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Conserved domains on  [gi|106067657|ref|NP_000224|]
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lutropin-choriogonadotropic hormone receptor precursor [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 13572202)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
360-634 0e+00

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


:

Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 541.76  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 360 DFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGC 439
Cdd:cd15359    1 DFLRVLIWFINILAIAGNLIVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKSQYYNHAIDWQTGSGC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 STAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDV 519
Cdd:cd15359   81 STAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKLRLRHAILIMLGGWVFSLLIAVLPLVGVSNYMKVSICLPMDI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 520 ETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLI 599
Cdd:cd15359  161 ETLLSQAYILLILVLNVIAFLVICACYIKIYLAVQNPELVAKNKDTKIAKRMAILIFTDFTCMAPISFFAISAAFKVPLI 240
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 106067657 600 TVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15359  241 TVTNSKILLVLFYPINSCANPFLYAIFTKAFRRDF 275
LRR_5 super family cl37855
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
62-198 1.94e-08

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


The actual alignment was detected with superfamily member pfam13306:

Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 53.32  E-value: 1.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657   62 KVIPSQAFRGLNeVIKIEISqiDSLERIEANAFDNLLNLSEILIQNtkNLRYIEPGAFINLPrLKYLSIcNTGIRKFPDv 141
Cdd:pfam13306   1 TSIGSYAFYNCS-LTSITIP--SSLTSIGEYAFSNCTSLKSITLPS--SLTSIGSYAFYNCS-LTSITI-PSSLTSIGE- 72
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 106067657  142 tKVFSSESNfILEICDNLHITTIPGNAFQGMNNESVTLklyGNGFEEVQSHAFNGTT 198
Cdd:pfam13306  73 -YAFSNCSN-LKSITLPSNLTSIGSYAFSNCSLKSITI---PSSVTTIGSYAFSNCS 124
 
Name Accession Description Interval E-value
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
360-634 0e+00

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 541.76  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 360 DFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGC 439
Cdd:cd15359    1 DFLRVLIWFINILAIAGNLIVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKSQYYNHAIDWQTGSGC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 STAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDV 519
Cdd:cd15359   81 STAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKLRLRHAILIMLGGWVFSLLIAVLPLVGVSNYMKVSICLPMDI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 520 ETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLI 599
Cdd:cd15359  161 ETLLSQAYILLILVLNVIAFLVICACYIKIYLAVQNPELVAKNKDTKIAKRMAILIFTDFTCMAPISFFAISAAFKVPLI 240
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 106067657 600 TVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15359  241 TVTNSKILLVLFYPINSCANPFLYAIFTKAFRRDF 275
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
376-623 8.03e-40

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 147.06  E-value: 8.03e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657  376 GNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVdsqtkgqYYNHAIDWQTGS-GCSTAGFFTVFASELSV 454
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLV-------YYLNHGDWPFGSaLCKIVGALFVVNGYASI 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657  455 YTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMK----VSICFPMDVETTLSQVYILt 530
Cdd:pfam00001  74 LLLTAISIDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVpegnVTVCFIDFPEDLSKPVSYT- 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657  531 iLILNVVAFFI----ICACYIKIYFAVRNPELM-----ATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAF----KVP 597
Cdd:pfam00001 153 -LLISVLGFLLpllvILVCYTLIIRTLRKSASKqksseRTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLaldcELS 231
                         250       260
                  ....*....|....*....|....*.
gi 106067657  598 LITVTNSKVLLVLFYpINSCANPFLY 623
Cdd:pfam00001 232 RLLDKALSVTLWLAY-VNSCLNPIIY 256
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
62-198 1.94e-08

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 53.32  E-value: 1.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657   62 KVIPSQAFRGLNeVIKIEISqiDSLERIEANAFDNLLNLSEILIQNtkNLRYIEPGAFINLPrLKYLSIcNTGIRKFPDv 141
Cdd:pfam13306   1 TSIGSYAFYNCS-LTSITIP--SSLTSIGEYAFSNCTSLKSITLPS--SLTSIGSYAFYNCS-LTSITI-PSSLTSIGE- 72
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 106067657  142 tKVFSSESNfILEICDNLHITTIPGNAFQGMNNESVTLklyGNGFEEVQSHAFNGTT 198
Cdd:pfam13306  73 -YAFSNCSN-LKSITLPSNLTSIGSYAFSNCSLKSITI---PSSVTTIGSYAFSNCS 124
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
348-630 2.55e-05

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 47.08  E-value: 2.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 348 DAFNPCEDIMGYD----FLRVLIWLINILAIMGNMTVLFVLltSRYKL-TVPRFLMCNLSFADfcmglyLLLIASVDSQT 422
Cdd:PHA03087  25 EDYADCDLNIGYDtnstILIVVYSTIFFFGLVGNIIVIYVL--TKTKIkTPMDIYLLNLAVSD------LLFVMTLPFQI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 423 kgqYYNHAIDWQTGS-GCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSsLIAMLP 501
Cdd:PHA03087  97 ---YYYILFQWSFGEfACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIIS-IIETTP 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 502 LVGVSNYMKV---SICFPMDVETTLSQVYILTILIlNVVAFFI----ICACYIKIYFAVRNpelMATNKDTKIAKKMAIL 574
Cdd:PHA03087 173 ILFVYTTKKDhetLICCMFYNNKTMNWKLFINFEI-NIIGMLIpltiLLYCYSKILITLKG---INKSKKNKKAIKLVLI 248
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 106067657 575 IFTDFT-CMAP--ISFFAISA---AFKVPLITVtnSKVLLVLFYP-----INSCANPFLYAIFTKTF 630
Cdd:PHA03087 249 IVILFViFWLPfnVSVFVYSLhilHFKSGCKAV--KYIQYALHVTeiislSHCCINPLIYAFVSEFF 313
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-274 3.69e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.30  E-value: 3.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657  51 LTRLSLAYLPVKVIPSqAFRGLNEVIKIEIS--QIDSLerieANAFDNLLNLSEILIQNTKnLRYIePGAFINLPRLKYL 128
Cdd:COG4886  161 LKSLDLSNNQLTDLPE-ELGNLTNLKELDLSnnQITDL----PEPLGNLTNLEELDLSGNQ-LTDL-PEPLANLTNLETL 233
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 129 SICNTGIRKFPDVTKvFSSESNFILeicDNLHITTIPGNAfqGMNNESvTLKLYGNGFEEVQ-SHAFNGTTLTSLELKEN 207
Cdd:COG4886  234 DLSNNQLTDLPELGN-LTNLEELDL---SNNQLTDLPPLA--NLTNLK-TLDLSNNQLTDLKlKELELLLGLNSLLLLLL 306
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 106067657 208 VHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRLIATSSYSLKKLPSRETFVNLLEATLT 274
Cdd:COG4886  307 LLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373
 
Name Accession Description Interval E-value
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
360-634 0e+00

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 541.76  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 360 DFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGC 439
Cdd:cd15359    1 DFLRVLIWFINILAIAGNLIVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKSQYYNHAIDWQTGSGC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 STAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDV 519
Cdd:cd15359   81 STAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKLRLRHAILIMLGGWVFSLLIAVLPLVGVSNYMKVSICLPMDI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 520 ETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLI 599
Cdd:cd15359  161 ETLLSQAYILLILVLNVIAFLVICACYIKIYLAVQNPELVAKNKDTKIAKRMAILIFTDFTCMAPISFFAISAAFKVPLI 240
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 106067657 600 TVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15359  241 TVTNSKILLVLFYPINSCANPFLYAIFTKAFRRDF 275
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
360-634 4.05e-174

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 497.89  E-value: 4.05e-174
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 360 DFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGC 439
Cdd:cd15136    1 WWLRIGVWFVFLLALVGNIIVLLVLLTSRTKLTVPRFLMCNLAFADFCMGIYLGLLAIVDAKTLGEYYNYAIDWQTGAGC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 STAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDV 519
Cdd:cd15136   81 KTAGFLAVFSSELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMALLPLVGVSSYSKTSICLPFET 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 520 ETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLI 599
Cdd:cd15136  161 ETPVSKAYVIFLLLFNGLAFLIICGCYIKIYLSVRGSGRAANSNDTRIAKRMALLVFTDFLCWAPIAFFGLTAAFGLPLI 240
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 106067657 600 TVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15136  241 SVSNAKILLVFFYPLNSCANPFLYAIFTKQFRRDC 275
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
360-634 9.89e-164

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 471.65  E-value: 9.89e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 360 DFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGC 439
Cdd:cd15360    1 NILRVLIWFINILAITGNIVVLAILLTSQYKLTVPRFLMCNLAFADLCMGIYLLLIASVDIRTKSQYYNYAIDWQTGAGC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 STAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDV 519
Cdd:cd15360   81 AAAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKVRLRHAAVIMVGGWIFAFTVALLPIFGISSYMKVSICLPMDI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 520 ETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLI 599
Cdd:cd15360  161 ESPLSQAYIIFILVLNVLAFLIICACYIKIYLTVRNPNFVSSNSDTKIAKRMAVLIFTDFLCMAPISFFAISASLKVPLI 240
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 106067657 600 TVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15360  241 TVSKSKILLVLFYPINSCANPFLYAIFTKTFRRDF 275
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
361-633 7.40e-160

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 461.68  E-value: 7.40e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCS 440
Cdd:cd15964    2 FLRIVVWFVNLLAILGNVFVLLILLTSHYKLTVPRFLMCNLAFADFCMGIYLLLIASVDLHTRSEYYNHAIDWQTGPGCN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 441 TAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVE 520
Cdd:cd15964   82 TAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHASAIMLGGWVFCFLLALLPLVGVSSYAKVSICLPMDTE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 521 TTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLIT 600
Cdd:cd15964  162 TPLAQAYIVFVLMLNIIAFVIICACYIKIYITVRNPQYKSGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLIT 241
                        250       260       270
                 ....*....|....*....|....*....|...
gi 106067657 601 VTNSKVLLVLFYPINSCANPFLYAIFTKTFQRD 633
Cdd:cd15964  242 VSNSKILLVLFYPLNSCANPFLYAIFTKAFRRD 274
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
362-634 3.72e-88

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 277.58  E-value: 3.72e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 362 LRVLIWLINILAIMGNMTVLFVLLTSRYKL-TVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCS 440
Cdd:cd14980    3 LRIFIWIIGILALIGNILVIIWHISSKKKKkKVPKLLIINLAIADFLMGIYLLIIAIADQYYRGRYAQYSEEWLRSPPCL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 441 TAGFFTVFASELSVYTLTVITLERWHTITYAIHLdQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSN-------YMKVSI 513
Cdd:cd14980   83 LACFLVSLSSLMSVLMMLLITLDRYICIVYPFSN-KRLSYKSAKIILILGWLFSIIFAAIPILYSINqpgdnrlYGYSSI 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 514 CFPMDVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMA----TNKDTKIAKKMAILIFTDFTCMAPISFFA 589
Cdd:cd14980  162 CMPSNVSNPYYRGWLIAYLLLTFIAWIIICILYILIFISVRKSRKSArrssSKRDKRIAIRLALILITDLICWLPYYIVI 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 106067657 590 ISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd14980  242 FSGLLTSTEIDIHVLQFIAILALPLNSAINPYLYTLTTPTFKRDF 286
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
361-632 4.60e-56

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 192.80  E-value: 4.60e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCS 440
Cdd:cd15137    2 VLRVFIWVVGIIALLGNLFVLIWRLKYKEENKVHSFLIKNLAIADFLMGVYLLIIASVDLYYRGVYIKHDEEWRSSWLCT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 441 TAGFFTVFASELSVYTLTVITLERWHTITYAIHlDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSN----YMKVSICFP 516
Cdd:cd15137   82 FAGFLATLSSEVSVLILTLITLDRFICIVFPFS-GRRLGLRRAIIVLACIWLIGLLLAVLPLLPWDYfgnfYGRSGVCLP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 517 M--DVETTLSQVY-ILTILILNVVAFFIICACYIKIYFAVR----NPELMATNKDTKIAKKMAILIFTDFTCMAPISFFA 589
Cdd:cd15137  161 LhiTDERPAGWEYsVFVFLGLNFLAFVFILLSYIAMFISIRrtrkAAASRKSKRDMAVAKRFFLIVLTDFLCWIPIIVIG 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 106067657 590 ISAAFKVPlITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQR 632
Cdd:cd15137  241 ILALSGVP-IPGEVYAWVAVFVLPINSALNPILYTLSTPKFRK 282
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
376-623 8.03e-40

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 147.06  E-value: 8.03e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657  376 GNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVdsqtkgqYYNHAIDWQTGS-GCSTAGFFTVFASELSV 454
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLV-------YYLNHGDWPFGSaLCKIVGALFVVNGYASI 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657  455 YTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMK----VSICFPMDVETTLSQVYILt 530
Cdd:pfam00001  74 LLLTAISIDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVpegnVTVCFIDFPEDLSKPVSYT- 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657  531 iLILNVVAFFI----ICACYIKIYFAVRNPELM-----ATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAF----KVP 597
Cdd:pfam00001 153 -LLISVLGFLLpllvILVCYTLIIRTLRKSASKqksseRTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLaldcELS 231
                         250       260
                  ....*....|....*....|....*.
gi 106067657  598 LITVTNSKVLLVLFYpINSCANPFLY 623
Cdd:pfam00001 232 RLLDKALSVTLWLAY-VNSCLNPIIY 256
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
364-626 1.22e-39

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 147.05  E-value: 1.22e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIdwqtgsgCSTAG 443
Cdd:cd00637    3 VLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDAL-------CKLLG 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 444 FFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVG--VSNYMKVSICFPMDVET 521
Cdd:cd00637   76 FLQSVSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGwgVYDYGGYCCCCLCWPDL 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 522 TLSQVYILTILILNVVA-FFIICACYIKIYFAVRNPELMATN------------KDTKIAKKMAILIFTDFTCMAPISFF 588
Cdd:cd00637  156 TLSKAYTIFLFVLLFLLpLLVIIVCYVRIFRKLRRHRRRIRSsssnssrrrrrrRERKVTKTLLIVVVVFLLCWLPYFIL 235
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 106067657 589 AISAAFKVPLITVTNS-KVLLVLFYPINSCANPFLYAIF 626
Cdd:cd00637  236 LLLDVFGPDPSPLPRIlYFLALLLAYLNSAINPIIYAFF 274
7tmA_LRR_GPR cd15138
orphan leucine-rich repeat-containing G protein-coupled receptors, member of the class A ...
362-634 2.83e-38

orphan leucine-rich repeat-containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4), 5 (LGR5), and 6 (LGR6). These receptors contain a subfamily of receptors related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The RSPO proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320266  Cd Length: 274  Bit Score: 143.46  E-value: 2.83e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 362 LRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCST 441
Cdd:cd15138    3 IRLTVWFIFLLALFCNLLVILTVFASCTSLPPSKLFIGLIAVSNLLTGISTGILAFVDAVTFGRFAEFGAWWETGSGCKV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 442 AGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVET 521
Cdd:cd15138   83 AGFLAVFSSESSVFLLTLAAVERSLSVKDIMKNGKSNHLKSFRVAALLCFLLATVAAAFPLFHRGEYGASPLCLPFPTGE 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 522 TLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMAtNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITV 601
Cdd:cd15138  163 PPSLGFTVALVLLNSLCFLLMAVAYTKLYCNLEKGDLEE-NWDCSMVKHVAWLIFTNCILFCPVAFLSFASLITLISISP 241
                        250       260       270
                 ....*....|....*....|....*....|...
gi 106067657 602 TNSKVLLVLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15138  242 EIMKSVLLVVFPLPACLNPLLYVLFNPHFKEDL 274
7tmA_LGR4 cd15361
leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of ...
362-634 6.68e-35

leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor Lgr4 (formerly known as Gpr48), together with its close family members LGR5 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320483  Cd Length: 274  Bit Score: 133.83  E-value: 6.68e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 362 LRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCST 441
Cdd:cd15361    3 IRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFVGLIAVSNLFMGVYTGILTFLDTVSWGRFAEFGIWWETGSGCKV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 442 AGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVET 521
Cdd:cd15361   83 AGFLAVFSSESAIFLLMLAAVERSLSAKDIMKKGKSNRLRQFQIAALLAFLVATAAGCLPLFHGGEYSASPLCLPFPTGE 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 522 TLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELmATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITV 601
Cdd:cd15361  163 TPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDL-SENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISP 241
                        250       260       270
                 ....*....|....*....|....*....|...
gi 106067657 602 TNSKVLLVLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15361  242 EIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDW 274
7tmA_LGR5 cd15363
leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of ...
361-633 1.54e-33

leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor LGR6, together with its family members LGR4 and LGR5, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR6 serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages, whereas LGR5 is a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320485  Cd Length: 274  Bit Score: 129.97  E-value: 1.54e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCS 440
Cdd:cd15363    2 LIRIGVWTIAVLALVCNALVTATVFRSPLYISSIKLLIGLIAIVNMLMGVSSAVLAGVDAFTFGSFAQHGAWWESGVGCQ 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 441 TAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVE 520
Cdd:cd15363   82 ITGFLSIFASESSVFLLTLAALERGFSVKCSTKFETKSPFLSLKAIILLCFLLALTIAVIPLLGGSEYGASPLCLPLPFG 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 521 TTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATnKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLIT 600
Cdd:cd15363  162 EPSAMGYMVALVLLNSLCFLVMTIAYTKLYCSLEKGELENI-WDCSMVKHIALLLFTNCILYCPVAFLSFSSLLNLTFIS 240
                        250       260       270
                 ....*....|....*....|....*....|...
gi 106067657 601 VTNSKVLLVLFYPINSCANPFLYAIFTKTFQRD 633
Cdd:cd15363  241 PEVIKFILLVIVPLPACLNPLLYILFNPHFKED 273
7tmA_LGR6 cd15362
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane ...
362-634 3.43e-32

leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs; The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320484  Cd Length: 276  Bit Score: 126.06  E-value: 3.43e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 362 LRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCST 441
Cdd:cd15362    3 VRLGVWAIVLVSVLCNGLVILTVFASPGYLSPVKFVIGSIAGANLLTGICTGTLALVDALTFGQFAKYGARWETGLGCRA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 442 AGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVET 521
Cdd:cd15362   83 TGFLSVFASEASILLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAAALCCLALSLTAAALPLFSVGEYGASPLCLPSPLPD 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 522 TLSQV--YILTILILNVVAFFIICACYIKIYFAVRNPELMATnKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLI 599
Cdd:cd15362  163 GKPSTlgFTVALIMMNTLCFLVITGTYIKLYCDLLKGEFDAI-WDCAMIKHVAWLIFTNCLLYCPVAFLTFSSLLNLFPI 241
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 106067657 600 TVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15362  242 SPEVIKSVLLVVLPLPACLNPLLYLLFNPHFRDDL 276
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
364-634 7.90e-31

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 121.52  E-value: 7.90e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDsqtkgQYYNHaidWQTGSG-CSTA 442
Cdd:cd14967    4 VFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVY-----TLLGY---WPFGPVlCRFW 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 443 GFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMdVETT 522
Cdd:cd14967   76 IALDVLCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCE-CEFT 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 523 LSQVYILTILILN-VVAFFIICACYIKIYFAVRnpelmatnKDTKIAKKMAILIFTDFTCMAP-ISFFAISAAFKVPLIT 600
Cdd:cd14967  155 PNKIYVLVSSVISfFIPLLIMIVLYARIFRVAR--------RELKAAKTLAIIVGAFLLCWLPfFIIYLVSAFCPPDCVP 226
                        250       260       270
                 ....*....|....*....|....*....|....
gi 106067657 601 VTNSKVLLVLFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd14967  227 PILYAVFFWLGY-LNSALNPIIYALFNRDFRRAF 259
7tmA_RXFP1_LGR7 cd15965
relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G ...
362-631 9.11e-30

relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. Relaxin is the endogenous ligand for RXFP1, which has a large extracellular N-terminal domain containing 10 leucine-rich repeats and a unique low-density lipoprotein type A (LDLa) module which is necessary for receptor activation. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP and nitric oxide. RXFP1 is expressed in various tissues including uterus, ovary, placenta, cerebral cortex, heart, lung and kidney, among others.


Pssm-ID: 320631 [Multi-domain]  Cd Length: 287  Bit Score: 119.59  E-value: 9.11e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 362 LRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCST 441
Cdd:cd15965    3 QRVFVWVVSAVTCFGNIFVICMRPYIRSENKLHAMSIISLCCADCLMGIYLFVIGAFDLKYRGEYNKHAQLWMDSTQCQL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 442 AGFFTVFASELSVYTLTVITLERWHTITYAIHLdQKLRLRHAILIMLGGWLFSSLIAMLPLVG---VSNYMKVS-ICFPM 517
Cdd:cd15965   83 VGSLAILSTEVSVLLLTYLTLEKYICIVYPFRC-LTPGKCRTITILILIWIIGFIIAFIPLSNkefFRNYYGTNgVCFPL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 518 ---DVETTLSQVYILTILI-LNVVAFFIICACYIKIYFAVRNPELMAT------NKDTKIAKKMAILIFTDFTCMAPISF 587
Cdd:cd15965  162 hseQPESTGAQIYSVVIFLgLNLAAFIIIVFSYGSMFYSIHQTAIMATeisnhiKKEMTLAKRFFFIVFTDALCWIPIFI 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 106067657 588 FAISAAFKVPLI-TVTNSKVLLVLfyPINSCANPFLYAIFTKTFQ 631
Cdd:cd15965  242 LKLLSLLQVEIPgTISSWVVIFIL--PINSALNPILYTLTTRPFK 284
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
364-632 2.59e-28

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 115.00  E-value: 2.59e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGL--YLLLIASvdsqtkgqyyNHAIDWQTGS-GCS 440
Cdd:cd14969    5 VYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVvgYPLSFYS----------NLSGRWSFGDpGCV 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 441 TAGFFTVFASELSVYTLTVITLERWHTITYAIhLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYM----KVSiCFP 516
Cdd:cd14969   75 IYGFAVTFLGLVSISTLAALAFERYLVIVRPL-KAFRLSKRRALILIAFIWLYGLFWALPPLFGWSSYVpeggGTS-CSV 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 517 -MDVETTLSQVYILTILILN-VVAFFIICACYIKIYFAVRNPELMATN------------KDTKIAKKMAILIFTDFTCM 582
Cdd:cd14969  153 dWYSKDPNSLSYIVSLFVFCfFLPLAIIIFCYYKIYRTLRKMSKRAARrknsaitkrtkkAEKKVAKMVLVMIVAFLIAW 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 106067657 583 APISFFAISAAF----KVPLITVTnskvLLVLFYPINSCANPFLYAIFTKTFQR 632
Cdd:cd14969  233 TPYAVVSLYVSFggesTIPPLLAT----IPALFAKSSTIYNPIIYVFMNKQFRR 282
7tmA_RXFP2_LGR8 cd15966
relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G ...
362-631 5.59e-26

relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural similarity, but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. INSL3 is the endogenous ligand for RXFP2, which couples to the G(s) protein to increase intracellular cAMP levels, but also to the GoB protein to decrease cAMP formation. RXFP2 (or LGR8) is expressed in various tissues including the brain, kidney, muscle, testis, thyroid, uterus, and peripheral blood cells, among others.


Pssm-ID: 320632  Cd Length: 287  Bit Score: 108.33  E-value: 5.59e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 362 LRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCST 441
Cdd:cd15966    3 LRVFVWVMAFITCFGNLFVIGMRSFIRAENKTHAMCIKILCCADCLMGVYLFFVGIFDVKYRGEYNKYALLWMESLQCRI 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 442 AGFFTVFASELSVYTLTVITLERWHTITYAI-HLDQKLRLRHAILIMLggWLFSSLIAMLPLVGV----SNYMKVSICFP 516
Cdd:cd15966   83 IGFLAMLSTEVSVLLLTYLTLEKYLVIVFPFsNIRPGKCQTLIILISI--WLVGFIIAVIPFWNEdffgNYYGKNGVCFP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 517 M---DVETTLSQVYILTILI-LNVVAFFIICACYIKIYFAVRNPELMAT------NKDTKIAKKMAILIFTDFTCMAPIS 586
Cdd:cd15966  161 LhsdQTEKIGAKGYSTGIFLgLNLLAFIIIVFSYSSMFCSIQKTGLQTTevrshiHRDVAVANRFFFIVFSDAICWIPIF 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 106067657 587 FFAISAAFKVPLI-TVTNSKVLLVLfyPINSCANPFLYAIFTKTFQ 631
Cdd:cd15966  241 LLKILSLFQVEIPgTITSWIVIFIL--PINSALNPILYTLTTSFFK 284
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
364-633 4.08e-25

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 105.82  E-value: 4.08e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGL--YLLLIASVdsqtkgqyYNHAidWQTGS-GCS 440
Cdd:cd15074    5 IYLTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVfgYPLAIISA--------FAHR--WLFGDiGCV 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 441 TAGFFTVFASELSVYTLTVITLERWHTITYAiHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNY------MKVSIC 514
Cdd:cd15074   75 FYGFCGFLFGCCSINTLTAISIYRYLKICHP-PYGPKLSRRHVCIVIVAIWLYALFWAVAPLVGWGSYgpepfgTSCSID 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 515 FPMDVETTLSQVYILTILILN-VVAFFIICACYIKIYFAVRNPELMATNKDTKIAK---------KMAILIFTDF----T 580
Cdd:cd15074  154 WTGASASVGGMSYIISIFIFCyLLPVLIIVFSYVKIIRKVKSSRKRVAGFDSRSKRqhkierkvtKVAVLICAGFliawT 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 106067657 581 CMAPISFFAI-SAAFKVPLITvtnsKVLLVLFYPINSCANPFLYAIFTKTFQRD 633
Cdd:cd15074  234 PYAVVSMWSAfGSPDSVPILA----SILPALFAKSSCMYNPIIYLLFSSKFRQD 283
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
368-634 7.49e-22

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 96.51  E-value: 7.49e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIdwqtgsgCSTAGFF-- 445
Cdd:cd14993    9 VVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVL-------CKAVPYLqg 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 446 -TVFAselSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIaMLPLV---------GVSNYMK-VSIC 514
Cdd:cd14993   82 vSVSA---SVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIII-MLPLLvvyeleeiiSSEPGTItIYIC 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 515 FPMDVETTLSQVYILTIL-ILNVVAFFIICACYIKIYFAV--RNPELMATNKDT-----------KIAKKMAILIFTDFT 580
Cdd:cd14993  158 TEDWPSPELRKAYNVALFvVLYVLPLLIISVAYSLIGRRLwrRKPPGDRGSANStssrrilrskkKVARMLIVVVVLFAL 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 106067657 581 CMAPISFFAISAAFKVPLITVTNSKVLLVLFYP-----INSCANPFLYAIFTKTFQRDF 634
Cdd:cd14993  238 SWLPYYVLSILLDFGPLSSEESDENFLLILPFAqllgySNSAINPIIYCFMSKKFRRGF 296
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
368-634 5.58e-18

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 84.62  E-value: 5.58e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADfcmglyLLLIASVdsQTKGQYYNHAIDWQTGSG-CSTAGFFT 446
Cdd:cd14982    9 LIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALAD------LLFVLTL--PFRIYYYLNGGWWPFGDFlCRLTGLLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 447 VFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFsSLIAMLPLVGVSNYMKVS----ICFP-MDVET 521
Cdd:cd14982   81 YINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWIL-VLVASVPLLLLRSTIAKEnnstTCFEfLSEWL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 522 TLSQVYILTILILN-VVAFFIICACYIKIYFAVRNPELMATNKDTKI-AKKMAILIFTDFT-CMAPI-SFFAISAAFKVP 597
Cdd:cd14982  160 ASAAPIVLIALVVGfLIPLLIILVCYSLIIRALRRRSKQSQKSVRKRkALRMILIVLAVFLvCFLPYhVTRILYLLVRLS 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 106067657 598 LITVTNSKVLLVLFYPI-------NSCANPFLYAIFTKTFQRDF 634
Cdd:cd14982  240 FIADCSARNSLYKAYRItlclaslNSCLDPLIYYFLSKTFRKRL 283
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
364-634 6.41e-18

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 84.72  E-value: 6.41e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWL----INILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVdSQTKGQYynhaidWQTGSG- 438
Cdd:cd15392    1 VIIILmystIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFI-ALLILQY------WPFGEFm 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 439 CSTAGFFTVFASELSVYTLTVITLERWHTITYAihLDQKLRLRHAILIMLGGWLFSSLIAM-LPLV-GVSNYMKVS---- 512
Cdd:cd15392   74 CPVVNYLQAVSVFVSAFTLVAISIDRYVAIMWP--LRPRMTKRQALLLIAVIWIFALATALpIAITsRLFEDSNAScgqy 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 513 ICFPMDVETTLSQVYILTILILN-VVAFFIICACYIKIYFAV---RNPELMATNKDTKIAK------KMAILIFTDFT-C 581
Cdd:cd15392  152 ICTESWPSDTNRYIYSLVLMILQyFVPLAVLVFTYTRIGIVVwakRTPGEAENNRDQRMAEskrklvKMMITVVAIFAlC 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 106067657 582 MAPISFFAIsaafkVPLI--TVTNSKVLLVLFYPI------NSCANPFLYAIFTKTFQRDF 634
Cdd:cd15392  232 WLPLNILNL-----VGDHdeSIYSWPYIPYLWLAAhwlamsHCCYNPFIYCWMNAKFRNGF 287
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
361-625 7.86e-18

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 84.55  E-value: 7.86e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYL-LLIASVDSQTkgqyynhaidWQTGS-G 438
Cdd:cd15079    2 LLGFIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKMpIFIYNSFYEG----------WALGPlG 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 439 CSTAGFFTVFASELSVYTLTVITLERWHTITYAIhldQKLRLRH--AILIMLGGWLFSSLIAMLPL-VGVSNY----MKV 511
Cdd:cd15079   72 CQIYAFLGSLSGIGSIWTNAAIAYDRYNVIVKPL---NGNPLTRgkALLLILFIWLYALPWALLPLlFGWGRYvpegFLT 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 512 SICFPMDVETTLSQVYILTILILN-VVAFFIICACYIKIYFAVRNPELM--------------------ATNKDTKIAKK 570
Cdd:cd15079  149 SCSFDYLTRDWNTRSFVATIFVFAyVIPLIIIIYCYSFIVKAVFAHEKAlreqakkmnvvslrsnadanKQSAEIRIAKV 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 106067657 571 MAILIFTDFTCMAPISFFAISAAFKVP-LITVTNSkVLLVLFYPINSCANPFLYAI 625
Cdd:cd15079  229 ALTNVFLWFIAWTPYAVVALIGAFGNQsLLTPLVS-MIPALFAKTAACYNPIVYAI 283
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
368-634 2.79e-17

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 83.04  E-value: 2.79e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADfcmglylLLIASVdSQTKGQYYNHAIDWQTGSG-CSTAGFF- 445
Cdd:cd15203    9 LIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSD-------LLLCLV-SLPFTLIYTLTKNWPFGSIlCKLVPSLq 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 446 --TVFASELsvyTLTVITLERWHTITYaiHLDQKLRLRHAILIMLGGWLFSSLIAmLPL-----VGVSNYMKVSICFPMD 518
Cdd:cd15203   81 gvSIFVSTL---TLTAIAIDRYQLIVY--PTRPRMSKRHALLIIALIWILSLLLS-LPLaifqeLSDVPIEILPYCGYFC 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 519 VETTLSQVY-----ILTILILNVVAFFIICACYIKIYFAVRN--------PELMATNKDTKIAKK-----MAILIFTDFT 580
Cdd:cd15203  155 TESWPSSSSrliytISVLVLQFVIPLLIISFCYFRISLKLRKrvkkkrgkRTLSSRRRRSELRRKrrtnrLLIAMVVVFA 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 106067657 581 -CMAPISFFAISAAFKVPLITVTNSKVLLVLFYPI----NSCANPFLYAIFTKTFQRDF 634
Cdd:cd15203  235 vCWLPLNLFNLLRDFEPLPQIDGRHFYLIFLICHLiamsSACVNPLLYGWLNDNFRKEF 293
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
362-634 7.32e-17

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 80.86  E-value: 7.32e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 362 LRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDsQTKGQYYNHAIDWqtgsgCST 441
Cdd:cd15067    2 LGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILH-EMTGGYWLFGRDW-----CDV 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 442 AGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVgvsnYMKVSICFPMDVET 521
Cdd:cd15067   76 WHSFDVLASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISFPAIA----WWRAVDPGPSPPNQ 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 522 TLSQVYILTILILNVVAF----FIICACYIKIYfavrnpelMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFkVP 597
Cdd:cd15067  152 CLFTDDSGYLIFSSCVSFyiplVVMLFTYYRIY--------RAAAKEQKAAKTLGIVMGVFILCWLPFFVTNILIGF-CP 222
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 106067657 598 LITVTNSKVLLVLF----YpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15067  223 SNCVSNPDILFPLVtwlgY-INSGMNPIIYACSSRDFRRAF 262
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
362-632 1.47e-16

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 80.84  E-value: 1.47e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 362 LRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCM---GLYLLLIASvdsqtkgqYYNHaidWQTG-S 437
Cdd:cd15083    3 LGIFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMcilNCPLMVISS--------FSGR---WIFGkT 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 438 GCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNY----MKVSI 513
Cdd:cd15083   72 GCDMYGFSGGLFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLFGWSRYvlegLLTSC 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 514 CFPMDVETTLSQVYILTILILN-VVAFFIICACYIKIYFAVRNPELMAT------------------NKDTKIAKKMAIL 574
Cdd:cd15083  152 SFDYLSRDDANRSYVICLLIFGfVLPLLIIIYCYSFIFRAVRRHEKAMKemakrfskselsspkarrQAEVKTAKIALLL 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 106067657 575 IFTDFTCMAPISFFAISAAFKvPLITVTNSKVLL-VLFYPINSCANPFLYAIFTKTFQR 632
Cdd:cd15083  232 VLLFCLAWTPYAVVALIGQFG-YLEVLTPLATAIpAAFAKTSAIYNPVIYAFSHPKFRR 289
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
364-625 2.40e-16

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 80.06  E-value: 2.40e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADF----CMGLYLLLIASvdsqtkgqyYNHAidWQTGS-G 438
Cdd:cd15337    5 IYIAIVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFgfsaVNGFPLKTISS---------FNKK--WIWGKvA 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 439 CSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYM----KVSIC 514
Cdd:cd15337   74 CELYGFAGGIFGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFFGWGRYVpegfQTSCT 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 515 FPMDVETTLSQVYILTILILNVVA-FFIICACYIKIYFAVRN--PELMATNK----------------DTKIAKKMAILI 575
Cdd:cd15337  154 FDYLSRDLNNRLFILGLFIFGFLCpLLIIIFCYVNIIRAVRNheKEMTQTAKsgmgkdtekndarkkaEIRIAKVAIILI 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 106067657 576 FTDFTCMAP---ISFFAI--SAAFKVPLITvtnskVLLVLFYPINSCANPFLYAI 625
Cdd:cd15337  234 SLFLLSWTPyavVALLGQfgPAYWITPYVS-----ELPVMFAKASAIYNPIIYAL 283
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
361-634 7.96e-15

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 75.06  E-value: 7.96e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVdsqtkgqyYNHAIDWQTGS--- 437
Cdd:cd15064    2 LISVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAV--------YELTGRWILGQvlc 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 438 --------GCSTAgfftvfaselSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVS--N 507
Cdd:cd15064   74 diwisldvTCCTA----------SILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFGWRtpD 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 508 YMKVSICfpmdvetTLSQVYILTILIlNVVAFFI----ICACYIKIYfavrnpelMATNKDTKIAKKMAILIFTDFTCMA 583
Cdd:cd15064  144 SEDPSEC-------LISQDIGYTIFS-TFGAFYIplllMLILYWKIY--------RAAARERKAAKTLGIILGAFIVCWL 207
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 106067657 584 PisFFAISAAfkVPLITVTN-----SKVLLVLFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15064  208 P--FFLVALI--VPLCSHCWiplalKSFFLWLGY-FNSLINPLIYTFFNKDFRKAF 258
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
366-634 1.50e-14

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 74.72  E-value: 1.50e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 366 IWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTkgqyynhaIDWQTGS-GCSTAGF 444
Cdd:cd14986    7 LGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEAT--------GEWVAGDvLCRIVKY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 445 FTVFASELSVYTLTVITLERWHTITYAIH-LDQKLRLRHAILImlgGWLFSSLIAmLPLVGVSNYMKVSICFPM--DVET 521
Cdd:cd14986   79 LQVVGLFASTYILVSMSLDRYQAIVKPMSsLKPRKRARLMIVV---AWVLSFLFS-IPQLVIFVERELGDGVHQcwSSFY 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 522 TLSQ--VYI--LTILILnVVAFFIICACYIKIYFAV----RNPELMATNKDTKIAK--------------------KMAI 573
Cdd:cd14986  155 TPWQrkVYItwLATYVF-VIPLIILSYCYGRILRTIwirsRQKTDRPIAPTAMSCRsvscvssrvslisrakiktiKMTL 233
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 106067657 574 LIFTDF-TCMAPisFFAISAAFKVPLITVTNSKVLLV--LFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd14986  234 VIILAFiLCWTP--YFIVQLLDVYAGMQQLENDAYVVseTLASLNSALNPLIYGFFSSHLSFEH 295
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
360-634 1.51e-14

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 74.72  E-value: 1.51e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 360 DFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASvdsqtkgqYYNHAIDWQTGSG- 438
Cdd:cd14985    1 VVIPALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLTLPLWAT--------YTANQYDWPFGAFl 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 439 CSTAGFFTVFASELSVYTLTVITLERWHTITYAIhLDQKLRLR-HAILIMLGGWLFSSLIAMLPLV----GVSNYMKVSI 513
Cdd:cd14985   73 CKVSSYVISVNMFASIFLLTCMSVDRYLAIVHPV-ASRRLRRRrQARVTCALIWVVACLLSLPTFLlrslQAIENLNKTA 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 514 CFPMDVETTLSQVYILTILILN-VVAFFIICACYIKIYFAVRNPELMATN---KDTKIAKKMAILIFTDFTCMAPISFFA 589
Cdd:cd14985  152 CIMLYPHEAWHFGLSLELNILGfVLPLLIILTCYFHIARSLRKRYERTGKngrKRRKSLKIIFALVVAFLVCWLPFHFFK 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 106067657 590 -ISAAFKVPLITVTNSKVLLVLFYPI-------NSCANPFLYAIFTKTFQRDF 634
Cdd:cd14985  232 fLDFLAQLGAIRPCFWELFLDLGLPIatclaftNSCLNPFIYVFVDRRFRQKV 284
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
362-634 2.34e-14

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 73.98  E-value: 2.34e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 362 LRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYllliaSVDSQtkgqyYNHAI--DWQTG-SG 438
Cdd:cd15393    3 LSILYGIISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLF-----SIPFQ-----FQAALlqRWVLPrFM 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 439 CSTAGFFTVFASELSVYTLTVITLERWHTITYAihLDQKLRLRHAILIMLGGWLFSSLIAmLP---------LVGVSNYM 509
Cdd:cd15393   73 CPFCPFVQVLSVNVSVFTLTVIAVDRYRAVIHP--LKARCSKKSAKIIILIIWILALLVA-LPvalalrveeLTDKTNNG 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 510 KVSICFPMDVETTLSQVYILTILILN-VVAFFIICACYIKIYFAVR---------NPELMATNKDTKIAKKMAILIFTDF 579
Cdd:cd15393  150 VKPFCLPVGPSDDWWKIYNLYLVCVQyFVPLVIICYAYTRIAVKIWgtkapgnaqDVRDDEILKNKKKVIKMLIIVVALF 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 106067657 580 T-CMAPISFFAIsAAFKVPLITvTNSKVLLVLFYP-----INSCANPFLYAIFTKTFQRDF 634
Cdd:cd15393  230 AlCWLPLQTYNL-LNEIKPEIN-KYKYINIIWFCShwlamSNSCYNPFIYGLYNEKFKREF 288
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
368-634 3.33e-14

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 73.08  E-value: 3.33e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFcmglyLLLIASVDSQTkgqYYNHAIDWQTGSG-CSTAGFFT 446
Cdd:cd15001    8 ITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADL-----LLLVFCVPLKT---AEYFSPTWSLGAFlCKAVAYLQ 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 447 VFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVS-------NYMKVSICFPMDV 519
Cdd:cd15001   80 LLSFICSVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFGQGlvryeseNGVTVYHCQKAWP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 520 ETTLSQVYILT-ILILNVVAFFIICACYIKiyfavrnpelmatnKDTKIAKKMAILIFTDFT-CMAPISFFAISAAFKVP 597
Cdd:cd15001  160 STLYSRLYVVYlAIVIFFIPLIVMTFAYAR--------------DTRKQVIKMLISVVVLFAvCWGPLLIDNLLVSFDVI 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 106067657 598 LITVTNSKVLLVLFYPI----NSCANPFLYAIFTKTFQRDF 634
Cdd:cd15001  226 STLHTQALKYMRIAFHLlsyaNSCINPIIYAFMSKNFRSSF 266
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
368-634 4.05e-14

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 73.48  E-value: 4.05e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIAsvdsqtkgqyYNHAI-DWQTGS-------GC 439
Cdd:cd14970    9 VVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGLPFLA----------TSYLLgYWPFGEvmckivlSV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 STAGFFTvfaselSVYTLTVITLERWHTITYAI-HLDQKlRLRHAILIMLGGWLFSSLIaMLPLVGVSNYMK----VSIC 514
Cdd:cd14970   79 DAYNMFT------SIFCLTVMSVDRYLAVVHPVkSLRFR-TPRKAKLVSLCVWALSLVL-GLPVIIFARTLQeeggTISC 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 515 ---FPmDVETTLSQVYILTILILN-VVAFFIICACYIKIYF---AVRNPELM-ATNKD---TKIAKKMAILIFTDFTCMA 583
Cdd:cd14970  151 nlqWP-DPPDYWGRVFTIYTFVLGfAVPLLVITVCYSLIIRrlrSSRNLSTSgAREKRrarRKVTRLVLVVVAVFVVCWL 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 106067657 584 PISFFAI---SAAFKVPLITVTNSKVLLVLFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd14970  230 PFHVFQIvrlLIDPPETLTVVGVFLFCIALSY-ANSCLNPILYAFLDENFRKSF 282
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
368-623 7.12e-14

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 72.71  E-value: 7.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADfcmglylLLIASVDSQTKgQYYNHAIDWQTGS-GCSTAGFFT 446
Cdd:cd15390    9 VMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVAD-------LLISAFNTVFN-FTYLLYNDWPFGLfYCKFSNFVA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 447 VFASELSVYTLTVITLERWHTITYAihLDQKLRLRHAILIMLGGWLFSSLIAmLPLVGVSNYMKVS--------ICF--- 515
Cdd:cd15390   81 ITTVAASVFTLMAISIDRYIAIVHP--LRPRLSRRTTKIAIAVIWLASFLLA-LPQLLYSTTETYYyytgsertVCFiaw 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 516 PMDVETTLSQVYILTILILN-VVAFFIICACYIKIYFA-----------VRNPELMATNKdtKIAKKMAILIFTDFTCMA 583
Cdd:cd15390  158 PDGPNSLQDFVYNIVLFVVTyFLPLIIMAVAYTRVGVElwgsktigentPRQLESVRAKR--KVVKMMIVVVVIFAICWL 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 106067657 584 PISFFAISAAFKVPLITVTNSKVLLVLFYPI---NSCANPFLY 623
Cdd:cd15390  236 PYHLYFILTYLYPDINSWKYIQQIYLAIYWLamsNSMYNPIIY 278
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
364-634 7.73e-14

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 72.08  E-value: 7.73e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVdsqtkgqyYNHAIDWQTGSG-CSTA 442
Cdd:cd15060    5 ILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVA--------YFLLGKWLFGIHlCQMW 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 443 GFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVsicFPMDVETT 522
Cdd:cd15060   77 LTCDILCCTASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVPPLIGWNDWPEN---FTETTPCT 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 523 LSQ---VYILTILILNVVAFFIICACYIKIYFavrnpelmATNKDTKIAKKMAILIFTDFTCMAPisFFAISAAfkVPLI 599
Cdd:cd15060  154 LTEekgYVIYSSSGSFFIPLLIMTIVYVKIFI--------ATSKERRAARTLGIIMGVFVVCWLP--FFLMYVI--LPFC 221
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 106067657 600 TVTNSKVLLVLFYP----INSCANPFLYAIFTKTFQRDF 634
Cdd:cd15060  222 ETCSPSAKVVNFITwlgyVNSALNPVIYTIFNLDFRRAF 260
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
356-634 7.81e-14

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 72.65  E-value: 7.81e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 356 IMGYdflrVLIWLiniLAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGqyynhaidWQT 435
Cdd:cd15207    4 IVSY----SLIFL---LCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVDNILTG--------WPF 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 436 GSG-CSTAGFFTVFASELSVYTLTVITLERWHTITYAIhlDQKLRLRHAILIMLGGWLFSSLIaMLPLVGVSNY------ 508
Cdd:cd15207   69 GDVmCKLSPLVQGVSVAASVFTLVAIAVDRYRAVVHPT--EPKLTNRQAFVIIVAIWVLALAI-MIPQALVLEVkeyqff 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 509 --MKVSIC---FPMDVettLSQVYILTILILNVVA-FFIICACYIKIYFAVRNPELMAT------NKDTKIAK-----KM 571
Cdd:cd15207  146 rgQTVHICvefWPSDE---YRKAYTTSLFVLCYVApLLIIAVLYVRIGYRLWFKPVPGGgsasreAQAAVSKKkvrviKM 222
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 106067657 572 AILIFTDFT-CMAPISFFAISAAFKVplITVTNSKVLLVLFYPI-------NSCANPFLYAIFTKTFQRDF 634
Cdd:cd15207  223 LIVVVVLFAlSWLPLHTVTMLDDFGN--LSPNQREVLYVYIYPIahwlayfNSCVNPIVYGYFNRNFRKGF 291
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
369-634 2.12e-13

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 71.38  E-value: 2.12e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 369 INILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYllliaSVDSQTKGQYYNHaidWQTGSG-CSTAGFFTV 447
Cdd:cd15202   10 IIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLF-----NTPFTFVRAVNNT---WIFGLFmCHFSNFAQY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 448 FASELSVYTLTVITLERWHTITYAihLDQKLRLRHAILIMLGGWLFSSLIAM-LPLVGVSNYMKVS------ICFPMDVE 520
Cdd:cd15202   82 CSVHVSAYTLTAIAVDRYQAIMHP--LKPRISKTKAKFIIAVIWTLALAFALpHAICSKLETFKYSedivrsLCLEDWPE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 521 TTLSQVYILTILILNVVAFF---IICACYIKI---YFAVRNPELMATNKDTKIAK------KMAILIFTDFT-CMAPISF 587
Cdd:cd15202  160 RADLFWKYYDLALFILQYFLpllVISFAYARVgikLWASNMPGDATTERYFALRRkkkkviKMLMVVVVLFAlCWLPFNI 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 106067657 588 FAISAAFKVPLITVTNSKVLLVL--FYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15202  240 YVLLLSSKPDYLIKTINAVYFAFhwLAMSSTCYNPFIYCWLNERFRIEF 288
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
368-634 2.19e-13

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 71.00  E-value: 2.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVdsqtkgqyYNHAIDWQTGSG-CSTAGFFT 446
Cdd:cd15399    9 SIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLV--------YTLLDEWKFGAVlCHLVPYAQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 447 VFASELSVYTLTVITLERWHTITYaiHLDQKLRLRHAILIMLGGWLFSSLIAM-------LPLVGVSNYMKVSIC---FP 516
Cdd:cd15399   81 ALAVHVSTVTLTVIALDRHRCIVY--HLESKISKKISFLIIGLTWAASALLASplaifreYSVIEISPDFKIQACsekWP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 517 MDVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAK-----KMAILIFTDF-TCMAPISFFAI 590
Cdd:cd15399  159 NGTLNDGTIYSVSMLLIQYVLPLAIISYAYIRIWTKLKNHVSPGGGNDHYHQRrrkttKMLVCVVVVFaVSWLPFHAFQL 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 106067657 591 SAAFKVPLITVTNSKVLLVLFYPINSC---ANPFLYAIFTKTFQRDF 634
Cdd:cd15399  239 ASDIDSKVLDLKEYKLIYTIFHVIAMCstfANPLLYGWMNNNYRTAF 285
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
364-634 3.60e-13

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 70.57  E-value: 3.60e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGqyynhaidWQTGS-GCSTA 442
Cdd:cd14971    5 LFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPG--------WVFGDfMCKFV 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 443 GFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIA--MLPLVGVSNYM--KVSICFPMD 518
Cdd:cd14971   77 HYFQQVSMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAapVLALHRLRNYTpgNRTVCSEAW 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 519 VETTLSQVYIL-TILILNVVAFFIICACYIKIY-----FAVRNPELMATNKDTKIAKKMAILIFTDF-TCMAPISFFAIS 591
Cdd:cd14971  157 PSRAHRRAFALcTFLFGYLLPLLLICVCYAAMLrhlwrVAVRPVLSEGSRRAKRKVTRLVLVVVVLFaACWGPIHAILLL 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 106067657 592 AAFKVPLITVTN--SKVLLVLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd14971  237 VALGPFPLTYATyaLRIWAHCLAYSNSAVNPVLYAFLSEHFRKAF 281
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
368-634 5.68e-13

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 69.88  E-value: 5.68e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADfcmGLYLLLIASVDSQTKGQYynhaidWQTGSG-CSTAGFFT 446
Cdd:cd15973    9 LVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIAD---ELFMLSVPFLAASAALQH------WPFGSAmCRTVLSVD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 447 VFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSsLIAMLPLVGVSNYM----KVSICFPMDVETT 522
Cdd:cd15973   80 GINMFTSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILS-LLVISPIIIFADTAtrkgQAVACNLIWPHPA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 523 LSQVYIL-TILILNVVAFFIICACYIKIYFAVRNPELMA----TNKDTKIAKKMAILIFTDFT-CMAPISFFAISAAFkV 596
Cdd:cd15973  159 WSAAFVIyTFLLGFLLPVLAIGLCYILIIGKMRAVALKAgwqqRRKSEKKITRMVLMVVTVFViCWMPFYVVQLLNLF-L 237
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 106067657 597 PLITVTNSKVLLVLFYPiNSCANPFLYAIFTKTFQRDF 634
Cdd:cd15973  238 PRLDATVNHASLILSYA-NSCANPILYGFLSDNFRRSF 274
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
366-555 6.58e-13

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 69.75  E-value: 6.58e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 366 IWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGqyynhaidWQTGS-GCSTAGF 444
Cdd:cd15336    7 ILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKR--------WIFGEkGCELYAF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 445 FTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNY----MKVSICFpmDVE 520
Cdd:cd15336   79 CGALFGITSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLPPLFGWSAYvpegLLTSCTW--DYM 156
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 106067657 521 TTLSQVYILTILILNVVAF---FIICACYIKIYFAVRN 555
Cdd:cd15336  157 TFTPSVRAYTMLLFCFVFFiplGIIIYCYLFIFLAIRS 194
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
361-634 8.03e-13

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 69.64  E-value: 8.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVdsqtkgqyYNHAIDWQTGSG-C 439
Cdd:cd15048    2 VLAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIP--------YTLTGKWPFGKVfC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 STAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSL------IAMLPLVGVSNyMKVSI 513
Cdd:cd15048   74 KAWLVVDYTLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFLlygpaiIGWDLWTGYSI-VPTGD 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 514 CFpmdVETTLSQVYILTILILN-VVAFFIICACYIKIYFAVR-------------------------NPELMATNKDTKI 567
Cdd:cd15048  153 CE---VEFFDHFYFTFITSVLEfFIPFISVSFFNLLIYLNIRkrsrrrplrsvpilpasqnpsrarsQREQVKLRRDRKA 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 106067657 568 AKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15048  230 AKSLAILVLVFLICWAPYTILTIIRSFCSGSCVDSYLYEFTFWLLWTNSAINPFLYAACHPRFRKAF 296
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
368-634 8.61e-13

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 69.63  E-value: 8.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFAD-----FCMGLYLLLIASVDSqtkgqyynhaidWQTGSG-CST 441
Cdd:cd14997    9 VIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADllvllVCMPVALVETWAREP------------WLLGEFmCKL 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 442 AGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFsSLIAMLPLVGVSNYMK--------VSI 513
Cdd:cd14997   77 VPFVELTVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLL-ALLTSSPVLFITEFKEedfndgtpVAV 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 514 CFpMDVETTLSQVYILTILIL-NVVAFFIICACYIKI-YFAVRNPELMATNKDTKIAKKM----------AILIFTDFTC 581
Cdd:cd14997  156 CR-TPADTFWKVAYILSTIVVfFVVPLAILSGLYSVIcRRLVGHPALESRRADAANRHTLrsrrqvvymlITVVVLFFVC 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 106067657 582 MAPISFFAISAAFKVP-------LITVTNSKVLL-VLFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd14997  235 LLPFRVVTLWIIFAPDedlqalgLEGYLNLLVFCrVMVY-LNSALNPILYNLMSTKFRSAF 294
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
368-634 1.90e-12

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 68.57  E-value: 1.90e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAidwqtgsGCSTAGFFTV 447
Cdd:cd15208    9 LVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQV-------LCKIIPYLQT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 448 FASELSVYTLTVITLERWHTITYAihLDQKLRLRHAILIMLGGWLFSSLIA-----------MLPLVGVSNYMKVsiCFP 516
Cdd:cd15208   82 VSVSVSVLTLSCIALDRWYAICHP--LMFKSTAKRARVSILIIWIVSLLIMipqaivmecsrVVPLANKTILLTV--CDE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 517 MDVETTLSQVYILTI--------LILNVVAFFIIC------------ACYIKIYFAVRNPELMATNKDT---KIAKKMAI 573
Cdd:cd15208  158 RWSDSIYQKVYHICFflvtyllpLCLMILAYFQIFrklwcrqipgtsSVVQRKWNKPRKSAVAAEEKQLrsrRKTAKMLI 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 106067657 574 LIFTDFT-CMAPISFFAISAAFKVpLITVTNSKVLL------VLFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15208  238 VVVIMFAiCYLPVHLLNILRYVFG-LFTVDRETIYAwflfshWLVY-ANSAINPIIYNFMSGKFREEF 303
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
364-634 2.35e-12

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 68.09  E-value: 2.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFcmgLYLLLIASVdsqTKGQYYnhAIDWQTG-SGCSTA 442
Cdd:cd15096    5 VIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADL---LFVVFCVPF---TATDYV--LPTWPFGdVWCKIV 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 443 GFFTVFASELSVYTLTVITLERWHTITYAIHlDQKLRLRHAILIMLGG-W--LFSSLIAMLPLVGVSNYM----KVSICF 515
Cdd:cd15096   77 QYLVYVTAYASVYTLVLMSLDRYLAVVHPIT-SMSIRTERNTLIAIVGiWivILVANIPVLFLHGVVSYGfsseAYSYCT 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 516 PMDVETTLSQVYILTILILN-VVAFFIICACYIKIYFAVRNPELMATN------KDTKIAKKMAILIFTDFT-CMAPISF 587
Cdd:cd15096  156 FLTEVGTAAQTFFTSFFLFSyLIPLTLICVLYMLMLRRLRRQKSPGGRrsaesqRGKRRVTRLVVVVVVVFAiCWLPIHI 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 106067657 588 FAISAAFKVPLITVTnSKVLLVLFYPI---NSCANPFLYAIFTKTFQRDF 634
Cdd:cd15096  236 ILLLKYYGVLPETVL-YVVIQILSNCLaygNSCVNPILYAFLSQNFRKAF 284
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
362-634 2.57e-12

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 68.23  E-value: 2.57e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 362 LRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIasvdsqTKGQYYNHAidWQTGS-GCS 440
Cdd:cd14992    3 LGVALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPF------NFTYVVSLS--WEYGHfLCK 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 441 TAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIA--------MLPLVGVSNYMKVS 512
Cdd:cd14992   75 IVNYLRTVSVYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAipqlyyatTEVLFSVKNQEKIF 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 513 IC-FPMDVETTLSQVYILTI-LILNVVAFFIICACYIKIYF---AVRNP-------ELMATNKDTKIAKKMAILIFTDFT 580
Cdd:cd14992  155 CCqIPPVDNKTYEKVYFLLIfVVIFVLPLIVMTLAYARISRelwFRKVPgfsikevERKRLKCKRRVIKMLVCVVVLFVI 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 106067657 581 CMAPI-SFFAISAAFKVPLITVTNSKVLLVLFY--PINSCANPFLYAIFTKTFQRDF 634
Cdd:cd14992  235 CWLPFhLFFLLRDFFPLIMKEKHTLQVYYFLHWiaMSNSMYNPIIYVTLNNNFRKNF 291
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
368-634 2.79e-12

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 68.13  E-value: 2.79e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFcmgLYLLLIASVDSQTKGQYYnhaiDWQTGSG-CSTAGFFT 446
Cdd:cd15134    9 IIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDL---LLLILGLPFELYTIWQQY----PWVFGEVfCKLRAFLS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 447 VFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAM------------LPLVGVSNYMKVSIC 514
Cdd:cd15134   82 EMSSYASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALpfaiqtrivyleYPPTSGEALEESAFC 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 515 FPMDVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPEL--------MATNKDTK----IAKKMAILIFTDFTCM 582
Cdd:cd15134  162 AMLNEIPPITPVFQLSTFLFFIIPMIAIIVLYVLIGLQLRRSTLlrrgqrsvSGGRRSSQsrrtVLRMLVAVVVAFFICW 241
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 106067657 583 APisFFAISaafkvpLITVTNSK-------VLLVLFYP------INSCANPFLYAIFTKTFQRDF 634
Cdd:cd15134  242 AP--FHAQR------LLTVYAKNmtppylfINRILFYIsgvlyyVSSTVNPILYNVMSAKYRQAF 298
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
364-634 3.33e-12

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 67.83  E-value: 3.33e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVdsqtkgqyYNHAIDWQTGS-GCSTA 442
Cdd:cd15197    5 ATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVLTDII--------WRITVEWRAGDfACKVI 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 443 GFFTVFASELSVYTLTVITLERWHTITYAIHLDQKlrLRHAILIMLGGWLFSSL--IAMLPLVG----VSNYMKVSICFP 516
Cdd:cd15197   77 RYLQVVVTYASTYVLVALSIDRYDAICHPMNFSQS--GRQARVLICVAWILSALfsIPMLIIFEktglSNGEVQCWILWP 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 517 MDVETtlsQVYiltILILNVVAFF----IICACYI----------KIYFAVRNPELMATNKDTKIAK-----------KM 571
Cdd:cd15197  155 EPWYW---KVY---MTIVAFLVFFipatIISICYIiivrtiwkksKIQVTINKAGLHDGSSRRSSSRgiiprakiktiKM 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 106067657 572 AILIFTDFT-CMAPISFFAISAAFKvpLITVTNSKVLLVLFY----PINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15197  229 TFVIVTVFIiCWSPYFVFDLLDVFG--LLPRSKTKIAAATFIqslaPLNSAINPLIYCLFSTHLCRPL 294
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
368-634 4.11e-12

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 67.24  E-value: 4.11e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADfcmglyLLLIASVDSQTKGQYYNHaidWQTGS-------GCS 440
Cdd:cd15970    9 VVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIAD------ELLMLSVPFLVTSTLLRH---WPFGSllcrlvlSVD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 441 TAGFFTvfaselSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIaMLPLVGVSNYMKVS-------I 513
Cdd:cd15970   80 AINMFT------SIYCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILV-ILPIIIFSNTAPNSdgsvacnM 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 514 CFPMDVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKK----MAILIFTDFT-CMAPISFF 588
Cdd:cd15970  153 QMPEPSQRWLAVFVVYTFLMGFLLPVIAICLCYILIIVKMRVVALKAGWQQRKRSERkitlMVMMVVTVFViCWMPFYVV 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 106067657 589 AISAAFkVPLITVTNSKVLLVLFYPiNSCANPFLYAIFTKTFQRDF 634
Cdd:cd15970  233 QLVSVF-VGQHDATVSQLSVILGYA-NSCANPILYGFLSDNFKRSF 276
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
364-634 6.53e-12

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 66.56  E-value: 6.53e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLlTSRYKLTVPRFLMCNLSFADFCMGLYLLLIAsvdsqtkgQYYNHAIDWQTGS-GC--- 439
Cdd:cd14974    5 VLYALIFLLGLPGNGLVIWVA-GFKMKRTVNTVWFLNLALADFLFCLFLPFLI--------VYIAMGHHWPFGSvLCkln 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 STAGFFTVFASelsVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLV--GVSNYMKVSICFP- 516
Cdd:cd14974   76 SFVISLNMFAS---VFLLTAISLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLSVPYFVfrDTVTHHNGRSCNLt 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 517 --MDVETTLSQVYILTI---LILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIakkMAILIFTDFTCMAPISFFA-- 589
Cdd:cd14974  153 cvEDYDLRRSRHKALTVirfLCGFLLPLLIIAICYSVIAVKLRRKRLAKSSKPLRV---LLAVVVAFFLCWLPYHVFAll 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 106067657 590 -ISAAFKVPLITVTNSKVLLVLFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd14974  230 eLVAAAGLPEVVLLGLPLATGLAY-FNSCLNPILYVFMGQDFRKRL 274
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
365-634 7.69e-12

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 66.68  E-value: 7.69e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 365 LIWLINILAIMGNMTVLFVLLTSRY-KLTVPRFLMCNLSFADFCMGLYLLLIASVdSQTKGQyynhaidWQTGSGCSTAG 443
Cdd:cd15057    6 ILYLLVLLTLLGNALVIAAVLRFRHlRSKVTNYFIVSLAVSDLLVAILVMPWAAV-NEVAGY-------WPFGSFCDVWV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 444 FFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPL------VGVSNYMKVSICFPM 517
Cdd:cd15057   78 SFDIMCSTASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISFIPVqlgwhrADDTSEALALYADPC 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 518 DVETTLSQVY-ILTILILNVVAFFIICACYIKIYFAVR-----------------NPEL---MATNKDTKIAKKMAILI- 575
Cdd:cd15057  158 QCDSSLNRTYaISSSLISFYIPVAIMIVTYTRIYRIARrqirriaaleraaqestNPDSslrSSLRRETKALKTLSIIMg 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 106067657 576 --------FTDFTCMAPISFFAISAAFKVPLITVTnskvLLVLFYPINSCANPFLYAiFTKTFQRDF 634
Cdd:cd15057  238 vfvccwlpFFILNCVLPFCDLRTAQFPCVPDTTFI----VFVWLGWANSSLNPIIYA-FNADFRKAF 299
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
361-634 9.26e-12

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 66.32  E-value: 9.26e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLiasvdsqtKGQYYNHAIDWQTGSG-C 439
Cdd:cd15162    2 FLPAVYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPF--------KIAYHIHGNNWIFGEAlC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 S--TAGFFTVFASelSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSsLIAMLPLVGVSNYMKV-----S 512
Cdd:cd15162   74 RlvTVAFYGNMYC--SILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLA-LLVTLPLYLVKQTIFLpaldiT 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 513 ICFPMDVETTLSQVYILTILILNVVAFFI----ICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDF-TCMAPISF 587
Cdd:cd15162  151 TCHDVLPEQLLVGDWFYYFLSLAIVGFLIpfilTASCYVATIRTLAALEDENSEKKKKRAIKLAATVLAIFiICFAPSNL 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 106067657 588 FAIsAAFKVPLITVTNS----KVLLVLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15162  231 LLL-AHYSLISSSGTGHlyfaYLLALCLSTLNSCIDPFIYYFVSKEFRDHV 280
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
363-634 1.11e-11

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 66.27  E-value: 1.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 363 RVLI-WLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVdsqtkgqyYNHAIDWQTGS-GCS 440
Cdd:cd15195    3 RVLVtWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPMDAV--------WNYTVEWLAGDlMCR 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 441 TAGFFTVFASELSVYTLTVITLERWHTITYAI-HLDQKLRLRHAILImlgGWLFSSLIAMLPLV--GVSNYMKVSICFPM 517
Cdd:cd15195   75 VMMFLKQFGMYLSSFMLVVIALDRVFAILSPLsANQARKRVKIMLTV---AWVLSALCSIPQSFifSVLRKMPEQPGFHQ 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 518 DV-------ETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNpeLMATNKDT-----------------KIAKKMAI 573
Cdd:cd15195  152 CVdfgsaptKKQERLYYFFTMILSFVIPLIITVTCYLLILFEISK--MAKRARDTpisnrrrsrtnslerarMRTLRMTA 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 106067657 574 LIFTDF-TCMAPISFFAISAAFKVPLITVTN---SKVLLVLFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15195  230 LIVLTFiVCWGPYYVLGLWYWFDKESIKNLPpalSHIMFLLGY-LNPCLHPIIYGVFMKEIRNWI 293
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
368-634 2.25e-11

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 64.95  E-value: 2.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIdwqtgsgCSTAGFFTV 447
Cdd:cd15196    9 TILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALFNVLPQLIWDITYRFYGGDLL-------CRLVKYLQV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 448 FASELSVYTLTVITLERWHTITYAIHlDQKLRLRHAILIMLGGWLFSsLIAMLPLVGVSNYMKVSI----CFPMDVETTL 523
Cdd:cd15196   82 VGMYASSYVLVATAIDRYIAICHPLS-SHRWTSRRVHLMVAIAWVLS-LLLSIPQLFIFSYQEVGSgvydCWATFEPPWG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 524 SQVYILTILILN-VVAFFIICACYIKIYFAVRNpelmatnKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVT 602
Cdd:cd15196  160 LRAYITWFTVAVfVVPLIILAFCYGRICYVVWR-------AKIKTVKLTLVVVACYIVCWTPFFVVQMWAAWDPTAPIEG 232
                        250       260       270
                 ....*....|....*....|....*....|..
gi 106067657 603 NSKVLLVLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15196  233 PAFVIIMLLASLNSCTNPWIYLAFSGNLRRAL 264
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
365-634 2.76e-11

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 64.56  E-value: 2.76e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 365 LIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLyLLLIASVDSQTKGQYYNHAIdWqtgsgCSTAGF 444
Cdd:cd15321   12 AITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVAT-LIIPFSLANELMGYWYFRKT-W-----CEIYLA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 445 FTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPmDVETTLS 524
Cdd:cd15321   85 LDVLFCTSSIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIYKGKQKDEQGGLP-QCKLNEE 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 525 QVYILTIlilNVVAFFIICACYIKIYFAVRnpeLMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNS 604
Cdd:cd15321  164 AWYILSS---SIGSFFAPCLIMILVYLRIY---LIAKNREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPELCKVPHS 237
                        250       260       270
                 ....*....|....*....|....*....|...
gi 106067657 605 kvLLVLFYPI---NSCANPFLYAIFTKTFQRDF 634
Cdd:cd15321  238 --LFQFFFWIgycNSSLNPVIYTIFNQDFRRAF 268
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
369-632 2.78e-11

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 64.76  E-value: 2.78e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 369 INILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSqtkgqYYNHaidWQTG-SGCSTAGFFTV 447
Cdd:cd15073   10 AGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASD-----LHGS---WKFGyAGCQWYAFLNI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 448 FASELSVYTLTVITLERWHTITyAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSnymkvsiCFPMDVETTLSQV- 526
Cdd:cd15073   82 FFGMASIGLLTVVAVDRYLTIC-RPDLGRKMTTNTYTVMILLAWTNAFFWAAMPLVGWA-------SYALDPTGATCTIn 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 527 ----------YILTILILN-VVAFFIICACYIKIYFAVR----NPELMATNKD----TKIAKKMAILIFTDFTCMAPISF 587
Cdd:cd15073  154 wrkndssfvsYTMSVIVVNfIVPLAVMFYCYYNVSRFVKkvlaSDCLESVNIDwtdqNDVTKMSVIMIVMFLVAWSPYSI 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 106067657 588 FAISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQR 632
Cdd:cd15073  234 VCLWASFGEPKKIPPWMAIIPPLFAKSSTFYNPCIYVIANKKFRR 278
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
371-634 3.17e-11

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 64.53  E-value: 3.17e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 371 ILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGlYLLLIASVDSQTKGQyynhaidWQTGS-GCSTAGFFTVFA 449
Cdd:cd15326   12 LFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLS-FTVLPFSATLEILGY-------WVFGRiFCDIWAAVDVLC 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 450 SELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNymkvsicfPMDVETTLSQVY-- 527
Cdd:cd15326   84 CTASILSLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIGPLLGWKE--------PAPPDDKVCEITee 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 528 ILTILILNVVAFFI----ICACYIKIYFAVrnpelMATNKDTKIAKKMAILIFTDFTCMAPisFF------AISAAFKVP 597
Cdd:cd15326  156 PFYALFSSLGSFYIplivILVMYCRVYIVA-----LKFSREKKAAKTLGIVVGMFILCWLP--FFialplgSLFSHLKPP 228
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 106067657 598 litVTNSKVLLVLFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15326  229 ---ETLFKIIFWLGY-FNSCLNPIIYPCSSKEFKRAF 261
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
361-634 3.49e-11

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 64.54  E-value: 3.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADfcmglyLLLIASVDSQTkgqyYNHAIDWQTGSG-C 439
Cdd:cd14984    2 FLPVLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALAD------LLFVLTLPFWA----VYAADGWVFGSFlC 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 -STAGFFTV-FASelSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLV--GVSNYMKVSICF 515
Cdd:cd14984   72 kLVSALYTInFYS--GILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIfsQVSEENGSSICS 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 516 PMDVETTLSQVYILTILILNVVAFF----IICACY---IKIYFAVRNPelmatnKDTKIAKKMAILIFTDFTCMAPISFF 588
Cdd:cd14984  150 YDYPEDTATTWKTLLRLLQNILGFLlpllVMLFCYsriIRTLLRARNH------KKHRALRVIFAVVVVFFLCWLPYNIV 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 106067657 589 AISAAFKVPLITVTNSKVLLVLFYPI---------NSCANPFLYAIFTKTFQRDF 634
Cdd:cd14984  224 LLLDTLQLLGIISRSCELSKSLDYALqvteslafsHCCLNPVLYAFVGVKFRKYL 278
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
361-631 3.93e-11

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 64.38  E-value: 3.93e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFcmgLYLLLIASVDSQtkgqYYNHaiDWQTGS-GC 439
Cdd:cd14999    1 AIGTVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADL---LYLLTIPFYVST----YFLK--KWYFGDvGC 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 S---TAGFFTVFASelsVYTLTVITLERWHTITYAIhlDQKLR-LRHAILIMLGGWLFSSLIA-----MLPLVGVSNYMK 510
Cdd:cd14999   72 RllfSLDFLTMHAS---IFTLTVMSTERYLAVVKPL--DTVKRsKSYRKLLAGVIWLLSLLLTlpmaiMIRLVTVEDKSG 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 511 VS--ICFPMDVETTlSQVYILTILILNVVA-FFIICACYIKIYFAVRNPELMATNKDTK--IAKKMAILIFTD----FTC 581
Cdd:cd14999  147 GSkrICLPTWSEES-YKVYLTLLFSTSIVIpGLVIGYLYIRLARKYWLSQAAASNSSRKrlPKQKVLKMIFTIvlvfWAC 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 106067657 582 MAPISFFAI----SAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQ 631
Cdd:cd14999  226 FLPFWIWQLlylySPSLSLSPRTTTYVNYLLTCLTYSNSCINPFLYTLLTKNYK 279
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
364-632 4.01e-11

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 64.40  E-value: 4.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFcmgLYLLLIASVDSQ--TKGQYYNHAIDWQTGSGCST 441
Cdd:cd15088    5 SVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADL---LFMLGMPFLIHQfaIDGQWYFGEVMCKIITALDA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 442 AGFFTvfaselSVYTLTVITLERWHTITYAIHLdQKLRLRH-AILIMLGGWLfSSLIAMLPLVGVSNYMK----VSIC-- 514
Cdd:cd15088   82 NNQFT------STYILTAMSVDRYLAVVHPIRS-TKYRTRFvAKLVNVGLWA-ASFLSILPVWVYSSLIYfpdgTTFCyv 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 515 -FPMDVETTLSQVYILTILIlnVVAFFIICACYIKI--YFA--VRNPELMATNKDTKIAKKMAILIFTDFT-CMAPISFF 588
Cdd:cd15088  154 sLPSPDDLYWFTIYHFILGF--AVPLVVITVCYILIlhRLArgVAPGNQSHGSSRTKRVTKMVILIVVVFIvCWLPFHVV 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 106067657 589 A-ISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQR 632
Cdd:cd15088  232 QlVNLAMNRPTLAFEVAYFLSICLGYANSCLNPFVYILVSENFRK 276
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
364-634 4.18e-11

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 64.24  E-value: 4.18e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGL-YLLLIASVDsqtkgqyYNHAIDWQTGSGCSTA 442
Cdd:cd14972    3 VVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIaFVFTFLSVL-------LVSLTPSPATWLLRKG 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 443 GFFTVFASelSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGvSNYMKVSICFPMDVETT 522
Cdd:cd14972   76 SLVLSLLA--SAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALLPVLG-WNCVLCDQESCSPLGPG 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 523 LSQVYILTILILNVVAFFIICACYIKIYFAV-RNPELMATN----------KDTKIAKKMAILIFTDFTCMAPIS--FFA 589
Cdd:cd14972  153 LPKSYLVLILVFFFIALVIIVFLYVRIFWCLwRHANAIAARqeaavpaqpsTSRKLAKTVVIVLGVFLVCWLPLLilLVL 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 106067657 590 ISAAFKVPLI-TVTNSKVLLVLFypiNSCANPFLYAIFTKTFQRDF 634
Cdd:cd14972  233 DVLCPSVCDIqAVFYYFLVLALL---NSAINPIIYAFRLKEMRRAV 275
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
364-634 4.19e-11

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 64.05  E-value: 4.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAidWqtgsgCSTAG 443
Cdd:cd15063    5 LVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHT--W-----CQIWL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 444 FFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVET-- 521
Cdd:cd15063   78 AVDVWMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLVGWNDGKDGIMDYSGSSSLpc 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 522 ----TLSQVYIL-TILILNVVAFFIICACYIKIYFAVRnpelmatnKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKV 596
Cdd:cd15063  158 tcelTNGRGYVIySALGSFYIPMLVMLFFYFRIYRAAR--------METKAAKTVAIIVGCFIFCWLPFFTVYLVRAFCE 229
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 106067657 597 PLITVTNSKVLLVLFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15063  230 DCIPPLLFSVFFWLGY-CNSALNPCIYALFSRDFRFAF 266
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
361-634 6.11e-11

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 63.53  E-value: 6.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDsqtkgQYYNHaidWQTGSG-C 439
Cdd:cd15061    1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIR-----QLLGY---WPLGSHlC 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 STAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMK---VSICFP 516
Cdd:cd15061   73 DFWISLDVLLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLVGPSWHGRrglGSCYYT 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 517 MDVE----TTLSQVYILTILILNVvaffiicacYIKIYFAVrnpelmatNKDTKIAKKMAILIFTDFTCMAPISFFAISA 592
Cdd:cd15061  153 YDKGyriySSMGSFFLPLLLMLFV---------YLRIFRVI--------AKERKTAKTLAIVVGCFIVCWLPFFIMYLIE 215
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 106067657 593 AFKVPLITVTNSKVLLVLFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15061  216 PFCDCQFSEALSTAFTWLGY-FNSVINPFIYAFYNKDFRRAF 256
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
361-634 7.17e-11

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 63.06  E-value: 7.17e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRyKLTVP-RFLMCNLSFADFCMGLYLLLIASVDsQTKGQyynhaidWQTGSG- 438
Cdd:cd15329    2 LIGIVLLIIILGTVVGNALVIIAVCLVK-KLRTPsNYLIVSLAVSDLLVALLVMPLAIIY-ELSGY-------WPFGEIl 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 439 CSTAGFFTVFASELSVYTLTVITLERWHTIT----YAIhldQKLRLRHAILIMLGgWLFSSLIAMLPLVGVSNYMKVS-I 513
Cdd:cd15329   73 CDVWISFDVLLCTASILNLCAISVDRYLVITrpltYAV---KRTPKRMALMIAIV-WLLSALISIPPLFGWKNKVNDPgV 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 514 CFpmdvettLSQVYILTILIlNVVAFFI----ICACYIKIYfavrnpelMATNKDTKIAKKMAIlIFTDFT-CMAPisFF 588
Cdd:cd15329  149 CQ-------VSQDFGYQIYA-TFGAFYIplivMLVLYYKIY--------RAAKSERKAIKTLGI-IMGAFTlCWLP--FF 209
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 106067657 589 AISAA------FKVPLITVTNSKVLLVLFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15329  210 ILALLrpflkpIKCSCIPLWLSRLFLWLGY-ANSFLNPIIYAKFNREFRTPF 260
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
364-623 8.03e-11

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 63.22  E-value: 8.03e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAidwqtgsGCSTAG 443
Cdd:cd14964    3 IILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQA-------LCYLIY 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 444 FFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGV------SNYMKVSICFPM 517
Cdd:cd14964   76 LLWYGANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKgaipryNTLTGSCYLICT 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 518 DVETTLSqvYILTILILNVVAFFIICACYIK----IYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAA 593
Cdd:cd14964  156 TIYLTWG--FLLVSFLLPLVAFLVIFSRIVLrlrrRVRAIRSAASLNTDKNLKATKSLLILVITFLLCWLPFSIVFILHA 233
                        250       260       270
                 ....*....|....*....|....*....|.
gi 106067657 594 FkVPLITVTNSKVLLVLF-YPINSCANPFLY 623
Cdd:cd14964  234 L-VAAGQGLNLLSILANLlAVLASTLNPFIY 263
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
371-632 9.86e-11

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 63.48  E-value: 9.86e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 371 ILAIMGNMTVLFVLLTSRYKlTVPR--FLMCNLSFADFCMGLYLLLIASVDSQTkgqyynhaIDWQTGS-GCSTAGFFTV 447
Cdd:cd15382   12 LIAAVGNLTVLLILLRNRRR-KRSRvnILLMHLAIADLLVTFIMMPLEIGWAAT--------VAWLAGDfLCRLMLFFRA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 448 FASELSVYTLTVITLERWHTITYAIHLdqkLRLRHAILIMLGG-WLFSSLIAMLPLV--GVSNYMKV---SIC-----FP 516
Cdd:cd15382   83 FGLYLSSFVLVCISLDRYFAILKPLRL---SDARRRGRIMLAVaWVISFLCSIPQSFifHVESHPCVtwfSQCvtfnfFP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 517 MD-VETTLSqvyILTILILNVVAFFIICACYIKIYFAVRN--------------PELMATNKDTKIAK------KMAILI 575
Cdd:cd15382  160 SHdHELAYN---IFNMITMYALPLIIIVFCYSLILCEISRkskekkedvsekssSVRLRRSSVGLLERarsrtlKMTIVI 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 106067657 576 -------FTDFTCMAPISFFAISAAFKVPLITvtnsKVLLVLFYPINSCANPFLYAIFTKTFQR 632
Cdd:cd15382  237 vlvfiicWTPYFIMSLWYWFDRESASKVDPRI----QKGLFLFAVSNSCMNPIVYGYFSIDLRR 296
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
360-634 1.39e-10

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 62.86  E-value: 1.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 360 DFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADfcmglyLLLIASVDSQTKGQYYNHaiDWQTGSG- 438
Cdd:cd15368    1 VILPVVYSLVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTD------LMLACFLPFQIVYHIQRN--HWIFGKPl 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 439 CS--TAGFFTVFASelSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFsSLIAMLPLVGVS-----NYMKV 511
Cdd:cd15368   73 CNvvTVLFYANMYS--SILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLL-VLTALSPLERTDltyyvKELNI 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 512 SICFPMDVETTLSQV-----YILTI-LILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDF-TCMAP 584
Cdd:cd15368  150 TTCFDVLKWTMLPNIaawaaFLFTLfILLFLIPFIITVYCYVLIILKLVQTSERYGREQKRRAIYLALIVLLVFiTCFAP 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 106067657 585 ISFF-------------AISAAFKVPLITVTnskvllvlfypINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15368  230 NNFIllahmvsrlfygkSLYHAYKLTLSLSC-----------LNSCLDPFIYYFASKEFRKKL 281
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
364-634 1.52e-10

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 62.41  E-value: 1.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIdwqtgsgCSTAG 443
Cdd:cd15206    5 PLYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVM-------CKLIP 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 444 FFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIaMLPLVGVSNYMKVS-ICFPMDVETT 522
Cdd:cd15206   78 YFQAVSVSVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLI-MSPILVFSNLIPMSrPGGHKCREVW 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 523 LSQV-----YILTILILNVVAFFIICACYIKIYFavrnpELMATNKdtKIAKKMAILIFTDFTCMAPISFFAISAAFKVP 597
Cdd:cd15206  157 PNEIaeqawYVFLDLMLLVIPGLVMSVAYGLISW-----TLLEAKK--RVIRMLFVIVVEFFICWTPLYVINTWKAFDPP 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 106067657 598 LITVTNSKV---LLVLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15206  230 SAARYVSSTtisLIQLLAYISSCVNPITYCFMNKRFRQAF 269
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
361-634 2.37e-10

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 61.85  E-value: 2.37e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIwlinILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIdwqtgsgCS 440
Cdd:cd15327    6 FLAIFI----LMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVF-------CD 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 441 TAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKV--SICfpmd 518
Cdd:cd15327   75 IWAAVDVLCCTASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIGPLLGWKEPPPPdeSIC---- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 519 vETTLSQVYIL-TILILNVVAFFIICACYIKIYFAVrnpelMATNKDTKIAKKMAILIFTDFTCMAPIsFFAISAAFKVP 597
Cdd:cd15327  151 -SITEEPGYALfSSLFSFYLPLMVILVMYFRVYVVA-----LKFSREKKAAKTLAIVVGVFILCWFPF-FFVLPLGSFFP 223
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 106067657 598 LITVTNS--KVLLVLFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15327  224 ALKPSEMvfKVIFWLGY-FNSCVNPIIYPCSSKEFKRAF 261
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
449-634 2.89e-10

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 61.57  E-value: 2.89e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 449 ASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVG---VSNYMKV--SICFPMdvetTL 523
Cdd:cd15049   83 ASNASVMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFVLWAPAILGwqyFVGERTVpdGQCYIQ----FL 158
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 524 SQVYILTILIlnVVAF----FIICACYIKIYfavrnpelMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLI 599
Cdd:cd15049  159 DDPAITFGTA--IAAFylpvLVMTILYWRIY--------RETARERKAARTLSAILLAFIITWTPYNILVLVSTFCAKCI 228
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 106067657 600 TVTNSKVLLVLFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15049  229 PDTLWSFGYWLCY-INSTINPFCYALCNKTFRKTF 262
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
366-632 3.51e-10

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 61.71  E-value: 3.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 366 IWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFAD--FCMGLYLLLIasvdsqtkgqYYNHAIDWQTGSG-CSTA 442
Cdd:cd15381    7 LWIIFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADllLVCCLPFWAI----------NISNGFNWPFGEFlCKSV 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 443 GFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLV--GVSNYMKVSICFPMDVE 520
Cdd:cd15381   77 NAVIYMNLYSSIYFLMMVSIDRYLALVKTMSSGRMRRPACAKLNCLIIWMFGLLMSTPMIVfrTVMYFPEYNITACVLDY 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 521 TTLSQVYILTILiLNVVAFF----IICACYIKIYFAVRN---PELMATNKDTKIAKKMAILIFTDFTCMAPISFFA-ISA 592
Cdd:cd15381  157 PSEGWHVALNIL-LNVVGFLiplsIITFCSTQIIQVLRNnkmQKFKEIQTERKATVLVLAVLLMFFICWLPFHIFTfLDT 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 106067657 593 AFKVPLITVTNSKVLLVLFYPI-------NSCANPFLYAIFTKTFQR 632
Cdd:cd15381  236 LHKLGLISGCRWEDILDIGTQIatflaysNSCLNPLLYVIVGKHFRK 282
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
361-634 3.84e-10

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 61.40  E-value: 3.84e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFAD--FCMGLYLLLIASVdsqtkgqyynhAIDWQTGSG 438
Cdd:cd15971    2 FLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADelFMLGLPFLAIQVA-----------LVHWPFGKA 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 439 -CSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSsLIAMLPLV---GVSNYMKVSIC 514
Cdd:cd15971   71 iCRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVS-LLVILPIMiyaGVQTKHGRSSC 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 515 ---FPMDVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMA-----TNKDTKIAKKMAILIFTDFTCMAPIS 586
Cdd:cd15971  150 tiiWPGESSAWYTGFIIYTFILGFFVPLTIICLCYLFIIIKVKSSGIRVgsskrKKSEKKVTRMVSIVVAVFVFCWLPFY 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 106067657 587 FF---AISAAFKVPLITVTNSKVLLVLFYPiNSCANPFLYAIFTKTFQRDF 634
Cdd:cd15971  230 IFnvsSVSVSISPTPGLKGMFDFVVVLSYA-NSCANPILYAFLSDNFKKSF 279
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
368-630 4.34e-10

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 61.29  E-value: 4.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLL-LIASVDSQTKGQYYNHAIdwqtgsgCSTAGFF- 445
Cdd:cd15394    9 LVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVpLTLAYAFEPRGWVFGRFM-------CYFVFLMq 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 446 --TVFaseLSVYTLTVITLERWHTITYAIHldQKLRLRHAILIMLGGWLFSSLIAmLPLVGVSNYMK-----VSIC--FP 516
Cdd:cd15394   82 pvTVY---VSVFTLTAIAVDRYYVTVYPLR--RRISRRTCAYIVAAIWLLSCGLA-LPAAAHTYYVEfkgldFSICeeFW 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 517 MDVETTlSQVYILTILILN-VVAFFIICACYIKIYFAVRN---PELMA-TNKDTKIAKK-----MAILIFTDF-TCMAPI 585
Cdd:cd15394  156 FGQEKQ-RLAYACSTLLITyVLPLLAISLSYLRISVKLRNrvvPGSMTqSQAEWDRARRrktfrLLVVVVVAFaICWLPL 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 106067657 586 SFFAISAAFKVPLIT---VTNSKVLLVLFYPINSCANPFLYAIFTKTF 630
Cdd:cd15394  235 HIFNVIRDIDIDLIDkqyFNLIQLLCHWLAMSSACYNPFLYAWLHDSF 282
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
362-634 4.97e-10

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 60.73  E-value: 4.97e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 362 LRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLyLLLIASVDSQTKGQYYNHAIdWqtgsgCST 441
Cdd:cd15322    3 LIILVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVAT-LVIPFSLANEVMGYWYFGKV-W-----CEI 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 442 AGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGV---SNYMKVSICfpmd 518
Cdd:cd15322   76 YLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIekkSGQPEGPIC---- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 519 vETTLSQVYILTILIlnvVAFFIICACYIKIYFAVRNpelMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPL 598
Cdd:cd15322  152 -KINDEKWYIISSCI---GSFFAPCLIMVLVYIRIYQ---IAKNREKRFTFVLAVVIGVFVICWFPFFFTYTLTAVCDCS 224
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 106067657 599 ITVTNSKVLLVLFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15322  225 VPETLFKFFFWFGY-CNSSLNPVIYTIFNHDFRRAF 259
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
364-632 9.41e-10

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 60.15  E-value: 9.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLiasvdsqtKGQYYNHAIDWQTGSG-CSTA 442
Cdd:cd15012    4 ILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVL--------QNLSIYLIPSWPFGEVlCRMY 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 443 GFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMlPLVGVSNYMKVSI--------C 514
Cdd:cd15012   76 QFVHSLSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNT-PYFVFSQTVEILVtqdgqeeeI 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 515 FPMDVETTLSQVY-ILTILILNVVAFFIICACYIKIYFAVRNPelmATNKDTKIAKKMAILIFTDFT-CMAPISFFAISA 592
Cdd:cd15012  155 CVLDREMFNSKLYdTINFIVWYLIPLLIMTVLYSKISIVLWKS---SSIEARRKVVRLLVAVVVSFAlCNLPYHARKMWQ 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 106067657 593 AFKVPLITVTNSKVLLV----LFYPINSCANPFLYAIFTKTFQR 632
Cdd:cd15012  232 YWSEPYRCDSNWNALLTpltfLVLYFNSAVNPLLYAFLSKRFRQ 275
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
364-634 1.37e-09

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 59.74  E-value: 1.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSR---YKLTVPRFLMcNLSFADFcmglyLLLIASVDSQtkGQYYNHAiDWQTGSG-C 439
Cdd:cd15098    5 VVFGLIFCLGVLGNSLVITVLARVKpgkRRSTTNVFIL-NLSIADL-----FFLLFCVPFQ--ATIYSLP-EWVFGAFmC 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 STAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMlP------LVGVSNYMKVSI 513
Cdd:cd15098   76 KFVHYFFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMAS-PvavhqdLVHHWTASNQTF 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 514 CFPMDVETTLSQVYILTILILN-VVAFFIICACYIKIYFAV-RNPELMA--TNKDTKIAKKMAILIFTDFT-CMAPISFF 588
Cdd:cd15098  155 CWENWPEKQQKPVYVVCTFVFGyLLPLLLITFCYAKVLNHLhKKLKNMSkkSERSKKKTAQTVLVVVVVFGiSWLPHHII 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 106067657 589 AISAAF-KVPLitvTNSKVLLVLF-----YPiNSCANPFLYAIFTKTFQRDF 634
Cdd:cd15098  235 HLWVEFgDFPL---TQASFVLRITahclaYA-NSCVNPIIYAFLSENFRKAY 282
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
368-634 1.90e-09

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 59.40  E-value: 1.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFcmgLYLLLIASVDSQTKGQYynhaidWQTGSG-CSTAGFFT 446
Cdd:cd15093    9 VVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADE---LFMLGLPFLAASNALRH------WPFGSVlCRLVLSVD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 447 VFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSsLIAMLPLVGVS----NYMKVSIC---FPMDV 519
Cdd:cd15093   80 GINMFTSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVAS-LLVILPVVVFAgtreNQDGSSACnmqWPEPA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 520 ETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKK----MAILIFTDFT-CMAPISFFAISAAF 594
Cdd:cd15093  159 AAWSAGFIIYTFVLGFLLPLLIICLCYLLIVIKVKSAGLRAGWQQRKRSERkvtrMVVMVVVVFViCWLPFYVLQLVNVF 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 106067657 595 KVPLIT---VTNSKVLLVLFYPiNSCANPFLYAIFTKTFQRDF 634
Cdd:cd15093  239 VQLPETpalVGVYHFVVILSYA-NSCANPILYGFLSDNFKKSF 280
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
364-634 2.29e-09

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 58.98  E-value: 2.29e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLfvLLTSRYK-LTVP-RFLMCNLSFADFCMGLyLLLIASVDSQTKGQyynhaidWQTG-SGCS 440
Cdd:cd15086    5 VFLGFILTFGFLNNLLVL--VLFCKYKvLRSPiNLLLLNISLSDLLVCV-LGTPFSFAASTQGR-------WLIGeHGCR 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 441 TAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKlRLRHAILIMLGGWLFSSLIAMLPLVGVSNY----MKVSICFP 516
Cdd:cd15086   75 WYGFANSLFGIVSLISLAVLSYERYCTLLRPTEADVS-DYRKAWLGVGGSWLYSLLWTLPPLLGWSSYgpegPGTTCSVQ 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 517 MDVETTLSQVYILTILILN-VVAFFIICACYIKIYFAVRnpELMATNKDTKIAKKMAILIFTDFT------CMAPISFFA 589
Cdd:cd15086  154 WTSRSANSISYIICLFIFClLLPFLVMVYCYGRLLYAIK--QVGKINKSTARKREQHVLLMVVTMvicyllCWLPYGVMA 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 106067657 590 ISAAFKVP-LITVTNSKVLLVLFYPINSCaNPFLYAIFTKTFQRDF 634
Cdd:cd15086  232 LLATFGKPgLVTPVASIVPSILAKSSTVV-NPIIYVFMNKQFYRCF 276
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
361-632 2.59e-09

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 58.43  E-value: 2.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVdsqtkgQYYNHAidWQTGS-GC 439
Cdd:cd15210    2 FAAVWGIVFMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAAS------TFLHQA--WIHGEtLC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 STAGFFTVFASELSVYTLTVITLERWHTITYaIHLDQKLRLRHAILIMLGG-WLFSSLIAMLPLVGVSNYM----KVSIC 514
Cdd:cd15210   74 RVFPLLRYGLVAVSLLTLVLITLNRYILIAH-PSLYPRIYTRRGLALMIAGtWIFSFGSFLPLWLGIWGRFgldpKVCSC 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 515 FPMDVETTLSQVYILTililnVVAFFIICACYIKIYfavrnpelmATNKDTKIAkKMAILIFTDF-TCMAPISFFAIS-A 592
Cdd:cd15210  153 SILRDKKGRSPKTFLF-----VFGFVLPCLVIIICY---------ARREDRRLT-RMMLVIFLCFlVCYLPITLVNVFdD 217
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 106067657 593 AFKVPLITVTNSkvllVLFYpINSCANPFLYAIFTKTFQR 632
Cdd:cd15210  218 EVAPPVLHIIAY----VLIW-LSSCINPIIYVAMNRQYRQ 252
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
396-634 3.71e-09

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 58.33  E-value: 3.71e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 396 FLMCNLSFADFCMGLYLLLIASVDSQTKGQYYnhaidwqtGSG-CSTAGFFTVFASELSVYTLTVITLERWHTITYAIHL 474
Cdd:cd15055   37 LLLLSLAVADFLVGLLVMPFSMIRSIETCWYF--------GDTfCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLY 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 475 DQKLRLRHAILIMLGGWLFSSLIAMLPLVG---VSNYMKVSICFPmdvETTLSQVYILTILILnVVAFFIIC----ACYI 547
Cdd:cd15055  109 PTKITIRRVKICICLCWFVSALYSSVLLYDnlnQPGLIRYNSCYG---ECVVVVNFIWGVVDL-VLTFILPCtvmiVLYM 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 548 KIYFAVR-----------------NPELMATNKDTKIAKKMAILIFTDFTCMAPisFFAISAAFKVPLITVTNSKVLLVL 610
Cdd:cd15055  185 RIFVVARsqarairshtaqvslegSSKKVSKKSERKAAKTLGIVVGVFLLCWLP--YYIVSLVDPYISTPSSVFDVLIWL 262
                        250       260
                 ....*....|....*....|....
gi 106067657 611 FYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15055  263 GY-FNSCLNPLIYALFYPWFRKAL 285
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
362-630 8.01e-09

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 56.99  E-value: 8.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 362 LRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFAD-----FCMGLYLLLIASVDsqtkgqyynhaidWQTG 436
Cdd:cd15213    3 LAILMILMIFVGFLGNSIVCLIVYQKPAMRSAINLLLANLAFSDimlslVCMPFAAVTIITGR-------------WIFG 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 437 SG-CS-TAGFFTVFASElSVYTLTVITLERWHTItyaIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVS-- 512
Cdd:cd15213   70 DIfCRiSAMLYWFFVLE-GVAILLIISVDRYLII---VQRQDKLNPHRAKILIAVSWVLSFCVSFPPLVGWGKYEFPPra 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 513 -ICFPMDVETTLSQVY-ILTILILNVVAFFIICACYIKIYFAVRNPElmatnkdTKIAKKMAILIFTDFTCMAPISFFAI 590
Cdd:cd15213  146 pQCVLGYTESPADRIYvVLLLVAVFFIPFLIMLYSYFCILNTVRSFK-------TRAFTTILILFIGFSVCWLPYTVYSL 218
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 106067657 591 SAAFKVPL-ITVTNSKVLLVLFYpINSCANPFLYAIFTKTF 630
Cdd:cd15213  219 LSVFSRYSsSFYVISTCLLWLSY-LKSAFNPVIYCWRIKKF 258
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
364-634 9.09e-09

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 57.34  E-value: 9.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVdsqtkgqyYNHAIDWQTGSG-CSTA 442
Cdd:cd15051    5 VVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAI--------YELRGEWPLGPVfCNIY 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 443 GFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPL--------VGVSNYMKVSIC 514
Cdd:cd15051   77 ISLDVMLCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSFLPIhlgwntpdGRVQNGDTPNQC 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 515 fpmDVETTlsQVYILTILILnvvAFFI----ICACYIKIYFAVR----------------NPELMATNKDTKIAKKMAIL 574
Cdd:cd15051  157 ---RFELN--PPYVLLVAIG---TFYLplliMCGVYLRIFRIAReqakrinaltpastanSSKSAATAREHKATVTLAAV 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 106067657 575 IFTDFTCMAP-ISFFAISAAFKVPlITVTNSKVLLVLFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15051  229 LGAFIICWFPyFTYFTYRGLCGDN-INETALSVVLWLGY-ANSALNPILYAFLNRDFRRAF 287
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
368-634 9.51e-09

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 57.26  E-value: 9.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADF---CMGLYLLLIASVDSQTkgQYYnhaidwqtgsGCSTAGF 444
Cdd:cd14968    9 LIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADIlvgALAIPLAILISLGLPT--NFH----------GCLFMAC 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 445 FTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLs 524
Cdd:cd14968   77 LVLVLTQSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPMFGWNNGAPLESGCGEGGIQCL- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 525 qvYILTILILNVVAF----------FIICACYIKIYFAVRN----PELMATN--------KDTKIAKKMAILIFTDFTCM 582
Cdd:cd14968  156 --FEEVIPMDYMVYFnffacvlvplLIMLVIYLRIFRVIRKqlrqIESLLRSrrsrstlqKEVKAAKSLAIILFLFALCW 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 106067657 583 AP------ISFFAisAAFKVPLItVTNSKVLLVLFypiNSCANPFLYAIFTKTFQRDF 634
Cdd:cd14968  234 LPlhiincITLFC--PECKVPKI-LTYIAILLSHA---NSAVNPIVYAYRIRKFRQTF 285
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
364-634 1.09e-08

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 56.84  E-value: 1.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLInILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYL--LLIASVDSQTKGQYYNHaidwqtgsgCST 441
Cdd:cd15402    6 ILIFTI-VVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPypLVLTSIFHNGWNLGYLH---------CQI 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 442 AGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSsLIAMLPLVGVSNYMKVSICFPMDVET 521
Cdd:cd15402   76 SGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWVLT-VAAIVPNLFVGSLQYDPRIYSCTFAQ 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 522 TLSQVYILTILILN-VVAFFIICACYIKIYFAV----------RNPELmaTNKDTKIAKKMAILIFTDFTCMAPISFFAI 590
Cdd:cd15402  155 SVSSAYTIAVVFFHfILPIIIVTFCYLRIWILViqvrrrvkpdNKPKL--KPHDFRNFVTMFVVFVLFAVCWAPLNFIGL 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 106067657 591 SAAFKVPLITVTNSKVLLVLFYPI---NSCANPFLYAIFTKTFQRDF 634
Cdd:cd15402  233 AVAVDPETIVPRIPEWLFVASYYMayfNSCLNAIIYGLLNQNFRREY 279
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
369-627 1.12e-08

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 57.09  E-value: 1.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 369 INILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYllliasvdsQTKGQYYNHAIDWQTGSG--CSTAGFFT 446
Cdd:cd15388   10 IFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFF---------QVLPQLVWDITDRFRGPDvlCRLVKYLQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 447 VFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGgWLFSsLIAMLPLVGVSNYMKVS-------ICF--PM 517
Cdd:cd15388   81 VVGMFASSYMIVAMTFDRHQAICRPMVTFQKGRARWNGPVCVA-WAIS-LILSLPQVFIFSKVEVApgvyecwACFiePW 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 518 DVET----TLSQVYILTILILNVVAFFIICACYIKIY------FAVRNPELMATNKDTKIAK---------KMAILIFTD 578
Cdd:cd15388  159 GLKAyvtwITLVVFVLPTLIITVCQVLIFKEIHINIYlksqiiVAVVKKKQLLSSRASSVAEvskamiktvKMTLVIVLV 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 106067657 579 FT-CMAPisFFAIS--AAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFT 627
Cdd:cd15388  239 YVlCWAP--FFLVQlwSVWDPKAPTEGATFTILMLLASLNSCTNPWIYMAFS 288
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
360-634 1.30e-08

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 56.68  E-value: 1.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 360 DFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASvdsqtkgqYYNHAIDWQTGS-G 438
Cdd:cd15191    1 TAIPVLYSIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLFLATLPLWAT--------YYSYGYNWLFGSvM 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 439 CSTAGFFTVFASELSVYTLTVITLERWHTITYAIHlDQKLRLRHAILIMLGGWLFSSLiAMLPLVGVSN-----YMKVSI 513
Cdd:cd15191   73 CKICGSLLTLNLFASIFFITCMSVDRYLAVVYPLR-SQRRRSWQARLVCLLVWVLACL-SSLPTFYFRDtyyieELGVNA 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 514 CFPMDVETTLSQVYILTILILNVVAFFI----ICACYIKI---YFAVRNPELMATNKDtKIAKKMAILIFTDFTCMAP-- 584
Cdd:cd15191  151 CIMAFPNEKYAQWSAGLALMKNTLGFLIplivIATCYFGIgrhLLKTKGFGKNKQRRD-KVLKMVAAVVLAFLICWFPfh 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 106067657 585 -ISFFAISAAFKVPLITVTNSKVLLVLFYPI-----NSCANPFLYAIFTKTFQRDF 634
Cdd:cd15191  230 vLTFLDALARMGVINNCWVITVIDKALPFAIclgfsNSCINPFLYCFVGNHFREKL 285
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
364-634 1.38e-08

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 56.89  E-value: 1.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFcmglyLLLIASVdsQTKGQYYNHAiDWQTGS-GCSTA 442
Cdd:cd15927    5 ILFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDL-----LLLLTCV--PFTSTIYTLD-SWPFGEfLCKLS 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 443 GFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVG-------VSNYMKVSICF 515
Cdd:cd15927   77 EFLKDTSIGVSVFTLTALSADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAIPEAIFshvvtftLTDNQTIQICY 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 516 PMDVETTLSQVYILTI---LILNVVAFFIICACYIKI----YFAVRNP---ELMATNKDTKIAKKMAI------LIFtdF 579
Cdd:cd15927  157 PYPQELGPNYPKIMVLlrfLVYYLIPLLIIGVFYVLMarhlIRSTRNIgsgQNQAAQRQIEARKKVAKtvlafvVLF--A 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 106067657 580 TCMAPIS------FFAISAAFKVPLITVTNSKVLLVLFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15927  235 VCWLPRHvfmlwfHFAPNGLVDYNAFWHVLKIVGFCLSF-INSCVNPVALYLLSGSFRRHF 294
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
368-634 1.43e-08

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 56.23  E-value: 1.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLI-ASVdsQTKGQyynhaidWQTGSG-CSTAGFF 445
Cdd:cd15066    8 LIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFnASV--EITGR-------WMFGYFmCDVWNSL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 446 TVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLP----LVGVSNYMKVSICFPMDVET 521
Cdd:cd15066   79 DVYFSTASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISFLPiflgWYTTEEHLQYRKTHPDQCEF 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 522 TLSQVYILtilILNVVAFFIIC----ACYIKIYfavrnpeLMAtNKDTKIAKKMAILIFTDFTCMAPISFFAIS-----A 592
Cdd:cd15066  159 VVNKIYAL---ISSSVSFWIPCivmiFTYYRIY-------LEA-KREHKAAKTLGIIMGAFILCWLPFFLWYVTttlcgD 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 106067657 593 AFKVPLITVTnskvllVLFYP--INSCANPFLYAIFTKTFQRDF 634
Cdd:cd15066  228 ACPYPPILVS------ILFWIgyFNSTLNPLIYAYFNRDFREAF 265
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
369-634 1.63e-08

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 56.28  E-value: 1.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 369 INILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVdsqtkgqyYNHAIDWQTGSG-CSTAGFFTV 447
Cdd:cd15050   10 ISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIV--------YLLESKWILGRPvCLFWLSMDY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 448 FASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSsLIAMLPLVGVSNYMKV--SICFPMDVETTLSQ 525
Cdd:cd15050   82 VASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLS-FLWVIPILGWHHFARGgeRVVLEDKCETDFHD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 526 VYILTIL--ILNVVAFFIICAC-YIKIYFAVrnpelmatNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVT 602
Cdd:cd15050  161 VTWFKVLtaILNFYIPSLLMLWfYAKIFKAV--------NRERKAAKQLGFIMAAFILCWIPYFILFMVIAFCKNCCNEN 232
                        250       260       270
                 ....*....|....*....|....*....|..
gi 106067657 603 NSKVLLVLFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15050  233 LHMFTIWLGY-INSTLNPFIYPLCNENFKKTF 263
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
362-634 1.73e-08

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 56.10  E-value: 1.73e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 362 LRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLyLLLIASVDSQTKGQYYNHAIdWqtgsgCST 441
Cdd:cd15323    3 LAAVVGFLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVAT-LVMPFSLANELMGYWYFGQV-W-----CNI 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 442 AGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSIcFPMdVET 521
Cdd:cd15323   76 YLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLISMYRDPEGDV-YPQ-CKL 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 522 TLSQVYILTILIlnvVAFFIICACYIKIYFAVRNpelMATNKDTKIAKKMAILIFTDFTCMAPIsFFAIS------AAFK 595
Cdd:cd15323  154 NDETWYILSSCI---GSFFAPCLIMILVYIRIYR---VAKAREKRFTFVLAVVMGVFVVCWFPF-FFSYSlygicrEACE 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 106067657 596 VPlitvtnsKVLLVLFYPI---NSCANPFLYAIFTKTFQRDF 634
Cdd:cd15323  227 VP-------EPLFKFFFWIgycNSSLNPVIYTIFNQDFRRSF 261
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
364-634 1.76e-08

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 56.37  E-value: 1.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKL--TVPRFLMcNLSFADFCMGLYLL----LIASVDsqtkgqyynhaiDWQTGS 437
Cdd:cd15097    5 VVFSLIFLLGTVGNSLVLAVLLRSGQSGhnTTNLFIL-NLSVADLCFILFCVpfqaTIYSLE------------GWVFGS 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 438 G-CSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIA--MLPLVGVSNYMKVSIC 514
Cdd:cd15097   72 FlCKAVHFFIYLTMYASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAgpYLSYYDLIDYANSTVC 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 515 FPMDVETTLSQVYILTILILNVVAFFIICACYIK----IYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAI 590
Cdd:cd15097  152 MPGWEEARRKAMDTCTFAFGYLIPVLVVSLSYTRtikyLWTAVDPLEAMSESKRAKRKVTKMIIIVTALFCLCWLPHHVV 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 106067657 591 SAAF---KVPLITVTNSKVLL--VLFYPiNSCANPFLYAIFTKTFQRDF 634
Cdd:cd15097  232 ILCYlygDFPFNQATYAFRLLshCMAYA-NSCLNPIVYALVSKHFRKGF 279
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
62-198 1.94e-08

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 53.32  E-value: 1.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657   62 KVIPSQAFRGLNeVIKIEISqiDSLERIEANAFDNLLNLSEILIQNtkNLRYIEPGAFINLPrLKYLSIcNTGIRKFPDv 141
Cdd:pfam13306   1 TSIGSYAFYNCS-LTSITIP--SSLTSIGEYAFSNCTSLKSITLPS--SLTSIGSYAFYNCS-LTSITI-PSSLTSIGE- 72
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 106067657  142 tKVFSSESNfILEICDNLHITTIPGNAFQGMNNESVTLklyGNGFEEVQSHAFNGTT 198
Cdd:pfam13306  73 -YAFSNCSN-LKSITLPSNLTSIGSYAFSNCSLKSITI---PSSVTTIGSYAFSNCS 124
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
364-634 2.10e-08

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 56.07  E-value: 2.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLInILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLY---LLLIASVDSqtkgqyynhaiDWQTGS-GC 439
Cdd:cd15401    6 VLIFTI-VVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYpypLILLAIFHN-----------GWTLGNiHC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 STAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFsSLIAMLPLVGVSNYMKVSICFPMDV 519
Cdd:cd15401   74 QISGFLMGLSVIGSVFNITAIAINRYCYICHSLRYDKLYNMKKTCCYVCLTWVL-TLAAIVPNFFVGSLQYDPRIYSCTF 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 520 ETTLSQVYILTILILN-VVAFFIICACYIKIYFAV--------RNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAI 590
Cdd:cd15401  153 AQTVSSSYTITVVVVHfIVPLSIVTFCYLRIWVLViqvkhrvrQDSKQKLKANDIRNFLTMFVVFVLFAVCWGPLNFIGL 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 106067657 591 SAAFKVPLITVTNSKVLLVLFYPI---NSCANPFLYAIFTKTFQRDF 634
Cdd:cd15401  233 AVAINPLKVAPKIPEWLFVLSYFMayfNSCLNAVIYGVLNQNFRKEY 279
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
364-634 2.24e-08

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 55.94  E-value: 2.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLInILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLY---LLLIAsvdsqtkgQYYNhaiDWQTGS-GC 439
Cdd:cd15209    6 VLIVTI-VVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYpypLILHA--------IFHN---GWTLGQlHC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 STAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSsLIAMLPLVGVSNYMKVSICFPMDV 519
Cdd:cd15209   74 QASGFIMGLSVIGSIFNITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWLLT-VLAVLPNFFIGSLQYDPRIYSCTF 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 520 ETTLSQVYILTILILN-VVAFFIICACYIKIY---FAVRNPELMATNKDTKIAK----KMAILIFTDFT-CMAPISFFAI 590
Cdd:cd15209  153 AQTVSTVYTITVVVIHfLLPLLIVSFCYLRIWvlvLQVRQRVKPDQRPKLKPADvrnfLTMFVVFVLFAvCWAPLNFIGL 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 106067657 591 SAAFKVPLITVTNSKVLLVLFYPI---NSCANPFLYAIFTKTFQRDF 634
Cdd:cd15209  233 AVAINPKEMAPKIPEWLFVASYFMayfNSCLNAIIYGLLNQNFRKEY 279
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
361-634 2.58e-08

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 55.43  E-value: 2.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLyLLLIASVDSQTKGQYYNHAIdWqtgsgCS 440
Cdd:cd15059    2 AISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGL-LIMPFSLVNELMGYWYFGSV-W-----CE 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 441 TAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMdVE 520
Cdd:cd15059   75 IWLALDVLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLPPLFGWKDEQPWHGAEPQ-CE 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 521 TTLSQVYILTILILnvvAFFIIC----ACYIKIYFAVRNPELMATnkdtkiaKKMAILIFTDFTCMAPisFFaisaaFKV 596
Cdd:cd15059  154 LSDDPGYVLFSSIG---SFYIPLlimiIVYARIYRAAKRKERRFT-------LVLGVVMGAFVLCWLP--FF-----FTY 216
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 106067657 597 PLITVTN----SKVLLVLFYPI---NSCANPFLYAIFTKTFQRDF 634
Cdd:cd15059  217 PLVVVCKtcgvPELLFKFFFWLgycNSALNPVIYTIFNKDFRRAF 261
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
366-631 2.74e-08

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 55.68  E-value: 2.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 366 IWLINILAIMGNMTVLFVLLTSRYK-LTVP-RFLMCNLSFADFCMGLYLLLIaSVDSQTKGQY-YNHAIdwqtgsgCSTA 442
Cdd:cd15081   17 VWMIFVVFASVFTNGLVLVATLKFKkLRHPlNWILVNLAIADLGETVIASTI-SVVNQIFGYFiLGHPM-------CVLE 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 443 GFFTVFASELSVYTLTVITLERWHTITYA---IHLDQKLrlrhAILIMLGGWLFSSLIAMLPLVGVSNY----MKVSiCF 515
Cdd:cd15081   89 GFTVSVCGITGLWSLTIISWERWVVVCKPfgnIKFDGKL----AIVGIIFSWVWSAVWCAPPIFGWSRYwphgLKTS-CG 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 516 PmDVETTLS----QVYILTILILN-VVAFFIICACYIKIYFAVR-----NPELMATNKDTKIAKKMAI-LIFTDFTCMAP 584
Cdd:cd15081  164 P-DVFSGSSdpgvQSYMIVLMITCcIIPLAIIILCYLQVWLAIRavaqqQKESESTQKAEKEVSRMVVvMIFAYCFCWGP 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 106067657 585 ISFFAISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQ 631
Cdd:cd15081  243 YTFFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQFR 289
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
365-625 3.34e-08

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 55.54  E-value: 3.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 365 LIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQyynhaidWQTGS-GCSTAG 443
Cdd:cd15212    6 VLLAIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRPG-------WLFGDrLCLANG 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 444 FFTVFASELSVYTLTVITLERWHTItyaIHLDQ-KLRLRHAILIMLGGWLFSSLIA----ML----PLVGVSNYMKVSIC 514
Cdd:cd15212   79 FFNACFGIVSTLTMTLISFDRYYAI---VRQPQgKIGRRRALQLLAAAWLTALGFSlpwyLLasapEYYEKLGFYHCLYV 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 515 FPMDVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPE-----------LMATNKDTKIAKKMAILIFTDFTCMA 583
Cdd:cd15212  156 LHSGPSRLGAAYSSVLIVLCYLLPFALMCFCHYNICKTVRLSEsrvrpvttyahLLRFYSEMRTATTVLIMIVFIICCWG 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 106067657 584 PISFFAISAAFKVPLITVTNSKVLLVLFYPiNSCANPFLYAI 625
Cdd:cd15212  236 PYCLLGLVAAAGGYQFPPLMDTVAIWMAWA-NGAINPLIYAI 276
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
361-634 3.36e-08

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 55.54  E-value: 3.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLlTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASvdsqtkgqYYNHAIDWQTGSG-C 439
Cdd:cd15116    2 LSMVIYSVVFVLGVLGNGLVIFIT-GFKMKKTVNTVWFLNLAVADFLFTFFLPFSIA--------YTAMDFHWPFGRFmC 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 STAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWL----FSSLIAMLPLVGVSNYMKVSICF 515
Cdd:cd15116   73 KLNSFLLFLNMFTSVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVvaffLSSPSFIFRDTAPSQNNNKIICF 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 516 -------------PMDVETTLSQVYILTILILN-VVAFFIICACYIKIYFAVRNPELMATNKDTKIakkMAILIFTDFTC 581
Cdd:cd15116  153 nnfslsgdnsspeVNQLRNMRHQVMTITRFLLGfLIPFTIIICCYAAIVLKLKRNRLAKSSKPFKI---IAAVIVTFFLC 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 582 MAPISFFAIsaafkVPLITVTNSKVLLVLFYPI-------NSCANPFLYAIFTKTFQRDF 634
Cdd:cd15116  230 WAPYHILNL-----LEMEATRSPASVFKIGLPItsslafiNSCLNPILYVFMGQDFKKFK 284
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
364-634 4.06e-08

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 55.11  E-value: 4.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRY--KLTVPRFLMCNLSFADFCMGLYLLLIASVdSQTKGQyynhaidWQTGSG-CS 440
Cdd:cd15002    4 ILLGVICLLGFAGNLMVIGILLNNARkgKPSLIDSLILNLSAADLLLLLFSVPFRAA-AYSKGS-------WPLGWFvCK 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 441 TAGFFTVFASELSVYTLTVITLERWHTI-----TYAIHLDQKLRLRHAIlimlggWLFSSLIAmLP------LVGVSNYM 509
Cdd:cd15002   76 TADWFGHACMAAKSFTIAVLAKACYMYVvnptkQVTIKQRRITAVVASI------WVPACLLP-LPqwlfrtVKQSEGVY 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 510 KVSICFPMDVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKK----MAILIFTDFTCM--- 582
Cdd:cd15002  149 LCILCIPPLAHEFMSAFVKLYPLFVFCLPLTFALFYFWRAYGQCQRRGTKTQNLRNQIRSRklthMLLSVVLAFTILwlp 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 106067657 583 ---APISFFAISAAFKVPLITVTNSKVLLVLfypINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15002  229 ewvAWLWLIHIKSSGSSPPQLFNVLAQLLAF---SISSVNPIIFLLMSEEFREGF 280
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
368-634 5.03e-08

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 55.19  E-value: 5.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADfcmglyllLIASVDSQTKGQYYNHAIDWQTGSG-CSTAGFFT 446
Cdd:cd15056    9 LVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVAD--------LLVAVLVMPFGAIELVNNRWIYGETfCLVRTSLD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 447 VFASELSVYTLTVITLERWHTITyAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYM----KVSICFPMDVETT 522
Cdd:cd15056   81 VLLTTASIMHLCCIALDRYYAIC-CQPLVYKMTPLRVAVMLGGCWVIPTFISFLPIMQGWNHIgiedLIAFNCASGSTSC 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 523 LSQVYILTILILNVVAFFI----ICACYIKIYFAVRN-----------------PELMATNK---DTKIAKKMAILIFTD 578
Cdd:cd15056  160 VFMVNKPFAIICSTVAFYIpallMVLAYYRIYVAAREqahqirslqragssnheADQHRNSRmrtETKAAKTLGIIMGCF 239
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 579 FTCMAPisFFAISAAfkVPLITVTNS----KVLLVLFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15056  240 CVCWAP--FFVTNIV--DPFIGYRVPyllwTAFLWLGY-INSGLNPFLYAFFNKSFRRAF 294
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
365-634 7.70e-08

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 54.60  E-value: 7.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 365 LIW-LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFAD---------FCMGLYLLLiasvdsqtkgqyynhaiDWQ 434
Cdd:cd15095    5 LIFaIIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDlaflvccvpFTAALYATP-----------------SWV 67
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 435 TG-SGCSTAGFF---TVFASELsvyTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSL--IAMLPLVGV-SN 507
Cdd:cd15095   68 FGdFMCKFVNYMmqvTVQATCL---TLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLlsIPVAIYYRLeEG 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 508 YMK--VSICFPMDVETTLSQVYIL-TILILNVVAFFIICACYIKIYFAVRNPELM-----------ATNKDTKIAKKMA- 572
Cdd:cd15095  145 YWYgpQTYCREVWPSKAFQKAYMIyTVLLTYVIPLAIIAVCYGLILRRLWRRSVDgnnqseqlserALRQKRKVTRMVIv 224
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 106067657 573 -ILIFTdfTCMAPIS----FFAISAAFKVPLITVTNSKVLLVLFYPiNSCANPFLYAIFTKTFQRDF 634
Cdd:cd15095  225 vVVLFA--ICWLPNHvlnlWQRFDPNFPETYATYALKIAALCLSYA-NSAVNPFVYAFMGENFRKYF 288
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
359-631 8.66e-08

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 54.38  E-value: 8.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 359 YDFLRVLIWLINILAIMGNMTVLFVLLTSRYK-LTVPRFLMCNLSFADFCMGLYLLLIASvdsqtkgqYYNHAIDWQTGS 437
Cdd:cd15190   10 YALIPVIYMLVFVLGLSGNGLVLWTVFRSKRKrRRSADTFIANLALADLTFVVTLPLWAV--------YTALGYHWPFGS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 438 G-CSTAGFFTVFASELSVYTLTVITLERWHTITYAIHlDQKLRLRHAILIMLGG-WLFSSLIAMLPLV-----GVSNYMK 510
Cdd:cd15190   82 FlCKLSSYLVFVNMYASVFCLTGLSFDRYLAIVRSLA-SAKLRSRTSGIVALGViWLLAALLALPALIlrttsDLEGTNK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 511 VsICFpMD---VETTLSQVY------ILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKM----AILIFT 577
Cdd:cd15190  161 V-ICD-MDysgVVSNESEWAwiaglgLSSTVLGFLLPFLIMLTCYFFIGRTVARHFSKLRRKEDKKKRRLlkiiITLVVT 238
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 106067657 578 DFTCMAPISFF-AISAAFKVPLITVTNS-KVLLVLFYP-------INSCANPFLYAIFTKTFQ 631
Cdd:cd15190  239 FALCWLPFHLVkTLYALMYLGILPFSCGfDLFLMNAHPyatclayVNSCLNPFLYAFFDPRFR 301
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
366-632 8.78e-08

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 54.40  E-value: 8.78e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 366 IWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIAsvdsQTKGQYYNhaidWQTGSG-CSTAGF 444
Cdd:cd15189    7 IFSLCLFGLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAADLVFVSGLPFWA----MNILNQFN----WPFGELlCRVVNG 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 445 FTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIA--MLPLVGVSNYMKVSICFPMDVETT 522
Cdd:cd15189   79 VIKVNLYTSIYLLVMISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGLLLSipTFLLRKIKAIPDLNITACVLLYPH 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 523 LSQvYILTILILNVVAFF----IICACYIKIYFAVRNPELMATNKDTKIAKKMAI---LIFTDFTCMAPISFFA------ 589
Cdd:cd15189  159 EAW-HFAHIVLLNIVGFLlpllVITFCNYNILQALRTREESTRCEDRNDSKATALvlaVTLLFLVCWGPYHFFTfldflf 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 106067657 590 ----ISAAFKVPLITVTNSkvLLVLFYPINSCANPFLYAIFTKTFQR 632
Cdd:cd15189  238 dvgvLDECFWEHFIDIGLQ--LAVFLAFSNSCLNPVLYVFVGRYFRR 282
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
364-634 9.97e-08

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 54.04  E-value: 9.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFcmgLYLLLIASVDSQTKGQYynhaidWQTGSG-CSTA 442
Cdd:cd15974    5 VIYLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADE---LFMLGLPFLATQNAISY------WPFGSFlCRLV 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 443 GFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAmLPLVGVSNYMK------VSICFP 516
Cdd:cd15974   76 MTVDGVNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVV-LPVIIFSDVQPdlntcnISWPEP 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 517 MDVETTlsqVYILTILILNVVA-FFIICACYIKIYFAVRNPELMATN----KDTKIAKKMAILIFTDFT-CMAPISFFAI 590
Cdd:cd15974  155 VSVWST---AFIIYTAVLGFFGpLLVICLCYLLIVIKVKSSGLRVGStkrrKSERKVTRMVVIIVVVFVfCWLPFYMLNI 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 106067657 591 -SAAFKVPLITVTNSKVLLVLFYP-INSCANPFLYAIFTKTFQRDF 634
Cdd:cd15974  232 vNLIVILPEEPAFVGVYFFVVVLSyANSCANPILYGFLSDNFKQSF 277
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
364-634 1.13e-07

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 53.65  E-value: 1.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIdwqtgsgCSTAG 443
Cdd:cd15062    5 VALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIF-------CDVWA 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 444 FFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNymkvsicfPMDVETTL 523
Cdd:cd15062   78 AVDVLCCTASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIGPLLGWKE--------PAPADEQA 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 524 SQVY--ILTILILNVVAFF----IICACYIKIYFAVrnpelMATNKDTKIAKKMAILIFTDFTCMAPISF-FAISAAFKV 596
Cdd:cd15062  150 CGVNeePGYVLFSSLGSFYlplaIILVMYCRVYVVA-----FKFSREKKAAKTLGIVVGAFVLCWFPFFVvLPLGSLFST 224
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 106067657 597 PLITVTNSKVLLVLFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15062  225 LKPPEPVFKVVFWLGY-FNSCLNPIIYPCSSREFKRAF 261
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
368-634 1.16e-07

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 54.12  E-value: 1.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGqyynhaidWQTGSG-CSTAGFFT 446
Cdd:cd15980    9 LIFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLLDNIIAG--------WPFGSTvCKMSGMVQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 447 VFASELSVYTLTVITLERWHTITYAihLDQKLRLRHAILIMLGGWLFSSLI----AMLPLVGVSNYMKVSI--------- 513
Cdd:cd15980   81 GISVSASVFTLVAIAVDRFRCIVYP--FKQKLTISTAVVIIVIIWVLAIAImcpsAVMLHVQEEKNYRVVLgsqnktspv 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 514 --CFPMDVETTLSQVYIlTILILNV--VAFFIICACYIKIYFAVRNPELMATNKDTKIAK-----------KMAILIFTD 578
Cdd:cd15980  159 ywCREDWPNQEMRKIYT-TVLFANIylAPLSLIVIMYARIGITLFKTAMPHTGKHNQEQRhvvsrkkqkviKMLLIVALL 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 106067657 579 FTcMAPISFFAISAAFKVPLITVTNSKVLLVLFYPI-------NSCANPFLYAIFTKTFQRDF 634
Cdd:cd15980  238 FI-LSWLPLWTLMMLSDYANLSPNQLQIINIYIYPFahwlaffNSSVNPIIYGFFNENFRRGF 299
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
364-634 1.20e-07

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 53.39  E-value: 1.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRyKLTVP-RFLMCNLSFADFCMGLYLLLIA----SVDSQTKGqYYNHAIDWQTGSG 438
Cdd:cd15335    5 LTLALITILTTVLNSAVIAAICTTK-KLHQPaNYLICSLAVTDFLVAVLVMPLSityiVMDTWTLG-YFICEIWLSVDMT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 439 CSTAgfftvfaselSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKvsicfPMD 518
Cdd:cd15335   83 CCTC----------SILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIFISIPPLFWRNHHDA-----NIP 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 519 VETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNpelmATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPL 598
Cdd:cd15335  148 SQCIIQHDHVIYTIYSTFGAFYIPLTLILILYYRIYH----AASRERKAARILGLILGAFILSWLPFFIKELIVGLSVMT 223
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 106067657 599 ITVTNSKVLLVLFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15335  224 VSPEVADFLTWLGY-VNSLVNPLLYTSFNEDFKLAF 258
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
371-633 1.68e-07

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 53.28  E-value: 1.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 371 ILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVdsqtkgqyYNHAIDWQTGSG-CSTAGFFTVFA 449
Cdd:cd15395   12 ILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTIMCLPFTFV--------YTLMDHWVFGEAmCKLNSMVQCIS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 450 SELSVYTLTVITLERWHTITYAihLDQKLRLRHAILIMLGGWLFSSLIAM--------------LPLVGVSNYMKVSICF 515
Cdd:cd15395   84 ITVSIFSLVLIAIERHQLIINP--RGWRPNNRHAYVGIAVIWVLAVLTSLpflifqvltdepfkNVNVSLDAYKGKYVCL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 516 PMDVETTLSQVYILTILILNVVA-FFIICACYIKIYFAV--RNP--ELMATNK----DTKIAKKMAILIFTDFT-CMAPI 585
Cdd:cd15395  162 DQFPSDTIRLSYTTCLLVLQYFGpLCFIFICYLKIYIRLkrRNNmmDKMRDNKyrssETKRINIMLISIVVAFAvCWLPL 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 106067657 586 SFFAISAAFKVPLITVTNSKVLLVLFY---PINSCANPFLYAIFTKTFQRD 633
Cdd:cd15395  242 NIFNAVFDWNHEAIATCNHNLLFLICHltaMISTCVNPIFYGFLNKNFQRD 292
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
372-634 2.06e-07

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 53.01  E-value: 2.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 372 LAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVdsqtkgqYYNHAiDWQTGSG-CSTAGFFTVFAS 450
Cdd:cd16003   13 VAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFI-------YALHS-EWYFGEAyCRFHNFFPITSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 451 ELSVYTLTVITLERWHTItyaIH-LDQKLRLRHAILIMLGGWLFSSLIAmLPLVGVSNYMKV---SICF---PMDVETTL 523
Cdd:cd16003   85 FASIYSMTAIAVDRYMAI---IDpLKPRLSATATKVVIGSIWILAFLLA-FPQCLYSKTKVMpgrTLCFvawPGGPDQHF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 524 SQVYILTILILnVVAFFIICACYIKIYFAVRNPELMATNKDT---------KIAKKMAILIFTDFTCMAPISFFAISAAF 594
Cdd:cd16003  161 TYHIIVIVLVY-CLPLLVMGITYTIVGITLWGGEIPGDTSDKyheqlrakrKVVKMMIIVVLTFAICWLPYHIYFIVTGL 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 106067657 595 KVPLITVTN-SKVLLVLFYPINSCA--NPFLYAIFTKTFQRDF 634
Cdd:cd16003  240 YQQLNRWKYiQQVYLASFWLAMSSTmyNPIIYCCLNKRFRAGF 282
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
368-634 2.08e-07

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 53.25  E-value: 2.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFAD-----FCMGLYLLliasvdsqtkgqyYNHAIDWQTGS-GCST 441
Cdd:cd15205    9 LIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDllitfFCIPFTLL-------------QNISSNWLGGAfMCKM 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 442 AGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAIlIMLGGWLFSSLIAMLPLVGVSN--------YMKVSI 513
Cdd:cd15205   76 VPFVQSTAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAF-TMLGLVWIVSVIVGSPMLFVQQlevkydflYEKRHV 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 514 CFpmdVETTLSQVYILTILILNVVAFFII-----CACYIKIYFA--VRNP----ELMATNKDTKIAK---------KMAI 573
Cdd:cd15205  155 CC---LERWYSPTQQKIYTTFILVILFLLplttmLFLYSRIGYElwIKKRvgdaSVLQTIHGIEMSKisrkkkravKMMV 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 106067657 574 LIFTDFT-CMAP-------ISFFAISAAFKVPLITVTNSKVLLVLFYpiNSCANPFLYAIFTKTFQRDF 634
Cdd:cd15205  232 TVVLLFAvCWAPfhvvhmmIEYSNLENKYDGVTIKLIFAIVQLIGFS--NSFNNPIVYAFMNENFKKNF 298
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
368-634 2.35e-07

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 52.72  E-value: 2.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYllliaSVDSQTKGQYYNHaidWQTGS-GCSTAGFFT 446
Cdd:cd15300    9 VVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIF-----SMNLYTSYILMGY---WALGSlACDLWLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 447 VFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSsLIAMLPLVGVSNYMKVSICFPMDvETTLSQV 526
Cdd:cd15300   81 YVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLIS-FILWAPPILCWQYFVGKRTVPER-ECQIQFL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 527 YILTILILNVVAFFIICACYIKIYFAVRNPElmaTNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKV 606
Cdd:cd15300  159 SEPTITFGTAIAAFYIPVSVMTILYCRIYKE---TIKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCSDCIPLTLWHL 235
                        250       260
                 ....*....|....*....|....*...
gi 106067657 607 LLVLFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15300  236 GYWLCY-VNSTVNPMCYALCNKTFRKTF 262
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
368-634 2.47e-07

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 52.89  E-value: 2.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTS---RYKLTVPRFLMCNLSFADFcmgLYLLLIASVDSQTKGQYYNHAidwqTGSGCSTAGF 444
Cdd:cd15338    9 VICFLGIIGNSIVIYTIVKKskfRCQQTVPDIFIFNLSIVDL---LFLLGMPFLIHQLLGNGVWHF----GETMCTLITA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 445 FTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSL--------IAMLPLVGVSnyMKVSICFP 516
Cdd:cd15338   82 LDTNSQITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSLLsitpvwmyAGLMPLPDGS--VGCALLLP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 517 mDVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKD----TKIAKKMAILI-FTDFTCMAPISFFAIS 591
Cdd:cd15338  160 -NPETDTYWFTLYQFFLAFALPLVVICVVYFKILQNMASTVAPLPQRSlrvrTKKVTRMAVAIcLAFFICWAPFYILQLA 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 106067657 592 A-AFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15338  239 HlSIDRPSLAFLYAYNVAISMGYANSCINPFLYIMLSETFKRQF 282
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
361-638 2.50e-07

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 52.64  E-value: 2.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGlylllIASVDSQTKGQYYNHaidWQTGS-GC 439
Cdd:cd15299    5 LIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIG-----VISMNLFTTYIIMNR---WALGNlAC 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 STAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAiLIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDv 519
Cdd:cd15299   77 DLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRA-GVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPD- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 520 ETTLSQVYILTILILNVVAFF-----IICACYIKIYfavrnpelMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAF 594
Cdd:cd15299  155 ECFIQFLSEPIITFGTAIAAFylpvtIMTILYWRIY--------KETIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTF 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 106067657 595 KVPLITVTNSKVLLVLFYpINSCANPFLYAIFTKTFQRDFFLLL 638
Cdd:cd15299  227 CDSCIPKTYWNLGYWLCY-INSTVNPVCYALCNKTFRTTFKMLL 269
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
359-632 2.59e-07

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 52.88  E-value: 2.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 359 YDFLRVLIWLINILAIMGNMTVLFVllTSRYK-LTVP-RFLMCNLSFADFCMGLYLLLIaSVDSQTKGQYY--NHAidwq 434
Cdd:cd15082   13 FTVLAALMFVVTSLSLAENFAVMLV--TFRFKqLRQPlNYIIVNLSVADFLVSLTGGTI-SFLTNARGYFFlgVWA---- 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 435 tgsgCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHlDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSI- 513
Cdd:cd15082   86 ----CVLEGFAVTFFGIVALWSLAVLAFERFFVICRPLG-NIRLQGKHAALGLLFVWTFSFIWTIPPVLGWSSYTVSKIg 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 514 --CFPMDVETTLS-QVYILTILILN-VVAFFIICACYIKIYFAVR-----NPELMATNK-DTKIAKKMAILIFTDFTCMA 583
Cdd:cd15082  161 ttCEPNWYSGNMHdHTYIITFFTTCfILPLGVIFVSYGKLLQKLRkvsntQGRLGNARKpERQVTRMVVVMIVAFMVCWT 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 106067657 584 PISFFAISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQR 632
Cdd:cd15082  241 PYAAFSILVTAHPTIHLDPRLAAIPAFFSKTAAVYNPIIYVFMNKQFRK 289
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
364-634 3.00e-07

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 52.55  E-value: 3.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIwLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLY---LLLIASvdsqtkgqYYNhaiDWQTGS-GC 439
Cdd:cd15400    6 VLI-FTTVVDILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYpypLVLVAI--------FHN---GWALGEmHC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 STAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFsSLIAMLP--LVGVSNY-MKVSICfp 516
Cdd:cd15400   74 KVSGFVMGLSVIGSIFNITGIAINRYCYICHSFAYDKLYSRWNTLLYVCLIWAL-TVVAIVPnfFVGSLEYdPRIYSC-- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 517 MDVETTLSQVYILTILILNVVAFFIICACYIKIYFAV------RNPELMATNKDTKIAKKMAI-LIFTDFT-CMAPISFF 588
Cdd:cd15400  151 TFVQTASSSYTIAVVVIHFIVPITVVSFCYLRIWVLViqvrrkVKSESKPRLKPSDFRNFLTMfVVFVIFAiCWAPLNLI 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 106067657 589 AISAAFKVPLITVTNSKVLLVLFYPI---NSCANPFLYAIFTKTFQRDF 634
Cdd:cd15400  231 GLAVAINPQEMAPKVPEWLFVVSYFMayfNSCLNAIIYGLLNQNFRKEY 279
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
371-634 3.23e-07

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 52.64  E-value: 3.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 371 ILAIMGNMTVLFVLLTSRYKLTVPRFLMCnLSFADFCMGLYLLLIASVDSQTKgqYYNHAIDWQTGSGCSTAGFFTVFAS 450
Cdd:cd14978   12 IFGIIGNILNLVVLTRKSMRSSTNVYLAA-LAVSDILVLLSALPLFLLPYIAD--YSSSFLSYFYAYFLPYIYPLANTFQ 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 451 ELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAmLP----------LVGVSNYMKVSICFPMDVE 520
Cdd:cd14978   89 TASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLN-LPrffeyevvecENCNNNSYYYVIPTLLRQN 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 521 TTLSQVY--ILTILILNVVAFFIICACYIKIYFAVRNPELMATN-------------KDTKIAKKMAILIFTDFTCMAPI 585
Cdd:cd14978  168 ETYLLKYyfWLYAIFVVLLPFILLLILNILLIRALRKSKKRRRLlrrrrrllsrsqrRERRTTIMLIAVVIVFLICNLPA 247
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 106067657 586 SFFAISAAFKVP---------LITVTNskvLLVLfypINSCANPFLYAIFTKTFQRDF 634
Cdd:cd14978  248 GILNILEAIFGEsflspiyqlLGDISN---LLVV---LNSAVNFIIYCLFSSKFRRTF 299
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
368-634 3.55e-07

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 52.54  E-value: 3.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVdsqtkgqYYNHAiDWQTGSG-CSTAGFFT 446
Cdd:cd16004    9 LIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFV-------YASHN-DWYFGLEfCRFQNFFP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 447 VFASELSVYTLTVITLERWHTItyaIHLDQKLRLRHAILIMLGG-WLFSSLIAMLP--LVGVSNYMKVSIC---FPMDVE 520
Cdd:cd16004   81 ITAMFVSIYSMTAIAADRYMAI---IHPFKPRLSAGSTKVVIAGiWLVALALAFPQcfYSTVTMDQGRTKCivaWPGDSG 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 521 TTLSQVY-ILTILILNVVAFFIICACYIKIYF----------AVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFA 589
Cdd:cd16004  158 GKHQLTYhLAVIVLIYLLPLAVMFVTYSIIGItlwrsavpghQAHGAYHRQLQAKKKFVKTMVVVVVTFAICWLPYHLYF 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 106067657 590 ISAAFKVPLITVTN-SKVLLVLFYPINSCA--NPFLYAIFTKTFQRDF 634
Cdd:cd16004  238 ILGSFNEDIYCQKYiQQVYLAIFWLAMSSTmyNPIIYCCLNQRFRSGF 285
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
364-634 4.21e-07

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 51.99  E-value: 4.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYK-LTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIdwqtgsgCSTA 442
Cdd:cd15104    4 VILAVLSPLIITGNLLVIVALLKLIRKkDTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVL-------CLLR 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 443 GFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVgvsnymkvsicFPMDVETT 522
Cdd:cd15104   77 MCFVITSCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGFLPLI-----------SPQFQQTS 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 523 LS-----------QVYILTILILNVVAFFIICACYIKIY---------------FAVRNPELMATNKDTKIAKKMAILIF 576
Cdd:cd15104  146 YKgkcsffaafhpRVLLVLSCMVFFPALLLFVFCYCDILkiarvhsraiykvehALARQIHPRRTLSDFKAARTVAVLIG 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 106067657 577 TDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15104  226 CFLLSWLPFQITGLVQALCDECKLYDVLEDYLWLLGLCNSLLNPWIYAFWQKEVRRAL 283
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
361-634 4.33e-07

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 52.00  E-value: 4.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFcmgLYLLLIASVDsqtkgQYYNHAIDWQTGS-GC 439
Cdd:cd15375    2 YLPVMYSIIFIVGFPGNIIAIFVYLFKMRPWKSSTIIMLNLALTDL---LYVTSLPFLI-----YYYINGESWIFGEfMC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 STAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSsLIAMLPLVGVSNYMKV---SICFP 516
Cdd:cd15375   74 KFIRFIFHFNLYGSILFLTCFSIFRYVVIVHPLRAFQVQKRRWAIVACAVVWVIS-LAEVSPMTFLITTKEKnnrTICLD 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 517 MDVETTLSQVYILTiLILNVVAFF----IICACYIKIYFAVRNPELMATNKDTKiAKKMAILIFTDFT-CMAPISFF-AI 590
Cdd:cd15375  153 FTSSDNLNTIWWYN-WILTVLGFLlplvIVTLCYTRIIYTLAKGPHTGSASKQK-ARRLIILILLVFYvCFLPFHILrVV 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 106067657 591 SAAFKVPLITVTNSKVLLVLFY---PI---NSCANPFLYAIFTKTFQRDF 634
Cdd:cd15375  231 RIETRLPPVSCCLKHQVHAIYIitrPLaalNTFGNLLLYVVSGDNFQQAF 280
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
365-634 4.44e-07

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 51.88  E-value: 4.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 365 LIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADfCMGLYLLLIASVDSQTKGQyynhaiDWQTG-SGCSTAG 443
Cdd:cd15328    6 LLAMLVVATFLWNLLVLVTILRVRTFHRVPHNLVASMAVSD-VLVAALVMPLSLVHELSGR------RWQLGrSLCQVWI 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 444 FFTVFASELSVYTLTVITLERWHTITYaiHLDQKLRLRHAI--LIMLGGWLFSSLIAMLPLV--------GVSNYMKVSI 513
Cdd:cd15328   79 SFDVLCCTASIWNVTAIALDRYWSITR--HLEYTLRTRRRIsnVMIALTWALSAVISLAPLLfgwgetysEDSEECQVSQ 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 514 CFPMDVETTLSQVYiltiLILNVVAFfiicaCYIKIYfavrnpelMATNKDTKIAKKMAILIFTDFTCMAPisFFAisAA 593
Cdd:cd15328  157 EPSYTVFSTFGAFY----LPLCVVLF-----VYWKIY--------KAAQKEKRAALMVGILIGVFVLCWIP--FFL--TE 215
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 106067657 594 FKVPL----ITVTNSKVLLVLFYPiNSCANPFLYAIFTKTFQRDF 634
Cdd:cd15328  216 LISPLcscdIPPIWKSIFLWLGYS-NSFFNPLIYTAFNKNYNNAF 259
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
364-634 4.47e-07

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 51.86  E-value: 4.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLF-VLLTSRYKLTVPRFLMcNLSFADFCMGLYLLLIASVDSQtkgqyynHAIDWQTGSG-CST 441
Cdd:cd15304    5 LLTVIVIILTIAGNILVIMaVSLEKKLQNATNYFLM-SLAIADMLLGFLVMPVSMLTIL-------YGYRWPLPSKlCAV 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 442 AGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAM-LPLVGVSNYMKV---SICFPM 517
Cdd:cd15304   77 WIYLDVLFSTASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISMpIPVFGLQDDSKVfkeGSCLLA 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 518 DVETtlsqvyiltILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPisfFAISAAFKVP 597
Cdd:cd15304  157 DENF---------VLIGSFVAFFIPLTIMVITYFLTIKSLQQSISNEQKASKVLGIVFFLFVVMWCP---FFITNVMAVI 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 106067657 598 LITVTNSKV---LLVLFYPI---NSCANPFLYAIFTKTFQRDF 634
Cdd:cd15304  225 CKESCNEVViggLLNVFVWIgylSSAVNPLVYTLFNKTYRSAF 267
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
360-632 4.57e-07

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 51.93  E-value: 4.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 360 DFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYL-LLIASvdsqtkgqYYNHAiDWQTGSG 438
Cdd:cd15168    1 IFLPIVYGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLLSLpFLIYY--------YANGD-HWIFGDF 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 439 -CSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWL--FSSLIAMLPLVGVSNYMKVSICF 515
Cdd:cd15168   72 mCKLVRFLFYFNLYGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWIlvLLQLLPILFFATTGRKNNRTTCY 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 516 ----PMDVETTLSQVYILTILiLNVVAFFIICACYIKIYFAV--RNPELMATNKDTKIAkKMAILIFTDFT-CMAPisfF 588
Cdd:cd15168  152 dttsPEELNDYVIYSMVLTGL-GFLLPLLIILACYGLIVRALirKLGEGVTSALRRKSI-RLVIIVLALFAvCFLP---F 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 106067657 589 AI--SAAFKVPLITVTNSKVLLVLFY----------PINSCANPFLYAIFTKTFQR 632
Cdd:cd15168  227 HVtrTINLAARLLSGTASCATLNGIYvaykvtrplaSLNSCLNPLLYFLAGDKFRR 282
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
364-634 5.15e-07

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 51.58  E-value: 5.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVdsqtkgqYYNHAIDWQTGSG-CSTA 442
Cdd:cd15053    5 LFLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVY-------VEVNGGKWYLGPIlCDIY 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 443 GFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNymkvsicfpmdVETT 522
Cdd:cd15053   78 IAMDVMCSTASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLLFGLNN-----------VPYR 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 523 LSQVYILT----ILILNVVAFFIICAC----YIKIYFAVRnpelmatnKDTKIAKKMAILIFTDFTCMAPisFFAISAAF 594
Cdd:cd15053  147 DPEECRFYnpdfIIYSSISSFYIPCIVmlllYYRIFRALR--------REKKATKTLAIVLGVFLFCWLP--FFTLNILN 216
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 106067657 595 KVPLITVTNS-KVLLVLFYP------INSCANPFLYAIFTKTFQRDF 634
Cdd:cd15053  217 AICPKLQNQScHVGPALFSLttwlgyVNSFLNPIIYTIFNIEFRKAF 263
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
368-501 5.49e-07

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 51.75  E-value: 5.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIdwqtgsgCSTAGFFTV 447
Cdd:cd15981    9 FIFLLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNAM-------CKMSGLVQG 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 106067657 448 FASELSVYTLTVITLERWHTITYAIHldQKLRLRHAILIMLGGWLFsSLIAMLP 501
Cdd:cd15981   82 MSVSASVFTLVAIAVERFRCIVHPFR--QKLTLRKAIVTIVIIWVL-ALIIMCP 132
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
361-634 6.40e-07

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 51.59  E-value: 6.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASvdsqtkgqyyNHAIDWQTGS-GC 439
Cdd:cd15182    2 FLPVFYYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLLFTFTLPFWAS----------YHSSGWIFGEiLC 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 S--TAGFFTVFASelSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVG---VSNYMKVSIC 514
Cdd:cd15182   72 KavTSIFYIGFYS--SILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISILASLPELILstvMKSDEDGSLC 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 515 FPMDVETTLSQVYILTILILnvVAFFIICACYIKIYFAVRNPELMATNKDTKIakkMAILIFTDFTCMAPISFFAISAAF 594
Cdd:cd15182  150 EYSSIKWKLGYYYQQNLFFL--IPLGIIVYCYVRILQTLMRTRTMRKHRTVKL---IFVIVLVFFLSWAPYNIVIFLRSL 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 106067657 595 KVPLITVTN-SKVLLVLFYPINS------CANPFLYAIFTKTFQRDF 634
Cdd:cd15182  225 KDLTIPICEcSKQLDYAFYICRNiafshcCLNPVFYVFVGVKFRNHL 271
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
362-632 6.56e-07

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 51.43  E-value: 6.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 362 LRVLIWLINILAIMGNMTVLFVLLTSR-YKLTVPRFLMCNLSFADFCMGLYLLLIAsvdsqtkgqyYNHAID--WQTGSG 438
Cdd:cd15926    3 ISIVYSVVCALGLVGNLLVLYLMKSKQgWKKSSINLFVTSLAVTDFQFVLTLPFWA----------VENALDftWLFGKA 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 439 -CSTAGFFTVFASELSVYTLTVITLERWHTITYAIHlDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVS---IC 514
Cdd:cd15926   73 mCKIVSYVTAMNMYASVFFLTAMSVARYHSVASALK-SKRRRGCCSAKWLCVLIWVLAILASLPNAIFSTTATVSneeLC 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 515 ---FP---MDVETTLSQVYILTILILNVVAFFIICACYIKI--YFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAP-- 584
Cdd:cd15926  152 lvkFPdnrGNAQFWLGLYHAQKVLLGFLIPLGIISLCYLLLvrFITDKNITGSSTKRRSKVTKSVTIVVLSFFLCWLPnq 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 106067657 585 -ISFFAISAAFKVPLITvTNSKVLLVLFYPI-------NSCANPFLYAIFTKTFQR 632
Cdd:cd15926  232 aLTTWGILIKLNVVHFS-YEYFTTQVYIFPItvclahsNSCLNPILYCLMRREFRK 286
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
362-634 8.84e-07

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 50.98  E-value: 8.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 362 LRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIasvdsqtkgqYYNHAID--WQTGSG- 438
Cdd:cd15295    3 LLFLMSLLALVIVLGNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAISIPL----------YIPYTLTnrWDFGRGl 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 439 CSTAGFFTVFASELSVYTLTVITLERWHTITYAI-HLDQKLRLRHAILIMLGGWLFSSLIAMlPLVGVSNYMKV--SICF 515
Cdd:cd15295   73 CVFWLVIDYLLCTASVYNIVLISYDRYQSVSNAVsYRNQQTATLRIVTQMVAVWVLAFLVHG-PAILVSDSWKTedGECE 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 516 PmdvETTLSQVYILTILILNVVAFFIICACY-IKIYFAVRNpelmaTNKDTKIAKKMAILIFTDFTCMAPISFFAISAAF 594
Cdd:cd15295  152 P---EFFSNWYILAITSVLEFLVPVILVAYFnTQIYWSLWK-----RLRDRKLAKSLAIILGTFAICWAPYSLFTIIRAA 223
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 106067657 595 KvplitvtnSKVLLVLFYPI-------NSCANPFLYAIFTKTFQRDF 634
Cdd:cd15295  224 C--------EKHRGSPWYNFafwlqwfNSFINPFLYPLCHKRFRKAF 262
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
369-634 9.38e-07

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 50.72  E-value: 9.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 369 INILAIMG---NMTVLFVLLTSRyKLTVP-RFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIdwqtgsgCSTAGF 444
Cdd:cd15334    7 LSILALMTtaiNSLVITAIIVTR-KLHHPaNYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVV-------CDIWLS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 445 FTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKvsicfpMDVETTLS 524
Cdd:cd15334   79 VDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPPLFWRHQTTS------REDECIIK 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 525 QVYILTILILNVVAFFIICACYIKIYFAVRNpelmATNKDTKIAKKMAILIFTDFTCMAPisFFAISAAFKV---PLITV 601
Cdd:cd15334  153 HDHIVFTIYSTFGAFYIPLALILILYYKIYR----AATRERKAATTLGLILGAFVICWLP--FFVKEVIVNTcdsCYISE 226
                        250       260       270
                 ....*....|....*....|....*....|...
gi 106067657 602 TNSKVLLVLFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15334  227 EMSNFLTWLGY-INSLINPLIYTIFNEDFKKAF 258
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
361-633 1.22e-06

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 50.85  E-value: 1.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIAsvdsqtkgQYYNHAIDWQTGSG-C 439
Cdd:cd15160    2 FLPVVYSFVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDLLYILTLPLWI--------DYTANHHNWTFGPLsC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 STAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWL----FSSLIAMLPLVGVSNYmKVSICF 515
Cdd:cd15160   74 KVVGFFFYTNIYASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVlelgTHSVFLGHDELFRDEP-NHTLCY 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 516 PM-DVETTLSQVYILTILILNVVAFFIICACYIKIYFAVR-NPELMATNKDtKIAKKMAILIFTDFTCMAPISF--FAIS 591
Cdd:cd15160  153 EKyPMEGWQASYNYARFLVGFLIPLSLILFFYRRVLRAVRqSPSLEREEKR-KIIGLLLSIVVIFLLCFLPYHVvlLVRS 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 106067657 592 AAFKVPLIT------VTNSKVLLVLFYPINSCANPFLYAIFTKTFQRD 633
Cdd:cd15160  232 VIELVQNGLcgfekrVFTAYQISLCLTSLNCVADPILYIFVTEDVRQD 279
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
362-634 1.62e-06

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 50.25  E-value: 1.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 362 LRVLIW-LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIdwqtgsgCS 440
Cdd:cd15978    2 VRILLYsLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAV-------CK 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 441 TAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIaMLPLVGVSNYMKVS-------- 512
Cdd:cd15978   75 TATYFMGISVSVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTI-MLPYPIYSNLVPFTrinnstgn 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 513 ---ICFPMDVetTLSQVYILTILILNVVAFFIICACY----IKIYFAVRNpeLMATNkdtKIAKKMAILIFTDFTCMAPI 585
Cdd:cd15978  154 mcrLLWPNDV--TQQSWYIFLLLILFLIPGIVMMTAYglisLELYRGIKF--LMAKK---RVIRMLIVIVILFFLCWTPI 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 106067657 586 ----SFFAISAAFKVPLITVTNSKVLLVLFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15978  227 fsanAWRAFDTRSADRLLSGAPISFIHLLSY-TSACVNPIIYCFMNKRFRMGF 278
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
362-634 1.94e-06

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 49.79  E-value: 1.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 362 LRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAI-DWQTGSG-- 438
Cdd:cd15333    7 LAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVcDIWLSSDit 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 439 CSTAgfftvfaselSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLV--GVSNYMKVSIC-- 514
Cdd:cd15333   87 CCTA----------SILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPFFwrQAKAEEEVSECvv 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 515 ----FPMDVETTLSQVYILTILILnvvaffiicACYIKIYFAVRNPELMATnkdtkiaKKMAILIFTDFTCMAPisFFAI 590
Cdd:cd15333  157 ntdhILYTVYSTVGAFYIPTLLLI---------ALYGRIYVEARARERKAT-------KTLGIILGAFIVCWLP--FFII 218
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 106067657 591 S--------AAFKVPLITvtnskVLLVLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15333  219 SlvlpickdACWFHLAIF-----DFFTWLGYLNSLINPIIYTMSNEDFKQAF 265
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
368-634 1.97e-06

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 50.33  E-value: 1.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFcmglyLLLIASVDSQTKGQYYNhaiDWQTGS-GCSTAGFFT 446
Cdd:cd15125    9 LIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDL-----LLLVTCVPVDASRYFYE---EWMFGTvGCKLIPVIQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 447 VFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAmLPLVGVSNYMKVS----------ICFP 516
Cdd:cd15125   81 LTSVGVSVFTLTALSADRYKAIVNPMDIQTSSAVLRTCLKAIAIWVVSVLLA-VPEAVFSEVAHIMpddnttftacIPYP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 517 MDVE-------TTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMA--ILIFTDF--TCMAPI 585
Cdd:cd15125  160 QTDEmhpkihsVLIFLVYFLIPLAIISIYYYHIAKTLIKSAHNIPGEYSEHSKRQMETRKRLAkiVLVFVGLfaFCWFPN 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 106067657 586 SFFAISAAFKVPLITVTNSKVLLVLFYPI----NSCANPFLYAIFTKTFQRDF 634
Cdd:cd15125  240 HVLYMYRSFNYNEIDSSLGHMIVTLVARVlsfcNSCVNPFALYLLSESFRRHF 292
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
371-629 2.14e-06

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 49.94  E-value: 2.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 371 ILAIMGNMTVLFVLLTSR--YKLTVPRFLMCNLSFADFCmGLyLLLIASVDSQtkgqyYNHAIDWQTG-SGCSTAGFFTV 447
Cdd:cd14981   12 VFGVLGNLLALIVLARSSksHKWSVFYRLVAGLAITDLL-GI-LLTSPVVLAV-----YASNFEWDGGqPLCDYFGFMMS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 448 FASELSVYTLTVITLER----WHTITYAIHLDQklrlRHAILIMLGGWLFSSLIAMLPLVGVSNYMKV---SICF-PMDV 519
Cdd:cd14981   85 FFGLSSLLIVCAMAVERflaiTHPFFYNSHVKK----RRARLMLGAVWAFALLIASLPLLGLGSYVLQypgTWCFlDFYS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 520 ETTLSQVY-----ILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKK----MAIL---IFTDFT-CMAPIS 586
Cdd:cd14981  161 KNTGDAAYaylysILGLLILLVTLLCNLLVIITLLRMRRRKKRHRRSRRSARRQKRneiqMVVLllaITVVFSvCWLPLM 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 106067657 587 FFAISAAFKvPLITVTNSKVLLVLFYPINSCANPFLYAIFTKT 629
Cdd:cd14981  241 IRVLINATG-DSEKNGKTDLLAVRMASWNQILDPWVYILLRKE 282
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
361-634 2.25e-06

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 49.83  E-value: 2.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTV-LFVLLTSRYKLTVPRFLMcNLSFADFCMGLYLLLIASVDSqtkgqYYNHaiDWQTGSG- 438
Cdd:cd15306    2 WAALLILMVIIPTIGGNILViLAVSLEKKLQYATNYFLM-SLAVADLLVGLFVMPIALLTI-----LFEA--MWPLPLVl 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 439 CSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAM-LPLVGVSNYMKVSICFPM 517
Cdd:cd15306   74 CPIWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWLISIGIAIpVPIKGIETDVDNPNNITC 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 518 DVETTLSQVYILtilILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCM-APISFFAISAAFKV 596
Cdd:cd15306  154 VLTKERFGDFIL---FGSLAAFFTPLAIMIVTYFLTIHALRKQTITNEQRASKVLGIVFFLFLLMwCPFFITNITSVLCD 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 106067657 597 PLITVTNSKVLLVLFYP--INSCANPFLYAIFTKTFQRDF 634
Cdd:cd15306  231 SCNQTTLQMLMEIFVWIgyVSSGVNPLVYTLFNKTFRDAF 270
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
361-634 2.47e-06

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 49.69  E-value: 2.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIAsVDSqtkgqyynhAIDWQTGSG-C 439
Cdd:cd15180    2 FLPVLYSLVFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILLLVTLPFWA-VQA---------VHGWIFGTGlC 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 STAG--FFTVFASelSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIA---MLPLVGVSNY-MKVSI 513
Cdd:cd15180   72 KLAGavFKINFYC--GIFLLACISFDRYLSIVHAVQMYSRKKPMLVHLSCLIVWLFCLLLSipdFIFLEATKDPrQNKTE 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 514 C---FPMDVET---TLSQVYILTILILNVVAFFIICACYIKiyfavrnpELMATNKDTKIAKKMAI---LIFTDFTCMAP 584
Cdd:cd15180  150 CvhnFPQSDTYwwlALRLLYHIVGFLLPLAVMVYCYTSILL--------RLLRSSQGFQKQRAIRVivaVVVVFFLCWTP 221
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 585 ISFFAISAAFKVPLITVTNS----------KVLLVLFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15180  222 YNIALLVDTLIDLSVLDRNCgtesrldialSVTSSLGY-FHCCLNPLLYAFVGVKFRRKL 280
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
368-632 3.12e-06

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 49.64  E-value: 3.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADfcmglylLLIASVDSQ-TKGQYYNHaiDWQTGSG-CSTAGFF 445
Cdd:cd15389    9 IIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSD-------ILITLLNTPfTLVRFVNS--TWVFGKImCHLSRFA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 446 TVFASELSVYTLTVITLERWHTITYAihLDQKLRLRHAILIMLGGWLFSSLIAM-------LPLVGVSNYMKVSIC---F 515
Cdd:cd15389   80 QYCSVYVSTLTLTAIALDRHRVILHP--LKPRITPCQGVVVIAIIWIMASCLSLphaiyqkLVEFEYSNERTRSRClpsF 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 516 PMDVETTLSQVYILTILILNVVAFFIICACYIKIYF---------AVRNPELMATNKDTKIAKKMAILIFTDFT-CMAPI 585
Cdd:cd15389  158 PEPSDLFWKYLDLATFILQYVLPLLIIGVAYTRVAKklwlrnaigDVTTEQYVAQRRKKKKTIKMLMLVVLLFAiCWLPL 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 106067657 586 SFFAISAAFKVpliTVTNSKVLLVL--FYPINSCANPFLYAIFTKTFQR 632
Cdd:cd15389  238 NCYHVLLSSHP---IRSNSALFFAFhwLAMSSTCYNPFIYCWLNDSFRS 283
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
364-634 3.28e-06

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 49.55  E-value: 3.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNhaidwqtgsGCSTAG 443
Cdd:cd15068    5 TVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACH---------GCLFIA 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 444 FFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVG-------VSNYMKVSICFP 516
Cdd:cd15068   76 CFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGwnncgqpKEGKNHSQGCGE 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 517 MDVETTLSQVYILTILILN------VVAFFIICACYIKIYFAVRN----------PELMATN---KDTKIAKKMAILIFT 577
Cdd:cd15068  156 GQVACLFEDVVPMNYMVYFnffacvLVPLLLMLGVYLRIFLAARRqlkqmesqplPGERARStlqKEVHAAKSLAIIVGL 235
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 106067657 578 DFTCMAPISFFAISAAF-----KVPLITVtnskVLLVLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15068  236 FALCWLPLHIINCFTFFcpdcsHAPLWLM----YLAIVLSHTNSVVNPFIYAYRIREFRQTF 293
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
368-498 3.36e-06

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 49.48  E-value: 3.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIdwqtgsgCSTAGFFTV 447
Cdd:cd16002    9 VIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNEWYYGLEY-------CKFHNFFPI 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 106067657 448 FASELSVYTLTVITLERWHTItyaIH-LDQKLRLRHAILIMLGGWLFSSLIA 498
Cdd:cd16002   82 AAVFASIYSMTAIALDRYMAI---IHpLQPRLSATATKVVICVIWVLAFLLA 130
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
361-634 3.72e-06

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 49.62  E-value: 3.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIwlinILAIMGNMTVLFVLLTSRY-KLTVPRFLMCNLSFADFCMGLYLLLIASVdSQTKGQyynhaidWQTGSGC 439
Cdd:cd15320    7 FLSVLI----LSTLLGNTLVCAAVIRFRHlRSKVTNFFVISLAVSDLLVAVLVMPWKAV-AEIAGF-------WPFGSFC 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 STAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPL---------VGVSNYMK 510
Cdd:cd15320   75 NIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISFIPVqlnwhkakpTSFLDLNA 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 511 VSICFPMD-VETTLSQVY-ILTILILNVVAFFIICACYIKIY--------------------------------FAVRNP 556
Cdd:cd15320  155 SLRDLTMDnCDSSLNRTYaISSSLISFYIPVAIMIVTYTRIYriaqkqirrisaleraavhakncqnstgnrgsGDCQQP 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 557 E---LMATNKDTKIAKKMAILI---------FTDFTCMAPisfFAISAAFKVPLITVTNSKVlLVLFYPINSCANPFLYA 624
Cdd:cd15320  235 EssfKMSFKRETKVLKTLSVIMgvfvccwlpFFILNCMVP---FCKPTSTEPFCISSTTFDV-FVWFGWANSSLNPIIYA 310
                        330
                 ....*....|
gi 106067657 625 iFTKTFQRDF 634
Cdd:cd15320  311 -FNADFRKAF 319
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
365-634 5.90e-06

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 48.45  E-value: 5.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 365 LIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADfcmglyllliASVDSQTKGQYYNHAI-DWQTGSG-CSTA 442
Cdd:cd15090    6 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD----------ALATSTLPFQSVNYLMgTWPFGNIlCKIV 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 443 GFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSN-----YMKVSICFPM 517
Cdd:cd15090   76 ISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTkyrqgSIDCTLTFSH 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 518 DVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDT-----KIAKKMAILIFTDFTCMAPISFFAISA 592
Cdd:cd15090  156 PSWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKdrnlrRITRMVLVVVAVFIVCWTPIHIYVIIK 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 106067657 593 AfkvpLITVTNSKVLLVLFY------PINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15090  236 A----LVTIPETTFQTVSWHfcialgYTNSCLNPVLYAFLDENFKRCF 279
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
362-584 6.32e-06

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 48.22  E-value: 6.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 362 LRVLIWLINILAIMGNMTVLFVLLTS-RYKLTVPRFLMCNLSFADfcmglylLLIASVDSQTKgqyYNHAIDWQTGSG-- 438
Cdd:cd15219    2 LAVLLVVVLVVSLLSNLLVLLCFLYSaELRKQVPGIFLLNLSFCN-------LLLTVLNMPFT---LLGVVRNRQPFGdg 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 439 -CSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWL----FSSLIAMLPLVGVSN-YMKVS 512
Cdd:cd15219   72 fCQAVGFLETFLTSNAMLSMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLhsltFSLVALFLSWLGYSSlYASCT 151
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 106067657 513 ICFPMDVETTLSQVYILTILILNVVAFFII-CACYIKiYFAVRnpelmatnKDTKIAKKMAILIFTDFTCMAP 584
Cdd:cd15219  152 LHLPREEERRRFAVFTAFFHAFTFLLSLLVlCVTYLK-VLKVR--------RRQRATKKISIFIGTFVLCFAP 215
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
364-634 7.41e-06

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 47.92  E-value: 7.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFcmgLYLLLIASVDSQTKGQYYnhaidWQTGSG-CSTA 442
Cdd:cd15215    4 VLIVIFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADL---LQTVLVMPWVIATSVPLF-----WPLDSHlCTAL 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 443 GFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVG--------VSNYMKVsic 514
Cdd:cd15215   76 VVLMHLFAFAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQSTPPLYGwgqaafdeRNALCSV--- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 515 fpmdVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNpelmatNKDTKIAKKMAILIFTDFTCMAPISFFAISAAF 594
Cdd:cd15215  153 ----IWGSSYSYTILSVVSSFVLPVIIMLACYSMVFRAARR------CYHCKAAKVIFIIIFSYVLSMGPYSFLSVLAVW 222
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 106067657 595 KVPLITVTNSKVLLVLFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15215  223 VDTQVPQWVISIILWLFF-LQCCIHPYIYGYMHKSIKKEF 261
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
364-634 7.47e-06

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 47.94  E-value: 7.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLyLLLIASVDSQTKGQYYNHAIdWqtgsgCSTAG 443
Cdd:cd15324    5 LVVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVAT-LVIPFSLANEVMGYWYFGST-W-----CAFYL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 444 FFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNymkvsicfpmDVETTL 523
Cdd:cd15324   78 ALDVLFCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLLMTKH----------DEWECL 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 524 SQVYILTILILNVVAFFIICACYIKIYFAVRNpelMATNKDTKIAKKMAILIFTDFTCMAPisFFAISAAFKVPLITVTN 603
Cdd:cd15324  148 LNDETWYILSSCTVSFFAPGLIMILVYCKIYR---VAKMREKRFTFVLAVVMGVFVLCWFP--FFFTYSLHAVCRKRCGI 222
                        250       260       270
                 ....*....|....*....|....*....|....
gi 106067657 604 SKVLLVLFYPI---NSCANPFLYAIFTKTFQRDF 634
Cdd:cd15324  223 PDALFNLFFWIgycNSSVNPIIYTIFNRDFRKAF 256
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
361-634 8.13e-06

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 48.04  E-value: 8.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYllliaSVDSQTKGQYYNHaidWQTGS-GC 439
Cdd:cd17790    2 LIVITTGILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAF-----SMNLYTTYILMGH---WALGTvAC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 STAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAIlIMLGGWLFSSLIAMLPLVGVSNYmkvsICFPMDV 519
Cdd:cd17790   74 DLWLALDYVASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRAA-IMIGLAWLISFVLWAPAILFWQY----LVGERTV 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 520 ETTLSQVYILTILILN----VVAFF----IICACYIKIYfavrnpelMATNKDTKIAKKMAILIFTDFTCMAPISFFAIS 591
Cdd:cd17790  149 LAGQCYIQFLSQPIITfgtaIAAFYlpvtIMIILYWRIY--------RETIKEKKAARTLSAILLAFILTWTPYNIMVLV 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 106067657 592 AAFKVPLITVTNSKVLLVLFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd17790  221 STFCKDCVPKTLWELGYWLCY-VNSTVNPMCYALCNKSFRDTF 262
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
364-631 8.32e-06

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 47.84  E-value: 8.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLlTSRYKLTVPRFLMCNLSFADFCMGLYL-LLIASVDSQTKGQYynhaiDWQTGSGCSTA 442
Cdd:cd15115    5 VVLSLTFLLGVPGNGLVIWVA-GLKMKRTVNTIWFLNLAVADLLCCLSLpFSIAHLLLNGHWPY-----GRFLCKLLPSI 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 443 GFFTVFASelsVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAmLPLvgvsnyMKVSICFPMDVETT 522
Cdd:cd15115   79 IVLNMFAS---VFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLC-LPV------FIYRTTVTDGNHTR 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 523 LSQVYILTILILNVVAFF-----IICACYIKIYFAVRNPELmaTNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVP 597
Cdd:cd15115  149 CGYDFLVAITITRAVFGFllpllIIAACYSFIAFRMQRGRF--AKSQSKTFRVIIAVVVAFFVCWAPYHIIGILSLYGDP 226
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 106067657 598 LITVTNSKV--LLVLFYPINSCANPFLYAIFTKTFQ 631
Cdd:cd15115  227 PLSKVLMSWdhLSIALAYANSCLNPVLYVFMGKDFK 262
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
368-632 9.23e-06

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 47.95  E-value: 9.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVP--RFLMCnLSFADFCMGLYLLLIAsVDSqtkgqyynhAID--WQTGSG-CSTA 442
Cdd:cd15925    9 LVCAIGLLGNLAVMYLLRNCARRAPPPidVFVFN-LALADFGFALTLPFWA-VES---------ALDfhWPFGGAmCKMV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 443 GFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLfSSLIAMLP---LVGVSNYMKVSICFPMDV 519
Cdd:cd15925   78 LTATVLNVYASVFLLTAMSVTRYWVVASAAGPGTHLSTFWAKIITLALWA-AALLATVPtaiFATEGEVCGVELCLLKFP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 520 ETTLSQVYILTILILN-VVAFFIICACYIKIYFAVRNPELMATNKD--TKIAKKMAILIFTDFTCMAP---ISFFAISAA 593
Cdd:cd15925  157 SNYWLGAYHLQRVVVAfVVPLGVITTSYLLLLSFLQQHKVNQNNRQrqSVIARSVRLVVASFFLCWFPnhvVTFWGVLVK 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 106067657 594 FKVplitVTNSKVLLVL---FYPI-------NSCANPFLYAIFTKTFQR 632
Cdd:cd15925  237 FRA----VPWNSTFYFIhtyVFPVttclahsNSCLNPVLYCLMRREFRQ 281
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
360-624 1.12e-05

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 47.77  E-value: 1.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 360 DFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLM-CNLSFADFCMGLYLLLIASvdsqtkgqYYNHAIDWQTG-S 437
Cdd:cd15376    1 DFLWPILGVEFLVAVLGNGLALWLFVTRERRPWHTGVVFsFNLAVSDLLYALSLPLLAA--------YYYPPKNWRFGeA 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 438 GCSTAGFftVFASEL--SVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMlPLVGVSNYMKV---- 511
Cdd:cd15376   73 ACKLERF--LFTCNLygSIFFITCISLNRYLGIVHPFFTRSHVRPKHAKLVSLAVWLLVAALSA-PVLSFSHLEVErhnk 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 512 SICFPMDVETTLsQVYILTILILNVVA----FFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILI------FTDFTC 581
Cdd:cd15376  150 TECLGTAVDSRL-PTYLPYSLFLAVVGcglpFLLTLASYLAIVWAVLRSPGITTLEKRKVAALVAVVValyavsFVPYHI 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 106067657 582 MAPISFFAISAAFKV-----PLITVTNSKVLLvlfyPINSCANPFLYA 624
Cdd:cd15376  229 LRNLNLYRRLQWLKAaaslrIYFAYQVTKGLV----TLNMCIHPLLYM 272
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
361-634 1.22e-05

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 47.48  E-value: 1.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKgqyynhaiDWQTGSG-C 439
Cdd:cd15296    2 ILAVLMALLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGFCIPLYIPYVLTG--------RWKFGRGlC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 STAGFFTVFASELSVYTLTVITLERWHTITYAI-HLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSI----- 513
Cdd:cd15296   74 KLWLVVDYLLCTASVFNIVLISYDRFLSVTRAVsYRAQKGMTRQAVLKMVLVWVLAFLLYGPAIISWEYIAGGSIipege 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 514 CFpmdVETTLSQVYILTILILNVVAFFIICACY-IKIYFAVRNPELMATnKDTKIAKKMAILIFTDFTCMAPISFFA-IS 591
Cdd:cd15296  154 CY---AEFFYNWYFLMTASTLEFFTPFISVTYFnLSIYLNIQKRRFRLS-RDKKVAKSLAIIVCVFGLCWAPYTLLMiIR 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 106067657 592 AAFKVPLITVTNSKVLLVLFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15296  230 AACHGHCVPDYWYETSFWLLW-VNSAINPVLYPLCHMSFRRAF 271
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
368-634 1.29e-05

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 47.73  E-value: 1.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMglyLLLIASVDSQTKGQYYnhaiDWQTG-SGCSTAGFFT 446
Cdd:cd14979    9 AIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLI---LLVGLPVELYNFWWQY----PWAFGdGGCKLYYFLF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 447 VFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIA--MLPLVGVSNYMKV--------SICFP 516
Cdd:cd14979   82 EACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAipILFLMGIQYLNGPlpgpvpdsAVCTL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 517 MDVETTLSQVYILTILILNVVAFFIICACYIKIYFAV---RNPELMATNKDTK-------------IAKKMAILIFTDFT 580
Cdd:cd14979  162 VVDRSTFKYVFQVSTFIFFVLPMFVISILYFRIGVKLrsmRNIKKGTRAQGTRnvelslsqqarrqVVKMLGAVVIAFFV 241
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 106067657 581 CMAPisFFAISAAFKVPLITVTNSKVLLVLFYPI-------NSCANPFLYAIFTKTFQRDF 634
Cdd:cd14979  242 CWLP--FHAQRLMFSYASKEDTFLFDFYQYLYPIsgilfylSSAINPILYNLMSSRFRVAF 300
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
364-634 1.33e-05

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 47.59  E-value: 1.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSqtkgqYYNHAidWQTGSG-CSTA 442
Cdd:cd15305    5 LLILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAI-----LYDYA--WPLPRYlCPIW 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 443 GFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAM-LPLVGVSNYMKV---SICFPMD 518
Cdd:cd15305   78 ISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIGISMpIPVIGLQDDEKVfvnGTCVLND 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 519 VettlsqvyiLTILILNVVAFFI----ICACYIKIYFAVRNPElmATNKDTKIAKKMAILIFTDFTCMAPisfFAISAAF 594
Cdd:cd15305  158 E---------NFVLIGSFVAFFIpliiMVITYCLTIQVLQRQQ--AINNERRASKVLGIVFFLFLIMWCP---FFITNIL 223
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 106067657 595 KVPLITVTNSKVL------LVLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15305  224 SVLCKEACDQKLMeellnvFVWVGYVSSGINPLVYTLFNKTYRRAF 269
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
362-634 1.62e-05

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 47.19  E-value: 1.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 362 LRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMgLYLLLIASVDSQTKGQyynhaidWQTGS-GCS 440
Cdd:cd15325    3 LGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLL-TSTVLPFSAIFEILGY-------WAFGRvFCN 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 441 TAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNymkvsicfPMDVE 520
Cdd:cd15325   75 IWAAVDVLCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIGPLFGWKE--------PAPED 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 521 TTLSQV------YILTILILNVVAFFIICACYIKIYFAVrnpelMATNKDTKIAKKMAILIFTDFTCMAPisFF---AIS 591
Cdd:cd15325  147 ETICQIteepgyALFSALGSFYLPLAIILVMYCRVYVVA-----LKFSREKKAAKTLGIVVGCFVLCWLP--FFlvmPIG 219
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 106067657 592 AAFKVPLITVTNSKVLLVLFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15325  220 SIFPAYKPSDTVFKITFWLGY-FNSCINPIIYPCSSQEFKKAF 261
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
364-508 1.74e-05

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 46.86  E-value: 1.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKgqyynhaiDWQTGS-GCSTA 442
Cdd:cd15214    4 IAIIIIAILICLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRR--------EWIFGVvWCNFS 75
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 106067657 443 GFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNY 508
Cdd:cd15214   76 ALLYLLISSASMLTLGAIAIDRYYAVLYPMVYPMKITGNRAVLALVYIWLHSLIGCLPPLFGWSSL 141
7tmA_S1PR2_Edg5 cd15347
sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial ...
360-634 1.97e-05

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320469 [Multi-domain]  Cd Length: 266  Bit Score: 46.73  E-value: 1.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 360 DFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLylLLIASVDSQTKGQYYNHAIDWQTGSGc 439
Cdd:cd15347    1 QVASIFIVILCCIIVLENLLVLIAVARNKKFHSAMFFFIGNLAFSDLLAGV--AFIANILLSGSVTFRLTPVQWFIREG- 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 stAGFFTVFASelsVYTLTVITLERWHTITyAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVG---VSNYMKVSICFP 516
Cdd:cd15347   78 --TAFITLSAS---VFSLLAIAIERHVAIT-KVKLYGSDKNCRMVLLIGACWVISIVLGGLPILGwncIGNLEDCSTVLP 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 517 MDvettlSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDT-KIAKKMAILIFTDFTCMAP-ISFFAISAAF 594
Cdd:cd15347  152 LY-----SKHYILFVVTIFSIILLSIVILYVRIYCIVRSSHAEMAAPQTlALLKTVTIVLGVFIVCWLPaFIILLLDTSC 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 106067657 595 KVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15347  227 KVKSCPILYKADYFFSVATLNSALNPVIYTLRSKDMRKEF 266
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
368-584 2.07e-05

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 47.01  E-value: 2.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADfcmgLYLLLIASvdsqTKGQYYNHAIDWQTGS-GCSTAGFFT 446
Cdd:cd15161    9 LVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVAD----LSYVLILP----MRLVYHLSGNHWPFGEvPCRLAGFLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 447 VFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSlIAMLPLVGVSNYMK---VSICFPMDVETTl 523
Cdd:cd15161   81 YLNMYASLYFLACISVDRFLAIVHPVKSMKIRKPLYAHVVCGFLWVIVT-VAMAPLLVSPQTVEvnnTTVCLQLYREKA- 158
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 106067657 524 SQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKiAKKMAILIFTDF-TCMAP 584
Cdd:cd15161  159 SRGALVSLAVAFTIPFVTTVTCYLLIIRSLRTGKREEKPLKDK-AIKMIILVLTIFlICFVP 219
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
368-634 2.09e-05

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 46.87  E-value: 2.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADfcmglyLLLIASVDSQTKGQYYNhaiDWQTGSG-CSTAGFFT 446
Cdd:cd15091    9 VVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALAD------ALVTTTMPFQSTVYLMN---SWPFGDVlCKIVISID 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 447 VFASELSVYTLTVITLERWHTITYAIH-LDQKLRLRhAILIMLGGWLFSSLIAMLPLV-------GVSNYMKVSICFPMD 518
Cdd:cd15091   80 YYNMFTSIFTLTMMSVDRYIAVCHPVKaLDFRTPLK-AKIINICIWLLSSSVGISAIVlggtkvrEDVDSTECSLQFPDD 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 519 VETTLSQVYILTILILN-VVAFFIICACYIKIYFAVRNPELMATNKDT-----KIAKKMAILIFTDFTCMAPISFFAISA 592
Cdd:cd15091  159 DYSWWDTFMKICVFIFAfVIPVLIIIVCYTLMILRLKSVRLLSGSREKdrnlrRITRLVLVVVAVFVVCWTPIHIFILVE 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 106067657 593 AfkvpLITVTNSKVLLVLFY------PINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15091  239 A----LGSVSHSTAAVSSYYfcialgYTNSSLNPILYAFLDENFKRCF 282
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
369-634 2.14e-05

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 47.04  E-value: 2.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 369 INILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASvdsQTKGQYYnhaidWQTGSG-CSTAGFFTV 447
Cdd:cd15192   10 IFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCFLITLPLWAA---YTAMEYH-----WPFGNFlCKIASALVS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 448 FASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLiAMLPLVGVSNYMKVS-----IC---FPMDV 519
Cdd:cd15192   82 FNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGV-ASLPAIIHRDVFFIEntnitVCafhYPSQN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 520 ETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNK--DTKIAKKMAILIFTDFTCMAPISFFAISAAFkVP 597
Cdd:cd15192  161 STLLVGLGLMKNLLGFLIPFLIILTCYTLIGKALKKAYEIQRNKprNDEIFKMIMAVVLFFFFCWIPHQIFTFLDVL-IQ 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 106067657 598 LITVTNSKVLLVLFYPI---------NSCANPFLYAIFTKTFQRDF 634
Cdd:cd15192  240 LKVIQDCHIADIVDTAMpfticiayfNSCLNPILYGFVGKNFRKKF 285
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
377-605 2.25e-05

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 46.75  E-value: 2.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 377 NMTVLFVLLTSRYKLTVPRFLMCNLSFADFCM---GLYLLLIASVDSqtkgqYYNHAIdwqtgSGCSTAGFFTVFASELS 453
Cdd:cd15080   18 NFLTLYVTVQHKKLRTPLNYILLNLAVADLFMvfgGFTTTMYTSMHG-----YFVFGP-----TGCNLEGFFATLGGEIA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 454 VYTLTVITLERWHTITYAIHlDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNY----MKVSiCFPmDVETTLSQVYIL 529
Cdd:cd15080   88 LWSLVVLAIERYVVVCKPMS-NFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYipegMQCS-CGI-DYYTLKPEVNNE 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 530 TILI-LNVVAFFI----ICACYIKIYFAVRNP-----ELMATNKDTKIAKKMAILIFTDF-------------------T 580
Cdd:cd15080  165 SFVIyMFVVHFTIplivIFFCYGRLVCTVKEAaaqqqESATTQKAEKEVTRMVIIMVIAFlicwvpyasvafyifthqgS 244
                        250       260       270
                 ....*....|....*....|....*....|
gi 106067657 581 CMAPI-----SFFAISAAFKVPLITVTNSK 605
Cdd:cd15080  245 DFGPIfmtipAFFAKSSAVYNPVIYILMNK 274
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
348-630 2.55e-05

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 47.08  E-value: 2.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 348 DAFNPCEDIMGYD----FLRVLIWLINILAIMGNMTVLFVLltSRYKL-TVPRFLMCNLSFADfcmglyLLLIASVDSQT 422
Cdd:PHA03087  25 EDYADCDLNIGYDtnstILIVVYSTIFFFGLVGNIIVIYVL--TKTKIkTPMDIYLLNLAVSD------LLFVMTLPFQI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 423 kgqYYNHAIDWQTGS-GCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSsLIAMLP 501
Cdd:PHA03087  97 ---YYYILFQWSFGEfACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIIS-IIETTP 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 502 LVGVSNYMKV---SICFPMDVETTLSQVYILTILIlNVVAFFI----ICACYIKIYFAVRNpelMATNKDTKIAKKMAIL 574
Cdd:PHA03087 173 ILFVYTTKKDhetLICCMFYNNKTMNWKLFINFEI-NIIGMLIpltiLLYCYSKILITLKG---INKSKKNKKAIKLVLI 248
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 106067657 575 IFTDFT-CMAP--ISFFAISA---AFKVPLITVtnSKVLLVLFYP-----INSCANPFLYAIFTKTF 630
Cdd:PHA03087 249 IVILFViFWLPfnVSVFVYSLhilHFKSGCKAV--KYIQYALHVTeiislSHCCINPLIYAFVSEFF 313
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
371-634 2.63e-05

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 46.58  E-value: 2.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 371 ILAIMGNMTVLFVLltSRYK-LTVP-RFLMCNLSFADFCMGLYLL---LIASVDSQtkgqyynhaidWQTGSG-CSTAGF 444
Cdd:cd15312   12 LLTVFGNLMVIISI--SHFKqLHSPtNFLILSLAITDFLLGFLVMpysMVRSVESC-----------WYFGDLfCKIHSS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 445 FTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAM------LPLVGVSNYMKVSICfpmd 518
Cdd:cd15312   79 LDMMLSTTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFAFgvvfseVNLEGIEDYVALVSC---- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 519 vetTLSQVYILTIL---ILNVVAFFIIC----ACYIKIYFAVR----------------NPELMATNKDTKIAKKMAILI 575
Cdd:cd15312  155 ---TGSCVLIFNKLwgvIASLIAFFIPGtvmiGIYIKIFFVARkhakvinnrpsvtkgdSKNKLSKKKERKAAKTLSIVM 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 106067657 576 FTDFTCMAPISFFAISAafkvPLITVTNSKVL---LVLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15312  232 GVFLLCWLPFFVATLID----PFLNFSTPVDLfdaLVWLGYFNSTCNPLIYGFFYPWFQKAF 289
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
362-624 3.37e-05

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 46.32  E-value: 3.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 362 LRVLIWLINILAIMGNMTVLFVLLtsrYKLTVPRFLMC---NLSFADFCMGL-YLLLIASVDSQTkgqYYNHAIDWQTGS 437
Cdd:cd15349    3 LTVLFICISVLIILENLLVLLAIL---RRVRLRRWVYIclaNIALSDLLTGTsYLVNICLSGERT---FRLTPALWFLRE 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 438 GCstagFFTVFASelSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICfpm 517
Cdd:cd15349   77 GL----LFTALAA--STFSLLVTAVERYATMVRPVAENTATKTYRVYGMIVLCWILAFLIGFLPLLGWNCLCDFRSC--- 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 518 dveTTLSQVYILTILILNVVAFFIICACYIKIYFAV---------RNPELMATNKDTKIAKKMAILIFTDFTCMAPISFF 588
Cdd:cd15349  148 ---SSLLPLYSKSYILFCLVIFFIILLTIIGLYFAIyclvrasgqRVISARSRRRSLRLLKTVLMILGAFMVCWGPLFIL 224
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 106067657 589 AISAAFKVPLITVTNSKVLLVLFYPI-NSCANPFLYA 624
Cdd:cd15349  225 LLVDFFCSSRSCKPLFGMEWVLALAVlNSAINPLIYS 261
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
373-634 3.44e-05

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 46.13  E-value: 3.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 373 AIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVdsqtkgqyYNHAIDWQTGS-GCSTAGFFTVFASE 451
Cdd:cd15330   14 AIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAAL--------YQVLNKWTLGQvTCDLFIALDVLCCT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 452 LSVYTLTVITLERWHTITYAI-HLDQKLRLRHAILIMLGgWLFSSLIAMLPLVGVS--------NYMKVSICFPMDVETT 522
Cdd:cd15330   86 SSILHLCAIALDRYWAITDPIdYVNKRTPRRAAVLISLT-WLIGFSISIPPMLGWRtpedrsdpDACTISKDPGYTIYST 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 523 LSQVYILTILILnvvaffiicACYIKIYfavrnpelMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVT 602
Cdd:cd15330  165 FGAFYIPLILML---------VLYGRIF--------KAAARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESTCHMP 227
                        250       260       270
                 ....*....|....*....|....*....|....
gi 106067657 603 N--SKVLLVLFYPiNSCANPFLYAIFTKTFQRDF 634
Cdd:cd15330  228 EllGAIINWLGYS-NSLLNPIIYAYFNKDFQSAF 260
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
361-502 3.65e-05

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 46.29  E-value: 3.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKgqyynhaiDWQTGS-GC 439
Cdd:cd15058    2 GLLLLLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTG--------KWQLGNfWC 73
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 106067657 440 STAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPL 502
Cdd:cd15058   74 ELWTSVDVLCVTASIETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVSFVPI 136
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
361-634 3.87e-05

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 46.19  E-value: 3.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIwlinILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHA--IDWQT-GS 437
Cdd:cd15065    5 FLSLII----VLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETfcNIWISfDV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 438 GCSTAgfftvfaselSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPL-----------VGVS 506
Cdd:cd15065   81 MCSTA----------SILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFLPIhlgwhrlsqdeIKGL 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 507 NYMKVSI--CFpMDVETTLSQVYiltililNVVAFFIIC----ACYIKIYFAVR--------------------NPELMA 560
Cdd:cd15065  151 NHASNPKpsCA-LDLNPTYAVVS-------SLISFYIPClvmlLIYSRLYLYARkhvvniksqklpsesgskfqVPSLSS 222
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 106067657 561 TN-----KDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15065  223 KHnnqgvSDHKAAVTLGIIMGVFLICWLPFFIINIIAAFCKTCIPPKCFKILTWLGY-FNSCLNPIIYSIFNSEFRRAF 300
7tmA_LPAR cd15101
lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane ...
371-634 4.00e-05

lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341325 [Multi-domain]  Cd Length: 274  Bit Score: 45.97  E-value: 4.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 371 ILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGL-YLLLIASVDSQTKGQYYNhaiDWQTGSGCSTAGFFTvfa 449
Cdd:cd15101   12 IFIMLANLLVIAAIYKNRRFHFPIYYLLANLAAADFFAGLaYFFLMFNTGPNTRRLTVS---TWFLRQGLLDTSLTA--- 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 450 selSVYTLTVITLERwHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMdvETTLSQVYIL 529
Cdd:cd15101   86 ---SVANLLAIAVER-HISVMRMQLHSRLSNRRVVVLIVLVWTMAIVMGAIPSVGWNCLCAIDACSNM--APLYSRSYLV 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 530 TILILNVVAFFIICACYIKIYFAVRNPEL-MAT-------NKDT--KIAKKMAILIFTDFTCMAP---ISFFAISAAFKV 596
Cdd:cd15101  160 FWAISNLVTFLVMVVVYARIFVYVRRRTNrMSPhtsgsirNRDTmmSLLKTVVIVLGAFVVCWTPglvVLLLDGLCCRQC 239
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 106067657 597 PLITVTNSKVLLVLFypiNSCANPFLYAIFTKTFQRDF 634
Cdd:cd15101  240 NVLAVEKFFLLLAEF---NSAVNPIIYSYRDKEMSGTF 274
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
368-634 4.65e-05

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 45.97  E-value: 4.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTkgqYYNHAIDWQtgsgCSTAGFFTV 447
Cdd:cd15385    9 VIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFFQVLPQLCWDIT---YRFYGPDFL----CRIVKHLQV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 448 FASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILImLGGWLFSSLIA-----MLPLVGVSNYMKVSICFPMDVETT 522
Cdd:cd15385   82 LGMFASTYMLVMMTADRYIAICHPLKTLQQPTKRSYLMI-GSAWALSFILStpqyfIFSLSEIENGSGVYDCWANFIVPW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 523 LSQVYILTILI-LNVVAFFIICACYIKIYFAV-RNPELMATNKDTKIAK-----------------------KMAILIFT 577
Cdd:cd15385  161 GIKAYITWITIsIFVVPVIILLTCYGFICYNIwRNIKCKTRRGLSDNALknillavcvssvktisrakirtvKMTFVIVL 240
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 106067657 578 DF-TCMAPisFFAISA----AFKVPLITVTNSKVLL-VLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15385  241 AYiVCWAP--FFTIQMwsvwDQNFPWDESENTAVTItALLASLNSCCNPWIYMFFSGHLLQDF 301
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
368-634 5.29e-05

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 45.49  E-value: 5.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVdsqtkgqyYNHAIDWQTGS-GCSTAGFFT 446
Cdd:cd15000    8 PVVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLV--------HDFFQNYVLGSvGCKLEGFLE 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 447 VFASELSVYTLTVITLERwhtiTYAIHLDQKLRL--RHAILIMLGGWLFSSLIAmLPLVGVSNYMK-------VSICFPm 517
Cdd:cd15000   80 GSLLLASVLALCAVSYDR----LTAIVLPSEARLtkRGAKIVIVITWIVGLLLA-LPLAIYRSYRErqwknflETYCAE- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 518 dvETTLSQVY---ILTILILnvVAFFIICACYIKIYF--------AVRNPELMATNKDTKIAKKMAILIFTDFTCMAPIS 586
Cdd:cd15000  154 --NTQVLPIYwhvIITVLVW--LPLGIMLICYSAIFWkldkyerrVLRREHPSVVRYKKKAAKTLFIVLITFVVCRIPFT 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 106067657 587 FFAISAAFKVPLITVTNS--KVLLVLFYP------INSCANPFLYAIFTKTFQRDF 634
Cdd:cd15000  230 ALIFYRYKLVPNDNTQNSvsGSFHILWFAskylmfLNAAVNPLIYGFTNENFRKAF 285
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
371-634 5.62e-05

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 45.82  E-value: 5.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 371 ILAIMGNMTVLFVLLTSRYKLTVP-RFLMCNLSFADFcmgLYLLLIASVDSqtkgqYYNHAIDWQTGS-GCSTAGFFTVF 448
Cdd:cd15383   12 VLSACSNLAVLWSATRNRRRKLSHvRILILHLAAADL---LVTFVVMPLDA-----AWNVTVQWYAGDlACRLLMFLKLF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 449 ASELSVYTLTVITLERWHTITYAIH-LDQKLRLRhailIMLG-GWLFSSLIAmLP------LVGVSNYMKVSIC-----F 515
Cdd:cd15383   84 AMYSSAFVTVVISLDRHAAILNPLAiGSARRRNR----IMLCaAWGLSALLA-LPqlflfhTVTATPPVNFTQCathgsF 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 516 PMDVETTLsqVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTK----------IAK------KMAILIFTDF 579
Cdd:cd15383  159 PAHWQETL--YNMFTFFCLFLLPLLIMIFCYTRILLEISRRMKEKKDSAKNevalrsssdnIPKarmrtlKMTIVIVSSF 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 106067657 580 -TCMAPISFFAISAAFKVPLITVTNSKVL---LVLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15383  237 iVCWTPYYLLGLWYWFSPEMLEQTVPESLshiLFLFGLLNACLDPLIYGLFTISFRRGL 295
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
364-634 6.03e-05

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 45.57  E-value: 6.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKLTVP--RFLMCNLSFADFCMGLYLLLIAsVDSqtkgqYYNHAidWQTGSG-CS 440
Cdd:cd14976    5 VVYMVVFTVGLLGNLLVLYLLKSNKKLRQQSesNKFVFNLALTDLIFVLTLPFWA-VEY-----ALDFV--WPFGTAmCK 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 441 TAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLfSSLIAMLP-------LVGVSNYMKVSI 513
Cdd:cd14976   77 VVRYVTKLNMYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWA-AAALAAIPeaifstdTWSSVNHTLCLL 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 514 CFPMDVETTLSQ----VYILTILILN-VVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFF 588
Cdd:cd14976  156 RFPKNSSVTRWYnwlgMYQLQKVVLGfFLPLGIITLSYLLLLRFLQRKRGGSKRRKSRVTKSVFIVVLSFFICWLPNQAL 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 106067657 589 AISAAFKVPLITVTNSKVLL--VLFYPI-------NSCANPFLYAIFTKTFQRDF 634
Cdd:cd14976  236 SLWSALIKFDDVPFSDAFFAfqTYAFPVaiclahsNSCLNPVLYCLVRREFRDAL 290
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
365-632 6.08e-05

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 45.58  E-value: 6.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 365 LIWLINILAIMGNMTVLFVLLTSRYKlTVPRFLMCNLSFADFcmgLYLLLIASVDSQtkgqyYNHAIDWQTGSG-CSTAG 443
Cdd:cd15339    6 FIGILCSTGLVGNILVLFTIIRSRKK-TVPDIYVCNLAVADL---VHIIVMPFLIHQ-----WARGGEWVFGSPlCTIIT 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 444 FFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLfSSLIAMLPlvgVSNYMKVsICFPMDVE--- 520
Cdd:cd15339   77 SLDTCNQFACSAIMTAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVWA-ASFILVLP---VWVYAKV-IKFRDGLEsca 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 521 ---TTLSQVYILTiLILNVVAFF----IICACYIKIYFAV-----RNPELMATNKDT------KIAKKMAILIFTDFTCM 582
Cdd:cd15339  152 fnlTSPDDVLWYT-LYQTITTFFfplpLILICYILILCYTwemyrKNKKAGRYNTSIprqrvmRLTKMVLVLVGVFLVSA 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 106067657 583 APISFFAI-SAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQR 632
Cdd:cd15339  231 APYHVIQLvNLSVSQPTLAFYVSYYLSICLSYASSSINPFLYILLSGNFRK 281
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
360-632 6.86e-05

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 45.20  E-value: 6.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 360 DFLRVLIWLINILAIMGNMTVLfvLLTSRYK-LTVP-RFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAidwqtgs 437
Cdd:cd15078    1 ELLALLIATIGFLGVCNNLLVL--ILYYKFKrLRTPtNLLLVNISLSDLLVSLLGVTFTFMSCVRGRWVFDVA------- 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 438 GCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILImlggWLFSSLIAMLPLVGVSNYM----KVSI 513
Cdd:cd15078   72 GCVWDGFSNSLFGIVSIMTLTVLAYERYIRVVHAKVVNFSWSWRAITYI----WLYSLAWTGAPLLGWNRYTlevhGLGC 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 514 CFPMDVETTLSQVYILTILI-LNVVAFFIICACYIKIYFAVR------NPELMATNKDTKIAKKMA----ILIFTDFTCM 582
Cdd:cd15078  148 SFDWKSKDPNDTSFVLLFFLgCLVVPLGIMAYCYGHILYEIRmlrsveDLQTFQVIKILKYEKKVAkmclLMISTFLICW 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 106067657 583 AP---ISFFAISAAFKVPLITVTnskVLLVLFYPINSCANPFLYAIFTKTFQR 632
Cdd:cd15078  228 MPyavVSLLVTSGYSKLVTPTIA---IIPSLFAKSSTAYNPVIYIFMIRKFRQ 277
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
361-634 6.95e-05

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 45.31  E-value: 6.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIdwqtgsgCS 440
Cdd:cd15314    2 LLYIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSMVRSVETCWYFGDLF-------CK 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 441 TAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIA----MLPLVGVSNYMKVSICFP 516
Cdd:cd15314   75 IHSSFDITLCTASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALVGfgiiFLELNIKGIYYNHVACEG 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 517 MDVETTLSQVYILTILILNVVAFFIICACYIKIYF-----------AVRNPELMATNKDTKIAKKMAILIFTDFTCMAPi 585
Cdd:cd15314  155 GCLVFFSKVSSVVGSVFSFYIPAVIMLCIYLKIFLvaqrqarsiqsARTKSGASSSKMERKATKTLAIVMGVFLLCWTP- 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 106067657 586 SFFAISAafkVPLITVTNSKVL---LVLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15314  234 FFLCNII---DPFINYSIPPVLievLNWLGYSNSTLNPFIYAFFYSWFRKAF 282
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
361-634 7.26e-05

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 45.16  E-value: 7.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFC--MGLYLLLIASVDSQtkgqyynhaidWQTGSG 438
Cdd:cd15094    2 ISAVLYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECflIGLPFLIVTMILKY-----------WPFGAA 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 439 CSTAgFFTVFA--SELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIaMLPLVGVSNYMKVS---- 512
Cdd:cd15094   71 MCKI-YMVLTSinQFTSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLV-MLPIILYASTVPDSgrys 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 513 --ICFPMDVETTLSQVYILTILILNvvafFIICACYIKIYFAVRNPELMATNKDTKIAKK---------MAILIFTDFT- 580
Cdd:cd15094  149 ctIVWPDSSAVNGQKAFTLYTFLLG----FAIPLLLISVFYTLVILRLRTVGPKNKSKEKrrshrkvtrLVLTVISVYIi 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 106067657 581 CMAPISFFAISAAFK-----VPLITVTNSKVLLVLFYPiNSCANPFLYAIFTKTFQRDF 634
Cdd:cd15094  225 CWLPYWAFQVHLIFLppgtdMPKWEILMFLLLTVLSYA-NSMVNPLLYAFLSENFRKSF 282
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
361-634 7.37e-05

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 45.28  E-value: 7.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMcNLSFADFCMGLYLLLIAsvdsqtkgqyYNHAIDWQTG---- 436
Cdd:PHA02834  30 FVIVFYILLFIFGLIGNVLVIAVLIVKRFMFVVDVYLF-NIAMSDLMLVFSFPFII----------HNDLNEWIFGefmc 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 437 ---SGCSTAGFFTvfaselSVYTLTVITLERWHTITYAIHLDQKlRLRHAILIMLGGWLFSSLIAM--LPLVGVSNYMKV 511
Cdd:PHA02834  99 klvLGVYFVGFFS------NMFFVTLISIDRYILVVNATKIKNK-SISLSVLLSVAAWVCSVILSMpaMVLYYVDNTDNL 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 512 SICFPMDVET--TLSQVYILTILILNVVAFFIICA-CYIKIYFAVRNPElmATNKDTKIAKKMAILIFTDFTCMAPISFF 588
Cdd:PHA02834 172 KQCIFNDYHEnfSWSAFFNFEINIFGIVIPLIILIyCYSKILYTLKNCK--NKNKTRSIKIILTVVTFTVVFWVPFNIVL 249
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 106067657 589 AISAAFKVPLITVT--------NSKVLLVLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:PHA02834 250 FINSLQSVGLIDIGcyhfkkivYSIDIAELISFVHCCVNPIIYAFVGKNFKKVF 303
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
368-627 7.88e-05

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 45.19  E-value: 7.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTkgqYYNHAIDWQtgsgCSTAGFFTV 447
Cdd:cd15387    9 LILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVFQVLPQLIWDIT---FRFYGPDFL----CRLVKYLQV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 448 FASELSVYTLTVITLERWHTITYAIhldQKLRLRHAILIMLGGWLFsSLIAMLPLVGVSNYMKVSI----CFPMDVETTL 523
Cdd:cd15387   82 VGMFASTYMLLLMSIDRCLAICQPL---RSLHRRSDRVYVLFSWLL-SLVFSIPQVHIFSLREVGNgvydCWADFIQPWG 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 524 SQVYILTI-LILNVVAFFIICACYIKIYFAVRNPELMATNKDTKI-----------------------AK----KMAILI 575
Cdd:cd15387  158 PKAYITWItLSVYIIPVLILSVCYGLISFKIWQNVKLKTRRETKTplssaasggaalarvssvkliskAKirtvKMTFVI 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 106067657 576 FTDF-TCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFT 627
Cdd:cd15387  238 VLAYiVCWTPFFFVQMWSVWDPNAPKEASPFIIAMLLASLNSCCNPWIYMFFT 290
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
372-634 8.12e-05

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 45.30  E-value: 8.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 372 LAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFcmgLYLLLIASVDSQtkgQYYnhAIDWQTGS-GCSTAGFFTVFAS 450
Cdd:cd15123   13 VGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDL---LLLLTCVPVDAT---RYI--ADTWLFGRiGCKLLSFIQLTSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 451 ELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNY--------MKVSICFPMDVETT 522
Cdd:cd15123   85 GVSVFTLTVLSADRYRAIVKPLELQTSDAVLKTCCKAGCVWIVSMLFAIPEAVFSDLYsfrdpeknTTFEACAPYPVSEK 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 523 LSQ----------VYILTILILNVVaFFIICACYIKIYFAVRNPELMATNKD----TKIAKKMAILIFTDFTCMAPISFF 588
Cdd:cd15123  165 ILQeihsllcflvFYIIPLSIISVY-YFLIARTLYKSTFNMPAEEHSHARKQiesrKRVAKTVLVLVALFAFCWLPNHIL 243
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 106067657 589 AISAAFK---------VPLITVTNSKVLLVlfypINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15123  244 YLYRSFTyhtsvdssaFHLIATIFSRVLAF----SNSCVNPFALYWLSKSFRQHF 294
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
371-631 8.61e-05

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 45.17  E-value: 8.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 371 ILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADfcmgLYLLLIASVDSQTKGQYYnhaiDWQTGSG-CSTAGFFTVFA 449
Cdd:cd15928   12 LVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSD----LLIFLVLPLDLYRLWRYR----PWRFGDLlCRLMYFFSETC 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 450 SELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIA--MLPLVGVSNYMKVSICFPMDVETTLSQVY 527
Cdd:cd15928   84 TYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAgpALVLVGVEHIQGQQTPRGFECTVVNVSSG 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 528 ILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDT-------------KIAKKMAILIFTDFTCMAP------ISFF 588
Cdd:cd15928  164 LLSVMLWVSTSFFFVPMVCLSLLYGLIGRALWDRRQRSrtagasrrdnnhrQTVRMLAVIVLAFVLCWLPfhvgrvIFNH 243
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 106067657 589 AISAAFKVPLITVTNSKVLLVLFYpINSCANPFLYAIFTKTFQ 631
Cdd:cd15928  244 SRASTKHLHYVSQYFNLVSFVLFY-LSAAINPILYNLMSKRYR 285
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
361-634 9.42e-05

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 44.74  E-value: 9.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADfcmgLYLLLI---ASVDSqtkgqyynhAIDWQTGS 437
Cdd:cd15181    2 FIPLAYSLVFLLGVVGNGLVLTILLRRRRSRRTTENYLLHLALAD----LLLLLTfpfSVVES---------IAGWVFGT 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 438 -GCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPL----VGVSNYMKVS 512
Cdd:cd15181   69 fLCKLVGAIHKLNFYCSSLLLACISVDRYLAIVHAIHSYRHRRLRSVHLTCGSIWLVCFLLSLPNLvfleVETSTNANRT 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 513 ICFPMDVETTLSQVYILTILILNVVAFF----IICACYIKIYFAVRNPELMATNKDtkiAKKMAILIFTDF-TCMAPISF 587
Cdd:cd15181  149 SCSFHQYGIHESNWWLTSRFLYHVVGFFlpllIMGYCYATIVVTLCQSSRRLQKQK---AIRVAILVTLVFcLCWLPYNI 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 106067657 588 FAISAAFKVPLITVTNSKVLLVLFYPI---------NSCANPFLYAIFTKTFQRDF 634
Cdd:cd15181  226 VIFLDTLDDLKAVVKNCKLNDLLDAAItvteslgfsHCCLNPILYAFIGVKFRNDL 281
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
371-633 1.01e-04

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 44.81  E-value: 1.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 371 ILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIasvdsqTKGQYYNHAidWQTGSG-CSTAGFFTVFA 449
Cdd:cd15391   12 FLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPF------TFTQIMLGH--WVFPAPmCPIVLYVQLVS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 450 SELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVS----IC---FPMDveTT 522
Cdd:cd15391   84 VTASVLTNTAIGIDRFFAVIFPLRSRHTKSRTKCIIASIWAISFSLSSVQLFAGRTQRYGQYSegrvLCgesWPGP--DT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 523 LSQVYILTILILN-VVAFFIICACYIKIYF----------AVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAIS 591
Cdd:cd15391  162 SRSAYTVFVMLLTyIIPLLILTSTYGYVGFrlwnrtapgnADKGRDDMQIKSKRKVIKMLVFVVLMFGICWLPLHLFNLV 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 106067657 592 AAFKVPLITVTNSKVLLVLFYPI-----NSCANPFLYAIFTKTFQRD 633
Cdd:cd15391  242 QDFSTVFRNMPQHTTRLIYGACHwiamsNSFVNPIIYLFMNDSFRSI 288
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
364-634 1.10e-04

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 44.68  E-value: 1.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADfcmgLYLLLIASVDSQTKgqyYNHAID-WQTGS-GCST 441
Cdd:cd14995    5 FLVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVAD----LMVLVAAGLPNEIE---SLLGPDsWIYGYaGCLL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 442 AGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPL------VGVSNYMKVSIC- 514
Cdd:cd14995   78 ITYLQYLGINASSLSITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCSPWLflldlsIKHYGDDIVVRCg 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 515 FPMDVETTLSqVYILTILILNVVAFFIICACYIKIYFAvrnpeLMATNKdtKIAKKMAILIFTDFTCMAPISFFAISAAF 594
Cdd:cd14995  158 YKVSRHYYLP-IYLADFVLFYVIPLLLAIVLYGLIGRI-----LFSSRK--QVTKMLAVVVVLFALLWMPYRTLVVYNSF 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 106067657 595 KVPliTVTNSKVLLV---LFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd14995  230 ASP--PYLDLWFLLFcrtCIY-LNSAINPILYNLMSQKFRAAF 269
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
366-631 1.26e-04

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 44.40  E-value: 1.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 366 IWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFAD--FCMGLYLLliasvdSQTKGQYYNhaidWQTGSG-CSTA 442
Cdd:cd15380    7 IIAICFFGLLGNLFVLFVFLLPRRRLTIAEIYLANLAASDlvFVLGLPFW------AENIRNQFN----WPFGNFlCRVI 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 443 GFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIA----MLPLVGVSNYMKVSIC---F 515
Cdd:cd15380   77 SGVIKANLFISIFLVVAISQDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGLLSiptfLFRSVKHVPDLNISACillF 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 516 PMDVettlsqVYILTILILNVVAFFIICACYIKIYF----AVRNPELMATN-----KDTKIAKKMAILIFTDFTCMAPIS 586
Cdd:cd15380  157 PHEA------WHFARRVELNIVGFLLPLAAIVFFNFhiiaSLRERTEESRKrcgglKDTKATRLILTLVLMFLVCWTPYH 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 106067657 587 FFA-ISAAFKVPLIT-------VTNSKVLLVLFYPINSCANPFLYAIFTKTFQ 631
Cdd:cd15380  231 FFAfLDFLFQVEVIQgcfweefIDLGLQLANFFAFANSCLNPVIYVFAGKLFR 283
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
377-631 1.32e-04

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 44.42  E-value: 1.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 377 NMTVLFVllTSRYK-LTVP-RFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIdwqtgsgCSTAGFFTVFASELSV 454
Cdd:cd15076   18 NAIVLFV--TIKYKkLRQPlNYILVNISLAGFIFCIFSVFPVFVASAQGYFFFGRTV-------CALEAFVGSLAGLVTG 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 455 YTLTVITLERWHTITYAIHlDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSI---CFP--MDVETTL-SQVYI 528
Cdd:cd15076   89 WSLAFLAFERYIVICKPFG-NFRFGSKHALGAVVATWIIGIGVSLPPFFGWSRYIPEGLqcsCGPdwYTVGTKYrSEYYT 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 529 LTILILN-VVAFFIICACYIKIYFAVR-----NPELMATNKDTKIAKKMAILIFTDF-TCMAPIsffaisAAFKVPLITV 601
Cdd:cd15076  168 WFLFIFCfIVPLSIIIFSYSQLLGALRavaaqQQESASTQKAEREVSRMVVVMVGSFcLCYVPY------AALAMYMVNN 241
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 106067657 602 TNSKVLLVL-----FYPINSCA-NPFLYAIFTKTFQ 631
Cdd:cd15076  242 RDHGLDLRLvtipaFFSKSSCVyNPIIYCFMNKQFR 277
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
369-634 1.46e-04

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 44.47  E-value: 1.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 369 INILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFcmglyLLLIASVDSQTKGQYYNHAI---DWqtgsGC--STAG 443
Cdd:cd15357   10 IFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDL-----LVLLFGMPLEVYEMWSNYPFlfgPV----GCyfKTAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 444 FFTV-FASELSVYTLTVitlERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAmLPLVG--------------VSNY 508
Cdd:cd15357   81 FETVcFASILSVTTVSV---ERYVAILHPFRAKLNSTRERALKIIVVLWVLSVLFS-IPNTSihgiklqyfpngtlIPDS 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 509 MKVSICFPMDVETTLSQVyilTILILNVVAFFIICACYIKIYFAVRNPELMATNKDT---------KIAKKMAILIFTDF 579
Cdd:cd15357  157 ATCTVVKPLWIYNLIIQI---TSLLFYVLPMGVISVLYYLMGLKLRGDKSLEADEMNvniqrpsrkSVTKMLFVLVLVFA 233
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 580 TCMAPIS----FFAISAAFKVPLITVTN-SKVLLVLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15357  234 ICWAPFHvdrlFFSFVVEWTEPLANVFNlIHVVSGVFFYLSSAVNPIIYNLLSRRFRTAF 293
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
368-634 1.51e-04

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 44.02  E-value: 1.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDsqtkgQYYNHAIDWQtgSGCSTAGFFTV 447
Cdd:cd15054    9 LIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLN-----ALYGRWVLAR--DFCPIWYAFDV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 448 FASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLSQVY 527
Cdd:cd15054   82 MCCSASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLPIELGWHELGHERTLPNLTSGTVEGQC 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 528 ILTI-----LILNVVAFFI----ICACYIKIyfavrnpeLMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFkVPL 598
Cdd:cd15054  162 RLLVslpyaLVASCLTFFLpsgaICFTYCRI--------LLAARKALKASLTLGILLGMFFVTWLPFFVANVVQAV-CDC 232
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 106067657 599 ITVTNSKVLLVLFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15054  233 VSPGLFDVLTWLGY-CNSTMNPIIYPLFMRDFKRAL 267
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
368-504 1.57e-04

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 43.98  E-value: 1.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLtsRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTkgqYYNHAIdwQTGSGCSTAGFFTV 447
Cdd:cd15220    8 LLDLTALVGNTAVMVVIA--KTPHLRKFAFVCHLCVVDLLAALLLMPLGILSSSP---FFLGVV--FGEAECRVYIFLSV 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 106067657 448 FASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVG 504
Cdd:cd15220   81 CLVSASILTISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGLLPVLG 137
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
364-634 1.84e-04

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 43.93  E-value: 1.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLlTSRYKLTVPRFLMCNLSFADF--CMGLYLLLIASVDSQtkgqyynhaiDWQTGS-GC- 439
Cdd:cd15114    5 VLYAVVFLVGVPGNALVAWVT-GFEAKRSVNAVWFLNLAVADLlcCLSLPILAVPIAQDG----------HWPFGAaACk 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 --STAGFFTVFASelsVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLfsslIAMLPLVGVSNYMKV-SICFP 516
Cdd:cd15114   74 llPSLILLNMYAS---VLLLTAISADRCLLVLRPVWCQNHRRARLAWIACGAAWL----LALLLTVPSFIYRRIhQEHFP 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 517 MDVETTLS---------QVYILTILILNVVAFFIICACYIKIYFAVRNPElmaTNKDTKIAKKMAILIFTDFTCMAPISF 587
Cdd:cd15114  147 EKTVCVVDyggstgvewAVAIIRFLLGFLGPLVVIASCHGVLLVRTWSRR---RQKSRRTLKVVTAVVVGFFLCWTPYHV 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 106067657 588 FAISAAFKVP----LITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15114  224 VGLIIAASAPnsrlLANALKADPLTVSLAYINSCLNPIIYVVAGRGFRKSL 274
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
365-634 1.92e-04

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 43.84  E-value: 1.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 365 LIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQyynhaidWQTGSG-CSTAG 443
Cdd:cd15052    6 LLLLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSILTELFGGV-------WPLPLVlCLLWV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 444 FFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAM-LPLVGVSNYMKVSI---CFPMDv 519
Cdd:cd15052   79 TLDVLFCTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSpIPVLGIIDTTNVLNngtCVLFN- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 520 ettlsqvyILTILILNVVAFF----IICACYIKIYFAVRNpelmatnkDTKIAKKMAILIFTDFTCMAPisFFAISaaFK 595
Cdd:cd15052  158 --------PNFVIYGSIVAFFipllIMVVTYALTIRLLSN--------EQKASKVLGIVFAVFVICWCP--FFITN--IL 217
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 106067657 596 VPLITVTNSKVLLVLF-------YpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15052  218 TGLCEECNCRISPWLLsvfvwlgY-VSSTINPIIYTIFNKTFRRAF 262
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
361-633 1.96e-04

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 43.97  E-value: 1.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASvdsqtkgqyyNHAIDWQTGSG-- 438
Cdd:cd15174    2 FLPPLYWLIFLVGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADLLFLCTLPFWAT----------AASSGWVFGTFlc 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 439 --CSTAGFFTVFAselSVYTLTVITLERWHTITYAI--HLDQKLRLRHAILIMLGGWLFSSLIAMLPLV--GVSNYMKVS 512
Cdd:cd15174   72 kvVNSMYKINFYS---CMLLLTCISVDRYIAIVQATkaHNSKNKRLLYSKLVCFFVWLLSTILSLPEILfsQSKEEESVT 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 513 ICF----PMDVETTLSQVYILTILILNVVAFFIICACYIKIYfavrnPELMATNKDTK-IAKKMAILIFTDFT-CMAPIS 586
Cdd:cd15174  149 TCTmvypSNESNRFKVAVLALKVTVGFFLPFVVMVICYTLII-----HTLLQAKRFQKhKALKVIIAVVTVFVlSQLPYN 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 106067657 587 FFAISAAFKVPLITVTNSKVL--LVLFYPI-------NSCANPFLYAIFTKTFQRD 633
Cdd:cd15174  224 SILLIKTINAYNITITDCATSqnLDIAGQVtqsiaflHSCLNPFLYVFVGVRFRKD 279
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
362-632 2.33e-04

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 43.61  E-value: 2.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 362 LRVLIWLINILAIMGNMTVLFVllTSRYK-LTVP-RFLMCNLSFADFCMGLYLLLIaSVDSQTKGqYYNHAidwqtGSGC 439
Cdd:cd15075    3 LSIIMAVFSIASVVLNATVIIV--TLRHKqLRQPlNYALVNLAVADLGTTVFGGLL-SVVTNAVG-YFNLG-----RVGC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 STAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQkLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSI---CFP 516
Cdd:cd15075   74 VLEGFAVAFFGIAALCTVAVIAVDRLFVVCKPLGTLT-FQTRHALAGIASSWLWSLIWNTPPLFGWGSYQLEGVmtsCAP 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 517 MDVETTLSQV-YILT-ILILNVVAFFIICACYIKIYFAVRNPELM------ATNK-DTKIAKKMAILIFTDFTCMAPISF 587
Cdd:cd15075  153 DWYSRDPVNVsYILCyFSFCFAIPFAIILVSYGYLLWTLRQVAKLgvaeggSTAKaEVQVARMVVVMVMAFLLCWLPYAA 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 106067657 588 FAISAAFK-----VPLItvtnsKVLLVLFYPINSCANPFLYAIFTKTFQR 632
Cdd:cd15075  233 FALTVVSKpdvyiNPLI-----ATVPMYLAKSSTVYNPIIYIFMNKQFRD 277
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
362-634 2.42e-04

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 43.65  E-value: 2.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 362 LRVLIW-LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIdwqtgsgCS 440
Cdd:cd15979    2 VRILLYsVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVI-------CK 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 441 TAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIaMLPLVGVSnymkVSICFPMDVE 520
Cdd:cd15979   75 AVAYLMGVSVSVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLI-MIPYPVYS----VTVPVPVGDR 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 521 TTLSQV-------------YILTILILnvvaFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISF 587
Cdd:cd15979  150 PRGHQCrhawpsaqvrqawYVLLLLIL----FFIPGVVMIVAYGLISRELYRGLLAKKRVIRMLVVIVAMFFLCWLPIFS 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 106067657 588 FAISAAFKVPLI--TVTNSKVLLV-LFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15979  226 ANTWRAFDPLSAhrALSGAPISFIhLLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
361-626 2.54e-04

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 43.42  E-value: 2.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLtsRYK--LTVPRFLMCNLSFADFCMGLyLLLIASVDsqtkgqYY-NHAIDWQTG- 436
Cdd:cd15204    2 VLGVVYVLIMLVCGVGNLLLIAVLA--RYKklRTLTNLLIANLALSDFLVAV-FCLPFEMD------YYvVRQRSWTHGd 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 437 SGCSTAGFFTVFASELSVYTLTVITLERWHTITyaIHLDQKLRLRHAILIMLGGWLFSSLIAM--------LPLVGVSNy 508
Cdd:cd15204   73 VLCAVVNYLRTVSLYVSTNALLVIAIDRYLVIV--HPLKPRMKRRTACVVIALVWVVSLLLAIpsavysktTPYANQGK- 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 509 mkvSIC---FPMDVEtTLSQVYILTILILN-VVAFFIICACYIKIYFAV--------RNPELMATNKDTKIAKKMAILIF 576
Cdd:cd15204  150 ---IFCgqiWPVDQQ-AYYKAYYLFLFVLEfVLPVLIMTLCYLRIVRKVwfrrvpgqQTEQIRRRLRRRRRKVRLLVVIL 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 106067657 577 TDFT-CMAPISFFAISAAFKVPLITVtnSKVLLVLFYPI------NSCANPFLYAIF 626
Cdd:cd15204  226 TAFVlCWAPYYGYAIVRDFFPTLLSK--EKLNTTIFYIVealamsNSMINTVVYVAF 280
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
361-632 3.10e-04

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 43.25  E-value: 3.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADfcmglyLLLIASVDSQTkgqyYNHAIDWQTG---- 436
Cdd:cd15187    2 FLPVLYCLLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASD------LLFVFSLPFQA----YYLLDQWVFGnamc 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 437 ---SGCSTAGFFTvfaselSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLfSSLIAMLPLV---GVSNYMK 510
Cdd:cd15187   72 kivSGAYYIGFYS------SMFFITLMSIDRYLAIVHAVYALKVRTASHGTILSLALWL-VAILASVPLLvfyQVASEDG 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 511 VSICFPMDVETTLS-------QVYILTILIlnvvAFFIICACYIKIyfaVRNPELMATNKDTKIAKKMAILIFTDFTCMA 583
Cdd:cd15187  145 RLQCIPFYPGQGNSwkvftnfEVNILGLLI----PFSILIFCYHNI---LRNLRRCHNQNKTKAIKLVFIVVIVFFLFWT 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 106067657 584 PISFFAISAAFKVPLI---TVTNSKVLLVLFYP-----INSCANPFLYAIFTKTFQR 632
Cdd:cd15187  218 PFNVVLFLDSLHSLHIidgCQNSQRLTLALHLTetisfTHCCLNPVIYAFVGEKFKK 274
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
364-634 3.46e-04

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 42.93  E-value: 3.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADfcmglyLLLIASVDSQTKGQYYNHaidWQTGSG-CSTA 442
Cdd:cd15092    5 VVYLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALAD------TLVLLTLPFQGTDIFLGF---WPFGNAlCKTV 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 443 GFFTVFASELSVYTLTVITLERWHTITYAIH-LDqkLRLRH-AILIMLGGWLFSSLIAMLPLVGVS-----NYMKVSICF 515
Cdd:cd15092   76 IAIDYYNMFTSTFTLTAMSVDRYVAICHPIKaLD--VRTPHkAKVVNVCIWALASVVGVPVMVMGSaqvedEEIECLVEI 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 516 PmDVETTLSQVYILTILILN-VVAFFIICACYIKIYFAVRNPELMATNKDT-----KIAKKMAILIFTDFTCMAPISFFA 589
Cdd:cd15092  154 P-TPQDYWDPVFGICVFLFSfIIPVLIISVCYSLMIRRLRGVRLLSGSKEKdrnlrRITRLVLVVVAVFVGCWTPIQIFV 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 106067657 590 ISAAFKVPLITVTNSKVL---LVLFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15092  233 LAQGLGVQPSSETAVAILrfcTALGY-VNSSLNPVLYAFLDENFKACF 279
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
362-625 3.61e-04

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 42.94  E-value: 3.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 362 LRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLL--LIASVDSQTKGQYYNhaidwqtgsGC 439
Cdd:cd15938    3 LFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCpkMLVDFLSQRKAISYE---------AC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 STAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIM----LGGWLFSS----LIAMLPLVGVSNYMKV 511
Cdd:cd15938   74 IAQLFFLHFVGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVaaswAGGFLHSIvqtlLTIQLPFCGPNQVNNF 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 512 SICFPMDVETTLSQVYILTIL------ILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFtdftcMAPI 585
Cdd:cd15938  154 FCDVPPVIKLACTDTCVTELLmvsnsgLISTVCFVVLVTSYTTILVTIRSTEGRRKALSTCASHLMVVTLF-----FGPC 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 106067657 586 SFFaisaaFKVPLITVTNSKVLLVLFYPINSCANPFLYAI 625
Cdd:cd15938  229 IFI-----YARPFSTFPVDKHVSVLYNVITPMLNPLIYTL 263
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
437-634 3.78e-04

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 42.85  E-value: 3.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 437 SGCSTAGFFTvfaselSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPL-------------V 503
Cdd:cd15120   76 NSTLSVGMFT------SVFLLTAISLDRYLLTLHPVWSRQHRTNRWASAIVLGVWISAILLSIPYLafretrldekgktI 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 504 GVSNYMKVSICFPMDVETTLSQVY----ILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIakkMAILIFTDF 579
Cdd:cd15120  150 CQNNYALSTNWESAEVQASRQWIHvamfVFRFLLGFLLPFLIITFCYVRMALKMKERGLARSSKPFKV---MFTAVVSFF 226
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 106067657 580 TCMAPISFF-AISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15120  227 VCWLPYHLHsGLVLTRGRPPSLTDITLLLTVGTTCFNTCFTPVLYLFVGENFKKVL 282
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
361-632 3.93e-04

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 42.98  E-value: 3.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASvdsqtkgqYYNHAIDWQTGSG-C 439
Cdd:cd15377    2 YLPAVYILVFITGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIF--------YYFNKTDWIFGDAmC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 STAGFftVFASEL--SVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSsLIAMLPLVGVSNYM----KVSI 513
Cdd:cd15377   74 KLQRF--IFHVNLygSILFLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVWLIV-VVAISPILFYSGTGvrknKTIT 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 514 CFPMDVETTLSQVYI---LTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAI 590
Cdd:cd15377  151 CYDTTSDEYLRSYFIysmCTTVAMFCVPFILILGCYGLIVRALIYKDMKYTEENNAPLRRKSIYLVIIVLTVFAVSYLPF 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 106067657 591 SAA----------FKVPLITVTNSKVLLVL-----FYPINSCANPFLYAIFTKTFQR 632
Cdd:cd15377  231 HVMktlnlrarldFQTPAMCAFNDRVYATYqvtrgLASLNSCVDPILYFLAGDTFRR 287
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
371-634 4.98e-04

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 42.45  E-value: 4.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 371 ILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFcmglylLLIASVDSQTkgQYYNHAIDWQTGSGCSTAGFFTVFAS 450
Cdd:cd15200   12 VLGLVGNGIALFIFCFHRRPWKSNTMYLLSLVVADF------FLIINLPFRI--DYYLRNEVWRFGATACQVNLFMLSMN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 451 EL-SVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMlPLVGVSNYMKVSICFPMDVETTLSQVYIL 529
Cdd:cd15200   84 RTaSIVFLTAIALNRYLKVVHPHHQLSKASVGCAAKVAAGLWILILLLNI-HLLLLDHVQSNSTCLSYDHGTDPSASDRW 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 530 TiLILNVVAFF----IICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAIS--AAFKVPLITVTN 603
Cdd:cd15200  163 H-RILFFLEFFlplgIILFCIFSIILTLKQRKLAKQAGPQRAVKVLAVIVLVYTVCFLPSILFALAslVAFKVSQCRSLD 241
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 106067657 604 SKVLL----VLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15200  242 LCTQLfhgsLAFTYLNSALDPVLYCFSSPSFLNQS 276
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
361-549 5.09e-04

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 42.51  E-value: 5.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADfcmglyLLLIASVDSQT----KGQYYNHAIdwqtg 436
Cdd:cd15186    2 FLSIFYSLVFAFGLVGNLLVVLALTNSGKSKSITDIYLLNLALSD------LLFVATLPFWThyliNEWGLHNAM----- 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 437 SGCSTAGFFTVFASelSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLvgVSNYMKVSICFP 516
Cdd:cd15186   71 CKLTTAFFFIGFFG--GIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAVPQF--MFTKMKENECLG 146
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 106067657 517 mDVETTLSQVY-ILTILILNVVAFF----IICACYIKI 549
Cdd:cd15186  147 -DYPEVLQEIWpVLRNVELNFLGFLlpllIMSYCYFRI 183
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
368-631 5.50e-04

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 42.56  E-value: 5.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADfcmgLYLLLIASVDSQTKGQYYnhaiDWQTGSG-CSTAGFFT 446
Cdd:cd15131    9 LLFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSD----LLIFLCMPLDLYRLWQYR----PWNFGDLlCKLFQFVS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 447 VFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIA--MLPLVGV-----SNYMKVSICFPMD- 518
Cdd:cd15131   81 ESCTYSTILNITALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLSAgpIFVLVGVehengTNPIDTNECKATEy 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 519 -VETTLsqvyiLTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIA-------------KKMAILIFTDFTCMAP 584
Cdd:cd15131  161 aVRSGL-----LTIMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRRENIGPnashrdknnrqtvKMLAVVVFAFVLCWLP 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 106067657 585 --ISFFAISAAFK-----VPLITVTNSKVLLVLFYpINSCANPFLYAIFTKTFQ 631
Cdd:cd15131  236 fhVGRYLFSKSFEagsleIALISQYCNLVSFVLFY-LSAAINPILYNIMSKKYR 288
7tmA_LPAR1_Edg2 cd15344
lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial ...
371-634 5.57e-04

lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341348 [Multi-domain]  Cd Length: 273  Bit Score: 42.32  E-value: 5.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 371 ILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGL-YLLLIASVDSQTKGQYYNhaiDWQTGSGCSTAGFFTvfa 449
Cdd:cd15344   12 IFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLaYFYLMFNTGPNTRRLTVS---TWLLRQGLIDTSLTA--- 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 450 selSVYTLTVITLERwHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMdvETTLSQVYIL 529
Cdd:cd15344   86 ---SVANLLAIAIER-HITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNM--APLYSDSYLV 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 530 TILILNVVAFFIICACYIKIYFAVRNPELMAT--------NKDTKIA--KKMAILIFTDFTCMAPiSFFAISAAFKVPLI 599
Cdd:cd15344  160 FWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSrhssgprrNRDTMMSllKTVVIVLGAFIICWTP-GLVLLLLDVCCPQC 238
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 106067657 600 TVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15344  239 DVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 273
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
361-633 5.87e-04

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 42.42  E-value: 5.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVdsqtkgqyYNHAIDWQTGSG-C 439
Cdd:cd15397    2 FLVVSYSLVMAVGLLGNICLICVIARQKEKTNVTNILIANLSFSDILVCLVCLPFTVV--------YTLMDYWIFGEVlC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 STAGFFTVFASELSVYTLTVITLERWHTItyaIH-LDQKLRLRHAILIMLGGWLFSSLIAmLPLVGVS-----NYMKVSI 513
Cdd:cd15397   74 KMTPFIQCMSVTVSILSLVLIALERHQLI---INpTGWKPSVSQAYLAVVVIWMLACFIS-LPFLAFHiltdePYKNLSH 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 514 CFP------MDVETTLSQ----VYILTILILNVVA-FFIICACYIKIYFAVRNPELMATNKDT---------KIAKKMAI 573
Cdd:cd15397  150 FFApladkaVCTESWPSEhhklAYTTWLLLFQYCLpLLFILVCYLRIYLRLRRRKDMLERRGEynrraghskRINVMLVS 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 106067657 574 LIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPI---NSCANPFLYAIFTKTFQRD 633
Cdd:cd15397  230 LVAAFALCWLPLNVFNAIADWNHEAIPHCQHNLIFSLCHLAamaSTCVNPIIYGFLNSNFKKE 292
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
368-634 5.89e-04

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 42.58  E-value: 5.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFcmgLYLLLIASVDSQtkgQYYnhAIDWQTGS-GCSTAGFFT 446
Cdd:cd15124    9 IIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDL---LLLVTCAPVDAS---RYL--ADEWLFGRvGCKLIPFIQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 447 VFASELSVYTLTVITLERWHTIT-----YAIHLDQKLRLRHAILimlggWLFSSLIA--------MLPLVGVSNYMKVSI 513
Cdd:cd15124   81 LTSVGVSVFTLTALSADRYKAIVrpmdiQASNALMKICLKAALI-----WILSMLLAipeavfsdLHPFYDKSTNKTFVS 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 514 CFPMDVETTLSQVY--ILTILILNVVAFFIICACYikiYFAVRNPELMATN----------KDTKIAKKMA--ILIFTDF 579
Cdd:cd15124  156 CAPYPHSNELHPKIhsMASFLIFYVIPLSIISVYY---YFIAKNLIRSAYNlpvegnvhvrRQIESRKRLAktVLVFVGL 232
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 106067657 580 --TCMAPISFFAISAAFKVPLITVTN----SKVLLVLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15124  233 faFCWLPNHIIYLYRSYHYSEVDTSMlhfvSSICARILAFTNSCVNPFALYLLSKSFRKQF 293
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
361-634 6.46e-04

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 41.96  E-value: 6.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIdwqtgsgCS 440
Cdd:cd15331    2 LTSIILGLLILATIIGNVFVIAAILLERSLQGVSNYLILSLAVADLMVAVLVMPLSAVYEVSQHWFLGPEV-------CD 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 441 TAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQklRLRHAILIMLGG-WLFSSLIAMLPLVGVSNymkvsICFPMDV 519
Cdd:cd15331   75 MWISMDVLCCTASILHLVAIALDRYWAVTNIDYIRR--RTAKRILIMIAVvWFVSLIISIAPLFGWKD-----EDDLDRV 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 520 ETT----LSQVYILTILIlNVVAFFI----ICACYIKIYFAVRnpelmatnKDTKIAKKMAILIFTDFTCMAPisFFAIs 591
Cdd:cd15331  148 LKTgvclISQDYGYTIFS-TVGAFYVplllMIIIYWKIYQAAK--------RERKAARTLAIITGAFVVCWLP--FFLV- 215
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 106067657 592 aAFKVPLITVTN-SKVLLVLFYPI---NSCANPFLYAIFTKTFQRDF 634
Cdd:cd15331  216 -ALVMPFCGAWQiSRFLESFFLWLgyfNSLLNPIIYTIFSPDFRGAF 261
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
364-634 6.54e-04

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 42.23  E-value: 6.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSqtkgqyynhaIDWQTG-SGCSTA 442
Cdd:cd15069    5 ALELIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITIS----------LGFCTDfHSCLFL 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 443 GFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSIC--FPMDVE 520
Cdd:cd15069   75 ACFVLVLTQSSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGLTPFLGWNKAMSATNNstNPADHG 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 521 TTLSQVYIlTILILNVVA--------FF--------IICACYIKIYFA----VRNPELMATNKDT-----KIAKKMAILI 575
Cdd:cd15069  155 TNHSCCLI-SCLFENVVPmsymvyfnFFgcvlppllIMLVIYIKIFLVacrqLQRTELMDHSRTTlqreiHAAKSLAIIV 233
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 106067657 576 FTDFTCMAPISFFAISAAF-----KVPLITVTNSKVLLVlfyPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15069  234 GIFALCWLPVHILNCITLFqpefsKSKPKWAMNVAILLS---HANSVVNPIVYAYRNRDFRYTF 294
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
361-555 6.81e-04

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 41.94  E-value: 6.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLfVLLTSRYKLTVPR-FLMCNLSFADFCMG--LYLLLIASVDSQTKGQYYNhaidwqtgs 437
Cdd:cd15936    2 FLFLVFLLVYLTTWLGNLLII-ITVISDPHLHTPMyFLLANLAFLDISFSsvTAPKMLSDLLSQTKTISFN--------- 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 438 GCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFS--------SLIAMLPLVGvSNYM 509
Cdd:cd15936   72 GCMAQMFFFHFTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGfahsivqvALLLQLPFCG-PNVL 150
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 106067657 510 KVSIC-FPMDVETTLSQVYILTILI------LNVVAFFIICACYIKIYFAVRN 555
Cdd:cd15936  151 DNFYCdVPQVIKLACTDTFLLELLMvsnsglVTLLIFFILLISYTVILVKIRT 203
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
368-549 8.01e-04

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 42.05  E-value: 8.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVL--LTSRYKLTVPRFLMCNLSFAD--FCMGLYLLLIasvdsqtkgqYYNHAIDW-QTGSGCSTA 442
Cdd:cd15147    9 IIFVLGLIANCYVLWVFarLYPSKKLNEIKIFMVNLTIADllFLITLPFWIV----------YYHNEGNWiLPKFLCNVA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 443 GFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWlFSSLIAMLPLVGVSNYMKVSI-------CF 515
Cdd:cd15147   79 GCLFFINTYCSVAFLGVISYNRYQAVTRPIKTAQSTTRKRGIIISVAIW-VIIVASASYFLFMDSTNTVKIdsgnftrCF 157
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 106067657 516 PMDVETTLSQVYILTILI--LNVVAFFIICACYIKI 549
Cdd:cd15147  158 EGYEKDNSKPVLIIHFIIigLFFLVFLLILVCNLVI 193
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
359-553 8.47e-04

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 41.82  E-value: 8.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 359 YDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLL--LIASVDSQTKGQYYnhaidwqtg 436
Cdd:cd15235    1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVpkMLANLLSGSKTISY--------- 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 437 SGCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSnymKVSIC-- 514
Cdd:cd15235   72 AGCLAQMYFFIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMS---RLSFCgs 148
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 106067657 515 -----FPMDVETTL----SQVYILTILILN------VVAFFIICACYIKIYFAV 553
Cdd:cd15235  149 neiphFFCDLQPLLklscSDTSLNELLIFTegavvvLGPFLLIVLSYARILAAV 202
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
361-632 8.71e-04

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 41.66  E-value: 8.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVL-LTSRYKLTVPRFLMcNLSFADFCMGLYLLLIASVDSQTKgqyynhaiDWQTGSG- 438
Cdd:cd15193    2 YIPILYLIIFFTGLLGNLFVIALMsKRSTTKRLVDTFVL-NLAVADLVFVLTLPFWAASTALGG--------QWLFGEGl 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 439 CSTAGFFTVFASELSVYTLTVITLERWHTITyAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMD 518
Cdd:cd15193   73 CKLSSFIIAVNRCSSILFLTGMSVDRYLAVV-KLLDSRPLRTRRCALITCCIIWAVSLVLGIPSLVYRNLINESVCVEDS 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 519 VETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAIlIFT----------DFTCMAPISFF 588
Cdd:cd15193  152 SSRFFQGISLATLFLTFVLPLIVILFCYCSILVRLRRHFHGAKRTGRRRRNSLRI-VFAivtafvlswlPFNTLKAVRLL 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 106067657 589 AISAAFKVPLITVTNSKVLLVL---FYPINSCANPFLYAIFTKTFQR 632
Cdd:cd15193  231 LELGGGVLPCHTTVAIRQGLTItacLAFVNSCVNPLIYSLLDRHFRR 277
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
378-631 8.76e-04

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 41.74  E-value: 8.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 378 MTVLFVLLTSRYK--LTVPRFLMCNLSFADfcmglylLLIASVDSQTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVY 455
Cdd:cd15077   17 INVLTIICTIKYKklRSHLNYILVNLAVAN-------LIVVCFGSTTAFYSFSQMYFVLGPLACKIEGFTATLGGMVSLW 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 456 TLTVITLERWHTITYAIHlDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSI---CFPmDVETT----LSQVYI 528
Cdd:cd15077   90 SLAVVAFERFLVICKPLG-NFTFRGTHAIIGCIATWVFGLAASLPPLFGWSRYIPEGLqcsCGP-DWYTTnnkwNNESYV 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 529 LTILILNV-VAFFIICACYIKIYFAVR-----NPELMATNKDTKIAKKMAILIFTDF-TCMAPISFFAI------SAAFK 595
Cdd:cd15077  168 MFLFCFCFgVPLSIIVFSYGRLLLTLRavakqQEQSASTQKAEREVTKMVVVMVLGFlVCWLPYASFALwvvtnrGEPFD 247
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 106067657 596 VPLITVTNskvllvLFYPINSCANPFLYAIFTKTFQ 631
Cdd:cd15077  248 LRLASIPS------VFSKASTVYNPVIYVFMNKQFR 277
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
372-631 8.85e-04

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 41.73  E-value: 8.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 372 LAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADfcmglyLLLIAsvDS-----QTKGQYYNHAIDwqtgsgCSTAGFFT 446
Cdd:cd14989   13 IGFIGNILILVVNLSFREKMTIPDLYFVNLAVAD------LILVA--DSlievfNLNEKYYDIAVL------CTFMSLFL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 447 VFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPL--VGVSNYMKVSICFpmdveTTLS 524
Cdd:cd14989   79 QINMYSSIFFLTWMSFDRYIALAKVMKSSPLRTMQHARLSCGLIWMASISATLLPFtaVQAQHTGEVHFCF-----ADVR 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 525 QVYILTILILNVVAFFIICACYIKIyfaVRnpELMATNKD-------TKIAKKMAILIFTDFTCMAPISFFAISAAFKVP 597
Cdd:cd14989  154 EIQWLEVTLGFIIPFSIIGLCYSLI---VR--VLVRAQKHrrlrprrQKALRMILVVVLVFFICWLPENVFISIQLLQGT 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 106067657 598 LITVTNSKVLLVLFYPI-----------NSCANPFLYAIFTKTFQ 631
Cdd:cd14989  229 QEPSESYDESFRHNHPLtghivnlaafsNSCLNPLIYSFLGETFR 273
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
364-634 9.61e-04

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 41.73  E-value: 9.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVdsqtkgqyYNHAIDWQTGSG-CSTA 442
Cdd:cd15301    5 IVAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTV--------YTALGYWPLGYEvCDTW 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 443 GFFTVFASELSVYTLTVITLERWHTITYAIHLDQKlRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMD---V 519
Cdd:cd15301   77 LAIDYLASNASVLNLLIISFDRYFSVTRPLTYRAR-RTTKKAAVMIASAWIISLLLWPPWIYSWPYIEGKRTVPAGtcyI 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 520 ETTLSQVYIL--TILILNVVAFFIICACYIKIYfavRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVP 597
Cdd:cd15301  156 QFLETNPYVTfgTALAAFYVPVTIMCILYWRIW---RETKKRQKKQESKAAKTLSAILLAFIVTWTPYNVLVLIKAFFPC 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 106067657 598 LITVTNskVLLVLFYP---INSCANPFLYAIFTKTFQRDF 634
Cdd:cd15301  233 SDTIPT--ELWDFSYYlcyINSTINPLCYALCNAAFRRTY 270
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
453-634 1.01e-03

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 41.55  E-value: 1.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 453 SVYTLTVITLERWHTITYAI--HLDQKLRLRHAILIMLggWLFSSLIAMLPLVGVSNYMKVSICFPMDvETTLSQVYILT 530
Cdd:cd15961   83 SVCSLLAITVDRYLSLYYALtyNSERTVTFTYVMLVLL--WGASICLGLLPVMGWNCLADESTCSVVR-PLTKNNAAILS 159
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 531 ILILnvVAFFIICACYIKI---------YFAVRNPELMATNKDT--KIAKKMAILIFTDFTCMAPISFFAISAAFKVPli 599
Cdd:cd15961  160 VSFL--LMFALMLQLYIQIckivmrhahQIALQHHFLATSHYVTtrKGVSTLAIILGTFAACWMPFTLYSLIADYTYP-- 235
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 106067657 600 TVTNSKVLLVLFYpiNSCANPFLYAIFTKTFQRDF 634
Cdd:cd15961  236 SIYTYATLLPATY--NSIINPVIYAFRNQEIQKAL 268
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
368-631 1.03e-03

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 41.69  E-value: 1.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDS-QTKGQYYNhaidwqtgsgCSTAGFFT 446
Cdd:cd15070    9 LIGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIVVSlGVTIHFYS----------CLFMSCLL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 447 VFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSnyMKVSIcfpMDVETTLSQV 526
Cdd:cd15070   79 VVFTHASIMSLLAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGLTPMFGWN--RKPSL---ESVNTTPLQC 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 527 YILTILILNVVAFF-----------IICACYIKIYFAVRNP--ELMATNKDT--------KIAKKMAILIFTDFTCMAPI 585
Cdd:cd15070  154 QFTSVMRMDYMVYFsfftwiliplvIMCALYVDIFYIIRNKlsQNATGFRETgafygrefKTAKSLALVLFLFAVCWLPL 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 106067657 586 SFFAISAAF--KVPLITVtnskVLLVLFYPINSCANPFLYAIFTKTFQ 631
Cdd:cd15070  234 SIINCVVYFnpKVPKIAL----YLGILLSHANSMMNPIVYACKIKKFK 277
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
361-625 1.66e-03

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 40.98  E-value: 1.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFL-MCNLSFADFCMGLyLLLIASVDSQTKGQYYNHAIDWQTGSGC 439
Cdd:cd15341    2 AIAVLCTLCGLLCILENVAVLYLILSSPKLRRKPSYLfIGSLALADFLASV-VFACSFVDFHVFHGVDSSAIFLLKLGGV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 STAgfFTVfaselSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSIC---FP 516
Cdd:cd15341   81 TMS--FTA-----SLGSLLLMAFDRYVCIYYPSEYKALVTRKRALVALAVMWVLTALIAYLPLMGWNCCPLNSPCselFP 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 517 MdvettLSQVYILTILILNVVAFFIICACYIKI---------YFAVRN----PELMATNKDTKIAKKMAILIFTDFTCMA 583
Cdd:cd15341  154 L-----IPNDYLLSWLLLVAILLSGIIYTYGHVlwkahkhvvYMEKHQdqqgPGNARMRLDVRLAKTLGLVLAVLLICWS 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 106067657 584 PISFFAISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAI 625
Cdd:cd15341  229 PVLALMMHSLFTSLSDHIKKAFAFCSTLCLVNSMVNPIIYAL 270
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
368-632 1.93e-03

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 40.80  E-value: 1.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFAD--FCMGLyllliasvdsQTKGQYYNHAIDWQTGSG-CSTAGF 444
Cdd:cd15159    9 LILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDilFTLAL----------PGRIAYYALGFDWPFGDWlCRLTAL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 445 FTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAM-LPLVGVSNYMKVSI-C--FPmDVE 520
Cdd:cd15159   79 LFYINTYAGVNFMTCLSVDRYIAVVHPLRRHRLRKVKVVRYICVFVWVLVFLQTLpLLFMPMTKEMGGRItCmeYP-NFE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 521 TTLSQVYILtiLILNVVAFF----IICACYIKI----YFAVRNPELMATNKDTKIAKKMAILIFTDFT-CMAP----ISF 587
Cdd:cd15159  158 KIKRLPLIL--LGACVIGFGvpvgIILFCYSQItlklCRTAKENPLTEKSGHHKKACNVILLVLLVFVvCFSPyhlnIIQ 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 106067657 588 FAIS-----------AAFKVPL-ITVTnskvllvlFYPINSCANPFLYAIFTKTFQR 632
Cdd:cd15159  236 FMIRkllyqpscselKAFKISLqITVC--------LMNLNCCLDPFIYFFACKGYKK 284
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
453-634 2.05e-03

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 40.88  E-value: 2.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 453 SVYTLTVITLERWHTITYAIHLDQKLR--LRHAILIMLGGWLFSSLIaMLPLV---GV-SNYMKVSIC---FPMDVETTL 523
Cdd:cd15087   86 SIYFLTVMSVDRYLVVLATVRSRRMPYrtYRAAKIVSLCVWLLVTII-VLPFTvfaGVySNELGRKSCvlsFPSPESLWF 164
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 524 SQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKD-TKIAKKMAILIFTDFT----CMAPISFFAISAAF---- 594
Cdd:cd15087  165 KASRIYTLVLGFAIPVSTICILYTMMLYKLRNMRLNSNAKAlDKAKKKVTLMVLVVLAvclfCWTPFHLSTVVALTtdlp 244
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 106067657 595 KVPLItVTNSKVLLVLFYPiNSCANPFLYAIFTKTFQRDF 634
Cdd:cd15087  245 QTPLV-IGISYFITSLSYA-NSCLNPFLYAFLDDSFRKSF 282
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
371-634 2.09e-03

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 40.89  E-value: 2.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 371 ILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLL---LIASVDSQtkgqyynhaidWQTGSgcstagFFTV 447
Cdd:cd15317   12 LITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMpfsMIRTVETC-----------WYFGD------LFCK 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 448 FASEL-------SVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLV------GVSNYMKVSIC 514
Cdd:cd15317   75 FHTGLdlllcttSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVPGIYTFGLIYtgandeGLEEYSSEISC 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 515 FPmDVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATN------------------KDTKIAKKMAILIF 576
Cdd:cd15317  155 VG-GCQLLFNKIWVLLDFLTFFIPCLIMIGLYAKIFLVARRQARKIQNmedkfrsseensskasasRERKAAKTLAIVMG 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 106067657 577 TDFTCMAPISFFAISAAFkVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15317  234 IFLFCWLPYFIDTIVDEY-SNFITPAIVFDAVIWLGYFNSAFNPFIYAFFYPWFRKAF 290
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
368-632 2.20e-03

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 40.48  E-value: 2.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLiasvdsqtKGQYYNHAiDWQTGSGCSTAGFFTV 447
Cdd:cd15152    9 VILIPGLIGNVLALWVFYAYVKETKRAVIFMINLAIADLLQVLSLPL--------RIFYYLNK-SWPFGKFLCMFCFYLK 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 448 FASEL-SVYTLTVITLERWHTITYAIHLDQKLRlRHAILIMLGGWLFSSLIAML-PLVGVSNYMKVSICFP----MDVET 521
Cdd:cd15152   80 YVNMYaSIYFLVCISVRRCLYLIYPFRYNDCKR-KCDVYISIAGWLVVCVGCLPfPLLRQSQDTNPTCCFAdlplRNVGL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 522 TLSqVYILTI--LILNVVAFFIICACYIKIYFAVRNPELMATNK-DTKIAKKMAILIFTDF-TCMAPISF-FAISAAFKV 596
Cdd:cd15152  159 TTS-VIMLTIaeLTGFVTPLLIVLYCSWKTVMSLREKTPVLQDLgEKKKALKMILTCAVVFlICFAPYHIsFPLDFLVKS 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 106067657 597 PLITVTNSKVLLVLFYPI-------NSCANPFLYAIFTKTFQR 632
Cdd:cd15152  238 NKIKSCTARKVILIFHPValclaslNSCLDPVIYYFTTDEFKR 280
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
368-634 2.58e-03

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 40.56  E-value: 2.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADfcmglyLLLIASVdsQTKGQYYNHAIDWQTGS-GCSTAGFFT 446
Cdd:cd15921    9 LIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISD------LLLVCTL--PLRLTYYVLNSHWPFGDiACRIILYVL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 447 VFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLiAMLPLVGVSNYMK---VSICF--PMDVET 521
Cdd:cd15921   81 YVNMYSSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGL-ASSPLLFAKSKQHdegSTRCLelAHDAVD 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 522 TLSQVYILTILILNVVAFFIICACYIKIYFAVRNPElmATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLIT- 600
Cdd:cd15921  160 KLLLINYVTLPVGFVVPFMTVIFCYIFIIKNLLKPS--PALGRTRPSRRKACALIIISLGIFLVCFLPYHIVRTIHLITe 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 106067657 601 ------------VTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15921  238 rqikescgyilrVRKAAVITLCLAASNSCFDPLLYFFVGENFRSRL 283
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
361-584 2.67e-03

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 40.14  E-value: 2.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIAsVDSqtkgqyynhAIDWQTGS--G 438
Cdd:cd15179    2 FLPTVYSIIFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLFVLTLPFWA-VDA---------AANWYFGNflC 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 439 CSTAGFFTV-FASelSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLV--GVSNYMKVSIC- 514
Cdd:cd15179   72 KAVHVIYTVnLYS--SVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWLPALLLTVPDLVfaKVSELDDRYICd 149
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 106067657 515 --FPMDVETTLSQVY-ILTILILNVVAFFIICACYIKIyfaVRNPELMATNKDTKIAKKMAILIFTDFTCMAP 584
Cdd:cd15179  150 riYPEDTFELWVVAFrFQHILVGLVLPGLVILTCYCII---ISKLSHSKGHQKRKALKTTVILILAFFACWLP 219
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
365-502 2.91e-03

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 40.33  E-value: 2.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 365 LIWLINILAIMGNMTVLFVLLTSRY-KLTVPRFLMCNLSFADFCMGLYLLLIASVdSQTKGQyynhaidWQTGSGCSTAG 443
Cdd:cd15319    6 LLSLLILWTLLGNILVCAAVVRFRHlRSKVTNIFIVSLAVSDLFVALLVMPWKAV-AEVAGY-------WPFGAFCDVWV 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 106067657 444 FFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPL 502
Cdd:cd15319   78 AFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTQRVALVMISVAWTLSVLISFIPV 136
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
362-632 3.03e-03

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 40.23  E-value: 3.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 362 LRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHaidwqtgSGCST 441
Cdd:cd15316    3 LYIVLGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGE-------SFCTF 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 442 AGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSN-----YMKVSICFP 516
Cdd:cd15316   76 HTCCDVSFCYASLFHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWIFSLTYSFSVFYTGVNddgleELVNALNCV 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 517 MDVETTLSQVYILTILILNVVAFFIICACYIKIYFA----VRNPELMATN--------------KDTKIAKKMAILIFTD 578
Cdd:cd15316  156 GGCQIILNQNWVLVDFLLFFIPTFAMIILYGKIFLVakqqARKIEMTSSKaesssesykdrvarRERKAAKTLGITVIAF 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 106067657 579 FTCMAPISFFAISAAFkVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQR 632
Cdd:cd15316  236 LVSWLPYLIDVLIDAF-MNFITPPYIYEICCWCAYYNSAMNPLIYALFYPWFRK 288
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
368-634 3.05e-03

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 40.10  E-value: 3.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFcmgLYLLLIASVDSqtkgqYYNHAIDWQTGS-GCSTAGFFT 446
Cdd:cd14977    9 VIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDL---LLLLLCVPLNA-----YNLLTKDWLFGDvMCKLVPFIQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 447 VFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVG--VSNYMK-----VSICfPMDV 519
Cdd:cd14977   81 VTSLGVTVFSLCALSIDRYRAAVNSMPMQTIGACLSTCVKLAVIWVGSVLLAVPEAVLstVARESSldnssLTVC-IMKP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 520 ETTLSQVY--ILTILILNVvaFFIICACYIKIYFAVRNPELMATNKDTKIAKK-------------MAILIFTDFtCMAP 584
Cdd:cd14977  160 STPFAETYpkARSWWLFGC--YFCLPLAFTAVCYLLMARTLIRAAKEYTRGTKkhmkqrrqlaktvLCLVLVFAF-CWLP 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 106067657 585 ISFFAISAAFKVPLITVTNSKVLLVLFY------PINSCANPFLYAIFTKTFQRDF 634
Cdd:cd14977  237 EHISNILRATLYNEVLIDTRSTLDILDLigqflsFFNSCVNPIALYLLSEPFRRAF 292
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
364-624 3.63e-03

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 39.77  E-value: 3.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYL-LLIASVDSQTkgqyynhaidWQTG-SGCST 441
Cdd:cd14975    5 TLLSLAFAIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAVLLTLpVWIYFLATGT----------WDFGlAACKG 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 442 AGFFTVFASELSVYTLTVITLERWHTITYAiHLDQKLRLRHAIL-IMLGGWLFSSLIA--MLPLVGVSNYMKVSICFPMD 518
Cdd:cd14975   75 CVYVCAVSMYASVFLITLMSLERFLAVSRP-FVSQGWRAKALAHkVLAIIWLLAVLLAtpVIAFRHVEETVENGMCKYRH 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 519 VETTLSQVYILTILILN-VVAFFIICACYIKIYFAVRNpelMATNKDTKIAKKMAILIFTDFTCMAPISFFAI----SAA 593
Cdd:cd14975  154 YSDGQLVFHLLLETVVGfAVPFTAVVLCYSCLLRRLRR---RRFRRRRRTGRLIASVVVAFAACWLPYHVGNLlevvSEL 230
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 106067657 594 FKVPLITVTNSKVLLVLFYP------INSCANPFLYA 624
Cdd:cd14975  231 IGGSKMAGTLGKVAEAGRPIagalafLSSSINPLLYA 267
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-274 3.69e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.30  E-value: 3.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657  51 LTRLSLAYLPVKVIPSqAFRGLNEVIKIEIS--QIDSLerieANAFDNLLNLSEILIQNTKnLRYIePGAFINLPRLKYL 128
Cdd:COG4886  161 LKSLDLSNNQLTDLPE-ELGNLTNLKELDLSnnQITDL----PEPLGNLTNLEELDLSGNQ-LTDL-PEPLANLTNLETL 233
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 129 SICNTGIRKFPDVTKvFSSESNFILeicDNLHITTIPGNAfqGMNNESvTLKLYGNGFEEVQ-SHAFNGTTLTSLELKEN 207
Cdd:COG4886  234 DLSNNQLTDLPELGN-LTNLEELDL---SNNQLTDLPPLA--NLTNLK-TLDLSNNQLTDLKlKELELLLGLNSLLLLLL 306
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 106067657 208 VHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRLIATSSYSLKKLPSRETFVNLLEATLT 274
Cdd:COG4886  307 LLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
361-632 3.79e-03

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 39.84  E-value: 3.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 361 FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIasVDSQTKGQYynhaidWQTGSG-C 439
Cdd:cd15194    2 FLPILYCLVFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDFIFLVTLPLW--VDKEVVLGP------WRSGSFlC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 440 STAGFFTVFASELSVYTLTVITLERWHTITYAIhLDQKLRLRH-AILIMLGGWLFSSLIAMLPLVgvSNYMKVSICFPMD 518
Cdd:cd15194   74 KGSSYIISVNMYCSVFLLTCMSLDRYLAIVLPL-VSRKFRTKHnAKVCCTCVWMLSCLLGLPTLL--SRELKKYEEKEYC 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 519 VETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMA-------PISFF--- 588
Cdd:cd15194  151 NEDAGTPSKVIFSLVSLIVAFFLPLLSILTCYCTIIWKLCHHYQKSGKHQKKLRKSIKIVFIVVAafvfswmPFNLFkal 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 106067657 589 AISAAFKV--PLITVTNSKVLLVLFYPI---NSCANPFLYAIFTKTFQR 632
Cdd:cd15194  231 AIASGLQVevTCLPYTLAQLGMEVSAPLafaNSCANPFIYYFFDRYIRR 279
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
364-492 4.81e-03

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 39.77  E-value: 4.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILaimGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQyynhAIDWqtgSGCSTAG 443
Cdd:cd15944   21 LIIYLVNVV---GNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHK----VISF---SGCATQF 90
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 106067657 444 FFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWL 492
Cdd:cd15944   91 AFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYL 139
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
453-634 4.93e-03

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 39.55  E-value: 4.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 453 SVYTLTVITLERWHTITYAIH-LDQKLRLRhAILIMLGGWLFSSLIA---MLPLVGVSNYMKVSIC---FPmDVETTLSQ 525
Cdd:cd15089   86 SIFTLTMMSVDRYIAVCHPVKaLDFRTPAK-AKLINICIWVLSSGVGvpiMVMAVTKTPRDGAVVCmlqFP-SPSWYWDT 163
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 526 VYILTILILN-VVAFFIICACYIKIYFAVRNPELMATNKDT-----KIAKKMAILIFTDFTCMAPISFFAISAAF----K 595
Cdd:cd15089  164 VTKICVFIFAfVVPILVITVCYGLMILRLRSVRLLSGSKEKdrnlrRITRMVLVVVAAFIICWTPIHIFVIVWTLvdidR 243
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 106067657 596 VPLITVTNSKVLLVLFYpINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15089  244 RNPLVVAALHLCIALGY-ANSSLNPVLYAFLDENFKRCF 281
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
364-632 5.53e-03

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 39.41  E-value: 5.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 364 VLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADfcmgLYLLLIASVdSQTKGQYYNHAidWQTGS-GCSTA 442
Cdd:cd15198    5 IFLGVILVAGVAGNTTVLCWLCGGRRRKSRMNFLLLQLALAD----LLVIGGTAL-SQIIWELLGDR--WMAGDvACRLL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 443 GFFTVFASELSVYTLTVITLERWHtityAIHLDQKLRLRHAILIMLgGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETT 522
Cdd:cd15198   78 KLLQASARGASANLVVLLALDRHQ----AIRAPLGQPLRAWKLAAL-GWLLALLLALPQAYVFRVDFPDDPASAWPGHTL 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 523 LS-----------QVYILTILILNVVA-FFIICACYIKIYFAV------RNPELMATNKDTKI------------AK--- 569
Cdd:cd15198  153 CRgifaplprwhlQVYATYEAVVGFVApVVILGVCYGRLLLKWweranqAPGAKKPWKKPSKShlratapsalprAKvkt 232
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 106067657 570 -KMAILIFTDFT-CMAPISFFAISAAF----KVPLITVTNSKVLLVlfypINSCANPFLYAIFTKTFQR 632
Cdd:cd15198  233 lKMTLVIALLFVgCSLPYFIAELAAAFgsgdWEPEKVAAALGVMAV----ANSATNPFVFLFFNAGDCR 297
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
371-634 5.62e-03

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 39.40  E-value: 5.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 371 ILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFAD--FCMGLYLLLIASVDSQtkgqyynhaidWQTGS-GCSTAGFFTV 447
Cdd:cd15972   12 VVGLGGNTLVIYVVLRYSASESVTNIYILNLALADelFMLGLPFLAAQNALSY-----------WPFGSfMCRLVMTVDA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 448 FASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIaMLPLVGVSNYMK-VSICF-----PMDVET 521
Cdd:cd15972   81 INQFTSIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLV-VLPVVIFSGVPGgMGTCHiawpePAQVWR 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 522 TLSQVYILTililnvVAFF----IICACYIKIYFAVRNP--ELMATNKDTKIAK----KMAILIFTDFT-CMAPisFFA- 589
Cdd:cd15972  160 AGFIIYTAT------LGFFcpllVICLCYLLIVVKVRSSgrRVRATSTKRRGSErkvtRMVVIVVAAFVlCWLP--FYAl 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 106067657 590 --ISAAFKVPLITVTNSKVLLVLFYPI-NSCANPFLYAIFTKTFQRDF 634
Cdd:cd15972  232 niVNLVCPLPEEPSLFGLYFFVVVLSYaNSCANPIIYGFLSDNFKQGF 279
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
453-634 6.04e-03

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 38.99  E-value: 6.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 453 SVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGgWLFSSLIAMLPLVG---VSNYMKVSICFPMdvettLSQVYIL 529
Cdd:cd15102   86 SVFSLLAIAIERHLTMAKMKPYGASKTSRVLLLIGAC-WLISLLLGGLPILGwncLGALDACSTVLPL-----YSKHYVL 159
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 530 TILILNVVAFFIICACYIKIYFAVR-----NPELMATNKDTKIAKKMAILIFTDFTCMAPI-SFFAISAAFKVPLITVTN 603
Cdd:cd15102  160 FCVTIFAGILAAIVALYARIYCLVRasgrkATRASASPRSLALLKTVLIVLLVFIACWGPLfILLLLDVACPVKTCPILY 239
                        170       180       190
                 ....*....|....*....|....*....|.
gi 106067657 604 SKVLLVLFYPINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15102  240 KADWFLALAVLNSALNPIIYTLRSRELRRAV 270
7tmA_GPR6 cd15962
G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...
374-632 6.43e-03

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320628 [Multi-domain]  Cd Length: 268  Bit Score: 39.14  E-value: 6.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 374 IMGNMTVLFVLLTSRYKLTVPRF-LMCNLSFADFCMGLYLLLiasvdsqtkGQYYNHAIDWQTGSGCSTAGFFTVFASel 452
Cdd:cd15962   14 IACENAIVVAIIFYTPTLRTPMFvLIGSLATADLLAGCGLIL---------NFVFQYVIQSETISLITVGFLVASFTA-- 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 453 SVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVG---VSNYMKVSICFPM-DVETTLSQVYI 528
Cdd:cd15962   83 SVSSLLAITVDRYLSLYNALTYYSEKTVLGVHLMLAATWGVSLCLGLLPVLGwncLEERASCSIVRPLtKSNVTLLSASF 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 529 LTILILNVVAFFIIC--ACYIKIYFAVRN-----PELMATNKDTkiaKKMAILIFTDFTCMAPISFFAISAAFKVPliTV 601
Cdd:cd15962  163 FFIFILMLHLYIKICkiVCRHAHQIALQQhfltaSHYVATKKGV---STLAIILGTFGASWLPFAIYCVVGDHEYP--AV 237
                        250       260       270
                 ....*....|....*....|....*....|.
gi 106067657 602 TNSKVLLVLFYpiNSCANPFLYAIFTKTFQR 632
Cdd:cd15962  238 YTYATLLPATY--NSMINPIIYAYRNQEIQR 266
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
368-632 7.52e-03

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 38.96  E-value: 7.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFAD--FCMGLYLLLIasvdsqtkgqYYNHAIDWQTGSG-CSTAGF 444
Cdd:cd15158    9 VITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDllCVCTLPLRVV----------YYVHKGQWLFGDFlCRISSY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 445 FTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSI--CF-PMDVET 521
Cdd:cd15158   79 ALYVNLYCSIYFMTAMSFTRFLAIVFPVQNLNLVTVKKARIVCVGIWIFVTLTSSPFLMSGSHDTETNKtkCFePPQSNQ 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 522 TLSQVYILTILILNV---VAFFIICACYIKIYFAVRNPElMATNKDTKIAKK---MAILIFTDF-TCMAP--------IS 586
Cdd:cd15158  159 QLTKLLVLNYISLVVgfiIPFLVILICYAMIIRTLLKNT-MKARKQQSSRKKairMIIIVLLAFlVSFMPyhiqrtihLH 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 106067657 587 FFAISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQR 632
Cdd:cd15158  238 FLSRKDSTCEEVLYMQKSVVITLCLAAANCCFDPLLYFFSGENFRR 283
LRR_8 pfam13855
Leucine rich repeat;
85-130 8.21e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.19  E-value: 8.21e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 106067657   85 SLERIEANAFDNLLNLSEI-LIQNtkNLRYIEPGAFINLPRLKYLSI 130
Cdd:pfam13855  12 RLTSLDDGAFKGLSNLKVLdLSNN--LLTTLSPGAFSGLPSLRYLDL 56
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
368-634 8.82e-03

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 38.66  E-value: 8.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 368 LINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVdsqtkgqyYNHAIDWQTGSG-CSTAGFFT 446
Cdd:cd15396    9 VVTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDVLVCVMCIPFTAV--------YTLMDHWIFGETmCKLTSFVQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 447 VFASELSVYTLTVITLERWHTITYAihLDQKLRLRHAILIMLGGWLFSSLIAML----------PLVGVSN----YMKVS 512
Cdd:cd15396   81 SVSVSVSIFSLVLIAIERYQLIVNP--RGWKPSASHAYWGIVLIWLFSLMISIPflifhqltdePFRNLSShsdfYKDKV 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 106067657 513 ICFPMDVETTLSQVYILTILILN-VVAFFIICACYIKIYFAVRNPELMA---------TNKDTKIAKKMAILIFTDFTCM 582
Cdd:cd15396  159 VCIEAWPSETERLIFTTSLLVFQyFVPLGFIFICYLKIFVCLKKRNSKIdrmrenesrLSENKRINTMLISIVVTFAACW 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 106067657 583 APISFFAISAAFKVPLITVTNSKVLLVLFY---PINSCANPFLYAIFTKTFQRDF 634
Cdd:cd15396  239 LPLNIFNVVFDWNHEVLMSCHHNLVFTLCHlvaMVSTCINPIFYGFLNKNFQKDL 293
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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