NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|50312664|ref|NP_001001992|]
View 

ubiquitin carboxyl-terminal hydrolase 16 isoform b [Homo sapiens]

Protein Classification

zf-UBP and Peptidase_C19K domain-containing protein( domain architecture ID 10489803)

zf-UBP and Peptidase_C19K domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Peptidase_C19K cd02667
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 622-819 9.07e-85

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


:

Pssm-ID: 239132 [Multi-domain]  Cd Length: 279  Bit Score: 271.57  E-value: 9.07e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 622 REVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRrqcngpkanikgerkhvytnAKKQMLISLAPPVLTLHLKRFQQ 701
Cdd:cd02667 103 RSDEIKSECSIESCLKQFTEVEILEGNNKFACENCTK--------------------AKKQYLISKLPPVLVIHLKRFQQ 162

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 702 AGF-NLRKVNKHIKFPEILDLAPFCTLKCkNVAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHgDI 780
Cdd:cd02667 163 PRSaNLRKVSRHVSFPEILDLAPFCDPKC-NSSEDKSSVLYRLYGVVEHSGTMRSGHYVAYVKVRPPQQRLSDLTKS-KP 240

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 50312664 781 PQDFEMESKGQWFHISDTHVQAVPTTKVLNSQAYLLFYE 819
Cdd:cd02667 241 AADEAGPGSGQWYYISDSDVREVSLEEVLKSEAYLLFYE 279
Peptidase_C19 super family cl02553
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ...
 196-401 4.82e-49

Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


The actual alignment was detected with superfamily member cd02667:

Pssm-ID: 470612 [Multi-domain]  Cd Length: 279  Bit Score: 174.50  E-value: 4.82e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 196 GLSNLGNTCFFNAVMQNLSQTPVLRELLKEvkmsgtivkieppdlaltepleinleppgpltlamsqflnemqetkkgvv 275
Cdd:cd02667   1 GLSNLGNTCFFNAVMQNLSQTPALRELLSE-------------------------------------------------- 30

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 276 TPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRaeehqrvskgilkafgnstekldeelknkvkdyekkksmpSFVD 355
Cdd:cd02667  31 TPKELFSQVCRKAPQFKGYQQQDSHELLRYLLDGLR----------------------------------------TFID 70

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 50312664 356 RIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSVNDK 401
Cdd:cd02667  71 SIFGGELTSTIMCESCGTVSLVYEPFLDLSLPRSDEIKSECSIESC 116
zf-UBP pfam02148
Zn-finger in ubiquitin-hydrolases and other protein;
48-123 6.48e-20

Zn-finger in ubiquitin-hydrolases and other protein;


:

Pssm-ID: 460464  Cd Length: 63  Bit Score: 83.85  E-value: 6.48e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 50312664    48 CQDCKTDNkvkdkaeeeteekpSVWLCLKCGHQGCGRnSQEQHALKHYLTPRsepHCLVLSLDNWSVWCYVCDNEV 123
Cdd:pfam02148   1 CSLCGNTS--------------NLWLCLTCGHVGCGR-YQNSHALEHYEETG---HPLAVNLSTLTVYCYPCDDYV 58
 
Name Accession Description Interval E-value
Peptidase_C19K cd02667
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 622-819 9.07e-85

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239132 [Multi-domain]  Cd Length: 279  Bit Score: 271.57  E-value: 9.07e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 622 REVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRrqcngpkanikgerkhvytnAKKQMLISLAPPVLTLHLKRFQQ 701
Cdd:cd02667 103 RSDEIKSECSIESCLKQFTEVEILEGNNKFACENCTK--------------------AKKQYLISKLPPVLVIHLKRFQQ 162

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 702 AGF-NLRKVNKHIKFPEILDLAPFCTLKCkNVAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHgDI 780
Cdd:cd02667 163 PRSaNLRKVSRHVSFPEILDLAPFCDPKC-NSSEDKSSVLYRLYGVVEHSGTMRSGHYVAYVKVRPPQQRLSDLTKS-KP 240

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 50312664 781 PQDFEMESKGQWFHISDTHVQAVPTTKVLNSQAYLLFYE 819
Cdd:cd02667 241 AADEAGPGSGQWYYISDSDVREVSLEEVLKSEAYLLFYE 279
Peptidase_C19K cd02667
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 196-401 4.82e-49

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239132 [Multi-domain]  Cd Length: 279  Bit Score: 174.50  E-value: 4.82e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 196 GLSNLGNTCFFNAVMQNLSQTPVLRELLKEvkmsgtivkieppdlaltepleinleppgpltlamsqflnemqetkkgvv 275
Cdd:cd02667   1 GLSNLGNTCFFNAVMQNLSQTPALRELLSE-------------------------------------------------- 30

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 276 TPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRaeehqrvskgilkafgnstekldeelknkvkdyekkksmpSFVD 355
Cdd:cd02667  31 TPKELFSQVCRKAPQFKGYQQQDSHELLRYLLDGLR----------------------------------------TFID 70

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 50312664 356 RIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSVNDK 401
Cdd:cd02667  71 SIFGGELTSTIMCESCGTVSLVYEPFLDLSLPRSDEIKSECSIESC 116
UBP12 COG5560
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
196-820 2.43e-35

Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227847 [Multi-domain]  Cd Length: 823  Bit Score: 144.26  E-value: 2.43e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 196 GLSNLGNTCFFNAVMQNLSQTPVLRE--LLKEVKMsgtivkieppdlalteplEINLEPP----GPLTLAMSQFLNEMQE 269
Cdd:COG5560 267 GLRNLGNTCYMNSALQCLMHTWELRDyfLSDEYEE------------------SINEENPlgmhGSVASAYADLIKQLYD 328

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 270 TKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMraeeHQRVSKGILKAFG---NSTEKLDEELKNKVKD--Y 344
Cdd:COG5560 329 GNLHAFTPSGFKKTIGSFNEEFSGYDQQDSQEFIAFLLDGL----HEDLNRIIKKPYTskpDLSPGDDVVVKKKAKEcwW 404

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 345 EKKKSMPSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSV-----NDKNLKKTVEDEDQDSEEEKD 419
Cdd:COG5560 405 EHLKRNDSIITDLFQGMYKSTLTCPGCGSVSITFDPFMDLTLPLPVSMVWKHTIvvfpeSGRRQPLKIELDASSTIRGLK 484

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 420 NdsYIKERSDIpSGTSKHLQKKAKKQAKKQAKNQrrqqkiQGKVLhLNDIctidHPEDSEYEAEMSLQG------EVNIK 493
Cdd:COG5560 485 K--LVDAEYGK-LGCFEIKVMCIYYGGNYNMLEP------ADKVL-LQDI----PQTDFVYLYETNDNGievpvvHLRIE 550

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 494 SNHISQEGVMHKEYCVNQKDLN-GQAKMIESVtdnQKSTEEVDMKNINMDNDLEVLTSSPTRNLNGAYL---TEGSNGEV 569
Cdd:COG5560 551 KGYKSKRLFGDPFLQLNVLIKAsIYDKLVKEF---EELLVLVEMKKTDVDLVSEQVRLLREESSPSSWLkleTEIDTKRE 627

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 570 DISNgfknlNLNAALHPDEINIEILNdshtPGTKVYEVVNEDpetafCTLANREVFNTDEC-SIQHCLYQFTRNEKLRDA 648
Cdd:COG5560 628 EQVE-----EEGQMNFNDAVVISCEW----EEKRYLSLFSYD-----PLWTIREIGAAERTiTLQDCLNEFSKPEQLGLS 693

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 649 NKLLCEVCtrrqcngpkaniKGERKhvytnAKKQMLISLAPPVLTLHLKRFQQAGFNLRKVNKHIKFPeILDLapfcTLK 728
Cdd:COG5560 694 DSWYCPGC------------KEFRQ-----ASKQMELWRLPMILIIHLKRFSSVRSFRDKIDDLVEYP-IDDL----DLS 751

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 729 CKNVAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKArtanshlsnlvlhgdipqdfemESKGQWFHISDTHVQAVPTTKV 808
Cdd:COG5560 752 GVEYMVDDPRLIYDLYAVDNHYGGLSGGHYTAYARN----------------------FANNGWYLFDDSRITEVDPEDS 809

                       650
                ....*....|..
gi 50312664 809 LNSQAYLLFYER 820
Cdd:COG5560 810 VTSSAYVLFYRR 821
UCH pfam00443
Ubiquitin carboxyl-terminal hydrolase;
631-818 9.88e-34

Ubiquitin carboxyl-terminal hydrolase;


Pssm-ID: 425685 [Multi-domain]  Cd Length: 310  Bit Score: 131.80  E-value: 9.88e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664   631 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQcngpkanikgerkhvytNAKKQMLISLAPPVLTLHLKRFQQAGFNLRKVN 710
Cdd:pfam00443 163 SLQICFLQFSKLEELDDEEKYYCDKCGCKQ-----------------DAIKQLKISRLPPVLIIHLKRFSYNRSTWEKLN 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664   711 KHIKFPEILDLAPFCTLKCKnvAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKArtanshlsnlvlhgdipqdfemESKG 790
Cdd:pfam00443 226 TEVEFPLELDLSRYLAEELK--PKTNNLQDYRLVAVVVHSGSLSSGHYIAYIKA----------------------YENN 281

                         170       180
                  ....*....|....*....|....*....
gi 50312664   791 QWFHISDTHVQAV-PTTKVLNSQAYLLFY 818
Cdd:pfam00443 282 RWYKFDDEKVTEVdEETAVLSSSAYILFY 310
UCH pfam00443
Ubiquitin carboxyl-terminal hydrolase;
196-393 2.60e-26

Ubiquitin carboxyl-terminal hydrolase;


Pssm-ID: 425685 [Multi-domain]  Cd Length: 310  Bit Score: 110.22  E-value: 2.60e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664   196 GLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKieppdlaltEPLEINLeppgplTLAMSQFLNEMQE-TKKGV 274
Cdd:pfam00443   2 GLVNLGNTCYMNSVLQSLFSIPPFRDYLLRISPLSEDSR---------YNKDINL------LCALRDLFKALQKnSKSSS 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664   275 VTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGmraeehqrvskgilkafgnstekLDEELKNKVkdyekKKSMPSFV 354
Cdd:pfam00443  67 VSPKMFKKSLGKLNPDFSGYKQQDAQEFLLFLLDG-----------------------LHEDLNGNH-----STENESLI 118

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 50312664   355 DRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQS 393
Cdd:pfam00443 119 TDLFRGQLKSRLKCLSCGEVSETFEPFSDLSLPIPGDSA 157
zf-UBP pfam02148
Zn-finger in ubiquitin-hydrolases and other protein;
48-123 6.48e-20

Zn-finger in ubiquitin-hydrolases and other protein;


Pssm-ID: 460464  Cd Length: 63  Bit Score: 83.85  E-value: 6.48e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 50312664    48 CQDCKTDNkvkdkaeeeteekpSVWLCLKCGHQGCGRnSQEQHALKHYLTPRsepHCLVLSLDNWSVWCYVCDNEV 123
Cdd:pfam02148   1 CSLCGNTS--------------NLWLCLTCGHVGCGR-YQNSHALEHYEETG---HPLAVNLSTLTVYCYPCDDYV 58
ZnF_UBP smart00290
Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger;
47-114 2.62e-08

Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger;


Pssm-ID: 197632  Cd Length: 50  Bit Score: 50.83  E-value: 2.62e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 50312664     47 ICQDCKTDNKVkdkaeeeteekpsvWLCLKCGHQGCGRnSQEQHALKHYltpRSEPHCLVLSLDNWSV 114
Cdd:smart00290   1 RCSVCGTIENL--------------WLCLTCGQVGCGR-YQNGHALEHF---EETGHPLVVKLGTQRV 50
 
Name Accession Description Interval E-value
Peptidase_C19K cd02667
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 622-819 9.07e-85

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239132 [Multi-domain]  Cd Length: 279  Bit Score: 271.57  E-value: 9.07e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 622 REVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRrqcngpkanikgerkhvytnAKKQMLISLAPPVLTLHLKRFQQ 701
Cdd:cd02667 103 RSDEIKSECSIESCLKQFTEVEILEGNNKFACENCTK--------------------AKKQYLISKLPPVLVIHLKRFQQ 162

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 702 AGF-NLRKVNKHIKFPEILDLAPFCTLKCkNVAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHgDI 780
Cdd:cd02667 163 PRSaNLRKVSRHVSFPEILDLAPFCDPKC-NSSEDKSSVLYRLYGVVEHSGTMRSGHYVAYVKVRPPQQRLSDLTKS-KP 240

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 50312664 781 PQDFEMESKGQWFHISDTHVQAVPTTKVLNSQAYLLFYE 819
Cdd:cd02667 241 AADEAGPGSGQWYYISDSDVREVSLEEVLKSEAYLLFYE 279
Peptidase_C19K cd02667
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 196-401 4.82e-49

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239132 [Multi-domain]  Cd Length: 279  Bit Score: 174.50  E-value: 4.82e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 196 GLSNLGNTCFFNAVMQNLSQTPVLRELLKEvkmsgtivkieppdlaltepleinleppgpltlamsqflnemqetkkgvv 275
Cdd:cd02667   1 GLSNLGNTCFFNAVMQNLSQTPALRELLSE-------------------------------------------------- 30

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 276 TPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRaeehqrvskgilkafgnstekldeelknkvkdyekkksmpSFVD 355
Cdd:cd02667  31 TPKELFSQVCRKAPQFKGYQQQDSHELLRYLLDGLR----------------------------------------TFID 70

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 50312664 356 RIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSVNDK 401
Cdd:cd02667  71 SIFGGELTSTIMCESCGTVSLVYEPFLDLSLPRSDEIKSECSIESC 116
Peptidase_C19 cd02257
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ...
 624-819 1.30e-39

Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239072 [Multi-domain]  Cd Length: 255  Bit Score: 147.24  E-value: 1.30e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 624 VFNTDECSIQHCLYQFTRNEKLRDANKLLCEvctrrqcngpkanikgerKHVYTNAKKQMLISLAPPVLTLHLKRFQQAG 703
Cdd:cd02257  93 VKGLPQVSLEDCLEKFFKEEILEGDNCYKCE------------------KKKKQEATKRLKIKKLPPVLIIHLKRFSFNE 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 704 -FNLRKVNKHIKFPEILDLAPFCTLKCKNVAEENTRVLYSLYGVVEHSGT-MRSGHYTAYAKartanshlsnlvlhgdip 781
Cdd:cd02257 155 dGTKEKLNTKVSFPLELDLSPYLSEGEKDSDSDNGSYKYELVAVVVHSGTsADSGHYVAYVK------------------ 216

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 50312664 782 qdfeMESKGQWFHISDTHVQAVPTTKVL-----NSQAYLLFYE 819
Cdd:cd02257 217 ----DPSDGKWYKFNDDKVTEVSEEEVLefgslSSSAYILFYE 255
Peptidase_C19E cd02661
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 631-818 8.32e-39

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239126 [Multi-domain]  Cd Length: 304  Bit Score: 146.27  E-value: 8.32e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 631 SIQHCLYQFTRNEKLRDANKLLCEVCTRrqcngpkanikgerkhvYTNAKKQMLISLAPPVLTLHLKRFQqaGFNLRKVN 710
Cdd:cd02661 163 SLEDALEQFTKPEQLDGENKYKCERCKK-----------------KVKASKQLTIHRAPNVLTIHLKRFS--NFRGGKIN 223

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 711 KHIKFPEILDLAPFCTlkckNVAEENTRvlYSLYGVVEHSGT-MRSGHYTAYAKArtanshlsnlvlhgdipqdfemeSK 789
Cdd:cd02661 224 KQISFPETLDLSPYMS----QPNDGPLK--YKLYAVLVHSGFsPHSGHYYCYVKS-----------------------SN 274

                       170       180
                ....*....|....*....|....*....
gi 50312664 790 GQWFHISDTHVQAVPTTKVLNSQAYLLFY 818
Cdd:cd02661 275 GKWYNMDDSKVSPVSIETVLSQKAYILFY 303
UBP12 COG5560
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
196-820 2.43e-35

Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227847 [Multi-domain]  Cd Length: 823  Bit Score: 144.26  E-value: 2.43e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 196 GLSNLGNTCFFNAVMQNLSQTPVLRE--LLKEVKMsgtivkieppdlalteplEINLEPP----GPLTLAMSQFLNEMQE 269
Cdd:COG5560 267 GLRNLGNTCYMNSALQCLMHTWELRDyfLSDEYEE------------------SINEENPlgmhGSVASAYADLIKQLYD 328

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 270 TKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMraeeHQRVSKGILKAFG---NSTEKLDEELKNKVKD--Y 344
Cdd:COG5560 329 GNLHAFTPSGFKKTIGSFNEEFSGYDQQDSQEFIAFLLDGL----HEDLNRIIKKPYTskpDLSPGDDVVVKKKAKEcwW 404

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 345 EKKKSMPSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSV-----NDKNLKKTVEDEDQDSEEEKD 419
Cdd:COG5560 405 EHLKRNDSIITDLFQGMYKSTLTCPGCGSVSITFDPFMDLTLPLPVSMVWKHTIvvfpeSGRRQPLKIELDASSTIRGLK 484

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 420 NdsYIKERSDIpSGTSKHLQKKAKKQAKKQAKNQrrqqkiQGKVLhLNDIctidHPEDSEYEAEMSLQG------EVNIK 493
Cdd:COG5560 485 K--LVDAEYGK-LGCFEIKVMCIYYGGNYNMLEP------ADKVL-LQDI----PQTDFVYLYETNDNGievpvvHLRIE 550

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 494 SNHISQEGVMHKEYCVNQKDLN-GQAKMIESVtdnQKSTEEVDMKNINMDNDLEVLTSSPTRNLNGAYL---TEGSNGEV 569
Cdd:COG5560 551 KGYKSKRLFGDPFLQLNVLIKAsIYDKLVKEF---EELLVLVEMKKTDVDLVSEQVRLLREESSPSSWLkleTEIDTKRE 627

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 570 DISNgfknlNLNAALHPDEINIEILNdshtPGTKVYEVVNEDpetafCTLANREVFNTDEC-SIQHCLYQFTRNEKLRDA 648
Cdd:COG5560 628 EQVE-----EEGQMNFNDAVVISCEW----EEKRYLSLFSYD-----PLWTIREIGAAERTiTLQDCLNEFSKPEQLGLS 693

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 649 NKLLCEVCtrrqcngpkaniKGERKhvytnAKKQMLISLAPPVLTLHLKRFQQAGFNLRKVNKHIKFPeILDLapfcTLK 728
Cdd:COG5560 694 DSWYCPGC------------KEFRQ-----ASKQMELWRLPMILIIHLKRFSSVRSFRDKIDDLVEYP-IDDL----DLS 751

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 729 CKNVAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKArtanshlsnlvlhgdipqdfemESKGQWFHISDTHVQAVPTTKV 808
Cdd:COG5560 752 GVEYMVDDPRLIYDLYAVDNHYGGLSGGHYTAYARN----------------------FANNGWYLFDDSRITEVDPEDS 809

                       650
                ....*....|..
gi 50312664 809 LNSQAYLLFYER 820
Cdd:COG5560 810 VTSSAYVLFYRR 821
UCH pfam00443
Ubiquitin carboxyl-terminal hydrolase;
631-818 9.88e-34

Ubiquitin carboxyl-terminal hydrolase;


Pssm-ID: 425685 [Multi-domain]  Cd Length: 310  Bit Score: 131.80  E-value: 9.88e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664   631 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQcngpkanikgerkhvytNAKKQMLISLAPPVLTLHLKRFQQAGFNLRKVN 710
Cdd:pfam00443 163 SLQICFLQFSKLEELDDEEKYYCDKCGCKQ-----------------DAIKQLKISRLPPVLIIHLKRFSYNRSTWEKLN 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664   711 KHIKFPEILDLAPFCTLKCKnvAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKArtanshlsnlvlhgdipqdfemESKG 790
Cdd:pfam00443 226 TEVEFPLELDLSRYLAEELK--PKTNNLQDYRLVAVVVHSGSLSSGHYIAYIKA----------------------YENN 281

                         170       180
                  ....*....|....*....|....*....
gi 50312664   791 QWFHISDTHVQAV-PTTKVLNSQAYLLFY 818
Cdd:pfam00443 282 RWYKFDDEKVTEVdEETAVLSSSAYILFY 310
Peptidase_C19R cd02674
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 626-819 1.11e-33

A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239139 [Multi-domain]  Cd Length: 230  Bit Score: 129.33  E-value: 1.11e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 626 NTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRRQCngpkanikgerkhvytnAKKQMLISLAPPVLTLHLKRFQQAGFN 705
Cdd:cd02674  80 DAPKVTLEDCLRLFTKEETLDGDNAWKCPKCKKKRK-----------------ATKKLTISRLPKVLIIHLKRFSFSRGS 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 706 LRKVNKHIKFP-EILDLAPFCtlkckNVAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKArtanshlsnlvlhgdipqdf 784
Cdd:cd02674 143 TRKLTTPVTFPlNDLDLTPYV-----DTRSFTGPFKYDLYAVVNHYGSLNGGHYTAYCKN-------------------- 197

                       170       180       190
                ....*....|....*....|....*....|....*
gi 50312664 785 emESKGQWFHISDTHVQAVPTTKVLNSQAYLLFYE 819
Cdd:cd02674 198 --NETNDWYKFDDSRVTKVSESSVVSSSAYILFYE 230
Peptidase_C19D cd02660
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 626-818 4.98e-29

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239125 [Multi-domain]  Cd Length: 328  Bit Score: 118.63  E-value: 4.98e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 626 NTDECSIQHCLYQFTRNEKLRDANkLLCEVCtrrqcngpkanikgerkHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFN 705
Cdd:cd02660 172 VSGTPTLSDCLDRFTRPEKLGDFA-YKCSGC-----------------GSTQEATKQLSIKKLPPVLCFQLKRFEHSLNK 233

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 706 L-RKVNKHIKFPEILDLAPFCTLKCKNVAEEN---TRVLYSLYGVVEHSGTMRSGHYTAYAKARtanshlsnlvlhgdip 781
Cdd:cd02660 234 TsRKIDTYVQFPLELNMTPYTSSSIGDTQDSNsldPDYTYDLFAVVVHKGTLDTGHYTAYCRQG---------------- 297

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 50312664 782 qdfemesKGQWFHISDTHVQAVPTTKVLNSQAYLLFY 818
Cdd:cd02660 298 -------DGQWFKFDDAMITRVSEEEVLKSQAYLLFY 327
UCH pfam00443
Ubiquitin carboxyl-terminal hydrolase;
196-393 2.60e-26

Ubiquitin carboxyl-terminal hydrolase;


Pssm-ID: 425685 [Multi-domain]  Cd Length: 310  Bit Score: 110.22  E-value: 2.60e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664   196 GLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKieppdlaltEPLEINLeppgplTLAMSQFLNEMQE-TKKGV 274
Cdd:pfam00443   2 GLVNLGNTCYMNSVLQSLFSIPPFRDYLLRISPLSEDSR---------YNKDINL------LCALRDLFKALQKnSKSSS 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664   275 VTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGmraeehqrvskgilkafgnstekLDEELKNKVkdyekKKSMPSFV 354
Cdd:pfam00443  67 VSPKMFKKSLGKLNPDFSGYKQQDAQEFLLFLLDG-----------------------LHEDLNGNH-----STENESLI 118

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 50312664   355 DRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQS 393
Cdd:pfam00443 119 TDLFRGQLKSRLKCLSCGEVSETFEPFSDLSLPIPGDSA 157
peptidase_C19C cd02659
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 631-821 5.40e-24

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239124 [Multi-domain]  Cd Length: 334  Bit Score: 103.88  E-value: 5.40e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 631 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQcngpkanikgerkhvytNAKKQMLISLAPPVLTLHLKRFQqagFNL---- 706
Cdd:cd02659 152 NLEESLDAYVQGETLEGDNKYFCEKCGKKV-----------------DAEKGVCFKKLPPVLTLQLKRFE---FDFetmm 211

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 707 -RKVNKHIKFPEILDLAPFC--TLKCKNVAEENTRV---LYSLYGVVEHSGTMRSGHYTAYAKARTanshlsnlvlhgdi 780
Cdd:cd02659 212 rIKINDRFEFPLELDMEPYTekGLAKKEGDSEKKDSesyIYELHGVLVHSGDAHGGHYYSYIKDRD-------------- 277

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 50312664 781 pqdfemesKGQWFHISDTHV----------------------QAVPTTKVLNSQAYLLFYERI 821
Cdd:cd02659 278 --------DGKWYKFNDDVVtpfdpndaeeecfggeetqktyDSGPRAFKRTTNAYMLFYERK 332
Peptidase_C19F cd02662
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 630-819 1.47e-21

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239127 [Multi-domain]  Cd Length: 240  Bit Score: 94.36  E-value: 1.47e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 630 CSIQHCLYQFTRNEKLRDANkllCEVCtrrqcngpkanikgerkhvytnakkQMLISLAPPVLTLHLKRFQQAGFN-LRK 708
Cdd:cd02662  96 TTLEHCLDDFLSTEIIDDYK---CDRC-------------------------QTVIVRLPQILCIHLSRSVFDGRGtSTK 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 709 VNKHIKFPEILdlapfctlkcknvaeenTRVLYSLYGVVEHSGTMRSGHYTAYAKARTanSHLSNLVLHGDIPQDFEMES 788
Cdd:cd02662 148 NSCKVSFPERL-----------------PKVLYRLRAVVVHYGSHSSGHYVCYRRKPL--FSKDKEPGSFVRMREGPSST 208

                       170       180       190
                ....*....|....*....|....*....|..
gi 50312664 789 KGQWFHISDTHVQAVPTTKVL-NSQAYLLFYE 819
Cdd:cd02662 209 SHPWWRISDTTVKEVSESEVLeQKSAYMLFYE 240
zf-UBP pfam02148
Zn-finger in ubiquitin-hydrolases and other protein;
48-123 6.48e-20

Zn-finger in ubiquitin-hydrolases and other protein;


Pssm-ID: 460464  Cd Length: 63  Bit Score: 83.85  E-value: 6.48e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 50312664    48 CQDCKTDNkvkdkaeeeteekpSVWLCLKCGHQGCGRnSQEQHALKHYLTPRsepHCLVLSLDNWSVWCYVCDNEV 123
Cdd:pfam02148   1 CSLCGNTS--------------NLWLCLTCGHVGCGR-YQNSHALEHYEETG---HPLAVNLSTLTVYCYPCDDYV 58
Peptidase_C19E cd02661
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 196-397 4.21e-19

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239126 [Multi-domain]  Cd Length: 304  Bit Score: 88.87  E-value: 4.21e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 196 GLSNLGNTCFFNAVMQNLSQTPVLRELLkevkmsgtivkieppdlaLTEPLEINLEPPGPLTL-AMSQFLNEMQETKKGV 274
Cdd:cd02661   3 GLQNLGNTCFLNSVLQCLTHTPPLANYL------------------LSREHSKDCCNEGFCMMcALEAHVERALASSGPG 64

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 275 VTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRaeehqrvsKGILKAFGNStEKLDEELKnkvkdyekkksMPSFV 354
Cdd:cd02661  65 SAPRIFSSNLKQISKHFRIGRQEDAHEFLRYLLDAMQ--------KACLDRFKKL-KAVDPSSQ-----------ETTLV 124

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 50312664 355 DRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKS 397
Cdd:cd02661 125 QQIFGGYLRSQVKCLNCKHVSNTYDPFLDLSLDIKGADSLEDA 167
Peptidase_C19L cd02668
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 631-804 4.55e-16

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239133 [Multi-domain]  Cd Length: 324  Bit Score: 80.16  E-value: 4.55e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 631 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQcngpkanikgerkhvytNAKKQMLISLAPPVLTLHLKRF---QQAGfNLR 707
Cdd:cd02668 157 TLEECIDEFLKEEQLTGDNQYFCESCNSKT-----------------DATRRIRLTTLPPTLNFQLLRFvfdRKTG-AKK 218

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 708 KVNKHIKFPEILDLAPFCTLKcknvaEENTRVlYSLYGVVEHSGT-MRSGHYTAyakartansHLSNlvlhgdipqdfem 786
Cdd:cd02668 219 KLNASISFPEILDMGEYLAES-----DEGSYV-YELSGVLIHQGVsAYSGHYIA---------HIKD------------- 270

                       170
                ....*....|....*...
gi 50312664 787 ESKGQWFHISDTHVQAVP 804
Cdd:cd02668 271 EQTGEWYKFNDEDVEEMP 288
Peptidase_C19H cd02664
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 630-819 9.83e-16

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239129 [Multi-domain]  Cd Length: 327  Bit Score: 79.07  E-value: 9.83e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 630 CSIQHCLYQFTRNEKLRDANKLLCEVCTRRQcngpkanikgerkhvytNAKKQMLISLAPPVLTLHLKRFQ--QAGFNLR 707
Cdd:cd02664 134 PSVQDLLNYFLSPEKLTGDNQYYCEKCASLQ-----------------DAEKEMKVTGAPEYLILTLLRFSydQKTHVRE 196

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 708 KVNKHIKFPEILDL-----------APFCTLKCKNVAEE--NTRVLYSLYGVVEHSGT-MRSGHYTAYakARTANSHLSN 773
Cdd:cd02664 197 KIMDNVSINEVLSLpvrveskssesPLEKKEEESGDDGElvTRQVHYRLYAVVVHSGYsSESGHYFTY--ARDQTDADST 274

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 50312664 774 LVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTKVLNSQ-------AYLLFYE 819
Cdd:cd02664 275 GQECPEPKDAEENDESKNWYLFNDSRVTFSSFESVQNVTsrfpkdtPYILFYE 327
Peptidase_C19G cd02663
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 629-819 1.18e-15

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239128 [Multi-domain]  Cd Length: 300  Bit Score: 78.51  E-value: 1.18e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 629 ECSIQHCLYQFTRNEKLRDANKLLCEVCTRRQcngpkanikgerkhvytNAKKQMLISLAPPVLTLHLKRFQQAGfnlrK 708
Cdd:cd02663 146 NTSITSCLRQFSATETLCGRNKFYCDECCSLQ-----------------EAEKRMKIKKLPKILALHLKRFKYDE----Q 204

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 709 VNKHIK------FPeiLDLAPFCTlkcKNVAEENTRvLYSLYGVVEH--SGTMRsGHYTAYAKartanshlsnlvlhgdi 780
Cdd:cd02663 205 LNRYIKlfyrvvFP--LELRLFNT---TDDAENPDR-LYELVAVVVHigGGPNH-GHYVSIVK----------------- 260

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 50312664 781 pqdfemeSKGQWFHISDTHVQAVPTTKVLN--------SQAYLLFYE 819
Cdd:cd02663 261 -------SHGGWLLFDDETVEKIDENAVEEffgdspnqATAYVLFYQ 300
Peptidase_C19O cd02671
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 638-763 1.26e-15

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239136 [Multi-domain]  Cd Length: 332  Bit Score: 78.78  E-value: 1.26e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 638 QFTRNEKLRDANKLLCEVCtrrqcngpkanikgerkHVYTNAKKQMLISLAPPVLTLHLKRFQQAGF------NLRKVNK 711
Cdd:cd02671 188 QFASVERIVGEDKYFCENC-----------------HHYTEAERSLLFDKLPEVITIHLKCFAANGSefdcygGLSKVNT 250

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 50312664 712 HIkfpeildLAPFcTLKCKNVAEENTRVLYSLYGVVEHSG-TMRSGHYTAYAK 763
Cdd:cd02671 251 PL-------LTPL-KLSLEEWSTKPKNDVYRLFAVVMHSGaTISSGHYTAYVR 295
Peptidase_C19A cd02657
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 196-427 1.99e-15

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239122 [Multi-domain]  Cd Length: 305  Bit Score: 77.76  E-value: 1.99e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 196 GLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVkieppdlaltepleinLEPPGPLTLAMSQFLNEMQETKKGvV 275
Cdd:cd02657   1 GLTNLGNTCYLNSTLQCLRSVPELRDALKNYNPARRGA----------------NQSSDNLTNALRDLFDTMDKKQEP-V 63

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 276 TPKELFSQVCKKAVRFK------GYQQQDSQELLRYLLDGMRAEehqrvskgilkafgnstekldeelknkvkdYEKKKS 349
Cdd:cd02657  64 PPIEFLQLLRMAFPQFAekqnqgGYAQQDAEECWSQLLSVLSQK------------------------------LPGAGS 113

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 350 MPSFVDRIFGGELTSMIMCDQCRTVSLVH-ESFLDLSLPVlddqSGKKSVN--DKNLKKTVEDEDQDSEEEKDNDS-YIK 425
Cdd:cd02657 114 KGSFIDQLFGIELETKMKCTESPDEEEVStESEYKLQCHI----SITTEVNylQDGLKKGLEEEIEKHSPTLGRDAiYTK 189


                ..
gi 50312664 426 ER 427
Cdd:cd02657 190 TS 191
Peptidase_C19D cd02660
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 195-397 2.05e-14

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239125 [Multi-domain]  Cd Length: 328  Bit Score: 75.10  E-value: 2.05e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 195 KGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLaltepleinleppgpLTLAMSQFLNEMQET-KKG 273
Cdd:cd02660   1 RGLINLGATCFMNVILQALLHNPLLRNYFLSDRHSCTCLSCSPNSC---------------LSCAMDEIFQEFYYSgDRS 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 274 VVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDgmraeehqrvskgilkafgnsteKLDEELKNKVKDYEKKKSMPSF 353
Cdd:cd02660  66 PYGPINLLYLSWKHSRNLAGYSQQDAHEFFQFLLD-----------------------QLHTHYGGDKNEANDESHCNCI 122

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 50312664 354 VDRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPvLDDQSGKKS 397
Cdd:cd02660 123 IHQTFSGSLQSSVTCQRCGGVSTTVDPFLDLSLD-IPNKSTPSW 165
Peptidase_C19 cd02257
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ...
 196-400 6.49e-14

Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239072 [Multi-domain]  Cd Length: 255  Bit Score: 72.52  E-value: 6.49e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 196 GLSNLGNTCFFNAVMQNLSqtpvlrellkevkmsgtivkieppdlaltepleinleppgpltlamsqflnemqetkkgvv 275
Cdd:cd02257   1 GLNNLGNTCYLNSVLQALF------------------------------------------------------------- 19

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 276 tpkelfsqvckkavrfkgYQQQDSQELLRYLLDgmraeehqrvskgilkafgnsteKLDEELKNKVKDYEKKKSMPSFVD 355
Cdd:cd02257  20 ------------------SEQQDAHEFLLFLLD-----------------------KLHEELKKSSKRTSDSSSLKSLIH 58

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 50312664 356 RIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSVND 400
Cdd:cd02257  59 DLFGGKLESTIVCLECGHESVSTEPELFLSLPLPVKGLPQVSLED 103
Peptidase_C19G cd02663
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 196-388 7.62e-12

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239128 [Multi-domain]  Cd Length: 300  Bit Score: 66.95  E-value: 7.62e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 196 GLSNLGNTCFFNAVMQNLSQTPVLrELLKevkmsgtivkieppDLaltepleinleppgpltlaMSQFLNemQETKKGVV 275
Cdd:cd02663   1 GLENFGNTCYCNSVLQALYFENLL-TCLK--------------DL-------------------FESISE--QKKRTGVI 44

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 276 TPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDgmraeehqRVSKGILKafgnstEKLDEELKNKVKDYEKKKSMPSFVD 355
Cdd:cd02663  45 SPKKFITRLKRENELFDNYMHQDAHEFLNFLLN--------EIAEILDA------ERKAEKANRKLNNNNNAEPQPTWVH 110

                       170       180       190
                ....*....|....*....|....*....|...
gi 50312664 356 RIFGGELTSMIMCDQCRTVSLVHESFLDLSLPV 388
Cdd:cd02663 111 EIFQGILTNETRCLTCETVSSRDETFLDLSIDV 143
COG5077 COG5077
Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, ...
 673-809 8.76e-12

Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227409 [Multi-domain]  Cd Length: 1089  Bit Score: 69.13  E-value: 8.76e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664  673 KHVYTNAKKQMLISLAPPVLTLHLKRFQqAGF---NLRKVNKHIKFPEILDLAPFCTLKCKNvaEENTRVLYSLYGVVEH 749
Cdd:COG5077  363 KHGLQDAKKGVIFESLPPVLHLQLKRFE-YDFerdMMVKINDRYEFPLEIDLLPFLDRDADK--SENSDAVYVLYGVLVH 439

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664  750 SGTMRSGHYTAYAKArtanshlsnlvlhgdipqdfemESKGQWFHISDTHVQAVPTTKVL 809
Cdd:COG5077  440 SGDLHEGHYYALLKP----------------------EKDGRWYKFDDTRVTRATEKEVL 477
peptidase_C19C cd02659
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 196-393 2.45e-11

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239124 [Multi-domain]  Cd Length: 334  Bit Score: 65.74  E-value: 2.45e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 196 GLSNLGNTCFFNAVMQNLSQTPVLRELLkevkmsgtivkieppdlaLTEPLEINLEPPGPLTLAM-SQFLnEMQETKKGV 274
Cdd:cd02659   4 GLKNQGATCYMNSLLQQLYMTPEFRNAV------------------YSIPPTEDDDDNKSVPLALqRLFL-FLQLSESPV 64

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 275 VTPKelfsqVCKKAVRFKG-----YQQQDSQELLRYLLDgmraeehqrvskgilkafgnsteKLDEELknkvkdyeKKKS 349
Cdd:cd02659  65 KTTE-----LTDKTRSFGWdslntFEQHDVQEFFRVLFD-----------------------KLEEKL--------KGTG 108

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 50312664 350 MPSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQS 393
Cdd:cd02659 109 QEGLIKNLFGGKLVNYIICKECPHESEREEYFLDLQVAVKGKKN 152
Peptidase_C19A cd02657
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 665-819 1.74e-10

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239122 [Multi-domain]  Cd Length: 305  Bit Score: 63.12  E-value: 1.74e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 665 KANIKGERKHVYTnakKQMLISLAPPVLTLHLKRFQ---QAGFNLrKVNKHIKFPEILDLAPFCTLKCknvaeentrvLY 741
Cdd:cd02657 176 KHSPTLGRDAIYT---KTSRISRLPKYLTVQFVRFFwkrDIQKKA-KILRKVKFPFELDLYELCTPSG----------YY 241

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 742 SLYGVVEHSG-TMRSGHYTAYAKArtanshlsnlvlhgdipqdfemESKGQWFHISDTHVQAVPTTKVLN-------SQA 813
Cdd:cd02657 242 ELVAVITHQGrSADSGHYVAWVRR----------------------KNDGKWIKFDDDKVSEVTEEDILKlsgggdwHIA 299


                ....*.
gi 50312664 814 YLLFYE 819
Cdd:cd02657 300 YILLYK 305
COG5533 COG5533
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
671-821 4.95e-10

Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444284 [Multi-domain]  Cd Length: 284  Bit Score: 61.36  E-value: 4.95e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 671 ERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNlRKVNKHIKfpEILDLaPFCTLKCKNVaEENTRvlYSLYGVVEHS 750
Cdd:COG5533 162 EELEVQAKQEYEVSFVKLPKILTIQLKRFANLGGN-QKIDTEVD--EKFEL-PVKHDQILNI-VKETY--YDLVGFVLHQ 234

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 50312664 751 GTMRSGHYTAYAKartanshlsnlvlhgdipqdfemeSKGQWFHISDTHVQAVPTTKVLNS---QAYLLFYERI 821
Cdd:COG5533 235 GSLEGGHYIAYVK------------------------KGGKWEKANDSDVTPVSEEEAINEkakNAYLYFYERI 284
ZnF_UBP smart00290
Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger;
47-114 2.62e-08

Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger;


Pssm-ID: 197632  Cd Length: 50  Bit Score: 50.83  E-value: 2.62e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 50312664     47 ICQDCKTDNKVkdkaeeeteekpsvWLCLKCGHQGCGRnSQEQHALKHYltpRSEPHCLVLSLDNWSV 114
Cdd:smart00290   1 RCSVCGTIENL--------------WLCLTCGQVGCGR-YQNGHALEHF---EETGHPLVVKLGTQRV 50
Peptidase_C19O cd02671
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 196-395 4.38e-08

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239136 [Multi-domain]  Cd Length: 332  Bit Score: 55.67  E-value: 4.38e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 196 GLSNLGNTCFFNAVMQNLSQTPVLRELLKEvkMSGTIVKIEppdlALTEPLEINLEppgpltLAMSQFLNEMqetkkgvv 275
Cdd:cd02671  26 GLNNLGNTCYLNSVLQVLYFCPGFKHGLKH--LVSLISSVE----QLQSSFLLNPE------KYNDELANQA-------- 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 276 tPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRaeehqrvskgilkafgnstekldeelknkvkdyekkksmpSFVD 355
Cdd:cd02671  86 -PRRLLNALREVNPMYEGYLQHDAQEVLQCILGNIQ----------------------------------------ELVE 124

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 50312664 356 RIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGK 395
Cdd:cd02671 125 KDFQGQLVLRTRCLECETFTERREDFQDISVPVQESELSK 164
Peptidase_C19L cd02668
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 196-400 4.70e-08

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239133 [Multi-domain]  Cd Length: 324  Bit Score: 55.50  E-value: 4.70e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 196 GLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTEPLEINLEppgpLTLAMSQflneMQETKKGVV 275
Cdd:cd02668   1 GLKNLGATCYVNSFLQLWFMNLEFRKAVYECNSTEDAELKNMPPDKPHEPQTIIDQ----LQLIFAQ----LQFGNRSVV 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 276 TPKELFsqvckKAVRFKGYQQQDSQELLRYLLDGMRAeehqrvskgilkafgnsteKLDEELKNKVKdyekkksmpSFVD 355
Cdd:cd02668  73 DPSGFV-----KALGLDTGQQQDAQEFSKLFLSLLEA-------------------KLSKSKNPDLK---------NIVQ 119

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 50312664 356 RIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSVND 400
Cdd:cd02668 120 DLFRGEYSYVTQCSKCGRESSLPSKFYELELQLKGHKTLEECIDE 164
Peptidase_C19R cd02674
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 196-388 9.08e-07

A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239139 [Multi-domain]  Cd Length: 230  Bit Score: 50.75  E-value: 9.08e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 196 GLSNLGNTCFFNAVMQNLSQtpvlrellkevkmsgtivkieppdlaltepleinleppgpltlamsqflnemqetkkgvv 275
Cdd:cd02674   1 GLRNLGNTCYMNSILQCLSA------------------------------------------------------------ 20

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 276 tpkelfsqvckkavrfkgyQQQDSQELLRYLLDGMRaeehqrvskgilkafgnstekldeelknkvkdyekkksmpSFVD 355
Cdd:cd02674  21 -------------------DQQDAQEFLLFLLDGLH----------------------------------------SIIV 41

                       170       180       190
                ....*....|....*....|....*....|...
gi 50312664 356 RIFGGELTSMIMCDQCRTVSLVHESFLDLSLPV 388
Cdd:cd02674  42 DLFQGQLKSRLTCLTCGKTSTTFEPFTYLSLPI 74
Peptidase_C19B cd02658
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 676-819 1.34e-06

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239123 [Multi-domain]  Cd Length: 311  Bit Score: 51.17  E-value: 1.34e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 676 YTNAKKQMLISLAPPVLTLHLKRFQ-QAGFNLRKVNKHIKFPEILDLAPfctlkcknvaeentrvlYSLYGVVEHSGT-M 753
Cdd:cd02658 203 KTTATKTTGFKTFPDYLVINMKRFQlLENWVPKKLDVPIDVPEELGPGK-----------------YELIAFISHKGTsV 265

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 50312664 754 RSGHYTAYAKARTANshlsnlvlhgdipqdfemesKGQWFHISDTHVQAVPTTKVLNSQAYLLFYE 819
Cdd:cd02658 266 HSGHYVAHIKKEIDG--------------------EGKWVLFNDEKVVASQDPPEMKKLGYIYFYQ 311
Peptidase_C19M cd02669
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 670-819 5.36e-05

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239134 [Multi-domain]  Cd Length: 440  Bit Score: 46.54  E-value: 5.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 670 GERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNLRKvNKHI-KFP-EILDLAPFCTlkcKNVAEENTRVLYSLYGVV 747
Cdd:cd02669 314 GKTETELKDSLKRYLISRLPKYLIFHIKRFSKNNFFKEK-NPTIvNFPiKNLDLSDYVH---FDKPSLNLSTKYNLVANI 389

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 50312664 748 EHSGT-MRSGHYTAYakartanshlsnlVLHgdipqdfemESKGQWFHISDTHVQAVPTTKVLNSQAYLLFYE 819
Cdd:cd02669 390 VHEGTpQEDGTWRVQ-------------LRH---------KSTNKWFEIQDLNVKEVLPQLIFLSESYIQIWE 440
Peptidase_C19N cd02670
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 685-763 8.27e-05

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239135 [Multi-domain]  Cd Length: 241  Bit Score: 44.83  E-value: 8.27e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50312664 685 ISLAPPVLTLHLKRFQQAGFNLRKVNKHIKFPEILDLAPF----------CTLKCKNVAEEN----TRVLY--SLYGVVE 748
Cdd:cd02670  95 FAKAPSCLIICLKRYGKTEGKAQKMFKKILIPDEIDIPDFvaddpracskCQLECRVCYDDKdfspTCGKFklSLCSAVC 174

                        90
                ....*....|....*.
gi 50312664 749 HSGTMR-SGHYTAYAK 763
Cdd:cd02670 175 HRGTSLeTGHYVAFVR 190
Peptidase_C19F cd02662
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 196-227 2.51e-04

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239127 [Multi-domain]  Cd Length: 240  Bit Score: 43.51  E-value: 2.51e-04
                        10        20        30
                ....*....|....*....|....*....|..
gi 50312664 196 GLSNLGNTCFFNAVMQNLSQTPVLRELLKEVK 227
Cdd:cd02662   1 GLVNLGNTCFMNSVLQALASLPSLIEYLEEFL 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH