NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|11321561|ref|NP_000604|]
View 

hemopexin precursor [Homo sapiens]

Protein Classification

HX domain-containing protein( domain architecture ID 10056662)

HX domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 47-231 4.18e-59

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


:

Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 192.53  E-value: 4.18e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321561  47 TERCsDGWSFDATTLDdNGTMLFFKGEFVWKSH----KWDRELISERWKNFPSPVDAAFRQGH-NSVFLIKGDKVWVYPP 121
Cdd:cd00094   1 PDAC-DPLSFDAVTTL-RGELYFFKGRYFWRLSpgkpPGSPFLISSFWPSLPSPVDAAFERPDtGKIYFFKGDKYWVYTG 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321561 122 EKKEKGYPKLLQD-EFPGIPSPLDAAVECHRGEcqaeGVLFFQGDREWFWDLATGTMK-------ERSWPAVGN-CSSAL 192
Cdd:cd00094  79 KNLEPGYPKPISDlGFPPTVKQIDAALRWPDNG----KTYFFKGDKYWRYDEKTQKMDpgypkliETDFPGVPDkVDAAF 154

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 11321561 193 RWL-GRYYCFQGNQFLRFDPVRGEVPPRYPRDVRDYFMPC 231
Cdd:cd00094 155 RWLdGYYYFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 256-460 3.94e-37

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


:

Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 134.75  E-value: 3.94e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321561 256 RCSPhLVLSALTSDNhGATYAFSGTHYWRLDTSRDGWHSWPIAHQWPQGPSAVDAAFSW--EEKLYLVQGTQVYVFLtkg 333
Cdd:cd00094   3 ACDP-LSFDAVTTLR-GELYFFKGRYFWRLSPGKPPGSPFLISSFWPSLPSPVDAAFERpdTGKIYFFKGDKYWVYT--- 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321561 334 GYTLVSGYPKRLEKevgTPHGIILDSVDAAFICPGSSRLHIMAGRRLWWLDLKSGAQA------TWTELPWPHEKVDGAL 407
Cdd:cd00094  78 GKNLEPGYPKPISD---LGFPPTVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDpgypklIETDFPGVPDKVDAAF 154

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 11321561 408 CMEKSLgpnscsangpgLYLIHGPNLYCYSDVEKLNaakALPQPQNVTS-LLGC 460
Cdd:cd00094 155 RWLDGY-----------YYFFKGDQYWRFDPRSKEV---RVGYPLKISSdWLGC 194
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 47-231 4.18e-59

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 192.53  E-value: 4.18e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321561  47 TERCsDGWSFDATTLDdNGTMLFFKGEFVWKSH----KWDRELISERWKNFPSPVDAAFRQGH-NSVFLIKGDKVWVYPP 121
Cdd:cd00094   1 PDAC-DPLSFDAVTTL-RGELYFFKGRYFWRLSpgkpPGSPFLISSFWPSLPSPVDAAFERPDtGKIYFFKGDKYWVYTG 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321561 122 EKKEKGYPKLLQD-EFPGIPSPLDAAVECHRGEcqaeGVLFFQGDREWFWDLATGTMK-------ERSWPAVGN-CSSAL 192
Cdd:cd00094  79 KNLEPGYPKPISDlGFPPTVKQIDAALRWPDNG----KTYFFKGDKYWRYDEKTQKMDpgypkliETDFPGVPDkVDAAF 154

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 11321561 193 RWL-GRYYCFQGNQFLRFDPVRGEVPPRYPRDVRDYFMPC 231
Cdd:cd00094 155 RWLdGYYYFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 256-460 3.94e-37

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 134.75  E-value: 3.94e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321561 256 RCSPhLVLSALTSDNhGATYAFSGTHYWRLDTSRDGWHSWPIAHQWPQGPSAVDAAFSW--EEKLYLVQGTQVYVFLtkg 333
Cdd:cd00094   3 ACDP-LSFDAVTTLR-GELYFFKGRYFWRLSPGKPPGSPFLISSFWPSLPSPVDAAFERpdTGKIYFFKGDKYWVYT--- 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321561 334 GYTLVSGYPKRLEKevgTPHGIILDSVDAAFICPGSSRLHIMAGRRLWWLDLKSGAQA------TWTELPWPHEKVDGAL 407
Cdd:cd00094  78 GKNLEPGYPKPISD---LGFPPTVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDpgypklIETDFPGVPDKVDAAF 154

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 11321561 408 CMEKSLgpnscsangpgLYLIHGPNLYCYSDVEKLNaakALPQPQNVTS-LLGC 460
Cdd:cd00094 155 RWLDGY-----------YYFFKGDQYWRFDPRSKEV---RVGYPLKISSdWLGC 194
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 97-141 4.25e-11

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 57.64  E-value: 4.25e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 11321561     97 VDAAFRQGHNSVFLIKGDKVWVYPPEKKEKGYPKLLQDEFPGIPS 141
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRFDPKRVDPGYPKLISSFFPGLPC 45
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 97-141 8.49e-10

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 54.11  E-value: 8.49e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 11321561    97 VDAAFRQGHNSVFLIKGDKVWVYPPEKKEKGYPKLLQDeFPGIPS 141
Cdd:pfam00045   1 IDAAFEDRDGKTYFFKGRKYWRFDPQRVEPGYPKLISD-FPGLPC 44
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 263-306 4.13e-05

