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Conserved domains on  [gi|21361183|ref|NP_000316|]
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pituitary homeobox 2 isoform c [Homo sapiens]

Protein Classification

homeobox domain-containing protein( domain architecture ID 11079034)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes; also contains an OAR domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
93-149 2.52e-29

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 106.43  E-value: 2.52e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 21361183    93 RRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRK 149
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
OAR pfam03826
OAR motif; The entry represents the OAR motif.
 282-299 2.17e-05

OAR motif; The entry represents the OAR motif.


:

Pssm-ID: 461067  Cd Length: 19  Bit Score: 40.47  E-value: 2.17e-05
                          10
                  ....*....|....*...
gi 21361183   282 DTCNSSLASLRLKAKQHS 299
Cdd:pfam03826   1 DRRSSSIASLRLKAKEHS 18
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
93-149 2.52e-29

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 106.43  E-value: 2.52e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 21361183    93 RRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRK 149
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 92-148 2.91e-24

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 93.08  E-value: 2.91e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 21361183     92 QRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWR 148
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 93-151 2.95e-24

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 93.46  E-value: 2.95e-24
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 21361183  93 RRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRE 151
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
40-149 1.68e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 61.68  E-value: 1.68e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361183  40 APGQPRSLDSSKHRLEVHTISdTSSPEAAEKDKSQQGKNEDV-GAEDPSKKKRQRRQRThfTSQQLQELEATFQRNRYPD 118
Cdd:COG5576   1 SPVQPMQPLSALESQRMPQIR-TIKTTKNKREVEAADSEMKLeRKQDGSSPPKSKRRRT--TDEQLMVLEREFEINPYPS 77

                        90       100       110
                ....*....|....*....|....*....|.
gi 21361183 119 MSTREEIAVWTNLTEARVRVWFKNRRAKWRK 149
Cdd:COG5576  78 SITRIKLSLLLNMPPKSVQIWFQNKRAKEKK 108
OAR pfam03826
OAR motif; The entry represents the OAR motif.
 282-299 2.17e-05

OAR motif; The entry represents the OAR motif.


Pssm-ID: 461067  Cd Length: 19  Bit Score: 40.47  E-value: 2.17e-05
                          10
                  ....*....|....*...
gi 21361183   282 DTCNSSLASLRLKAKQHS 299
Cdd:pfam03826   1 DRRSSSIASLRLKAKEHS 18
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
93-149 2.52e-29

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 106.43  E-value: 2.52e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 21361183    93 RRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRK 149
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 92-148 2.91e-24

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 93.08  E-value: 2.91e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 21361183     92 QRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWR 148
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 93-151 2.95e-24

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 93.46  E-value: 2.95e-24
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 21361183  93 RRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRE 151
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
40-149 1.68e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 61.68  E-value: 1.68e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361183  40 APGQPRSLDSSKHRLEVHTISdTSSPEAAEKDKSQQGKNEDV-GAEDPSKKKRQRRQRThfTSQQLQELEATFQRNRYPD 118
Cdd:COG5576   1 SPVQPMQPLSALESQRMPQIR-TIKTTKNKREVEAADSEMKLeRKQDGSSPPKSKRRRT--TDEQLMVLEREFEINPYPS 77

                        90       100       110
                ....*....|....*....|....*....|.
gi 21361183 119 MSTREEIAVWTNLTEARVRVWFKNRRAKWRK 149
Cdd:COG5576  78 SITRIKLSLLLNMPPKSVQIWFQNKRAKEKK 108
OAR pfam03826
OAR motif; The entry represents the OAR motif.
 282-299 2.17e-05

OAR motif; The entry represents the OAR motif.


Pssm-ID: 461067  Cd Length: 19  Bit Score: 40.47  E-value: 2.17e-05
                          10
                  ....*....|....*...
gi 21361183   282 DTCNSSLASLRLKAKQHS 299
Cdd:pfam03826   1 DRRSSSIASLRLKAKEHS 18
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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