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Conserved domains on  [gi|992271766|gb|EES00342|]
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hypothetical protein SORBI_3003G077600 [Sorghum bicolor]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
193-523 1.14e-13

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.02  E-value: 1.14e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992271766 193 HQRRVTCLEFHPTkNNVLLSGDKKGLLGIWDYVKLHEKITY----DSVHSCILNSmkidttnDG-MVYTASSDGTISFTD 267
Cdd:COG2319   77 HTAAVLSVAFSPD-GRLLASASADGTVRLWDLATGLLLRTLtghtGAVRSVAFSP-------DGkTLASGSADGTVRLWD 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992271766 268 LDTGigsPLLNLnpngWNGPSSWhmIYGMDLNTDKGLLLVADNFGFLYFLDRRSKTRIgHPILIHKKGskVTSLHCNPAR 347
Cdd:COG2319  149 LATG---KLLRT----LTGHSGA--VTSVAFSPDGKLLASGSDDGTVRLWDLATGKLL-RTLTGHTGA--VRSVAFSPDG 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992271766 348 pEVLLSSGNDHYARIWDtrkLEANSPLASLA-HGRVVNSGYFSPrSGNKILTTCQDNRIRVWdyilgDLQSPSREIVHSH 426
Cdd:COG2319  217 -KLLASGSADGTVRLWD---LATGKLLRTLTgHSGSVRSVAFSP-DGRLLASGSADGTVRLW-----DLATGELLRTLTG 286

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992271766 427 DFNRHLTpfkAEWDPkDytetvaviGRYI-SENYNGValhpIDFIDTSSGKLLAEVMDP--DITTISpvnkLHPQDDILA 503
Cdd:COG2319  287 HSGGVNS---VAFSP-D--------GKLLaSGSDDGT----VRLWDLATGKLLRTLTGHtgAVRSVA----FSPDGKTLA 346

                        330       340
                 ....*....|....*....|.
gi 992271766 504 TGSS-RSIFIWKPKTEDELTE 523
Cdd:COG2319  347 SGSDdGTVRLWDLATGELLRT 367
AIR1 super family cl34894
Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational ...
 98-139 5.51e-04

Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5082:

Pssm-ID: 227414 [Multi-domain]  Cd Length: 190  Bit Score: 41.37  E-value: 5.51e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 992271766  98 KVCKVCKRTGHQAgfqgavyIDCPMKPCFLCKMPGHTTLTCP 139
Cdd:COG5082   61 PVCFNCGQNGHLR-------RDCPHSICYNCSWDGHRSNHCP 95
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
193-523 1.14e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.02  E-value: 1.14e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992271766 193 HQRRVTCLEFHPTkNNVLLSGDKKGLLGIWDYVKLHEKITY----DSVHSCILNSmkidttnDG-MVYTASSDGTISFTD 267
Cdd:COG2319   77 HTAAVLSVAFSPD-GRLLASASADGTVRLWDLATGLLLRTLtghtGAVRSVAFSP-------DGkTLASGSADGTVRLWD 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992271766 268 LDTGigsPLLNLnpngWNGPSSWhmIYGMDLNTDKGLLLVADNFGFLYFLDRRSKTRIgHPILIHKKGskVTSLHCNPAR 347
Cdd:COG2319  149 LATG---KLLRT----LTGHSGA--VTSVAFSPDGKLLASGSDDGTVRLWDLATGKLL-RTLTGHTGA--VRSVAFSPDG 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992271766 348 pEVLLSSGNDHYARIWDtrkLEANSPLASLA-HGRVVNSGYFSPrSGNKILTTCQDNRIRVWdyilgDLQSPSREIVHSH 426
Cdd:COG2319  217 -KLLASGSADGTVRLWD---LATGKLLRTLTgHSGSVRSVAFSP-DGRLLASGSADGTVRLW-----DLATGELLRTLTG 286

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992271766 427 DFNRHLTpfkAEWDPkDytetvaviGRYI-SENYNGValhpIDFIDTSSGKLLAEVMDP--DITTISpvnkLHPQDDILA 503
Cdd:COG2319  287 HSGGVNS---VAFSP-D--------GKLLaSGSDDGT----VRLWDLATGKLLRTLTGHtgAVRSVA----FSPDGKTLA 346

                        330       340
                 ....*....|....*....|.
gi 992271766 504 TGSS-RSIFIWKPKTEDELTE 523
Cdd:COG2319  347 SGSDdGTVRLWDLATGELLRT 367
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 190-409 1.76e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.13  E-value: 1.76e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992271766 190 IKFHQRRVTCLEFHPtKNNVLLSGDKKGLLGIWDYVKLHEKITY----DSVHSCILNSmkidttNDGMVYTASSDGTISF 265
Cdd:cd00200    5 LKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLkghtGPVRDVAASA------DGTYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992271766 266 TDLDTGigspllnlnpngwNGPSSWH----MIYGMDLNTDKGLLLVADNFGFLYFLDRRSKTRIgHPILIHKKGskVTSL 341
Cdd:cd00200   78 WDLETG-------------ECVRTLTghtsYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCL-TTLRGHTDW--VNSV 141

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 992271766 342 HCNPArPEVLLSSGNDHYARIWDtrkLEANSPLASL-AHGRVVNSGYFSPrSGNKILTTCQDNRIRVWD 409
Cdd:cd00200  142 AFSPD-GTFVASSSQDGTIKLWD---LRTGKCVATLtGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWD 205
AIR1 COG5082
Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational ...
 98-139 5.51e-04

Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion];


Pssm-ID: 227414 [Multi-domain]  Cd Length: 190  Bit Score: 41.37  E-value: 5.51e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 992271766  98 KVCKVCKRTGHQAgfqgavyIDCPMKPCFLCKMPGHTTLTCP 139
Cdd:COG5082   61 PVCFNCGQNGHLR-------RDCPHSICYNCSWDGHRSNHCP 95
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
193-523 1.14e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.02  E-value: 1.14e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992271766 193 HQRRVTCLEFHPTkNNVLLSGDKKGLLGIWDYVKLHEKITY----DSVHSCILNSmkidttnDG-MVYTASSDGTISFTD 267
Cdd:COG2319   77 HTAAVLSVAFSPD-GRLLASASADGTVRLWDLATGLLLRTLtghtGAVRSVAFSP-------DGkTLASGSADGTVRLWD 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992271766 268 LDTGigsPLLNLnpngWNGPSSWhmIYGMDLNTDKGLLLVADNFGFLYFLDRRSKTRIgHPILIHKKGskVTSLHCNPAR 347
Cdd:COG2319  149 LATG---KLLRT----LTGHSGA--VTSVAFSPDGKLLASGSDDGTVRLWDLATGKLL-RTLTGHTGA--VRSVAFSPDG 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992271766 348 pEVLLSSGNDHYARIWDtrkLEANSPLASLA-HGRVVNSGYFSPrSGNKILTTCQDNRIRVWdyilgDLQSPSREIVHSH 426
Cdd:COG2319  217 -KLLASGSADGTVRLWD---LATGKLLRTLTgHSGSVRSVAFSP-DGRLLASGSADGTVRLW-----DLATGELLRTLTG 286

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992271766 427 DFNRHLTpfkAEWDPkDytetvaviGRYI-SENYNGValhpIDFIDTSSGKLLAEVMDP--DITTISpvnkLHPQDDILA 503
Cdd:COG2319  287 HSGGVNS---VAFSP-D--------GKLLaSGSDDGT----VRLWDLATGKLLRTLTGHtgAVRSVA----FSPDGKTLA 346

                        330       340
                 ....*....|....*....|.
gi 992271766 504 TGSS-RSIFIWKPKTEDELTE 523
Cdd:COG2319  347 SGSDdGTVRLWDLATGELLRT 367
WD40 COG2319
WD40 repeat [General function prediction only];
193-409 1.27e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.02  E-value: 1.27e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992271766 193 HQRRVTCLEFHPtKNNVLLSGDKKGLLGIWDYVKLHEKITYDSvHSCILNSmkIDTTNDG-MVYTASSDGTISFTDLDTG 271
Cdd:COG2319  203 HTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTG-HSGSVRS--VAFSPDGrLLASGSADGTVRLWDLATG 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992271766 272 igSPLLNLNpngwnGPSSWhmIYGMDLNTDKGLLLVADNFGFLYFLDRRSktriGHPILIHK-KGSKVTSLHCNPARpEV 350
Cdd:COG2319  279 --ELLRTLT-----GHSGG--VNSVAFSPDGKLLASGSDDGTVRLWDLAT----GKLLRTLTgHTGAVRSVAFSPDG-KT 344

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 992271766 351 LLSSGNDHYARIWDtrkLEANSPLASL-AHGRVVNSGYFSPrSGNKILTTCQDNRIRVWD 409
Cdd:COG2319  345 LASGSDDGTVRLWD---LATGELLRTLtGHTGAVTSVAFSP-DGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 190-409 1.76e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.13  E-value: 1.76e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992271766 190 IKFHQRRVTCLEFHPtKNNVLLSGDKKGLLGIWDYVKLHEKITY----DSVHSCILNSmkidttNDGMVYTASSDGTISF 265
Cdd:cd00200    5 LKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLkghtGPVRDVAASA------DGTYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992271766 266 TDLDTGigspllnlnpngwNGPSSWH----MIYGMDLNTDKGLLLVADNFGFLYFLDRRSKTRIgHPILIHKKGskVTSL 341
Cdd:cd00200   78 WDLETG-------------ECVRTLTghtsYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCL-TTLRGHTDW--VNSV 141

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 992271766 342 HCNPArPEVLLSSGNDHYARIWDtrkLEANSPLASL-AHGRVVNSGYFSPrSGNKILTTCQDNRIRVWD 409
Cdd:cd00200  142 AFSPD-GTFVASSSQDGTIKLWD---LRTGKCVATLtGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWD 205
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 193-409 4.77e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.89  E-value: 4.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992271766 193 HQRRVTCLEFHPtKNNVLLSGDKKGLLGIWDYVKLHEKITYDSvHSCILNSMKIDTTNDgMVYTASSDGTISFTDLDTgi 272
Cdd:cd00200   92 HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGT-FVASSSQDGTIKLWDLRT-- 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992271766 273 GSPLLNLnpngwNGPSSWhmIYGMDLNTDKGLLLVADNFGFLYFLDRRS----KTRIGHPilihkkgSKVTSLHCNPARp 348
Cdd:cd00200  167 GKCVATL-----TGHTGE--VNSVAFSPDGEKLLSSSSDGTIKLWDLSTgkclGTLRGHE-------NGVNSVAFSPDG- 231

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 992271766 349 EVLLSSGNDHYARIWDTRKLEansPLASL-AHGRVVNSGYFSPrSGNKILTTCQDNRIRVWD 409
Cdd:cd00200  232 YLLASGSEDGTIRVWDLRTGE---CVQTLsGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 190-364 5.18e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 57.73  E-value: 5.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992271766 190 IKFHQRRVTCLEFHPTkNNVLLSGDKKGLLGIWDYVKLHEKITYDSvHSCILNSMKIDTTNDGMVyTASSDGTISFTDLD 269
Cdd:cd00200  131 LRGHTDWVNSVAFSPD-GTFVASSSQDGTIKLWDLRTGKCVATLTG-HTGEVNSVAFSPDGEKLL-SSSSDGTIKLWDLS 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992271766 270 TGIGSPLLNLNPNGwngpsswhmIYGMDLNTDKGLLLVADNFGFLYFLDRRSKTRI----GHPilihkkgSKVTSLHCNP 345
Cdd:cd00200  208 TGKCLGTLRGHENG---------VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVqtlsGHT-------NSVTSLAWSP 271

                        170
                 ....*....|....*....
gi 992271766 346 ARPeVLLSSGNDHYARIWD 364
Cdd:cd00200  272 DGK-RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
190-366 1.58e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.68  E-value: 1.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992271766 190 IKFHQRRVTCLEFHPtKNNVLLSGDKKGLLGIWDyVKLHEKITYDSVHSCILNSMKIdtTNDG-MVYTASSDGTISFTDL 268
Cdd:COG2319  242 LTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWD-LATGELLRTLTGHSGGVNSVAF--SPDGkLLASGSDDGTVRLWDL 317

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992271766 269 DTGigsPLLNlnpnGWNGPSSWhmIYGMDLNTDKGLLLVADNFGFLYFLDRRSKTRI----GHpilihkkGSKVTSLHCN 344
Cdd:COG2319  318 ATG---KLLR----TLTGHTGA--VRSVAFSPDGKTLASGSDDGTVRLWDLATGELLrtltGH-------TGAVTSVAFS 381

                        170       180
                 ....*....|....*....|..
gi 992271766 345 PArPEVLLSSGNDHYARIWDTR 366
Cdd:COG2319  382 PD-GRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 336-521 1.33e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.33  E-value: 1.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992271766 336 SKVTSLHCNPArPEVLLSSGNDHYARIWDtrkLEANSPLASL-AHGRVVNSGYFSPrSGNKILTTCQDNRIRVWDYILGD 414
Cdd:cd00200   10 GGVTCVAFSPD-GKLLATGSGDGTIKVWD---LETGELLRTLkGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLETGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992271766 415 LqspSREIV-HSH-----DFNRHLTPFKA--------EWDPKDYTETVAVIGryISENYNGVALHP-------------I 467
Cdd:cd00200   85 C---VRTLTgHTSyvssvAFSPDGRILSSssrdktikVWDVETGKCLTTLRG--HTDWVNSVAFSPdgtfvasssqdgtI 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 992271766 468 DFIDTSSGKLLA--EVMDPDITTISpvnkLHPQDDILATGSS-RSIFIWKPKTEDEL 521
Cdd:cd00200  160 KLWDLRTGKCVAtlTGHTGEVNSVA----FSPDGEKLLSSSSdGTIKLWDLSTGKCL 212
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 187-271 9.35e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 44.63  E-value: 9.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 992271766 187 CGNIKFHQRRVTCLEFHPTKNNVLLSGDkKGLLGIWDYVKLHEKITYDSvHSCILNSMKIDTTNDgMVYTASSDGTISFT 266
Cdd:cd00200  170 VATLTGHTGEVNSVAFSPDGEKLLSSSS-DGTIKLWDLSTGKCLGTLRG-HENGVNSVAFSPDGY-LLASGSEDGTIRVW 246


                 ....*
gi 992271766 267 DLDTG 271
Cdd:cd00200  247 DLRTG 251
AIR1 COG5082
Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational ...
 98-139 5.51e-04

Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion];


Pssm-ID: 227414 [Multi-domain]  Cd Length: 190  Bit Score: 41.37  E-value: 5.51e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 992271766  98 KVCKVCKRTGHQAgfqgavyIDCPMKPCFLCKMPGHTTLTCP 139
Cdd:COG5082   61 PVCFNCGQNGHLR-------RDCPHSICYNCSWDGHRSNHCP 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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