NCBI Conserved Domain Search

Conserved domains on [gi|153791876|ref|NP_001005186|]

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olfactory receptor 6Q1 [Homo sapiens]

Protein Classification

olfactory receptor( domain architecture ID 11599643)

olfactory receptor is a G-protein coupled receptor (GPCR) that plays a central role in olfaction, the sense of smell; GPCRs transmit physiological signals from the outside of the cell to the inside via G proteins by binding to an extracellular agonist, which induces conformational changes that lead to the activation of heterotrimeric G proteins, which then bind to and activate numerous downstream effector proteins

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

27-298

6.55e-149

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 418.81 E-value: 6.55e-149

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvdGGKNISYADCLSQLF 106
Cdd:cd13954    1 ILLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLS--GDKTISFSGCLTQLY 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDAS 186
Cdd:cd13954   79 FFFSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 187 PLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQT 266
Cdd:cd13954  159 PLLKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRP 238

                        250       260       270
                 ....*....|....*....|....*....|..
gi 153791876 267 KVTSSINFNKVVSVFYSVVTPMLNPLIYSLRN 298
Cdd:cd13954  239 SSSYSSDLDKVVSVFYTVVTPMLNPIIYSLRN 270

Name

Accession

Description

Interval

E-value

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

27-298

6.55e-149

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 418.81 E-value: 6.55e-149

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvdGGKNISYADCLSQLF 106
Cdd:cd13954    1 ILLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLS--GDKTISFSGCLTQLY 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDAS 186
Cdd:cd13954   79 FFFSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 187 PLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQT 266
Cdd:cd13954  159 PLLKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRP 238

                        250       260       270
                 ....*....|....*....|....*....|..
gi 153791876 267 KVTSSINFNKVVSVFYSVVTPMLNPLIYSLRN 298
Cdd:cd13954  239 SSSYSSDLDKVVSVFYTVVTPMLNPIIYSLRN 270

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

33-310

7.22e-42

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 146.11 E-value: 7.22e-42

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876   33 FLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvdGGKNISYADCLSQLFIFTFLG 112
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWF--GLREISFEACLTQMFFIHKFS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  113 ATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDASPLLALS 192
Cdd:pfam13853  79 IMESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  193 CSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQTKVTSSI 272
Cdd:pfam13853 159 CADIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNV 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 153791876  273 N--FNKVVSVFYSVVTPMLNPLIYSLRNKEVKGALGRVFS 310
Cdd:pfam13853 239 PplLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRMLL 278

Name

Accession

Description

Interval

E-value

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

27-298

6.55e-149

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 418.81 E-value: 6.55e-149

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvdGGKNISYADCLSQLF 106
Cdd:cd13954    1 ILLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLS--GDKTISFSGCLTQLY 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDAS 186
Cdd:cd13954   79 FFFSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 187 PLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQT 266
Cdd:cd13954  159 PLLKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRP 238

                        250       260       270
                 ....*....|....*....|....*....|..
gi 153791876 267 KVTSSINFNKVVSVFYSVVTPMLNPLIYSLRN 298
Cdd:cd13954  239 SSSYSSDLDKVVSVFYTVVTPMLNPIIYSLRN 270

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

27-305

1.06e-130

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 372.94 E-value: 1.06e-130

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvdGGKNISYADCLSQLF 106
Cdd:cd15225    1 LLLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLS--EDKTISFLGCATQMF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDAS 186
Cdd:cd15225   79 FFLFLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 187 PLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQT 266
Cdd:cd15225  159 PVLKLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRP 238

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 153791876 267 KVTSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGAL 305
Cdd:cd15225  239 KSSYSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

27-298

8.58e-129

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 367.97 E-value: 8.58e-129

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvdGGKNISYADCLSQLF 106
Cdd:cd15912    1 ILLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLS--GKKTISFAGCFAQSF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDAS 186
Cdd:cd15912   79 FYFFLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 187 PLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQT 266
Cdd:cd15912  159 PLLKLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRP 238

                        250       260       270
                 ....*....|....*....|....*....|..
gi 153791876 267 KVTSSINFNKVVSVFYSVVTPMLNPLIYSLRN 298
Cdd:cd15912  239 SQSSSLDLNKVVALLNTVVTPLLNPFIYTLRN 270

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

27-298

6.24e-127

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 363.34 E-value: 6.24e-127

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvdGGKNISYADCLSQLF 106
Cdd:cd15911    1 ILLFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLT--GDRTISVSGCIVQFY 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDAS 186
Cdd:cd15911   79 FFGSLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 187 PLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQT 266
Cdd:cd15911  159 PLLKLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVP 238

                        250       260       270
                 ....*....|....*....|....*....|..
gi 153791876 267 KVTSSINFNKVVSVFYSVVTPMLNPLIYSLRN 298
Cdd:cd15911  239 STNTSRDLNKVFSLFYTVLTPLVNPLIYSLRN 270

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

28-298

2.65e-124

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 356.43 E-value: 2.65e-124

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  28 LFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFigVDGGKNISYADCLSQLFI 107
Cdd:cd15230    2 PLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNF--LSEKKTISFAGCAAQFFF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 108 FTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDASP 187
Cdd:cd15230   80 FAVFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 188 LLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQTK 267
Cdd:cd15230  160 LLKLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPS 239

                        250       260       270
                 ....*....|....*....|....*....|.
gi 153791876 268 VTSSINFNKVVSVFYSVVTPMLNPLIYSLRN 298
Cdd:cd15230  240 SSYSLDQDKVVSVFYTVVIPMLNPLIYSLRN 270

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

27-298

6.56e-124

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 355.82 E-value: 6.56e-124

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGVDggKNISYADCLSQLF 106
Cdd:cd15224    1 LLLFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQN--KSISFVGCMTQLY 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDAS 186
Cdd:cd15224   79 FFLSLACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDIS 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 187 PLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQT 266
Cdd:cd15224  159 PLLNLSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARP 238

                        250       260       270
                 ....*....|....*....|....*....|..
gi 153791876 267 KVTSSINFNKVVSVFYSVVTPMLNPLIYSLRN 298
Cdd:cd15224  239 KAISSFDSNKLVSVLYTVVTPLLNPIIYCLRN 270

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

27-307

2.82e-114

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 331.53 E-value: 2.82e-114

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIgvDGGKNISYADCLSQLF 106
Cdd:cd15417    1 IILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFF--REQKTISFVGCATQYF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDAS 186
Cdd:cd15417   79 VFSGMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 187 PLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQT 266
Cdd:cd15417  159 PLLSLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRP 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 153791876 267 KVTSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGALGR 307
Cdd:cd15417  239 SSSHSQDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

27-305

6.02e-113

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 328.07 E-value: 6.02e-113

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvdGGKNISYADCLSQLF 106
Cdd:cd15231    1 LLLFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLR--ERKTISYIGCLAQLF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDAS 186
Cdd:cd15231   79 FFVSFVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 187 PLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQT 266
Cdd:cd15231  159 PLLKLSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRP 238

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 153791876 267 KVTSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGAL 305
Cdd:cd15231  239 SSGYSLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

14-302

6.77e-112

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 325.81 E-value: 6.77e-112

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  14 FVMMGFAGIHEAHLLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFigVDGG 93
Cdd:cd15408    1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNL--LAER 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  94 KNISYADCLSQLFIFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFY 173
Cdd:cd15408   79 KVISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFC 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 174 GPNVIDHFSCDASPLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVS 253
Cdd:cd15408  159 GSNVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVT 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 153791876 254 LFYGTLFFMYVQTKVTSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVK 302
Cdd:cd15408  239 LFYGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

28-305

5.34e-111

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 323.02 E-value: 5.34e-111

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  28 LFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFigVDGGKNISYADCLSQLFI 107
Cdd:cd15235    3 LLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANL--LSGSKTISYAGCLAQMYF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 108 FTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDASP 187
Cdd:cd15235   81 FIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 188 LLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQTK 267
Cdd:cd15235  161 LLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPS 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 153791876 268 VTSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGAL 305
Cdd:cd15235  241 SSYSADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

28-305

8.59e-111

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 322.62 E-value: 8.59e-111

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  28 LFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGVDggKNISYADCLSQLFI 107
Cdd:cd15229    2 FLFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSER--KTISVEGCIAQIFF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 108 FTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDASP 187
Cdd:cd15229   80 FFFFAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 188 LLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQTK 267
Cdd:cd15229  160 LLPLSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPN 239

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 153791876 268 VTSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGAL 305
Cdd:cd15229  240 SASSSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

29-307

4.21e-109

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 318.49 E-value: 4.21e-109

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  29 FFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvdGGKNISYADCLSQLFIF 108
Cdd:cd15411    3 LFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLS--GRKAISFAGCFVQMYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 109 TFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDASPL 188
Cdd:cd15411   81 IALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 189 LALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQTKV 268
Cdd:cd15411  161 LKLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSS 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 153791876 269 TSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGALGR 307
Cdd:cd15411  241 SYSLGQDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

28-298

6.22e-108

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 314.93 E-value: 6.22e-108

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  28 LFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvdGGKNISYADCLSQLFI 107
Cdd:cd15431    2 ILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLS--DRPTISYSRCLAQMYI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 108 FTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLsQLTFYGPNVIDHFSCDASP 187
Cdd:cd15431   80 SLFLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPVLTM-PLHFCGPNVINHFFCEVQA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 188 LLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQTK 267
Cdd:cd15431  159 LLKLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQ 238

                        250       260       270
                 ....*....|....*....|....*....|.
gi 153791876 268 VTSSINFNKVVSVFYSVVTPMLNPLIYSLRN 298
Cdd:cd15431  239 SKSSSDQDKIISVFYGVVTPMLNPLIYSLRN 269

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

13-309

7.89e-108

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 315.84 E-value: 7.89e-108

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  13 EFVMMGFAGIHEAHLLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvdG 92
Cdd:cd15943    1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLA--E 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  93 GKNISYADCLSQLFIFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTF 172
Cdd:cd15943   79 NKTISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPF 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 173 YGPNVIDHFSCDASPLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVV 252
Cdd:cd15943  159 CGSNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAV 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 153791876 253 SLFYGTLFFMYVQTKVTSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGALGRVF 309
Cdd:cd15943  239 TIFYGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

14-309

1.45e-107

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 314.98 E-value: 1.45e-107

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  14 FVMMGFAGIHEAHLLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGVDgg 93
Cdd:cd15410    1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAED-- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  94 KNISYADCLSQLFIFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFY 173
Cdd:cd15410   79 KAISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFC 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 174 GPNVIDHFSCDASPLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVS 253
Cdd:cd15410  159 GSNVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAIT 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 153791876 254 LFYGTLFFMYVQTKVTSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGALGRVF 309
Cdd:cd15410  239 IFHGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

27-298

2.96e-107

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 313.44 E-value: 2.96e-107

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGVDggKNISYADCLSQLF 106
Cdd:cd15237    1 ILLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEH--KTISFVGCAAQMF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDAS 186
Cdd:cd15237   79 FFLALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 187 PLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQT 266
Cdd:cd15237  159 AVLKLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRP 238

                        250       260       270
                 ....*....|....*....|....*....|..
gi 153791876 267 KVTSSINFNKVVSVFYSVVTPMLNPLIYSLRN 298
Cdd:cd15237  239 HSTHSPDQDKMISVFYTIVTPMLNPLIYSLRN 270

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

27-305

3.30e-107

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 313.57 E-value: 3.30e-107

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFigVDGGKNISYADCLSQLF 106
Cdd:cd15412    1 PLLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNF--LSEKKTISFAGCFTQCY 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDAS 186
Cdd:cd15412   79 FFIALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 187 PLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQT 266
Cdd:cd15412  159 PLIKLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRP 238

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 153791876 267 KVTSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGAL 305
Cdd:cd15412  239 PSEESVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQAL 277

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

27-307

3.76e-106

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 310.78 E-value: 3.76e-106

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIgvDGGKNISYADCLSQLF 106
Cdd:cd15419    1 VLLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFL--SESKTISYNGCAAQFF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDAS 186
Cdd:cd15419   79 FFSLFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 187 PLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQT 266
Cdd:cd15419  159 PLLKLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQP 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 153791876 267 KVTSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGALGR 307
Cdd:cd15419  239 GAVSSPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

27-298

4.25e-106

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 310.54 E-value: 4.25e-106

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAgfIGVDGGKNISYADCLSQLF 106
Cdd:cd15227    1 ILHFVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIA--NSLTNTRSISFLGCVAQVF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDAS 186
Cdd:cd15227   79 LFIFFAASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 187 PLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQT 266
Cdd:cd15227  159 QLLKLSCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKP 238

                        250       260       270
                 ....*....|....*....|....*....|..
gi 153791876 267 KVTSSINFNKVVSVFYSVVTPMLNPLIYSLRN 298
Cdd:cd15227  239 PSDSPSLLDLLLSVFYSVVPPTLNPIIYSLRN 270

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

28-298

9.61e-105

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 306.85 E-value: 9.61e-105

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  28 LFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIgvDGGKNISYADCLSQLFI 107
Cdd:cd15918    2 LLFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQ--TQSKSISYAGCLTQMYF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 108 FTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDASP 187
Cdd:cd15918   80 FLLFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 188 LLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQTK 267
Cdd:cd15918  160 LLKLSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPP 239

                        250       260       270
                 ....*....|....*....|....*....|.
gi 153791876 268 VTSSINFNKVVSVFYSVVTPMLNPLIYSLRN 298
Cdd:cd15918  240 SSHSASKDSVAAVMYTVVTPMLNPFIYSLRN 270

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

30-305

7.78e-104

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 305.09 E-value: 7.78e-104

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  30 FILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGVDggKNISYADCLSQLFIFT 109
Cdd:cd15429    4 FVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEH--KTISFASCVAQLFISL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 110 FLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDASPLL 189
Cdd:cd15429   82 ALGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 190 ALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQTKVT 269
Cdd:cd15429  162 RLACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSG 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 153791876 270 SSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGAL 305
Cdd:cd15429  242 SSALQEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

27-307

4.99e-103

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 303.13 E-value: 4.99e-103

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIgvDGGKNISYADCLSQLF 106
Cdd:cd15416    1 IILFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFL--VEKTTISYPGCAAQLC 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDAS 186
Cdd:cd15416   79 SAATFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 187 PLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQT 266
Cdd:cd15416  159 PLLKLSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMP 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 153791876 267 KVTSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGALGR 307
Cdd:cd15416  239 NSSYSMDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

27-309

5.92e-103

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 303.19 E-value: 5.92e-103

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvdGGKNISYADCLSQLF 106
Cdd:cd15414    1 IPLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFV--EKKAISFLGCAAQMW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDAS 186
Cdd:cd15414   79 FFGLFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 187 PLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQT 266
Cdd:cd15414  159 PLLSLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRP 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 153791876 267 KVTSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGALGRVF 309
Cdd:cd15414  239 SSSSSLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTI 281

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

27-305

1.05e-101

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 299.47 E-value: 1.05e-101

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFigVDGGKNISYADCLSQLF 106
Cdd:cd15421    1 LFLFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNF--LSGRKSISFVGCGTQIF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTP-ILPIYLLSqLTFYGPNVIDHFSCDA 185
Cdd:cd15421   79 FFLTLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSlIHTVYTMH-FPYCGSREIHHFFCEV 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 186 SPLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQ 265
Cdd:cd15421  158 PALLKLSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMR 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 153791876 266 TKVTSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGAL 305
Cdd:cd15421  238 PGSYHSPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

29-307

2.26e-101

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 298.85 E-value: 2.26e-101

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  29 FFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFigVDGGKNISYADCLSQLFIF 108
Cdd:cd15413    3 LFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNF--VVEQNTISFYACATQLAFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 109 TFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDASPL 188
Cdd:cd15413   81 LTFIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 189 LALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQTKV 268
Cdd:cd15413  161 LALSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKS 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 153791876 269 TSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGALGR 307
Cdd:cd15413  241 SHSLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

27-298

3.62e-100

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 295.43 E-value: 3.62e-100

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIgvDGGKNISYADCLSQLF 106
Cdd:cd15914    1 LLLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLL--SEEKTISFNGCLLQMY 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDAS 186
Cdd:cd15914   79 FFHSLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 187 PLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQT 266
Cdd:cd15914  159 PLLSLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRL 238

                        250       260       270
                 ....*....|....*....|....*....|..
gi 153791876 267 KVTSSINFNKVVSVFYSVVTPMLNPLIYSLRN 298
Cdd:cd15914  239 SKSYSLDYDRAIAVVYAVLTPFFNPIIYSLRN 270

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

27-305

1.29e-99

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 294.23 E-value: 1.29e-99

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFigVDGGKNISYADCLSQLF 106
Cdd:cd15420    1 LLLFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNL--LKQRKTISFAGCGTQMY 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDAS 186
Cdd:cd15420   79 LFLALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEIL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 187 PLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQT 266
Cdd:cd15420  159 AVLKLACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVP 238

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 153791876 267 KVTSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGAL 305
Cdd:cd15420  239 GSSNSAEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

28-307

2.53e-99

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 293.54 E-value: 2.53e-99

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  28 LFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvdGGKNISYADCLSQLFI 107
Cdd:cd15409    2 PLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLS--KNKMISFSGCAAQFFF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 108 FTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDASP 187
Cdd:cd15409   80 FGFSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 188 LLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQTK 267
Cdd:cd15409  160 LLKISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPS 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 153791876 268 VTSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGALGR 307
Cdd:cd15409  240 SLYALDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

27-298

7.46e-99

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 291.91 E-value: 7.46e-99

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFigVDGGKNISYADCLSQLF 106
Cdd:cd15913    1 ILLFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNF--LSETKTISFSGCFLQFY 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDAS 186
Cdd:cd15913   79 FFFSLGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 187 PLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQT 266
Cdd:cd15913  159 PLLALSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSP 238

                        250       260       270
                 ....*....|....*....|....*....|..
gi 153791876 267 KVTSSINFNKVVSVFYSVVTPMLNPLIYSLRN 298
Cdd:cd15913  239 GSGNSTGMQKIVTLFYSVVTPLLNPLIYSLRN 270

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

27-298

1.92e-97

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 288.37 E-value: 1.92e-97

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGVDggKNISYADCLSQLF 106
Cdd:cd15947    1 MPLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPD--KTISYGGCVTQLY 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDAS 186
Cdd:cd15947   79 IFLWLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 187 PLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQT 266
Cdd:cd15947  159 ALIKLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQP 238

                        250       260       270
                 ....*....|....*....|....*....|..
gi 153791876 267 KVTSSINFNKVVSVFYSVVTPMLNPLIYSLRN 298
Cdd:cd15947  239 PSSYSQDQGKFISLFYTVVTPTLNPLIYTLRN 270

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

27-298

8.35e-92

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 274.25 E-value: 8.35e-92

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIgvDGGKNISYADCLSQLF 106
Cdd:cd15430    1 ILLFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFL--SERKTISFSGCAVQMY 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDAS 186
Cdd:cd15430   79 LSLAMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEIL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 187 PLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQT 266
Cdd:cd15430  159 AVLKLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKP 238

                        250       260       270
                 ....*....|....*....|....*....|..
gi 153791876 267 KVTSSINFNKVVSVFYSVVTPMLNPLIYSLRN 298
Cdd:cd15430  239 KSKNAQISDKLITLFYGVVTPMLNPIIYSLRN 270

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

24-308

1.58e-91

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 274.25 E-value: 1.58e-91

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  24 EAHLLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvdgGKN-ISYADCL 102
Cdd:cd15406    7 ELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVS---EKNiISYPECM 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 103 SQLFIFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFS 182
Cdd:cd15406   84 TQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVINHYF 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 183 CDASPLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFM 262
Cdd:cd15406  164 CDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSIIFM 243

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 153791876 263 YVQTKVTSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGALGRV 308
Cdd:cd15406  244 YLKPSSSSSMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKV 289

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

29-305

1.83e-91

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 273.53 E-value: 1.83e-91

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  29 FFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIgvDGGKNISYADCLSQLFIF 108
Cdd:cd15407    3 LFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLL--TGDKVISYNACAAQMFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 109 TFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDASPL 188
Cdd:cd15407   81 VVFATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 189 LALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQTKV 268
Cdd:cd15407  161 LALSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSS 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 153791876 269 TSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGAL 305
Cdd:cd15407  241 SHSMDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAF 277

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

27-298

8.15e-91

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 271.44 E-value: 8.15e-91

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFigVDGGKNISYADCLSQLF 106
Cdd:cd15232    1 VLLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNL--LTERKTISFGGCMAQLY 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDAS 186
Cdd:cd15232   79 FFTWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 187 PLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQT 266
Cdd:cd15232  159 PLLLLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRP 238

                        250       260       270
                 ....*....|....*....|....*....|..
gi 153791876 267 KVTSSINFNKVVSVFYSVVTPMLNPLIYSLRN 298
Cdd:cd15232  239 SSSYSPEKDKVVAVLYSVVTPTLNPLIYSLRN 270

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

28-305

1.66e-90

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 271.18 E-value: 1.66e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  28 LFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGVDggKNISYADCLSQLFI 107
Cdd:cd15434    2 ILSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPD--KTISYVGCAIQLFI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 108 FTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDASP 187
Cdd:cd15434   80 ALGLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 188 LLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQTK 267
Cdd:cd15434  160 LIKLACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPK 239

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 153791876 268 VTSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGAL 305
Cdd:cd15434  240 NSVSQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

27-305

1.91e-90

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 270.84 E-value: 1.91e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvdGGKNISYADCLSQLF 106
Cdd:cd15424    1 ILLFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLA--GNGAISFARCTTQMY 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDAS 186
Cdd:cd15424   79 IALSLGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 187 PLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQT 266
Cdd:cd15424  159 VVLKLACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRP 238

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 153791876 267 KVTSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGAL 305
Cdd:cd15424  239 RSGSTPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

27-305

2.04e-90

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 270.89 E-value: 2.04e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGVDggKNISYADCLSQLF 106
Cdd:cd15432    1 MVLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQ--KTISYGGCVAQLF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDAS 186
Cdd:cd15432   79 IFLGLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 187 PLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQT 266
Cdd:cd15432  159 ALLKLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQP 238

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 153791876 267 KVTSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGAL 305
Cdd:cd15432  239 PSNSSHDRGKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

29-298

2.24e-90

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 270.72 E-value: 2.24e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  29 FFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFigVDGGKNISYADCLSQLFIF 108
Cdd:cd15915    3 LFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGL--LSEHKTISFQGCISQLHFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 109 TFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDASPL 188
Cdd:cd15915   81 HFLGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 189 LALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHI-RSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQTK 267
Cdd:cd15915  161 LKLACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLLLKvRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPS 240

                        250       260       270
                 ....*....|....*....|....*....|.
gi 153791876 268 VTSSINFNKVVSVFYSVVTPMLNPLIYSLRN 298
Cdd:cd15915  241 SGDSLEQDRIVALLYTVVTPVLNPLIYTLRN 271

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

14-307

2.69e-90

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 271.23 E-value: 2.69e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  14 FVMMGFAGIHEAHLLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvdGG 93
Cdd:cd15945    1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLA--KR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  94 KNISYADCLSQLFIFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFY 173
Cdd:cd15945   79 KSIPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFC 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 174 GPNVIDHFSCDASPLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVS 253
Cdd:cd15945  159 GSNTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVG 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 153791876 254 LFYGTLFFMYVQTKVTSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGALGR 307
Cdd:cd15945  239 LFYGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

28-305

7.96e-89

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 266.62 E-value: 7.96e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  28 LFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIgVDGGKNISYADCLSQLFI 107
Cdd:cd15916    2 LLFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFL-EPGGKVISFGGCVAQLYF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 108 FTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDASP 187
Cdd:cd15916   81 FHFLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 188 LLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQTK 267
Cdd:cd15916  161 LLKLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPG 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 153791876 268 vtSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGAL 305
Cdd:cd15916  241 --SKEALDGVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

28-298

3.28e-88

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 264.85 E-value: 3.28e-88

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  28 LFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvdGGKNISYADCLSQLFI 107
Cdd:cd15939    2 ICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLS--ERKTISFNGCMTQLFA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 108 FTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDASP 187
Cdd:cd15939   80 EHFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 188 LLALSCSD-------VTWKETVDFLVSLAVLLASSMVIAVSygnivwtlLHIRSAAERWKAFSTCAAHLTVVSLFYGTLF 260
Cdd:cd15939  160 LLKLACTDtyvigllVVANSGLICLLSFLILLISYIVILYS--------LRTHSSEGRRKALSTCGSHITVVVLFFVPCI 231

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 153791876 261 FMYVQTKVTSSInfNKVVSVFYSVVTPMLNPLIYSLRN 298
Cdd:cd15939  232 FIYMRPVTTFPI--DKVVAVFYTIITPMLNPLIYTLRN 267

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

28-305

7.77e-88

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 264.44 E-value: 7.77e-88

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  28 LFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGVDggKNISYADCLSQLFI 107
Cdd:cd15234    2 LLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQS--KSISYTGCLTQMCF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 108 FTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDASP 187
Cdd:cd15234   80 FLLFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQ 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 188 LLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQTK 267
Cdd:cd15234  160 VLKLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSA 239

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 153791876 268 VTSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGAL 305
Cdd:cd15234  240 VTHSSRKTAVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

30-307

9.03e-88

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 264.28 E-value: 9.03e-88

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  30 FILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGVDggKNISYADCLSQLFIFT 109
Cdd:cd15415    4 FMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEK--KTISYSACIAQHFFFA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 110 FLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDASPLL 189
Cdd:cd15415   82 VFVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 190 ALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQTKVT 269
Cdd:cd15415  162 KLSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQ 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 153791876 270 SSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGALGR 307
Cdd:cd15415  242 YSLEQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

27-308

4.24e-87

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 262.41 E-value: 4.24e-87

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGVDggKNISYADCLSQLF 106
Cdd:cd15418    2 LILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKD--KSISFAGCAAQFF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDAS 186
Cdd:cd15418   80 FSAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 187 PLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQT 266
Cdd:cd15418  160 PLVKLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRP 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 153791876 267 KVTSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGALGRV 308
Cdd:cd15418  240 SSSHTPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

14-309

3.36e-86

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 260.87 E-value: 3.36e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  14 FVMMGFAGIHEAHLLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFigVDGG 93
Cdd:cd15944    1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADF--LTKH 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  94 KNISYADCLSQLFIFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFY 173
Cdd:cd15944   79 KVISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFC 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 174 GPNVIDHFSCDASPLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVS 253
Cdd:cd15944  159 GSNIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVT 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 153791876 254 LFYGTLFFMYVQTKVTSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGALGRVF 309
Cdd:cd15944  239 LFYGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

28-305

5.78e-85

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 257.00 E-value: 5.78e-85

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  28 LFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGVDggKNISYADCLSQLFI 107
Cdd:cd15236    2 VFFALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQD--QSIPYAGCISQMYF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 108 FTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDASP 187
Cdd:cd15236   80 FIFFGCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 188 LLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQTK 267
Cdd:cd15236  160 LLKLSCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPS 239

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 153791876 268 VTSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGAL 305
Cdd:cd15236  240 SNNSSDKDIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

28-305

1.96e-84

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 255.49 E-value: 1.96e-84

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  28 LFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGVDggKNISYADCLSQLFI 107
Cdd:cd15233    2 VLFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHK--RTISYAACLSQLFF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 108 FTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDASP 187
Cdd:cd15233   80 FHLLAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 188 LLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQTK 267
Cdd:cd15233  160 LFQLSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLG 239

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 153791876 268 VTSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGAL 305
Cdd:cd15233  240 SVYSSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

27-305

1.89e-83

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 253.17 E-value: 1.89e-83

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGVDggKNISYADCLSQLF 106
Cdd:cd15428    1 ILLFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSER--KIISFIRCAAQLY 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDAS 186
Cdd:cd15428   79 FFLSFGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 187 PLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQT 266
Cdd:cd15428  159 ALLKLASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRP 238

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 153791876 267 KVTSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGAL 305
Cdd:cd15428  239 KSSTSKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

28-305

5.49e-83

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 251.97 E-value: 5.49e-83

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  28 LFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGVDggKNISYADCLSQLFI 107
Cdd:cd15228    2 ILFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQS--RVISLGGCMSQVFF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 108 FTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDASP 187
Cdd:cd15228   80 YHFLGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 188 LLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQTk 267
Cdd:cd15228  160 VLKLACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQP- 238

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 153791876 268 vTSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGAL 305
Cdd:cd15228  239 -TPSPVLVTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

27-298

1.24e-82

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 250.58 E-value: 1.24e-82

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIgvDGGKNISYADCLSQLF 106
Cdd:cd15226    1 LFLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLL--REHKTISFGGCMAQIF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDAS 186
Cdd:cd15226   79 FLHFFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 187 PLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHiRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQT 266
Cdd:cd15226  159 LVIKLACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRK-HSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWP 237

                        250       260       270
                 ....*....|....*....|....*....|..
gi 153791876 267 kvTSSINFNKVVSVFYSVVTPMLNPLIYSLRN 298
Cdd:cd15226  238 --FSTFPVDKFLAVFYTVITPLLNPIIYTLRN 267

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

27-298

6.82e-80

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 243.89 E-value: 6.82e-80

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIgvDGGKNISYADCLSQLF 106
Cdd:cd15940    1 LAFFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLL--SEEKTISFNGCVTQLF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDAS 186
Cdd:cd15940   79 FLHLFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 187 PLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHiRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYvqT 266
Cdd:cd15940  159 PVIKLACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRK-RSTEGRRKALSTCASHLTVVTLFFGPCIFIY--T 235

                        250       260       270
                 ....*....|....*....|....*....|..
gi 153791876 267 KVTSSINFNKVVSVFYSVVTPMLNPLIYSLRN 298
Cdd:cd15940  236 RPSTSFSEDKVVSVFYTVVTPLLNPIIYTLRN 267

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

27-305

9.15e-80

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 243.86 E-value: 9.15e-80

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvdgGKN-ISYADCLSQL 105
Cdd:cd15405    1 IPLFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVS---EKNtISYAGCMTQL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 106 FIFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDA 185
Cdd:cd15405   78 FFFCFFVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDI 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 186 SPLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQ 265
Cdd:cd15405  158 LPLLQLSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLK 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 153791876 266 TKVTSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGAL 305
Cdd:cd15405  238 PSSVGSVNQGKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

27-298

4.44e-78

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 239.30 E-value: 4.44e-78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvdGGKNISYADCLSQLF 106
Cdd:cd15946    1 SILFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLS--HKKTISFTGCVAQMY 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDAS 186
Cdd:cd15946   79 IFLALGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 187 PLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQT 266
Cdd:cd15946  159 AVLKLACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRP 238

                        250       260       270
                 ....*....|....*....|....*....|..
gi 153791876 267 KVTSSINFNKVVSVFYSVVTPMLNPLIYSLRN 298
Cdd:cd15946  239 GSNYSPERDKKISLFYNVFTALLNPVIYSLRN 270

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

27-305

6.80e-77

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 236.28 E-value: 6.80e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRR-PMYFFLTHLSCLEIWYTSVTVPKMLAGFIGVDGgKNISYADCLSQL 105
Cdd:cd15941    1 SLFFLLFLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSG-RTISFEGCVVQL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 106 FIFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDA 185
Cdd:cd15941   80 YAFHFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 186 SPLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQ 265
Cdd:cd15941  160 PPVLKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQ 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 153791876 266 TKvtSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGAL 305
Cdd:cd15941  240 PS--SSQAGAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

27-298

6.03e-76

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 233.77 E-value: 6.03e-76

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIgvDGGKNISYADCLSQLF 106
Cdd:cd15936    1 FFLFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLL--SQTKTISFNGCMAQMF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDAS 186
Cdd:cd15936   79 FFHFTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 187 PLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYgNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQT 266
Cdd:cd15936  159 QVIKLACTDTFLLELLMVSNSGLVTLLIFFILLISY-TVILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARP 237

                        250       260       270
                 ....*....|....*....|....*....|..
gi 153791876 267 KVTSSInfNKVVSVFYSVVTPMLNPLIYSLRN 298
Cdd:cd15936  238 FQTFPM--DKAVSVLYTVITPMLNPMIYTLRN 267

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

30-305

6.94e-76

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 233.86 E-value: 6.94e-76

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  30 FILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIgvDGGKNISYADCLSQLFIFT 109
Cdd:cd15942    4 FLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFL--SGGRIISFGGCVTQLFFFH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 110 FLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDASPLL 189
Cdd:cd15942   82 FLGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAML 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 190 ALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQTKVT 269
Cdd:cd15942  162 KLACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQ 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 153791876 270 SSInfNKVVSVFYSVVTPMLNPLIYSLRNKEVKGAL 305
Cdd:cd15942  242 DPL--DGVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

28-305

5.91e-75

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 231.60 E-value: 5.91e-75

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  28 LFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGVDggKNISYADCLSQLFI 107
Cdd:cd15433    2 VLFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPA--LTITRGGCVAQLFI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 108 FTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDASP 187
Cdd:cd15433   80 SLALGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 188 LLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQTK 267
Cdd:cd15433  160 FLKLACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPI 239

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 153791876 268 VTSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGAL 305
Cdd:cd15433  240 HRYSQAHGKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

28-298

3.52e-70

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 218.97 E-value: 3.52e-70

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  28 LFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGVDggKNISYADCLSQLFI 107
Cdd:cd15938    2 LLFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQR--KAISYEACIAQLFF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 108 FTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDASP 187
Cdd:cd15938   80 LHFVGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 188 LLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIvwtLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQTK 267
Cdd:cd15938  160 VIKLACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTI---LVTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPF 236

                        250       260       270
                 ....*....|....*....|....*....|.
gi 153791876 268 VTSSInfNKVVSVFYSVVTPMLNPLIYSLRN 298
Cdd:cd15938  237 STFPV--DKHVSVLYNVITPMLNPLIYTLRN 265

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

27-298

1.11e-68

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 215.01 E-value: 1.11e-68

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRR-PMYFFLTHLSCLEIWYTSVTVPKMLAGFigVDGGKNISYADCLSQL 105
Cdd:cd15935    1 LLLFVLVLACYAAILLGNLLIVVTVHADPHLLQsPMYFFLANLSLIDMTLGSVAVPKVLADL--LTCGRTISFGGCMAQL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 106 FIFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDA 185
Cdd:cd15935   79 FFLHFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDV 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 186 SPLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTlLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVq 265
Cdd:cd15935  159 PQVIKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTT-LRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYL- 236

                        250       260       270
                 ....*....|....*....|....*....|...
gi 153791876 266 tKVTSSINFNKVVSVFYSVVTPMLNPLIYSLRN 298
Cdd:cd15935  237 -RPFSSSSVDKVASVFYTLITPALNPLIYTLRN 268

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

27-298

1.04e-65

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 207.28 E-value: 1.04e-65

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIgvDGGKNISYADCLSQLF 106
Cdd:cd15937    1 LLLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFF--SERKTISYGGCMAQLF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDAS 186
Cdd:cd15937   79 FLHFLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDIT 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 187 PLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVwTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQT 266
Cdd:cd15937  159 QVIKLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLL-AKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARP 237

                        250       260       270
                 ....*....|....*....|....*....|..
gi 153791876 267 kvTSSINFNKVVSVFYSVVTPMLNPLIYSLRN 298
Cdd:cd15937  238 --FRSFPMDKVVAVFHTVIFPLLNPMIYTLRN 267

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

28-305

3.14e-60

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 193.66 E-value: 3.14e-60

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  28 LFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvdGGKNISYADCLSQLFI 107
Cdd:cd15223    2 WLSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWF--DANTISLPGCFAQMFF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 108 FTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDASP 187
Cdd:cd15223   80 IHFFTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 188 LLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYV--Q 265
Cdd:cd15223  160 LVSLACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLtyR 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 153791876 266 TKVTSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGAL 305
Cdd:cd15223  240 FGKTIPPDVHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

31-301

3.27e-55

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 180.56 E-value: 3.27e-55

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  31 ILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvdGGKNISYADCLSQLFIFTF 110
Cdd:cd15221    5 IPFCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWF--GAGEISFDGCLTQMFFVHF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 111 LGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDASPLLA 190
Cdd:cd15221   83 VFVTESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIAR 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 191 LSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQTKVTS 270
Cdd:cd15221  163 LACADITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLTHRFGR 242

                        250       260       270
                 ....*....|....*....|....*....|...
gi 153791876 271 SI--NFNKVVSVFYSVVTPMLNPLIYSLRNKEV 301
Cdd:cd15221  243 HIprHVHILLANLYVLVPPMLNPIVYGVKTKQI 275

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

31-301

5.30e-54

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 177.48 E-value: 5.30e-54

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  31 ILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvdGGKNISYADCLSQLFIFTF 110
Cdd:cd15917    5 IPFCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWF--NAREISFDACLAQMFFIHS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 111 LGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDASPLLA 190
Cdd:cd15917   83 FTAMESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 191 LSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQTKVTS 270
Cdd:cd15917  163 LACGDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRFGH 242

                        250       260       270
                 ....*....|....*....|....*....|...
gi 153791876 271 SI--NFNKVVSVFYSVVTPMLNPLIYSLRNKEV 301
Cdd:cd15917  243 HVppHVHILLANLYLLLPPMLNPIVYGVRTKQI 275

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

31-301

2.89e-53

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 175.68 E-value: 2.89e-53

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  31 ILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvdGGKNISYADCLSQLFIFTF 110
Cdd:cd15950    5 IPFCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWL--GSAEISFEACFTQMFFVHS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 111 LGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWL--VGFLTPILpiYLLSQLTFYGPNVIDHFSCDASPL 188
Cdd:cd15950   83 FTAVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLraLLFMTPLT--CLVTSLPYCGSRVVPHSYCEHMAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 189 LALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFY-GTLFFMYVQtK 267
Cdd:cd15950  161 VKLACADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYiPGLLSIYTQ-R 239

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 153791876 268 VTSSINFNKVVSV--FYSVVTPMLNPLIYSLRNKEV 301
Cdd:cd15950  240 FGQGVPPHTQVLLadLYLLVPPMLNPIIYGMRTKQI 275

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

31-301

8.95e-50

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 166.67 E-value: 8.95e-50

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  31 ILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvdGGKNISYADCLSQLFIFTF 110
Cdd:cd15953    5 IPFCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWF--NLKEITFSGCLTQMFFIHT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 111 LGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTpILPI-YLLSQLTFYGPNVIDHFSCDASPLL 189
Cdd:cd15953   83 LSIMESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLL-ILPLpLLLSRLPFCANRIIPHTYCEHMAVV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 190 ALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQTKVT 269
Cdd:cd15953  162 KLACGDTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLTHRFG 241

                        250       260       270
                 ....*....|....*....|....*....|....
gi 153791876 270 SSI--NFNKVVSVFYSVVTPMLNPLIYSLRNKEV 301
Cdd:cd15953  242 QGIapHIHIILANLYLLVPPMLNPIIYGVKTKEI 275

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

31-301

1.89e-49

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 165.63 E-value: 1.89e-49

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  31 ILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvdGGKNISYADCLSQLFIFTF 110
Cdd:cd15952    5 FPFCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWF--NLREISFGGCLAQMFFIHT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 111 LGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDASPLLA 190
Cdd:cd15952   83 FTGMESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 191 LSCSDVtwKETVDF-LVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQTKVT 269
Cdd:cd15952  163 LACASI--RINIIYgLFAISVLVLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRFG 240

                        250       260       270
                 ....*....|....*....|....*....|....
gi 153791876 270 SSI--NFNKVVSVFYSVVTPMLNPLIYSLRNKEV 301
Cdd:cd15952  241 HNIprYIHILLANLYVVLPPMLNPVIYGVRTKQI 274

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

12-302

1.24e-47

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 161.48 E-value: 1.24e-47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  12 TEFVMMGFAGIHEAHLLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvd 91
Cdd:cd15949    2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWF-- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  92 GGKNISYADCLSQLFIFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTpILPIYLLSQ-L 170
Cdd:cd15949   80 SSNEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLY-ISPLPLLVRrL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 171 TFYGPNVIDHFSCDASPLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLT 250
Cdd:cd15949  159 PWYRTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVC 238

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 153791876 251 VVSLFygtlffmYVQTKVTSSIN-FNKVVSV--------FYSVVTPMLNPLIYSLRNKEVK 302
Cdd:cd15949  239 AILAF-------YVPIAVSSLIHrFGQNVPPpthillanFYLLIPPMLNPIVYGVRTKQIQ 292

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

29-301

1.50e-46

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 158.43 E-value: 1.50e-46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  29 FFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvdGGKNISYADCLSQLFIF 108
Cdd:cd15222    3 ISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWF--NAREISFDACLAQMFFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 109 TFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDASPL 188
Cdd:cd15222   81 HTFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 189 LALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGT---LFFMYVQ 265
Cdd:cd15222  161 MKLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPmigLSMVHRF 240

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 153791876 266 TKVTSSInFNKVVSVFYSVVTPMLNPLIYSLRNKEV 301
Cdd:cd15222  241 GKHASPL-VHVLMANVYLLVPPVLNPIIYSVKTKQI 275

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

31-301

3.81e-44

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 152.12 E-value: 3.81e-44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  31 ILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvdGGKNISYADCLSQLFIFTF 110
Cdd:cd15951    5 IPFCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWF--NSREIDFSACLTQMFFIHS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 111 LGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDASPLLA 190
Cdd:cd15951   83 FSTMESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 191 LSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQTKVTS 270
Cdd:cd15951  163 LACADTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLTHRFGH 242

                        250       260       270
                 ....*....|....*....|....*....|...
gi 153791876 271 SI--NFNKVVSVFYSVVTPMLNPLIYSLRNKEV 301
Cdd:cd15951  243 NVppHVHILIANVYLLVPPMLNPIIYGVRTKQI 275

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

33-310

7.22e-42

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 146.11 E-value: 7.22e-42

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876   33 FLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvdGGKNISYADCLSQLFIFTFLG 112
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWF--GLREISFEACLTQMFFIHKFS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  113 ATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDASPLLALS 192
Cdd:pfam13853  79 IMESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  193 CSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQTKVTSSI 272
Cdd:pfam13853 159 CADIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNV 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 153791876  273 N--FNKVVSVFYSVVTPMLNPLIYSLRNKEVKGALGRVFS 310
Cdd:pfam13853 239 PplLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRMLL 278

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

26-302

6.09e-40

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 141.20 E-value: 6.09e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  26 HLLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGVDggKNISYADCLSQL 105
Cdd:cd15948    1 HPWISIPFCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNS--REINFNACLVQM 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 106 FIFTFLGATECFLLAAMAYDRYVAICMPLHYGAFV--SWGTCIRLAAACWLVGFLTPiLPiYLLSQLTFYGPNVIDHFSC 183
Cdd:cd15948   79 FFLHSFSIMESAVLLAMAFDRYVAICNPLRYATILtnSVITKIGLAALARAVTLMTP-LP-FLLRRLPYCRSHVIAHCYC 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 184 DASPLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMY 263
Cdd:cd15948  157 EHMAVVKLACGDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSS 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 153791876 264 VQTKVTSSI--NFNKVVSVFYSVVTPMLNPLIYSLRNKEVK 302
Cdd:cd15948  237 TMHRFARHVapHVHILLANFYLLFPPMMNPIVYGVKTKQIR 277

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

31-301

1.42e-39

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 140.00 E-value: 1.42e-39

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  31 ILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvdGGKNISYADCLSQLFIFTF 110
Cdd:cd15956    5 LPFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWF--GATAISSYVCLSQMFLVHA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 111 LGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDASPLLA 190
Cdd:cd15956   83 FSAMESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 191 LSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQTKVTS 270
Cdd:cd15956  163 LACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRFGH 242

                        250       260       270
                 ....*....|....*....|....*....|...
gi 153791876 271 SI--NFNKVVSVFYSVVTPMLNPLIYSLRNKEV 301
Cdd:cd15956  243 SVpsAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

43-294

2.91e-34

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 125.49 E-value: 2.91e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876   43 ENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGVdGGKNISYADCLSQLFIFTFLGATECFLLAAM 122
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNH-GDWPFGSALCKIVGALFVVNGYASILLLTAI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  123 AYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNvidHFSCDASPLLALSCsdvtwKETV 202
Cdd:pfam00001  80 SIDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGN---VTVCFIDFPEDLSK-----PVSY 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  203 DFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERW-------KAFSTCAAHLTVVSLFYGTLFFMYVQTKVTSSINFN 275
Cdd:pfam00001 152 TLLISVLGFLLPLLVILVCYTLIIRTLRKSASKQKSSertqrrrKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELS 231

                         250       260
                  ....*....|....*....|....*
gi 153791876  276 KVVSVFYSV------VTPMLNPLIY 294
Cdd:pfam00001 232 RLLDKALSVtlwlayVNSCLNPIIY 256

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

31-301

2.29e-31

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 118.72 E-value: 2.29e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  31 ILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvdGGKNISYADCLSQLFIFTF 110
Cdd:cd15955    5 IPFCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWF--QLREISFNACLAQMFFIHT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 111 LGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVG-FLTPILPIYLLSQLTFYGPNVIDHFSCDASPLL 189
Cdd:cd15955   83 LQAFESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAvVLIIPCPLLIKLRLHHFRSTVISHSYCEHMAVV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 190 ALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQTKVT 269
Cdd:cd15955  163 KLAADDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHRFG 242

                        250       260       270
                 ....*....|....*....|....*....|....
gi 153791876 270 SSI--NFNKVVSVFYSVVTPMLNPLIYSLRNKEV 301
Cdd:cd15955  243 HHVapYVHILLSNLYLLVPPVLNPIVYGVKTKQI 276

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

31-301

2.55e-31

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 118.39 E-value: 2.55e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  31 ILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvdGGKNISYADCLSQLFIFTF 110
Cdd:cd15954    5 IPFCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWF--NLKEISFNACLVQMFFVHT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 111 LGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSCDASPLLA 190
Cdd:cd15954   83 FTGMESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 191 LSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSLFYGTLFFMYVQTKVTS 270
Cdd:cd15954  163 LACANIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHRFGG 242

                        250       260       270
                 ....*....|....*....|....*....|....
gi 153791876 271 ---SINFNKVVSVFYSVVTPMLNPLIYSLRNKEV 301
Cdd:cd15954  243 hhiTPHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

29-298

8.93e-20

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 86.96 E-value: 8.93e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  29 FFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIgvDGGKNISYADCLSQLFIF 108
Cdd:cd00637    1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLL--LGRWWFGDALCKLLGFLQ 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 109 TFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFscdaspl 188
Cdd:cd00637   79 SVSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLC------- 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 189 lalsCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLH--------------IRSAAERWKAFSTCaahLTVVSL 254
Cdd:cd00637  152 ----WPDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRhrrrirssssnssrRRRRRRERKVTKTL---LIVVVV 224

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 153791876 255 F------YGTLFFMYVQTKVTSSINFN-KVVSVFYSVVTPMLNPLIYSLRN 298
Cdd:cd00637  225 FllcwlpYFILLLLDVFGPDPSPLPRIlYFLALLLAYLNSAINPIIYAFFN 275

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

27-305

3.46e-10

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 59.91 E-value: 3.46e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFltmylFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPkmLAGFIGVDGGKNISYADCLSQLF 106
Cdd:cd14969    6 YLSLIGV-----LGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYP--LSFYSNLSGRWSFGDPGCVIYGF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLhYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQltfYGPNVIDHfscdas 186
Cdd:cd14969   79 AVTFLGLVSISTLAALAFERYLVIVRPL-KAFRLSKRRALILIAFIWLYGLFWALPPLFGWSS---YVPEGGGT------ 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 187 pllalSCSdVTWKET----VDFLVSLAVL--LASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAA------HLTVVSL 254
Cdd:cd14969  149 -----SCS-VDWYSKdpnsLSYIVSLFVFcfFLPLAIIIFCYYKIYRTLRKMSKRAARRKNSAITKRtkkaekKVAKMVL 222

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 153791876 255 FYGTLFFM----YVQTKVTSSINFNKVVSVFYSVVTPML-------NPLIYSLRNKEVKGAL 305
Cdd:cd14969  223 VMIVAFLIawtpYAVVSLYVSFGGESTIPPLLATIPALFaksstiyNPIIYVFMNKQFRRAL 284

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

28-305

8.96e-10

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 58.34 E-value: 8.96e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  28 LFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAgfIGVDGGKNISYADCLSQLFI 107
Cdd:cd14967    1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAV--YTLLGYWPFGPVLCRFWIAL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 108 FTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIyllSQLTFYGPNVIDHFSCDASP 187
Cdd:cd14967   79 DVLCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPL---VGWRDETQPSVVDCECEFTP 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 188 LLALScsdvtwketvdFLVSLAVLLASSMVIAVSYGNIvwtllhIRSAAERWKAFSTCAAhltVVSLFYGT---LFFMYV 264
Cdd:cd14967  156 NKIYV-----------LVSSVISFFIPLLIMIVLYARI------FRVARRELKAAKTLAI---IVGAFLLCwlpFFIIYL 215

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 153791876 265 qtkVTSSINFNKVVSVFYSVVT------PMLNPLIYSLRNKEVKGAL 305
Cdd:cd14967  216 ---VSAFCPPDCVPPILYAVFFwlgylnSALNPIIYALFNRDFRRAF 259

7tmA_Adenosine_R_A2A

cd15068

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...

27-162

1.80e-07

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320196 [Multi-domain] Cd Length: 293 Bit Score: 51.86 E-value: 1.80e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGVdggknisYADCLSQLF 106
Cdd:cd15068    1 SVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGF-------CAACHGCLF 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 153791876 107 IFTF---LGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGF---LTPIL 162
Cdd:cd15068   74 IACFvlvLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFaigLTPML 135

7tmA_EDG-like

cd14972

endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...

31-305

1.87e-07

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 51.52 E-value: 1.87e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  31 ILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLScleiwytsvtVPKMLAGFIGVDGGKNISYADC--------L 102
Cdd:cd14972    3 VVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLA----------AADLLAGIAFVFTFLSVLLVSLtpspatwlL 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 103 SQLFIFTFLGATECFLLAaMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIyllsqltfYGPNVIDhfs 182
Cdd:cd14972   73 RKGSLVLSLLASAYSLLA-IAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALLPV--------LGWNCVL--- 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 183 CDASpllalSCSDVTWKETVDFLVSLAVLLASSMV-IAVSYGNIVWTLlhiRSAAERWKAFSTCA--------------- 246
Cdd:cd14972  141 CDQE-----SCSPLGPGLPKSYLVLILVFFFIALViIVFLYVRIFWCL---WRHANAIAARQEAAvpaqpstsrklaktv 212

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 153791876 247 AHLTVVSLFYGTLFFMY----VQTKVTSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGAL 305
Cdd:cd14972  213 VIVLGVFLVCWLPLLILlvldVLCPSVCDIQAVFYYFLVLALLNSAINPIIYAFRLKEMRRAV 275

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

44-163

2.14e-06

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 48.41 E-value: 2.14e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  44 NLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPkmLAgfIGVDGGKNISYADCLSQLFIFTFLGATECFLLAAMA 123
Cdd:cd14968   18 NVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIP--LA--ILISLGLPTNFHGCLFMACLVLVLTQSSIFSLLAIA 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 153791876 124 YDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILP 163
Cdd:cd14968   94 IDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTP 133

7tmA_Adenosine_R_A2B

cd15069

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...

28-162

2.64e-06

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320197 [Multi-domain] Cd Length: 294 Bit Score: 48.01 E-value: 2.64e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  28 LFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMlagfIGVDGGKNISYADCLSQLFI 107
Cdd:cd15069    2 TYVALELIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFA----ITISLGFCTDFHSCLFLACF 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 153791876 108 FTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGF---LTPIL 162
Cdd:cd15069   78 VLVLTQSSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFgigLTPFL 135

7tmA_S1PR

cd15102

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...

31-305

9.36e-06

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).

Pssm-ID: 320230 [Multi-domain] Cd Length: 270 Bit Score: 46.31 E-value: 9.36e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  31 ILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLagfigVDGGKNISYADclSQLFI--- 107
Cdd:cd15102    5 VVFVAICCFIVLENLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGAAYLANIL-----LSGARTLRLSP--AQWFLreg 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 108 --FTFLGATeCFLLAAMAYDRYVAICMPLHYGAfVSWGTCIRLAAACWLVGFLTPILPIyllsqltfYGPNVIDHFScDA 185
Cdd:cd15102   78 smFVALSAS-VFSLLAIAIERHLTMAKMKPYGA-SKTSRVLLLIGACWLISLLLGGLPI--------LGWNCLGALD-AC 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 186 SPLLALSCsdvtwKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRS--AAERWKAFSTCAAHLTVVSLF---YGTLF 260
Cdd:cd15102  147 STVLPLYS-----KHYVLFCVTIFAGILAAIVALYARIYCLVRASGRKAtrASASPRSLALLKTVLIVLLVFiacWGPLF 221

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 153791876 261 FMY---VQTKV-TSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGAL 305
Cdd:cd15102  222 ILLlldVACPVkTCPILYKADWFLALAVLNSALNPIIYTLRSRELRRAV 270

7tmA_CCKR-like

cd14993

cholecystokinin receptors and related proteins, member of the class A family of ...

28-231

4.84e-05

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.

Pssm-ID: 320124 [Multi-domain] Cd Length: 296 Bit Score: 44.13 E-value: 4.84e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  28 LFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFI------GVDGGKNISYADC 101
Cdd:cd14993    2 VLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVyrpwvfGEVLCKAVPYLQG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 102 LSQlfiftflgATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTpILPIYLLSQLTFYGPNVIDhf 181
Cdd:cd14993   82 VSV--------SASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIII-MLPLLVVYELEEIISSEPG-- 150

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 153791876 182 scdasPLLALSCSDV----TWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLH 231
Cdd:cd14993  151 -----TITIYICTEDwpspELRKAYNVALFVVLYVLPLLIISVAYSLIGRRLWR 199

7tmA_MC2R_ACTH_R

cd15350

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...

32-136

2.07e-04

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320472 [Multi-domain] Cd Length: 270 Bit Score: 42.08 E-value: 2.07e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  32 LFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLScleIWYTSVTVPKML---------AGFIGVDGGKNISYADCL 102
Cdd:cd15350    6 VFFTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLA---VSDMLGSLYKTLeniliiladMGYLNRRGPFETKLDDIM 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 153791876 103 SQLFIFTFLGATecFLLAAMAYDRYVAICMPLHY 136
Cdd:cd15350   83 DSLFCLSLLGSI--FSILAIAADRYITIFHALRY 114

7tmA_Cannabinoid_R

cd15099

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...

31-305

2.25e-04

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 320227 [Multi-domain] Cd Length: 281 Bit Score: 42.13 E-value: 2.25e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  31 ILFLTMYLFTLVENLAIILVVGLDHRLR-RPMYFFLTHLSCLEIWYTSVTVPKMLAG--FIGVDGgknisyadclSQLFI 107
Cdd:cd15099    5 VLCFLAGPVTFLENILVLLTILSSTALRrRPSYLFIGSLALADMLASVIFTISFLDFhvFHQRDS----------RNLFL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 108 FTFLGATECFL-----LAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPnvidhfs 182
Cdd:cd15099   75 FKLGGVTMAFTasvgsLLLTALDRYLCIYQPSNYKLLVTRTRAKVAILLMWCVTIIISFLPLMGWRCKTWDSP------- 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 183 cdaspllalsCSDVTWKETVDFLVS-LAVLLASSMVIAVSYGNIVWTL-LHIRSAAERW----------------KAFST 244
Cdd:cd15099  148 ----------CSRLFPYIDRHYLASwTGLQLVLLFLIIYAYPYILWKAhRHEANMGGPKlgrqqvkgqarmrmdiRLAKT 217

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 153791876 245 CAAHLTVVSLFYGTLFFMYVQTKVTSSINFNKVVSVFYS---VVTPMLNPLIYSLRNKEVKGAL 305
Cdd:cd15099  218 LSLILLVLAICWLPVLAFMLVDVRVTLTNKQKRMFAFCSmlcLVNSCVNPIIYALRSRELRGAM 281

7tmA_GPRnna14-like

cd15001

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...

29-183

2.93e-04

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320132 [Multi-domain] Cd Length: 266 Bit Score: 41.88 E-value: 2.93e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  29 FFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLA--GFIGVDGGKNISYADCLSQLF 106
Cdd:cd15001    2 VIIVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAeyFSPTWSLGAFLCKAVAYLQLL 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 153791876 107 IFTflgaTECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDHFSC 183
Cdd:cd15001   82 SFI----CSVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFGQGLVRYESENGVTVYHC 154

7tmA_MC1R

cd15351

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...

32-164

3.74e-04

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320473 [Multi-domain] Cd Length: 271 Bit Score: 41.32 E-value: 3.74e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  32 LFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKML------AGFIGVDgGKNISYADCLSQL 105
Cdd:cd15351    6 LFLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLfmllleHGVLVCR-APMLQHMDNVIDT 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 153791876 106 FIFTFLGATECFlLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPI 164
Cdd:cd15351   85 MICSSVVSSLSF-LGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVSSTLFI 142

7tmA_purinoceptor-like

cd14982

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...

28-300

4.89e-04

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341318 [Multi-domain] Cd Length: 283 Bit Score: 41.10 E-value: 4.89e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  28 LFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTsVTVPKMLAGFIGvdgGKNISYADCLSQLFI 107
Cdd:cd14982    2 LFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFV-LTLPFRIYYYLN---GGWWPFGDFLCRLTG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 108 FTFLGATEC--FLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTpILPIYLLSQLTFYGPNVIDHFScDA 185
Cdd:cd14982   78 LLFYINMYGsiLFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVA-SVPLLLLRSTIAKENNSTTCFE-FL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 186 SPLLALSCSDVTWKETVDFLVSLAvllassmVIAVSYGNIVWTLLHIRSAAERW----KAFSTCAAHLTVVSLFYGT--- 258
Cdd:cd14982  156 SEWLASAAPIVLIALVVGFLIPLL-------IILVCYSLIIRALRRRSKQSQKSvrkrKALRMILIVLAVFLVCFLPyhv 228

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 153791876 259 --LFFMYVQTKVTSSINFNKVVSVFY------SVVTPMLNPLIYSLRNKE 300
Cdd:cd14982  229 trILYLLVRLSFIADCSARNSLYKAYritlclASLNSCLDPLIYYFLSKT 278

7tmA_MCR

cd15103

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

32-164

5.38e-04

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320231 [Multi-domain] Cd Length: 270 Bit Score: 40.94 E-value: 5.38e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  32 LFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHL-------SCLEIWYTSVTVpkMLAGFIGVDGGKNISYADCLSQ 104
Cdd:cd15103    6 VFLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLavadmlvSVSNALETIVII--LLNNGYLVPRDSFEQHIDNVID 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 105 LFIFTFLGATECFLLaAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPI 164
Cdd:cd15103   84 SMICSSLLASICSLL-AIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGILFI 142

7tmA_SREB-like

cd15005

super conserved receptor expressed in brain and related proteins, member of the class A family ...

38-172

6.27e-04

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320134 [Multi-domain] Cd Length: 329 Bit Score: 40.90 E-value: 6.27e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  38 LFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGfIGVDGGKNISYADCLSQLFIFTFLGATECF 117
Cdd:cd15005   12 CVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMAS-VRHGSGWIYGALSCKVIAFLAVLFCFHSAF 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 153791876 118 LLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTF 172
Cdd:cd15005   91 TLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFPPVFDVGTYTF 145

7tmA_PR4-like

cd15392

neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...

28-227

7.33e-04

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.

Pssm-ID: 320514 [Multi-domain] Cd Length: 287 Bit Score: 40.42 E-value: 7.33e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  28 LFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVP-KMLAGFI------GVDGGKNISYAD 100
Cdd:cd15392    2 IIILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPfSFIALLIlqywpfGEFMCPVVNYLQ 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 101 CLSqlfifTFLGAtecFLLAAMAYDRYVAICMPLHygAFVSWGTCIRLAAACWLVGFLTPiLPIYLLSQLTFYGPNvidh 180
Cdd:cd15392   82 AVS-----VFVSA---FTLVAISIDRYVAIMWPLR--PRMTKRQALLLIAVIWIFALATA-LPIAITSRLFEDSNA---- 146

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 153791876 181 fSCDASpllalSCSDVTWKETVDFLVSLAVLLAS----SMVIAVSYGNIVW 227
Cdd:cd15392  147 -SCGQY-----ICTESWPSDTNRYIYSLVLMILQyfvpLAVLVFTYTRIGI 191

7tmA_MC3R

cd15352

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...

32-155

1.30e-03

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320474 [Multi-domain] Cd Length: 272 Bit Score: 39.87 E-value: 1.30e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  32 LFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYT------SVTVPKMLAGFIGVDgGKNISYADCLSQL 105
Cdd:cd15352    6 VFLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSvsnsleTIMIAVLNSGYLVIS-DQFIQHMDNVFDS 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 153791876 106 FIFTFLGATECFLLaAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLV 155
Cdd:cd15352   85 MICISLVASICNLL-AIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWVV 133

7tmA_Parietopsin

cd15085

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...

27-302

1.41e-03

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.

Pssm-ID: 320213 [Multi-domain] Cd Length: 280 Bit Score: 39.84 E-value: 1.41e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMyLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAgfIGVDGGKNISYADCLSQLF 106
Cdd:cd15085    2 ILSFLMFLNA-TFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTV--TNYEGYFYLGDAFCIFQGF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 107 IFTFLGATECFLLAAMAYDRYVAICMPLhyGAF-VSWGTCIRLAAACWLVGFLTPILPIYLLSQltfYGPNVIDhfscda 185
Cdd:cd15085   79 AVNYFGIVSLWSLTLLAYERYNVVCKPM--GGLkLSTKRGYQGLLFIWLFCLFWAVAPLFGWSS---YGPEGVQ------ 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 186 spllaLSCSdVTWKE----TVDFLVS--LAVLLASSMVIAVSYGNIVWTLLHIRSAAERwKAFSTCAA---HLTVVSLFY 256
Cdd:cd15085  148 -----TSCS-IGWEErswsNYSYLILyfLMCFVIPVAIIGFSYGNVLRSLHKLNKKIEQ-QGGKNCPEeeeRAVIMVLAM 220

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 153791876 257 GTLFFM----YVQTKVTSSIN-------FNKVVSVFYSVVTPMLNPLIYSLRNKEVK 302
Cdd:cd15085  221 VIAFLIcwlpYTVFALIVVVNpelsispLAATMPTYFAKTSPVYNPIIYIFLNKQFR 277

7tmA_CB2

cd15341

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...

31-305

1.42e-03

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 320463 [Multi-domain] Cd Length: 279 Bit Score: 39.82 E-value: 1.42e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  31 ILFLTMYLFTLVENLAIILVVGLDHRLRR-PMYFFLTHLSCLEIWYTSVTVPKMLAG--FIGVDGgknisyadclSQLFI 107
Cdd:cd15341    5 VLCTLCGLLCILENVAVLYLILSSPKLRRkPSYLFIGSLALADFLASVVFACSFVDFhvFHGVDS----------SAIFL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 108 FTFLGATECFL-----LAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYllsqltfygpnvidHFS 182
Cdd:cd15341   75 LKLGGVTMSFTaslgsLLLMAFDRYVCIYYPSEYKALVTRKRALVALAVMWVLTALIAYLPLM--------------GWN 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 183 CDAsplLALSCSDVTWKETVDFLVSLAVLLASSMV-IAVSYGNIVWTL-LHIRSAAERW--------------KAFSTCA 246
Cdd:cd15341  141 CCP---LNSPCSELFPLIPNDYLLSWLLLVAILLSgIIYTYGHVLWKAhKHVVYMEKHQdqqgpgnarmrldvRLAKTLG 217

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 153791876 247 AHLTVVSLFYGTLFFMYVQTKVTSSINFNKVVSVFYS---VVTPMLNPLIYSLRNKEVKGAL 305
Cdd:cd15341  218 LVLAVLLICWSPVLALMMHSLFTSLSDHIKKAFAFCStlcLVNSMVNPIIYALRSRELRSSL 279

7tmA_S1PR1_Edg1

cd15346

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...

31-305

1.45e-03

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).

Pssm-ID: 320468 [Multi-domain] Cd Length: 277 Bit Score: 39.47 E-value: 1.45e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  31 ILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWY-TSVTVPKMLAGfigvdggkNISYADCLSQLFI-- 107
Cdd:cd15346    5 VVFIIICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAgVAYTANLLLSG--------ATTYKLTPTQWFLre 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 108 ---FTFLGATeCFLLAAMAYDRYVAIC-MPLHYGAFVSwgTCIRLAAACWLVGFLTPILPIyllsqltfYGPNVIDHFSc 183
Cdd:cd15346   77 gsmFVALSAS-VFSLLAIAIERYITMLkMKLHNGSNSF--RSFLLISACWVISLILGGLPI--------MGWNCISALS- 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 184 daspllalSCSDVT---WKETVDFLVSLAVLLASSMVIAVSYgniVWTLLHIRSAAERWKAFSTCAAH------------ 248
Cdd:cd15346  145 --------SCSTVLplyHKHYILFCTTVFTLLLLSIVILYCR---IYSLVRTRSRRLTFRKNIRKASRsseksmallktv 213

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 153791876 249 LTVVSLFYG------TLFFMYVQTKV-TSSINFNKVVSVFYSVVTPMLNPLIYSLRNKEVKGAL 305
Cdd:cd15346  214 IIVLSVFIAcwaplfILLLLDVGCKVkTCSILFKAEYFLVLAVLNSATNPIIYTLTNKEMRRAF 277

7tmA_GHSR-like

cd15928

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...

31-211

1.47e-03

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.

Pssm-ID: 320594 [Multi-domain] Cd Length: 288 Bit Score: 39.78 E-value: 1.47e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  31 ILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIwytsVTVPKMLAGFIGVDGGKNISYADCLSQLFIFTF 110
Cdd:cd15928    5 AVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDL----LIFLVLPLDLYRLWRYRPWRFGDLLCRLMYFFS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 111 LGATECFLL--AAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLtPILPIYLLSQLT-FYGPNVIDHFSCDASP 187
Cdd:cd15928   81 ETCTYASILhiTALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIV-SAGPALVLVGVEhIQGQQTPRGFECTVVN 159

                        170       180
                 ....*....|....*....|....
gi 153791876 188 LLALSCSDVTWKETVDFLVSLAVL 211
Cdd:cd15928  160 VSSGLLSVMLWVSTSFFFVPMVCL 183

7tmA_SREB2_GPR85

cd15218

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...

40-172

1.67e-03

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320346 [Multi-domain] Cd Length: 330 Bit Score: 39.63 E-value: 1.67e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  40 TLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMlagFIGVDGGKNISYADCLSQlfIFTFLGATECFLL 119
Cdd:cd15218   14 SVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFPFV---FTSVKNGSTWTYGTLTCK--VIAFLGVLSCFHT 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 153791876 120 AAMAY----DRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTF 172
Cdd:cd15218   89 AFMLFcisvTRYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSF 145

7tmA_MC4R

cd15353

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...

32-136

1.76e-03

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320475 [Multi-domain] Cd Length: 269 Bit Score: 39.51 E-value: 1.76e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  32 LFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYT----SVTVPKMLAGFIGVDGGKNISYADCLSQLFI 107
Cdd:cd15353    6 VFVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSvsngSETVVITLLNGNDTDAQSFTVNIDNVIDSVI 85

                         90       100
                 ....*....|....*....|....*....
gi 153791876 108 FTFLGATECFLLaAMAYDRYVAICMPLHY 136
Cdd:cd15353   86 CSSLLASICSLL-SIAVDRYFTIFYALQY 113

7tmA_ETH-R

cd14997

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...

37-211

2.09e-03

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320128 [Multi-domain] Cd Length: 294 Bit Score: 39.20 E-value: 2.09e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  37 YLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGVDG---GKNIsyadCLSQLFIFTFLGA 113
Cdd:cd14997   11 FVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWAREPwllGEFM----CKLVPFVELTVAH 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 114 TECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLT--PILPIYLLSQLTFYGPNVIDhfSCDASPLLAL 191
Cdd:cd14997   87 ASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTssPVLFITEFKEEDFNDGTPVA--VCRTPADTFW 164

                        170       180
                 ....*....|....*....|
gi 153791876 192 SCSDVTWKETVDFLVSLAVL 211
Cdd:cd14997  165 KVAYILSTIVVFFVVPLAIL 184

7tmA_GPR119_R_insulinotropic_receptor

cd15104

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...

39-305

2.25e-03

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320232 [Multi-domain] Cd Length: 283 Bit Score: 38.89 E-value: 2.25e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  39 FTLVENLAIILVVGLDHRLRR-PMYFFLThlsCLEIWYTSVTVpkMLAGFIGVD---GGKNISYADCLSQLFIFTFLGAT 114
Cdd:cd15104   12 LIITGNLLVIVALLKLIRKKDtKSNCFLL---NLAIADFLVGL--AIPGLATDEllsDGENTQKVLCLLRMCFVITSCAA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 115 ECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILP-IYLLSQLTFYGPNVIDHFSCDASPLLALSC 193
Cdd:cd15104   87 SVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGFLPlISPQFQQTSYKGKCSFFAAFHPRVLLVLSC 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 194 SDVTWKETVDFLVSLAVLLASSM------VIAVSYGNIVwtllHIRSAAERWKAFSTCAAHLTVVSLFYGTLFF-MYVQT 266
Cdd:cd15104  167 MVFFPALLLFVFCYCDILKIARVhsraiyKVEHALARQI----HPRRTLSDFKAARTVAVLIGCFLLSWLPFQItGLVQA 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 153791876 267 KVTSSINFNKVVSV--FYSVVTPMLNPLIYSLRNKEVKGAL 305
Cdd:cd15104  243 LCDECKLYDVLEDYlwLLGLCNSLLNPWIYAFWQKEVRRAL 283

7tmA_Adenosine_R_A1

cd15071

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...

38-165

2.28e-03

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.

Pssm-ID: 341323 [Multi-domain] Cd Length: 290 Bit Score: 39.06 E-value: 2.28e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  38 LFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPkmLAGFIGVdgGKNISYADCLSQLFIFTFLGATECF 117
Cdd:cd15071   12 LVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAIIINI--GPQTEFYSCLMVACPVLILTQSSIL 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 153791876 118 LLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIY 165
Cdd:cd15071   88 ALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFLVGLTPMF 135

7tmA_Beta3_AR

cd15959

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...

36-164

3.14e-03

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.

Pssm-ID: 320625 [Multi-domain] Cd Length: 302 Bit Score: 38.73 E-value: 3.14e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  36 MYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKmlAGFIGVDGGKNISYADC--LSQLFIFTFLGA 113
Cdd:cd15959   10 AILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPP--GATILLTGHWPLGTTVCelWTSVDVLCVTAS 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 153791876 114 TECflLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPI 164
Cdd:cd15959   88 IET--LCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFLPI 136

7tmA_Prostanoid_R

cd14981

G protein-coupled receptors for prostanoids, member of the class A family of ...

106-165

3.63e-03

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.

Pssm-ID: 320112 [Multi-domain] Cd Length: 288 Bit Score: 38.38 E-value: 3.63e-03

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 106 FIFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIY 165
Cdd:cd14981   81 FMMSFFGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIASLPLL 140

7tmA_Trissin_R

cd15012

trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...

28-305

4.90e-03

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320140 [Multi-domain] Cd Length: 277 Bit Score: 38.19 E-value: 4.90e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  28 LFFILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGVDG--GKNIsyadCLSQL 105
Cdd:cd15012    1 IFIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWpfGEVL----CRMYQ 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 106 FIFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPIlPIYLLSQltFYGPNVIDHFSCDA 185
Cdd:cd15012   77 FVHSLSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNT-PYFVFSQ--TVEILVTQDGQEEE 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 186 SPLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWKAFSTCAAHLTVVSL-FYGTLFFMYV 264
Cdd:cd15012  154 ICVLDREMFNSKLYDTINFIVWYLIPLLIMTVLYSKISIVLWKSSSIEARRKVVRLLVAVVVSFALCNLpYHARKMWQYW 233

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 153791876 265 QTKVTSSINFNKVVSVFYSVVTPM---LNPLIYSLRNKEVKGAL 305
Cdd:cd15012  234 SEPYRCDSNWNALLTPLTFLVLYFnsaVNPLLYAFLSKRFRQSM 277

7tmA_FMRFamide_R-like

cd14978

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...

31-158

5.74e-03

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.

Pssm-ID: 410630 [Multi-domain] Cd Length: 299 Bit Score: 38.00 E-value: 5.74e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  31 ILFLTMYLFTLVENlAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGVDGGKNISYADCLSQLFIFTF 110
Cdd:cd14978    5 YVLPVICIFGIIGN-ILNLVVLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYFLPYIYPL 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 153791876 111 LGATEC---FLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFL 158
Cdd:cd14978   84 ANTFQTasvWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLL 134

7tmA_5-HT2B

cd15306

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...

31-155

5.74e-03

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341347 [Multi-domain] Cd Length: 277 Bit Score: 37.89 E-value: 5.74e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  31 ILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGfIGVDGGKNISYADCLSQLFIFTF 110
Cdd:cd15306    5 LLILMVIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLT-ILFEAMWPLPLVLCPIWLFLDVL 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 153791876 111 LGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLV 155
Cdd:cd15306   84 FSTASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWLI 128

7tmA_NTSR-like

cd14979

neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...

31-220

6.39e-03

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320110 [Multi-domain] Cd Length: 300 Bit Score: 37.72 E-value: 6.39e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  31 ILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGVDGgKNISYADCLSQLFIFTF 110
Cdd:cd14979    5 AIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQYP-WAFGDGGCKLYYFLFEA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 111 LGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLtPILPIYLLSQL-TFYGPNVIDHFS---CDAS 186
Cdd:cd14979   84 CTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSIL-CAIPILFLMGIqYLNGPLPGPVPDsavCTLV 162

                        170       180       190
                 ....*....|....*....|....*....|....
gi 153791876 187 PLLALSCSDVTWKETVDFLVSLAVLLASSMVIAV 220
Cdd:cd14979  163 VDRSTFKYVFQVSTFIFFVLPMFVISILYFRIGV 196

7tmA_Ap5-HTB1-like

cd15065

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...

27-166

6.46e-03

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.

Pssm-ID: 320193 [Multi-domain] Cd Length: 300 Bit Score: 37.72 E-value: 6.46e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  27 LLFFILFLTMylfTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPkmlagFIGVDggkNISYADCLSQLF 106
Cdd:cd15065    3 GIFLSLIIVL---AIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMT-----FAVVN---DLLGYWLFGETF 71

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 153791876 107 IFTFLGA-----TECFL-LAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYL 166
Cdd:cd15065   72 CNIWISFdvmcsTASILnLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFLPIHL 137

7tmA_CCK-BR

cd15979

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...

31-170

6.86e-03

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320645 [Multi-domain] Cd Length: 275 Bit Score: 37.49 E-value: 6.86e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  31 ILFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSC----LEIWYTSVT-VPKMLAGFIgvdggknISYADCLSQL 105
Cdd:cd15979    5 LLYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALsdlmLAVFCMPFTlIPNLMGTFI-------FGEVICKAVA 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 153791876 106 FIFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPI-LPIYLLSQL 170
Cdd:cd15979   78 YLMGVSVSVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIpYPVYSVTVP 143

7tmA_Adenosine_R_A3

cd15070

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...

38-165

7.53e-03

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.

Pssm-ID: 320198 [Multi-domain] Cd Length: 280 Bit Score: 37.45 E-value: 7.53e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  38 LFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGVdggkNISYADCLSQLFIFTFLGATECF 117
Cdd:cd15070   12 LCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIVVSLGV----TIHFYSCLFMSCLLVVFTHASIM 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 153791876 118 LLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIY 165
Cdd:cd15070   88 SLLAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGLTPMF 135

7tmA_V1bR

cd15386

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...

35-168

7.57e-03

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320508 [Multi-domain] Cd Length: 302 Bit Score: 37.47 E-value: 7.57e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  35 TMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTV-PKML----AGFIGVDG-GKNISYADCLSqLFIF 108
Cdd:cd15386    9 AILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALFQVlPQLIweitYRFQGPDLlCRAVKYLQVLS-MFAS 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 109 TFLgatecflLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAAcWLVGFLTPILPIYLLS 168
Cdd:cd15386   88 TYM-------LIMMTVDRYIAVCHPLRTLQQPSRQAYLMIGAT-WLLSCILSLPQVFIFS 139

7tmA_TAAR2_3_4

cd15312

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...

111-158

8.36e-03

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320437 [Multi-domain] Cd Length: 289 Bit Score: 37.33 E-value: 8.36e-03

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 153791876 111 LGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFL 158
Cdd:cd15312   83 LSTTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCL 130

7tmA_capaR

cd15134

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...

121-173

9.16e-03

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.

Pssm-ID: 320262 [Multi-domain] Cd Length: 298 Bit Score: 37.31 E-value: 9.16e-03

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 153791876 121 AMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPIlPIYLLSQLTFY 173
Cdd:cd15134   94 AFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCAL-PFAIQTRIVYL 145

7tmA_Parapinopsin

cd15075

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...

31-302

9.74e-03

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.

Pssm-ID: 320203 [Multi-domain] Cd Length: 279 Bit Score: 37.06 E-value: 9.74e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  31 ILFLTMYLFT---LVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTsvtvpkMLAGFIGVD----GGKNISYADCLS 103
Cdd:cd15075    2 ILSIIMAVFSiasVVLNATVIIVTLRHKQLRQPLNYALVNLAVADLGTT------VFGGLLSVVtnavGYFNLGRVGCVL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 104 QLFIFTFLGATECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAaCWLVGFLTPILPIY------LLSQLTFYGPNV 177
Cdd:cd15075   76 EGFAVAFFGIAALCTVAVIAVDRLFVVCKPLGTLTFQTRHALAGIAS-SWLWSLIWNTPPLFgwgsyqLEGVMTSCAPDW 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 178 IDHFSCDASPLLALscsdvtwketvdFLVSLAVLLAssmVIAVSYGNIVWTLLHIR--SAAER--WKAFSTCAAHLTVVS 253
Cdd:cd15075  155 YSRDPVNVSYILCY------------FSFCFAIPFA---IILVSYGYLLWTLRQVAklGVAEGgsTAKAEVQVARMVVVM 219

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 153791876 254 LF--------YGTlFFMYVQTKVTSSIN-FNKVVSVFYSVVTPMLNPLIYSLRNKEVK 302
Cdd:cd15075  220 VMafllcwlpYAA-FALTVVSKPDVYINpLIATVPMYLAKSSTVYNPIIYIFMNKQFR 276

7tmA_CCK_R

cd15206

cholecystokinin receptors, member of the class A family of seven-transmembrane G ...

32-299

1.00e-02

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320334 [Multi-domain] Cd Length: 269 Bit Score: 36.98 E-value: 1.00e-02

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876  32 LFLTMYLFTLVENLAIILVVGLDHRLRRPMYFFLTHLSCLEIWYTSVTVPKMLAGFIGvdggKNISYADCLSQLFIFtFL 111
Cdd:cd15206    6 LYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLL----RNFIFGEVMCKLIPY-FQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 112 GAT---ECFLLAAMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPIlPIYLLSQLTfygpNVIDHFSCDASPL 188
Cdd:cd15206   81 AVSvsvSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMS-PILVFSNLI----PMSRPGGHKCREV 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791876 189 LALSCSDVTWKETVDFLvslaVLLASSMVIAVSYGNIVWTLLHIRSAAERW-----KAFSTCAAHLTVV---SLFYGTLF 260
Cdd:cd15206  156 WPNEIAEQAWYVFLDLM----LLVIPGLVMSVAYGLISWTLLEAKKRVIRMlfvivVEFFICWTPLYVIntwKAFDPPSA 231

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 153791876 261 FMYVQtkvTSSINFNKVVSVFYSVVtpmlNPLIYSLRNK 299
Cdd:cd15206  232 ARYVS---STTISLIQLLAYISSCV----NPITYCFMNK 263

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01