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Conserved domains on  [gi|48527957|ref|NP_001001556|]
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N-acetylgalactosamine kinase isoform 2 [Homo sapiens]

Protein Classification

galactokinase family protein( domain architecture ID 1004942)

galactokinase family protein such as galactokinase that catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

CATH:  1.20.1440.340|3.30.230.10|3.30.70.3170
EC:  2.7.1.-
Gene Ontology:  GO:0005524|GO:0004335|GO:0005975
PubMed:  26862196|15526155

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN02521 super family cl33510
galactokinase
 7-444 2.15e-161

galactokinase


The actual alignment was detected with superfamily member PLN02521:

Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 464.57  E-value: 2.15e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957    7 RLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTY-ALQLANTNPLYPDFSTSAN 85
Cdd:PLN02521  31 RYARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSkKLRIANVNDKYTTCTFPAD 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957   86 NIQ-IDKTKPLWHNYFLCGLKGIQEHFGLSN-----LTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVE 159
Cdd:PLN02521 111 PDQeVDLANHKWGNYFICGYKGVFEFLKSKGvdvgpPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKKE 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  160 LAEICAKSERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEMNKAATSH--FNIRVMECR 237
Cdd:PLN02521 191 VAQFTCKCERHIGTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAAtnYNNRVVECR 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  238 LAAKLLA-KYKSLQWD---KVLRLEEVQaKLGISLEE------MLLVTEDALHPEPYNPEEICRCLGISLEELRTQilSP 307
Cdd:PLN02521 271 LAAIVLAvKLGMSAEEaisKVKTLSDVE-GLCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLTSIFKN--SP 347

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  308 NTQDVLI----FKLYQRAKHVYSEAARVLQFKKICEE--APENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF 381
Cdd:PLN02521 348 TSLAVLKaakhFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRDN 427

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 48527957  382 GAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKAYYQ-RSD-GSLAPEKQSL--FATKPGGGALVL 444
Cdd:PLN02521 428 GALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFYKsRIEkGVIKEEDLGLyvFASKPSSGAAIL 494
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 7-444 2.15e-161

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 464.57  E-value: 2.15e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957    7 RLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTY-ALQLANTNPLYPDFSTSAN 85
Cdd:PLN02521  31 RYARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSkKLRIANVNDKYTTCTFPAD 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957   86 NIQ-IDKTKPLWHNYFLCGLKGIQEHFGLSN-----LTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVE 159
Cdd:PLN02521 111 PDQeVDLANHKWGNYFICGYKGVFEFLKSKGvdvgpPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKKE 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  160 LAEICAKSERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEMNKAATSH--FNIRVMECR 237
Cdd:PLN02521 191 VAQFTCKCERHIGTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAAtnYNNRVVECR 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  238 LAAKLLA-KYKSLQWD---KVLRLEEVQaKLGISLEE------MLLVTEDALHPEPYNPEEICRCLGISLEELRTQilSP 307
Cdd:PLN02521 271 LAAIVLAvKLGMSAEEaisKVKTLSDVE-GLCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLTSIFKN--SP 347

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  308 NTQDVLI----FKLYQRAKHVYSEAARVLQFKKICEE--APENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF 381
Cdd:PLN02521 348 TSLAVLKaakhFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRDN 427

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 48527957  382 GAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKAYYQ-RSD-GSLAPEKQSL--FATKPGGGALVL 444
Cdd:PLN02521 428 GALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFYKsRIEkGVIKEEDLGLyvFASKPSSGAAIL 494
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
7-444 2.80e-88

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 273.57  E-value: 2.80e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957   7 RLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTYALQLANTNplYPD-FSTSAN 85
Cdd:COG0153   1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSAD--FDEeVEFDLD 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  86 NIQIDKTKPlWHNYFLcG-LKGIQEHfGLsNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEIC 164
Cdd:COG0153  79 DLEPGEEDG-WANYVR-GvAWALQER-GY-KLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIG 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957 165 AKSE-RYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLP-SGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKL 242
Cdd:COG0153 155 QRAEnEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPlEGYALVIVDTNVKHS-LADSEYNERRAECEAAAAI 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957 243 LAKykslqwdKVLRleEVqaklgiSLEEmllvtedalhpepynpeeicrclgisLEELRTQILSPntqdvlifKLYQRAK 322
Cdd:COG0153 234 LGV-------KSLR--DV------TLED--------------------------LEAARARLGDE--------VLRRRAR 264

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957 323 HVYSEAARVLQFKKICEeapENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGGCTVSMV 401
Cdd:COG0153 265 HVVTENQRVLEAVEALR---AGDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALAEaGVLGARMTGGGFGGCTIALV 341

                       410       420       430       440
                ....*....|....*....|....*....|....*....|...
gi 48527957 402 PADKLPSFLANVHKAYYQRsdGSLAPEkqsLFATKPGGGALVL 444
Cdd:COG0153 342 PKDAVDEFIEAVAEAYAEK--TGLEPD---FYVVKPSDGARRL 379
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 9-442 2.74e-79

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 250.90  E-value: 2.74e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957     9 LKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPV--KTYALQLANTNPLYPDFSTsanN 86
Cdd:TIGR00131   2 ESIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRddKNVRIYLANADNKFAERSL---D 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957    87 IQIDKTKPL-WHNYFLCGLKGIQEHFGLSNLtGMNCLVDGNIPPSSGLSSSSALVCCAGlVTLTVLGRN--LSKVELAEI 163
Cdd:TIGR00131  79 LPLDGSEVSdWANYFKGVLHVAQERFNSFPL-GADIVCSGNVPTGSGLSSSAAFECAVG-AVLQNMGHLplDSKQILLRI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957   164 CAKSERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLP-SGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKL 242
Cdd:TIGR00131 157 QVAENHFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPqLGIAFVIANTNVKRT-LAPSNYNTRRQECTTAANF 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957   243 LAKykslqwdkvlrleevqaKLGISLEEMLlvtedalhPEPYNPeeicrclgislEELRTQILSPNTQdvlifklyQRAK 322
Cdd:TIGR00131 236 LAA-----------------TDKGALRDFM--------NEYFAR-----------YIARLTKMLPLVE--------ERAK 271

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957   323 HVYSEAARVLQFKKICEEapENMVQlLGELMNQSHMSCRDMYECSCPELDQLVDICR-KFGAQGSRLTGAGWGGCTVSMV 401
Cdd:TIGR00131 272 HVVSENLRVLKAVKAMKD--NDFKQ-FGALMNESHASCDDDYECTCPEIDELVCSAAlVNGSGGSRMTGAGFGGCTVHLV 348

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 48527957   402 PADKLPSFLANVHKAYYQRSDgslAPEKQSLFATKPGGGAL 442
Cdd:TIGR00131 349 PNENVDKVRQAVADKYPKKTG---LELTFYVIVSKPGAGSC 386
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 15-62 1.25e-21

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 87.51  E-value: 1.25e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 48527957    15 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEP 62
Cdd:pfam10509   3 FEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 7-444 2.15e-161

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 464.57  E-value: 2.15e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957    7 RLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTY-ALQLANTNPLYPDFSTSAN 85
Cdd:PLN02521  31 RYARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSkKLRIANVNDKYTTCTFPAD 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957   86 NIQ-IDKTKPLWHNYFLCGLKGIQEHFGLSN-----LTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVE 159
Cdd:PLN02521 111 PDQeVDLANHKWGNYFICGYKGVFEFLKSKGvdvgpPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKKE 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  160 LAEICAKSERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEMNKAATSH--FNIRVMECR 237
Cdd:PLN02521 191 VAQFTCKCERHIGTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAAtnYNNRVVECR 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  238 LAAKLLA-KYKSLQWD---KVLRLEEVQaKLGISLEE------MLLVTEDALHPEPYNPEEICRCLGISLEELRTQilSP 307
Cdd:PLN02521 271 LAAIVLAvKLGMSAEEaisKVKTLSDVE-GLCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLTSIFKN--SP 347

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  308 NTQDVLI----FKLYQRAKHVYSEAARVLQFKKICEE--APENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF 381
Cdd:PLN02521 348 TSLAVLKaakhFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRDN 427

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 48527957  382 GAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKAYYQ-RSD-GSLAPEKQSL--FATKPGGGALVL 444
Cdd:PLN02521 428 GALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFYKsRIEkGVIKEEDLGLyvFASKPSSGAAIL 494
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
7-444 2.80e-88

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 273.57  E-value: 2.80e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957   7 RLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTYALQLANTNplYPD-FSTSAN 85
Cdd:COG0153   1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSAD--FDEeVEFDLD 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  86 NIQIDKTKPlWHNYFLcG-LKGIQEHfGLsNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEIC 164
Cdd:COG0153  79 DLEPGEEDG-WANYVR-GvAWALQER-GY-KLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIG 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957 165 AKSE-RYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLP-SGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKL 242
Cdd:COG0153 155 QRAEnEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPlEGYALVIVDTNVKHS-LADSEYNERRAECEAAAAI 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957 243 LAKykslqwdKVLRleEVqaklgiSLEEmllvtedalhpepynpeeicrclgisLEELRTQILSPntqdvlifKLYQRAK 322
Cdd:COG0153 234 LGV-------KSLR--DV------TLED--------------------------LEAARARLGDE--------VLRRRAR 264

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957 323 HVYSEAARVLQFKKICEeapENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGGCTVSMV 401
Cdd:COG0153 265 HVVTENQRVLEAVEALR---AGDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALAEaGVLGARMTGGGFGGCTIALV 341

                       410       420       430       440
                ....*....|....*....|....*....|....*....|...
gi 48527957 402 PADKLPSFLANVHKAYYQRsdGSLAPEkqsLFATKPGGGALVL 444
Cdd:COG0153 342 PKDAVDEFIEAVAEAYAEK--TGLEPD---FYVVKPSDGARRL 379
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 9-442 2.74e-79

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 250.90  E-value: 2.74e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957     9 LKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPV--KTYALQLANTNPLYPDFSTsanN 86
Cdd:TIGR00131   2 ESIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRddKNVRIYLANADNKFAERSL---D 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957    87 IQIDKTKPL-WHNYFLCGLKGIQEHFGLSNLtGMNCLVDGNIPPSSGLSSSSALVCCAGlVTLTVLGRN--LSKVELAEI 163
Cdd:TIGR00131  79 LPLDGSEVSdWANYFKGVLHVAQERFNSFPL-GADIVCSGNVPTGSGLSSSAAFECAVG-AVLQNMGHLplDSKQILLRI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957   164 CAKSERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLP-SGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKL 242
Cdd:TIGR00131 157 QVAENHFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPqLGIAFVIANTNVKRT-LAPSNYNTRRQECTTAANF 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957   243 LAKykslqwdkvlrleevqaKLGISLEEMLlvtedalhPEPYNPeeicrclgislEELRTQILSPNTQdvlifklyQRAK 322
Cdd:TIGR00131 236 LAA-----------------TDKGALRDFM--------NEYFAR-----------YIARLTKMLPLVE--------ERAK 271

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957   323 HVYSEAARVLQFKKICEEapENMVQlLGELMNQSHMSCRDMYECSCPELDQLVDICR-KFGAQGSRLTGAGWGGCTVSMV 401
Cdd:TIGR00131 272 HVVSENLRVLKAVKAMKD--NDFKQ-FGALMNESHASCDDDYECTCPEIDELVCSAAlVNGSGGSRMTGAGFGGCTVHLV 348

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 48527957   402 PADKLPSFLANVHKAYYQRSDgslAPEKQSLFATKPGGGAL 442
Cdd:TIGR00131 349 PNENVDKVRQAVADKYPKKTG---LELTFYVIVSKPGAGSC 386
PRK05322 PRK05322
galactokinase; Provisional
 10-417 6.14e-51

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 176.59  E-value: 6.14e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957   10 KLKEMFNSKFGSIPK--FYvrAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTYALQLANTNplYPD---FSTSA 84
Cdd:PRK05322   5 ELKKKFAEVFGEEAEdvFF--SPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSAN--FEDlgiIEFDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957   85 NNIQIDKtKPLWHNYFLCGLKGIQEHfGLSNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEIC 164
Cdd:PRK05322  81 DDLSFDK-EDDWANYPKGVLKFLQEA-GYKIDHGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRLELVKLG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  165 AKSE-RYIGTEGGGMDQSISFLAEEGTAKLI-------EFSPLRATDVKLpsgavfVIANScvemNKA---ATSHFNIRV 233
Cdd:PRK05322 159 QKTEnEFIGVNSGIMDQFAIGMGKKDHAILLdcntleyEYVPLDLGDYVI------VIMNT----NKRrelADSKYNERR 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  234 MECRLAakllakykslqwdkvlrLEEVQAKLGI-SLEEmllVTEDAlhpepynpeeicrclgisLEELRTQILSPNtqdv 312
Cdd:PRK05322 229 AECEKA-----------------LEELQKKLDIkSLGE---LTEEE------------------FDEYSYLIKDET---- 266

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  313 lifkLYQRAKHVYSEAARVLQFKKICEeapENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGA 391
Cdd:PRK05322 267 ----LLKRARHAVTENQRTLKAVKALK---AGDLEKFGRLMNASHVSLRDDYEVTGLELDTLVEAAWKQeGVLGARMTGA 339

                        410       420
                 ....*....|....*....|....*.
gi 48527957  392 GWGGCTVSMVPADKLPSFLANVHKAY 417
Cdd:PRK05322 340 GFGGCAIAIVKKDKVEAFKENVGKAY 365
PRK05101 PRK05101
galactokinase; Provisional
 10-421 1.60e-50

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 175.50  E-value: 1.60e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957   10 KLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEP-----VKTYALQLANtnpLYPDFSTSA 84
Cdd:PRK05101   6 KTQSLFAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKrddriVRVIAADYDN---QQDEFSLDA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957   85 nNIQIDKTKpLWHNYFLCGLKGIQEHfgLSNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEIC 164
Cdd:PRK05101  83 -PIVPHPEQ-QWANYVRGVVKHLQER--NPDFGGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLYHLPLSGAEIALNG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  165 AKSE-RYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKLL 243
Cdd:PRK05101 159 QEAEnQFVGCNCGIMDQLISALGKKDHALLIDCRSLETKAVPMPEGVAVVIINSNVKRG-LVDSEYNTRRQQCETAARFF 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  244 AKykslqwdKVLR---LEEVQAKlgisleemllvtEDALHPEpynpeeicrclgisleelrtqilspntqdvlifkLYQR 320
Cdd:PRK05101 238 GV-------KALRdvtLEQFNAV------------AAELDPV----------------------------------VAKR 264

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  321 AKHVYSEAARVLQFKKICEEapENMVqLLGELMNQSHMSCRDMYECSCPELDQLVDICR-KFGAQGS-RLTGAGWGGCTV 398
Cdd:PRK05101 265 ARHVITENARTLEAASALAA--GDLK-RMGELMAESHASMRDDFEITVPQIDTLVEIVKaVIGDQGGvRMTGGGFGGCIV 341

                        410       420
                 ....*....|....*....|...
gi 48527957  399 SMVPADKLPSFLANVHKAYYQRS 421
Cdd:PRK05101 342 ALVPEELVEAVRQAVAEQYEAKT 364
PRK03817 PRK03817
galactokinase; Provisional
 27-420 2.49e-42

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 152.84  E-value: 2.49e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957   27 VRAPGRVNIIGEHIDYC-GYsVLPMAVEQDVLIAVEPVKTYAlqlantnpLYPDFSTSANNIQIDKTKPL--WHNYFLCG 103
Cdd:PRK03817   3 VKSPGRVNLIGEHTDYNdGY-VLPFAINLYTFLEIEKSEKFI--------FYSENFNEEKTFELDKLEKLnsWADYIKGV 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  104 LKGIQEHFGlsNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSER-YIGTEGGGMDQSI 182
Cdd:PRK03817  74 IWVLEKRGY--EVGGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLAREAENeFVGVPCGIMDQFA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  183 SFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEmNKAATSHFNIRVMECRLAAKLLAKYKSLQwdkvlrleevqa 262
Cdd:PRK03817 152 VAFGKKDHAIFLDTMTLEYEYVPFPEDYEILVFDTGVK-RELASSEYNERRQECEEALKILGKKSSKE------------ 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  263 klgisleemllVTEDALHpepynpeeicrclgiSLEELrtqilspntqdvlifkLYQRAKHVYSEAARVLQFKKICEeap 342
Cdd:PRK03817 219 -----------VTEEDLS---------------KLPPL----------------LRKRAGYVLRENERVLKVRDALK--- 253

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 48527957  343 ENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKAYYQR 420
Cdd:PRK03817 254 EGDIETLGELLTESHWDLADNYEVSCEELDFFVEFALELGAYGARLTGAGFGGSAIALVDKGKFESIGEELLEEYKKR 331
PRK00555 PRK00555
galactokinase; Provisional
 29-441 2.06e-27

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 112.26  E-value: 2.06e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957   29 APGRVNIIGEHIDY-CGYSvLPMAVEQDVLIAVEPVKTYALQLANtnplypDFSTSANNIQIDkTKPL----WHNYFLCG 103
Cdd:PRK00555   7 APGRINLIGEHTDYnLGFA-LPIALPQRTVVTFTPEHTDAITASS------DRADGSARIPLD-TTPGqvtgWAAYAAGV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  104 LKGIQEHFglSNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSER-YIGTEGGGMDQSI 182
Cdd:PRK00555  79 IWALRGAG--HPVPGGAMSITSDVEIGSGLSSSAALECAVLGAVGAATGTRIDRLEQARLAQRAENeYVGAPTGLLDQLA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  183 SFLAEEGTAKLIEFSPLRATDVKLPSGA--VFVIANSCVEMNKAATSHFNIRVMECRLAAKLLAkykslqwdkVLRLEEV 260
Cdd:PRK00555 157 ALFGAPKTALLIDFRDLTVRPVAFDPDAagVVLLLMDSRARHRHAGGEYAARRASCERAAADLG---------VSSLRAV 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  261 QAKLGISLeemllvtedalhpepynpeeicrclgisleelrTQILSPNTqdvlifklYQRAKHVYSEAARVLQFKKICEE 340
Cdd:PRK00555 228 QDRGLAAL---------------------------------GAIADPID--------ARRARHVLTENQRVLDFAAALAD 266

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  341 APenmVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKAYyqR 420
Cdd:PRK00555 267 SD---FTAAGQLLTASHASMRDDFEITTERIDLIADSAVRAGALGARMTGGGFGGCVIALVPADRAEDVADTVRRAA--V 341

                        410       420
                 ....*....|....*....|.
gi 48527957  421 SDGSLAPekqSLFATKPGGGA 441
Cdd:PRK00555 342 TAGYPEP---AVSRTYAAPGA 359
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 15-62 1.25e-21

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 87.51  E-value: 1.25e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 48527957    15 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEP 62
Cdd:pfam10509   3 FEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
PTZ00290 PTZ00290
galactokinase; Provisional
 29-420 6.98e-17

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 82.56  E-value: 6.98e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957   29 APGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTYA---LQLANTNPLYpdfstsannIQIDKTKPLWHN----YFL 101
Cdd:PTZ00290  42 APGRVNFIGEHVDYMGGYVCPAAVLEGCHILVGRVKHFCdhkLRFATETDEH---------FVLDHLGGAKHNkawtTFV 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  102 CGLKGIQ-EHFGLS----NLTGMNCLVDGNIPPSSGLSSSSAL-VCCAGLVTLTVLGR----------------NLSKVE 159
Cdd:PTZ00290 113 RGAATLRlNRLGVAidapSLQGVCMVVHGTLPMGAGMSASASFgVALLNAINTVVTRRykgcptspgrrysilpPMSKEE 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  160 LAEIcAKSERYIGTEGGG-----MDQSISFLAEEG----------TAKLIEFSPLratdvkLPSGAVFVIANSCVEMNka 224
Cdd:PTZ00290 193 LIEL-AKQARRIETEFCGvnvgiMDQFISAFAEEDkfmfldckslTFESHDMTPL------LGDGACFLLIDSMIKHD-- 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  225 atshfnirvmecrLAAKLLAKYKSLQWDkvlrLEEVQAKLG--ISLEEMLLVTEDALHPEPY----NPEEIcrclgisLE 298
Cdd:PTZ00290 264 -------------LLGGTAGMYNTVRSD----QEGAQKKIGkhRYRGKPFTFSDLVRNPKKYtfdgDVVAF-------ME 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  299 ELRTQiLSPNTqdvlifklYQRAKHVYSEAARVLQFKKICEEA----PENMVQLLGELMNQSHMSCRDMYECSCPELDQL 374
Cdd:PTZ00290 320 SCKPL-MTPGE--------FERGTYNIMEQIRTLEFIKLNDPElplsREERFRKAGEILNAGHQGMRDLMKITTPELDFI 390

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 48527957  375 VD-ICRKFGAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKAYYQR 420
Cdd:PTZ00290 391 HElINEEKGVAGGRMMGGGFGGCIILLLKKNAVDRVVAHVREKFKAR 437
PLN02865 PLN02865
galactokinase
 27-444 8.22e-15

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 75.99  E-value: 8.22e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957   27 VRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTYALQLAnTNPLYPDFSTSANNIQ------IDKTKP--LWHN 98
Cdd:PLN02865  33 VVSPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGDPEVLLR-SAQFEGEVRFRVDEIQhpianvSSDSKEesNWGD 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957   99 YFLCGLKGIQEhFGLSNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVT------LTVlgRNLSKVELAEICakSERYIG 172
Cdd:PLN02865 112 YARGAVYALQS-RGHALSQGITGYISGSEGLDSSGLSSSAAVGVAYLLAlenannLTV--SPEDNIELDRLI--ENEYLG 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  173 TEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAV-------FVIANSCVEMNKAATSHFNIRVMECRLAAKLLAK 245
Cdd:PLN02865 187 LRNGILDQSAILLSRYGCLTFMDCKTLDHKLVSLQFQQPggekpfkILLAFSGLRHALTNKPGYNLRVSECQEAARFLLE 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  246 YKSLqwdkvlrlEEVQAKLGisleemllvtedALHPEPYnpeeicrclgisleELRTQILSPNtqdvlifkLYQRAKHVY 325
Cdd:PLN02865 267 ASGN--------DELEPLLC------------NVEPEVY--------------EAHKCKLEAV--------LARRAEHYF 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  326 SEAARVLqfkKICEEAPENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGGCTVSMVPAD 404
Cdd:PLN02865 305 SENMRVI---KGVEAWASGNLEEFGKLISASGLSSIENYECGCEPLIQLYEILLKApGVYGARFSGAGFRGCCVAFVDAE 381

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 48527957  405 KLPSFLANVhKAYYQRSDGSLA---PEKQSLFATKPGGGALVL 444
Cdd:PLN02865 382 MAEEAASFV-RDEYEKAQPELAsniNGDKPVLICEAGDCARVL 423
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 29-396 7.86e-14

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 71.41  E-value: 7.86e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  29 APGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTYALQLantnplYPDFSTSANNIQIDKTKPLwhNYFLCGLKGIQ 108
Cdd:COG1577   1 APGKLILFGEHAVVYGQPAIAVAVDRRATVTVEPSDDDKLRI------ESPDLGGTLDLDPLADAAL--RYIKAAIEAAL 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957 109 EHFGLSNlTGMNCLVDGNIPPSsglssssalvccAGL-----VT-------LTVLGRNLSKVELAEICAKSERYIGTEGG 176
Cdd:COG1577  73 EYLGLPL-KGFDIEIDSEIPRK------------RGLgssaaVAvaviralAAFYGVELSKEELFKLALEAEKIVHGNPS 139

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957 177 GMDQSISFLaeEGtakLIEF-SPLRATDVKLPSGAVFVIANSCVemnKAATSHfnirvmecrLAAKLLAKYKSlqwdkvl 255
Cdd:COG1577 140 GLDTAASTY--GG---PIYYqRGDRAEPLELPKNLPLVVGDTGV---PASTKE---------LVAKVRKLKER------- 195

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957 256 rleevqaklgisleemllvtedalHPEPYNPeeicrclgisleelrtqilspntqdvlifkLYQRAKHVYSEAARVLQfk 335
Cdd:COG1577 196 ------------------------NPELYEA------------------------------FLEEIGDLVEEAIEALE-- 219

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 48527957 336 kiceeapENMVQLLGELMNQSHmscRDMYE--CSCPELDQLVDICRKFGAQGSRLTGAGWGGC 396
Cdd:COG1577 220 -------EGDLEALGELMNENH---GLLRAlgVSTPELDRLVEAARKAGALGAKLTGAGGGGC 272
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 316-400 2.64e-11

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 64.49  E-value: 2.64e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957  316 KLYQRAKHVYSEAARVLQfkkiceeapENMVQLLGELMNQSHMSCRDMyECSCPELDQLVDICRKFGAQGSRLTGAGWGG 395
Cdd:PTZ00298 218 RLLENYNACVSEAKEALQ---------KGNLFRVGELMNANHDLCQKL-TVSCRELDSIVQTCRTYGALGAKMSGTGRGG 287


                 ....*
gi 48527957  396 CTVSM 400
Cdd:PTZ00298 288 LVVAL 292
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 29-398 1.54e-10

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 61.54  E-value: 1.54e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957    29 APGRVNIIGEHIDYCGYSVLPMAVEQ-DVLIAVEPVKTYALQLANTNPLYPDFSTSANNIqidktkplwHNYFLCGLKgi 107
Cdd:TIGR00549   1 APGKIILFGEHAVVYGEPAIAAPIPLrTTVTVIESSDGSFIESDLGRGSLDDAPDELDGL---------KYVLAEFLS-- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957   108 qeHFGLSNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSERYIGTEGGGMDQSISflae 187
Cdd:TIGR00549  70 --RFSELNPPPLEITIESEIPPGRGLGSSAAVAVALIRALADYFGSELSKEELAELANEAEKIAHGKPSGIDTATS---- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957   188 eGTAKLIEFSPLRATDVKLPS-GAVFVIANSCVEmnkaatshfnirvmecRLAAKLLAKYKSLqwdkvlrLEEvqaklgi 266
Cdd:TIGR00549 144 -TSGGPVYFEKGEGEFTKLISlDGYFVIADTGVS----------------GSTKEAVARVRQL-------LER------- 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957   267 sleemllvtedalHPEpynpeeicrclgisleelrtqilspntqdvLIFKLYQRAKHVYSEAARVLQFKKiceeapenmV 346
Cdd:TIGR00549 193 -------------FPE------------------------------LIDSIMDAIGELTLEAKAALQDGD---------V 220

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 48527957   347 QLLGELMNQSHmSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTV 398
Cdd:TIGR00549 221 ESLGELMNINQ-GLLKALGVSHPKLDQLVEIARKAGALGAKLTGAGGGGCMI 271
PRK03926 PRK03926
mevalonate kinase; Provisional
 349-405 1.82e-08

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 55.44  E-value: 1.82e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 48527957  349 LGELMNQSHmSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSMVPADK 405
Cdd:PRK03926 216 LGELMNINQ-GLLDALGVSTKELSELIYAARTAGALGAKITGAGGGGCMVALAAPEK 271
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 339-419 2.18e-08

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 51.32  E-value: 2.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957   339 EEAPENMVQLLGELMNQSHMSC--RDMYECSCPELDQLVDICRKFGAqGSRLTGAGWGGCTVSMVP-ADKLPSFLANVHK 415
Cdd:pfam08544   3 EALLRGDLEELGKLLTESAESLepLLVVGILPPELDELLEALLELGL-GAKLSGSGGGPTVFALFKdEDDAEEVARALRE 81


                  ....
gi 48527957   416 AYYQ 419
Cdd:pfam08544  82 AGKK 85
COG2605 COG2605
Predicted kinase related to galactokinase and mevalonate kinase [General function prediction ...
 319-428 1.06e-05

Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only];


Pssm-ID: 442017 [Multi-domain]  Cd Length: 328  Bit Score: 47.10  E-value: 1.06e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48527957 319 QRAKHVYSEAARVLQFKKICEEApENMVQLL--------GELMNQSHMSCRDMYE-CSCPELDQLVDICRKFGAQGSRLT 389
Cdd:COG2605 205 QVKNVEDGDEATLEALHEMKELA-LEMKEALlkgdldefGELLNEGWELKKRLASgISNPAIDEIYELARKAGALGGKLL 283

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 48527957 390 GAGWGGCTVSMVPADKLPSFLANVHKAYYQRSDGSLAPE 428
Cdd:COG2605 284 GAGGGGFLLFYAPPERREAVREALSKAGLRVVPFSFDKE 322
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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