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Conserved domains on  [gi|47078292|ref|NP_000203|]
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integrin beta-3 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
INB smart00187
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins ...
 38-461 0e+00

Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed).


:

Pssm-ID: 197563 [Multi-domain]  Cd Length: 423  Bit Score: 708.32  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078292     38 SCQQCLAVSPMCAWCSDEALPLG-SPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGDssQVTQVSPQRIAL 116
Cdd:smart00187   1 SCEECIQSGPNCAWCTDENFTSGgSARCDTRANLLAKGCSPESIENPASSAEVLEDKPLSDKGSGG--QAVQVSPQRVRL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078292    117 RLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPp 196
Cdd:smart00187  79 KLRPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHP- 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078292    197 EALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTT 276
Cdd:smart00187 158 EKLENPCPNYNKTCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARRLLVFST 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078292    277 DAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTV 356
Cdd:smart00187 238 DAGFHFAGDGKLGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSV 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078292    357 GVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGCPQEK 436
Cdd:smart00187 318 GELSEDSSNVVELIKDAYNKISSRVELEDNALPEGVSVTYTSSCPGGVTGPGTRKCEGVKIGDTVSFEVTVTATKCPPED 397

                          410       420
                   ....*....|....*....|....*.
gi 47078292    437 -EKSFTIKPVGFKDSLIVQVTFDCDC 461
Cdd:smart00187 398 qEQSIRIRPVGFSETLEVEVTFLCDC 423
Integrin_B_tail pfam07965
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ...
 634-717 3.95e-28

Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.


:

Pssm-ID: 462325  Cd Length: 84  Bit Score: 108.13  E-value: 3.95e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078292   634 CTFKKECVECKKFDRGALhDENTCNRYCRDEIESVKELKDTG-KDAVNCTYKNEDDCVVRFQYYEDSSGKSILYVVEEPE 712
Cdd:pfam07965   1 CEEKKSCVECQAFKTGPL-KEKNCSRNCKFEIILVEVLKEDEePGAVLCSFKDEDDCWFTFTYYEDESGKYVVHVQKERE 79


                  ....*
gi 47078292   713 CPKGP 717
Cdd:pfam07965  80 CPPGP 84
Integrin_b_cyt pfam08725
Integrin beta cytoplasmic domain; Integrins are a group of transmembrane proteins which ...
 745-785 7.45e-19

Integrin beta cytoplasmic domain; Integrins are a group of transmembrane proteins which function as extracellular matrix receptors and in cell adhesion. Integrins are ubiquitously expressed and are heterodimeric, each composed of an alpha and beta subunit. Several variations of the the alpha and beta subunits exist, and association of different alpha and beta subunits can have different a different binding specificity. This domain corresponds to the cytoplasmic domain of the beta subunit.


:

Pssm-ID: 462580  Cd Length: 41  Bit Score: 80.30  E-value: 7.45e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 47078292   745 ITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITY 785
Cdd:pfam08725   1 TTIHDRREYAKFEKERKNAKWTTGENPLYKSATTTFENPTY 41
I-EGF_1 pfam18372
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ...
 463-492 1.09e-09

Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.


:

Pssm-ID: 465729  Cd Length: 29  Bit Score: 54.03  E-value: 1.09e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 47078292   463 CQAQAEPNSHRCNnGNGTFECGVCRCGPGW 492
Cdd:pfam18372   1 CEKQAEPNSPRCS-GNGTFVCGVCVCNPGY 29
VESA1_N super family cl20469
Variant erythrocyte surface antigen-1; This family represents the N-terminal of the variant ...
 549-660 9.64e-03

Variant erythrocyte surface antigen-1; This family represents the N-terminal of the variant erythrocyte surface antigen 1, versions a and b, of Babesia. Babesia bovis is a tick-borne, intra-erythrocytic, protozoal parasite of cattle that shares many lifestyle parallels with the most virulent of the human malarial parasites, Plasmodium falciparum. Babesia uses antigenic variation to establish consistent infections of long duration. The two variants of VESA1, a and b, are expressed from different but closely related genes, and variation is achieved through the involvement of a segmental gene conversion mechanism and low-frequency epigenetic in situ switching of transcriptional activity from the VESA1 gene-pair to a possible other gene pair.


The actual alignment was detected with superfamily member pfam12785:

Pssm-ID: 463704  Cd Length: 461  Bit Score: 39.18  E-value: 9.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078292   549 CDDFSCVRYKGEMCS---GHgQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLCSGRGKCECgsCVCiqpgsyGDTCE 625
Cdd:pfam12785 111 CNECGCMKWRVTRCSddkGH-PLGRGCTRCSSSGAEETCKCSLGGKCCCSYCKCKCAKAGKCCK--CCC------KDDCG 181

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 47078292   626 KCptcpdactFKKECVECKKFDRGALHDENTCNRY 660
Cdd:pfam12785 182 GC--------KKGKCSCYKEIYQSAEMLFPSIDSY 208
 
Name Accession Description Interval E-value
INB smart00187
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins ...
 38-461 0e+00

Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed).


Pssm-ID: 197563 [Multi-domain]  Cd Length: 423  Bit Score: 708.32  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078292     38 SCQQCLAVSPMCAWCSDEALPLG-SPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGDssQVTQVSPQRIAL 116
Cdd:smart00187   1 SCEECIQSGPNCAWCTDENFTSGgSARCDTRANLLAKGCSPESIENPASSAEVLEDKPLSDKGSGG--QAVQVSPQRVRL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078292    117 RLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPp 196
Cdd:smart00187  79 KLRPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHP- 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078292    197 EALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTT 276
Cdd:smart00187 158 EKLENPCPNYNKTCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARRLLVFST 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078292    277 DAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTV 356
Cdd:smart00187 238 DAGFHFAGDGKLGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSV 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078292    357 GVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGCPQEK 436
Cdd:smart00187 318 GELSEDSSNVVELIKDAYNKISSRVELEDNALPEGVSVTYTSSCPGGVTGPGTRKCEGVKIGDTVSFEVTVTATKCPPED 397

                          410       420
                   ....*....|....*....|....*.
gi 47078292    437 -EKSFTIKPVGFKDSLIVQVTFDCDC 461
Cdd:smart00187 398 qEQSIRIRPVGFSETLEVEVTFLCDC 423
Integrin_beta pfam00362
Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have ...
 133-381 6.78e-168

Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have also been found in cyanobacteria, probably due to horizontal gene transfer. This domain corresponds to the integrin beta VWA domain.


Pssm-ID: 459781  Cd Length: 248  Bit Score: 484.31  E-value: 6.78e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078292   133 VEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPpEALENPCYDMKTTCLP 212
Cdd:pfam00362   1 AEDYPVDLYYLMDLSYSMKDDLDNLKKLGNDLAEEMRNITSNFRLGFGSFVDKPVMPYISTRP-EKLKNPCPGENEQCDP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078292   213 MFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIV 292
Cdd:pfam00362  80 PFGFRHVLSLTNDIEEFTEEVQKQRISGNLDAPEGGFDAIMQAAVCKDQIGWRNEARRLLVFSTDAGFHYAGDGKLAGIV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078292   293 QPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVD 372
Cdd:pfam00362 160 TPNDGQCHLDSNGEYTKSTEQDYPSLGQLVRKLSENNINPIFAVTEEQYSLYEKLSKLIPGSSVGVLSEDSSNIVQLIKE 239


                  ....*....
gi 47078292   373 AYGKIRSKV 381
Cdd:pfam00362 240 AYEKIRSKV 248
Integrin_B_tail pfam07965
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ...
 634-717 3.95e-28

Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.


Pssm-ID: 462325  Cd Length: 84  Bit Score: 108.13  E-value: 3.95e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078292   634 CTFKKECVECKKFDRGALhDENTCNRYCRDEIESVKELKDTG-KDAVNCTYKNEDDCVVRFQYYEDSSGKSILYVVEEPE 712
Cdd:pfam07965   1 CEEKKSCVECQAFKTGPL-KEKNCSRNCKFEIILVEVLKEDEePGAVLCSFKDEDDCWFTFTYYEDESGKYVVHVQKERE 79


                  ....*
gi 47078292   713 CPKGP 717
Cdd:pfam07965  80 CPPGP 84
Integrin_b_cyt pfam08725
Integrin beta cytoplasmic domain; Integrins are a group of transmembrane proteins which ...
 745-785 7.45e-19

Integrin beta cytoplasmic domain; Integrins are a group of transmembrane proteins which function as extracellular matrix receptors and in cell adhesion. Integrins are ubiquitously expressed and are heterodimeric, each composed of an alpha and beta subunit. Several variations of the the alpha and beta subunits exist, and association of different alpha and beta subunits can have different a different binding specificity. This domain corresponds to the cytoplasmic domain of the beta subunit.


Pssm-ID: 462580  Cd Length: 41  Bit Score: 80.30  E-value: 7.45e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 47078292   745 ITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITY 785
Cdd:pfam08725   1 TTIHDRREYAKFEKERKNAKWTTGENPLYKSATTTFENPTY 41
I-EGF_1 pfam18372
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ...
 463-492 1.09e-09

Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.


Pssm-ID: 465729  Cd Length: 29  Bit Score: 54.03  E-value: 1.09e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 47078292   463 CQAQAEPNSHRCNnGNGTFECGVCRCGPGW 492
Cdd:pfam18372   1 CEKQAEPNSPRCS-GNGTFVCGVCVCNPGY 29
VESA1_N pfam12785
Variant erythrocyte surface antigen-1; This family represents the N-terminal of the variant ...
 549-660 9.64e-03

Variant erythrocyte surface antigen-1; This family represents the N-terminal of the variant erythrocyte surface antigen 1, versions a and b, of Babesia. Babesia bovis is a tick-borne, intra-erythrocytic, protozoal parasite of cattle that shares many lifestyle parallels with the most virulent of the human malarial parasites, Plasmodium falciparum. Babesia uses antigenic variation to establish consistent infections of long duration. The two variants of VESA1, a and b, are expressed from different but closely related genes, and variation is achieved through the involvement of a segmental gene conversion mechanism and low-frequency epigenetic in situ switching of transcriptional activity from the VESA1 gene-pair to a possible other gene pair.


Pssm-ID: 463704  Cd Length: 461  Bit Score: 39.18  E-value: 9.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078292   549 CDDFSCVRYKGEMCS---GHgQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLCSGRGKCECgsCVCiqpgsyGDTCE 625
Cdd:pfam12785 111 CNECGCMKWRVTRCSddkGH-PLGRGCTRCSSSGAEETCKCSLGGKCCCSYCKCKCAKAGKCCK--CCC------KDDCG 181

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 47078292   626 KCptcpdactFKKECVECKKFDRGALHDENTCNRY 660
Cdd:pfam12785 182 GC--------KKGKCSCYKEIYQSAEMLFPSIDSY 208
 
Name Accession Description Interval E-value
INB smart00187
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins ...
 38-461 0e+00

Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed).


Pssm-ID: 197563 [Multi-domain]  Cd Length: 423  Bit Score: 708.32  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078292     38 SCQQCLAVSPMCAWCSDEALPLG-SPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGDssQVTQVSPQRIAL 116
Cdd:smart00187   1 SCEECIQSGPNCAWCTDENFTSGgSARCDTRANLLAKGCSPESIENPASSAEVLEDKPLSDKGSGG--QAVQVSPQRVRL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078292    117 RLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPp 196
Cdd:smart00187  79 KLRPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHP- 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078292    197 EALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTT 276
Cdd:smart00187 158 EKLENPCPNYNKTCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARRLLVFST 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078292    277 DAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTV 356
Cdd:smart00187 238 DAGFHFAGDGKLGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSV 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078292    357 GVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGCPQEK 436
Cdd:smart00187 318 GELSEDSSNVVELIKDAYNKISSRVELEDNALPEGVSVTYTSSCPGGVTGPGTRKCEGVKIGDTVSFEVTVTATKCPPED 397

                          410       420
                   ....*....|....*....|....*.
gi 47078292    437 -EKSFTIKPVGFKDSLIVQVTFDCDC 461
Cdd:smart00187 398 qEQSIRIRPVGFSETLEVEVTFLCDC 423
Integrin_beta pfam00362
Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have ...
 133-381 6.78e-168

Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have also been found in cyanobacteria, probably due to horizontal gene transfer. This domain corresponds to the integrin beta VWA domain.


Pssm-ID: 459781  Cd Length: 248  Bit Score: 484.31  E-value: 6.78e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078292   133 VEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPpEALENPCYDMKTTCLP 212
Cdd:pfam00362   1 AEDYPVDLYYLMDLSYSMKDDLDNLKKLGNDLAEEMRNITSNFRLGFGSFVDKPVMPYISTRP-EKLKNPCPGENEQCDP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078292   213 MFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIV 292
Cdd:pfam00362  80 PFGFRHVLSLTNDIEEFTEEVQKQRISGNLDAPEGGFDAIMQAAVCKDQIGWRNEARRLLVFSTDAGFHYAGDGKLAGIV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078292   293 QPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVD 372
Cdd:pfam00362 160 TPNDGQCHLDSNGEYTKSTEQDYPSLGQLVRKLSENNINPIFAVTEEQYSLYEKLSKLIPGSSVGVLSEDSSNIVQLIKE 239


                  ....*....
gi 47078292   373 AYGKIRSKV 381
Cdd:pfam00362 240 AYEKIRSKV 248
Integrin_B_tail pfam07965
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ...
 634-717 3.95e-28

Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.


Pssm-ID: 462325  Cd Length: 84  Bit Score: 108.13  E-value: 3.95e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078292   634 CTFKKECVECKKFDRGALhDENTCNRYCRDEIESVKELKDTG-KDAVNCTYKNEDDCVVRFQYYEDSSGKSILYVVEEPE 712
Cdd:pfam07965   1 CEEKKSCVECQAFKTGPL-KEKNCSRNCKFEIILVEVLKEDEePGAVLCSFKDEDDCWFTFTYYEDESGKYVVHVQKERE 79


                  ....*
gi 47078292   713 CPKGP 717
Cdd:pfam07965  80 CPPGP 84
Integrin_b_cyt pfam08725
Integrin beta cytoplasmic domain; Integrins are a group of transmembrane proteins which ...
 745-785 7.45e-19

Integrin beta cytoplasmic domain; Integrins are a group of transmembrane proteins which function as extracellular matrix receptors and in cell adhesion. Integrins are ubiquitously expressed and are heterodimeric, each composed of an alpha and beta subunit. Several variations of the the alpha and beta subunits exist, and association of different alpha and beta subunits can have different a different binding specificity. This domain corresponds to the cytoplasmic domain of the beta subunit.


Pssm-ID: 462580  Cd Length: 41  Bit Score: 80.30  E-value: 7.45e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 47078292   745 ITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITY 785
Cdd:pfam08725   1 TTIHDRREYAKFEKERKNAKWTTGENPLYKSATTTFENPTY 41
PSI_integrin pfam17205
Integrin plexin domain; This short disulphide rich domain is found at the N-terminus of ...
 29-75 1.51e-10

Integrin plexin domain; This short disulphide rich domain is found at the N-terminus of integrin beta chains.


Pssm-ID: 465380  Cd Length: 47  Bit Score: 56.79  E-value: 1.51e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 47078292    29 NICTTRGvSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNC 75
Cdd:pfam17205   1 NRCTSAS-TSCEECIQSGPDCAWCTDENFTSGSPRCDTRENLLARGC 46
I-EGF_1 pfam18372
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ...
 463-492 1.09e-09

Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.


Pssm-ID: 465729  Cd Length: 29  Bit Score: 54.03  E-value: 1.09e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 47078292   463 CQAQAEPNSHRCNnGNGTFECGVCRCGPGW 492
Cdd:pfam18372   1 CEKQAEPNSPRCS-GNGTFVCGVCVCNPGY 29
VESA1_N pfam12785
Variant erythrocyte surface antigen-1; This family represents the N-terminal of the variant ...
 549-660 9.64e-03

Variant erythrocyte surface antigen-1; This family represents the N-terminal of the variant erythrocyte surface antigen 1, versions a and b, of Babesia. Babesia bovis is a tick-borne, intra-erythrocytic, protozoal parasite of cattle that shares many lifestyle parallels with the most virulent of the human malarial parasites, Plasmodium falciparum. Babesia uses antigenic variation to establish consistent infections of long duration. The two variants of VESA1, a and b, are expressed from different but closely related genes, and variation is achieved through the involvement of a segmental gene conversion mechanism and low-frequency epigenetic in situ switching of transcriptional activity from the VESA1 gene-pair to a possible other gene pair.


Pssm-ID: 463704  Cd Length: 461  Bit Score: 39.18  E-value: 9.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078292   549 CDDFSCVRYKGEMCS---GHgQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLCSGRGKCECgsCVCiqpgsyGDTCE 625
Cdd:pfam12785 111 CNECGCMKWRVTRCSddkGH-PLGRGCTRCSSSGAEETCKCSLGGKCCCSYCKCKCAKAGKCCK--CCC------KDDCG 181

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 47078292   626 KCptcpdactFKKECVECKKFDRGALHDENTCNRY 660
Cdd:pfam12785 182 GC--------KKGKCSCYKEIYQSAEMLFPSIDSY 208
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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