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Conserved domains on  [gi|9998948|ref|NP_064718|]
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acid-sensing ion channel 3 isoform c [Homo sapiens]

Protein Classification

amiloride-sensitive sodium channel family protein( domain architecture ID 235)

amiloride-sensitive sodium channel family protein such as vertebrate acid-sensing ion channels which are cation channels with high affinity for sodium; may be partial

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ENaC super family cl47122
sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC ...
20-523 1.70e-180

sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the vertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00859:

Pssm-ID: 273304 [Multi-domain]  Cd Length: 595  Bit Score: 520.83  E-value: 1.70e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948     20 FASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALDeRESHRLIFPAVTLCNINPLRR 99
Cdd:TIGR00859   9 FCNNTTTHGAIRIVCSRGGRLKRALWALLTLLALALLLWQCGLLVRYYLSYPVSVSLS-VNSDKLTFPAVTLCNLNPYRY 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948    100 S----RLTPNDLHWAGSALLGLDPAE------------------------------------------------------ 121
Cdd:TIGR00859  88 SkvkhLLEELDLETAQTLLSLYGYNSslarsarsnnrnriplvvldetlprhpvprdlftrqvhnklisnrsnspqvnas 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948    122 -----------------HAAFLRALGRPPAPPGFMPSPTFD--MAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIFT- 181
Cdd:TIGR00859 168 dwkvgfklcnnngsdcfYRTYTSGVQAVREWYRFHYINIFAqvPAEDKDRMGYQLEDFILTCRFDGESCDARNFTHFHHp 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948    182 RMGKCYTFNSGADgAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDneetpfEVGIRVQIHSQEEPPIIDQLGLGVSPGY 261
Cdd:TIGR00859 248 MYGNCYTFNSGEN-SNLLTSSMPGAENGLKLVLDIEQDEYLPLLST------EAGARVMVHSQDEPPFIDDLGFGVRPGT 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948    262 QTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPepsdplgspspSPSPPYTLMGCRLACETRYVARKCGCRMVYMP--GDV 339
Cdd:TIGR00859 321 ETSISMQEDELQRLGGPYGDCTENGSDVPVEN-----------LYNSSYSIQACLRSCFQRYMVENCGCAYYHYPlpGGA 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948    340 PVCSPQQYKNCAHPAIDAMLRKDS------CACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAY----IAENVL 409
Cdd:TIGR00859 390 EYCNYEQHPDWAYCYYKLYAEFDQeelgcfSVCREPCNFTEYKLTLSMARWPSAASEDWLLHVLSRQNEYnitlIRNGIA 469
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948    410 ALDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWN--RQHSQRHSSTNLT 487
Cdd:TIGR00859 470 KLNIFFEELNYRTIEESPAYNVVTLLSNLGGQMGLWMGASVLCVLELLELIIDLIFITLLRLLWRfrKWWQRRRGPPYAE 549
                         570       580       590
                  ....*....|....*....|....*....|....*.
gi 9998948    488 SHPSLCRHQDSLRLPPHLLPCHTALDLLSVSSEPRP 523
Cdd:TIGR00859 550 PPEPVSADTPPSLQLDDPPTFPSALPLPHASGLSLP 585
 
Name Accession Description Interval E-value
ENaC TIGR00859
sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC ...
20-523 1.70e-180

sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the vertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273304 [Multi-domain]  Cd Length: 595  Bit Score: 520.83  E-value: 1.70e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948     20 FASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALDeRESHRLIFPAVTLCNINPLRR 99
Cdd:TIGR00859   9 FCNNTTTHGAIRIVCSRGGRLKRALWALLTLLALALLLWQCGLLVRYYLSYPVSVSLS-VNSDKLTFPAVTLCNLNPYRY 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948    100 S----RLTPNDLHWAGSALLGLDPAE------------------------------------------------------ 121
Cdd:TIGR00859  88 SkvkhLLEELDLETAQTLLSLYGYNSslarsarsnnrnriplvvldetlprhpvprdlftrqvhnklisnrsnspqvnas 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948    122 -----------------HAAFLRALGRPPAPPGFMPSPTFD--MAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIFT- 181
Cdd:TIGR00859 168 dwkvgfklcnnngsdcfYRTYTSGVQAVREWYRFHYINIFAqvPAEDKDRMGYQLEDFILTCRFDGESCDARNFTHFHHp 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948    182 RMGKCYTFNSGADgAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDneetpfEVGIRVQIHSQEEPPIIDQLGLGVSPGY 261
Cdd:TIGR00859 248 MYGNCYTFNSGEN-SNLLTSSMPGAENGLKLVLDIEQDEYLPLLST------EAGARVMVHSQDEPPFIDDLGFGVRPGT 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948    262 QTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPepsdplgspspSPSPPYTLMGCRLACETRYVARKCGCRMVYMP--GDV 339
Cdd:TIGR00859 321 ETSISMQEDELQRLGGPYGDCTENGSDVPVEN-----------LYNSSYSIQACLRSCFQRYMVENCGCAYYHYPlpGGA 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948    340 PVCSPQQYKNCAHPAIDAMLRKDS------CACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAY----IAENVL 409
Cdd:TIGR00859 390 EYCNYEQHPDWAYCYYKLYAEFDQeelgcfSVCREPCNFTEYKLTLSMARWPSAASEDWLLHVLSRQNEYnitlIRNGIA 469
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948    410 ALDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWN--RQHSQRHSSTNLT 487
Cdd:TIGR00859 470 KLNIFFEELNYRTIEESPAYNVVTLLSNLGGQMGLWMGASVLCVLELLELIIDLIFITLLRLLWRfrKWWQRRRGPPYAE 549
                         570       580       590
                  ....*....|....*....|....*....|....*.
gi 9998948    488 SHPSLCRHQDSLRLPPHLLPCHTALDLLSVSSEPRP 523
Cdd:TIGR00859 550 PPEPVSADTPPSLQLDDPPTFPSALPLPHASGLSLP 585
ASC pfam00858
Amiloride-sensitive sodium channel;
20-459 3.72e-118

Amiloride-sensitive sodium channel;


Pssm-ID: 459966 [Multi-domain]  Cd Length: 439  Bit Score: 356.09  E-value: 3.72e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948     20 FASNCSMHGLGHVFGpGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALDERE-SHRLIFPAVTLCNINPLR 98
Cdd:pfam00858   1 FCENTSIHGVRYIKS-KDGFLRRLFWLLLFLASLIFLIYLISLLFEKYLSYPVITVIEEILyVWNVPFPAVTICNLNPFR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948     99 RSRLTPNDLHWAGSA---------LLGLDPAEHAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQ 169
Cdd:pfam00858  80 YSALKELSLFYDNLSfllylkfkfLEKILKSLTSNTEELEDELKLLLDFTNELLNSLSGYILNLGLRCEDLIVSCSFGGE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948    170 --PCGpENFTTIFTRMGKCYTFNSGADGAEL--LTTTRGGMGNGLDIMLDVQQEE-YLPVWRdneetpFEVGIRVQIHSQ 244
Cdd:pfam00858 160 keDCS-ANFTPILTEYGNCYTFNSKDNGSKLypRRLKGAGSGRGLSLILNIQQSEtYSPLDY------QAAGFKVSIHSP 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948    245 EEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYepepsdplgspspspSPPYTLMGCRLACETRYV 324
Cdd:pfam00858 233 GEPPDVDKRGFSVPPGTETSVGIQPTEITTLKRPYGNCTFDDEKLLY---------------FKSYSQSNCLLECRQNYI 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948    325 ARKCGCRMVYMPGDVPVCSPQQYKnCAHPAIDAML---RKDSCA-CPNPCASTRYAKELSMVRIPSRAAARFLARKLN-- 398
Cdd:pfam00858 298 LKLCGCVPFFYPLPPGTKTGADIP-CLLNYEDHLLevnEGLSCQdCLPPCNETEYETEISYSTWPSLSSQLFLLYYELst 376
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 9998948    399 --RSEAYIAENVLALDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDY 459
Cdd:pfam00858 377 ynNSSSTIRENLAKLNIYFKELNYETYRRSPAYTWTDLLSSIGGQLGLFLGASVLSLVEIVYF 439
 
Name Accession Description Interval E-value
ENaC TIGR00859
sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC ...
20-523 1.70e-180

sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the vertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273304 [Multi-domain]  Cd Length: 595  Bit Score: 520.83  E-value: 1.70e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948     20 FASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALDeRESHRLIFPAVTLCNINPLRR 99
Cdd:TIGR00859   9 FCNNTTTHGAIRIVCSRGGRLKRALWALLTLLALALLLWQCGLLVRYYLSYPVSVSLS-VNSDKLTFPAVTLCNLNPYRY 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948    100 S----RLTPNDLHWAGSALLGLDPAE------------------------------------------------------ 121
Cdd:TIGR00859  88 SkvkhLLEELDLETAQTLLSLYGYNSslarsarsnnrnriplvvldetlprhpvprdlftrqvhnklisnrsnspqvnas 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948    122 -----------------HAAFLRALGRPPAPPGFMPSPTFD--MAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIFT- 181
Cdd:TIGR00859 168 dwkvgfklcnnngsdcfYRTYTSGVQAVREWYRFHYINIFAqvPAEDKDRMGYQLEDFILTCRFDGESCDARNFTHFHHp 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948    182 RMGKCYTFNSGADgAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDneetpfEVGIRVQIHSQEEPPIIDQLGLGVSPGY 261
Cdd:TIGR00859 248 MYGNCYTFNSGEN-SNLLTSSMPGAENGLKLVLDIEQDEYLPLLST------EAGARVMVHSQDEPPFIDDLGFGVRPGT 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948    262 QTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPepsdplgspspSPSPPYTLMGCRLACETRYVARKCGCRMVYMP--GDV 339
Cdd:TIGR00859 321 ETSISMQEDELQRLGGPYGDCTENGSDVPVEN-----------LYNSSYSIQACLRSCFQRYMVENCGCAYYHYPlpGGA 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948    340 PVCSPQQYKNCAHPAIDAMLRKDS------CACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAY----IAENVL 409
Cdd:TIGR00859 390 EYCNYEQHPDWAYCYYKLYAEFDQeelgcfSVCREPCNFTEYKLTLSMARWPSAASEDWLLHVLSRQNEYnitlIRNGIA 469
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948    410 ALDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWN--RQHSQRHSSTNLT 487
Cdd:TIGR00859 470 KLNIFFEELNYRTIEESPAYNVVTLLSNLGGQMGLWMGASVLCVLELLELIIDLIFITLLRLLWRfrKWWQRRRGPPYAE 549
                         570       580       590
                  ....*....|....*....|....*....|....*.
gi 9998948    488 SHPSLCRHQDSLRLPPHLLPCHTALDLLSVSSEPRP 523
Cdd:TIGR00859 550 PPEPVSADTPPSLQLDDPPTFPSALPLPHASGLSLP 585
ASC pfam00858
Amiloride-sensitive sodium channel;
20-459 3.72e-118

Amiloride-sensitive sodium channel;


Pssm-ID: 459966 [Multi-domain]  Cd Length: 439  Bit Score: 356.09  E-value: 3.72e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948     20 FASNCSMHGLGHVFGpGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALDERE-SHRLIFPAVTLCNINPLR 98
Cdd:pfam00858   1 FCENTSIHGVRYIKS-KDGFLRRLFWLLLFLASLIFLIYLISLLFEKYLSYPVITVIEEILyVWNVPFPAVTICNLNPFR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948     99 RSRLTPNDLHWAGSA---------LLGLDPAEHAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQ 169
Cdd:pfam00858  80 YSALKELSLFYDNLSfllylkfkfLEKILKSLTSNTEELEDELKLLLDFTNELLNSLSGYILNLGLRCEDLIVSCSFGGE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948    170 --PCGpENFTTIFTRMGKCYTFNSGADGAEL--LTTTRGGMGNGLDIMLDVQQEE-YLPVWRdneetpFEVGIRVQIHSQ 244
Cdd:pfam00858 160 keDCS-ANFTPILTEYGNCYTFNSKDNGSKLypRRLKGAGSGRGLSLILNIQQSEtYSPLDY------QAAGFKVSIHSP 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948    245 EEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYepepsdplgspspspSPPYTLMGCRLACETRYV 324
Cdd:pfam00858 233 GEPPDVDKRGFSVPPGTETSVGIQPTEITTLKRPYGNCTFDDEKLLY---------------FKSYSQSNCLLECRQNYI 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948    325 ARKCGCRMVYMPGDVPVCSPQQYKnCAHPAIDAML---RKDSCA-CPNPCASTRYAKELSMVRIPSRAAARFLARKLN-- 398
Cdd:pfam00858 298 LKLCGCVPFFYPLPPGTKTGADIP-CLLNYEDHLLevnEGLSCQdCLPPCNETEYETEISYSTWPSLSSQLFLLYYELst 376
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 9998948    399 --RSEAYIAENVLALDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDY 459
Cdd:pfam00858 377 ynNSSSTIRENLAKLNIYFKELNYETYRRSPAYTWTDLLSSIGGQLGLFLGASVLSLVEIVYF 439
deg-1 TIGR00867
degenerin; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of ...
144-457 2.41e-41

degenerin; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the invertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273309 [Multi-domain]  Cd Length: 600  Bit Score: 157.31  E-value: 2.41e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948    144 FDMAQLY----ARAGHSLDDMLLDCRFRGQPCGPE-NFTT-IFTRMGKCYTFNsgADGAELLTTTRGGMGNGLDIMLDVQ 217
Cdd:TIGR00867 288 FAMAALSdkarEALSYTKHELILKCSFNGKPCDIDrDFTLhIDPVFGNCYTFN--YNRSVNLSSSRAGPMYGLRLLLFVN 365
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948    218 QEEYLPvwrdneeTPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCS-----SASLNPNYE 292
Cdd:TIGR00867 366 QSDYLP-------TTEAAGVRLTIHDKDEFPFPDTFGYSAPTGYISSFGVRLKQMSRLPAPYGNCVdtgkdSSYIYKGYI 438
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948    293 pepsdplgspspspsppYTLMGCRLACETRYVARKCGCrmvympGDVPVCSPQQYKNCAHPAIDAM--LRK--------- 361
Cdd:TIGR00867 439 -----------------YSPEGCHRSCFQRLIIAKCGC------ADPRFPVPEGTRHCQAFNKTDRecLETltgdlgelh 495
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9998948    362 ---DSCACPNPCASTRYAKELSMVRIPSRAAARFLAR-KLNRSEA---YIAENVLALDIFFEALNYETVEQKKAYEMSEL 434
Cdd:TIGR00867 496 hsiFKCRCQQPCQESIYTTTYSAAKWPSGSLKITLGScDSNTASEcneYYRENAAMIEVFYEQLNYELLTESEAYTLVNL 575
                         330       340
                  ....*....|....*....|...
gi 9998948    435 LGDIGGQMGLFIGASLLTILEIL 457
Cdd:TIGR00867 576 IADFGGQLGLWLGASVITVCEFV 598
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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