NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|83281450|ref|NP_000144|]
View 

galactocerebrosidase isoform a precursor [Homo sapiens]

Protein Classification

galactocerebrosidase( domain architecture ID 13670604)

galactocerebrosidase hydrolyzes the galactose ester bonds of glycolipids such as galactosylceramide and galactosylsphingosine

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Glyco_hydro_59 pfam02057
Glycosyl hydrolase family 59;
55-349 1.93e-146

Glycosyl hydrolase family 59;


:

Pssm-ID: 396577  Cd Length: 293  Bit Score: 427.52  E-value: 1.93e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83281450    55 FDGIGAVSGGgATSRLLVNYPEPYRSQILDYLFKPNFGASLHILKVEIGGDGQTTDGTEPSHMHYALDE-NYFRGYEWWL 133
Cdd:pfam02057   1 FDGIGAISAG-ATSRLLLDYPEPQRSQILDYLFKPNFGASLQHLKVEIGGDANSSSGTEPSHMRTRDELaDVNRGYEWWL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83281450   134 MKEAKKRNPNITLIGLPWSFPGWLGkgfDWPYVNLQLTAYYVVTWIVGAKRYHDLDIDYI-GIWNERSYNANYIKILRKM 212
Cdd:pfam02057  80 MAEAKKRNPDIKLDGLPWGAPGWVG---GGPGFWSEDTYDYLKSWIDGAKRTYGLDIDYIsGLWNERGYDATYVKTLRPA 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83281450   213 LNYQGLQRVKIIASDNLWE-SISASMLLDAELFKVVDVIGAHYPGTHSAKD--AKLTGKKLWSSEDFSTLNsdmGAGCWG 289
Cdd:pfam02057 157 LDAYGYKKIKIVASDEAGTwSIADDMLKDPELRDAVDVIGYHYPSTDSSYSnlALATGKPLWASEDLSSLN---SALDIA 233
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 83281450   290 RILNQNYINGYMTSTIAWNLVASYYEQLPYGRCGLMTAQEPWSGHYVVESPVWVSAHTTQ 349
Cdd:pfam02057 234 RRINRNYVNGRMTSYIFWPLIAAYYPGAPYSGKGLMTANEPWSGYYEVDPGIWATAHTTQ 293
Glyco_hydro_59M pfam17387
Glycosyl hydrolase family 59 central domain;
357-464 3.11e-58

Glycosyl hydrolase family 59 central domain;


:

Pssm-ID: 465411  Cd Length: 116  Bit Score: 192.03  E-value: 3.11e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83281450   357 YLKTVGHLEKGGSYVALTDGLGNLTIIIETMSHKHSKCIRPFLPYFNVSQQFATFVLKGSFSEIPELQVWYTKLG-KTSE 435
Cdd:pfam17387   1 YLKGVGHLEQGGSYVALTDGLGNLTIIIETMSHNHSQCIRPPLPPYNVSPQNATFRLKGSFANITKLQVWYSKLGfKSNK 80
                          90       100
                  ....*....|....*....|....*....
gi 83281450   436 RFLFKQLDSlwLLDSDGSFTLSLHEDELF 464
Cdd:pfam17387  81 SVLFKKLGP--IKVNNGSFSLKLDVDEVY 107
 
Name Accession Description Interval E-value
Glyco_hydro_59 pfam02057
Glycosyl hydrolase family 59;
55-349 1.93e-146

Glycosyl hydrolase family 59;


Pssm-ID: 396577  Cd Length: 293  Bit Score: 427.52  E-value: 1.93e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83281450    55 FDGIGAVSGGgATSRLLVNYPEPYRSQILDYLFKPNFGASLHILKVEIGGDGQTTDGTEPSHMHYALDE-NYFRGYEWWL 133
Cdd:pfam02057   1 FDGIGAISAG-ATSRLLLDYPEPQRSQILDYLFKPNFGASLQHLKVEIGGDANSSSGTEPSHMRTRDELaDVNRGYEWWL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83281450   134 MKEAKKRNPNITLIGLPWSFPGWLGkgfDWPYVNLQLTAYYVVTWIVGAKRYHDLDIDYI-GIWNERSYNANYIKILRKM 212
Cdd:pfam02057  80 MAEAKKRNPDIKLDGLPWGAPGWVG---GGPGFWSEDTYDYLKSWIDGAKRTYGLDIDYIsGLWNERGYDATYVKTLRPA 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83281450   213 LNYQGLQRVKIIASDNLWE-SISASMLLDAELFKVVDVIGAHYPGTHSAKD--AKLTGKKLWSSEDFSTLNsdmGAGCWG 289
Cdd:pfam02057 157 LDAYGYKKIKIVASDEAGTwSIADDMLKDPELRDAVDVIGYHYPSTDSSYSnlALATGKPLWASEDLSSLN---SALDIA 233
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 83281450   290 RILNQNYINGYMTSTIAWNLVASYYEQLPYGRCGLMTAQEPWSGHYVVESPVWVSAHTTQ 349
Cdd:pfam02057 234 RRINRNYVNGRMTSYIFWPLIAAYYPGAPYSGKGLMTANEPWSGYYEVDPGIWATAHTTQ 293
Glyco_hydro_59M pfam17387
Glycosyl hydrolase family 59 central domain;
357-464 3.11e-58

Glycosyl hydrolase family 59 central domain;


Pssm-ID: 465411  Cd Length: 116  Bit Score: 192.03  E-value: 3.11e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83281450   357 YLKTVGHLEKGGSYVALTDGLGNLTIIIETMSHKHSKCIRPFLPYFNVSQQFATFVLKGSFSEIPELQVWYTKLG-KTSE 435
Cdd:pfam17387   1 YLKGVGHLEQGGSYVALTDGLGNLTIIIETMSHNHSQCIRPPLPPYNVSPQNATFRLKGSFANITKLQVWYSKLGfKSNK 80
                          90       100
                  ....*....|....*....|....*....
gi 83281450   436 RFLFKQLDSlwLLDSDGSFTLSLHEDELF 464
Cdd:pfam17387  81 SVLFKKLGP--IKVNNGSFSLKLDVDEVY 107
XynC COG5520
O-Glycosyl hydrolase [Cell wall/membrane/envelope biogenesis];
54-354 8.10e-17

O-Glycosyl hydrolase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 444271 [Multi-domain]  Cd Length: 445  Bit Score: 83.35  E-value: 8.10e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83281450  54 EFDGIGAvSGGGATSRLLVNYPEPYRSQILDYLFKPNFGASLHILKVEIGG--------------DGQTTDGtepshmHY 119
Cdd:COG5520  50 TIDGFGA-SFTESSAELLGKLSAAKRNELLKELFSPEKGIGLSLLRTPIGAsdfslgsysyddvpDGDPDLG------HF 122
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83281450 120 ALDENyfRGYEWWLMKEAKKRNPNITLIGLPWSFPGWLGKGFDWPYVNLQ---LTAY--YVVTWIvgaKRY--HDLDIDY 192
Cdd:COG5520 123 SIARD--KKYLIPFLKEALAINPDLKIMASPWSPPAWMKTNGSMNGGSLKpeyYDAYadYFVKYI---QAYkkEGIPIDA 197
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83281450 193 IGIWNERSYNANY-------------IK-ILRKMLNYQGLqRVKIIASDNLWESIS---ASMLLDAELFKVVDVIGAH-Y 254
Cdd:COG5520 198 LTPQNEPLAPQNWpsclmtaeeqadfIKnYLGPALEKAGL-DTKILAYDHNRDYKPdypITILSDPEAAKYVDGIAFHwY 276
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83281450 255 PGTHSAKD---AKLTGKKLWSSEdFSTLNSDMGAGCWGRILNQ--NYINGYMTSTIAWNLvASYYEQLPY--GRC-GLMT 326
Cdd:COG5520 277 GGDISALSrvhEAFPDKNLYFTE-GCGGGWDGDWDGALHYANLiiGDLRNWAKGWLDWNL-ALDENGGPNhgGYCnGLVT 354
                       330       340
                ....*....|....*....|....*...
gi 83281450 327 AqEPWSGHYVVESPVWVSAHTTQFTQPG 354
Cdd:COG5520 355 I-DTKTGEVTYNPEYYAIGHFSKFVRPG 381
 
Name Accession Description Interval E-value
Glyco_hydro_59 pfam02057
Glycosyl hydrolase family 59;
55-349 1.93e-146

Glycosyl hydrolase family 59;


Pssm-ID: 396577  Cd Length: 293  Bit Score: 427.52  E-value: 1.93e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83281450    55 FDGIGAVSGGgATSRLLVNYPEPYRSQILDYLFKPNFGASLHILKVEIGGDGQTTDGTEPSHMHYALDE-NYFRGYEWWL 133
Cdd:pfam02057   1 FDGIGAISAG-ATSRLLLDYPEPQRSQILDYLFKPNFGASLQHLKVEIGGDANSSSGTEPSHMRTRDELaDVNRGYEWWL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83281450   134 MKEAKKRNPNITLIGLPWSFPGWLGkgfDWPYVNLQLTAYYVVTWIVGAKRYHDLDIDYI-GIWNERSYNANYIKILRKM 212
Cdd:pfam02057  80 MAEAKKRNPDIKLDGLPWGAPGWVG---GGPGFWSEDTYDYLKSWIDGAKRTYGLDIDYIsGLWNERGYDATYVKTLRPA 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83281450   213 LNYQGLQRVKIIASDNLWE-SISASMLLDAELFKVVDVIGAHYPGTHSAKD--AKLTGKKLWSSEDFSTLNsdmGAGCWG 289
Cdd:pfam02057 157 LDAYGYKKIKIVASDEAGTwSIADDMLKDPELRDAVDVIGYHYPSTDSSYSnlALATGKPLWASEDLSSLN---SALDIA 233
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 83281450   290 RILNQNYINGYMTSTIAWNLVASYYEQLPYGRCGLMTAQEPWSGHYVVESPVWVSAHTTQ 349
Cdd:pfam02057 234 RRINRNYVNGRMTSYIFWPLIAAYYPGAPYSGKGLMTANEPWSGYYEVDPGIWATAHTTQ 293
Glyco_hydro_59M pfam17387
Glycosyl hydrolase family 59 central domain;
357-464 3.11e-58

Glycosyl hydrolase family 59 central domain;


Pssm-ID: 465411  Cd Length: 116  Bit Score: 192.03  E-value: 3.11e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83281450   357 YLKTVGHLEKGGSYVALTDGLGNLTIIIETMSHKHSKCIRPFLPYFNVSQQFATFVLKGSFSEIPELQVWYTKLG-KTSE 435
Cdd:pfam17387   1 YLKGVGHLEQGGSYVALTDGLGNLTIIIETMSHNHSQCIRPPLPPYNVSPQNATFRLKGSFANITKLQVWYSKLGfKSNK 80
                          90       100
                  ....*....|....*....|....*....
gi 83281450   436 RFLFKQLDSlwLLDSDGSFTLSLHEDELF 464
Cdd:pfam17387  81 SVLFKKLGP--IKVNNGSFSLKLDVDEVY 107
XynC COG5520
O-Glycosyl hydrolase [Cell wall/membrane/envelope biogenesis];
54-354 8.10e-17

O-Glycosyl hydrolase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 444271 [Multi-domain]  Cd Length: 445  Bit Score: 83.35  E-value: 8.10e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83281450  54 EFDGIGAvSGGGATSRLLVNYPEPYRSQILDYLFKPNFGASLHILKVEIGG--------------DGQTTDGtepshmHY 119
Cdd:COG5520  50 TIDGFGA-SFTESSAELLGKLSAAKRNELLKELFSPEKGIGLSLLRTPIGAsdfslgsysyddvpDGDPDLG------HF 122
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83281450 120 ALDENyfRGYEWWLMKEAKKRNPNITLIGLPWSFPGWLGKGFDWPYVNLQ---LTAY--YVVTWIvgaKRY--HDLDIDY 192
Cdd:COG5520 123 SIARD--KKYLIPFLKEALAINPDLKIMASPWSPPAWMKTNGSMNGGSLKpeyYDAYadYFVKYI---QAYkkEGIPIDA 197
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83281450 193 IGIWNERSYNANY-------------IK-ILRKMLNYQGLqRVKIIASDNLWESIS---ASMLLDAELFKVVDVIGAH-Y 254
Cdd:COG5520 198 LTPQNEPLAPQNWpsclmtaeeqadfIKnYLGPALEKAGL-DTKILAYDHNRDYKPdypITILSDPEAAKYVDGIAFHwY 276
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83281450 255 PGTHSAKD---AKLTGKKLWSSEdFSTLNSDMGAGCWGRILNQ--NYINGYMTSTIAWNLvASYYEQLPY--GRC-GLMT 326
Cdd:COG5520 277 GGDISALSrvhEAFPDKNLYFTE-GCGGGWDGDWDGALHYANLiiGDLRNWAKGWLDWNL-ALDENGGPNhgGYCnGLVT 354
                       330       340
                ....*....|....*....|....*...
gi 83281450 327 AqEPWSGHYVVESPVWVSAHTTQFTQPG 354
Cdd:COG5520 355 I-DTKTGEVTYNPEYYAIGHFSKFVRPG 381
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH