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Conserved domains on  [gi|66529294|ref|NP_000296|]
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serum paraoxonase/arylesterase 2 isoform 1 [Homo sapiens]

Protein Classification

strictosidine synthase family protein( domain architecture ID 10484254)

strictosidine synthase family protein with similarity to strictosidine synthase that catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arylesterase pfam01731
Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1. ...
 167-252 7.81e-48

Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1.2. These enzymes hydrolyse organophosphorus esters such as paraoxon and are found in the liver and blood. They confer resistance to organophosphate toxicity. Human arylesterase (PON1) is associated with HDL and may protect against LDL oxidation.


:

Pssm-ID: 334656  Cd Length: 86  Bit Score: 156.47  E-value: 7.81e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66529294   167 NDITAVGPAHFYATNDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADILAHEIHV 246
Cdd:pfam01731   1 NDIVAVGPDSFYATNDHYFGDPFLQNLEMYLGLIWTGVVYYSPSEVKVVASGFSFANGINYSPDKKYIYVASSLRHSIHV 80


                  ....*.
gi 66529294   247 LEKHTN 252
Cdd:pfam01731  81 MKKHAN 86
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 106-296 3.05e-12

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


:

Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 66.07  E-value: 3.05e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66529294 106 FDLASFNPHGIstFIDNDDTvyLFVVNHpefknTVEIFKFEEAENSLLHLKTVKHELLPSVNDItAVGPA-HFYATNDHY 184
Cdd:COG3386  44 FAEPSGRPNGL--AFDPDGR--LLVADH-----GRGLVRFDPADGEVTVLADEYGKPLNRPNDG-VVDPDgRLYFTDMGE 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66529294 185 FSDPflkyletylnlhwANVVYYSPN-EVKVVAEGFDSANGINISPDDKYIYVADILAHEIHVLEKHTNMNLTQLKVL-- 261
Cdd:COG3386 114 YLPT-------------GALYRVDPDgSLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRIYRFDLDADGTLGNRRVFad 180

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 66529294 262 --ELDTLVDNLSIDpSSGDIWVgCHPNGQKLFVYDPN 296
Cdd:COG3386 181 lpDGPGGPDGLAVD-ADGNLWV-ALWGGGGVVRFDPD 215
 
Name Accession Description Interval E-value
Arylesterase pfam01731
Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1. ...
 167-252 7.81e-48

Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1.2. These enzymes hydrolyse organophosphorus esters such as paraoxon and are found in the liver and blood. They confer resistance to organophosphate toxicity. Human arylesterase (PON1) is associated with HDL and may protect against LDL oxidation.


Pssm-ID: 334656  Cd Length: 86  Bit Score: 156.47  E-value: 7.81e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66529294   167 NDITAVGPAHFYATNDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADILAHEIHV 246
Cdd:pfam01731   1 NDIVAVGPDSFYATNDHYFGDPFLQNLEMYLGLIWTGVVYYSPSEVKVVASGFSFANGINYSPDKKYIYVASSLRHSIHV 80


                  ....*.
gi 66529294   247 LEKHTN 252
Cdd:pfam01731  81 MKKHAN 86
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 106-296 3.05e-12

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 66.07  E-value: 3.05e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66529294 106 FDLASFNPHGIstFIDNDDTvyLFVVNHpefknTVEIFKFEEAENSLLHLKTVKHELLPSVNDItAVGPA-HFYATNDHY 184
Cdd:COG3386  44 FAEPSGRPNGL--AFDPDGR--LLVADH-----GRGLVRFDPADGEVTVLADEYGKPLNRPNDG-VVDPDgRLYFTDMGE 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66529294 185 FSDPflkyletylnlhwANVVYYSPN-EVKVVAEGFDSANGINISPDDKYIYVADILAHEIHVLEKHTNMNLTQLKVL-- 261
Cdd:COG3386 114 YLPT-------------GALYRVDPDgSLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRIYRFDLDADGTLGNRRVFad 180

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 66529294 262 --ELDTLVDNLSIDpSSGDIWVgCHPNGQKLFVYDPN 296
Cdd:COG3386 181 lpDGPGGPDGLAVD-ADGNLWV-ALWGGGGVVRFDPD 215
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 204-249 5.95e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 37.95  E-value: 5.95e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 66529294 204 VVYYSPNEVKV----VAEGFDSANGINISPDDKYIYVADILAHEIHVLEK 249
Cdd:cd14962  80 VFVFDRDGKFLraigAGALFKRPTGIAVDPAGKRLYVVDTLAHKVKVFDL 129
 
Name Accession Description Interval E-value
Arylesterase pfam01731
Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1. ...
 167-252 7.81e-48

Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1.2. These enzymes hydrolyse organophosphorus esters such as paraoxon and are found in the liver and blood. They confer resistance to organophosphate toxicity. Human arylesterase (PON1) is associated with HDL and may protect against LDL oxidation.


Pssm-ID: 334656  Cd Length: 86  Bit Score: 156.47  E-value: 7.81e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66529294   167 NDITAVGPAHFYATNDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADILAHEIHV 246
Cdd:pfam01731   1 NDIVAVGPDSFYATNDHYFGDPFLQNLEMYLGLIWTGVVYYSPSEVKVVASGFSFANGINYSPDKKYIYVASSLRHSIHV 80


                  ....*.
gi 66529294   247 LEKHTN 252
Cdd:pfam01731  81 MKKHAN 86
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 106-296 3.05e-12

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 66.07  E-value: 3.05e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66529294 106 FDLASFNPHGIstFIDNDDTvyLFVVNHpefknTVEIFKFEEAENSLLHLKTVKHELLPSVNDItAVGPA-HFYATNDHY 184
Cdd:COG3386  44 FAEPSGRPNGL--AFDPDGR--LLVADH-----GRGLVRFDPADGEVTVLADEYGKPLNRPNDG-VVDPDgRLYFTDMGE 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66529294 185 FSDPflkyletylnlhwANVVYYSPN-EVKVVAEGFDSANGINISPDDKYIYVADILAHEIHVLEKHTNMNLTQLKVL-- 261
Cdd:COG3386 114 YLPT-------------GALYRVDPDgSLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRIYRFDLDADGTLGNRRVFad 180

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 66529294 262 --ELDTLVDNLSIDpSSGDIWVgCHPNGQKLFVYDPN 296
Cdd:COG3386 181 lpDGPGGPDGLAVD-ADGNLWV-ALWGGGGVVRFDPD 215
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 167-296 3.43e-06

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 47.64  E-value: 3.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66529294   167 NDItAVGPA-HFYATNDHYFSDPflkyletylNLHWANVVYYSPN-EVKVVAEGFDSANGINISPDDKYIYVADILAHEI 244
Cdd:pfam08450  89 NDG-KVDPDgRFWFGTMGDDEAP---------GGDPGALYRLDPDgKLTRVLDGLTISNGLAWSPDGRTLYFADSPARKI 158

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 66529294   245 HVLE-KHTNMNLTQLKVL----ELDTLVDNLSIDpSSGDIWVgCHPNGQKLFVYDPN 296
Cdd:pfam08450 159 WAYDyDLDGGLISNRRVFadfkPGLGRPDGMAVD-AEGNVWV-ARWGGGKVVRFDPD 213
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
210-297 8.65e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.45  E-value: 8.65e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66529294 210 NEVKVVAEGfDSANGINISPDDKYIYVADILAHEIHVLekhtnmnltqlkVLELDT----LVDNLSIDPSSGDIWVgcHP 285
Cdd:COG3391 143 KVVATIPVG-AGPHGIAVDPDGKRLYVANSGSNTVSVI------------VSVIDTatgkVVATIPVGGGPVGVAV--SP 207

                        90
                ....*....|..
gi 66529294 286 NGQKLFVYDPNN 297
Cdd:COG3391 208 DGRRLYVANRGS 219
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 204-249 5.95e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 37.95  E-value: 5.95e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 66529294 204 VVYYSPNEVKV----VAEGFDSANGINISPDDKYIYVADILAHEIHVLEK 249
Cdd:cd14962  80 VFVFDRDGKFLraigAGALFKRPTGIAVDPAGKRLYVVDTLAHKVKVFDL 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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