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Conserved domains on  [gi|4503107|ref|NP_000090|]
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cystatin-C precursor [Homo sapiens]

Protein Classification

cystatin family protein( domain architecture ID 11249387)

cystatin family protein similar to cystatins which are a family of cysteine protease inhibitors

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 34-144 1.09e-41

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


:

Pssm-ID: 214484  Cd Length: 107  Bit Score: 134.48  E-value: 1.09e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503107      34 RLVGGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHD 113
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSVDLENCPFLD 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 4503107     114 QPhlkrKAFCSFQIYAVPWQGTMTLSKSTCQ 144
Cdd:smart00043  81 QG----EKFCTAKVWEKPWENKIKLVEFKCT 107
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 34-144 1.09e-41

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 134.48  E-value: 1.09e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503107      34 RLVGGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHD 113
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSVDLENCPFLD 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 4503107     114 QPhlkrKAFCSFQIYAVPWQGTMTLSKSTCQ 144
Cdd:smart00043  81 QG----EKFCTAKVWEKPWENKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 37-143 1.77e-36

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 121.04  E-value: 1.77e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503107   37 GGPMDASVEEEGVRRALDFAVGEYNKASNDMYhSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDnCPFHDQPH 116
Cdd:cd00042   1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKY-LEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLD-CPDCKLLE 78

                        90       100
                ....*....|....*....|....*..
gi 4503107  117 LKRKAFCSFQIYAVPWQGTMTLSKSTC 143
Cdd:cd00042  79 EGKKKFCTAKVWEKPWENFKELLSFKC 105
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 37-132 2.83e-35

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 117.44  E-value: 2.83e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503107     37 GGPMDASVEEEGVRRALDFAVGEYNKASNDmYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQph 116
Cdd:pfam00031   1 GGLSPIPDNSPELQEALDFALAEYNAKTDN-YYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSKSKKLLEDCPLLDE-- 77

                          90
                  ....*....|....*.
gi 4503107    117 lKRKAFCSFQIYAVPW 132
Cdd:pfam00031  78 -KWLGLCSAQVYKVPW 92
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 34-144 1.09e-41

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 134.48  E-value: 1.09e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503107      34 RLVGGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHD 113
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSVDLENCPFLD 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 4503107     114 QPhlkrKAFCSFQIYAVPWQGTMTLSKSTCQ 144
Cdd:smart00043  81 QG----EKFCTAKVWEKPWENKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 37-143 1.77e-36

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 121.04  E-value: 1.77e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503107   37 GGPMDASVEEEGVRRALDFAVGEYNKASNDMYhSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDnCPFHDQPH 116
Cdd:cd00042   1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKY-LEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLD-CPDCKLLE 78

                        90       100
                ....*....|....*....|....*..
gi 4503107  117 LKRKAFCSFQIYAVPWQGTMTLSKSTC 143
Cdd:cd00042  79 EGKKKFCTAKVWEKPWENFKELLSFKC 105
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 37-132 2.83e-35

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 117.44  E-value: 2.83e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503107     37 GGPMDASVEEEGVRRALDFAVGEYNKASNDmYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQph 116
Cdd:pfam00031   1 GGLSPIPDNSPELQEALDFALAEYNAKTDN-YYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSKSKKLLEDCPLLDE-- 77

                          90
                  ....*....|....*.
gi 4503107    117 lKRKAFCSFQIYAVPW 132
Cdd:pfam00031  78 -KWLGLCSAQVYKVPW 92
SQAPI pfam16845
Aspartic acid proteinase inhibitor; SQAPI, aspartic acid inhibitor first isolated from squash, ...
 44-90 3.26e-03

Aspartic acid proteinase inhibitor; SQAPI, aspartic acid inhibitor first isolated from squash, inhibits a wide range of aspartic proteinases. This particular family of PAAPIs (proteinaceous aspartic acid inhibitors) seems to have evolved quite recently from an ancestral cystatin. Structurally it consists of a four-stranded anti-parallel beta-sheet gripping an alpha-helix in much the same manner that a hand grips a tennis racket. The unstructured N-terminus and the loop connecting beta-strands 1 and 2 are important for pepsin inhibition, but the loop connecting strands 3 and 4 is not.


Pssm-ID: 407092  Cd Length: 83  Bit Score: 34.71  E-value: 3.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 4503107     44 VEEEGVRRALDFAVGEYNKASNDmyhSRALQ-VVRARKQIVAGVNYFL 90
Cdd:pfam16845   4 VSDPHVVEIAKFAVSEHNKQSKA---NLVFVkVVKGETQVVSGTNYRL 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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