NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|48762704|ref|NP_001001653|]
View 

mediator of RNA polymerase II transcription subunit 8 isoform 1 [Homo sapiens]

Protein Classification

Med8 domain-containing protein( domain architecture ID 10562974)

Med8 domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Med8 pfam10232
Mediator of RNA polymerase II transcription complex subunit 8; Arc32, or Med8, is one of the ...
 1-176 2.55e-59

Mediator of RNA polymerase II transcription complex subunit 8; Arc32, or Med8, is one of the subunits of the Mediator complex of RNA polymerase II. The region conserved contains two alpha helices putatively necessary for binding to other subunits within the core of the Mediator complex. The N-terminus of Med8 binds to the essential core Head part of Mediator and the C-terminus hinges to Med18 on the non-essential part of the Head that also includes Med20.


:

Pssm-ID: 463012  Cd Length: 230  Bit Score: 184.47  E-value: 2.55e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762704     1 MRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISK--EERESESGGLR 78
Cdd:pfam10232  90 ARLTEGRVPVFSHDVVPDLLRTKLDPEVEPREAQLEARARNLGGEYTQKQIAGVNKVVTGLRRKLSKarEEWEEEEGSRG 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762704    79 PNKQTFNPTDTNALVAAVAFGKGLSNWRPSGSSGPGQAGQpgagtilagtsglqqvqmagapsqqqpmlsgvqmaqaGQP 158
Cdd:pfam10232 170 GIQQTSSGADTEALVAAVGFGKGLKPGVEFGISGPPPSGG-------------------------------------GMM 212

                         170
                  ....*....|....*...
gi 48762704   159 GKMPSGIKTNIKSASMHP 176
Cdd:pfam10232 213 GKLPSGIKTNIKGAQIHP 230
 
Name Accession Description Interval E-value
Med8 pfam10232
Mediator of RNA polymerase II transcription complex subunit 8; Arc32, or Med8, is one of the ...
 1-176 2.55e-59

Mediator of RNA polymerase II transcription complex subunit 8; Arc32, or Med8, is one of the subunits of the Mediator complex of RNA polymerase II. The region conserved contains two alpha helices putatively necessary for binding to other subunits within the core of the Mediator complex. The N-terminus of Med8 binds to the essential core Head part of Mediator and the C-terminus hinges to Med18 on the non-essential part of the Head that also includes Med20.


Pssm-ID: 463012  Cd Length: 230  Bit Score: 184.47  E-value: 2.55e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762704     1 MRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISK--EERESESGGLR 78
Cdd:pfam10232  90 ARLTEGRVPVFSHDVVPDLLRTKLDPEVEPREAQLEARARNLGGEYTQKQIAGVNKVVTGLRRKLSKarEEWEEEEGSRG 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762704    79 PNKQTFNPTDTNALVAAVAFGKGLSNWRPSGSSGPGQAGQpgagtilagtsglqqvqmagapsqqqpmlsgvqmaqaGQP 158
Cdd:pfam10232 170 GIQQTSSGADTEALVAAVGFGKGLKPGVEFGISGPPPSGG-------------------------------------GMM 212

                         170
                  ....*....|....*...
gi 48762704   159 GKMPSGIKTNIKSASMHP 176
Cdd:pfam10232 213 GKLPSGIKTNIKGAQIHP 230
 
Name Accession Description Interval E-value
Med8 pfam10232
Mediator of RNA polymerase II transcription complex subunit 8; Arc32, or Med8, is one of the ...
 1-176 2.55e-59

Mediator of RNA polymerase II transcription complex subunit 8; Arc32, or Med8, is one of the subunits of the Mediator complex of RNA polymerase II. The region conserved contains two alpha helices putatively necessary for binding to other subunits within the core of the Mediator complex. The N-terminus of Med8 binds to the essential core Head part of Mediator and the C-terminus hinges to Med18 on the non-essential part of the Head that also includes Med20.


Pssm-ID: 463012  Cd Length: 230  Bit Score: 184.47  E-value: 2.55e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762704     1 MRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISK--EERESESGGLR 78
Cdd:pfam10232  90 ARLTEGRVPVFSHDVVPDLLRTKLDPEVEPREAQLEARARNLGGEYTQKQIAGVNKVVTGLRRKLSKarEEWEEEEGSRG 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762704    79 PNKQTFNPTDTNALVAAVAFGKGLSNWRPSGSSGPGQAGQpgagtilagtsglqqvqmagapsqqqpmlsgvqmaqaGQP 158
Cdd:pfam10232 170 GIQQTSSGADTEALVAAVGFGKGLKPGVEFGISGPPPSGG-------------------------------------GMM 212

                         170
                  ....*....|....*...
gi 48762704   159 GKMPSGIKTNIKSASMHP 176
Cdd:pfam10232 213 GKLPSGIKTNIKGAQIHP 230
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH