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Conserved domains on  [gi|111548668|ref|NP_001001411|]
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zinc finger protein 676 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
195-580 9.68e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.41  E-value: 9.68e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111548668 195 KPYKCEECGKAFSKFSILTKHKVIHTGEKPYKC--EECGKAFNRSSILTKHKIIHTGEKPYKCE-ECGKGFSSVSTLNTH 271
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111548668 272 KAIHAEEKPYKCEECGKASN----------SSSKLME--HKRIHTGEKPYKC-----------EECGKAFSWSSSLTEHK 328
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSsrdpqlpdllSISNLRNnpLPGNNSSSVNTPQsnslhpplpanSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111548668 329 RIHAGEKPYKCEECGKA------------FNRSSILTKHKIIHTGEKPYKCEgcgkafSKVSTLNTHKAIHAEEKPYKC- 395
Cdd:COG5048  192 VSTSIPSSSENSPLSSSysipssssdqnlENSSSSLPLTTNSQLSPKSLLSQ------SPSSLSSSDSSSSASESPRSSl 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111548668 396 --EECGKASNSSSKLMEHKRIHTgekPYKCEECGKAFSWSSSLTEHKR--IHAGE--KPYKCEE--CGKAFTWSSSFTKH 467
Cdd:COG5048  266 ptASSQSSSPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111548668 468 KRIHAAEKPYKC--EECGKGFSTFSI------LTKHKIIHTGEKRYKCEECGKAFSWS-SILTEHKIIHTGEKP--YKCE 536
Cdd:COG5048  343 ILLHTSISPAKEklLNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLSNSCIRNFKRdSNLSLHIITHLSFRPynCKNP 422

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 111548668 537 ECGKAFSRSSSLTRHKRIHTGEKPYKCEECGKAFKSSSTVSYHK 580
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
KRAB super family cl42959
krueppel associated box;
1-32 1.31e-11

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 59.91  E-value: 1.31e-11
                           10        20        30
                   ....*....|....*....|....*....|..
gi 111548668     1 MLENYRNLVFLGIAAFKPDLIIFLEQGKEPWN 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
195-580 9.68e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.41  E-value: 9.68e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111548668 195 KPYKCEECGKAFSKFSILTKHKVIHTGEKPYKC--EECGKAFNRSSILTKHKIIHTGEKPYKCE-ECGKGFSSVSTLNTH 271
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111548668 272 KAIHAEEKPYKCEECGKASN----------SSSKLME--HKRIHTGEKPYKC-----------EECGKAFSWSSSLTEHK 328
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSsrdpqlpdllSISNLRNnpLPGNNSSSVNTPQsnslhpplpanSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111548668 329 RIHAGEKPYKCEECGKA------------FNRSSILTKHKIIHTGEKPYKCEgcgkafSKVSTLNTHKAIHAEEKPYKC- 395
Cdd:COG5048  192 VSTSIPSSSENSPLSSSysipssssdqnlENSSSSLPLTTNSQLSPKSLLSQ------SPSSLSSSDSSSSASESPRSSl 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111548668 396 --EECGKASNSSSKLMEHKRIHTgekPYKCEECGKAFSWSSSLTEHKR--IHAGE--KPYKCEE--CGKAFTWSSSFTKH 467
Cdd:COG5048  266 ptASSQSSSPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111548668 468 KRIHAAEKPYKC--EECGKGFSTFSI------LTKHKIIHTGEKRYKCEECGKAFSWS-SILTEHKIIHTGEKP--YKCE 536
Cdd:COG5048  343 ILLHTSISPAKEklLNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLSNSCIRNFKRdSNLSLHIITHLSFRPynCKNP 422

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 111548668 537 ECGKAFSRSSSLTRHKRIHTGEKPYKCEECGKAFKSSSTVSYHK 580
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
KRAB smart00349
krueppel associated box;
1-32 1.31e-11

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 59.91  E-value: 1.31e-11
                           10        20        30
                   ....*....|....*....|....*....|..
gi 111548668     1 MLENYRNLVFLGIAAFKPDLIIFLEQGKEPWN 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
zf-H2C2_2 pfam13465
Zinc-finger double domain;
547-572 5.92e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 5.92e-05
                          10        20
                  ....*....|....*....|....*.
gi 111548668  547 SLTRHKRIHTGEKPYKCEECGKAFKS 572
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
195-580 9.68e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.41  E-value: 9.68e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111548668 195 KPYKCEECGKAFSKFSILTKHKVIHTGEKPYKC--EECGKAFNRSSILTKHKIIHTGEKPYKCE-ECGKGFSSVSTLNTH 271
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111548668 272 KAIHAEEKPYKCEECGKASN----------SSSKLME--HKRIHTGEKPYKC-----------EECGKAFSWSSSLTEHK 328
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSsrdpqlpdllSISNLRNnpLPGNNSSSVNTPQsnslhpplpanSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111548668 329 RIHAGEKPYKCEECGKA------------FNRSSILTKHKIIHTGEKPYKCEgcgkafSKVSTLNTHKAIHAEEKPYKC- 395
Cdd:COG5048  192 VSTSIPSSSENSPLSSSysipssssdqnlENSSSSLPLTTNSQLSPKSLLSQ------SPSSLSSSDSSSSASESPRSSl 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111548668 396 --EECGKASNSSSKLMEHKRIHTgekPYKCEECGKAFSWSSSLTEHKR--IHAGE--KPYKCEE--CGKAFTWSSSFTKH 467
Cdd:COG5048  266 ptASSQSSSPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111548668 468 KRIHAAEKPYKC--EECGKGFSTFSI------LTKHKIIHTGEKRYKCEECGKAFSWS-SILTEHKIIHTGEKP--YKCE 536
Cdd:COG5048  343 ILLHTSISPAKEklLNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLSNSCIRNFKRdSNLSLHIITHLSFRPynCKNP 422

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 111548668 537 ECGKAFSRSSSLTRHKRIHTGEKPYKCEECGKAFKSSSTVSYHK 580
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
KRAB smart00349
krueppel associated box;
1-32 1.31e-11

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 59.91  E-value: 1.31e-11
                           10        20        30
                   ....*....|....*....|....*....|..
gi 111548668     1 MLENYRNLVFLGIAAFKPDLIIFLEQGKEPWN 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
290-588 2.24e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 2.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111548668 290 SNSSSKLMEHKRIHTGE----KPYKCEECGKAFSWSSSLTEHKRIHAGEKPYKC--EECGKAFNRSSILTKHKIIHTGEK 363
Cdd:COG5048   11 SNNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNP 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111548668 364 PYKCE-GCGKAFSKVSTLNTHKAIHAEEKPYKCEECGKASN----------SSSKLME--HKRIHTGEKPYKC------- 423
Cdd:COG5048   91 SDLNSkSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSsrdpqlpdllSISNLRNnpLPGNNSSSVNTPQsnslhpp 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111548668 424 ----EECGKAFSWSSSLTEHKRIHAGEKPYKCEECGKAFTWSSSFTKHKRIHAAEkPYKCEECGKGFSTFSILTKHKIIH 499
Cdd:COG5048  171 lpanSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLSQSPSSLS 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111548668 500 TGEKRYKCEECGKAFSWSSILTEHKIIHTGE-------KPYKCEECGKAFSRSSSLTRHKR--IHTGE--KPYKCEE--C 566
Cdd:COG5048  250 SSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslC 329

                        330       340
                 ....*....|....*....|..
gi 111548668 567 GKAFKSSSTVSYHKKIHTGENP 588
Cdd:COG5048  330 GKLFSRNDALKRHILLHTSISP 351
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
263-575 4.20e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.78  E-value: 4.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111548668 263 SSVSTLNTHKAIHAEEKPYKCEECGKASNSSSKLMEHKRIHTGEKPYKC--EECGKAFSWSSSLTEHKRIHAGEKPYkcE 340
Cdd:COG5048   16 LSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSD--L 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111548668 341 ECGKAFNRSSILTKHKIIHTGEKPYKCE-----GCGKAFSKVSTLNTHKAIHAEEKPYK--------------------- 394
Cdd:COG5048   94 NSKSLPLSNSKASSSSLSSSSSNSNDNNllsshSLPPSSRDPQLPDLLSISNLRNNPLPgnnsssvntpqsnslhpplpa 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111548668 395 CEECGKASNSSSKLMEHKRIHTGEKPYKCEECGKAFSWSSSLTEHKRIHAgEKPYKCEECGKAF-----TWSSSFTKHK- 468
Cdd:COG5048  174 NSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSpksllSQSPSSLSSSd 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111548668 469 RIHAAEKPYKCEECGKGFSTFSILTKHKIIHTG-EKRYKCEECGKAFSWSSILTEHK--IIHTGE--KPYKCEE--CGKA 541
Cdd:COG5048  253 SSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKL 332

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 111548668 542 FSRSSSLTRHKRIHTGEKPYKC--EECGKAFKSSST 575
Cdd:COG5048  333 FSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLN 368
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
195-385 1.16e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 1.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111548668 195 KPYKCEECGKAFSKFSILTKHK--VIHTGE--KPYKCEE--CGKAFNRSSILTKHKIIHTGEKPYKCEECGKGFSSVSTL 268
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111548668 269 NthkaihaeekpykceecgkaSNSSSKLMEHKRIHTGEKPYKCEECGKAFSWSSS-LTEHKRIHAGEKPY--KCEECGKA 345
Cdd:COG5048  368 N--------------------NEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSnLSLHIITHLSFRPYncKNPPCSKS 427

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 111548668 346 FNRSSILTKHKIIHTGEKPYKCEGCGKAFSKVSTLNTHKA 385
Cdd:COG5048  428 FNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
547-572 5.92e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 5.92e-05
                          10        20
                  ....*....|....*....|....*.
gi 111548668  547 SLTRHKRIHTGEKPYKCEECGKAFKS 572
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 529-581 1.01e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 1.01e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 111548668 529 GEKPYKCE--ECGKAFSRSSSLTRHKR-------------------IHTGEKPYKCEECGKAFKSSSTVSYHKK 581
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
296-319 2.22e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.22e-04
                          10        20
                  ....*....|....*....|....
gi 111548668  296 LMEHKRIHTGEKPYKCEECGKAFS 319
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
408-431 2.22e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.22e-04
                          10        20
                  ....*....|....*....|....
gi 111548668  408 LMEHKRIHTGEKPYKCEECGKAFS 431
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 305-384 2.35e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 2.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111548668 305 GEKPYKCE--ECGKAFSWSSSLTEHkRIHAGEKPYKCEecgkafNRSSIltKHKIIHTGEKPYKCEGCGKAFSKVSTLNT 382
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQKLHE------NPSPE--KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 111548668 383 HK 384
Cdd:COG5189  417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 417-496 3.39e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 3.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111548668 417 GEKPYKCE--ECGKAFSWSSSLTEHkRIHAgekpykceECGKAFTWSSSFTKHKRIHAAEKPYKCEECGKGFSTFSILTK 494
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 111548668 495 HK 496
Cdd:COG5189  417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
520-544 1.42e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.42e-03
                          10        20
                  ....*....|....*....|....*
gi 111548668  520 LTEHKIIHTGEKPYKCEECGKAFSR 544
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 333-412 1.44e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111548668 333 GEKPYKCE--ECGKAFNRSSILTKHKIihtgekpykcEG-CGKAFSKVSTLNTHKAIHAEEKPYKCEECGKASNSSSKLM 409
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML----------HGhQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ...
gi 111548668 410 EHK 412
Cdd:COG5189  416 YHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
323-348 1.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.66e-03
                          10        20
                  ....*....|....*....|....*.
gi 111548668  323 SLTEHKRIHAGEKPYKCEECGKAFNR 348
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
212-236 2.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.02e-03
                          10        20
                  ....*....|....*....|....*
gi 111548668  212 LTKHKVIHTGEKPYKCEECGKAFNR 236
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 533-555 2.16e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 2.16e-03
                          10        20
                  ....*....|....*....|...
gi 111548668  533 YKCEECGKAFSRSSSLTRHKRIH 555
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 193-272 2.68e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111548668 193 GEKPYKCE--ECGKAFSKFSILTKHKvIHTGEKPYKCEecgkafNRSSIltKHKIIHTGEKPYKCEECGKGFSSVSTLNT 270
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM-LHGHQNQKLHE------NPSPE--KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 111548668 271 HK 272
Cdd:COG5189  417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 221-300 2.87e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111548668 221 GEKPYKCE--ECGKAFNRSSILTKHKiihtgekpyKCEECGKGFSSVSTLNTHKAIHAEEKPYKCEECGKASNSSSKLME 298
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 111548668 299 HK 300
Cdd:COG5189  417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
435-459 3.24e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.24e-03
                          10        20
                  ....*....|....*....|....*
gi 111548668  435 SLTEHKRIHAGEKPYKCEECGKAFT 459
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
240-264 3.58e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.58e-03
                          10        20
                  ....*....|....*....|....*
gi 111548668  240 LTKHKIIHTGEKPYKCEECGKGFSS 264
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
352-376 7.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.78e-03
                          10        20
                  ....*....|....*....|....*
gi 111548668  352 LTKHKIIHTGEKPYKCEGCGKAFSK 376
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
492-515 8.75e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.75e-03
                          10        20
                  ....*....|....*....|....
gi 111548668  492 LTKHKIIHTGEKRYKCEECGKAFS 515
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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