|
Name |
Accession |
Description |
Interval |
E-value |
| Caprin-1_C |
pfam12287 |
Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is ... |
620-935 |
1.18e-172 |
|
Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is found in eukaryotes. Proteins in this family are typically between 343 and 708 amino acids in length. This family is the C terminal region of caprin-1. Caprin-1 is a protein involved in regulating cellular proliferation. In mutated phenotypes, the G1 phase of the cell cycle is greatly lengthened, impairing normal proliferation. The C terminal region of caprin-1 contains RGG motifs which are characteriztic of RNA binding domains. It is possible that caprin-1 functions through an RNA binding mechanism.
:
Pssm-ID: 463522 [Multi-domain] Cd Length: 320 Bit Score: 509.72 E-value: 1.18e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 620 LQDLMTQIQGTCNFMQESVLDFDKPS-SAIPTSQPPSATP-----GSPVASKEQNLSSQSDFLQEPLQATSSPVTCSSNA 693
Cdd:pfam12287 1 LQDLMAQIQGTYNFMQDSMLDFDKPSdSAIVSAQPPSQSPdlsqmVCPPASPEQRLSQQSDVLQQPEQTQVSPVSPSSNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 694 ClvttdqASSGSETEFMTSET--PEAAIPP---GKQPSSLASPNPPMAKGSE-QGFQSPPASSSSVTINTAPFQAMQTVF 767
Cdd:pfam12287 81 C------ASSGSEYQFHTSEPpqPEAIDPIqssMSLPSELAPPSPPLSPASQpQVFQSKPASSSGINVNAAPFQSMQTVF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 768 NVNAPLPPRKEQEIKE-SPYSPGYNQSFTTASTQTPPQCQLPSIHVEQTVhsqetAANYHPDGTIQVSNGSLAFYPAQTN 846
Cdd:pfam12287 155 NVNAPVPPRNEQELKEsSQYSSGYNQSFSSQSTQTVPQCQLPSEQLEQTV-----VGAYHPDGTIQVSNGHLAFYPAQTN 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 847 VFPRPTQPFVNSRGSVRGCTRGGRLITNSYRSPGGYK-GFDTYRG-LPSISNGNYSQLQFQAREYSGAPYSQRDNFQQCY 924
Cdd:pfam12287 230 GFPRPPQPFYNSRGSPRGGPRGGRGLMNGYRGPNGFKgGFDGYRGpFPNTPNGGYGQLQFQARDYSGTPYSQRDGYQQNY 309
|
330
....*....|.
gi 50428933 925 KRGGTSGGPRA 935
Cdd:pfam12287 310 KRGGTQSGPRA 320
|
|
| Caprin-1_dimer |
pfam18293 |
Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a ... |
200-315 |
1.79e-51 |
|
Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a role in many important biological processes, including cellular proliferation, innate immune response and synaptic plasticity. This domain is found in the highly conserved homologous region 1(HR1) and is responsible for the tight homodimerization of Caprin-1.
:
Pssm-ID: 436391 Cd Length: 116 Bit Score: 176.25 E-value: 1.79e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 200 RREHMLKLEAEKKKLRTILQVQYVLQNLTQEHVQKDFKGGLNGAVYLPSKELDYLIKFSKLTCPERNESLSVEDQMEQSS 279
Cdd:pfam18293 1 KKEAQLKMQAELARLREVLQVQDVLNSLGSEDVRNDFLNGTNGAVKLTEEDLKQLDEFYKLVGPKRDEDTSFADQMQKAA 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 50428933 280 LYFWDLLEGSEKAVVGTTYKHLKDLLSKLLNSGYFE 315
Cdd:pfam18293 81 EHLWALLEGKEKPVAGTTYKELKELLDKILNCGYFD 116
|
|
| C1q |
pfam00386 |
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement ... |
999-1124 |
6.60e-41 |
|
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement system.
:
Pssm-ID: 395310 [Multi-domain] Cd Length: 126 Bit Score: 146.66 E-value: 6.60e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 999 AFSAARTSNLAPGTlDQPIVFDLLLNNLGETFDLQLGRFNCPVNGTYVFIFHMLKLAvNVPLYVNLMKNEEVLVSAYAND 1078
Cdd:pfam00386 1 AFSAGRTTGLTAPN-EQPVRFDKVLTNIGGHYDPATGKFTCPVPGVYYFSYHITTVD-GKSLYVSLVKNGQEVVSFYDQP 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 50428933 1079 GAPDHETASNHAILQLFQGDQIWLRLH--RGAIYGSSWKYSTFSGYLL 1124
Cdd:pfam00386 79 QKGSLDVASGSVVLELQRGDEVWLQLTgyNGLYYDGSDTDSTFSGFLL 126
|
|
| SCP-1 super family |
cl30946 |
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ... |
88-540 |
3.41e-06 |
|
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.
The actual alignment was detected with superfamily member pfam05483:
Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 51.26 E-value: 3.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 88 QVNHSQHGESQRaLSPLQSTLSSAASPSQAYEtyiENGLICLKHKIRNIEKKKLKLEDyKDRLKSGEHLNPDQLEA-VEK 166
Cdd:pfam05483 286 ELIEKKDHLTKE-LEDIKMSLQRSMSTQKALE---EDLQIATKTICQLTEEKEAQMEE-LNKAKAAHSFVVTEFEAtTCS 360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 167 YEEVLHNLEfaKELQKTFSGLSLDLLKAQKKAQRREHMLKL----EAEKKKLRTILQVQYVL--QNLTQEHVQKDFKGG- 239
Cdd:pfam05483 361 LEELLRTEQ--QRLEKNEDQLKIITMELQKKSSELEEMTKFknnkEVELEELKKILAEDEKLldEKKQFEKIAEELKGKe 438
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 240 --LNGAVYLPSKEL-DYLIKFSKLTCPERNESLSVED---QMEQSSLYFWDLLEGSEKAVVGTT--YKHLKDLLSKLLNS 311
Cdd:pfam05483 439 qeLIFLLQAREKEIhDLEIQLTAIKTSEEHYLKEVEDlktELEKEKLKNIELTAHCDKLLLENKelTQEASDMTLELKKH 518
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 312 GyfESIpvpKNAKEKevplEEEMLIQ----SEKKTQL-SKTESVKEseslmEFAQP------EIQPQEFLNRRYMTEVDY 380
Cdd:pfam05483 519 Q--EDI---INCKKQ----EERMLKQienlEEKEMNLrDELESVRE-----EFIQKgdevkcKLDKSEENARSIEYEVLK 584
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 381 SNKQGEEQPWEADYARK--PNLPKRWDMLTEPDGQEKKQESFKSWEASGKHQEVSKPAVSLEQRKQDTSKLRSTLPEEQK 458
Cdd:pfam05483 585 KEKQMKILENKCNNLKKqiENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEIE 664
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 459 KQEISKSKpspsqwkqdtpkskagyVQEEQKKQETPKLWPVQLQKEQDPKKQTPkswTPSMQSEQNTTKSWTTPMCEEQD 538
Cdd:pfam05483 665 DKKISEEK-----------------LLEEVEKAKAIADEAVKLQKEIDKRCQHK---IAEMVALMEKHKHQYDKIIEERD 724
|
..
gi 50428933 539 SK 540
Cdd:pfam05483 725 SE 726
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Caprin-1_C |
pfam12287 |
Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is ... |
620-935 |
1.18e-172 |
|
Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is found in eukaryotes. Proteins in this family are typically between 343 and 708 amino acids in length. This family is the C terminal region of caprin-1. Caprin-1 is a protein involved in regulating cellular proliferation. In mutated phenotypes, the G1 phase of the cell cycle is greatly lengthened, impairing normal proliferation. The C terminal region of caprin-1 contains RGG motifs which are characteriztic of RNA binding domains. It is possible that caprin-1 functions through an RNA binding mechanism.
Pssm-ID: 463522 [Multi-domain] Cd Length: 320 Bit Score: 509.72 E-value: 1.18e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 620 LQDLMTQIQGTCNFMQESVLDFDKPS-SAIPTSQPPSATP-----GSPVASKEQNLSSQSDFLQEPLQATSSPVTCSSNA 693
Cdd:pfam12287 1 LQDLMAQIQGTYNFMQDSMLDFDKPSdSAIVSAQPPSQSPdlsqmVCPPASPEQRLSQQSDVLQQPEQTQVSPVSPSSNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 694 ClvttdqASSGSETEFMTSET--PEAAIPP---GKQPSSLASPNPPMAKGSE-QGFQSPPASSSSVTINTAPFQAMQTVF 767
Cdd:pfam12287 81 C------ASSGSEYQFHTSEPpqPEAIDPIqssMSLPSELAPPSPPLSPASQpQVFQSKPASSSGINVNAAPFQSMQTVF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 768 NVNAPLPPRKEQEIKE-SPYSPGYNQSFTTASTQTPPQCQLPSIHVEQTVhsqetAANYHPDGTIQVSNGSLAFYPAQTN 846
Cdd:pfam12287 155 NVNAPVPPRNEQELKEsSQYSSGYNQSFSSQSTQTVPQCQLPSEQLEQTV-----VGAYHPDGTIQVSNGHLAFYPAQTN 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 847 VFPRPTQPFVNSRGSVRGCTRGGRLITNSYRSPGGYK-GFDTYRG-LPSISNGNYSQLQFQAREYSGAPYSQRDNFQQCY 924
Cdd:pfam12287 230 GFPRPPQPFYNSRGSPRGGPRGGRGLMNGYRGPNGFKgGFDGYRGpFPNTPNGGYGQLQFQARDYSGTPYSQRDGYQQNY 309
|
330
....*....|.
gi 50428933 925 KRGGTSGGPRA 935
Cdd:pfam12287 310 KRGGTQSGPRA 320
|
|
| Caprin-1_dimer |
pfam18293 |
Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a ... |
200-315 |
1.79e-51 |
|
Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a role in many important biological processes, including cellular proliferation, innate immune response and synaptic plasticity. This domain is found in the highly conserved homologous region 1(HR1) and is responsible for the tight homodimerization of Caprin-1.
Pssm-ID: 436391 Cd Length: 116 Bit Score: 176.25 E-value: 1.79e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 200 RREHMLKLEAEKKKLRTILQVQYVLQNLTQEHVQKDFKGGLNGAVYLPSKELDYLIKFSKLTCPERNESLSVEDQMEQSS 279
Cdd:pfam18293 1 KKEAQLKMQAELARLREVLQVQDVLNSLGSEDVRNDFLNGTNGAVKLTEEDLKQLDEFYKLVGPKRDEDTSFADQMQKAA 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 50428933 280 LYFWDLLEGSEKAVVGTTYKHLKDLLSKLLNSGYFE 315
Cdd:pfam18293 81 EHLWALLEGKEKPVAGTTYKELKELLDKILNCGYFD 116
|
|
| C1q |
pfam00386 |
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement ... |
999-1124 |
6.60e-41 |
|
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement system.
Pssm-ID: 395310 [Multi-domain] Cd Length: 126 Bit Score: 146.66 E-value: 6.60e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 999 AFSAARTSNLAPGTlDQPIVFDLLLNNLGETFDLQLGRFNCPVNGTYVFIFHMLKLAvNVPLYVNLMKNEEVLVSAYAND 1078
Cdd:pfam00386 1 AFSAGRTTGLTAPN-EQPVRFDKVLTNIGGHYDPATGKFTCPVPGVYYFSYHITTVD-GKSLYVSLVKNGQEVVSFYDQP 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 50428933 1079 GAPDHETASNHAILQLFQGDQIWLRLH--RGAIYGSSWKYSTFSGYLL 1124
Cdd:pfam00386 79 QKGSLDVASGSVVLELQRGDEVWLQLTgyNGLYYDGSDTDSTFSGFLL 126
|
|
| C1Q |
smart00110 |
Complement component C1q domain; Globular domain found in many collagens and eponymously in ... |
993-1127 |
1.29e-32 |
|
Complement component C1q domain; Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tumour necrosis factor.
Pssm-ID: 128420 Cd Length: 135 Bit Score: 123.18 E-value: 1.29e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 993 PQQMRVAFSAARTSNLAPGtlDQPIVFDLLLNNLGETFDLQLGRFNCPVNGTYVFIFHMLKLAVNVplYVNLMKNEEVLV 1072
Cdd:smart00110 3 KAQPRSAFSVIRSNRPPPP--GQPIRFDKVLYNQQGHYDPRTGKFTCPVPGVYYFSYHVESKGRNV--KVSLMKNGIQVM 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 50428933 1073 SAYANDGAPDHETASNHAILQLFQGDQIWLRLHR--GAIYGSSWKYSTFSGYLLYQD 1127
Cdd:smart00110 79 STYDEYQKGLYDVASGGALLQLRQGDQVWLELPDekNGLYAGEYVDSTFSGFLLFPD 135
|
|
| SCP-1 |
pfam05483 |
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ... |
88-540 |
3.41e-06 |
|
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.
Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 51.26 E-value: 3.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 88 QVNHSQHGESQRaLSPLQSTLSSAASPSQAYEtyiENGLICLKHKIRNIEKKKLKLEDyKDRLKSGEHLNPDQLEA-VEK 166
Cdd:pfam05483 286 ELIEKKDHLTKE-LEDIKMSLQRSMSTQKALE---EDLQIATKTICQLTEEKEAQMEE-LNKAKAAHSFVVTEFEAtTCS 360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 167 YEEVLHNLEfaKELQKTFSGLSLDLLKAQKKAQRREHMLKL----EAEKKKLRTILQVQYVL--QNLTQEHVQKDFKGG- 239
Cdd:pfam05483 361 LEELLRTEQ--QRLEKNEDQLKIITMELQKKSSELEEMTKFknnkEVELEELKKILAEDEKLldEKKQFEKIAEELKGKe 438
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 240 --LNGAVYLPSKEL-DYLIKFSKLTCPERNESLSVED---QMEQSSLYFWDLLEGSEKAVVGTT--YKHLKDLLSKLLNS 311
Cdd:pfam05483 439 qeLIFLLQAREKEIhDLEIQLTAIKTSEEHYLKEVEDlktELEKEKLKNIELTAHCDKLLLENKelTQEASDMTLELKKH 518
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 312 GyfESIpvpKNAKEKevplEEEMLIQ----SEKKTQL-SKTESVKEseslmEFAQP------EIQPQEFLNRRYMTEVDY 380
Cdd:pfam05483 519 Q--EDI---INCKKQ----EERMLKQienlEEKEMNLrDELESVRE-----EFIQKgdevkcKLDKSEENARSIEYEVLK 584
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 381 SNKQGEEQPWEADYARK--PNLPKRWDMLTEPDGQEKKQESFKSWEASGKHQEVSKPAVSLEQRKQDTSKLRSTLPEEQK 458
Cdd:pfam05483 585 KEKQMKILENKCNNLKKqiENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEIE 664
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 459 KQEISKSKpspsqwkqdtpkskagyVQEEQKKQETPKLWPVQLQKEQDPKKQTPkswTPSMQSEQNTTKSWTTPMCEEQD 538
Cdd:pfam05483 665 DKKISEEK-----------------LLEEVEKAKAIADEAVKLQKEIDKRCQHK---IAEMVALMEKHKHQYDKIIEERD 724
|
..
gi 50428933 539 SK 540
Cdd:pfam05483 725 SE 726
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
130-569 |
2.03e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 45.90 E-value: 2.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 130 KHKIRNIEKK---KLKLEDYKDRL---KSGEHLNPDQLEAVEKYEEVLHNLEF---AKELQKTFSGLSLDLLKAQKKAQR 200
Cdd:PTZ00121 1456 AKKAEEAKKKaeeAKKADEAKKKAeeaKKADEAKKKAEEAKKKADEAKKAAEAkkkADEAKKAEEAKKADEAKKAEEAKK 1535
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 201 REHMLKLEaEKKKLRTILQVQYVLQnltQEHVQKdfkgglngavylpskeldylIKFSKLTCPERNESLSVEDQMEQssl 280
Cdd:PTZ00121 1536 ADEAKKAE-EKKKADELKKAEELKK---AEEKKK--------------------AEEAKKAEEDKNMALRKAEEAKK--- 1588
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 281 yfwdlLEGSEKAVVGTTYKHLKDLLSKLLNSGYFESIPVPKNAKEKEVPLEEEMLIQSEKKtQLSKTESVKESESLMEFA 360
Cdd:PTZ00121 1589 -----AEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAE-EKKKAEELKKAEEENKIK 1662
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 361 QPEIQPQEFLNRRYMTEVdySNKQGEEQPWEADYARKPNLPKRWDMLTEPDGQEKKQEsfkswEASGKHQEVSKPAVSLE 440
Cdd:PTZ00121 1663 AAEEAKKAEEDKKKAEEA--KKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKA-----EELKKAEEENKIKAEEA 1735
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 441 QRK--QDTSKLRSTLPEEQKKQEISKSKPSPSQWKQDTPKSKAGYVQEEQKKQETPKlwpvqlQKEQDPKKQTPKSWTPS 518
Cdd:PTZ00121 1736 KKEaeEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKR------RMEVDKKIKDIFDNFAN 1809
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 50428933 519 MQSEQNTTKSWTTPMCEEQDSKQPETPKS----WENNVESQKHSLTSQSQISPKS 569
Cdd:PTZ00121 1810 IIEGGKEGNLVINDSKEMEDSAIKEVADSknmqLEEADAFEKHKFNKNNENGEDG 1864
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
647-1012 |
3.37e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 45.16 E-value: 3.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 647 AIPTSQPPSATPGSPVAskeqnlssqsdflQEPLQATSSPVTCSSNACLVTT-DQASSGSETEFMTSETPEAAIPPGKQP 725
Cdd:PHA03307 61 ACDRFEPPTGPPPGPGT-------------EAPANESRSTPTWSLSTLAPASpAREGSPTPPGPSSPDPPPPTPPPASPP 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 726 SSLASPNPPMAKGSEQGFQSPPASSSSvtintapfqamqtvfnvnAPLPPRKEQEIKESPYSPGYNQSFTTASTQTPpqc 805
Cdd:PHA03307 128 PSPAPDLSEMLRPVGSPGPPPAASPPA------------------AGASPAAVASDAASSRQAALPLSSPEETARAP--- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 806 qlPSIHVEQTVHSQETAANYHP---DGTIQVSNGSLAFYPAQTNVFPRPTQPFVNSRGSVRGCTRGGRLITNSYRSPGGY 882
Cdd:PHA03307 187 --SSPPAEPPPSTPPAAASPRPprrSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPIT 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 883 KGFDTYRGLPSISNGNYSQLQFQA---REYSGAPYSQRDnfqqcyKRGGTSGGPRANSRAGWSDSSQVSSPERDNETFNS 959
Cdd:PHA03307 265 LPTRIWEASGWNGPSSRPGPASSSsspRERSPSPSPSSP------GSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRG 338
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 50428933 960 GDSGQGDSRSMTPVDVPVTNPAATilpvhvyPLPQQMRVAFSAARTSNLAPGT 1012
Cdd:PHA03307 339 AAVSPGPSPSRSPSPSRPPPPADP-------SSPRKRPRPSRAPSSPAASAGR 384
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Caprin-1_C |
pfam12287 |
Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is ... |
620-935 |
1.18e-172 |
|
Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is found in eukaryotes. Proteins in this family are typically between 343 and 708 amino acids in length. This family is the C terminal region of caprin-1. Caprin-1 is a protein involved in regulating cellular proliferation. In mutated phenotypes, the G1 phase of the cell cycle is greatly lengthened, impairing normal proliferation. The C terminal region of caprin-1 contains RGG motifs which are characteriztic of RNA binding domains. It is possible that caprin-1 functions through an RNA binding mechanism.
Pssm-ID: 463522 [Multi-domain] Cd Length: 320 Bit Score: 509.72 E-value: 1.18e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 620 LQDLMTQIQGTCNFMQESVLDFDKPS-SAIPTSQPPSATP-----GSPVASKEQNLSSQSDFLQEPLQATSSPVTCSSNA 693
Cdd:pfam12287 1 LQDLMAQIQGTYNFMQDSMLDFDKPSdSAIVSAQPPSQSPdlsqmVCPPASPEQRLSQQSDVLQQPEQTQVSPVSPSSNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 694 ClvttdqASSGSETEFMTSET--PEAAIPP---GKQPSSLASPNPPMAKGSE-QGFQSPPASSSSVTINTAPFQAMQTVF 767
Cdd:pfam12287 81 C------ASSGSEYQFHTSEPpqPEAIDPIqssMSLPSELAPPSPPLSPASQpQVFQSKPASSSGINVNAAPFQSMQTVF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 768 NVNAPLPPRKEQEIKE-SPYSPGYNQSFTTASTQTPPQCQLPSIHVEQTVhsqetAANYHPDGTIQVSNGSLAFYPAQTN 846
Cdd:pfam12287 155 NVNAPVPPRNEQELKEsSQYSSGYNQSFSSQSTQTVPQCQLPSEQLEQTV-----VGAYHPDGTIQVSNGHLAFYPAQTN 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 847 VFPRPTQPFVNSRGSVRGCTRGGRLITNSYRSPGGYK-GFDTYRG-LPSISNGNYSQLQFQAREYSGAPYSQRDNFQQCY 924
Cdd:pfam12287 230 GFPRPPQPFYNSRGSPRGGPRGGRGLMNGYRGPNGFKgGFDGYRGpFPNTPNGGYGQLQFQARDYSGTPYSQRDGYQQNY 309
|
330
....*....|.
gi 50428933 925 KRGGTSGGPRA 935
Cdd:pfam12287 310 KRGGTQSGPRA 320
|
|
| Caprin-1_dimer |
pfam18293 |
Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a ... |
200-315 |
1.79e-51 |
|
Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a role in many important biological processes, including cellular proliferation, innate immune response and synaptic plasticity. This domain is found in the highly conserved homologous region 1(HR1) and is responsible for the tight homodimerization of Caprin-1.
Pssm-ID: 436391 Cd Length: 116 Bit Score: 176.25 E-value: 1.79e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 200 RREHMLKLEAEKKKLRTILQVQYVLQNLTQEHVQKDFKGGLNGAVYLPSKELDYLIKFSKLTCPERNESLSVEDQMEQSS 279
Cdd:pfam18293 1 KKEAQLKMQAELARLREVLQVQDVLNSLGSEDVRNDFLNGTNGAVKLTEEDLKQLDEFYKLVGPKRDEDTSFADQMQKAA 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 50428933 280 LYFWDLLEGSEKAVVGTTYKHLKDLLSKLLNSGYFE 315
Cdd:pfam18293 81 EHLWALLEGKEKPVAGTTYKELKELLDKILNCGYFD 116
|
|
| C1q |
pfam00386 |
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement ... |
999-1124 |
6.60e-41 |
|
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement system.
Pssm-ID: 395310 [Multi-domain] Cd Length: 126 Bit Score: 146.66 E-value: 6.60e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 999 AFSAARTSNLAPGTlDQPIVFDLLLNNLGETFDLQLGRFNCPVNGTYVFIFHMLKLAvNVPLYVNLMKNEEVLVSAYAND 1078
Cdd:pfam00386 1 AFSAGRTTGLTAPN-EQPVRFDKVLTNIGGHYDPATGKFTCPVPGVYYFSYHITTVD-GKSLYVSLVKNGQEVVSFYDQP 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 50428933 1079 GAPDHETASNHAILQLFQGDQIWLRLH--RGAIYGSSWKYSTFSGYLL 1124
Cdd:pfam00386 79 QKGSLDVASGSVVLELQRGDEVWLQLTgyNGLYYDGSDTDSTFSGFLL 126
|
|
| C1Q |
smart00110 |
Complement component C1q domain; Globular domain found in many collagens and eponymously in ... |
993-1127 |
1.29e-32 |
|
Complement component C1q domain; Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tumour necrosis factor.
Pssm-ID: 128420 Cd Length: 135 Bit Score: 123.18 E-value: 1.29e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 993 PQQMRVAFSAARTSNLAPGtlDQPIVFDLLLNNLGETFDLQLGRFNCPVNGTYVFIFHMLKLAVNVplYVNLMKNEEVLV 1072
Cdd:smart00110 3 KAQPRSAFSVIRSNRPPPP--GQPIRFDKVLYNQQGHYDPRTGKFTCPVPGVYYFSYHVESKGRNV--KVSLMKNGIQVM 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 50428933 1073 SAYANDGAPDHETASNHAILQLFQGDQIWLRLHR--GAIYGSSWKYSTFSGYLLYQD 1127
Cdd:smart00110 79 STYDEYQKGLYDVASGGALLQLRQGDQVWLELPDekNGLYAGEYVDSTFSGFLLFPD 135
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
571-1001 |
2.75e-08 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 58.39 E-value: 2.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 571 GVATASLIPNDQLLPRklNTEPKDVPKPVHQPVGSSSTLPKDPVLRKEKLQDlmtqiqgtcNFMQESVLDFDKPSSAIPT 650
Cdd:pfam05109 447 GLPSSTHVPTNLTAPA--STGPTVSTADVTSPTPAGTTSGASPVTPSPSPRD---------NGTESKAPDMTSPTSAVTT 515
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 651 SQPPSATPGSPVASKEQNLSSqsdflqePLQATSSPVTCssnaclVTTDQASSGSETEFMTSETPEAAIPP-GK-QPSSL 728
Cdd:pfam05109 516 PTPNATSPTPAVTTPTPNATS-------PTLGKTSPTSA------VTTPTPNATSPTPAVTTPTPNATIPTlGKtSPTSA 582
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 729 ASPNPPMAKGSEQGFQSPPA---------SSSSVTINTAPFQAMQTVFNVNAPLPPRKEQEIKESPYSPGYNQSFTTAST 799
Cdd:pfam05109 583 VTTPTPNATSPTVGETSPQAnttnhtlggTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDN 662
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 800 QTPPQCQLPSIHveQTVHSQETAANYHPDGTIQVSNGSLAFYPAQTNVFPRPTQPFVNSRGSVRGCTRGGRLI-TNSYRS 878
Cdd:pfam05109 663 STSHMPLLTSAH--PTGGENITQVTPASTSTHHVSTSSPAPRPGTTSQASGPGNSSTSTKPGEVNVTKGTPPKnATSPQA 740
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 879 PGGYKgfdtyRGLPSI-SNGNYSQLQFQAREYSGapYSQRDNFQQCYKRGGTSGGPRANSRAGWSDSSQVSSPERDNETF 957
Cdd:pfam05109 741 PSGQK-----TAVPTVtSTGGKANSTTGGKHTTG--HGARTSTEPTTDYGGDSTTPRTRYNATTYLPPSTSSKLRPRWTF 813
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 50428933 958 NSGdsgqgdsrsmtpvdvPVTNPAATIlpvhvyPLPQQMRVAFS 1001
Cdd:pfam05109 814 TSP---------------PVTTAQATV------PVPPTSQPRFS 836
|
|
| SCP-1 |
pfam05483 |
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ... |
88-540 |
3.41e-06 |
|
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.
Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 51.26 E-value: 3.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 88 QVNHSQHGESQRaLSPLQSTLSSAASPSQAYEtyiENGLICLKHKIRNIEKKKLKLEDyKDRLKSGEHLNPDQLEA-VEK 166
Cdd:pfam05483 286 ELIEKKDHLTKE-LEDIKMSLQRSMSTQKALE---EDLQIATKTICQLTEEKEAQMEE-LNKAKAAHSFVVTEFEAtTCS 360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 167 YEEVLHNLEfaKELQKTFSGLSLDLLKAQKKAQRREHMLKL----EAEKKKLRTILQVQYVL--QNLTQEHVQKDFKGG- 239
Cdd:pfam05483 361 LEELLRTEQ--QRLEKNEDQLKIITMELQKKSSELEEMTKFknnkEVELEELKKILAEDEKLldEKKQFEKIAEELKGKe 438
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 240 --LNGAVYLPSKEL-DYLIKFSKLTCPERNESLSVED---QMEQSSLYFWDLLEGSEKAVVGTT--YKHLKDLLSKLLNS 311
Cdd:pfam05483 439 qeLIFLLQAREKEIhDLEIQLTAIKTSEEHYLKEVEDlktELEKEKLKNIELTAHCDKLLLENKelTQEASDMTLELKKH 518
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 312 GyfESIpvpKNAKEKevplEEEMLIQ----SEKKTQL-SKTESVKEseslmEFAQP------EIQPQEFLNRRYMTEVDY 380
Cdd:pfam05483 519 Q--EDI---INCKKQ----EERMLKQienlEEKEMNLrDELESVRE-----EFIQKgdevkcKLDKSEENARSIEYEVLK 584
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 381 SNKQGEEQPWEADYARK--PNLPKRWDMLTEPDGQEKKQESFKSWEASGKHQEVSKPAVSLEQRKQDTSKLRSTLPEEQK 458
Cdd:pfam05483 585 KEKQMKILENKCNNLKKqiENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEIE 664
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 459 KQEISKSKpspsqwkqdtpkskagyVQEEQKKQETPKLWPVQLQKEQDPKKQTPkswTPSMQSEQNTTKSWTTPMCEEQD 538
Cdd:pfam05483 665 DKKISEEK-----------------LLEEVEKAKAIADEAVKLQKEIDKRCQHK---IAEMVALMEKHKHQYDKIIEERD 724
|
..
gi 50428933 539 SK 540
Cdd:pfam05483 725 SE 726
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
382-802 |
3.72e-06 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 51.31 E-value: 3.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 382 NKQGEEQPWEADY---ARKPNLPKRWDMLTEPDGQEKKQESFKSWEASgkhQEVSKPAVSLEQRKQDTSKLRSTLPEEQK 458
Cdd:pfam03154 127 NDEGSSDPKDIDQdnrSTSPSIPSPQDNESDSDSSAQQQILQTQPPVL---QAQSGAASPPSPPPPGTTQAATAGPTPSA 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 459 KQEISKSKPSPSQwkqdTPKSKAGYVQEEQKKQETPKLWPVQLQKEQDPKKQTPKSWTPSMQSEQNTTKSW--------- 529
Cdd:pfam03154 204 PSVPPQGSPATSQ----PPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSlhgqmppmp 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 530 ---------------TTPMCEEQDSKQPETPKSWENNVESQKHsltsQSQISPKSWGVATASLIPNDQLLPRKLNTEPKD 594
Cdd:pfam03154 280 hslqtgpshmqhpvpPQPFPLTPQSSQSQVPPGPSPAAPGQSQ----QRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHI 355
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 595 VPKPvhqpvgsSSTLPKDPVLRKEKLQdlmTQIQGTCNFMQESVLDFD---KPSSAIPTSQPPSATPgSPVaskeqNLSS 671
Cdd:pfam03154 356 KPPP-------TTPIPQLPNPQSHKHP---PHLSGPSPFQMNSNLPPPpalKPLSSLSTHHPPSAHP-PPL-----QLMP 419
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 672 QSDFLQEPlqATSSPVTCSSNACLVTTDQASSGSETEFMTSETPEAAIP--PGKQPSSLASPNPPMAKGSEQGFQSPPAS 749
Cdd:pfam03154 420 QSQQLPPP--PAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPfvPGGPPPITPPSGPPTSTSSAMPGIQPPSS 497
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 50428933 750 SSSVTINTAPFQAMQTVFNVNAPLPPRKEQEIKESPYSPGYNQSFTTASTQTP 802
Cdd:pfam03154 498 ASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRSPSPEPTVVNTP 550
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
130-569 |
2.03e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 45.90 E-value: 2.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 130 KHKIRNIEKK---KLKLEDYKDRL---KSGEHLNPDQLEAVEKYEEVLHNLEF---AKELQKTFSGLSLDLLKAQKKAQR 200
Cdd:PTZ00121 1456 AKKAEEAKKKaeeAKKADEAKKKAeeaKKADEAKKKAEEAKKKADEAKKAAEAkkkADEAKKAEEAKKADEAKKAEEAKK 1535
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 201 REHMLKLEaEKKKLRTILQVQYVLQnltQEHVQKdfkgglngavylpskeldylIKFSKLTCPERNESLSVEDQMEQssl 280
Cdd:PTZ00121 1536 ADEAKKAE-EKKKADELKKAEELKK---AEEKKK--------------------AEEAKKAEEDKNMALRKAEEAKK--- 1588
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 281 yfwdlLEGSEKAVVGTTYKHLKDLLSKLLNSGYFESIPVPKNAKEKEVPLEEEMLIQSEKKtQLSKTESVKESESLMEFA 360
Cdd:PTZ00121 1589 -----AEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAE-EKKKAEELKKAEEENKIK 1662
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 361 QPEIQPQEFLNRRYMTEVdySNKQGEEQPWEADYARKPNLPKRWDMLTEPDGQEKKQEsfkswEASGKHQEVSKPAVSLE 440
Cdd:PTZ00121 1663 AAEEAKKAEEDKKKAEEA--KKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKA-----EELKKAEEENKIKAEEA 1735
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 441 QRK--QDTSKLRSTLPEEQKKQEISKSKPSPSQWKQDTPKSKAGYVQEEQKKQETPKlwpvqlQKEQDPKKQTPKSWTPS 518
Cdd:PTZ00121 1736 KKEaeEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKR------RMEVDKKIKDIFDNFAN 1809
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 50428933 519 MQSEQNTTKSWTTPMCEEQDSKQPETPKS----WENNVESQKHSLTSQSQISPKS 569
Cdd:PTZ00121 1810 IIEGGKEGNLVINDSKEMEDSAIKEVADSknmqLEEADAFEKHKFNKNNENGEDG 1864
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
647-1012 |
3.37e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 45.16 E-value: 3.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 647 AIPTSQPPSATPGSPVAskeqnlssqsdflQEPLQATSSPVTCSSNACLVTT-DQASSGSETEFMTSETPEAAIPPGKQP 725
Cdd:PHA03307 61 ACDRFEPPTGPPPGPGT-------------EAPANESRSTPTWSLSTLAPASpAREGSPTPPGPSSPDPPPPTPPPASPP 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 726 SSLASPNPPMAKGSEQGFQSPPASSSSvtintapfqamqtvfnvnAPLPPRKEQEIKESPYSPGYNQSFTTASTQTPpqc 805
Cdd:PHA03307 128 PSPAPDLSEMLRPVGSPGPPPAASPPA------------------AGASPAAVASDAASSRQAALPLSSPEETARAP--- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 806 qlPSIHVEQTVHSQETAANYHP---DGTIQVSNGSLAFYPAQTNVFPRPTQPFVNSRGSVRGCTRGGRLITNSYRSPGGY 882
Cdd:PHA03307 187 --SSPPAEPPPSTPPAAASPRPprrSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPIT 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 883 KGFDTYRGLPSISNGNYSQLQFQA---REYSGAPYSQRDnfqqcyKRGGTSGGPRANSRAGWSDSSQVSSPERDNETFNS 959
Cdd:PHA03307 265 LPTRIWEASGWNGPSSRPGPASSSsspRERSPSPSPSSP------GSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRG 338
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 50428933 960 GDSGQGDSRSMTPVDVPVTNPAATilpvhvyPLPQQMRVAFSAARTSNLAPGT 1012
Cdd:PHA03307 339 AAVSPGPSPSRSPSPSRPPPPADP-------SSPRKRPRPSRAPSSPAASAGR 384
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
647-808 |
4.92e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 44.54 E-value: 4.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 647 AIPTSQPPSATPGSPVASkeqnLSSQSDFLQEPLQATSSPVTCSSNACLVTTDQASSGSETEFMTSETPEAAIPPGKQPS 726
Cdd:PHA03247 2773 AAPAAGPPRRLTRPAVAS----LSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPP 2848
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 727 SLaSPNPPMAKGSEqgFQSPPASSSSVTINTAPfqAMQTVFNVNAPLPPRKEQEIKESPYSPgynQSFTTASTQTPPQCQ 806
Cdd:PHA03247 2849 SL-PLGGSVAPGGD--VRRRPPSRSPAAKPAAP--ARPPVRRLARPAVSRSTESFALPPDQP---ERPPQPQAPPPPQPQ 2920
|
..
gi 50428933 807 LP 808
Cdd:PHA03247 2921 PQ 2922
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
463-858 |
1.81e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 42.45 E-value: 1.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 463 SKSKPSPSQWKQDTPKSKAGYVQEEQKKQETPKLWPVQLQKEQDPKKQTPKSWTPSMQSEQNTTKSWTTP---------- 532
Cdd:pfam03154 41 SSGRNSPSAASTSSNDSKAESMKKSSKKIKEEAPSPLKSAKRQREKGASDTEEPERATAKKSKTQEISRPnspsegeges 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 533 ----------------MCEEQDSKQPETPKSWENNVESQKHSLTSQSQISPKSWGVATASLIPnDQLLPRKLNTEPKDVP 596
Cdd:pfam03154 121 sdgrsvndegssdpkdIDQDNRSTSPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASP-PSPPPPGTTQAATAGP 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 597 KPVHQPVGSSSTLP-KDPVLRKEKLQDLMTQIQGTCNFMQESVLDFDKPSSAIPTSQPPSATPGSPVASKE--------- 666
Cdd:pfam03154 200 TPSAPSVPPQGSPAtSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSlhgqmppmp 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 667 QNLSSQSDFLQEPLQATSSPVTCSSNACLV--TTDQASSGSETEFMTSETPEAAIPPGKQPSSLASPNPPMAK------- 737
Cdd:pfam03154 280 HSLQTGPSHMQHPVPPQPFPLTPQSSQSQVppGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMphikppp 359
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428933 738 -------GSEQGFQSPPASSSSvtintAPFQamqtvFNVNAPLPPRKEQEIKESPYSPgynQSFTTASTQTPPQCQ-LPS 809
Cdd:pfam03154 360 ttpipqlPNPQSHKHPPHLSGP-----SPFQ-----MNSNLPPPPALKPLSSLSTHHP---PSAHPPPLQLMPQSQqLPP 426
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 50428933 810 IHVEQTVHSQetAANYHPDGTIQVSNGSLAFYPAQTnvfPRPTQPFVNS 858
Cdd:pfam03154 427 PPAQPPVLTQ--SQSLPPPAASHPPTSGLHQVPSQS---PFPQHPFVPG 470
|
|
| |
