Multi-domain] Cd Length: 260 Bit Score: 38.79 E-value: 2.43e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGN-LGLVALIYVeRRLLTPMYIFLGNLALMDSCCSCAVTPkmlenffsedrIISLYECMAQFYF- 103
Cdd:cd15329   2 LIGIVLLIIILGTVVGNaLVIIAVCLV-KKLRTPSNYLIVSLAVSDLLVALLVMP-----------LAIIYELSGYWPFg 69

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 53933287 104 --LCLAETTDCFLLAT--------MAYDRYVAICHPLQY 132
Cdd:cd15329  70 eiLCDVWISFDVLLCTasilnlcaISVDRYLVITRPLTY 108

7tmA_Mel1A

cd15402

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...

28-137

2.69e-03

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.

Pssm-ID: 320524 [Multi-domain] Cd Length: 279 Bit Score: 38.73 E-value: 2.69e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  28 FVVFSAIylVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLCLA 107
Cdd:cd15402   6 ILIFTIV--VDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQISGFLMGLS 83

                        90       100       110
                ....*....|....*....|....*....|
gi 53933287 108 ETTDCFLLATMAYDRYVAICHPLQYHTMMS 137
Cdd:cd15402  84 VIGSIFNITGIAINRYCYICHSLKYDKLYS 113

7tmA_Angiotensin_R-like

cd14985

angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...

29-130

2.80e-03

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.

Pssm-ID: 341320 [Multi-domain] Cd Length: 284 Bit Score: 38.90 E-value: 2.80e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  29 VVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDsCCSCAVTPKMLENFFSEDR-IISLYECMAQFYFLCLA 107
Cdd:cd14985   5 ALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAAD-LVFVLTLPLWATYTANQYDwPFGAFLCKVSSYVISVN 83

                        90       100
                ....*....|....*....|...
gi 53933287 108 ETTDCFLLATMAYDRYVAICHPL 130
Cdd:cd14985  84 MFASIFLLTCMSVDRYLAIVHPV 106

7tmA_Galanin_R-like

cd14971

galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...

29-130

3.94e-03

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.

Pssm-ID: 320102 [Multi-domain] Cd Length: 281 Bit Score: 38.22 E-value: 3.94e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  29 VVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLCLAE 108
Cdd:cd14971   5 LFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSM 84

                        90       100
                ....*....|....*....|..
gi 53933287 109 TTDCFLLATMAYDRYVAICHPL 130
Cdd:cd14971  85 HASIFTLVAMSLDRFLAVVYPL 106

7tmA_TAAR5-like

cd15317

trace amine-associated receptor 5 and similar receptors, member of the class A family of ...

25-137

4.52e-03

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320440 [Multi-domain] Cd Length: 290 Bit Score: 38.20 E-value: 4.52e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPkmlenfFSEDRIISL------YECM 98
Cdd:cd15317   1 VIIYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMP------FSMIRTVETcwyfgdLFCK 74

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 53933287  99 AQFYFLCLAETTDCFLLATMAYDRYVAICHPLQYHTMMS 137
Cdd:cd15317  75 FHTGLDLLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKIT 113

7tmA_5-HT6

cd15054

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...

33-162

4.80e-03

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320182 [Multi-domain] Cd Length: 267 Bit Score: 37.86 E-value: 4.80e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  33 AIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLCLAETTDC 112
Cdd:cd15054   9 LIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMCCSASI 88

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 53933287 113 FLLATMAYDRYVAICHPLQYHTMMSKTLCIRMTTGAFKAGNLHSMIHVGL 162
Cdd:cd15054  89 LNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLPIEL 138

7tmA_Beta3_AR

cd15959

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...

26-138

4.83e-03

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.

Pssm-ID: 320625 [Multi-domain] Cd Length: 302 Bit Score: 38.35 E-value: 4.83e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFLC 105
Cdd:cd15959   2 LAGALLSLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDV 81

                        90       100       110
                ....*....|....*....|....*....|...
gi 53933287 106 LAETTDCFLLATMAYDRYVAICHPLQYHTMMSK 138
Cdd:cd15959  82 LCVTASIETLCAIAVDRYLAITNPLRYEALVTK 114

7tmA_P2Y6

cd15379

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...

26-130

5.32e-03

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).

Pssm-ID: 320501 [Multi-domain] Cd Length: 288 Bit Score: 37.93 E-value: 5.32e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVtPKMLENFFSEDRI-ISLYEC-MAQFYF 103
Cdd:cd15379   2 LLPLVYSVVFLLGLPLNAVVIGQIWATRQALSRTTIYMLNLATADLLYVCSL-PLLIYNYTQKDYWpFGDFTCrLVRFQF 80

                        90       100
                ....*....|....*....|....*..
gi 53933287 104 LCLAETTDCFlLATMAYDRYVAICHPL 130
Cdd:cd15379  81 YTNLHGSILF-LTCISVQRYLGICHPL 106

7tmA_purinoceptor-like

cd14982

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...

