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Conserved domains on  [gi|2029299615|ref|NP_001002880|]
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protein chibby homolog 1 [Homo sapiens]

Protein Classification

Cby_like domain-containing protein( domain architecture ID 10630374)

Cby_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Chibby pfam14645
Chibby family; This family includes the eukaryotic chibby proteins. These proteins inhibit the ...
 2-115 1.43e-50

Chibby family; This family includes the eukaryotic chibby proteins. These proteins inhibit the wingless/Wnt pathway by binding to beta-catenin and inhibiting beta-catenin-mediated transcriptional activation. Chibby is Japanese for small, and is named after the RNAi phenotype seen in Drosophila.


:

Pssm-ID: 464233  Cd Length: 113  Bit Score: 155.93  E-value: 1.43e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029299615   2 PFFGNTFSPKKTPPRKSASLSNLHSLDRSTREVELGLEYGSPTMNLAGQSLKFENGQWIAETGVSGGvDRREVQRLRRRN 81
Cdd:pfam14645   1 PLFSNKFSPKKIPLRKSSSLSNLYLLDPSTREAELGLDYGPIKLRLGGQELVFEDGQWVSESGGAGG-TGKEMQRLKKRN 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2029299615  82 QQLEEENNLLRLKVDILLDMLSESTAESHLMEKE 115
Cdd:pfam14645  80 QQLEEENNLLKLKIELLLDMLTETTAELHLLEKE 113
 
Name Accession Description Interval E-value
Chibby pfam14645
Chibby family; This family includes the eukaryotic chibby proteins. These proteins inhibit the ...
 2-115 1.43e-50

Chibby family; This family includes the eukaryotic chibby proteins. These proteins inhibit the wingless/Wnt pathway by binding to beta-catenin and inhibiting beta-catenin-mediated transcriptional activation. Chibby is Japanese for small, and is named after the RNAi phenotype seen in Drosophila.


Pssm-ID: 464233  Cd Length: 113  Bit Score: 155.93  E-value: 1.43e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029299615   2 PFFGNTFSPKKTPPRKSASLSNLHSLDRSTREVELGLEYGSPTMNLAGQSLKFENGQWIAETGVSGGvDRREVQRLRRRN 81
Cdd:pfam14645   1 PLFSNKFSPKKIPLRKSSSLSNLYLLDPSTREAELGLDYGPIKLRLGGQELVFEDGQWVSESGGAGG-TGKEMQRLKKRN 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2029299615  82 QQLEEENNLLRLKVDILLDMLSESTAESHLMEKE 115
Cdd:pfam14645  80 QQLEEENNLLKLKIELLLDMLTETTAELHLLEKE 113
Cby_like cd07429
Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins; ...
 1-108 1.50e-49

Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins; Chibby(Cby) is a well-conserved nuclear protein that functions as part of the Wnt/beta-catenin signaling pathway. Specifically, Cby binds directly to beta-catenin by interacting with its central region, which harbors armadillo repeats. Cby-beta-catenin interactions may also involve 14-3-3 proteins. By competing with other binding partners of beta-catenin, the Tcf/Lef transcription factors, Cby inhibits transcriptional activation. Cby has been shown to play a role in adipocyte differentiation. The C-terminal region of Cby appears to contain an alpha-helical coiled-coil motif.


Pssm-ID: 143631  Cd Length: 108  Bit Score: 153.26  E-value: 1.50e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029299615   1 MPFFGNTFSPKKTPPRKSASLSNLHSLDRSTREVELGLEYGSPTMNLAGQSLKFENGQWIAETGVSGGVDRREVQRLRRR 80
Cdd:cd07429     1 MPLFGRKFSPKKTPPRKSASLSNLRLLDRSTRQAELGLDYGPIRLKLGGQELVFEDGRWISESGGSSGVSGREVLRLKKK 80

                          90       100
                  ....*....|....*....|....*...
gi 2029299615  81 NQQLEEENNLLRLKVDILLDMLSESTAE 108
Cdd:cd07429    81 NQQLEEENNLLKLKIEVLLDMLAETTAE 108
 
Name Accession Description Interval E-value
Chibby pfam14645
Chibby family; This family includes the eukaryotic chibby proteins. These proteins inhibit the ...
 2-115 1.43e-50

Chibby family; This family includes the eukaryotic chibby proteins. These proteins inhibit the wingless/Wnt pathway by binding to beta-catenin and inhibiting beta-catenin-mediated transcriptional activation. Chibby is Japanese for small, and is named after the RNAi phenotype seen in Drosophila.


Pssm-ID: 464233  Cd Length: 113  Bit Score: 155.93  E-value: 1.43e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029299615   2 PFFGNTFSPKKTPPRKSASLSNLHSLDRSTREVELGLEYGSPTMNLAGQSLKFENGQWIAETGVSGGvDRREVQRLRRRN 81
Cdd:pfam14645   1 PLFSNKFSPKKIPLRKSSSLSNLYLLDPSTREAELGLDYGPIKLRLGGQELVFEDGQWVSESGGAGG-TGKEMQRLKKRN 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2029299615  82 QQLEEENNLLRLKVDILLDMLSESTAESHLMEKE 115
Cdd:pfam14645  80 QQLEEENNLLKLKIELLLDMLTETTAELHLLEKE 113
Cby_like cd07429
Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins; ...
 1-108 1.50e-49

Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins; Chibby(Cby) is a well-conserved nuclear protein that functions as part of the Wnt/beta-catenin signaling pathway. Specifically, Cby binds directly to beta-catenin by interacting with its central region, which harbors armadillo repeats. Cby-beta-catenin interactions may also involve 14-3-3 proteins. By competing with other binding partners of beta-catenin, the Tcf/Lef transcription factors, Cby inhibits transcriptional activation. Cby has been shown to play a role in adipocyte differentiation. The C-terminal region of Cby appears to contain an alpha-helical coiled-coil motif.


Pssm-ID: 143631  Cd Length: 108  Bit Score: 153.26  E-value: 1.50e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029299615   1 MPFFGNTFSPKKTPPRKSASLSNLHSLDRSTREVELGLEYGSPTMNLAGQSLKFENGQWIAETGVSGGVDRREVQRLRRR 80
Cdd:cd07429     1 MPLFGRKFSPKKTPPRKSASLSNLRLLDRSTRQAELGLDYGPIRLKLGGQELVFEDGRWISESGGSSGVSGREVLRLKKK 80

                          90       100
                  ....*....|....*....|....*...
gi 2029299615  81 NQQLEEENNLLRLKVDILLDMLSESTAE 108
Cdd:cd07429    81 NQQLEEENNLLKLKIEVLLDMLAETTAE 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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