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Conserved domains on  [gi|4557669|ref|NP_000409|]
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interleukin-4 receptor subunit alpha isoform a precursor [Homo sapiens]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10557929)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
IL4Ra_N pfam09238
Interleukin-4 receptor alpha chain, N-terminal; Members of this family are related in overall ...
28-121 3.16e-55

Interleukin-4 receptor alpha chain, N-terminal; Members of this family are related in overall topology to fibronectin type III modules and fold into a sandwich comprising seven antiparallel beta sheets arranged in a three-strand and a four-strand beta-pleated sheet. They are required for binding of interleukin-4 to the receptor alpha chain, which is a crucial event for the generation of a Th2-dominated early immune response.


:

Pssm-ID: 462720  Cd Length: 94  Bit Score: 184.88  E-value: 3.16e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557669     28 VLQEPTCVSDYMSISTCEWKMNGPTNCSTELRLLYQLVFLLSEAHTCIPENNGGAGCVCHLLMDDVVSADNYTLDLWAGQ 107
Cdd:pfam09238   1 VLQEPTCFSDYISTSTCEWKMDSPTNCSSELLLSYQLDFEFSENLTCVPENSEDAVCVCKMLMDDFVSADTYSLELWAGG 80
                          90
                  ....*....|....
gi 4557669    108 QLLWKGSFKPSEHV 121
Cdd:pfam09238  81 QLLWQGSFKPSEHV 94
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
123-219 1.04e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 47.49  E-value: 1.04e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557669  123 PRAPGNLTVHTNVSDTLLLTWSnpyPPDNYLYNHLTYAVNIWSENDPADFRIYNVTYLEPSLRIaaSTLKSGISYRARVR 202
Cdd:cd00063   1 PSPPTNLRVTDVTSTSVTLSWT---PPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTL--TGLKPGTEYEFRVR 75
                        90
                ....*....|....*..
gi 4557669  203 AWaqcYNTTWSEWSPST 219
Cdd:cd00063  76 AV---NGGGESPPSESV 89
PHA03247 super family cl33720
large tegument protein UL36; Provisional
434-702 3.68e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 3.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557669    434 PPSGSTSAHMPWDEFPSAGPKEAPPWGKEQPLHLEPSPPASPTQ--SPDNLTCTETPLVIAGNPAyrsfsnslSQSPCPR 511
Cdd:PHA03247 2704 PPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGpaTPGGPARPARPPTTAGPPA--------PAPPAAP 2775
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557669    512 ELGPDPLLARhleevepemPCVPQLSEPTtvpQPEPETWEQilrrnvlqhGAAAAPVSAPTSGYQefvhaveqggTQASA 591
Cdd:PHA03247 2776 AAGPPRRLTR---------PAVASLSESR---ESLPSPWDP---------ADPPAAVLAPAAALP----------PAASP 2824
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557669    592 VVGLGPPGEAGYKAFSSLLASSAVSPEKCGFGASSGEEGYKPFQDLIPGCPGDPAPVPVPLFTfglDREPPRSPQSSHLP 671
Cdd:PHA03247 2825 AGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLA---RPAVSRSTESFALP 2901
                         250       260       270
                  ....*....|....*....|....*....|.
gi 4557669    672 SSSPEHLglepgeKVEDMPKPPLPQEQATDP 702
Cdd:PHA03247 2902 PDQPERP------PQPQAPPPPQPQPQPPPP 2926
 
Name Accession Description Interval E-value
IL4Ra_N pfam09238
Interleukin-4 receptor alpha chain, N-terminal; Members of this family are related in overall ...
28-121 3.16e-55

Interleukin-4 receptor alpha chain, N-terminal; Members of this family are related in overall topology to fibronectin type III modules and fold into a sandwich comprising seven antiparallel beta sheets arranged in a three-strand and a four-strand beta-pleated sheet. They are required for binding of interleukin-4 to the receptor alpha chain, which is a crucial event for the generation of a Th2-dominated early immune response.


Pssm-ID: 462720  Cd Length: 94  Bit Score: 184.88  E-value: 3.16e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557669     28 VLQEPTCVSDYMSISTCEWKMNGPTNCSTELRLLYQLVFLLSEAHTCIPENNGGAGCVCHLLMDDVVSADNYTLDLWAGQ 107
Cdd:pfam09238   1 VLQEPTCFSDYISTSTCEWKMDSPTNCSSELLLSYQLDFEFSENLTCVPENSEDAVCVCKMLMDDFVSADTYSLELWAGG 80
                          90
                  ....*....|....
gi 4557669    108 QLLWKGSFKPSEHV 121
Cdd:pfam09238  81 QLLWQGSFKPSEHV 94
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
123-219 1.04e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 47.49  E-value: 1.04e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557669  123 PRAPGNLTVHTNVSDTLLLTWSnpyPPDNYLYNHLTYAVNIWSENDPADFRIYNVTYLEPSLRIaaSTLKSGISYRARVR 202
Cdd:cd00063   1 PSPPTNLRVTDVTSTSVTLSWT---PPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTL--TGLKPGTEYEFRVR 75
                        90
                ....*....|....*..
gi 4557669  203 AWaqcYNTTWSEWSPST 219
Cdd:cd00063  76 AV---NGGGESPPSESV 89
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
123-203 7.56e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.91  E-value: 7.56e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557669     123 PRAPGNLTVHTNVSDTLLLTWSNPYPPDNYLYnHLTYAVNIWSENDpaDFRIYNVTYLEPSLRIaaSTLKSGISYRARVR 202
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGY-IVGYRVEYREEGS--EWKEVNVTPSSTSYTL--TGLKPGTEYEFRVR 75

                   .
gi 4557669     203 A 203
Cdd:smart00060  76 A 76
fn3 pfam00041
Fibronectin type III domain;
125-216 1.48e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.16  E-value: 1.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557669    125 APGNLTVHTNVSDTLLLTWSNPYPPDNYLynhLTYAVNIWSENDPADFRIYNVTYLEPSLRIaaSTLKSGISYRARVRAw 204
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPI---TGYEVEYRPKNSGEPWNEITVPGTTTSVTL--TGLKPGTEYEVRVQA- 75
                          90
                  ....*....|..
gi 4557669    205 aqCYNTTWSEWS 216
Cdd:pfam00041  76 --VNGGGEGPPS 85
PHA03247 PHA03247
large tegument protein UL36; Provisional
434-702 3.68e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 3.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557669    434 PPSGSTSAHMPWDEFPSAGPKEAPPWGKEQPLHLEPSPPASPTQ--SPDNLTCTETPLVIAGNPAyrsfsnslSQSPCPR 511
Cdd:PHA03247 2704 PPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGpaTPGGPARPARPPTTAGPPA--------PAPPAAP 2775
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557669    512 ELGPDPLLARhleevepemPCVPQLSEPTtvpQPEPETWEQilrrnvlqhGAAAAPVSAPTSGYQefvhaveqggTQASA 591
Cdd:PHA03247 2776 AAGPPRRLTR---------PAVASLSESR---ESLPSPWDP---------ADPPAAVLAPAAALP----------PAASP 2824
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557669    592 VVGLGPPGEAGYKAFSSLLASSAVSPEKCGFGASSGEEGYKPFQDLIPGCPGDPAPVPVPLFTfglDREPPRSPQSSHLP 671
Cdd:PHA03247 2825 AGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLA---RPAVSRSTESFALP 2901
                         250       260       270
                  ....*....|....*....|....*....|.
gi 4557669    672 SSSPEHLglepgeKVEDMPKPPLPQEQATDP 702
Cdd:PHA03247 2902 PDQPERP------PQPQAPPPPQPQPQPPPP 2926
 
Name Accession Description Interval E-value
IL4Ra_N pfam09238
Interleukin-4 receptor alpha chain, N-terminal; Members of this family are related in overall ...
28-121 3.16e-55

Interleukin-4 receptor alpha chain, N-terminal; Members of this family are related in overall topology to fibronectin type III modules and fold into a sandwich comprising seven antiparallel beta sheets arranged in a three-strand and a four-strand beta-pleated sheet. They are required for binding of interleukin-4 to the receptor alpha chain, which is a crucial event for the generation of a Th2-dominated early immune response.


Pssm-ID: 462720  Cd Length: 94  Bit Score: 184.88  E-value: 3.16e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557669     28 VLQEPTCVSDYMSISTCEWKMNGPTNCSTELRLLYQLVFLLSEAHTCIPENNGGAGCVCHLLMDDVVSADNYTLDLWAGQ 107
Cdd:pfam09238   1 VLQEPTCFSDYISTSTCEWKMDSPTNCSSELLLSYQLDFEFSENLTCVPENSEDAVCVCKMLMDDFVSADTYSLELWAGG 80
                          90
                  ....*....|....
gi 4557669    108 QLLWKGSFKPSEHV 121
Cdd:pfam09238  81 QLLWQGSFKPSEHV 94
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
123-219 1.04e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 47.49  E-value: 1.04e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557669  123 PRAPGNLTVHTNVSDTLLLTWSnpyPPDNYLYNHLTYAVNIWSENDPADFRIYNVTYLEPSLRIaaSTLKSGISYRARVR 202
Cdd:cd00063   1 PSPPTNLRVTDVTSTSVTLSWT---PPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTL--TGLKPGTEYEFRVR 75
                        90
                ....*....|....*..
gi 4557669  203 AWaqcYNTTWSEWSPST 219
Cdd:cd00063  76 AV---NGGGESPPSESV 89
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
123-203 7.56e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.91  E-value: 7.56e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557669     123 PRAPGNLTVHTNVSDTLLLTWSNPYPPDNYLYnHLTYAVNIWSENDpaDFRIYNVTYLEPSLRIaaSTLKSGISYRARVR 202
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGY-IVGYRVEYREEGS--EWKEVNVTPSSTSYTL--TGLKPGTEYEFRVR 75

                   .
gi 4557669     203 A 203
Cdd:smart00060  76 A 76
fn3 pfam00041
Fibronectin type III domain;
125-216 1.48e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.16  E-value: 1.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557669    125 APGNLTVHTNVSDTLLLTWSNPYPPDNYLynhLTYAVNIWSENDPADFRIYNVTYLEPSLRIaaSTLKSGISYRARVRAw 204
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPI---TGYEVEYRPKNSGEPWNEITVPGTTTSVTL--TGLKPGTEYEVRVQA- 75
                          90
                  ....*....|..
gi 4557669    205 aqCYNTTWSEWS 216
Cdd:pfam00041  76 --VNGGGEGPPS 85
PHA03247 PHA03247
large tegument protein UL36; Provisional
434-702 3.68e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 3.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557669    434 PPSGSTSAHMPWDEFPSAGPKEAPPWGKEQPLHLEPSPPASPTQ--SPDNLTCTETPLVIAGNPAyrsfsnslSQSPCPR 511
Cdd:PHA03247 2704 PPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGpaTPGGPARPARPPTTAGPPA--------PAPPAAP 2775
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557669    512 ELGPDPLLARhleevepemPCVPQLSEPTtvpQPEPETWEQilrrnvlqhGAAAAPVSAPTSGYQefvhaveqggTQASA 591
Cdd:PHA03247 2776 AAGPPRRLTR---------PAVASLSESR---ESLPSPWDP---------ADPPAAVLAPAAALP----------PAASP 2824
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557669    592 VVGLGPPGEAGYKAFSSLLASSAVSPEKCGFGASSGEEGYKPFQDLIPGCPGDPAPVPVPLFTfglDREPPRSPQSSHLP 671
Cdd:PHA03247 2825 AGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLA---RPAVSRSTESFALP 2901
                         250       260       270
                  ....*....|....*....|....*....|.
gi 4557669    672 SSSPEHLglepgeKVEDMPKPPLPQEQATDP 702
Cdd:PHA03247 2902 PDQPERP------PQPQAPPPPQPQPQPPPP 2926
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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