BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50539726    14 VTLNVGGHLYTTSISTLQRYPDSMLGAMFRGDFPTTRDAQGNYFIDRDGTLFRYILNFLRTS-ELTLPVDfTELDLLRKE 92
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFPDTRLGRLLELECDDYDDDTNEYFFDRSPKHFETILNFYRTGgKLHRPEE-VCLDEFLEE 79

                          90
                  ....*....|
gi 50539726    93 ADFYQIEPLI 102
Cdd:pfam02214  80 AEFYGLDELA 89

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD6, KCTD21 and similar proteins; KCTD6, also called KCASH3 (KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 3), is a substrate-specific adaptor of cullin-3, effectively regulating protein levels of the muscle small ankyrin-1 isoform 5 (sAnk1.5). KCTD21, also called KCASH2, functions as a substrate-specific adaptor of cullin-3, promoting the ubiquitination and degradation of histone deacetylase HDAC1, thereby inhibiting the deacetylation-mediated transcriptional activation of the Hedgehog effectors Gli1 and Gli2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50539726  13 PVTLNVGGHLYTTSISTLQRYPDSMLGAMFRGDFPTTRDAQGNYFIDRDGTLFRYILNFLRTSELTLPVDFTELDLLRKE 92
Cdd:cd18365   2 IVNLNVGGVHYTTTLATLTRFPDSMLGAMFSGSMPTTRDDQGNYFIDRDGTLFRYILNFLRSSQLSLPEDFKEYDLLLRE 81

                        90
                ....*....|...
gi 50539726  93 ADFYQIEPLIQCL 105
Cdd:cd18365  82 ADFYQIEPLIEAL 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 4 (KCTD4); KCTD4 is a BTB/POZ domain-containing protein with an unknown biological function. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50539726  14 VTLNVGGHLYTTSISTLQRYPDSMLGAMFRGDFPTTRDAQGNYFIDRDGTLFRYILNFLRTSELTLPVDFTELDLLRKEA 93
Cdd:cd18364   2 VTLNVGGYLYITQRQTLTKYPDSFLEGMVNGKIQCTVDADGNYFIDRDGLLFRHVLNFLRNGELLLPEGFQENQLLALEA 81

                ....*
gi 50539726  94 DFYQI 98
Cdd:cd18364  82 DFYQL 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins; The potassium channel tetramerization domain (KCTD) family proteins contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. Some others show Cullin-independent functions including binding and regulation of GABA (gamma-aminobutyric acid) receptors (KCTD8, KCTD12 and KCTD16) and inhibition of AP-2 function (KCTD15). KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50539726  14 VTLNVGGHLYTTSISTLQRYPDSMLGAMFRGDFPTTRDAQGNYFIDRDGTLFRYILNFLRTSELTLPVDFTELDLLRKEA 93
Cdd:cd18316   1 VKLNVGGTLFTTSRSTLLKDPDSLLAALFSGRWPLPRDEDGSIFIDRDPELFRHILNFLRTGKLPLPSDFVELEELLAEA 80

                ...
gi 50539726  94 DFY 96
Cdd:cd18316  81 EFY 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD1 and KCTD15; This subfamily of KCTD proteins includes KCTD1 and KCTD15. KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50539726  14 VTLNVGGHLYTTSISTLQRYPDSMLGAMFRGDFPTTRDA-QGNYFIDRDGTLFRYILNFLRTSELTLPVDFTELDLLRKE 92
Cdd:cd18361   1 VHIDVGGHIYTSSLETLTKYPESRLGKLFNGSIPIVLDSlKQHYFIDRDGKMFRHILNFLRTSKLLLPDDFTEFDLLYEE 80

                        90
                ....*....|...
gi 50539726  93 ADFYQIEPLIQCL 105
Cdd:cd18361  81 ARYYELQPMVKQL 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 7 (KCTD7); KCTD7 is a BTB/POZ domain-containing protein that has an impact on K+ fluxes, neurotransmitter synthesis, and neuronal function. It functions as a regulator of potassium conductance in neurons, and is involved in the control of excitability of cortical neurons. Mutations in KCTD7 may cause progressive myoclonus epilepsy (PME). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50539726  14 VTLNVGGHLYTTSISTLQRYPDSMLGAMFRGDFPTTRDAQGNYFIDRDGTLFRYILNFLRTSELTLPvdfTELDLLRKEA 93
Cdd:cd18366   6 VPLNVGGMHFTTRLSTLRKYEDSMLAAMFSGRHHIPKDSEGRYFIDRDGSYFGYILNFLRDGDLPPR---ERARAVYKEA 82

                        90
                ....*....|
gi 50539726  94 DFYQIEPLIQ 103
Cdd:cd18366  83 QYYGIGPLIE 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 15 (KCTD15); KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains, closely related to KCTD15, form pentamers.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50539726  13 PVTLNVGGHLYTTSISTLQRYPDSMLGAMFRGDFPTTRDA-QGNYFIDRDGTLFRYILNFLRTSELTLPVDFTELDLLRK 91
Cdd:cd18388   3 PVHIDVGGHMYTSSLATLTKYPDSRISRLFNGTEPIVLDSlKQHYFIDRDGEIFRYILSFLRTSKLLLPEDFKDFNLLYE 82

                        90
                ....*....|....
gi 50539726  92 EADFYQIEPLIQCL 105
Cdd:cd18388  83 EAKYYQLQPMVKEL 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 1 (KCTD1); KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50539726  13 PVTLNVGGHLYTTSISTLQRYPDSMLGAMFRGDFPTTRDA-QGNYFIDRDGTLFRYILNFLRTSELTLPVDFTELDLLRK 91
Cdd:cd18387   4 PVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSlKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYSLLYE 83

                        90
                ....*....|.
gi 50539726  92 EADFYQIEPLI 102
Cdd:cd18387  84 EAKYFQLQPML 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 12 (KCTD12); KCTD12, also called predominantly fetal expressed T1 domain (Pfetin), is a BTB/POZ domain-containing protein that is an auxiliary subunit of GABAB receptors associated with mood disorders. It regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. It also regulates colorectal cancer cell stemness through the ERK pathway. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50539726  14 VTLNVGGHLYTTSISTLQRYPDSMLGAMFRGDFPT--TRDAQGNYFIDRDGTLFRYILNFLRTSELTLPVDFTELDLLRK 91
Cdd:cd18397   5 VELNVGGQVYVTRHTTLVSVPDSLLWHMFSQQKPGelARDSKGRFFLDRDGFLFRYILDYLRDLQLVLPDYFPERSRLQR 84

                        90
                ....*....|....*
gi 50539726  92 EADFYQIEPLIQCLN 106
Cdd:cd18397  85 EAEFFQLPELVKRLN 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16); KCTD16 is a BTB/POZ domain-containing protein that is an auxiliary subunit of GABAB receptors associated with mood disorders. It interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50539726  14 VTLNVGGHLYTTSISTLQRYPDSMLGAMFRGDFPTT----RDAQGNYFIDRDGTLFRYILNFLRTSELTLPVDFTELDLL 89
Cdd:cd18398   5 VELNVGGQVYFTRHATLVSIPHSLLWKMFSPKRDTAndlaKDSKGRFFIDRDGFLFRYILDYLRDRQVVLPDHFPEKGRL 84

                        90
                ....*....|....*.
gi 50539726  90 RKEADFYQIEPLIQCL 105
Cdd:cd18398  85 KREAEYFQLPDLVKLL 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3) and SH3KBP1-binding protein 1 (SHKBP1); The group of KCTD proteins includes KCTD3 and SHKBP1. KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50539726  14 VTLNVGGHLYTTSISTLQRYPDSMLGAMFRGDFPTTRDAQGNYFIDRDGTLFRYILNFLRTSELTLPVdfTELDLLRKEA 93
Cdd:cd18363   4 INLNVGGKRFSTSRQTLTWIPDSFFTSLLSGRISSLKDETGAIFIDRDPKLFSIILNYLRTKEIDLRN--VDISSLRHEA 81

                ....*
gi 50539726  94 DFYQI 98
Cdd:cd18363  82 EFYGI 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3); KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50539726  14 VTLNVGGHLYTTSISTLQRYPDSMLGAMFRGDFPTTRDAQGNYFIDRDGTLFRYILNFLRTSELTLpvDFTELDLLRKEA 93
Cdd:cd18392   4 IQLNVGGTRFSTSRQTLMWIPDSFFSSLLSGRISSLKDETGAIFIDRDPTAFVPILNFLRTKELDL--RGVNINVLRHEA 81

                ....*..
gi 50539726  94 DFYQIEP 100
Cdd:cd18392  82 EFYGITP 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins; This family includes two protein groups: voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins. Kv channels are membrane proteins with fundamental physiological roles. They are responsible for a variety of electrical phenomena, such as the repolarization of the action potential, spike frequency adaptation, synaptic repolarization, and smooth muscle contraction. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels, and others. All family members contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50539726  14 VTLNVGGHLYTTSISTLQRYPDSMLGAMF-RGDFPTTRDAQGNYFIDRDGTLFRYILNFLRTSELTLPVDFTElDLLRKE 92
Cdd:cd18187   1 VVLNVSGTRFVTNRQTLTRHPDTLLGRMFkPGREFTFPNETGEYFIDRDPTVFRTILNYYRTGKLNCPDGISI-PDLREE 79

                ....
gi 50539726  93 ADFY 96
Cdd:cd18187  80 CDFY 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 13 (KCTD13); KCTD13, also called BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (BACURD1), or TNFAIP1-like protein, is a BTB/POZ domain-containing protein that may function as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of RhoA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD13 BTB domain forms a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50539726  14 VTLNVGGHLYTTSISTLQRyPDSMLGAMFRGDFPTTRDAQGNYFIDRDGTLFRYILNFLRTSELTLPVDFTELDLLRKEA 93
Cdd:cd18400   4 VKLNVGGSLHYTTVQTLTK-QDTMLKAMFSGRVEVLTDSEGWVLIDRSGRHFGTILNYLRDGSVPLPESTRELEELLGEA 82

                        90
                ....*....|...
gi 50539726  94 DFYQIEPLIQ-CL 105
Cdd:cd18400  83 RYYLVQGLVEdCQ 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17); KCTD17 is a BTB/POZ domain-containing protein that functions as a substrate-adaptor for cullin3-RING ubiquitin ligases that polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD17 BTB domains form pentamers.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50539726  14 VTLNVGGHLYTTSISTLQRYPDSMLGAMFRG-DFPTTRDAQGNYFIDRDGTLFRYILNFLRTSELTLPVDFTELDLLrKE 92
Cdd:cd18391   3 VRLNVGGTVFLTTRQTLCREQKSFLSRLCQGeELQSDRDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVL-EE 81

                        90
                ....*....|....*
gi 50539726  93 ADFYQIEPLIQCLND 107
Cdd:cd18391  82 AEFYNIGPLIRIIKD 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, and similar proteins; This subfamily includes potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, all of which function as adaptors of Cullin3 based ubiquitin E3 ubiquitin ligases. KCTD2 suppresses gliomagenesis by destabilizing c-Myc. KCTD5 is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. KCTD17 polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domains form pentamer structures.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50539726  14 VTLNVGGHLYTTSISTLQRYPDSMLGAMFRGD--FPTTRDAQGNYFIDRDGTLFRYILNFLRTSELTLPVDFTELDLLrK 91
Cdd:cd18362   2 VKLNVGGTYFLTTRTTLCRDPKSFLCRLCQEDpdLPSDKDETGAYLIDRDPTYFGPILNYLRHGKLIIDKDLAEEGVL-E 80

                ....*
gi 50539726  92 EADFY 96
Cdd:cd18362  81 EAEFY 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 2 (KCTD2); KCTD2 is a BTB/POZ domain-containing protein that functions as an adaptor of Cullin3 E3 ubiquitin ligase. It suppresses gliomagenesis by destabilizing c-Myc. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domain, highly similar to KCTD2, form pentamer structures.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50539726  14 VTLNVGGHLYTTSISTLQRYPDSMLGAMFRGD--FPTTRDAQGNYFIDRDGTLFRYILNFLRTSELTLPVDFTELDLLrK 91
Cdd:cd18389   3 VRLNVGGTYFVSTKQTLCRDPKSFLYRLCQEDpdLDSDKDETGAYLIDRDPTYFGPILNYLRHGKLIINKELAEEGVL-E 81

                        90
                ....*....|....*.
gi 50539726  92 EADFYQIEPLIQCLND 107
Cdd:cd18389  82 EAEFYNIASLVRLVKE 97

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50539726     14 VTLNVGGHLYTTSISTLQRYPDSMLgAMFRGDFPTTrDAQGNYFIDRDGTLFRYILNFLRTSELTLPVDftELDLLRKEA 93
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFK-ALFSSDFKES-DKSEIYLDDVSPEDFRALLNFLYTGKLDLPEE--NVEELLELA 77

                           90
                   ....*....|.
gi 50539726     94 DFYQIEPLIQC 104
Cdd:smart00225  78 DYLQIPGLVEL 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 5 (KCTD5); KCTD5 is a BTB/POZ domain-containing protein that functions as a substrate adaptor for cullin3 based ubiquitin E3 ligases. It is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 forms pentamers mediated by its BTB domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50539726  14 VTLNVGGHLYTTSISTLQRYPDSMLGAMFRG--DFPTTRDAQGNYFIDRDGTLFRYILNFLRTSELTLPVDFTELDLLrK 91
Cdd:cd18390   7 VRLNVGGTYFLTTRQTLCRDPKSFLYRLCQAdpDLDSDKDETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVL-E 85

                        90
                ....*....|....*.
gi 50539726  92 EADFYQIEPLIQCLND 107
Cdd:cd18390  86 EAEFYNITSLIKLVKD 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3); KCND3, also called voltage-gated potassium channel subunit Kv4.3, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. Mutations in KCND3 cause spinocerebellar ataxia. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND3 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50539726   4 GDWGHRLTHPVTLNVGGHLYTTSISTLQRYPDSMLGAMFRGDFptTRDAQGNYFIDRDGTLFRYILNFLRTSELTLPvDF 83
Cdd:cd18419  27 ADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFF--FNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYP-RY 103

                        90
                ....*....|....*....
gi 50539726  84 TELDLLRKEADFYQIEPLI 102
Cdd:cd18419 104 ECISAYDEELAFYGILPEI 122

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 19 (KCTD19); KCTD19 is a BTB/POZ domain-containing protein with unclear biological function. It may be a host factor involved in Nef-induced downregulation of MHC-I. Nef is a HIV-1-encoded protein that plays a key role in the development of AIDS. KCTD19 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50539726  14 VTLNVGGHLYTTSISTLQRYPDsMLGAMFRGDFPTTRDAqgnYFIDRDGTLFRYILNFLRTSELTLPVDFTELDLLRKEA 93
Cdd:cd18374   3 VKVYVGSHWYATYLKTLLKYPE-LLSNSKKVRWITYGQT---LLISGDGQMFRHILNFLRLGKLLLPSEFKEWPLLCQEV 78

                        90
                ....*....|....
gi 50539726  94 DFYQIEPLIQCLND 107
Cdd:cd18374  79 EEYQIPALSEALRQ 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNC/Kv3 subfamily of Shaw-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains four alpha subunit members, Kv3.1 (KCNC1), Kv3.2 (KCNC2), Kv3.3 (KCNC3), and Kv3.4 (KCNC4), which are orthologs of the Shaw gene in Drosophila. Unlike other Kv subfamilies, Kv3 channels typically open only at positive potentials and both, activation and deactivation, in response to changes in voltage are very rapid. They are uniquely associated with the ability of certain neurons to fire action potentials and to release neurotransmitter at high rates of up to 1,000 Hz. Kv3/KCNC subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50539726  14 VTLNVGGHLYTTSISTLQRYPDSMLGAMFRGDFPTTR-DAQGN-YFIDRDGTLFRYILNFLRTSELTLPVDFTELdLLRK 91
Cdd:cd18379   1 IVINVGGVRHETYKSTLRNLPDTRLAWLTETEASAFDyDPVTGeFFFDRHPGVFAQILNYYRTGKLHCPADVCGP-LFEE 79

                        90
                ....*....|....
gi 50539726  92 EADFY-----QIEP 100
Cdd:cd18379  80 ELAFWgidetQIEP 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 1 (KCNV1); KCNV1, also called neuronal potassium channel alpha subunit HNKA or voltage-gated potassium channel subunit Kv8.1, is a new neuronal voltage-gated potassium channel alpha subunit with specific inhibitory properties towards Shab and Shaw channels. It modulates KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2) channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. It can also down-regulate the channel activity of KCNB1, KCNB2, KCNC4 (also known as Kv3.4) and KCND1 (also known as Kv4.1), possibly by trapping them in intracellular membranes. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50539726  15 TLNVGGHLYTTSISTLQRYPDSMLGAMFRGDFPTTRD-------AQGNYFIDRDGTLFRYILNFLRTSELTLPVDFTELD 87
Cdd:cd18424   2 TINVGGSRFVLSQQVLSSHPETRLGKLAVSVRDSVLElcddanfVDNEYFFDRSSQAFKYIMNYYKTGHLHVMEELCAIS 81

                        90
                ....*....|....
gi 50539726  88 LLrKEADFYQIEPL 101
Cdd:cd18424  82 FL-QEIEYWGIDEL 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNG/Kv6 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv6, also known as subfamily G, includes KCNG1 (Kv6.1), KCNG2 (Kv6.2 or KCNF2), KCNG3 (Kv6.3) and KCNG4 (Kv6.4), which are regulatory alpha subunits and do not form functional channels on their own. KCNG1 can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit, can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. KCNG3, also called voltage-gated potassium channel subunit Kv10.1, is an electrically silent modulatory subunit that can form functional heterotetrameric channels with KCNB1, and further promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1. KCNG4 is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50539726  14 VTLNVGGHLYTTSISTLQRYPDSMLGAMfRG------------DFPTTRDaqgNYFIDRDGTLFRYILNFLRTSELTLPV 81
Cdd:cd18382   1 VIINVGGARYSLPWSTLDRFPLTRLSRL-KAcrseddilrvcdDYDVERN---EFFFDRSPEAFGVILLFLRAGKLRLLR 76

                        90
                ....*....|....*...
gi 50539726  82 DFTELDlLRKEADFYQIE 99
Cdd:cd18382  77 EMCALS-FQEELAYWGIE 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A members 2 (KCNA2) and 3 (KCNA3); KCNA2 is also called NGK1, voltage-gated K(+) channel HuKIV, voltage-gated potassium channel HBK5, or voltage-gated potassium channel subunit Kv1.2. KCNA3 is also called HGK5, HLK3, HPCN3, voltage-gated K(+) channel HuKIII, or voltage-gated potassium channel subunit Kv1.3. KCNA2 and KCNA3 mediate transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA2 primarily functions in the brain and the central nervous system, but also in the cardiovascular system. It prevents aberrant action potential firing and regulates neuronal output. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA2 and KCNA3 are alpha subunits that form functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50539726  14 VTLNVGGHLYTTSISTLQRYPDSMLGAmfrgdfPTTR-----DAQGNYFIDRDGTLFRYILNFLRT-SELTLPVDFTeLD 87
Cdd:cd18403   3 VVINISGLRFETQLKTLAQFPETLLGD------PKKRmryfdPLRNEYFFDRNRPSFDAILYYYQSgGRLRRPVNVP-LD 75

