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Conserved domains on  [gi|88853069|ref|NP_000629|]
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vitronectin precursor [Homo sapiens]

Protein Classification

SO and HX domain-containing protein( domain architecture ID 10640906)

SO and HX domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 154-472 1.19e-45

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


:

Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 157.47  E-value: 1.19e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88853069 154 ELCSGKPFDAFTDLkNGSLFAFRGQYCYELDEKaVRPGYPKLIRDVW-GIEGPIDAAFTRINcQGKTYLFKGSQYWRFED 232
Cdd:cd00094   2 DACDPLSFDAVTTL-RGELYFFKGRYFWRLSPG-KPPGSPFLISSFWpSLPSPVDAAFERPD-TGKIYFFKGDKYWVYTG 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88853069 233 GVLDPDYPRNISD-GFDGIPDNVDAALALPAhsysgRERVYFFKGKQYWEYQFQHQPSQEECegsslsavfehfammqrd 311
Cdd:cd00094  79 KNLEPGYPKPISDlGFPPTVKQIDAALRWPD-----NGKTYFFKGDKYWRYDEKTQKMDPGY------------------ 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88853069 312 swedifellfwgrtsagtrqPQFISRDWHGVPGQVDAAMagriyisgmaprpslakkqrfrhRNRKGYrsqrghsrgrnq 391
Cdd:cd00094 136 --------------------PKLIETDFPGVPDKVDAAF-----------------------RWLDGY------------ 160

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88853069 392 nsrrpsratwlslfsseesnlgannyddyrmdwlvpatcepiqsVFFFSGDKYYRVNLRTRRvdtVDPPYPRSIAQYWLG 471
Cdd:cd00094 161 --------------------------------------------YYFFKGDQYWRFDPRSKE---VRVGYPLKISSDWLG 193


                .
gi 88853069 472 C 472
Cdd:cd00094 194 C 194
SO smart00201
Somatomedin B -like domains; Somatomedin-B is a peptide, proteolytically excised from ...
 20-62 1.73e-16

Somatomedin B -like domains; Somatomedin-B is a peptide, proteolytically excised from vitronectin, that is a growth hormone-dependent serum factor with protease-inhibiting activity.


:

Pssm-ID: 197571  Cd Length: 43  Bit Score: 72.79  E-value: 1.73e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 88853069     20 DQESCKGRCTEGFNVDKKCQCDELCSYYQSCCTDYTAECKPQV 62
Cdd:smart00201   1 AIGSCKGRCGESFNEGNACRCDALCLSYGDCCTDYESVCKKEV 43
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 154-472 1.19e-45

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 157.47  E-value: 1.19e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88853069 154 ELCSGKPFDAFTDLkNGSLFAFRGQYCYELDEKaVRPGYPKLIRDVW-GIEGPIDAAFTRINcQGKTYLFKGSQYWRFED 232
Cdd:cd00094   2 DACDPLSFDAVTTL-RGELYFFKGRYFWRLSPG-KPPGSPFLISSFWpSLPSPVDAAFERPD-TGKIYFFKGDKYWVYTG 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88853069 233 GVLDPDYPRNISD-GFDGIPDNVDAALALPAhsysgRERVYFFKGKQYWEYQFQHQPSQEECegsslsavfehfammqrd 311
Cdd:cd00094  79 KNLEPGYPKPISDlGFPPTVKQIDAALRWPD-----NGKTYFFKGDKYWRYDEKTQKMDPGY------------------ 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88853069 312 swedifellfwgrtsagtrqPQFISRDWHGVPGQVDAAMagriyisgmaprpslakkqrfrhRNRKGYrsqrghsrgrnq 391
Cdd:cd00094 136 --------------------PKLIETDFPGVPDKVDAAF-----------------------RWLDGY------------ 160

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88853069 392 nsrrpsratwlslfsseesnlgannyddyrmdwlvpatcepiqsVFFFSGDKYYRVNLRTRRvdtVDPPYPRSIAQYWLG 471
Cdd:cd00094 161 --------------------------------------------YYFFKGDQYWRFDPRSKE---VRVGYPLKISSDWLG 193


                .
gi 88853069 472 C 472
Cdd:cd00094 194 C 194
SO smart00201
Somatomedin B -like domains; Somatomedin-B is a peptide, proteolytically excised from ...
 20-62 1.73e-16

Somatomedin B -like domains; Somatomedin-B is a peptide, proteolytically excised from vitronectin, that is a growth hormone-dependent serum factor with protease-inhibiting activity.


Pssm-ID: 197571  Cd Length: 43  Bit Score: 72.79  E-value: 1.73e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 88853069     20 DQESCKGRCTEGFNVDKKCQCDELCSYYQSCCTDYTAECKPQV 62
Cdd:smart00201   1 AIGSCKGRCGESFNEGNACRCDALCLSYGDCCTDYESVCKKEV 43
Somatomedin_B pfam01033
Somatomedin B domain;
22-61 2.13e-14

Somatomedin B domain;


Pssm-ID: 460034  Cd Length: 40  Bit Score: 66.94  E-value: 2.13e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 88853069    22 ESCKGRCTEGFNVDKKCQCDELCSYYQSCCTDYTAECKPQ 61
Cdd:pfam01033   1 ESCKGRCGESFDRGRLCQCDDDCVKYGDCCPDYESLCLGE 40
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 206-251 3.43e-12

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 60.72  E-value: 3.43e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 88853069    206 IDAAFTRINcqGKTYLFKGSQYWRFEDGVLDPDYPRNISDGFDGIP 251
Cdd:smart00120   1 IDAAFELRD--GKTYFFKGDKYWRFDPKRVDPGYPKLISSFFPGLP 44
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 206-251 1.17e-10

