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Conserved domains on  [gi|110349767|ref|NP_000060|]
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voltage-dependent L-type calcium channel subunit alpha-1S [Homo sapiens]

Protein Classification

voltage-dependent calcium channel subunit alpha-1( domain architecture ID 11999358)

voltage-dependent calcium channel subunit alpha-1 is part of a multisubunit voltage-dependent calcium channel that mediates the entry of calcium ions into excitable cells and is also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1117-1392 2.65e-65

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 221.76  E-value: 2.65e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767  1117 SSYFEYLMFALIMLNTICLGMQHYNQSEQ-MNHISDILNVAFTIIFTLEMILKLMAFK-ARGYFGDPWNVFDFLIVIGSI 1194
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGfKKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767  1195 IDVILSEIDTFLASSgglyclgggcgnvdpdesarissaFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLI 1274
Cdd:pfam00520   81 ISLVLSSVGSLSGLR------------------------VLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLL 136
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767  1275 VMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKlcdpesdyapgeeytcGT 1354
Cdd:pfam00520  137 LLFLFIFAIIGYQLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK----------------GE 200
                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 110349767  1355 NFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWS 1392
Cdd:pfam00520  201 FWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
50-345 2.62e-60

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 207.50  E-value: 2.62e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767    50 WKPFETIILLTIFANCVALAVYLPMPEDDnnSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHqdaYLRSGWNVLDFTI 129
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEE--PLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767   130 VFLGVFTVIleqvnviqshtapMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVII 209
Cdd:pfam00520   76 VLPSLISLV-------------LSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFI 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767   210 YAIIGLELFKGKMHKtcyfigtdivatveneepspcartgsgrrctingsecrggWPGPNHGITHFDNFGFSMLTVYQCI 289
Cdd:pfam00520  143 FAIIGYQLFGGKLKT----------------------------------------WENPDNGRTNFDNFPNAFLWLFQTM 182
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 110349767   290 TMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAK 345
Cdd:pfam00520  183 TTEGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
431-672 1.67e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 193.64  E-value: 1.67e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767   431 SKVFYWLVILIVALNTLSIASEHHNQPLW-LTRLQDIANRVLLSLFTTEMLMKMYGLGL-RQYFMSIFNRFDCFVVCSGI 508
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767   509 LEILLveSGAMTPLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYD-F 587
Cdd:pfam00520   81 ISLVL--SSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKtW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767   588 EDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGgpsypGMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEA 667
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQEL 233

                   ....*
gi 110349767   668 ESLTS 672
Cdd:pfam00520  234 TERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
798-1075 1.12e-46

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 168.21  E-value: 1.12e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767   798 ATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHkgsFCRNYFNMLDLLVVA 877
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767   878 VSLISMGL-ESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFR 956
Cdd:pfam00520   78 PSLISLVLsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767   957 ctdlskmteeecrgyyyvykdgdpmqielrHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYn 1036
Cdd:pfam00520  158 ------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAYIY- 206
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 110349767  1037 nrvemaifFIIYIILIAFFMMNIFVGFVIVTFQEQGETE 1075
Cdd:pfam00520  207 --------FVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1464-1536 1.29e-34

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


:

Pssm-ID: 462591  Cd Length: 77  Bit Score: 127.32  E-value: 1.29e-34
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 110349767  1464 NATLFALVRTALKIKTE--GNFEQANEELRAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKF 1536
Cdd:pfam08763    1 TATLFALIRTSLKIKLApaGEMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQN 75
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1401-1454 1.24e-29

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


:

Pssm-ID: 465306  Cd Length: 54  Bit Score: 112.36  E-value: 1.24e-29
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 110349767  1401 EFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMP 1454
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1117-1392 2.65e-65

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 221.76  E-value: 2.65e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767  1117 SSYFEYLMFALIMLNTICLGMQHYNQSEQ-MNHISDILNVAFTIIFTLEMILKLMAFK-ARGYFGDPWNVFDFLIVIGSI 1194
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGfKKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767  1195 IDVILSEIDTFLASSgglyclgggcgnvdpdesarissaFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLI 1274
Cdd:pfam00520   81 ISLVLSSVGSLSGLR------------------------VLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLL 136
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767  1275 VMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKlcdpesdyapgeeytcGT 1354
Cdd:pfam00520  137 LLFLFIFAIIGYQLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK----------------GE 200
                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 110349767  1355 NFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWS 1392
Cdd:pfam00520  201 FWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
50-345 2.62e-60

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 207.50  E-value: 2.62e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767    50 WKPFETIILLTIFANCVALAVYLPMPEDDnnSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHqdaYLRSGWNVLDFTI 129
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEE--PLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767   130 VFLGVFTVIleqvnviqshtapMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVII 209
Cdd:pfam00520   76 VLPSLISLV-------------LSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFI 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767   210 YAIIGLELFKGKMHKtcyfigtdivatveneepspcartgsgrrctingsecrggWPGPNHGITHFDNFGFSMLTVYQCI 289
Cdd:pfam00520  143 FAIIGYQLFGGKLKT----------------------------------------WENPDNGRTNFDNFPNAFLWLFQTM 182
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 110349767   290 TMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAK 345
Cdd:pfam00520  183 TTEGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
431-672 1.67e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 193.64  E-value: 1.67e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767   431 SKVFYWLVILIVALNTLSIASEHHNQPLW-LTRLQDIANRVLLSLFTTEMLMKMYGLGL-RQYFMSIFNRFDCFVVCSGI 508
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767   509 LEILLveSGAMTPLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYD-F 587
Cdd:pfam00520   81 ISLVL--SSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKtW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767   588 EDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGgpsypGMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEA 667
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQEL 233

                   ....*
gi 110349767   668 ESLTS 672
Cdd:pfam00520  234 TERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
798-1075 1.12e-46

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 168.21  E-value: 1.12e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767   798 ATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHkgsFCRNYFNMLDLLVVA 877
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767   878 VSLISMGL-ESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFR 956
Cdd:pfam00520   78 PSLISLVLsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767   957 ctdlskmteeecrgyyyvykdgdpmqielrHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYn 1036
Cdd:pfam00520  158 ------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAYIY- 206
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 110349767  1037 nrvemaifFIIYIILIAFFMMNIFVGFVIVTFQEQGETE 1075
Cdd:pfam00520  207 --------FVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1464-1536 1.29e-34

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 462591  Cd Length: 77  Bit Score: 127.32  E-value: 1.29e-34
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 110349767  1464 NATLFALVRTALKIKTE--GNFEQANEELRAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKF 1536
Cdd:pfam08763    1 TATLFALIRTSLKIKLApaGEMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQN 75
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1401-1454 1.24e-29

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 112.36  E-value: 1.24e-29
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 110349767  1401 EFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMP 1454
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
Ca_chan_IQ smart01062
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1516-1542 9.89e-11

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 198130  Cd Length: 31  Bit Score: 58.00  E-value: 9.89e-11
                            10        20
                    ....*....|....*....|....*..
gi 110349767   1516 DEVTVGKFYATFLIQEHFRKFMKRQEE 1542
Cdd:smart01062    1 DELTVGKIYAAMLIQDYFRQFKSRKEQ 27
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1117-1392 2.65e-65

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 221.76  E-value: 2.65e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767  1117 SSYFEYLMFALIMLNTICLGMQHYNQSEQ-MNHISDILNVAFTIIFTLEMILKLMAFK-ARGYFGDPWNVFDFLIVIGSI 1194
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGfKKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767  1195 IDVILSEIDTFLASSgglyclgggcgnvdpdesarissaFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLI 1274
Cdd:pfam00520   81 ISLVLSSVGSLSGLR------------------------VLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLL 136
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767  1275 VMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKlcdpesdyapgeeytcGT 1354
Cdd:pfam00520  137 LLFLFIFAIIGYQLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK----------------GE 200
                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 110349767  1355 NFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWS 1392
Cdd:pfam00520  201 FWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
50-345 2.62e-60

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 207.50  E-value: 2.62e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767    50 WKPFETIILLTIFANCVALAVYLPMPEDDnnSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHqdaYLRSGWNVLDFTI 129
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEE--PLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767   130 VFLGVFTVIleqvnviqshtapMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVII 209
Cdd:pfam00520   76 VLPSLISLV-------------LSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFI 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767   210 YAIIGLELFKGKMHKtcyfigtdivatveneepspcartgsgrrctingsecrggWPGPNHGITHFDNFGFSMLTVYQCI 289
Cdd:pfam00520  143 FAIIGYQLFGGKLKT----------------------------------------WENPDNGRTNFDNFPNAFLWLFQTM 182
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 110349767   290 TMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAK 345
Cdd:pfam00520  183 TTEGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
431-672 1.67e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 193.64  E-value: 1.67e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767   431 SKVFYWLVILIVALNTLSIASEHHNQPLW-LTRLQDIANRVLLSLFTTEMLMKMYGLGL-RQYFMSIFNRFDCFVVCSGI 508
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767   509 LEILLveSGAMTPLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYD-F 587
Cdd:pfam00520   81 ISLVL--SSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKtW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767   588 EDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGgpsypGMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEA 667
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQEL 233

                   ....*
gi 110349767   668 ESLTS 672
Cdd:pfam00520  234 TERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
798-1075 1.12e-46

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 168.21  E-value: 1.12e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767   798 ATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHkgsFCRNYFNMLDLLVVA 877
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767   878 VSLISMGL-ESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFR 956
Cdd:pfam00520   78 PSLISLVLsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767   957 ctdlskmteeecrgyyyvykdgdpmqielrHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYn 1036
Cdd:pfam00520  158 ------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAYIY- 206
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 110349767  1037 nrvemaifFIIYIILIAFFMMNIFVGFVIVTFQEQGETE 1075
Cdd:pfam00520  207 --------FVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1464-1536 1.29e-34

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 462591  Cd Length: 77  Bit Score: 127.32  E-value: 1.29e-34
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 110349767  1464 NATLFALVRTALKIKTE--GNFEQANEELRAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKF 1536
Cdd:pfam08763    1 TATLFALIRTSLKIKLApaGEMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQN 75
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1401-1454 1.24e-29

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 112.36  E-value: 1.24e-29
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 110349767  1401 EFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMP 1454
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
Ca_chan_IQ smart01062
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1516-1542 9.89e-11

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 198130  Cd Length: 31  Bit Score: 58.00  E-value: 9.89e-11
                            10        20
                    ....*....|....*....|....*..
gi 110349767   1516 DEVTVGKFYATFLIQEHFRKFMKRQEE 1542
Cdd:smart01062    1 DELTVGKIYAAMLIQDYFRQFKSRKEQ 27
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
1152-1385 8.66e-10

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 60.75  E-value: 8.66e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767  1152 ILNVAFTIIFTLEMILKLMAFKARgYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESA--- 1228
Cdd:pfam08016   15 IVFVVFFLYFVVEEILKIRKHRPS-YLRSVWNLLDLAIVILSVVLIVLNIYRDFLADRLIKSVEASPVTFIDFDRVAqld 93
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767  1229 ---RISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGkialvdgtqiNRNNN 1305
Cdd:pfam08016   94 nlyRIILAFLVFLTWLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFG----------TQAPN 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349767  1306 FQTFPQAVLLLFRcatgeawqeillacsygKLCDPESDYapgEEYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFD 1385
Cdd:pfam08016  164 FSNFVKSILTLFR-----------------TILGDFGYN---EIFSGNRVLGPLLFLTFVFLVIFILLNLFLAIINDSYV 223
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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