                        90
                ....*....|.
gi 50539726  88 LLRKEADFYQI 98
Cdd:cd18403  76 IFSEEIRFYEL 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shaker and similar proteins; Shaker, also termed protein minisleep, represents a family of putative potassium channel proteins in the nervous system of Drosophila. It is a voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Shaker plays a role in the regulation of sleep need or efficiency. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shaker is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50539726  14 VTLNVGGHLYTTSISTLQRYPDSMLGAMFRGD--FPTTRDaqgNYFIDRDGTLFRYILNFLRT-SELTLPVDfTELDLLR 90
Cdd:cd18410   3 VVINVSGLRFETQLKTLNQFPDTLLGDPQRRNryYDPLRN---EYFFDRNRPSFDAILYYYQSgGRLRRPVN-VPLDVFS 78

                ....*...
gi 50539726  91 KEADFYQI 98
Cdd:cd18410  79 EEIKFYEL 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4; KCNC2, also called Shaw-like potassium channel or voltage-gated potassium channel Kv3.2, is a delayed rectifier voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. It contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. KCNC4, also called KSHIIIC or voltage-gated potassium channel subunit Kv3.4, is a novel high-voltage-activating, tetraethylammonium (TEA)-sensitive, type-A potassium channel that mediates the voltage-dependent potassium ion permeability of excitable membranes. It plays a pivotal role in oxidative stress-related neural cell damage as an oxidation-sensitive channel. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC2 and KCNC4 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50539726  14 VTLNVGGHLYTTSISTLQRYP-------------DSMLGAMFRGDFPTTRDAQGN-YFIDRDGTLFRYILNFLRTSELTL 79
Cdd:cd18415   4 IILNVGGTRHETYRSTLKTLPgtrlallassdpqGDCLTQCSQVGGSDGSPGGGNeFFFDRHPGVFAYVLNYYRTGKLHC 83

                ...
gi 50539726  80 PVD 82
Cdd:cd18415  84 PAD 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 4 (KCNA4); KCNA4 is also called HPCN2, or voltage-gated K(+) channel HuKII, voltage-gated potassium channel HBK4, voltage-gated potassium channel HK1, or voltage-gated potassium channel subunit Kv1.4. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA4 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50539726  14 VTLNVGGHLYTTSISTLQRYPDSMLGAmfrgdfPTTRDA-----QGNYFIDRDGTLFRYILNFLRT-SELTLPVDfTELD 87
Cdd:cd18405   3 VVINVSGLRFETQLKTLAQFPETLLGD------PEKRMRyfdplRNEYFFDRNRPSFDAILYYYQSgGRLKRPVN-VPFD 75

                        90
                ....*....|.
gi 50539726  88 LLRKEADFYQI 98
Cdd:cd18405  76 IFSEEVKFYEL 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 2 (KCNV2); KCNV2, also called voltage-gated potassium channel subunit Kv8.2, is a modulatory voltage-gated potassium channel alpha subunit that modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. KCNV2 is essential for visual function and cone survival. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV2 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50539726  16 LNVGGHLYTTSISTLQRYPDSMLGAMF-------RGDFPTTRDAQGN-YFIDRDGTLFRYILNFLRTSEL 77
Cdd:cd18425   3 INVGGTSYQISYRVAASYPKTRIGRLAtytdrsrKLDLCDDYNVQNDeYFFDRDPAVFHHIYNFYRTGVL 72

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 5 (KCNA5); KCNA5, also called HPCN1, voltage-gated potassium channel HK2, or voltage-gated potassium channel subunit Kv1.5, mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA5 may play a role in regulating the secretion of insulin in normal pancreatic islets. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA5 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50539726  14 VTLNVGGHLYTTSISTLQRYPDSMLGAmfrgdfPTTR-----DAQGNYFIDRDGTLFRYILNFLRT-SELTLPVDFTeLD 87
Cdd:cd18406   3 VIINIAGLRFETQLGTLNQFPDTLLGD------PDKRmryfdPLRNEYFFDRNRPSFDGILYFYQSgGKIRRPVNVS-ID 75

                        90
                ....*....|.
gi 50539726  88 LLRKEADFYQI 98
Cdd:cd18406  76 VFADEIRFYQL 86