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 56.42  E-value: 1.17e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 88853069   206 IDAAFTRINcqGKTYLFKGSQYWRFEDGVLDPDYPRNISDgFDGIP 251
Cdd:pfam00045   1 IDAAFEDRD--GKTYFFKGRKYWRFDPQRVEPGYPKLISD-FPGLP 43
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 154-472 1.19e-45

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 157.47  E-value: 1.19e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88853069 154 ELCSGKPFDAFTDLkNGSLFAFRGQYCYELDEKaVRPGYPKLIRDVW-GIEGPIDAAFTRINcQGKTYLFKGSQYWRFED 232
Cdd:cd00094   2 DACDPLSFDAVTTL-RGELYFFKGRYFWRLSPG-KPPGSPFLISSFWpSLPSPVDAAFERPD-TGKIYFFKGDKYWVYTG 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88853069 233 GVLDPDYPRNISD-GFDGIPDNVDAALALPAhsysgRERVYFFKGKQYWEYQFQHQPSQEECegsslsavfehfammqrd 311
Cdd:cd00094  79 KNLEPGYPKPISDlGFPPTVKQIDAALRWPD-----NGKTYFFKGDKYWRYDEKTQKMDPGY------------------ 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88853069 312 swedifellfwgrtsagtrqPQFISRDWHGVPGQVDAAMagriyisgmaprpslakkqrfrhRNRKGYrsqrghsrgrnq 391
Cdd:cd00094 136 --------------------PKLIETDFPGVPDKVDAAF-----------------------RWLDGY------------ 160

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88853069 392 nsrrpsratwlslfsseesnlgannyddyrmdwlvpatcepiqsVFFFSGDKYYRVNLRTRRvdtVDPPYPRSIAQYWLG 471
Cdd:cd00094 161 --------------------------------------------YYFFKGDQYWRFDPRSKE---VRVGYPLKISSDWLG 193


                .
gi 88853069 472 C 472
Cdd:cd00094 194 C 194
SO smart00201
Somatomedin B -like domains; Somatomedin-B is a peptide, proteolytically excised from ...
 20-62 1.73e-16

Somatomedin B -like domains; Somatomedin-B is a peptide, proteolytically excised from vitronectin, that is a growth hormone-dependent serum factor with protease-inhibiting activity.


Pssm-ID: 197571  Cd Length: 43  Bit Score: 72.79  E-value: 1.73e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 88853069     20 DQESCKGRCTEGFNVDKKCQCDELCSYYQSCCTDYTAECKPQV 62
Cdd:smart00201   1 AIGSCKGRCGESFNEGNACRCDALCLSYGDCCTDYESVCKKEV 43
Somatomedin_B pfam01033
Somatomedin B domain;
22-61 2.13e-14

Somatomedin B domain;


Pssm-ID: 460034  Cd Length: 40  Bit Score: 66.94  E-value: 2.13e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 88853069    22 ESCKGRCTEGFNVDKKCQCDELCSYYQSCCTDYTAECKPQ 61
Cdd:pfam01033   1 ESCKGRCGESFDRGRLCQCDDDCVKYGDCCPDYESLCLGE 40
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 206-251 3.43e-12

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 60.72  E-value: 3.43e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 88853069    206 IDAAFTRINcqGKTYLFKGSQYWRFEDGVLDPDYPRNISDGFDGIP 251
Cdd:smart00120   1 IDAAFELRD--GKTYFFKGDKYWRFDPKRVDPGYPKLISSFFPGLP 44
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 206-251 1.17e-10

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 56.42  E-value: 1.17e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 88853069   206 IDAAFTRINcqGKTYLFKGSQYWRFEDGVLDPDYPRNISDgFDGIP 251
Cdd:pfam00045   1 IDAAFEDRD--GKTYFFKGRKYWRFDPQRVEPGYPKLISD-FPGLP 43
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 161-200 5.80e-08

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 48.78  E-value: 5.80e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 88853069    161 FDAFTDLKNGSLFAFRGQYCYELDEKAVRPGYPKLIRDVW 200
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRFDPKRVDPGYPKLISSFF 40
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 161-203 1.56e-07

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 47.56  E-value: 1.56e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 88853069   161 FDAFTDLKNGSLFAFRGQYCYELDEKAVRPGYPKLIRDVWGIE 203
Cdd:pfam00045   1 IDAAFEDRDGKTYFFKGRKYWRFDPQRVEPGYPKLISDFPGLP 43
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 428-471 7.81e-06

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 43.00  E-value: 7.81e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 88853069    428 ATCEPIQSVFFFSGDKYYRVNlrtrrVDTVDPPYPRSIAQYWLG 471
Cdd:smart00120   4 AFELRDGKTYFFKGDKYWRFD-----PKRVDPGYPKLISSFFPG 42
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 428-472 2.54e-05

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 41.40  E-value: 2.54e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 88853069   428 ATCEPIQSVFFFSGDKYYRVNLRtrrvdTVDPPYPRSIAQY-WLGC 472
Cdd:pfam00045   4 AFEDRDGKTYFFKGRKYWRFDPQ-----RVEPGYPKLISDFpGLPC 44
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 254-285 1.11e-03

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 36.84  E-value: 1.11e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 88853069    254 VDAALalpahsYSGRERVYFFKGKQYWEYQFQ 285
Cdd:smart00120   1 IDAAF------ELRDGKTYFFKGDKYWRFDPK 26
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 254-285 9.71e-03

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 34.08  E-value: 9.71e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 88853069   254 VDAALalpahsYSGRERVYFFKGKQYWEYQFQ 285
Cdd:pfam00045   1 IDAAF------EDRDGKTYFFKGRKYWRFDPQ 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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