NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|19923106|ref|NP_000437|]
View 

serum paraoxonase/arylesterase 1 [Homo sapiens]

Protein Classification

strictosidine synthase family protein( domain architecture ID 13399701)

strictosidine synthase family protein with similarity to strictosidine synthase that catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Arylesterase pfam01731
Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1. ...
 168-253 2.36e-50

Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1.2. These enzymes hydrolyse organophosphorus esters such as paraoxon and are found in the liver and blood. They confer resistance to organophosphate toxicity. Human arylesterase (PON1) is associated with HDL and may protect against LDL oxidation.


:

Pssm-ID: 334656  Cd Length: 86  Bit Score: 163.02  E-value: 2.36e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923106   168 NDIVAVGPEHFYGTNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAELLAHKIHV 247
Cdd:pfam01731   1 NDIVAVGPDSFYATNDHYFGDPFLQNLEMYLGLIWTGVVYYSPSEVKVVASGFSFANGINYSPDKKYIYVASSLRHSIHV 80


                  ....*.
gi 19923106   248 YEKHAN 253
Cdd:pfam01731  81 MKKHAN 86
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 83-318 2.24e-14

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


:

Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 72.23  E-value: 2.24e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923106  83 GKILLMDLNEEDPTVlelgitgskFDVSSFNPHGIsTFTDEDNamyLLVVNHPDAkstveLFKFQEEEKSLLHLKTIRHK 162
Cdd:COG3386  29 GRIHRYDPDGGAVEV---------FAEPSGRPNGL-AFDPDGR---LLVADHGRG-----LVRFDPADGEVTVLADEYGK 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923106 163 LLPNLNDIVaVGPE-HFYGTNdhyfldpylqsweMYLGLAWSYVVYYSPS-EVRVVAEGFDFANGINISPDGKYVYIAEL 240
Cdd:COG3386  91 PLNRPNDGV-VDPDgRLYFTD-------------MGEYLPTGALYRVDPDgSLRVLADGLTFPNGIAFSPDGRTLYVADT 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923106 241 LAHKIHVYEKHANWTLT---PLKSLDFNTLV-DNISVDPEtGDLWVgCHPNGMKIFFYDsenpPASEVLRIqnILTEEPK 316
Cdd:COG3386 157 GAGRIYRFDLDADGTLGnrrVFADLPDGPGGpDGLAVDAD-GNLWV-ALWGGGGVVRFD----PDGELLGR--IELPERR 228


                ..
gi 19923106 317 VT 318
Cdd:COG3386 229 PT 230
 
Name Accession Description Interval E-value
Arylesterase pfam01731
Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1. ...
 168-253 2.36e-50

Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1.2. These enzymes hydrolyse organophosphorus esters such as paraoxon and are found in the liver and blood. They confer resistance to organophosphate toxicity. Human arylesterase (PON1) is associated with HDL and may protect against LDL oxidation.


Pssm-ID: 334656  Cd Length: 86  Bit Score: 163.02  E-value: 2.36e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923106   168 NDIVAVGPEHFYGTNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAELLAHKIHV 247
Cdd:pfam01731   1 NDIVAVGPDSFYATNDHYFGDPFLQNLEMYLGLIWTGVVYYSPSEVKVVASGFSFANGINYSPDKKYIYVASSLRHSIHV 80


                  ....*.
gi 19923106   248 YEKHAN 253
Cdd:pfam01731  81 MKKHAN 86
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 83-318 2.24e-14

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 72.23  E-value: 2.24e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923106  83 GKILLMDLNEEDPTVlelgitgskFDVSSFNPHGIsTFTDEDNamyLLVVNHPDAkstveLFKFQEEEKSLLHLKTIRHK 162
Cdd:COG3386  29 GRIHRYDPDGGAVEV---------FAEPSGRPNGL-AFDPDGR---LLVADHGRG-----LVRFDPADGEVTVLADEYGK 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923106 163 LLPNLNDIVaVGPE-HFYGTNdhyfldpylqsweMYLGLAWSYVVYYSPS-EVRVVAEGFDFANGINISPDGKYVYIAEL 240
Cdd:COG3386  91 PLNRPNDGV-VDPDgRLYFTD-------------MGEYLPTGALYRVDPDgSLRVLADGLTFPNGIAFSPDGRTLYVADT 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923106 241 LAHKIHVYEKHANWTLT---PLKSLDFNTLV-DNISVDPEtGDLWVgCHPNGMKIFFYDsenpPASEVLRIqnILTEEPK 316
Cdd:COG3386 157 GAGRIYRFDLDADGTLGnrrVFADLPDGPGGpDGLAVDAD-GNLWV-ALWGGGGVVRFD----PDGELLGR--IELPERR 228


                ..
gi 19923106 317 VT 318
Cdd:COG3386 229 PT 230
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 211-307 7.22e-07

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 49.57  E-value: 7.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923106   211 SEVRVVAEGFDFANGINISPDGKYVYIAELLAHKIHVYEKHANWTLTPLKSL-----DFNTLVDNISVDPEtGDLWVgCH 285
Cdd:pfam08450 124 GKLTRVLDGLTISNGLAWSPDGRTLYFADSPARKIWAYDYDLDGGLISNRRVfadfkPGLGRPDGMAVDAE-GNVWV-AR 201

                          90       100
                  ....*....|....*....|..
gi 19923106   286 PNGMKIFFYDsenpPASEVLRI 307
Cdd:pfam08450 202 WGGGKVVRFD----PDGKLLRE 219
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
212-288 1.54e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 39.68  E-value: 1.54e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19923106 212 EVRVVAEGfDFANGINISPDGKYVYIAELLAHKIHVY-EKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNG 288
Cdd:COG3391 144 VVATIPVG-AGPHGIAVDPDGKRLYVANSGSNTVSVIvSVIDTATGKVVATIPVGGGPVGVAVSPDGRRLYVANRGSN 220
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 205-250 2.84e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 39.11  E-value: 2.84e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 19923106 205 VVYYSPSE--VRVVAEGFDFA--NGINISPDGKYVYIAELLAHKIHVYEK 250
Cdd:cd14962  80 VFVFDRDGkfLRAIGAGALFKrpTGIAVDPAGKRLYVVDTLAHKVKVFDL 129
 
Name Accession Description Interval E-value
Arylesterase pfam01731
Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1. ...
 168-253 2.36e-50

Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1.2. These enzymes hydrolyse organophosphorus esters such as paraoxon and are found in the liver and blood. They confer resistance to organophosphate toxicity. Human arylesterase (PON1) is associated with HDL and may protect against LDL oxidation.


Pssm-ID: 334656  Cd Length: 86  Bit Score: 163.02  E-value: 2.36e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923106   168 NDIVAVGPEHFYGTNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAELLAHKIHV 247
Cdd:pfam01731   1 NDIVAVGPDSFYATNDHYFGDPFLQNLEMYLGLIWTGVVYYSPSEVKVVASGFSFANGINYSPDKKYIYVASSLRHSIHV 80


                  ....*.
gi 19923106   248 YEKHAN 253
Cdd:pfam01731  81 MKKHAN 86
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 83-318 2.24e-14

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 72.23  E-value: 2.24e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923106  83 GKILLMDLNEEDPTVlelgitgskFDVSSFNPHGIsTFTDEDNamyLLVVNHPDAkstveLFKFQEEEKSLLHLKTIRHK 162
Cdd:COG3386  29 GRIHRYDPDGGAVEV---------FAEPSGRPNGL-AFDPDGR---LLVADHGRG-----LVRFDPADGEVTVLADEYGK 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923106 163 LLPNLNDIVaVGPE-HFYGTNdhyfldpylqsweMYLGLAWSYVVYYSPS-EVRVVAEGFDFANGINISPDGKYVYIAEL 240
Cdd:COG3386  91 PLNRPNDGV-VDPDgRLYFTD-------------MGEYLPTGALYRVDPDgSLRVLADGLTFPNGIAFSPDGRTLYVADT 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923106 241 LAHKIHVYEKHANWTLT---PLKSLDFNTLV-DNISVDPEtGDLWVgCHPNGMKIFFYDsenpPASEVLRIqnILTEEPK 316
Cdd:COG3386 157 GAGRIYRFDLDADGTLGnrrVFADLPDGPGGpDGLAVDAD-GNLWV-ALWGGGGVVRFD----PDGELLGR--IELPERR 228


                ..
gi 19923106 317 VT 318
Cdd:COG3386 229 PT 230
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 211-307 7.22e-07

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 49.57  E-value: 7.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923106   211 SEVRVVAEGFDFANGINISPDGKYVYIAELLAHKIHVYEKHANWTLTPLKSL-----DFNTLVDNISVDPEtGDLWVgCH 285
Cdd:pfam08450 124 GKLTRVLDGLTISNGLAWSPDGRTLYFADSPARKIWAYDYDLDGGLISNRRVfadfkPGLGRPDGMAVDAE-GNVWV-AR 201

                          90       100
                  ....*....|....*....|..
gi 19923106   286 PNGMKIFFYDsenpPASEVLRI 307
Cdd:pfam08450 202 WGGGKVVRFD----PDGKLLRE 219
Str_synth pfam03088
Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid ...
 179-248 2.48e-05

Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid biosynthesis. It catalyzes the condensation of tryptamine with secologanin to form strictosidine.


Pssm-ID: 281131 [Multi-domain]  Cd Length: 89  Bit Score: 42.43  E-value: 2.48e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19923106   179 YGTNDHYFLDPYLQSWEMYLGLAWSYVVYYSPS--EVRVVAEGFDFANGINISPDGKYVYIAELLAHKIHVY 248
Cdd:pfam03088  13 YFTDSSSRYDRRQVIAAFLEGDATGRLMKYDPTtkVTKVLLDDLYFPNGIALSPDGSFVLFCETPMARISRY 84
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
212-288 1.54e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 39.68  E-value: 1.54e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19923106 212 EVRVVAEGfDFANGINISPDGKYVYIAELLAHKIHVY-EKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNG 288
Cdd:COG3391 144 VVATIPVG-AGPHGIAVDPDGKRLYVANSGSNTVSVIvSVIDTATGKVVATIPVGGGPVGVAVSPDGRRLYVANRGSN 220
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 205-250 2.84e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 39.11  E-value: 2.84e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 19923106 205 VVYYSPSE--VRVVAEGFDFA--NGINISPDGKYVYIAELLAHKIHVYEK 250
Cdd:cd14962  80 VFVFDRDGkfLRAIGAGALFKrpTGIAVDPAGKRLYVVDTLAHKVKVFDL 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH