NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|4504073|ref|NP_000398|]
View 

platelet glycoprotein Ib beta chain precursor [Homo sapiens]

Protein Classification

LRRNT and LRRCT domain-containing protein( domain architecture ID 10635600)

LRRNT and LRRCT domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRRCT smart00082
Leucine rich repeat C-terminal domain;
89-135 2.52e-08

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.58  E-value: 2.52e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 4504073      89 NPWRCDCRLVPLRAWLAGRPERAPYRDLRCVAPPALRGRLLPYLAED 135
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSE 47
LRRNT smart00013
Leucine rich repeat N-terminal domain;
25-59 3.00e-05

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 39.61  E-value: 3.00e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 4504073      25 GCPAPCSCAGTLVDCGRRGLTwaSLPTAFPVDTTE 59
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLT--EVPLDLPPDTTL 33
 
Name Accession Description Interval E-value
LRRCT smart00082
Leucine rich repeat C-terminal domain;
89-135 2.52e-08

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.58  E-value: 2.52e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 4504073      89 NPWRCDCRLVPLRAWLAGRPERAPYRDLRCVAPPALRGRLLPYLAED 135
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSE 47
LRRNT smart00013
Leucine rich repeat N-terminal domain;
25-59 3.00e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 39.61  E-value: 3.00e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 4504073      25 GCPAPCSCAGTLVDCGRRGLTwaSLPTAFPVDTTE 59
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLT--EVPLDLPPDTTL 33
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 62-143 2.01e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 41.61  E-value: 2.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504073      62 LTGNNLTALPPGLLDALPALRTAHLGANPWRCDCRLVPLRAWL------AGRPERApyrdlRCVAPPALRGRLL---PYL 132
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAeekgvkVRQPEAA-----LCAGPGALAGQPLlgiPLL 76

                           90
                   ....*....|...
gi 4504073     133 AE--DELRAACAP 143
Cdd:TIGR00864   77 DSgcDEEYVACLK 89
 
Name Accession Description Interval E-value
LRRCT smart00082
Leucine rich repeat C-terminal domain;
89-135 2.52e-08

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.58  E-value: 2.52e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 4504073      89 NPWRCDCRLVPLRAWLAGRPERAPYRDLRCVAPPALRGRLLPYLAED 135
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSE 47
LRRNT smart00013
Leucine rich repeat N-terminal domain;
25-59 3.00e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 39.61  E-value: 3.00e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 4504073      25 GCPAPCSCAGTLVDCGRRGLTwaSLPTAFPVDTTE 59
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLT--EVPLDLPPDTTL 33
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 62-143 2.01e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 41.61  E-value: 2.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504073      62 LTGNNLTALPPGLLDALPALRTAHLGANPWRCDCRLVPLRAWL------AGRPERApyrdlRCVAPPALRGRLL---PYL 132
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAeekgvkVRQPEAA-----LCAGPGALAGQPLlgiPLL 76

                           90
                   ....*....|...
gi 4504073     133 AE--DELRAACAP 143
Cdd:TIGR00864   77 DSgcDEEYVACLK 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH