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Conserved domains on  [gi|50593023|ref|NP_001002756|]
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NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform 3 [Homo sapiens]

Protein Classification

NifU family protein( domain architecture ID 10471400)

NifU family protein proposed to provide a molecular scaffold for the assembly of [Fe-S] clusters

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NifU pfam01106
NifU-like domain; This is an alignment of the carboxy-terminal domain. This is the only common ...
 32-98 2.46e-31

NifU-like domain; This is an alignment of the carboxy-terminal domain. This is the only common region between the NifU protein from nitrogen-fixing bacteria and rhodobacterial species. The biochemical function of NifU is unknown.


:

Pssm-ID: 460066 [Multi-domain]  Cd Length: 67  Bit Score: 105.21  E-value: 2.46e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 50593023    32 IKELLDTRIRPTVQEDGGDVIYKGFEDGIVQLKLQGSCTSCPSSIITLKNGIQNMLQFYIPEVEGVE 98
Cdd:pfam01106   1 IEEVLEEEIRPALQADGGDIELVDVDDGVVYVRLQGACSGCPSSTMTLKNGIEQALKEKVPEVKRVE 67
 
Name Accession Description Interval E-value
NifU pfam01106
NifU-like domain; This is an alignment of the carboxy-terminal domain. This is the only common ...
 32-98 2.46e-31

NifU-like domain; This is an alignment of the carboxy-terminal domain. This is the only common region between the NifU protein from nitrogen-fixing bacteria and rhodobacterial species. The biochemical function of NifU is unknown.


Pssm-ID: 460066 [Multi-domain]  Cd Length: 67  Bit Score: 105.21  E-value: 2.46e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 50593023    32 IKELLDTRIRPTVQEDGGDVIYKGFEDGIVQLKLQGSCTSCPSSIITLKNGIQNMLQFYIPEVEGVE 98
Cdd:pfam01106   1 IEEVLEEEIRPALQADGGDIELVDVDDGVVYVRLQGACSGCPSSTMTLKNGIEQALKEKVPEVKRVE 67
NifU COG0694
Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain [Posttranslational modification, ...
 19-99 1.07e-29

Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440458 [Multi-domain]  Cd Length: 176  Bit Score: 104.74  E-value: 1.07e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593023  19 EAGSEEDDEVVAMIKELLDTRIRPTVQEDGGDVIYKGFEDGIVQLKLQGSCTSCPSSIITLKNGIQNMLQFYIPEVEGVE 98
Cdd:COG0694  96 SFHALTDAELEERIEEVLDEEIRPALASDGGDIELVDVEDGVVYVRLGGACSGCPSSTMTLKNGIERALKERVPEVKEVE 175


                .
gi 50593023  99 Q 99
Cdd:COG0694 176 A 176
PRK11190 PRK11190
iron-sulfur cluster biogenesis protein NfuA;
35-107 7.92e-03

iron-sulfur cluster biogenesis protein NfuA;


Pssm-ID: 183027 [Multi-domain]  Cd Length: 192  Bit Score: 34.22  E-value: 7.92e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 50593023   35 LLDTRIRPTVQEDGGDV-IYKGFEDGIVQLKLQGSCTSCPSSIITLKNGIQ-NMLQFYIPEVEGVEQVMDDESDE 107
Cdd:PRK11190 114 VLQSQINPQLAGHGGRVsLMEITEDGYAILQFGGGCNGCSMVDVTLKEGIEkQLLNEFPGELKGVRDLTEHQRGE 188
 
Name Accession Description Interval E-value
NifU pfam01106
NifU-like domain; This is an alignment of the carboxy-terminal domain. This is the only common ...
 32-98 2.46e-31

NifU-like domain; This is an alignment of the carboxy-terminal domain. This is the only common region between the NifU protein from nitrogen-fixing bacteria and rhodobacterial species. The biochemical function of NifU is unknown.


Pssm-ID: 460066 [Multi-domain]  Cd Length: 67  Bit Score: 105.21  E-value: 2.46e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 50593023    32 IKELLDTRIRPTVQEDGGDVIYKGFEDGIVQLKLQGSCTSCPSSIITLKNGIQNMLQFYIPEVEGVE 98
Cdd:pfam01106   1 IEEVLEEEIRPALQADGGDIELVDVDDGVVYVRLQGACSGCPSSTMTLKNGIEQALKEKVPEVKRVE 67
NifU COG0694
Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain [Posttranslational modification, ...
 19-99 1.07e-29

Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440458 [Multi-domain]  Cd Length: 176  Bit Score: 104.74  E-value: 1.07e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593023  19 EAGSEEDDEVVAMIKELLDTRIRPTVQEDGGDVIYKGFEDGIVQLKLQGSCTSCPSSIITLKNGIQNMLQFYIPEVEGVE 98
Cdd:COG0694  96 SFHALTDAELEERIEEVLDEEIRPALASDGGDIELVDVEDGVVYVRLGGACSGCPSSTMTLKNGIERALKERVPEVKEVE 175


                .
gi 50593023  99 Q 99
Cdd:COG0694 176 A 176
PRK11190 PRK11190
iron-sulfur cluster biogenesis protein NfuA;
35-107 7.92e-03

iron-sulfur cluster biogenesis protein NfuA;


Pssm-ID: 183027 [Multi-domain]  Cd Length: 192  Bit Score: 34.22  E-value: 7.92e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 50593023   35 LLDTRIRPTVQEDGGDV-IYKGFEDGIVQLKLQGSCTSCPSSIITLKNGIQ-NMLQFYIPEVEGVEQVMDDESDE 107
Cdd:PRK11190 114 VLQSQINPQLAGHGGRVsLMEITEDGYAILQFGGGCNGCSMVDVTLKEGIEkQLLNEFPGELKGVRDLTEHQRGE 188
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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