25-134

6.02e-03

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341318 [Multi-domain] Cd Length: 283 Bit Score: 37.63 E-value: 6.02e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECMAQFYFL 104
Cdd:cd14982   1 TLFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLTGLLF 80

                        90       100       110
                ....*....|....*....|....*....|
gi 53933287 105 CLAETTDCFLLATMAYDRYVAICHPLQYHT 134
Cdd:cd14982  81 YINMYGSILFLTCISVDRYLAVVHPLKSRR 110

7tmA_Melanopsin-like

cd15083

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...

25-144

6.53e-03

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320211 [Multi-domain] Cd Length: 291 Bit Score: 37.70 E-value: 6.53e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  25 TLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPKMLENFFSEDRIISLYECmaQFYFL 104
Cdd:cd15083   1 YVLGIFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGC--DMYGF 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 53933287 105 C--LAETTDCFLLATMAYDRYVAICHPLQYHTMMSKTLCIRM 144
Cdd:cd15083  79 SggLFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIV 120

7tmA_KiSS1R

cd15095

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...

29-131

7.15e-03

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.

Pssm-ID: 320223 [Multi-domain] Cd Length: 288 Bit Score: 37.65 E-value: 7.15e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  29 VVFSAIYLVTMVGNLgLValIYV-----ERRLLTPMYIFlgNLALMD----SCCscavTPKMLENFFSEDRIISLYECMA 99
Cdd:cd15095   5 LIFAIIFLVGLAGNS-LV--IYVvsrhrEMRTVTNYYIV--NLAVTDlaflVCC----VPFTAALYATPSWVFGDFMCKF 75

                        90       100       110
                ....*....|....*....|....*....|..
gi 53933287 100 QFYFLCLAETTDCFLLATMAYDRYVAICHPLQ 131
Cdd:cd15095  76 VNYMMQVTVQATCLTLTALSVDRYYAIVHPIR 107

7tmA_TAAR2_3_4

cd15312

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...

27-137

7.32e-03

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320437 [Multi-domain] Cd Length: 289 Bit Score: 37.72 E-value: 7.32e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  27 LFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTP----KMLEN--FFSED--RIISLYECM 98
Cdd:cd15312   3 MYLFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPysmvRSVEScwYFGDLfcKIHSSLDMM 82

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 53933287  99 aqfyfLClaeTTDCFLLATMAYDRYVAICHPLQYHTMMS 137
Cdd:cd15312  83 -----LS---TTSIFHLCFIAVDRYYAVCDPLHYRTKIT 113

7tmA_NOFQ_opioid_R

cd15092

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...

29-131

7.33e-03

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.

Pssm-ID: 320220 [Multi-domain] Cd Length: 279 Bit Score: 37.54 E-value: 7.33e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  29 VVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVT---PKMLENFFSEDRIISLYECMAQFYFLc 105
Cdd:cd15092   5 VVYLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPfqgTDIFLGFWPFGNALCKTVIAIDYYNM- 83

                        90       100
                ....*....|....*....|....*.
gi 53933287 106 laeTTDCFLLATMAYDRYVAICHPLQ 131
Cdd:cd15092  84 ---FTSTFTLTAMSVDRYVAICHPIK 106

7tmA_5-HT1B_1D

cd15333

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...

23-132

8.76e-03

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320455 [Multi-domain] Cd Length: 265 Bit Score: 37.08 E-value: 8.76e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  23 LKTLLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTPkmLENFFSEDRIISLYECMAQFY 102
Cdd:cd15333   3 LKISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMP--ISIVYTVTGTWTLGQVVCDIW 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 53933287 103 FlcLAETTDC----FLLATMAYDRYVAICHPLQY 132
Cdd:cd15333  81 L--SSDITCCtasiLHLCVIALDRYWAITDAVEY 112

7tmA_Kappa_opioid_R

cd15091

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...

30-131

9.19e-03

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.

Pssm-ID: 320219 [Multi-domain] Cd Length: 282 Bit Score: 37.24 E-value: 9.19e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  30 VFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAV---TPKMLENFFSEDRIISLYECMAQFYFLcl 106
Cdd:cd15091   6 VYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMpfqSTVYLMNSWPFGDVLCKIVISIDYYNM-- 83

                        90       100
                ....*....|....*....|....*
gi 53933287 107 aeTTDCFLLATMAYDRYVAICHPLQ 131
Cdd:cd15091  84 --FTSIFTLTMMSVDRYIAVCHPVK 106

7tmA_tyramine_R-like

cd15061

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

26-144

9.62e-03

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320189 [Multi-domain] Cd Length: 256 Bit Score: 36.95 E-value: 9.62e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933287  26 LLFVVFSAIYLVTMVGNLGLVALIYVERRLLTPMYIFLGNLALMDSCCSCAVTP----KMLENFFSEDRIISLYECMAQF 101
Cdd:cd15061   1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPlaiiRQLLGYWPLGSHLCDFWISLDV 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 53933287 102 yFLCLAETTDcflLATMAYDRYVAICHPLQYHTMMSKTLCIRM 144
Cdd:cd15061  81 -LLCTASILN---LCCISLDRYFAITYPLKYRTKRSRRLAITM 119

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01