NCBI Conserved Domain Search

Conserved domains on [gi|52317265|ref|NP_001004754|]

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olfactory receptor 51I2 [Homo sapiens]

Protein Classification

olfactory receptor family 51 protein( domain architecture ID 11607012)

olfactory receptor family 51 protein is an odorant receptor belonging to the G-protein coupled receptor 1 family

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

25-299

5.31e-169

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 469.67 E-value: 5.31e-169

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  25 SWLSGPLCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLI 104
Cdd:cd15222   1 HWISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 105 HFFSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDM 184
Cdd:cd15222  81 HTFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 185 MRLACADISINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTVHRF 264
Cdd:cd15222 161 MKLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVHRF 240

                       250       260       270
                ....*....|....*....|....*....|....*
gi 52317265 265 GKHVPCYIHVLMSNVYLFVPPVLNPLIYSAKTKEI 299
Cdd:cd15222 241 GKHASPLVHVLMANVYLLVPPVLNPIIYSVKTKQI 275

Name

Accession

Description

Interval

E-value

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

25-299

5.31e-169

Pssm-ID: 320350 Cd Length: 275 Bit Score: 469.67 E-value: 5.31e-169

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  25 SWLSGPLCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLI 104
Cdd:cd15222   1 HWISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 105 HFFSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDM 184
Cdd:cd15222  81 HTFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 185 MRLACADISINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTVHRF 264
Cdd:cd15222 161 MKLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVHRF 240

                       250       260       270
                ....*....|....*....|....*....|....*
gi 52317265 265 GKHVPCYIHVLMSNVYLFVPPVLNPLIYSAKTKEI 299
Cdd:cd15222 241 GKHASPLVHVLMANVYLLVPPVLNPIIYSVKTKQI 275

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

31-307

1.68e-112

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 326.77 E-value: 1.68e-112

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265    31 LCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMM 110
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265   111 ESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACA 190
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265   191 DISINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTVHRFGKHVPC 270
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPP 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 52317265   271 YIHVLMSNVYLFVPPVLNPLIYSAKTKEIRRAIFRMF 307
Cdd:pfam13853 241 LLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277

Name

Accession

Description

Interval

E-value

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

25-299

5.31e-169

Pssm-ID: 320350 Cd Length: 275 Bit Score: 469.67 E-value: 5.31e-169

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  25 SWLSGPLCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLI 104
Cdd:cd15222   1 HWISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 105 HFFSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDM 184
Cdd:cd15222  81 HTFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 185 MRLACADISINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTVHRF 264
Cdd:cd15222 161 MKLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVHRF 240

                       250       260       270
                ....*....|....*....|....*....|....*
gi 52317265 265 GKHVPCYIHVLMSNVYLFVPPVLNPLIYSAKTKEI 299
Cdd:cd15222 241 GKHASPLVHVLMANVYLLVPPVLNPIIYSVKTKQI 275

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

26-299

1.96e-126

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 361.99 E-value: 1.96e-126

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  26 WLSGPLCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIH 105
Cdd:cd15917   2 WLSIPFCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 106 FFSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMM 185
Cdd:cd15917  82 SFTAMESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 186 RLACADISINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTVHRFG 265
Cdd:cd15917 162 KLACGDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRFG 241

                       250       260       270
                ....*....|....*....|....*....|....
gi 52317265 266 KHVPCYIHVLMSNVYLFVPPVLNPLIYSAKTKEI 299
Cdd:cd15917 242 HHVPPHVHILLANLYLLLPPMLNPIVYGVRTKQI 275

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

26-299

3.14e-117

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 338.88 E-value: 3.14e-117

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  26 WLSGPLCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIH 105
Cdd:cd15221   2 WISIPFCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 106 FFSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMM 185
Cdd:cd15221  82 FVFVTESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIA 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 186 RLACADISINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTVHRFG 265
Cdd:cd15221 162 RLACADITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLTHRFG 241

                       250       260       270
                ....*....|....*....|....*....|....
gi 52317265 266 KHVPCYIHVLMSNVYLFVPPVLNPLIYSAKTKEI 299
Cdd:cd15221 242 RHIPRHVHILLANLYVLVPPMLNPIVYGVKTKQI 275

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

26-299

6.04e-115

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 332.77 E-value: 6.04e-115

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  26 WLSGPLCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIH 105
Cdd:cd15951   2 WISIPFCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 106 FFSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMM 185
Cdd:cd15951  82 SFSTMESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 186 RLACADISINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTVHRFG 265
Cdd:cd15951 162 KLACADTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLTHRFG 241

                       250       260       270
                ....*....|....*....|....*....|....
gi 52317265 266 KHVPCYIHVLMSNVYLFVPPVLNPLIYSAKTKEI 299
Cdd:cd15951 242 HNVPPHVHILIANVYLLVPPMLNPIIYGVRTKQI 275

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

31-307

1.68e-112

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 326.77 E-value: 1.68e-112

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265    31 LCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMM 110
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265   111 ESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACA 190
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265   191 DISINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTVHRFGKHVPC 270
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPP 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 52317265   271 YIHVLMSNVYLFVPPVLNPLIYSAKTKEIRRAIFRMF 307
Cdd:pfam13853 241 LLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

26-299

8.28e-111

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 322.29 E-value: 8.28e-111

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  26 WLSGPLCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIH 105
Cdd:cd15953   2 WISIPFCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 106 FFSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMM 185
Cdd:cd15953  82 TLSIMESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 186 RLACADISINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTVHRFG 265
Cdd:cd15953 162 KLACGDTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLTHRFG 241

                       250       260       270
                ....*....|....*....|....*....|....
gi 52317265 266 KHVPCYIHVLMSNVYLFVPPVLNPLIYSAKTKEI 299
Cdd:cd15953 242 QGIAPHIHIILANLYLLVPPMLNPIIYGVKTKEI 275

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

26-299

3.37e-109

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 318.17 E-value: 3.37e-109

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  26 WLSGPLCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIH 105
Cdd:cd15952   2 WIGFPFCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 106 FFSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMM 185
Cdd:cd15952  82 TFTGMESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIA 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 186 RLACADISINSIYGLFVlVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTVHRFG 265
Cdd:cd15952 162 KLACASIRINIIYGLFA-ISVLVLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRFG 240

                       250       260       270
                ....*....|....*....|....*....|....
gi 52317265 266 KHVPCYIHVLMSNVYLFVPPVLNPLIYSAKTKEI 299
Cdd:cd15952 241 HNIPRYIHILLANLYVVLPPMLNPVIYGVRTKQI 274

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

9-300

8.54e-107

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 312.87 E-value: 8.54e-107

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265   9 PAFFLLTGIPGLESSHSWLSGPLCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLN 88
Cdd:cd15949   1 PSTFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  89 ARNITFDACLIQMFLIHFFSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPI 168
Cdd:cd15949  81 SNEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPW 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 169 CRSNVLSHSYCLHPDMMRLACADISINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAV 248
Cdd:cd15949 161 YRTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAI 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 52317265 249 LAFYVPMIGVSTVHRFGKHVPCYIHVLMSNVYLFVPPVLNPLIYSAKTKEIR 300
Cdd:cd15949 241 LAFYVPIAVSSLIHRFGQNVPPPTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

24-300

2.76e-105

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 308.37 E-value: 2.76e-105

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  24 HSWLSGPLCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFL 103
Cdd:cd15948   1 HPWISIPFCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 104 IHFFSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPD 183
Cdd:cd15948  81 LHSFSIMESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 184 MMRLACADISINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTVHR 263
Cdd:cd15948 161 VVKLACGDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSSTMHR 240

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 52317265 264 FGKHVPCYIHVLMSNVYLFVPPVLNPLIYSAKTKEIR 300
Cdd:cd15948 241 FARHVAPHVHILLANFYLLFPPMMNPIVYGVKTKQIR 277

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

26-299

9.73e-105

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 307.03 E-value: 9.73e-105

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  26 WLSGPLCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIH 105
Cdd:cd15950   2 WIAIPFCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 106 FFSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMM 185
Cdd:cd15950  82 SFTAVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 186 RLACADISINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTVHRFG 265
Cdd:cd15950 162 KLACADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLSIYTQRFG 241

                       250       260       270
                ....*....|....*....|....*....|....
gi 52317265 266 KHVPCYIHVLMSNVYLFVPPVLNPLIYSAKTKEI 299
Cdd:cd15950 242 QGVPPHTQVLLADLYLLVPPMLNPIIYGMRTKQI 275

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

26-303

2.18e-97

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 288.42 E-value: 2.18e-97

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  26 WLSGPLCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIH 105
Cdd:cd15223   2 WLSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 106 FFSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMM 185
Cdd:cd15223  82 FFTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 186 RLACADISINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTVHRFG 265
Cdd:cd15223 162 SLACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLTYRFG 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 52317265 266 KHVPCYIHVLMSNVYLFVPPVLNPLIYSAKTKEIRRAI 303
Cdd:cd15223 242 KTIPPDVHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

26-299

1.74e-89

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 268.18 E-value: 1.74e-89

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  26 WLSGPLCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIH 105
Cdd:cd15955   2 WIGIPFCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 106 FFSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIK-RLPICRSNVLSHSYCLHPDM 184
Cdd:cd15955  82 TLQAFESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVLIIPCPLLIKlRLHHFRSTVISHSYCEHMAV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 185 MRLACADISINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTVHRF 264
Cdd:cd15955 162 VKLAADDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHRF 241

                       250       260       270
                ....*....|....*....|....*....|....*
gi 52317265 265 GKHVPCYIHVLMSNVYLFVPPVLNPLIYSAKTKEI 299
Cdd:cd15955 242 GHHVAPYVHILLSNLYLLVPPVLNPIVYGVKTKQI 276

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

26-299

1.80e-85

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 257.87 E-value: 1.80e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  26 WLSGPLCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIH 105
Cdd:cd15956   2 WLSLPFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 106 FFSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMM 185
Cdd:cd15956  82 AFSAMESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 186 RLACADISINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTVHRFG 265
Cdd:cd15956 162 KLACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRFG 241

                       250       260       270
                ....*....|....*....|....*....|....
gi 52317265 266 KHVPCYIHVLMSNVYLFVPPVLNPLIYSAKTKEI 299
Cdd:cd15956 242 HSVPSAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

26-299

3.31e-84

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 254.75 E-value: 3.31e-84

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  26 WLSGPLCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIH 105
Cdd:cd15954   2 WISIPFCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 106 FFSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMM 185
Cdd:cd15954  82 TFTGMESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 186 RLACADISINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTVHRFG 265
Cdd:cd15954 162 KLACANIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHRFG 241

                       250       260       270
                ....*....|....*....|....*....|....*
gi 52317265 266 KH-VPCYIHVLMSNVYLFVPPVLNPLIYSAKTKEI 299
Cdd:cd15954 242 GHhITPHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

26-293

8.10e-75

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 230.45 E-value: 8.10e-75

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  26 WLSGPLCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIH 105
Cdd:cd13954   2 LLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 106 FFSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMM 185
Cdd:cd13954  82 SLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 186 RLACADISINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTVHRFG 265
Cdd:cd13954 162 KLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSS 241

                       250       260
                ....*....|....*....|....*...
gi 52317265 266 KHVPcyIHVLMSNVYLFVPPVLNPLIYS 293
Cdd:cd13954 242 YSSD--LDKVVSVFYTVVTPMLNPIIYS 267

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

31-303

4.29e-58

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 188.05 E-value: 4.29e-58

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  31 LCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMM 110
Cdd:cd15225   7 FLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFLGGT 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 111 ESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACA 190
Cdd:cd15225  87 ECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVLKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 191 DISINSIYgLFVLVSTFGM-DLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGV------STVHR 263
Cdd:cd15225 167 DTSLNEIA-IFVASVLVILvPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTylrpksSYSPE 245

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 52317265 264 FGKhvpcyihvLMSNVYLFVPPVLNPLIYSAKTKEIRRAI 303
Cdd:cd15225 246 TDK--------LLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

34-303

1.93e-54

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 178.57 E-value: 1.93e-54

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  34 MYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMESG 113
Cdd:cd15235  11 MYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIAFGNTDSF 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 114 ILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADIS 193
Cdd:cd15235  91 LLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLLKLSCSDTS 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 194 INSIY----GLFVLVSTFgmdlFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVstvhrfgkhvp 269
Cdd:cd15235 171 LNELLifteGAVVVLGPF----LLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGV----------- 235

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 52317265 270 cYIHVLMSN----------VYLFVPPVLNPLIYSAKTKEIRRAI 303
Cdd:cd15235 236 -YFQPSSSYsadkdrvatvMYTVVTPMLNPFIYSLRNKDVKGAL 278

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

27-303

1.48e-53

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 176.30 E-value: 1.48e-53

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  27 LSGPLCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHF 106
Cdd:cd15231   3 LFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 107 FSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMR 186
Cdd:cd15231  83 FVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 187 LACADISINSIY----GLFVLVSTFgmdlFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIgvSTVH 262
Cdd:cd15231 163 LSCSDTSLNEVLllvaSVFIGLTPF----LFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAI--FNYN 236

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 52317265 263 RFGKHVPCYIHVLMSNVYLFVPPVLNPLIYSAKTKEIRRAI 303
Cdd:cd15231 237 RPSSGYSLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

33-303

3.71e-53

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 175.09 E-value: 3.71e-53

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15229   9 VIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFAGTEA 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADI 192
Cdd:cd15229  89 FLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLPLSCSDT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 193 SINSIYgLFVLVSTFGM-DLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPmiGVSTVHRFGKHVPCY 271
Cdd:cd15229 169 FANKMV-LLTSSVIFGLgSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGT--GFFRYLRPNSASSSV 245

                       250       260       270
                ....*....|....*....|....*....|..
gi 52317265 272 IHVLMSNVYLFVPPVLNPLIYSAKTKEIRRAI 303
Cdd:cd15229 246 LDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

33-305

6.21e-52

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 172.12 E-value: 6.21e-52

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15411   9 VIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIALATTEC 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADI 192
Cdd:cd15411  89 FLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLKLSCSDT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 193 SINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGV----STVHRFGKhv 268
Cdd:cd15411 169 HVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTylrpSSSYSLGQ-- 246

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 52317265 269 pcyiHVLMSNVYLFVPPVLNPLIYSAKTKEIRRAIFR 305
Cdd:cd15411 247 ----DKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

26-293

7.70e-52

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 171.79 E-value: 7.70e-52

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  26 WLSGPLCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIH 105
Cdd:cd15914   2 LLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 106 FFSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMM 185
Cdd:cd15914  82 SLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 186 RLACADISINS----IYGLFVLVSTFgmdlFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIgvSTV 261
Cdd:cd15914 162 SLACTDTSLNVlvdfVIHAVIILLTF----LLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVS--FMY 235

                       250       260       270
                ....*....|....*....|....*....|..
gi 52317265 262 HRFGKHVPCYIHVLMSNVYLFVPPVLNPLIYS 293
Cdd:cd15914 236 LRLSKSYSLDYDRAIAVVYAVLTPFFNPIIYS 267

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

31-302

1.69e-51

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 170.81 E-value: 1.69e-51

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  31 LCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMM 110
Cdd:cd15421   7 ILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLTLGGA 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 111 ESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACA 190
Cdd:cd15421  87 ECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLKLSCA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 191 DIsinSIYGLFVLVSTFGMDLF---FIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTVHRfGKH 267
Cdd:cd15421 167 DT---SAYETVVYVSGVLFLLIpfsLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPG-SYH 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 52317265 268 VPCYIHVLmSNVYLFVPPVLNPLIYSAKTKEIRRA 302
Cdd:cd15421 243 SPEQDKVV-SVFYTILTPMLNPLIYSLRNKEVLGA 276

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

27-293

4.96e-51

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 169.59 E-value: 4.96e-51

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  27 LSGPLCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHF 106
Cdd:cd15912   3 LFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 107 FSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMR 186
Cdd:cd15912  83 LGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 187 LACADIS----INSIYGLFVLVSTfgmdLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTvh 262
Cdd:cd15912 163 LSCSDTRlielLDFILASVVLLGS----LLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYV-- 236

                       250       260       270
                ....*....|....*....|....*....|.
gi 52317265 263 RFGKHVPCYIHVLMSNVYLFVPPVLNPLIYS 293
Cdd:cd15912 237 RPSQSSSLDLNKVVALLNTVVTPLLNPFIYT 267

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

33-293

2.80e-50

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 167.68 E-value: 2.80e-50

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15230   9 LIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFGTTEC 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADI 192
Cdd:cd15230  89 FLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLLKLSCSDT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 193 SINSIYgLFVLVSTFGM-DLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIgVSTVHRFGKHVPCY 271
Cdd:cd15230 169 HINELV-LFAFSGFIGLsTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLI-FMYLRPSSSYSLDQ 246

                       250       260
                ....*....|....*....|..
gi 52317265 272 IHVlMSNVYLFVPPVLNPLIYS 293
Cdd:cd15230 247 DKV-VSVFYTVVIPMLNPLIYS 267

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

33-305

6.99e-50

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 166.81 E-value: 6.99e-50

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15412   9 VIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIALVITEY 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADI 192
Cdd:cd15412  89 YMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLIKLSCSDT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 193 SINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGV------STVHRFGK 266
Cdd:cd15412 169 YVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMylrppsEESVEQSK 248

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 52317265 267 HVPCYihvlmsnvYLFVPPVLNPLIYSAKTKEIRRAIFR 305
Cdd:cd15412 249 IVAVF--------YTFVSPMLNPLIYSLRNKDVKQALKK 279

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

33-302

1.57e-49

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 165.96 E-value: 1.57e-49

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15420   9 LLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLALAHTEC 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADI 192
Cdd:cd15420  89 VLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLKLACADT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 193 SINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTVHRFGKhvPCYI 272
Cdd:cd15420 169 WINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSN--SAEQ 246

                       250       260       270
                ....*....|....*....|....*....|
gi 52317265 273 HVLMSNVYLFVPPVLNPLIYSAKTKEIRRA 302
Cdd:cd15420 247 EKILSLFYSLFNPMLNPLIYSLRNKQVKGA 276

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

33-293

2.70e-49

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 164.93 E-value: 2.70e-49

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15227   9 LIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFFAASEL 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFI-------TLFPLPFlikrlpiCRSNVLSHSYCLHPDMM 185
Cdd:cd15227  89 ALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLygalhtaNTFSLPF-------CGSNVIHQFFCDIPQLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 186 RLACADISINsIYGLFVLVSTFGMDLF-FIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPmiGVSTVHRF 264
Cdd:cd15227 162 KLSCSDTYLN-EIGVLVLSVCLGLGCFvFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLST--GSFAYLKP 238

                       250       260
                ....*....|....*....|....*....
gi 52317265 265 GKHVPCYIHVLMSNVYLFVPPVLNPLIYS 293
Cdd:cd15227 239 PSDSPSLLDLLLSVFYSVVPPTLNPIIYS 267

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

12-300

4.02e-49

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 165.19 E-value: 4.02e-49

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  12 FLLTGIPGLESSHSWLSGPLCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARN 91
Cdd:cd15408   1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  92 ITFDACLIQMFLIHFFSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRS 171
Cdd:cd15408  81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 172 NVLSHSYCLHPDMMRLACADISINSIYgLFVLVS-TFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLA 250
Cdd:cd15408 161 NVINHFFCDGPPLLALSCSDTSLNEML-LFAFVGfNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTL 239

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 52317265 251 FYvpmigVSTVHRFGKHVPCYIHVLM---SNVYLFVPPVLNPLIYSAKTKEIR 300
Cdd:cd15408 240 FY-----GSLAFMYLRPSSRYSLDLDkvaSVFYTVVIPMLNPLIYSLRNKEVK 287

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

33-305

6.35e-49

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 164.35 E-value: 6.35e-49

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15417   9 GIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGMGLTEC 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADI 192
Cdd:cd15417  89 FLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLLSLSCSDT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 193 SINSIYgLFVLVSTFGM-DLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVsTVHRFGKHVPCY 271
Cdd:cd15417 169 FISQVV-LFLVAVLFGVfSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFV-YLRPSSSHSQDQ 246

                       250       260       270
                ....*....|....*....|....*....|....
gi 52317265 272 IHVLmSNVYLFVPPVLNPLIYSAKTKEIRRAIFR 305
Cdd:cd15417 247 DKVA-SVFYTVVIPMLNPLIYSLRNKEIKDALKR 279

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

33-293

8.93e-49

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 163.60 E-value: 8.93e-49

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15237   9 LIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLALGVTEC 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADI 192
Cdd:cd15237  89 VLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVLKLACADT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 193 SINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGV------STVHRFGK 266
Cdd:cd15237 169 SLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMymrphsTHSPDQDK 248

                       250       260
                ....*....|....*....|....*..
gi 52317265 267 HVPCYihvlmsnvYLFVPPVLNPLIYS 293
Cdd:cd15237 249 MISVF--------YTIVTPMLNPLIYS 267

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

34-293

1.03e-48

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 163.55 E-value: 1.03e-48

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  34 MYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMESG 113
Cdd:cd15918  10 MYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFGDLDNF 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 114 ILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYC-LHPdMMRLACADI 192
Cdd:cd15918  90 LLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCdLNP-LLKLSCSDT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 193 SINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGV----STVHRFGKhv 268
Cdd:cd15918 169 HLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVylspPSSHSASK-- 246

                       250       260
                ....*....|....*....|....*
gi 52317265 269 pcyiHVLMSNVYLFVPPVLNPLIYS 293
Cdd:cd15918 247 ----DSVAAVMYTVVTPMLNPFIYS 267

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

31-293

2.52e-48

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 162.39 E-value: 2.52e-48

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  31 LCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMM 110
Cdd:cd15431   7 LLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFLGIT 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 111 ESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFpLPFLIKRLPICRSNVLSHSYCLHPDMMRLACA 190
Cdd:cd15431  87 ECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTV-IPVLTMPLHFCGPNVINHFFCEVQALLKLACS 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 191 DISINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGV------STVHRF 264
Cdd:cd15431 166 DTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMylrpqsKSSSDQ 245

                       250       260
                ....*....|....*....|....*....
gi 52317265 265 GKhvpcyihvLMSNVYLFVPPVLNPLIYS 293
Cdd:cd15431 246 DK--------IISVFYGVVTPMLNPLIYS 266

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

12-307

5.48e-48

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 162.44 E-value: 5.48e-48

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  12 FLLTGIpgleSSHSWLSGPLCV----MYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCL 87
Cdd:cd15410   1 FILLGF----TDYPELQVPLFLvflaIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLA 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  88 NARNITFDACLIQMFLIHFFSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLP 167
Cdd:cd15410  77 EDKAISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLS 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 168 ICRSNVLSHSYCLHPDMMRLACADISIN----SIYGLFVLVSTFGMdlffIFLSYVLILRSVMATASREERLKALNTCVS 243
Cdd:cd15410 157 FCGSNVINHFFCDLPPLLSLSCSDTYLNelllFIFGSLNEASTLLI----ILTSYVFIIVTILRIRSAEGRQKAFSTCAS 232

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 52317265 244 HILAVLAFYVPMIgvstvhrFGKHVPCYIHVL----MSNV-YLFVPPVLNPLIYSAKTKEIRRAIFRMF 307
Cdd:cd15410 233 HLTAITIFHGTIL-------FMYCRPSSSYSLdtdkVASVfYTVVIPMLNPLIYSLRNKDVKDALRKLI 294

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

33-305

5.81e-48

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 161.77 E-value: 5.81e-48

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15416   9 VIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATFGTVEC 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADI 192
Cdd:cd15416  89 FLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLKLSCSDI 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 193 SINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTVHRFGKHVPcyI 272
Cdd:cd15416 169 RLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSYSMD--Q 246

                       250       260       270
                ....*....|....*....|....*....|...
gi 52317265 273 HVLMSNVYLFVPPVLNPLIYSAKTKEIRRAIFR 305
Cdd:cd15416 247 NKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

34-303

1.16e-47

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 161.21 E-value: 1.16e-47

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  34 MYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMESG 113
Cdd:cd15234  10 MYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLFGGLDNF 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 114 ILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADIS 193
Cdd:cd15234  90 LLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLKLACSDTL 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 194 INSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGV---STVHRFGKHVpc 270
Cdd:cd15234 170 INNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVyisSAVTHSSRKT-- 247

                       250       260       270
                ....*....|....*....|....*....|...
gi 52317265 271 yihVLMSNVYLFVPPVLNPLIYSAKTKEIRRAI 303
Cdd:cd15234 248 ---AVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

33-293

1.53e-47

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 160.55 E-value: 1.53e-47

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15915   9 LLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFLGSSEA 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADI 192
Cdd:cd15915  89 MLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLKLACGDT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 193 SIN----SIYGLFVLVSTFgmdlFFIFLSYVLILRSVM-ATASREERLKALNTCVSHILAVLAFYVPMIGVSTVHRFGKH 267
Cdd:cd15915 169 SLNlwllNIVTGSIALGTF----ILTLLSYIYIISFLLlKVRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSGDS 244

                       250       260
                ....*....|....*....|....*.
gi 52317265 268 VPcyIHVLMSNVYLFVPPVLNPLIYS 293
Cdd:cd15915 245 LE--QDRIVALLYTVVTPVLNPLIYT 268

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

33-293

2.02e-47

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 160.07 E-value: 2.02e-47

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15939   9 LIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFFGGAEI 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYC-LHPdMMRLACAD 191
Cdd:cd15939  89 FLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCdLFP-LLKLACTD 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 192 IsinSIYGLFVLVSTFGMDL--FFIFL-SYVLILRSvMATASREERLKALNTCVSHILAVLAFYVPMI-----GVSTVHr 263
Cdd:cd15939 168 T---YVIGLLVVANSGLICLlsFLILLiSYIVILYS-LRTHSSEGRRKALSTCGSHITVVVLFFVPCIfiymrPVTTFP- 242

                       250       260       270
                ....*....|....*....|....*....|
gi 52317265 264 fgkhvpcyIHVLMSNVYLFVPPVLNPLIYS 293
Cdd:cd15939 243 --------IDKVVAVFYTIITPMLNPLIYT 264

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

33-307

2.54e-47

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 160.61 E-value: 2.54e-47

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15943  23 VIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKTISFTGCAAQMYFFVAFATTEC 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADI 192
Cdd:cd15943 103 FLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCGSNVINHFFCDVPPLLKLSCSDT 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 193 SINSIYgLFVLVSTFGMDLFF-IFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVpmigvSTVHRFGKHVPCY 271
Cdd:cd15943 183 HVNEIV-LFAFAIFLGIFTSLeILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTIFYG-----TTLFMYLRPSSSY 256

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 52317265 272 I---HVLMSNVYLFVPPVLNPLIYSAKTKEIRRAIFRMF 307
Cdd:cd15943 257 SldqDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

27-292

1.22e-46

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 158.17 E-value: 1.22e-46

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  27 LSGPLCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHF 106
Cdd:cd15947   3 LFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLW 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 107 FSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMR 186
Cdd:cd15947  83 LGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 187 LACADISINSIyGLFVLVSTFGM-DLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGV------S 259
Cdd:cd15947 163 LACVDTTFNEL-ELFVASVFFLLvPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMylqppsS 241

                       250       260       270
                ....*....|....*....|....*....|...
gi 52317265 260 TVHRFGKhvpcyihvLMSNVYLFVPPVLNPLIY 292
Cdd:cd15947 242 YSQDQGK--------FISLFYTVVTPTLNPLIY 266

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

33-303

1.80e-46

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 158.00 E-value: 1.80e-46

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFC-LNARNITFDACLIQMFLIHFFSMME 111
Cdd:cd15916   9 IIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLePGGKVISFGGCVAQLYFFHFLGSTE 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 112 SGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACAD 191
Cdd:cd15916  89 CFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLLKLACAD 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 192 ISINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPmiGVSTVHRFGKHVPcy 271
Cdd:cd15916 169 TTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVP--CVFIYLRPGSKEA-- 244

                       250       260       270
                ....*....|....*....|....*....|..
gi 52317265 272 IHVLMSNVYLFVPPVLNPLIYSAKTKEIRRAI 303
Cdd:cd15916 245 LDGVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

33-302

3.19e-46

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 157.18 E-value: 3.19e-46

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15429   9 VMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLALGGTEF 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADI 192
Cdd:cd15429  89 ILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVRLACVDT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 193 SINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIgvSTVHRFGKHVPCYI 272
Cdd:cd15429 169 SLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAI--FTYMRPRSGSSALQ 246

                       250       260       270
                ....*....|....*....|....*....|
gi 52317265 273 HVLMSNVYLFVPPVLNPLIYSAKTKEIRRA 302
Cdd:cd15429 247 EKMISLFYAVVTPMLNPLIYSLRNKEVKGA 276

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

33-303

1.65e-45

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 155.71 E-value: 1.65e-45

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15432   9 IFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLGLGSTEC 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADI 192
Cdd:cd15432  89 VLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLKLSCVDT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 193 SINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGV------STVHRFGK 266
Cdd:cd15432 169 TANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMylqppsNSSHDRGK 248

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 52317265 267 hvpcyihvLMSNVYLFVPPVLNPLIYSAKTKEIRRAI 303
Cdd:cd15432 249 --------MVALFYGIITPMLNPLIYTLRNKDVKEAL 277

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

33-303

1.76e-45

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 155.28 E-value: 1.76e-45

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15228   9 AFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFLGSTEC 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADI 192
Cdd:cd15228  89 LLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLKLACADT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 193 SINSIYGlFVLVSTFGMDLFF-IFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTvhrfgkhVPCY 271
Cdd:cd15228 169 SIAETVS-FTNVGLVPLTCFLlILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYT-------QPTP 240

                       250       260       270
                ....*....|....*....|....*....|....*
gi 52317265 272 IHVLMSNVYLF---VPPVLNPLIYSAKTKEIRRAI 303
Cdd:cd15228 241 SPVLVTPVQIFnnvVTPMLNPLIYTLRNKEVKAAL 275

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

12-305

5.18e-45

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 154.52 E-value: 5.18e-45

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  12 FLLTGIPGLESSHSWLSGPLCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARN 91
Cdd:cd15945   1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  92 ITFDACLIQMFLIHFFSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRS 171
Cdd:cd15945  81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 172 NVLSHSYCLHPDMMRLACADISINSIYgLFVLVSTFGMDLFF-IFLSYVLILRSVMATASREERLKALNTCVSHILAVLA 250
Cdd:cd15945 161 NTINHFFCDIPPLLALSCSDTQINELL-LFALCGFIQTSTFLaIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGL 239

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 251 FYVPMIgvstvhrFGKHVPCYIHVL----MSNV-YLFVPPVLNPLIYSAKTKEIRRAIFR 305
Cdd:cd15945 240 FYGTLL-------FMYLRPSSSYSLdtdkMTSVfYTLVIPMLNPLIYSLRNKDVKEALKK 292

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

30-293

7.46e-45

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 153.68 E-value: 7.46e-45

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  30 PLC-VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFS 108
Cdd:cd15430   5 VLClIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAMG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 109 MMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLA 188
Cdd:cd15430  85 STECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVLKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 189 CADISINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTVHRFGKHV 268
Cdd:cd15430 165 CVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSKNAQ 244

                       250       260
                ....*....|....*....|....*
gi 52317265 269 PcyIHVLMSNVYLFVPPVLNPLIYS 293
Cdd:cd15430 245 I--SDKLITLFYGVVTPMLNPIIYS 267

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

33-305

9.48e-45

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 153.72 E-value: 9.48e-45

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15415   9 LIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFVTTEG 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADI 192
Cdd:cd15415  89 FLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKLSCSDT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 193 SINSIYgLFVLVSTFGM-DLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPM----IGVSTVHRFGKH 267
Cdd:cd15415 169 HINELL-LLTFSGVIAMsTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVsfsyIQPSSQYSLEQE 247

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 52317265 268 VPCYIhvlmsnVYLFVPPVLNPLIYSAKTKEIRRAIFR 305
Cdd:cd15415 248 KVSAV------FYTLVIPMLNPLIYSLRNKDVKDALKR 279

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

33-293

1.47e-44

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 152.64 E-value: 1.47e-44

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15911   9 VIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSLAATEC 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADI 192
Cdd:cd15911  89 YLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLKLSCSDT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 193 SINSIYgLFVLVSTFGMDLF-FIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTVHRFGKhvPCY 271
Cdd:cd15911 169 SLVELV-TFILSSIVTLPPFlLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTNT--SRD 245

                       250       260
                ....*....|....*....|..
gi 52317265 272 IHVLMSNVYLFVPPVLNPLIYS 293
Cdd:cd15911 246 LNKVFSLFYTVLTPLVNPLIYS 267

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

33-305

2.75e-44

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 152.46 E-value: 2.75e-44

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15419   9 VIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLFGTTEG 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADI 192
Cdd:cd15419  89 FLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLLKLSCSDT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 193 SINSIYGL----FVLVSTFgmdlFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYvpmigvSTVHrFGKHV 268
Cdd:cd15419 169 FINELVMFvlcgLIIVSTI----LVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFY------GTVF-FMYAQ 237

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 52317265 269 PCYIHV-----LMSNVYLFVPPVLNPLIYSAKTKEIRRAIFR 305
Cdd:cd15419 238 PGAVSSpeqskVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

33-293

5.05e-44

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 151.26 E-value: 5.05e-44

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15232   9 FLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWSLGSEL 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADI 192
Cdd:cd15232  89 LLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLLLLSCSDT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 193 SINSIYgLFVLVSTFGMDLF-FIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGV----STVHRFGKh 267
Cdd:cd15232 169 SLNEIM-AFVADVFFGVGNFlLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTyirpSSSYSPEK- 246

                       250       260
                ....*....|....*....|....*.
gi 52317265 268 vpcyiHVLMSNVYLFVPPVLNPLIYS 293
Cdd:cd15232 247 -----DKVVAVLYSVVTPTLNPLIYS 267

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

33-307

8.58e-44

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 151.42 E-value: 8.58e-44

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15414   9 LVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLFVAAEC 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADI 192
Cdd:cd15414  89 FLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLLSLSCADT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 193 SINSIYgLFVLVSTFG-MDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTvhRFGKHVPCY 271
Cdd:cd15414 169 QINKWV-LFIMAGALGvLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYV--RPSSSSSLD 245

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 52317265 272 IHVLMSNVYLFVPPVLNPLIYSAKTKEIRRAIFRMF 307
Cdd:cd15414 246 LDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTI 281

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

33-303

1.01e-43

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 150.66 E-value: 1.01e-43

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15942   9 VVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFLGCAEC 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADI 192
Cdd:cd15942  89 FLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLKLACADT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 193 SINSIYgLFVLVSTFGMDLF-FIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIgvstvhrFGKHVPCY 271
Cdd:cd15942 169 AFNELV-TFIDIGLVAMTCFlLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLT-------FIYLRPGS 240

                       250       260       270
                ....*....|....*....|....*....|....*
gi 52317265 272 IHVLMSNVYLF---VPPVLNPLIYSAKTKEIRRAI 303
Cdd:cd15942 241 QDPLDGVVAVFyttVTPLLNPVIYTLRNKEMKDAL 275

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

33-302

1.69e-43

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 150.26 E-value: 1.69e-43

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15407   9 LIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVFATVEN 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADI 192
Cdd:cd15407  89 FLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLALSCSDI 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 193 SINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGV----STVHRFGKhv 268
Cdd:cd15407 169 HISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMylqpSSSHSMDT-- 246

                       250       260       270
                ....*....|....*....|....*....|....
gi 52317265 269 pcyiHVLMSNVYLFVPPVLNPLIYSAKTKEIRRA 302
Cdd:cd15407 247 ----DKMASVFYTMVIPMLNPLVYSLRNKEVKSA 276

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

9-306

1.73e-43

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 150.60 E-value: 1.73e-43

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265   9 PAFFLLTGIpglesshswlsgplcvmYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLN 88
Cdd:cd15406  11 PLFLLFLGI-----------------YVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSE 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  89 ARNITFDACLIQMFLIHFFSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPI 168
Cdd:cd15406  74 KNIISYPECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSF 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 169 CRSNVLSHSYCLHPDMMRLACADISINSIYGLF-----VLVSTFGmdlffIFLSYVLILRSVMATASREERLKALNTCVS 243
Cdd:cd15406 154 CGDNVINHYFCDILPLLKLSCSSTYINELLLFIvggfnVLATTLA-----ILISYAFILSSILRIRSAEGRSKAFSTCSS 228

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 52317265 244 HILAVLAFYVPMIGV----STVHRFGKHVpcyihvLMSNVYLFVPPVLNPLIYSAKTKEIRRAIFRM 306
Cdd:cd15406 229 HLAAVGVFYGSIIFMylkpSSSSSMTQEK------VSSVFYTTVIPMLNPLIYSLRNKDVKNALKKV 289

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

33-293

7.37e-43

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 148.36 E-value: 7.37e-43

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15940   9 VLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFACTEI 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADI 192
Cdd:cd15940  89 FLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIKLACTDT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 193 SINSIyglfVLVSTFGMDLFFIFL----SYVLILRSVMaTASREERLKALNTCVSHILAVLAFYVPMIGVSTvhRFGKHV 268
Cdd:cd15940 169 YLIDI----LIVSNSGLISLVCFVallgSYIVILVSLR-KRSTEGRRKALSTCASHLTVVTLFFGPCIFIYT--RPSTSF 241

                       250       260
                ....*....|....*....|....*
gi 52317265 269 PcyIHVLMSNVYLFVPPVLNPLIYS 293
Cdd:cd15940 242 S--EDKVVSVFYTVVTPLLNPIIYT 264

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

33-305

7.99e-43

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 148.71 E-value: 7.99e-43

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15409   9 AIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSATTEC 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADI 192
Cdd:cd15409  89 FLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLLKISCTDP 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 193 SINS----IYGLFVLVSTFGMdlffIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTVHRFGKHV 268
Cdd:cd15409 169 SINElvlfIFSGSIQVFTILT----VLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSLYAL 244

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 52317265 269 pcYIHVLMSNVYLFVPPVLNPLIYSAKTKEIRRAIFR 305
Cdd:cd15409 245 --DQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

27-305

1.64e-42

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 147.85 E-value: 1.64e-42

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  27 LSGPLCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHF 106
Cdd:cd15413   3 LFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 107 FSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMR 186
Cdd:cd15413  83 FIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLA 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 187 LACADISINSIygLFVLVSTFGM--DLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIgvstvhrF 264
Cdd:cd15413 163 LSCSDTHEKEL--IILIFAGFNLisSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLI-------F 233

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 52317265 265 GKHVPCYIHVL----MSNV-YLFVPPVLNPLIYSAKTKEIRRAIFR 305
Cdd:cd15413 234 MYLQPKSSHSLdtdkMASVfYTLVIPMLNPLIYSLRNKEVKDALKK 279

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

35-303

3.82e-42

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 146.86 E-value: 3.82e-42

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  35 YAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMESGI 114
Cdd:cd15233  11 YIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHLLAGADCFL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 115 LLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADISI 194
Cdd:cd15233  91 LTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQLSCSSTHL 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 195 NSIYgLFVLVSTFGM-DLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYvpMIGVSTVHRFGKHVPCYIH 273
Cdd:cd15233 171 NELL-LFVFAFFMALaPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFY--GTGVFSYMRLGSVYSSDKD 247

                       250       260       270
                ....*....|....*....|....*....|
gi 52317265 274 VLMSNVYLFVPPVLNPLIYSAKTKEIRRAI 303
Cdd:cd15233 248 KVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

32-293

9.43e-42

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 145.42 E-value: 9.43e-42

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  32 CVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMME 111
Cdd:cd15226   8 SLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHFFGGSE 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 112 SGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFI-TLFPLPFLIKrLPICRSNVLSHSYCLHPDMMRLACA 190
Cdd:cd15226  88 MVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIhSLSQLAFVVN-LPFCGPNVVDSFFCDLPLVIKLACT 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 191 D-----ISINSIYGLFVLVStfgmdLFFIFLSYVLILRSVMaTASREERLKALNTCVSHILAVLAFYVPMIGVSTVHRFG 265
Cdd:cd15226 167 DtyvleLMVVANSGLISLVC-----FLLLLISYIVILVTVR-KHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFST 240

                       250       260
                ....*....|....*....|....*...
gi 52317265 266 KHVPCYIHVLmsnvYLFVPPVLNPLIYS 293
Cdd:cd15226 241 FPVDKFLAVF----YTVITPLLNPIIYT 264

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

33-303

8.08e-41

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 143.33 E-value: 8.08e-41

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15405   9 GIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFFVISEC 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADI 192
Cdd:cd15405  89 YVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQLSCTST 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 193 SINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFyvpmigvstvhrFGKHVPCYI 272
Cdd:cd15405 169 YVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLF------------FGSGAFMYL 236

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 52317265 273 HV----------LMSNVYLFVPPVLNPLIYSAKTKEIRRAI 303
Cdd:cd15405 237 KPssvgsvnqgkVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

35-293

5.15e-40

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 140.93 E-value: 5.15e-40

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  35 YAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMESGI 114
Cdd:cd15936  11 YLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTGGAEVFL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 115 LLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADISI 194
Cdd:cd15936  91 LSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIKLACTDTFL 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 195 NSIyglfVLVSTFGMDLFFIFL----SYVLILRSVMaTASREERLKALNTCVSHILAVLAFYVPMIGVSTvhRFGKHVPc 270
Cdd:cd15936 171 LEL----LMVSNSGLVTLLIFFilliSYTVILVKIR-THVTEGKRKALSTCASQITVVTLIFVPCIYIYA--RPFQTFP- 242

                       250       260
                ....*....|....*....|...
gi 52317265 271 yIHVLMSNVYLFVPPVLNPLIYS 293
Cdd:cd15936 243 -MDKAVSVLYTVITPMLNPMIYT 264

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

33-292

6.75e-40

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 140.50 E-value: 6.75e-40

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15224   9 IAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSLACTEC 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADI 192
Cdd:cd15224  89 VLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLNLSCTDM 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 193 S----INSIYGLFVLVstfgMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIgvstvhrFGKHV 268
Cdd:cd15224 169 SlaelVDFILALIILL----VPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATL-------FMYAR 237

                       250       260
                ....*....|....*....|....*....
gi 52317265 269 PCYIHVLMSN-----VYLFVPPVLNPLIY 292
Cdd:cd15224 238 PKAISSFDSNklvsvLYTVVTPLLNPIIY 266

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

34-303

1.42e-39

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 139.90 E-value: 1.42e-39

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  34 MYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMESG 113
Cdd:cd15236  10 MYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFFGCLDSF 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 114 ILLAMSFDRYVAICDPLRYATVLTTEViaAMGLGAAARSFITLFPL--PFLIKRLPICRSNVLSHSYCLHPDMMRLACAD 191
Cdd:cd15236  90 LLAVMAYDRYVAICHPLHYTAIMRPEL--CVLLVAGSWVLTCFHALlhTLLLARLSFCADNVIPHFFCDLVALLKLSCSS 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 192 ISINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTVHRFGKHVPCY 271
Cdd:cd15236 168 TSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNSSDKD 247

                       250       260       270
                ....*....|....*....|....*....|..
gi 52317265 272 IhvLMSNVYLFVPPVLNPLIYSAKTKEIRRAI 303
Cdd:cd15236 248 I--VASVMYTVVTPMLNPFIYSLRNRDIKGAL 277

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

27-303

2.24e-39

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 139.44 E-value: 2.24e-39

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  27 LSGPLCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHF 106
Cdd:cd15434   3 LSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALG 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 107 FSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMR 186
Cdd:cd15434  83 LGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 187 LACADISINSIYgLFVL-VSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMI------GVS 259
Cdd:cd15434 163 LACVDTTAYEAT-IFALgVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIymylqpKNS 241

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 52317265 260 TVHRFGKhvpcyihvLMSNVYLFVPPVLNPLIYSAKTKEIRRAI 303
Cdd:cd15434 242 VSQDQGK--------FLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

33-303

3.82e-39

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 138.77 E-value: 3.82e-39

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15428   9 IIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLSFGITEC 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADI 192
Cdd:cd15428  89 ALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLKLASTDT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 193 S----INSIYGLFVLVstfgMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPmiGVSTVHRFGKHV 268
Cdd:cd15428 169 HqaemAMFIMCVFTLV----LPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGS--VLSTYMRPKSST 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 52317265 269 PCYIHVLMSNVYLFVPPVLNPLIYSAKTKEIRRAI 303
Cdd:cd15428 243 SKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

33-293

6.53e-39

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 138.00 E-value: 6.53e-39

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15946   9 LIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLALGITEC 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADI 192
Cdd:cd15946  89 TLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLKLACADT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 193 SINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMI------GVSTVHRFGK 266
Cdd:cd15946 169 SLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMfmymrpGSNYSPERDK 248

                       250       260
                ....*....|....*....|....*..
gi 52317265 267 HvpcyihvlMSNVYLFVPPVLNPLIYS 293
Cdd:cd15946 249 K--------ISLFYNVFTALLNPVIYS 267

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

33-303

7.88e-39

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 137.94 E-value: 7.88e-39

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15424   9 IIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALSLGSTEC 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADI 192
Cdd:cd15424  89 LLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLKLACADT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 193 SINS--IYGLFVLVSTFgmDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTVHRFGKhvPC 270
Cdd:cd15424 169 HITEaiVFGAGVLILLV--PLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGS--TP 244

                       250       260       270
                ....*....|....*....|....*....|...
gi 52317265 271 YIHVLMSNVYLFVPPVLNPLIYSAKTKEIRRAI 303
Cdd:cd15424 245 DRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

33-293

2.18e-38

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 136.68 E-value: 2.18e-38

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLihFFSM--M 110
Cdd:cd15913   9 VIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYF--FFSLgtT 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 111 ESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFItLFPLP-FLIKRLPICRSNVLSHSYCLHPDMMRLAC 189
Cdd:cd15913  87 ECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFL-WFLIPvVLISQLPFCGPNIIDHFLCDPGPLLALSC 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 190 ADIS-INSIYGLFVLVSTFGmDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTVHRFGKHV 268
Cdd:cd15913 166 VPAPgTELICYTLSSLIIFG-TFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSGNST 244

                       250       260
                ....*....|....*....|....*
gi 52317265 269 PcyIHVLMSNVYLFVPPVLNPLIYS 293
Cdd:cd15913 245 G--MQKIVTLFYSVVTPLLNPLIYS 267

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

33-307

1.15e-37

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 135.68 E-value: 1.15e-37

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15944  22 IIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKVISFSGCATQFAFFVGFVDAEC 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADI 192
Cdd:cd15944 102 YVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGSNIINHFFCDVPPLLALSCSDT 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 193 SINSI----YGLFVLVSTFGMdlffIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIgvstvhrFGKHV 268
Cdd:cd15944 182 HINEIllyvFCGFVEMSSLSI----ILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLFYGTVI-------FMYLR 250

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 52317265 269 PCYIHVL-----MSNVYLFVPPVLNPLIYSAKTKEIRRAIFRMF 307
Cdd:cd15944 251 PTSVYSLdqdkwASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

27-293

2.43e-37

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 134.12 E-value: 2.43e-37

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  27 LSGPLCVMYAVALGGNTVILQAVRVEPSLHE-PMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIH 105
Cdd:cd15935   3 LFVLVLACYAAILLGNLLIVVTVHADPHLLQsPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLH 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 106 FFSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMM 185
Cdd:cd15935  83 FLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQVI 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 186 RLACADISINSIyglfVLVSTFGMDLFFIFL----SYVLILRSVmATASREERLKALNTCVSHILAVLAFYVPMIGVSTV 261
Cdd:cd15935 163 KLACMDTYVVEV----LMVANSGLLSLVCFLvllvSYGIILTTL-RGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLR 237

                       250       260       270
                ....*....|....*....|....*....|..
gi 52317265 262 HRFGKHVpcyiHVLMSNVYLFVPPVLNPLIYS 293
Cdd:cd15935 238 PFSSSSV----DKVASVFYTLITPALNPLIYT 265

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

33-303

9.40e-37

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 132.66 E-value: 9.40e-37

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHE-PMYYFLSMLSFSDVAISMATLPTVLRTF-CLNARNITFDACLIQMFLIHFFSMM 110
Cdd:cd15941   9 LIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLlTLSGRTISFEGCVVQLYAFHFLAST 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 111 ESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACA 190
Cdd:cd15941  89 ECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPVLKLACA 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 191 DISINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTVHRFGKHVPC 270
Cdd:cd15941 169 DTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSSSQAGAG 248

                       250       260       270
                ....*....|....*....|....*....|...
gi 52317265 271 YIHVLmsnvYLFVPPVLNPLIYSAKTKEIRRAI 303
Cdd:cd15941 249 APAVF----YTIVTPMLNPFIYTLRNKEVKRAL 277

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

33-303

1.07e-35

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 129.91 E-value: 1.07e-35

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15433   9 IFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLALGSAEC 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADI 192
Cdd:cd15433  89 VLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLKLACGDD 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 193 SINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGV------STVHRFGK 266
Cdd:cd15433 169 ETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTylqpihRYSQAHGK 248

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 52317265 267 HVPCYihvlmsnvYLFVPPVLNPLIYSAKTKEIRRAI 303
Cdd:cd15433 249 FVSLF--------YTVMTPALNPLIYTLRNKDVKGAL 277

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

35-295

1.62e-35

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 129.22 E-value: 1.62e-35

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  35 YAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMESGI 114
Cdd:cd15938  11 YTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFVGAAEMFL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 115 LLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADISI 194
Cdd:cd15938  91 LTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIKLACTDTCV 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 195 NSiyglFVLVSTFGMDLFFIFL----SYVLILRSVMataSREERLKALNTCVSHILAVLAFYVPMIGVSTvhRFGKHVPC 270
Cdd:cd15938 171 TE----LLMVSNSGLISTVCFVvlvtSYTTILVTIR---STEGRRKALSTCASHLMVVTLFFGPCIFIYA--RPFSTFPV 241

                       250       260
                ....*....|....*....|....*
gi 52317265 271 YIHVlmSNVYLFVPPVLNPLIYSAK 295
Cdd:cd15938 242 DKHV--SVLYNVITPMLNPLIYTLR 264

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

33-303

8.49e-34

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 124.89 E-value: 8.49e-34

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15418  10 LSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSAGLAYSEC 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADI 192
Cdd:cd15418  90 FLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLVKLACDDT 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 193 SINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTVHRfGKHVPCYI 272
Cdd:cd15418 170 RVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPS-SSHTPDRD 248

                       250       260       270
                ....*....|....*....|....*....|.
gi 52317265 273 HVlMSNVYLFVPPVLNPLIYSAKTKEIRRAI 303
Cdd:cd15418 249 KV-VALFYTVVNPLLNPLIYSLRNKDVKEAL 278

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

35-256

8.66e-32

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 119.46 E-value: 8.66e-32

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  35 YAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMESGI 114
Cdd:cd15937  11 YLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHFLGAAEMFL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 115 LLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADISI 194
Cdd:cd15937  91 LVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVIKLACTNTYT 170

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 52317265 195 NSIyglfVLVSTFGMDLFFIFL----SYVLILrSVMATASREERLKALNTCVSHILAVLAFYVPMI 256
Cdd:cd15937 171 VEL----LMFSNSGLVILLCFLllliSYAFLL-AKLRTHSSKGKSKAASTCITHIIIVFVMFGPAI 231

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

41-292

9.78e-22

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 91.98 E-value: 9.78e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265    41 GNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDA-CLIQMFLIHFFSMMESGILLAMS 119
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDWPFGSAlCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265   120 FDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRlpiCRSNVLSHSYCLHPDMMRLACadisiNSIYG 199
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWT---LTVPEGNVTVCFIDFPEDLSK-----PVSYT 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265   200 LFVLVSTFGMDLFFIFLSYVLILRSVMATASREERL-------KALNTCVSHILAVLAFYVPMIGVSTVHRFGKHVPCYI 272
Cdd:pfam00001 153 LLISVLGFLLPLLVILVCYTLIIRTLRKSASKQKSSertqrrrKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSR 232

                         250       260
                  ....*....|....*....|....
gi 52317265   273 HV----LMSNVYLFVPPVLNPLIY 292
Cdd:pfam00001 233 LLdkalSVTLWLAYVNSCLNPIIY 256

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

31-295

2.86e-17

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 80.03 E-value: 2.86e-17

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  31 LCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMM 110
Cdd:cd00637   5 YILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSLLA 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 111 ESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMrlaca 190
Cdd:cd00637  85 SILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLSK----- 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 191 disinsIYGLFVLVSTFGMDLFFIFLSYVLILRSV--------------MATASREERLKALNTCVSHILAVLAFYVPMI 256
Cdd:cd00637 160 ------AYTIFLFVLLFLLPLLVIIVCYVRIFRKLrrhrrrirssssnsSRRRRRRRERKVTKTLLIVVVVFLLCWLPYF 233

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 52317265 257 GVSTVHRFGKHVPCYIHVL--MSNVYLFVPPVLNPLIYSAK 295
Cdd:cd00637 234 ILLLLDVFGPDPSPLPRILyfLALLLAYLNSAINPIIYAFF 274

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

26-303

1.64e-11

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 63.35 E-value: 1.64e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  26 WLSGPLCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIH 105
Cdd:cd14967   1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 106 FFSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPlPFLIKRlPICRSNVLSHSYCLHPdmm 185
Cdd:cd14967  81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLP-PLVGWR-DETQPSVVDCECEFTP--- 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 186 rlacadisiNSIYGLFVLVSTFGMDLFFIFLSYVLILRsvmaTASREerLKALNTcvshILAVLAFYV----PMIGVSTV 261
Cdd:cd14967 156 ---------NKIYVLVSSVISFFIPLLIMIVLYARIFR----VARRE--LKAAKT----LAIIVGAFLlcwlPFFIIYLV 216

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 52317265 262 HRFgkHVPCYIHVLMSNVYLFVPPV---LNPLIYSAKTKEIRRAI 303
Cdd:cd14967 217 SAF--CPPDCVPPILYAVFFWLGYLnsaLNPIIYALFNRDFRRAF 259

7tmA_Adenosine_R_A2B

cd15069

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...

33-168

2.33e-09

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320197 [Multi-domain] Cd Length: 294 Bit Score: 57.25 E-value: 2.33e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLP---TVLRTFCLNARNITFDACLIqmflihfFSM 109
Cdd:cd15069   9 IIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPfaiTISLGFCTDFHSCLFLACFV-------LVL 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 52317265 110 MESGI--LLAMSFDRYVAICDPLRYATVLTteviaamglGAAARSFI-TLFPLPFLIKRLPI 168
Cdd:cd15069  82 TQSSIfsLLAVAVDRYLAIKVPLRYKSLVT---------GKRARGVIaVLWVLAFGIGLTPF 134

7tmA_FMRFamide_R-like

cd14978

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...

24-231

2.51e-07

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.

Pssm-ID: 410630 [Multi-domain] Cd Length: 299 Bit Score: 51.09 E-value: 2.51e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  24 HSWLSGPLCVmyaVALGGNTVILqAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLR-----TFCLNARNITFDACL 98
Cdd:cd14978   3 YGYVLPVICI---FGIIGNILNL-VVLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLpyiadYSSSFLSYFYAYFLP 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  99 IQMFLIHFFSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSY 178
Cdd:cd14978  79 YIYPLANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYY 158

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 52317265 179 CLHPDMMRLACADISINSIygLFVLVSTFGMDLFFIFLSYVLILRSVMATASR 231
Cdd:cd14978 159 VIPTLLRQNETYLLKYYFW--LYAIFVVLLPFILLLILNILLIRALRKSKKRR 209

7tmA_5-HT1A_vertebrates

cd15330

serotonin receptor subtype 1A from vertebrates, member of the class A family of ...

31-302

4.14e-07

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320453 [Multi-domain] Cd Length: 260 Bit Score: 50.36 E-value: 4.14e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  31 LCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMM 110
Cdd:cd15330   7 LGTLILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTS 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 111 ESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPlPFLIKRLPICRSNvlshsyclhPDmmrlACA 190
Cdd:cd15330  87 SILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIP-PMLGWRTPEDRSD---------PD----ACT 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 191 dISINSIYGLFvlvSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCV-SHILAVLAFYVpmigVSTVHRFGKHvP 269
Cdd:cd15330 153 -ISKDPGYTIY---STFGAFYIPLILMLVLYGRIFKAAARERKTVKTLGIIMgTFILCWLPFFI----VALVLPFCES-T 223

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 52317265 270 CYIHVLMSNVYLFV---PPVLNPLIYSAKTKEIRRA 302
Cdd:cd15330 224 CHMPELLGAIINWLgysNSLLNPIIYAYFNKDFQSA 259

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

25-303

3.94e-06

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 47.59 E-value: 3.94e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  25 SWLSGPLCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLI 104
Cdd:cd14969   1 YVLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 105 HFFSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMglgaaarSFITLFPLPFLIkrLPICRSNvlshSYCLHPDM 184
Cdd:cd14969  81 TFLGLVSISTLAALAFERYLVIVRPLKAFRLSKRRALILI-------AFIWLYGLFWAL--PPLFGWS----SYVPEGGG 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 185 MRlaCA----DISINSI-YGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSH-----------ILAV 248
Cdd:cd14969 148 TS--CSvdwySKDPNSLsYIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNSAITKRTkkaekkvakmvLVMI 225

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 52317265 249 LAFYV---PMIGVSTVHRFGKHVPcyIHVLMSNV-YLF--VPPVLNPLIYSAKTKEIRRAI 303
Cdd:cd14969 226 VAFLIawtPYAVVSLYVSFGGEST--IPPLLATIpALFakSSTIYNPIIYVFMNKQFRRAL 284

7tmA_5-HT1_5_7

cd15064

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...

31-302

5.29e-06

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320192 [Multi-domain] Cd Length: 258 Bit Score: 46.94 E-value: 5.29e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  31 LCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACliQMFLIHFFSMM 110
Cdd:cd15064   7 LSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLC--DIWISLDVTCC 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 111 ESGI--LLAMSFDRYVAICDPLRYATVLTTEVIAAM-GLGAAARSFITLFPLPFLikrlpicrsnvlshsycLHPDMMRL 187
Cdd:cd15064  85 TASIlhLCVIALDRYWAITDAVEYAHKRTPKRAAVMiALVWTLSICISLPPLFGW-----------------RTPDSEDP 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 188 ACADISINSIYGLFvlvSTFGMdlFFIFLSYVLILRSVMATASREERlKALNTCVSHILAVLAFYVPMIGVSTVHRFGKH 267
Cdd:cd15064 148 SECLISQDIGYTIF---STFGA--FYIPLLLMLILYWKIYRAAARER-KAAKTLGIILGAFIVCWLPFFLVALIVPLCSH 221

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 52317265 268 vpCYIHVLMSNVYLF---VPPVLNPLIYSAKTKEIRRA 302
Cdd:cd15064 222 --CWIPLALKSFFLWlgyFNSLINPLIYTFFNKDFRKA 257

7tmA_Adenosine_R_A3

cd15070

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...

32-300

5.98e-06

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.

Pssm-ID: 320198 [Multi-domain] Cd Length: 280 Bit Score: 47.08 E-value: 5.98e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  32 CVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPtvLRTFCLNARNITFDACLIQMFLIHFFSMME 111
Cdd:cd15070   8 ILIGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIP--LAIVVSLGVTIHFYSCLFMSCLLVVFTHAS 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 112 SGILLAMSFDRYVAICDPLRYATVLTTEVI-AAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSyCLHPDMMRLaca 190
Cdd:cd15070  86 IMSLLAIAVDRYLRVKLTVRYRIVTTQRRIwLALGLCWLVSFLVGLTPMFGWNRKPSLESVNTTPLQ-CQFTSVMRM--- 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 191 DISINSIYGLFVLVSTFGMDLFFIFLSYVLILR-SVMATASREERL---KALNTCVSHILAVLAF---YVPMIGVSTVHR 263
Cdd:cd15070 162 DYMVYFSFFTWILIPLVIMCALYVDIFYIIRNKlSQNATGFRETGAfygREFKTAKSLALVLFLFavcWLPLSIINCVVY 241

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 52317265 264 FGKHVP---CYIHVLMSNvylfVPPVLNPLIYSAKTKEIR 300
Cdd:cd15070 242 FNPKVPkiaLYLGILLSH----ANSMMNPIVYACKIKKFK 277

7tmA_NTSR-like

cd14979

neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...

37-302

6.18e-06

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320110 [Multi-domain] Cd Length: 300 Bit Score: 46.96 E-value: 6.18e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  37 VALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFcLNARNITFD--ACLIQMFLIHFFSMMESGI 114
Cdd:cd14979  13 VGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNF-WWQYPWAFGdgGCKLYYFLFEACTYATVLT 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 115 LLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPIcrsNVLSHSycLHPDMMRlaCADISI 194
Cdd:cd14979  92 IVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFLMGIQYL---NGPLPG--PVPDSAV--CTLVVD 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 195 NSIYGLFVLVST---FGMDLFFIFLSYVLILR--SVMATASREERLKALNTCVS-------------------------- 243
Cdd:cd14979 165 RSTFKYVFQVSTfifFVLPMFVISILYFRIGVklRSMRNIKKGTRAQGTRNVELslsqqarrqvvkmlgavviaffvcwl 244

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 52317265 244 --HILAVLAFYVPMIGVsTVHRFgkhvpcYIHVLM-SNVYLFVPPVLNPLIYSAKTKEIRRA 302
Cdd:cd14979 245 pfHAQRLMFSYASKEDT-FLFDF------YQYLYPiSGILFYLSSAINPILYNLMSSRFRVA 299

7tmA_EDG-like

cd14972

endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...

32-302

1.17e-05

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 46.13 E-value: 1.17e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  32 CVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLihFFSMME 111
Cdd:cd14972   6 IVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSL--VLSLLA 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 112 S-GILLAMSFDRYVAICDPLRYATVLTteviaamgLGAAARSFITLFPLPFLIKRLPICRSNVLShsyCLHPdmmrlACA 190
Cdd:cd14972  84 SaYSLLAIAVDRYISIVHGLTYVNNVT--------NKRVKVLIALVWVWSVLLALLPVLGWNCVL---CDQE-----SCS 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 191 DIS--INSIYGLFVLVSTFgMDLFFIFLSYVLILRSV----MATASREERLKALNTCVSHILAV---------LAFYVPM 255
Cdd:cd14972 148 PLGpgLPKSYLVLILVFFF-IALVIIVFLYVRIFWCLwrhaNAIAARQEAAVPAQPSTSRKLAKtvvivlgvfLVCWLPL 226

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 52317265 256 IGVSTVHRFGKHVPCYIHVLmsnVYLFVPPVLN----PLIYSAKTKEIRRA 302
Cdd:cd14972 227 LILLVLDVLCPSVCDIQAVF---YYFLVLALLNsainPIIYAFRLKEMRRA 274

7tmA_purinoceptor-like

cd14982

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...

96-303

1.49e-05

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341318 [Multi-domain] Cd Length: 283 Bit Score: 45.72 E-value: 1.49e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  96 ACLIqMFLIHFFSMMESGILLA-MSFDRYVAICDPLRYATVLTTEViaAMGLGAAARSFITLFPLPFLIKRLPICRSNvl 174
Cdd:cd14982  72 LCRL-TGLLFYINMYGSILFLTcISVDRYLAVVHPLKSRRLRRKRY--AVGVCAGVWILVLVASVPLLLLRSTIAKEN-- 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 175 SHSYCLHPDMMRLAcadisINSIYGLFVLVSTFGMDLFFIFLSYVLILRSV----MATASREERLKALNTCVSHILAVLA 250
Cdd:cd14982 147 NSTTCFEFLSEWLA-----SAAPIVLIALVVGFLIPLLIILVCYSLIIRALrrrsKQSQKSVRKRKALRMILIVLAVFLV 221

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 52317265 251 FYVP-----MIGVSTVHRFGKHVPCYIHVLMSNVYLF----VPPVLNPLIYSAKTKEIRRAI 303
Cdd:cd14982 222 CFLPyhvtrILYLLVRLSFIADCSARNSLYKAYRITLclasLNSCLDPLIYYFLSKTFRKRL 283

7tmA_5-HT2A

cd15304

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...

25-302

1.90e-05

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341345 [Multi-domain] Cd Length: 267 Bit Score: 45.31 E-value: 1.90e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  25 SWLSGPLCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNAR-NITFDACLIQMFL 103
Cdd:cd15304   1 NWPALLTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRwPLPSKLCAVWIYL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 104 IHFFSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRlpiCRSNVLSHSYCLHPD 183
Cdd:cd15304  81 DVLFSTASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQ---DDSKVFKEGSCLLAD 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 184 MMrlacadisinsiyglFVLVSTFG---MDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLafYVPMIGVST 260
Cdd:cd15304 158 EN---------------FVLIGSFVaffIPLTIMVITYFLTIKSLQQSISNEQKASKVLGIVFFLFVVM--WCPFFITNV 220

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 52317265 261 VHRFGKHVpCYIHVL--MSNVYLFV---PPVLNPLIYSAKTKEIRRA 302
Cdd:cd15304 221 MAVICKES-CNEVVIggLLNVFVWIgylSSAVNPLVYTLFNKTYRSA 266

7tmA_TACR

cd15390

neurokinin receptors (or tachykinin receptors), member of the class A family of ...

33-221

2.52e-05

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320512 [Multi-domain] Cd Length: 289 Bit Score: 44.98 E-value: 2.52e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVaiSMATLPTVLR-TFCLNArNITFDA--CLIQMF------L 103
Cdd:cd15390   9 VMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADL--LISAFNTVFNfTYLLYN-DWPFGLfyCKFSNFvaittvA 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 104 IHFFSMMesgillAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAArsfiTLFPLPFLI----KRLPICRSNVLSHSYC 179
Cdd:cd15390  86 ASVFTLM------AISIDRYIAIVHPLRPRLSRRTTKIAIAVIWLAS----FLLALPQLLysttETYYYYTGSERTVCFI 155

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 52317265 180 LHPDMMRLacadiSINSIYGLFVLVSTFGMDLFFIFLSYVLI 221
Cdd:cd15390 156 AWPDGPNS-----LQDFVYNIVLFVVTYFLPLIIMAVAYTRV 192

7tmA_5-HT2C

cd15305

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...

25-133

2.78e-05

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341346 [Multi-domain] Cd Length: 275 Bit Score: 44.90 E-value: 2.78e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  25 SWLSGPLCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLN-ARNITFDACLIQMFL 103
Cdd:cd15305   1 NWPALLILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDyAWPLPRYLCPIWISL 80

                        90       100       110
                ....*....|....*....|....*....|
gi 52317265 104 IHFFSMMESGILLAMSFDRYVAICDPLRYA 133
Cdd:cd15305  81 DVLFSTASIMHLCAISLDRYVAIRNPIEHS 110

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

31-163

2.86e-05

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 44.92 E-value: 2.86e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  31 LCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAIS-MATLPTVLRTFCLNARNITFDACLIQMFLIhfFSM 109
Cdd:cd15196   7 LATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVAlFNVLPQLIWDITYRFYGGDLLCRLVKYLQV--VGM 84

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 52317265 110 MESG-ILLAMSFDRYVAICDPLRYATvLTTEVIAAMGLGAAARSFitLFPLPFLI 163
Cdd:cd15196  85 YASSyVLVATAIDRYIAICHPLSSHR-WTSRRVHLMVAIAWVLSL--LLSIPQLF 136

7tmA_OT_R

cd15387

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...

31-131

4.10e-05

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320509 [Multi-domain] Cd Length: 297 Bit Score: 44.42 E-value: 4.10e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  31 LCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISM-ATLPTVLrtfclnaRNITFD------ACLIQMFL 103
Cdd:cd15387   7 LALILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVfQVLPQLI-------WDITFRfygpdfLCRLVKYL 79

                        90       100
                ....*....|....*....|....*...
gi 52317265 104 IHFFSMMESGILLAMSFDRYVAICDPLR 131
Cdd:cd15387  80 QVVGMFASTYMLLLMSIDRCLAICQPLR 107

7tmA_GnRHR-like

cd15195

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...

31-303

4.49e-05

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.

Pssm-ID: 320323 [Multi-domain] Cd Length: 293 Bit Score: 44.31 E-value: 4.49e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  31 LCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLP------TVLRTFCLNArnitfdACLIQMFLI 104
Cdd:cd15195   7 TWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPmdavwnYTVEWLAGDL------MCRVMMFLK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 105 HFFSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIaaMGLGAAARSFITLFPLPFLIkrlpicrsNVLSHSYclhPDM 184
Cdd:cd15195  81 QFGMYLSSFMLVVIALDRVFAILSPLSANQARKRVKI--MLTVAWVLSALCSIPQSFIF--------SVLRKMP---EQP 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 185 MRLACADISINS------IYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALN---------------TCVS 243
Cdd:cd15195 148 GFHQCVDFGSAPtkkqerLYYFFTMILSFVIPLIITVTCYLLILFEISKMAKRARDTPISNrrrsrtnslerarmrTLRM 227

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 52317265 244 HILAVLAFYV---PMIGVSTVHRFGKHV-----PCYIHVLMSNVYLfvPPVLNPLIYSAKTKEIRRAI 303
Cdd:cd15195 228 TALIVLTFIVcwgPYYVLGLWYWFDKESiknlpPALSHIMFLLGYL--NPCLHPIIYGVFMKEIRNWI 293

7tmA_tyramine_octopamine_R-like

cd15060

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...

31-159

4.51e-05

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320188 [Multi-domain] Cd Length: 260 Bit Score: 43.96 E-value: 4.51e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  31 LCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNarNITFDACLIQMFLIHFFSMM 110
Cdd:cd15060   7 LSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLG--KWLFGIHLCQMWLTCDILCC 84

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 52317265 111 ESGIL--LAMSFDRYVAICDPLRYATVLTTE-VIAAMGLGAAARSFITLFPL 159
Cdd:cd15060  85 TASILnlCAIALDRYWAIHDPINYAQKRTLKrVLLMIVVVWALSALISVPPL 136

7tmA_5-HT2B

cd15306

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...

39-131

5.31e-05

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341347 [Multi-domain] Cd Length: 277 Bit Score: 44.05 E-value: 5.31e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  39 LGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNAR-NITFDACLIQMFLIHFFSMMESGILLA 117
Cdd:cd15306  15 IGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAMwPLPLVLCPIWLFLDVLFSTASIMHLCA 94

                        90
                ....*....|....
gi 52317265 118 MSFDRYVAICDPLR 131
Cdd:cd15306  95 ISLDRYIAIKKPIQ 108

7tmA_CCKR-like

cd14993

cholecystokinin receptors and related proteins, member of the class A family of ...

31-226

6.22e-05

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.

Pssm-ID: 320124 [Multi-domain] Cd Length: 296 Bit Score: 43.74 E-value: 6.22e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  31 LCVMYAV----ALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPtvlrtfcLNARNITFDACLIQMFLIHF 106
Cdd:cd14993   3 LIVLYVVvfllALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMP-------LTLLENVYRPWVFGEVLCKA 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 107 FSMME-----SGI--LLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSN--VLSHS 177
Cdd:cd14993  76 VPYLQgvsvsASVltLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVYELEEIISSEpgTITIY 155

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 52317265 178 YCLH---PDMMRLacadisinsIYGLFVLVSTFGMDLFFIFLSYVLILRSVM 226
Cdd:cd14993 156 ICTEdwpSPELRK---------AYNVALFVVLYVLPLLIISVAYSLIGRRLW 198

7tmA_Melanopsin-like

cd15083

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...

33-303

8.08e-05

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320211 [Multi-domain] Cd Length: 291 Bit Score: 43.48 E-value: 8.08e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLP-TVLRTFclnARNITFD--ACLIQMFLIHFFSM 109
Cdd:cd15083   9 IIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPlMVISSF---SGRWIFGktGCDMYGFSGGLFGI 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 110 MESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPlPF-------LIKRLPICRSNVLSHSyclhp 182
Cdd:cd15083  86 MSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLP-PLfgwsryvLEGLLTSCSFDYLSRD----- 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 183 dmmrlacadiSINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMAT----------------ASREERLKA-LNTCVSHI 245
Cdd:cd15083 160 ----------DANRSYVICLLIFGFVLPLLIIIYCYSFIFRAVRRHekamkemakrfskselSSPKARRQAeVKTAKIAL 229

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 52317265 246 LAVLAFYV---PMIGVSTVHRFGKHVPCYIHVLMSNVYLF-VPPVLNPLIYSAKTKEIRRAI 303
Cdd:cd15083 230 LLVLLFCLawtPYAVVALIGQFGYLEVLTPLATAIPAAFAkTSAIYNPVIYAFSHPKFRRAL 291

7tmA_5-HT6

cd15054

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...

25-158

9.90e-05

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320182 [Multi-domain] Cd Length: 267 Bit Score: 43.25 E-value: 9.90e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  25 SWLSGPLCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIqmfLI 104
Cdd:cd15054   1 GWVAAFLCLIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPI---WY 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 52317265 105 HFFSMMESGILL---AMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFP 158
Cdd:cd15054  78 AFDVMCCSASILnlcVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFL 134

7tmA_Octopamine_R

cd15063

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...

31-302

1.25e-04

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.

Pssm-ID: 320191 [Multi-domain] Cd Length: 266 Bit Score: 42.87 E-value: 1.25e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  31 LCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPtvlrtfcLNARNITFDACLI-----QMFLIH 105
Cdd:cd15063   7 LTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLP-------FSAVNEVLDVWIFghtwcQIWLAV 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 106 FFSMMESGI--LLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYClhpd 183
Cdd:cd15063  80 DVWMCTASIlnLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLVGWNDGKDGIMDYSGSSSL---- 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 184 mmRLACaDISINSIYGLFVLVSTFGMDLFFIFLSYVLILRsvmaTASREerLKALNTCVSHILAVLAFYVPMIGVSTVHR 263
Cdd:cd15063 156 --PCTC-ELTNGRGYVIYSALGSFYIPMLVMLFFYFRIYR----AARME--TKAAKTVAIIVGCFIFCWLPFFTVYLVRA 226

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 52317265 264 FGKHvpCYIHVLMSNVYL--FVPPVLNPLIYSAKTKEIRRA 302
Cdd:cd15063 227 FCED--CIPPLLFSVFFWlgYCNSALNPCIYALFSRDFRFA 265

7tmA_Adenosine_R_A2A

cd15068

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...

37-137

1.72e-04

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320196 [Multi-domain] Cd Length: 293 Bit Score: 42.62 E-value: 1.72e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  37 VALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLP---TVLRTFCLNARNITFDACLIqmflihfFSMMESG 113
Cdd:cd15068  13 LAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPfaiTISTGFCAACHGCLFIACFV-------LVLTQSS 85

                        90       100
                ....*....|....*....|....*.
gi 52317265 114 I--LLAMSFDRYVAICDPLRYATVLT 137
Cdd:cd15068  86 IfsLLAIAIDRYIAIRIPLRYNGLVT 111

7tmA_MC5R

cd15354

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...

37-137

2.14e-04

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320476 [Multi-domain] Cd Length: 270 Bit Score: 42.23 E-value: 2.14e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  37 VALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMESGI-- 114
Cdd:cd15354  13 ISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHLVIEDAFVRHIDNVFDSLICISVva 92

                        90       100
                ....*....|....*....|....*..
gi 52317265 115 ----LLAMSFDRYVAICDPLRYATVLT 137
Cdd:cd15354  93 smcsLLAIAVDRYVTIFYALRYHNIMT 119

7tmA_Vasopressin-like

cd14986

vasopressin receptors and its related G protein-coupled receptors, member of the class A ...

31-131

2.18e-04

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.

Pssm-ID: 320117 [Multi-domain] Cd Length: 295 Bit Score: 42.36 E-value: 2.18e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  31 LCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTvlrtfclnarNITFDA----------CLIQ 100
Cdd:cd14986   7 LGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLT----------QIIWEAtgewvagdvlCRIV 76

                        90       100       110
                ....*....|....*....|....*....|.
gi 52317265 101 MFLIHFFSMMESGILLAMSFDRYVAICDPLR 131
Cdd:cd14986  77 KYLQVVGLFASTYILVSMSLDRYQAIVKPMS 107

7tmA_MC1R

cd15351

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...

37-157

2.21e-04

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320473 [Multi-domain] Cd Length: 271 Bit Score: 42.09 E-value: 2.21e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  37 VALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMESGILL 116
Cdd:cd15351  13 VSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQHMDNVIDTMICSSVVS 92

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 52317265 117 AMSF------DRYVAICDPLRYATVLTTE--VIAAMGLGAAARSFITLF 157
Cdd:cd15351  93 SLSFlgaiavDRYITIFYALRYHSIMTLQraVNAIAGIWLASTVSSTLF 141

7tmA_V1aR

cd15385

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...

31-131

2.51e-04

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320507 [Multi-domain] Cd Length: 301 Bit Score: 42.12 E-value: 2.51e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  31 LCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATlptVLRTFCLNarnITFD------ACLIQMFLi 104
Cdd:cd15385   7 LAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFFQ---VLPQLCWD---ITYRfygpdfLCRIVKHL- 79

                        90       100
                ....*....|....*....|....*...
gi 52317265 105 HFFSMMESG-ILLAMSFDRYVAICDPLR 131
Cdd:cd15385  80 QVLGMFASTyMLVMMTADRYIAICHPLK 107

7tmA_SREB3_GPR173

cd15217

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...

31-203

3.03e-04

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320345 [Multi-domain] Cd Length: 329 Bit Score: 41.86 E-value: 3.03e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  31 LCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFcLNARNITFDA--CLIQMFLIHFFS 108
Cdd:cd15217   7 LGLIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSI-RNGSAWTYSVlsCKIVAFMAVLFC 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 109 MMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSN---VLSHSYCLHPD-- 183
Cdd:cd15217  86 FHAAFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMAFPPVFDVGTYKFIREEdqcIFEHRYFKANDtl 165

                       170       180
                ....*....|....*....|..
gi 52317265 184 --MMRLACADISINSIYGLFVL 203
Cdd:cd15217 166 gfMLMLAVLIVATHIVYGKLLL 187

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

97-144

4.84e-04

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 41.00 E-value: 4.84e-04

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 52317265  97 CLIQMFLIHFFSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAM 144
Cdd:cd15055  73 CKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKIC 120

7tmA_GPR151

cd15002

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...

66-301

5.14e-04

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320133 [Multi-domain] Cd Length: 280 Bit Score: 40.86 E-value: 5.14e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  66 LSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMESGILLAMSFDRYVAICDPLRYATVL---TTEVIA 142
Cdd:cd15002  43 LSAADLLLLLFSVPFRAAAYSKGSWPLGWFVCKTADWFGHACMAAKSFTIAVLAKACYMYVVNPTKQVTIKqrrITAVVA 122

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 143 AMGLGAAarsfitLFPLPFLIKRLPICRSNVLSHSYCL----HPDMmrlacadisinSIYGLFVLVSTFGMDLFFIFLSY 218
Cdd:cd15002 123 SIWVPAC------LLPLPQWLFRTVKQSEGVYLCILCIpplaHEFM-----------SAFVKLYPLFVFCLPLTFALFYF 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 219 VLILRSV--MATASREERLKALNTCVSHILA--VLAF-------YVPMIGVSTVHRFGKHVPCYIHVlMSNVYLFVPPVL 287
Cdd:cd15002 186 WRAYGQCqrRGTKTQNLRNQIRSRKLTHMLLsvVLAFtilwlpeWVAWLWLIHIKSSGSSPPQLFNV-LAQLLAFSISSV 264

                       250
                ....*....|....
gi 52317265 288 NPLIYSAKTKEIRR 301
Cdd:cd15002 265 NPIIFLLMSEEFRE 278

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

41-143

6.09e-04

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 40.70 E-value: 6.09e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  41 GNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLP---TVLRTFCLNARNITFDACLIQMF-LIHFFSmmesgiLL 116
Cdd:cd14968  17 GNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPlaiLISLGLPTNFHGCLFMACLVLVLtQSSIFS------LL 90

                        90       100
                ....*....|....*....|....*..
gi 52317265 117 AMSFDRYVAICDPLRYATVLTTEVIAA 143
Cdd:cd14968  91 AIAIDRYLAIKIPLRYKSLVTGRRAWG 117

7tmA_Histamine_H1R

cd15050

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...

31-159

6.09e-04

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320178 [Multi-domain] Cd Length: 263 Bit Score: 40.87 E-value: 6.09e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  31 LCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMM 110
Cdd:cd15050   7 LSTISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTA 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 52317265 111 ESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPL 159
Cdd:cd15050  87 SIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVIPI 135

7tmA_NPSR

cd15197

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...

31-163

6.60e-04

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).

Pssm-ID: 320325 [Multi-domain] Cd Length: 294 Bit Score: 40.87 E-value: 6.60e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  31 LCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPT--VLR-TFCLNARNItfdACLIQMFLIHFF 107
Cdd:cd15197   7 LWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVLTdiIWRiTVEWRAGDF---ACKVIRYLQVVV 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 52317265 108 SMMESGILLAMSFDRYVAICDPLRYAtvlTTEVIAAMgLGAAARSFITLFPLPFLI 163
Cdd:cd15197  84 TYASTYVLVALSIDRYDAICHPMNFS---QSGRQARV-LICVAWILSALFSIPMLI 135

7tmA_MC3R

cd15352

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...

37-137

6.98e-04

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320474 [Multi-domain] Cd Length: 272 Bit Score: 40.64 E-value: 6.98e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  37 VALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMESGI-- 114
Cdd:cd15352  13 VSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLETIMIAVLNSGYLVISDQFIQHMDNVFDSMICISLva 92

                        90       100
                ....*....|....*....|....*..
gi 52317265 115 ----LLAMSFDRYVAICDPLRYATVLT 137
Cdd:cd15352  93 sicnLLAIAVDRYVTIFYALRYHSIMT 119

7tmA_P2Y1-like

cd15168

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...

33-253

7.28e-04

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).

Pssm-ID: 341329 [Multi-domain] Cd Length: 284 Bit Score: 40.38 E-value: 7.28e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISmATLPTVLRTFCLNARNITFD-ACLIQMFLIHFFSMME 111
Cdd:cd15168   9 VVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYL-LSLPFLIYYYANGDHWIFGDfMCKLVRFLFYFNLYGS 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 112 SGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIkRLPICRSNVLSHSYCLHpdmmrlacAD 191
Cdd:cd15168  88 ILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILFFA-TTGRKNNRTTCYDTTSP--------EE 158

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 52317265 192 ISINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMAT----ASREERLKALNTCvshILAVLAFYV 253
Cdd:cd15168 159 LNDYVIYSMVLTGLGFLLPLLIILACYGLIVRALIRKlgegVTSALRRKSIRLV---IIVLALFAV 221

7tmA_SREB-like

cd15005

super conserved receptor expressed in brain and related proteins, member of the class A family ...

31-158

7.35e-04

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320134 [Multi-domain] Cd Length: 329 Bit Score: 40.52 E-value: 7.35e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  31 LCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTfCLNARNITFDA--CLIQMFLIHFFS 108
Cdd:cd15005   7 LGLILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMAS-VRHGSGWIYGAlsCKVIAFLAVLFC 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 52317265 109 MMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFP 158
Cdd:cd15005  86 FHSAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFP 135

7tmA_MCR

cd15103

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

37-137

8.69e-04

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320231 [Multi-domain] Cd Length: 270 Bit Score: 40.17 E-value: 8.69e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  37 VALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMESGI-- 114
Cdd:cd15103  13 VSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQHIDNVIDSMICSSLla 92

                        90       100
                ....*....|....*....|....*..
gi 52317265 115 ----LLAMSFDRYVAICDPLRYATVLT 137
Cdd:cd15103  93 sicsLLAIAVDRYITIFYALRYHSIMT 119

7tmA_5-HT1F

cd15334

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...

42-302

8.99e-04

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320456 [Multi-domain] Cd Length: 259 Bit Score: 40.32 E-value: 8.99e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  42 NTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMESGILLAMSFD 121
Cdd:cd15334  18 NSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSVDITCCTCSILHLSAIALD 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 122 RYVAICDPLRYATVLTTEVIAAMGLGAAARS-FITLFPLPFLIKRLPICRSNVLSHSYClhpdmmrlacadisinsiygL 200
Cdd:cd15334  98 RYRAITDAVEYARKRTPKHAGIMIAVVWIISiFISMPPLFWRHQTTSREDECIIKHDHI--------------------V 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 201 FVLVSTFGMdlFFIFLSYVLILRSVMATASREERLKALNTCV---SHILAVLAFYVPMIGVSTVHRfgkhvpCYIHVLMS 277
Cdd:cd15334 158 FTIYSTFGA--FYIPLALILILYYKIYRAATRERKAATTLGLilgAFVICWLPFFVKEVIVNTCDS------CYISEEMS 229

                       250       260
                ....*....|....*....|....*...
gi 52317265 278 NVYL---FVPPVLNPLIYSAKTKEIRRA 302
Cdd:cd15334 230 NFLTwlgYINSLINPLIYTIFNEDFKKA 257

7tmA_Ap5-HTB1-like

cd15065

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...

31-168

1.01e-03

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.

Pssm-ID: 320193 [Multi-domain] Cd Length: 300 Bit Score: 40.03 E-value: 1.01e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  31 LCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMM 110
Cdd:cd15065   6 LSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCSTA 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 52317265 111 ESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMglgaaarsFITLFPLPFLIKRLPI 168
Cdd:cd15065  86 SILNLCAISLDRYIHIKKPLKYERWMTTRRALVV--------IASVWILSALISFLPI 135

7tmA_GHSR-like

cd15928

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...

33-303

1.04e-03

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.

Pssm-ID: 320594 [Multi-domain] Cd Length: 288 Bit Score: 40.17 E-value: 1.04e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15928   9 VLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLVLPLDLYRLWRYRPWRFGDLLCRLMYFFSETCTYASI 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIkrlpicrsNVLSHSYCLHPDMMRlaCADI 192
Cdd:cd15928  89 LHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVLV--------GVEHIQGQQTPRGFE--CTVV 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 193 SINS-IYGLFVLVST--FGMDLFFIFLSYVLILR--------SVMATASREER-----LKALNTCV-SHILAVLAFYVPM 255
Cdd:cd15928 159 NVSSgLLSVMLWVSTsfFFVPMVCLSLLYGLIGRalwdrrqrSRTAGASRRDNnhrqtVRMLAVIVlAFVLCWLPFHVGR 238

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 52317265 256 IGVSTVHRFGKHVpCYIH---VLMSNVYLFVPPVLNPLIYSAKTKEIRRAI 303
Cdd:cd15928 239 VIFNHSRASTKHL-HYVSqyfNLVSFVLFYLSAAINPILYNLMSKRYRYAV 288

7tmA_Trissin_R

cd15012

trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...

32-303

1.17e-03

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320140 [Multi-domain] Cd Length: 277 Bit Score: 39.73 E-value: 1.17e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  32 CVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMatlptvlrtFCL--NARNITFDA-------CLIQMF 102
Cdd:cd15012   7 TLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGI---------FCVlqNLSIYLIPSwpfgevlCRMYQF 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 103 LIHFFSMMESGILLAMSFDRYVAICDPLRYATVLTTEV----IAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSy 178
Cdd:cd15012  78 VHSLSYTASIGILVVISVERYIAILHPLRCKQLLTAARlrvtIVTVWLTSAVYNTPYFVFSQTVEILVTQDGQEEEICV- 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 179 clhpdmmrLACADISInSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVP---- 254
Cdd:cd15012 157 --------LDREMFNS-KLYDTINFIVWYLIPLLIMTVLYSKISIVLWKSSSIEARRKVVRLLVAVVVSFALCNLPyhar 227

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 52317265 255 -MIGVSTVHRFGKHVPCYIHVLMSNVYLFVPPVLNPLIYSAKTKEIRRAI 303
Cdd:cd15012 228 kMWQYWSEPYRCDSNWNALLTPLTFLVLYFNSAVNPLLYAFLSKRFRQSM 277

7tmA_SREB1_GPR27

cd15216

super conserved receptor expressed in brain 1 (or GPR27), member of the class A family of ...

31-158

1.56e-03

super conserved receptor expressed in brain 1 (or GPR27), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320344 [Multi-domain] Cd Length: 332 Bit Score: 39.62 E-value: 1.56e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  31 LCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLrtfcLNARNITFDA--------CLIQMF 102
Cdd:cd15216   7 LSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVM----LAARRAAAAAgtppgalgCKLLAF 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 52317265 103 LIHFFSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAA-ARSFITLFP 158
Cdd:cd15216  83 LAALFCFHAAFLLLGVGVTRYLAIAHHRFYAERLAGWPCAAMLVCAAwALALAAAFP 139

7tmA_Prostanoid_R

cd14981

G protein-coupled receptors for prostanoids, member of the class A family of ...

33-137

1.69e-03

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.

Pssm-ID: 320112 [Multi-domain] Cd Length: 288 Bit Score: 39.54 E-value: 1.69e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHE--PMYYFLSMLSFSDVAISMATLPTVLRTFclnARNITFD----ACLIQMFLIHF 106
Cdd:cd14981   9 LMFVFGVLGNLLALIVLARSSKSHKwsVFYRLVAGLAITDLLGILLTSPVVLAVY---ASNFEWDggqpLCDYFGFMMSF 85

                        90       100       110
                ....*....|....*....|....*....|.
gi 52317265 107 FSMMESGILLAMSFDRYVAICDPLRYATVLT 137
Cdd:cd14981  86 FGLSSLLIVCAMAVERFLAITHPFFYNSHVK 116

7tmA_mAChR_GAR-2-like

cd15302

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...

37-302

1.83e-03

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320429 [Multi-domain] Cd Length: 266 Bit Score: 39.34 E-value: 1.83e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  37 VALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPtVLRTFCLNARNITFDACLIQMFLIHFFSMMESGIL- 115
Cdd:cd15302  13 ITVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLESMP-FYTVYVLNGDYWPLGWVLCDLWLSVDYTVCLVSIYt 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 116 -LAMSFDRYVAICDPLRYATVLTTE----VIAAMGLGAAARSFITLFPLPFLIKrlpicRSNVLSHSYCLHPDMmrlaca 190
Cdd:cd15302  92 vLLITIDRYCSVKIPAKYRNWRTPRkvllIIAITWIIPALLFFISIFGWQYFTG-----QGRSLPEGECYVQFM------ 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 191 disINSIYGLFVLVSTFGMDLFFIFLSYVLILRsvmaTASREerLKALNTCVSHILAVLAFYVPMIGVSTVHRFGKHVPC 270
Cdd:cd15302 161 ---TDPYFNMGMYIGYYWTTLIVMLILYAGIYR----AANRA--RKALRTITFILGAFVICWTPYHILATIYGFCEAPPC 231

                       250       260       270
                ....*....|....*....|....*....|....
gi 52317265 271 YIHVLMSNVYL--FVPPVLNPLIYSAKTKEIRRA 302
Cdd:cd15302 232 VNETLYTISYYlcYMNSPINPFCYALANQQFKKT 265

7tmA_5-HT2_insect-like

cd15307

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...

39-307

2.00e-03

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320433 [Multi-domain] Cd Length: 279 Bit Score: 39.16 E-value: 2.00e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  39 LGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMESGILLAM 118
Cdd:cd15307  15 AAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCTASIMHLCTI 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 119 SFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPicrSNVLSHSYCLHPDmmrlacadisinSIY 198
Cdd:cd15307  95 SVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKDH---ASVLVNGTCQIPD------------PVY 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 199 GLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAF-----YVPMIGVSTVHRFGKHVPCYIH 273
Cdd:cd15307 160 KLVGSIVCFYIPLGVMLLTYCLTVRLLARQRSRHGRIIRLEQKATKVLGVVFFtfvilWSPFFVLNLLPTVCAECEERIS 239

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 52317265 274 VLMSNVYL---FVPPVLNPLIYSAKTKEIRRAIFRMF 307
Cdd:cd15307 240 HWVFDVVTwlgYASSMVNPIFYTIFNKVFRQAFKKVL 276

7tmA_5-HT2

cd15052

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...

31-302

2.13e-03

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320180 [Multi-domain] Cd Length: 262 Bit Score: 38.83 E-value: 2.13e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  31 LCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLP-TVLRTFCLNARNITFDACLIQMFLIHFFSM 109
Cdd:cd15052   7 LLLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPlSILTELFGGVWPLPLVLCLLWVTLDVLFCT 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 110 MESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPicrSNVLSHSYCLHPDmmrlac 189
Cdd:cd15052  87 ASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSPIPVLGIIDT---TNVLNNGTCVLFN------ 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 190 adisinsiyGLFVLVSTFGMdlFFIFLSYVLILRSVMATASREERlKAlntcvSHILAVLAF-----YVPMIGVSTVHRF 264
Cdd:cd15052 158 ---------PNFVIYGSIVA--FFIPLLIMVVTYALTIRLLSNEQ-KA-----SKVLGIVFAvfvicWCPFFITNILTGL 220

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 52317265 265 GKHVPCYIHVLMSNVYL---FVPPVLNPLIYSAKTKEIRRA 302
Cdd:cd15052 221 CEECNCRISPWLLSVFVwlgYVSSTINPIIYTIFNKTFRRA 261

7tmA_TAAR5

cd15318

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...

41-140

2.31e-03

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320441 [Multi-domain] Cd Length: 282 Bit Score: 39.07 E-value: 2.31e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  41 GNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMESGILLAMSF 120
Cdd:cd15318  17 GNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFHLCFISI 96

                        90       100
                ....*....|....*....|
gi 52317265 121 DRYVAICDPLRYATVLTTEV 140
Cdd:cd15318  97 DRHCAICDPLLYPSKFTIRV 116

7tmA_GPR45

cd15403

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...

34-126

2.54e-03

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320525 [Multi-domain] Cd Length: 301 Bit Score: 39.06 E-value: 2.54e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  34 MYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMESG 113
Cdd:cd15403  10 MIAIGFLGNAIVCLIVYQKPAMRSAINLLLATLAFSDIMLSLLCMPFTAVTIITVDWHFGAHFCRISAMLYWFFVLEGVA 89

                        90
                ....*....|...
gi 52317265 114 ILLAMSFDRYVAI 126
Cdd:cd15403  90 ILLIISVDRFLII 102

7tmA_mAChR_M2

cd15297

muscarinic acetylcholine receptor subtype M2, member of the class A family of ...

37-158

2.71e-03

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320424 [Multi-domain] Cd Length: 262 Bit Score: 38.79 E-value: 2.71e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  37 VALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAI-----SMATLPTVLRTFCLNArnITFDACLIQMFLIHFFSMME 111
Cdd:cd15297  13 VTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIgvfsmNLYTLYTVIGYWPLGP--VVCDLWLALDYVVSNASVMN 90

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 52317265 112 sgiLLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFP 158
Cdd:cd15297  91 ---LLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAP 134

7tmA_mAChR

cd15049

muscarinic acetylcholine receptor subfamily, member of the class A family of ...

37-159

2.83e-03

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341322 [Multi-domain] Cd Length: 262 Bit Score: 38.45 E-value: 2.83e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  37 VALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAI---SMA--TLPTVLRTFCLNArnitfDACLIQMFLIHFFSMME 111
Cdd:cd15049  13 VTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIglvSMNlyTVYLVMGYWPLGP-----LLCDLWLALDYVASNAS 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 52317265 112 SGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPL 159
Cdd:cd15049  88 VMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFVLWAPA 135

7tmA_V1bR

cd15386

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...

29-131

3.04e-03

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320508 [Multi-domain] Cd Length: 302 Bit Score: 38.63 E-value: 3.04e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  29 GPLCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISM-ATLPTVLrtFCLNARNITFDACLIQMFLIHFF 107
Cdd:cd15386   5 GVLAAILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALfQVLPQLI--WEITYRFQGPDLLCRAVKYLQVL 82

                        90       100
                ....*....|....*....|....*
gi 52317265 108 SMMESG-ILLAMSFDRYVAICDPLR 131
Cdd:cd15386  83 SMFASTyMLIMMTVDRYIAVCHPLR 107

7tmA_Opsin5_neuropsin

cd15074

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...

37-240

3.11e-03

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.

Pssm-ID: 320202 [Multi-domain] Cd Length: 284 Bit Score: 38.80 E-value: 3.11e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  37 VALGGN-TVILQAVRvEPSLHEPMYYFLSMLSFSDVAISMATLPTVLrTFCLNARNITFDA-CLIQMFLIHFFSMMESGI 114
Cdd:cd15074  13 LSTLGNgTVLFVLYR-RRSKLKPAELLTVNLAVSDLGISVFGYPLAI-ISAFAHRWLFGDIgCVFYGFCGFLFGCCSINT 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 115 LLAMSFDRYVAICDPlRYATVLTTE----VIAAMGLGAAarsFITLFPLpflikrlpicrsnVLSHSYclHPDMMRLAC- 189
Cdd:cd15074  91 LTAISIYRYLKICHP-PYGPKLSRRhvciVIVAIWLYAL---FWAVAPL-------------VGWGSY--GPEPFGTSCs 151

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 52317265 190 -----ADISINS---IYGLFVLVstFGMDLFFIFLSYVLILRSVMATASREERLKALNT 240
Cdd:cd15074 152 idwtgASASVGGmsyIISIFIFC--YLLPVLIIVFSYVKIIRKVKSSRKRVAGFDSRSK 208

7tmA_mAChR_DM1-like

cd15301

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...

37-144

3.30e-03

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320428 [Multi-domain] Cd Length: 270 Bit Score: 38.65 E-value: 3.30e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  37 VALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMESGILL 116
Cdd:cd15301  13 VTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDYLASNASVLNLL 92

                        90       100
                ....*....|....*....|....*...
gi 52317265 117 AMSFDRYVAICDPLRYATVLTTEVIAAM 144
Cdd:cd15301  93 IISFDRYFSVTRPLTYRARRTTKKAAVM 120

7TM_GPCR_Srsx

pfam10320

Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis ...

41-144

3.60e-03

Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.

Pssm-ID: 255903 [Multi-domain] Cd Length: 257 Bit Score: 38.34 E-value: 3.60e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265    41 GNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNarNITFDACLIQMFLIHFFSMMESGILLAMSF 120
Cdd:pfam10320   7 GNVLMIHLTFRKKKLRSKCSILICVQCIAHLICLCGEIVFVVLLFTGT--QLTRNECFWMISFYIFGQTAQGPLMLMIGI 84

                          90       100
                  ....*....|....*....|....
gi 52317265   121 DRYVAICDPLRYATVLTTEVIAAM 144
Cdd:pfam10320  85 DRLIAVKFPIFYRLLSSSKYLFIQ 108

7tmA_GHSR

cd15131

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...

32-163

3.92e-03

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.

Pssm-ID: 320259 [Multi-domain] Cd Length: 291 Bit Score: 38.33 E-value: 3.92e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  32 CV-MYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFclNARNITFDACLIQMFLIHFFSMM 110
Cdd:cd15131   7 CVlLFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMPLDLYRLW--QYRPWNFGDLLCKLFQFVSESCT 84

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 52317265 111 ESGIL--LAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLI 163
Cdd:cd15131  85 YSTILniTALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLSAGPIFVLV 139

7tmA_Peropsin

cd15073

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...

41-303

4.21e-03

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.

Pssm-ID: 320201 [Multi-domain] Cd Length: 280 Bit Score: 38.18 E-value: 4.21e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  41 GNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMESGILLAMSF 120
Cdd:cd15073  17 SNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMASIGLLTVVAV 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 121 DRYVAICDPLRYATvLTTEVIAAMGLGAAARSFI-TLFPLpflikrlpicrsnVLSHSYCLHPD----MMRLACADISIN 195
Cdd:cd15073  97 DRYLTICRPDLGRK-MTTNTYTVMILLAWTNAFFwAAMPL-------------VGWASYALDPTgatcTINWRKNDSSFV 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 196 SiYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASrEERLKALN-----------TCVSHILAVLAFYVPMIGVSTVHRF 264
Cdd:cd15073 163 S-YTMSVIVVNFIVPLAVMFYCYYNVSRFVKKVLA-SDCLESVNidwtdqndvtkMSVIMIVMFLVAWSPYSIVCLWASF 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 52317265 265 G--KHVPCYIHVlmsnvylfVPPVL-------NPLIYSAKTKEIRRAI 303
Cdd:cd15073 241 GepKKIPPWMAI--------IPPLFaksstfyNPCIYVIANKKFRRAI 280

7tmA_MC2R_ACTH_R

cd15350

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...

36-137

4.75e-03

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320472 [Multi-domain] Cd Length: 270 Bit Score: 37.84 E-value: 4.75e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  36 AVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMA-TLPTVLRTFC----LNAR---NITFDACLIQMFLIHFF 107
Cdd:cd15350  12 AVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYkTLENILIILAdmgyLNRRgpfETKLDDIMDSLFCLSLL 91

                        90       100       110
                ....*....|....*....|....*....|
gi 52317265 108 SMMESgiLLAMSFDRYVAICDPLRYATVLT 137
Cdd:cd15350  92 GSIFS--ILAIAADRYITIFHALRYHNIMT 119

7tmA_PSP24-like

cd15213

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...

33-302

4.85e-03

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320341 [Multi-domain] Cd Length: 262 Bit Score: 38.12 E-value: 4.85e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd15213   9 LMIFVGFLGNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVCMPFAAVTIITGRWIFGDIFCRISAMLYWFFVLEGV 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 113 GILLAMSFDRYVAIcdpLRYATVLTTEVIAAMGLGAAARSFITLFPLPF------LIKRLPICrsnVLSHSyclhpdmmr 186
Cdd:cd15213  89 AILLIISVDRYLII---VQRQDKLNPHRAKILIAVSWVLSFCVSFPPLVgwgkyeFPPRAPQC---VLGYT--------- 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 187 lacaDISINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVmatasREERLKALNTcvshILAVLAFYVPMIGVSTVHRFGK 266
Cdd:cd15213 154 ----ESPADRIYVVLLLVAVFFIPFLIMLYSYFCILNTV-----RSFKTRAFTT----ILILFIGFSVCWLPYTVYSLLS 220

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 52317265 267 HVPCYIHV--LMSNVYL---FVPPVLNPLIYSAKTKEIRRA 302
Cdd:cd15213 221 VFSRYSSSfyVISTCLLwlsYLKSAFNPVIYCWRIKKFREA 261

7tmA_VA_opsin

cd15082

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...

33-130

5.21e-03

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320210 [Multi-domain] Cd Length: 291 Bit Score: 37.85 E-value: 5.21e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGN-TVILQAVRVEpSLHEPMYYFLSMLSFSDVAISMaTLPTVlrTFCLNARNITF---DACLIQMFLIHFFS 108
Cdd:cd15082  22 VVTSLSLAENfAVMLVTFRFK-QLRQPLNYIIVNLSVADFLVSL-TGGTI--SFLTNARGYFFlgvWACVLEGFAVTFFG 97

                        90       100
                ....*....|....*....|..
gi 52317265 109 MMESGILLAMSFDRYVAICDPL 130
Cdd:cd15082  98 IVALWSLAVLAFERFFVICRPL 119

7tmA_TAAR5-like

cd15317

trace amine-associated receptor 5 and similar receptors, member of the class A family of ...

37-140

5.54e-03

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320440 [Multi-domain] Cd Length: 290 Bit Score: 37.81 E-value: 5.54e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  37 VALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLP-TVLRT----------FCLNARNITFDACLIQMFLIH 105
Cdd:cd15317  13 ITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPfSMIRTvetcwyfgdlFCKFHTGLDLLLCTTSIFHLC 92

                        90       100       110
                ....*....|....*....|....*....|....*
gi 52317265 106 FfsmmesgillaMSFDRYVAICDPLRYATVLTTEV 140
Cdd:cd15317  93 F-----------IAIDRYYAVCDPLRYPSKITVQV 116

7tmA_TAAR2_3_4

cd15312

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...

115-142

6.93e-03

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320437 [Multi-domain] Cd Length: 289 Bit Score: 37.72 E-value: 6.93e-03

                        10        20
                ....*....|....*....|....*...
gi 52317265 115 LLAMSFDRYVAICDPLRYATVLTTEVIA 142
Cdd:cd15312  91 LCFIAVDRYYAVCDPLHYRTKITTPVIK 118

7tmA_mAChR_M1

cd17790

muscarinic acetylcholine receptor subtype M1, member of the class A family of ...

33-158

7.23e-03

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341356 [Multi-domain] Cd Length: 262 Bit Score: 37.25 E-value: 7.23e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  33 VMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMES 112
Cdd:cd17790   9 ILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDYVASNASV 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 52317265 113 GILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFP 158
Cdd:cd17790  89 MNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVLWAP 134

7tmA_GPR185-like

cd15960

G protein-coupled receptor 185 and similar proteins, member of the class A family of ...

31-303

8.24e-03

G protein-coupled receptor 185 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR185, also called GPRx, is a member of the constitutively active GPR3/6/12 subfamily of G protein-coupled receptors. It plays a role in the maintenance of meiotic arrest in Xenopus laevis oocytes through G(s) protein, which leads to increased cAMP levels. In Xenopus laevis, GPR185 is primarily expressed in brain, ovary, and testis; however, its ortholog has not been identified in other vertebrate genomes. GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest.

Pssm-ID: 320626 [Multi-domain] Cd Length: 268 Bit Score: 37.18 E-value: 8.24e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  31 LCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFdaCLIQMFLIHFFSMM 110
Cdd:cd15960   7 LCVTGTVMACENAIVIAILFYTPSLRAPMFILIGSLALADLLAGLGLIANFVAIYVMNSEAVTL--CSAGLLLAAFSASV 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 111 ESgiLLAMSFDRYVAICDPLRYATVLTTEVIAAMglgaaarsFITLFPLPFLIKRLPICRSNvlshsyCLHPDMMRLACA 190
Cdd:cd15960  85 CS--LLAITVDRYLSLYNALTYHTERTLTFTYGL--------LALLWLTCIGIGLLPAMGWN------CLRAPASCSVLR 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265 191 DISINSIYGL---FVLVSTFGMDLF-------FIFLSYVLILRSVMATASREERLKALNTcVSHILAVLAF-YVPMIGVS 259
Cdd:cd15960 149 PVTKNNAAVLavsFLLLFALMMQLYlqicriaFRHAQQIAVQHQFVNFCLASSTRKGVST-LSLILATFAFcWVPFAVYS 227

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 52317265 260 TVHRfgkhvPCYIHVLmsNVYLFVP----PVLNPLIYSAKTKEIRRAI 303
Cdd:cd15960 228 MVAD-----SSYPMIY--TYYLVLPaacnSVINPIIYAFRNPDIQKSL 268

7tmA_mAChR_M3

cd15299

muscarinic acetylcholine receptor subtype M3, member of the class A family of ...

37-158

9.10e-03

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320426 [Multi-domain] Cd Length: 274 Bit Score: 37.23 E-value: 9.10e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  37 VALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMESGILL 116
Cdd:cd15299  16 VTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLL 95

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 52317265 117 AMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFP 158
Cdd:cd15299  96 VISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAP 137

7tmA_D2-like_dopamine_R

cd15053

D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...

31-133

9.87e-03

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320181 [Multi-domain] Cd Length: 263 Bit Score: 36.94 E-value: 9.87e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317265  31 LCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFclnarnITFDACLIQMFLIHFFSMM 110
Cdd:cd15053   7 LLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVE------VNGGKWYLGPILCDIYIAM 80

                        90       100       110
                ....*....|....*....|....*....|
gi 52317265 111 E-----SGI--LLAMSFDRYVAICDPLRYA 133
Cdd:cd15053  81 DvmcstASIfnLCAISIDRYIAVTQPIKYA 110

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01