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 40.69  E-value: 4.13e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 11321561    263 LSALTSDNHGATYAFSGTHYWRLDTSR-DGWHSWPIAHQWPQGPS 306
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRFDPKRvDPGYPKLISSFFPGLPC 45
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 263-306 4.74e-04

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 37.55  E-value: 4.74e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 11321561   263 LSALTSDNHGATYAFSGTHYWRLDTSR-DGWHSWPIAHqWPQGPS 306
Cdd:pfam00045   1 IDAAFEDRDGKTYFFKGRKYWRFDPQRvEPGYPKLISD-FPGLPC 44
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 47-231 4.18e-59

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 192.53  E-value: 4.18e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321561  47 TERCsDGWSFDATTLDdNGTMLFFKGEFVWKSH----KWDRELISERWKNFPSPVDAAFRQGH-NSVFLIKGDKVWVYPP 121
Cdd:cd00094   1 PDAC-DPLSFDAVTTL-RGELYFFKGRYFWRLSpgkpPGSPFLISSFWPSLPSPVDAAFERPDtGKIYFFKGDKYWVYTG 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321561 122 EKKEKGYPKLLQD-EFPGIPSPLDAAVECHRGEcqaeGVLFFQGDREWFWDLATGTMK-------ERSWPAVGN-CSSAL 192
Cdd:cd00094  79 KNLEPGYPKPISDlGFPPTVKQIDAALRWPDNG----KTYFFKGDKYWRYDEKTQKMDpgypkliETDFPGVPDkVDAAF 154

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 11321561 193 RWL-GRYYCFQGNQFLRFDPVRGEVPPRYPRDVRDYFMPC 231
Cdd:cd00094 155 RWLdGYYYFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 256-460 3.94e-37

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 134.75  E-value: 3.94e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321561 256 RCSPhLVLSALTSDNhGATYAFSGTHYWRLDTSRDGWHSWPIAHQWPQGPSAVDAAFSW--EEKLYLVQGTQVYVFLtkg 333
Cdd:cd00094   3 ACDP-LSFDAVTTLR-GELYFFKGRYFWRLSPGKPPGSPFLISSFWPSLPSPVDAAFERpdTGKIYFFKGDKYWVYT--- 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321561 334 GYTLVSGYPKRLEKevgTPHGIILDSVDAAFICPGSSRLHIMAGRRLWWLDLKSGAQA------TWTELPWPHEKVDGAL 407
Cdd:cd00094  78 GKNLEPGYPKPISD---LGFPPTVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDpgypklIETDFPGVPDKVDAAF 154

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 11321561 408 CMEKSLgpnscsangpgLYLIHGPNLYCYSDVEKLNaakALPQPQNVTS-LLGC 460
Cdd:cd00094 155 RWLDGY-----------YYFFKGDQYWRFDPRSKEV---RVGYPLKISSdWLGC 194
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 97-141 4.25e-11

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 57.64  E-value: 4.25e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 11321561     97 VDAAFRQGHNSVFLIKGDKVWVYPPEKKEKGYPKLLQDEFPGIPS 141
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRFDPKRVDPGYPKLISSFFPGLPC 45
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 97-141 8.49e-10

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 54.11  E-value: 8.49e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 11321561    97 VDAAFRQGHNSVFLIKGDKVWVYPPEKKEKGYPKLLQDeFPGIPS 141
Cdd:pfam00045   1 IDAAFEDRDGKTYFFKGRKYWRFDPQRVEPGYPKLISD-FPGLPC 44
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 56-95 1.05e-05

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 42.23  E-value: 1.05e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 11321561     56 FDATTLDDNGTMLFFKGEFVWKSH-----KWDRELISERWKNFPS 95
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRFDpkrvdPGYPKLISSFFPGLPC 45
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 263-306 4.13e-05

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 40.69  E-value: 4.13e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 11321561    263 LSALTSDNHGATYAFSGTHYWRLDTSR-DGWHSWPIAHQWPQGPS 306
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRFDPKRvDPGYPKLISSFFPGLPC 45
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 191-231 9.16e-05

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 39.86  E-value: 9.16e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 11321561   191 ALRW-LGRYYCFQGNQFLRFDPVRgeVPPRYPRDVRDY-FMPC 231
Cdd:pfam00045   4 AFEDrDGKTYFFKGRKYWRFDPQR--VEPGYPKLISDFpGLPC 44
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 263-306 4.74e-04

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 37.55  E-value: 4.74e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 11321561   263 LSALTSDNHGATYAFSGTHYWRLDTSR-DGWHSWPIAHqWPQGPS 306
Cdd:pfam00045   1 IDAAFEDRDGKTYFFKGRKYWRFDPQRvEPGYPKLISD-FPGLPC 44
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 196-231 5.44e-04

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 37.61  E-value: 5.44e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 11321561    196 GRYYCFQGNQFLRFDPVRgeVPPRYPRDVRDYF--MPC 231
Cdd:smart00120  10 GKTYFFKGDKYWRFDPKR--VDPGYPKLISSFFpgLPC 45
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 56-95 1.03e-03

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 36.78  E-value: 1.03e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 11321561    56 FDATTLDDNGTMLFFKGEFVWKSH-----KWDRELISErWKNFPS 95
Cdd:pfam00045   1 IDAAFEDRDGKTYFFKGRKYWRFDpqrvePGYPKLISD-FPGLPC 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH