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Conserved domains on  [gi|4557431|ref|NP_000725|]
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T-cell surface glycoprotein CD3 zeta chain isoform 2 precursor [Homo sapiens]

Protein Classification

TCR_zetazeta and ITAM domain-containing protein( domain architecture ID 10569225)

TCR_zetazeta and ITAM domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TCR_zetazeta pfam11628
T-cell surface glycoprotein CD3 zeta chain; The incorporation of the zetazeta signalling ...
 28-58 1.57e-15

T-cell surface glycoprotein CD3 zeta chain; The incorporation of the zetazeta signalling module requires one basic TCR alpha and two zetazeta aspartic acid TM residues. The structure of the zetazeta(TM) dimer consists of a left-handed coiled coil with polar contacts. Two aspartic acids are critical for zetazeta dimerization and assembly with TCR.


:

Pssm-ID: 463313  Cd Length: 31  Bit Score: 66.18  E-value: 1.57e-15
                          10        20        30
                  ....*....|....*....|....*....|.
gi 4557431     28 DPKLCYLLDGILFIYGVILTALFLRVKFSRS 58
Cdd:pfam11628   1 DPRLCYILDGILFIYGIIITALFCREKFSKS 31
ITAM super family cl02452
Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on ...
 69-89 6.31e-04

Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery.


The actual alignment was detected with superfamily member smart00077:

Pssm-ID: 128390  Cd Length: 21  Bit Score: 35.44  E-value: 6.31e-04
                           10        20
                   ....*....|....*....|.
gi 4557431      69 NQLYNELNLGRREEYDVLDKR 89
Cdd:smart00077   1 DQLYQPLNKRQRDTYSDLNTR 21
ITAM super family cl02452
Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on ...
 138-158 2.46e-03

Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery.


The actual alignment was detected with superfamily member smart00077:

Pssm-ID: 128390  Cd Length: 21  Bit Score: 33.90  E-value: 2.46e-03
                           10        20
                   ....*....|....*....|.
gi 4557431     138 DGLYQGLSTATKDTYDALHMQ 158
Cdd:smart00077   1 DQLYQPLNKRQRDTYSDLNTR 21
 
Name Accession Description Interval E-value
TCR_zetazeta pfam11628
T-cell surface glycoprotein CD3 zeta chain; The incorporation of the zetazeta signalling ...
 28-58 1.57e-15

T-cell surface glycoprotein CD3 zeta chain; The incorporation of the zetazeta signalling module requires one basic TCR alpha and two zetazeta aspartic acid TM residues. The structure of the zetazeta(TM) dimer consists of a left-handed coiled coil with polar contacts. Two aspartic acids are critical for zetazeta dimerization and assembly with TCR.


Pssm-ID: 463313  Cd Length: 31  Bit Score: 66.18  E-value: 1.57e-15
                          10        20        30
                  ....*....|....*....|....*....|.
gi 4557431     28 DPKLCYLLDGILFIYGVILTALFLRVKFSRS 58
Cdd:pfam11628   1 DPRLCYILDGILFIYGIIITALFCREKFSKS 31
ITAM smart00077
Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on ...
 69-89 6.31e-04

Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery.


Pssm-ID: 128390  Cd Length: 21  Bit Score: 35.44  E-value: 6.31e-04
                           10        20
                   ....*....|....*....|.
gi 4557431      69 NQLYNELNLGRREEYDVLDKR 89
Cdd:smart00077   1 DQLYQPLNKRQRDTYSDLNTR 21
ITAM smart00077
Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on ...
 138-158 2.46e-03

Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery.


Pssm-ID: 128390  Cd Length: 21  Bit Score: 33.90  E-value: 2.46e-03
                           10        20
                   ....*....|....*....|.
gi 4557431     138 DGLYQGLSTATKDTYDALHMQ 158
Cdd:smart00077   1 DQLYQPLNKRQRDTYSDLNTR 21
ITAM pfam02189
Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex ...
 138-157 6.24e-03

Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex multi-protein cell surface receptor composed of the ligand-sensing TCR heterodimer and three signaling subunits. These signaling subunits contain cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) with a consensus sequence of YxxL/Ix6-12YxxL/I. The two tyrosines are phosphorylated by a Src kinase, Lck or Fyn. Binding of the dually phosphorylated ITAM peptide reorients the two SH2 domains relative to each other, destabilizing inhibitory interactions made by the linker connecting the SH2 and kinase domains.


Pssm-ID: 426646  Cd Length: 20  Bit Score: 32.74  E-value: 6.24e-03
                          10        20
                  ....*....|....*....|
gi 4557431    138 DGLYQGLSTATKDTYDALHM 157
Cdd:pfam02189   1 DQLYQPLNKRDDDTYSHLGM 20
ITAM pfam02189
Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex ...
 69-88 7.26e-03

Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex multi-protein cell surface receptor composed of the ligand-sensing TCR heterodimer and three signaling subunits. These signaling subunits contain cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) with a consensus sequence of YxxL/Ix6-12YxxL/I. The two tyrosines are phosphorylated by a Src kinase, Lck or Fyn. Binding of the dually phosphorylated ITAM peptide reorients the two SH2 domains relative to each other, destabilizing inhibitory interactions made by the linker connecting the SH2 and kinase domains.


Pssm-ID: 426646  Cd Length: 20  Bit Score: 32.35  E-value: 7.26e-03
                          10        20
                  ....*....|....*....|
gi 4557431     69 NQLYNELNLGRREEYDVLDK 88
Cdd:pfam02189   1 DQLYQPLNKRDDDTYSHLGM 20
 
Name Accession Description Interval E-value
TCR_zetazeta pfam11628
T-cell surface glycoprotein CD3 zeta chain; The incorporation of the zetazeta signalling ...
 28-58 1.57e-15

T-cell surface glycoprotein CD3 zeta chain; The incorporation of the zetazeta signalling module requires one basic TCR alpha and two zetazeta aspartic acid TM residues. The structure of the zetazeta(TM) dimer consists of a left-handed coiled coil with polar contacts. Two aspartic acids are critical for zetazeta dimerization and assembly with TCR.


Pssm-ID: 463313  Cd Length: 31  Bit Score: 66.18  E-value: 1.57e-15
                          10        20        30
                  ....*....|....*....|....*....|.
gi 4557431     28 DPKLCYLLDGILFIYGVILTALFLRVKFSRS 58
Cdd:pfam11628   1 DPRLCYILDGILFIYGIIITALFCREKFSKS 31
ITAM smart00077
Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on ...
 69-89 6.31e-04

Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery.


Pssm-ID: 128390  Cd Length: 21  Bit Score: 35.44  E-value: 6.31e-04
                           10        20
                   ....*....|....*....|.
gi 4557431      69 NQLYNELNLGRREEYDVLDKR 89
Cdd:smart00077   1 DQLYQPLNKRQRDTYSDLNTR 21
ITAM smart00077
Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on ...
 138-158 2.46e-03

Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery.


Pssm-ID: 128390  Cd Length: 21  Bit Score: 33.90  E-value: 2.46e-03
                           10        20
                   ....*....|....*....|.
gi 4557431     138 DGLYQGLSTATKDTYDALHMQ 158
Cdd:smart00077   1 DQLYQPLNKRQRDTYSDLNTR 21
ITAM pfam02189
Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex ...
 138-157 6.24e-03

Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex multi-protein cell surface receptor composed of the ligand-sensing TCR heterodimer and three signaling subunits. These signaling subunits contain cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) with a consensus sequence of YxxL/Ix6-12YxxL/I. The two tyrosines are phosphorylated by a Src kinase, Lck or Fyn. Binding of the dually phosphorylated ITAM peptide reorients the two SH2 domains relative to each other, destabilizing inhibitory interactions made by the linker connecting the SH2 and kinase domains.


Pssm-ID: 426646  Cd Length: 20  Bit Score: 32.74  E-value: 6.24e-03
                          10        20
                  ....*....|....*....|
gi 4557431    138 DGLYQGLSTATKDTYDALHM 157
Cdd:pfam02189   1 DQLYQPLNKRDDDTYSHLGM 20
ITAM pfam02189
Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex ...
 69-88 7.26e-03

Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex multi-protein cell surface receptor composed of the ligand-sensing TCR heterodimer and three signaling subunits. These signaling subunits contain cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) with a consensus sequence of YxxL/Ix6-12YxxL/I. The two tyrosines are phosphorylated by a Src kinase, Lck or Fyn. Binding of the dually phosphorylated ITAM peptide reorients the two SH2 domains relative to each other, destabilizing inhibitory interactions made by the linker connecting the SH2 and kinase domains.


Pssm-ID: 426646  Cd Length: 20  Bit Score: 32.35  E-value: 7.26e-03
                          10        20
                  ....*....|....*....|
gi 4557431     69 NQLYNELNLGRREEYDVLDK 88
Cdd:pfam02189   1 DQLYQPLNKRDDDTYSHLGM 20
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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