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Conserved domains on  [gi|4502671|ref|NP_000724|]
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T-cell surface glycoprotein CD3 epsilon chain precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgC1_CD3_epsilon cd07692
Immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 epsilon chain; member of ...
 36-117 5.72e-40

Immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 epsilon chain; member of the C1-set of IgSF domains; The members here are composed of the immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 epsilon chain. CD3 is a T cell surface receptor that is associated with alpha/beta T cell receptors (TCRs). The CD3 complex consists of one gamma, one delta, two epsilon, and two zeta chains. The CD3 subunits form heterodimers as gamma/epsilon, delta/epsilon, and zeta/zeta. The gamma, delta, and epsilon chains each contain an extracellular Ig domain, whereas the extracellular domains of the zeta chains are very small and have unknown structure. The CD3 domain participates in intracellular signaling once the TCR has bound an MHC/antigen complex.


:

Pssm-ID: 409489  Cd Length: 75  Bit Score: 131.24  E-value: 5.72e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502671   36 YKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDeddkniGSDEDHLSLKEFSELEQSGYYVCYPRGSkPEDANFYLYLR 115
Cdd:cd07692   1 YKVSISGTSVELTCPKDFENGIQWKRNDNNEQMK------GHNEKYLSLKEFSEMESSGYYQCYATEG-NTEAAHYLYLR 73


                ..
gi 4502671  116 AR 117
Cdd:cd07692  74 AR 75
ITAM smart00077
Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on ...
 185-205 2.58e-04

Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery.


:

Pssm-ID: 128390  Cd Length: 21  Bit Score: 36.98  E-value: 2.58e-04
                           10        20
                   ....*....|....*....|.
gi 4502671     185 NPDYEPIRKGQRDLYSGLNQR 205
Cdd:smart00077   1 DQLYQPLNKRQRDTYSDLNTR 21
 
Name Accession Description Interval E-value
IgC1_CD3_epsilon cd07692
Immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 epsilon chain; member of ...
 36-117 5.72e-40

Immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 epsilon chain; member of the C1-set of IgSF domains; The members here are composed of the immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 epsilon chain. CD3 is a T cell surface receptor that is associated with alpha/beta T cell receptors (TCRs). The CD3 complex consists of one gamma, one delta, two epsilon, and two zeta chains. The CD3 subunits form heterodimers as gamma/epsilon, delta/epsilon, and zeta/zeta. The gamma, delta, and epsilon chains each contain an extracellular Ig domain, whereas the extracellular domains of the zeta chains are very small and have unknown structure. The CD3 domain participates in intracellular signaling once the TCR has bound an MHC/antigen complex.


Pssm-ID: 409489  Cd Length: 75  Bit Score: 131.24  E-value: 5.72e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502671   36 YKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDeddkniGSDEDHLSLKEFSELEQSGYYVCYPRGSkPEDANFYLYLR 115
Cdd:cd07692   1 YKVSISGTSVELTCPKDFENGIQWKRNDNNEQMK------GHNEKYLSLKEFSEMESSGYYQCYATEG-NTEAAHYLYLR 73


                ..
gi 4502671  116 AR 117
Cdd:cd07692  74 AR 75
Ig_5 pfam16681
Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain; Ig_5 is an immunoglobulin ...
 36-121 3.99e-32

Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain; Ig_5 is an immunoglobulin domain found on T-cell surface glycoprotein CD3 epsilon chain. It forms a first-order complex with T-cell surface glycoprotein CD3 delta chain as part of the T-cell receptor complex.


Pssm-ID: 465232  Cd Length: 75  Bit Score: 111.26  E-value: 3.99e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502671     36 YKVSISGTTVILTCPQYPGSEILWQHNDKNIGgdeddkniGSDEDHLSLKEFSELEQSGYYVCYPRGSKpedANFYLYLR 115
Cdd:pfam16681   1 YKVSISGTTVTLTCPLDSEEKIKWEKNDKPLE--------DSNDLELKLENFSEMEDSGYYSCYSSNSN---KTHYLYLK 69


                  ....*.
gi 4502671    116 ARVCEN 121
Cdd:pfam16681  70 ARVCEN 75
ITAM smart00077
Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on ...
 185-205 2.58e-04

Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery.


Pssm-ID: 128390  Cd Length: 21  Bit Score: 36.98  E-value: 2.58e-04
                           10        20
                   ....*....|....*....|.
gi 4502671     185 NPDYEPIRKGQRDLYSGLNQR 205
Cdd:smart00077   1 DQLYQPLNKRQRDTYSDLNTR 21
ITAM pfam02189
Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex ...
 185-204 4.72e-03

Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex multi-protein cell surface receptor composed of the ligand-sensing TCR heterodimer and three signaling subunits. These signaling subunits contain cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) with a consensus sequence of YxxL/Ix6-12YxxL/I. The two tyrosines are phosphorylated by a Src kinase, Lck or Fyn. Binding of the dually phosphorylated ITAM peptide reorients the two SH2 domains relative to each other, destabilizing inhibitory interactions made by the linker connecting the SH2 and kinase domains.


Pssm-ID: 426646  Cd Length: 20  Bit Score: 33.51  E-value: 4.72e-03
                          10        20
                  ....*....|....*....|
gi 4502671    185 NPDYEPIRKGQRDLYSGLNQ 204
Cdd:pfam02189   1 DQLYQPLNKRDDDTYSHLGM 20
 
Name Accession Description Interval E-value
IgC1_CD3_epsilon cd07692
Immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 epsilon chain; member of ...
 36-117 5.72e-40

Immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 epsilon chain; member of the C1-set of IgSF domains; The members here are composed of the immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 epsilon chain. CD3 is a T cell surface receptor that is associated with alpha/beta T cell receptors (TCRs). The CD3 complex consists of one gamma, one delta, two epsilon, and two zeta chains. The CD3 subunits form heterodimers as gamma/epsilon, delta/epsilon, and zeta/zeta. The gamma, delta, and epsilon chains each contain an extracellular Ig domain, whereas the extracellular domains of the zeta chains are very small and have unknown structure. The CD3 domain participates in intracellular signaling once the TCR has bound an MHC/antigen complex.


Pssm-ID: 409489  Cd Length: 75  Bit Score: 131.24  E-value: 5.72e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502671   36 YKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDeddkniGSDEDHLSLKEFSELEQSGYYVCYPRGSkPEDANFYLYLR 115
Cdd:cd07692   1 YKVSISGTSVELTCPKDFENGIQWKRNDNNEQMK------GHNEKYLSLKEFSEMESSGYYQCYATEG-NTEAAHYLYLR 73


                ..
gi 4502671  116 AR 117
Cdd:cd07692  74 AR 75
Ig_5 pfam16681
Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain; Ig_5 is an immunoglobulin ...
 36-121 3.99e-32

Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain; Ig_5 is an immunoglobulin domain found on T-cell surface glycoprotein CD3 epsilon chain. It forms a first-order complex with T-cell surface glycoprotein CD3 delta chain as part of the T-cell receptor complex.


Pssm-ID: 465232  Cd Length: 75  Bit Score: 111.26  E-value: 3.99e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502671     36 YKVSISGTTVILTCPQYPGSEILWQHNDKNIGgdeddkniGSDEDHLSLKEFSELEQSGYYVCYPRGSKpedANFYLYLR 115
Cdd:pfam16681   1 YKVSISGTTVTLTCPLDSEEKIKWEKNDKPLE--------DSNDLELKLENFSEMEDSGYYSCYSSNSN---KTHYLYLK 69


                  ....*.
gi 4502671    116 ARVCEN 121
Cdd:pfam16681  70 ARVCEN 75
Ig_4 pfam16680
T-cell surface glycoprotein CD3 delta chain; This is an immunoglobulin-like domain. It is ...
 42-118 3.03e-12

T-cell surface glycoprotein CD3 delta chain; This is an immunoglobulin-like domain. It is found on the T-cell surface glycoprotein CD3 delta chain. CD3delta and CD3epsilon complex together as part of the T-cell receptor complex.


Pssm-ID: 465231  Cd Length: 63  Bit Score: 59.19  E-value: 3.03e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4502671     42 GTTVILTCPQYpGSEILWQHNDKNIGgdeddkniGSDEDHLSLKEFSElEQSGYYVCYPrgskPEDANFYLYLRARV 118
Cdd:pfam16680   1 DGKVLLTCNSS-SKSITWLKDGKGIK--------STNTKTLDLGKFSE-DPRGLYQCQG----EKKKSSTLQVYYRM 63
ITAM smart00077
Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on ...
 185-205 2.58e-04

Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery.


Pssm-ID: 128390  Cd Length: 21  Bit Score: 36.98  E-value: 2.58e-04
                           10        20
                   ....*....|....*....|.
gi 4502671     185 NPDYEPIRKGQRDLYSGLNQR 205
Cdd:smart00077   1 DQLYQPLNKRQRDTYSDLNTR 21
ITAM pfam02189
Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex ...
 185-204 4.72e-03

Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex multi-protein cell surface receptor composed of the ligand-sensing TCR heterodimer and three signaling subunits. These signaling subunits contain cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) with a consensus sequence of YxxL/Ix6-12YxxL/I. The two tyrosines are phosphorylated by a Src kinase, Lck or Fyn. Binding of the dually phosphorylated ITAM peptide reorients the two SH2 domains relative to each other, destabilizing inhibitory interactions made by the linker connecting the SH2 and kinase domains.


Pssm-ID: 426646  Cd Length: 20  Bit Score: 33.51  E-value: 4.72e-03
                          10        20
                  ....*....|....*....|
gi 4502671    185 NPDYEPIRKGQRDLYSGLNQ 204
Cdd:pfam02189   1 DQLYQPLNKRDDDTYSHLGM 20
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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