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Conserved domains on  [gi|987943029|ref|XP_015418518|]
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PREDICTED: baculoviral IAP repeat-containing protein 1 isoform X1 [Myotis davidii]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NLRC4_HD pfam17889
NLRC4 helical domain; This is a helical domain found in NLRC4, Nucleotide-binding and ...
 765-870 4.50e-48

NLRC4 helical domain; This is a helical domain found in NLRC4, Nucleotide-binding and oligomerization domain-like receptor (NLR) proteins. Structural and functional studies indicate that the helical domain HD2 repressively contacted a conserved and functionally important alpha-helix of the NBD (nucleotide binding domain) in Swiss:Q3UP24. Furthermore, the HD2 domain was shown to cap the N-terminal side of the LRR (leucine-rich repeat) domain via extensive interactions. Other family members carrying this domain include baculoviral IAP repeat-containing protein 1 (Birc1) also known as neuronal apoptosis inhibitory protein (Naip).


:

Pssm-ID: 436120  Cd Length: 106  Bit Score: 166.69  E-value: 4.50e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029   765 EDQDLGLYYLKQIHSSMMTLSSCNNFLTYvSCYPSTKAGPKIVSHLLHLLDNKKSLENLSEKDD-LKHHLEVSERVHLCR 843
Cdd:pfam17889    1 EDQDLGLYYLKQINSILKAVSRYNNFLLY-TCHSSTKAGPKIVSHLLHLVDHKESLENLSENDDyLKHHPETSLLMQNIR 79

                           90       100
                   ....*....|....*....|....*..
gi 987943029   844 SLWQLAPEDCFSLISKHLLTFAIKIAY 870
Cdd:pfam17889   80 SLWQLSPELYLSSVSEHLLSLALEIAY 106
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 463-617 6.07e-38

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


:

Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 140.13  E-value: 6.07e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029   463 SVMCVEGEAGSGKTVLLKKIALLWASGCCPLLnrFQLVFYLSLSSTRLDQ---GLANIICDQLLETEGSVTEmsLRIIMQ 539
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQG--FDFVFFLPCRELSRSGnarSLADLLFSQWPEPAAPVSE--VWAVIL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029   540 QLKNQVLFLLDDYKEMCSVPQ----------VIQKLIHKNHSSRTCLLIAVRTNRTRDIRQHLHT--ILEIKPFPFYNTV 607
Cdd:pfam05729   77 ELPERLLLILDGLDELVSDLGqldgpcpvltLLSSLLRKKLLPGASLLLTVRPDALRDLRRGLEEprYLEVRGFSESDRK 156

                          170
                   ....*....|
gi 987943029   608 YILRKFFSHD 617
Cdd:pfam05729  157 QYVRKYFSDE 166
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 162-228 2.68e-32

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


:

Pssm-ID: 459891  Cd Length: 68  Bit Score: 120.07  E-value: 2.68e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 987943029   162 RLESFHDWPFYAHGT-SPPELSAAGFVFTGKRDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLQ 228
Cdd:pfam00653    1 RLATFENWPHSNKSPpTPEELAEAGFYYTGTGDRVQCFYCGLELDGWEEGDDPWEEHKKHSPDCPFLK 68
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 281-345 3.30e-24

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


:

Pssm-ID: 459891  Cd Length: 68  Bit Score: 96.96  E-value: 3.30e-24
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 987943029   281 RQESFKKWPHA---SPGGAALAKAGLFYIGIEDIVQCFSCGGCMNNWVEDDDPLGDHSKYFPDCLFLQ 345
Cdd:pfam00653    1 RLATFENWPHSnksPPTPEELAEAGFYYTGTGDRVQCFYCGLELDGWEEGDDPWEEHKKHSPDCPFLK 68
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 61-129 1.74e-23

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


:

Pssm-ID: 237989  Cd Length: 69  Bit Score: 95.03  E-value: 1.74e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 987943029   61 AKRLKTFVTYDSYSSWTPQEMAAAGFYFTGIKSGVQCFCCSLILFCTTLKRLPIEHHKKFSPHCEFLLG 129
Cdd:cd00022     1 EARLKTFKNWPISLKVTPEKLAEAGFYYTGRGDEVKCFFCGLELKNWEPGDDPWEEHKRWSPNCPFVLL 69
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
357-765 1.49e-22

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


:

Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 105.27  E-value: 1.49e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029  357 LQSHDELSELAETISETSLEDSAAVSSLVQETAQSEAQWFGEAKSLNQRLKEAYTDASFRRMYmlEVSSSLATDHLLSCD 436
Cdd:COG5635    59 LALVSRSALSAAALLARALSALLLVLLLLESLLLLLLLLLLLAEALLALLELAALLKAVLLSL--SGGSDLVLLLSESDL 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029  437 LSLASKHISTPVQKPVVLSDVFANLN------------------SVMCVEGEAGSGKTVLLKKIALLWASGCCPLLNRfq 498
Cdd:COG5635   137 LLALLILLLDADGLLVSLDDLYVPLNllerieslkrlelleakkKRLLILGEPGSGKTTLLRYLALELAERYLDAEDP-- 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029  499 LVFYLSLSSTRLDQGLANIICDQLLETEGSVTEmslrIIMQQLKN-QVLFLLDDYKEM---CSVPQVIQKLIH-KNHSSR 573
Cdd:COG5635   215 IPILIELRDLAEEASLEDLLAEALEKRGGEPED----ALERLLRNgRLLLLLDGLDEVpdeADRDEVLNQLRRfLERYPK 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029  574 TCLLIAVRTNRTRDIRQHLHTILEIKPFPFYNTVYILRKFFSHDLTRLQKFMIHFKMNENLQGIQKTPLFVAAVCANWFR 653
Cdd:COG5635   291 ARVIITSRPEGYDSSELEGFEVLELAPLSDEQIEEFLKKWFEATERKAERLLEALEENPELRELARNPLLLTLLALLLRE 370

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029  654 N---PFDRSydhvTVFKSYIECL----------SLKHKLSAERFKANVSscgKLALKGFFSSCFEFSDDDLveagvdeDE 720
Cdd:COG5635   371 RgelPDTRA----ELYEQFVELLlerwdeqrglTIYRELSREELRELLS---ELALAMQENGRTEFAREEL-------EE 436

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029  721 DLTMCLMSKFTAQRL---------------RPVYQFLDPAFQDFLAGMGLIVLLDSDRQE 765
Cdd:COG5635   437 ILREYLGRRKDAEALldelllrtgllvergEGRYSFAHRSFQEYLAARALVEELDEELLE 496
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1030-1243 2.98e-11

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.27  E-value: 2.98e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029 1030 IELHLRGSRGFIESLRPAIEQYKASFTKCSINESELNAVEQELLLNLPSLESLEVSGT--TQIPDqlfpNLDKFPCLKEL 1107
Cdd:COG4886    66 LLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNqlTDLPE----ELANLTNLKEL 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029 1108 SVNmdkKNVFSVIPEEFLKLHNMEKLLIeisAENGPSKIVKLIENSPNLNVFHLQCNFFSDFESlltVLASCKKLKEIKF 1187
Cdd:COG4886   142 DLS---NNQLTDLPEPLGNLTNLKSLDL---SNNQLTDLPEELGNLTNLKELDLSNNQITDLPE---PLGNLTNLEELDL 212

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 987943029 1188 SGAFFKPIPFVtiLTNFISLKILDL---KFQEFPhketsekfahTLGSLSSLEELILPN 1243
Cdd:COG4886   213 SGNQLTDLPEP--LANLTNLETLDLsnnQLTDLP----------ELGNLTNLEELDLSN 259
 
Name Accession Description Interval E-value
NLRC4_HD pfam17889
NLRC4 helical domain; This is a helical domain found in NLRC4, Nucleotide-binding and ...
 765-870 4.50e-48

NLRC4 helical domain; This is a helical domain found in NLRC4, Nucleotide-binding and oligomerization domain-like receptor (NLR) proteins. Structural and functional studies indicate that the helical domain HD2 repressively contacted a conserved and functionally important alpha-helix of the NBD (nucleotide binding domain) in Swiss:Q3UP24. Furthermore, the HD2 domain was shown to cap the N-terminal side of the LRR (leucine-rich repeat) domain via extensive interactions. Other family members carrying this domain include baculoviral IAP repeat-containing protein 1 (Birc1) also known as neuronal apoptosis inhibitory protein (Naip).


Pssm-ID: 436120  Cd Length: 106  Bit Score: 166.69  E-value: 4.50e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029   765 EDQDLGLYYLKQIHSSMMTLSSCNNFLTYvSCYPSTKAGPKIVSHLLHLLDNKKSLENLSEKDD-LKHHLEVSERVHLCR 843
Cdd:pfam17889    1 EDQDLGLYYLKQINSILKAVSRYNNFLLY-TCHSSTKAGPKIVSHLLHLVDHKESLENLSENDDyLKHHPETSLLMQNIR 79

                           90       100
                   ....*....|....*....|....*..
gi 987943029   844 SLWQLAPEDCFSLISKHLLTFAIKIAY 870
Cdd:pfam17889   80 SLWQLSPELYLSSVSEHLLSLALEIAY 106
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 463-617 6.07e-38

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 140.13  E-value: 6.07e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029   463 SVMCVEGEAGSGKTVLLKKIALLWASGCCPLLnrFQLVFYLSLSSTRLDQ---GLANIICDQLLETEGSVTEmsLRIIMQ 539
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQG--FDFVFFLPCRELSRSGnarSLADLLFSQWPEPAAPVSE--VWAVIL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029   540 QLKNQVLFLLDDYKEMCSVPQ----------VIQKLIHKNHSSRTCLLIAVRTNRTRDIRQHLHT--ILEIKPFPFYNTV 607
Cdd:pfam05729   77 ELPERLLLILDGLDELVSDLGqldgpcpvltLLSSLLRKKLLPGASLLLTVRPDALRDLRRGLEEprYLEVRGFSESDRK 156

                          170
                   ....*....|
gi 987943029   608 YILRKFFSHD 617
Cdd:pfam05729  157 QYVRKYFSDE 166
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 162-228 2.68e-32

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


Pssm-ID: 459891  Cd Length: 68  Bit Score: 120.07  E-value: 2.68e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 987943029   162 RLESFHDWPFYAHGT-SPPELSAAGFVFTGKRDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLQ 228
Cdd:pfam00653    1 RLATFENWPHSNKSPpTPEELAEAGFYYTGTGDRVQCFYCGLELDGWEEGDDPWEEHKKHSPDCPFLK 68
BIR smart00238
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ...
 159-229 2.57e-31

Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.


Pssm-ID: 197595  Cd Length: 71  Bit Score: 117.42  E-value: 2.57e-31
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 987943029    159 EKARLESFHDWPFYAHgTSPPELSAAGFVFTGKRDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLQR 229
Cdd:smart00238    2 EEARLKTFQNWPYNSK-CTPEQLAEAGFYYTGVGDEVKCFFCGGELDNWEPGDDPWEEHKKWSPNCPFVRN 71
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 160-228 1.03e-29

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


Pssm-ID: 237989  Cd Length: 69  Bit Score: 112.74  E-value: 1.03e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 987943029  160 KARLESFHDWPfYAHGTSPPELSAAGFVFTGKRDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLQ 228
Cdd:cd00022     1 EARLKTFKNWP-ISLKVTPEKLAEAGFYYTGRGDEVKCFFCGLELKNWEPGDDPWEEHKRWSPNCPFVL 68
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 281-345 3.30e-24

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


Pssm-ID: 459891  Cd Length: 68  Bit Score: 96.96  E-value: 3.30e-24
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 987943029   281 RQESFKKWPHA---SPGGAALAKAGLFYIGIEDIVQCFSCGGCMNNWVEDDDPLGDHSKYFPDCLFLQ 345
Cdd:pfam00653    1 RLATFENWPHSnksPPTPEELAEAGFYYTGTGDRVQCFYCGLELDGWEEGDDPWEEHKKHSPDCPFLK 68
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 61-129 1.74e-23

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


Pssm-ID: 237989  Cd Length: 69  Bit Score: 95.03  E-value: 1.74e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 987943029   61 AKRLKTFVTYDSYSSWTPQEMAAAGFYFTGIKSGVQCFCCSLILFCTTLKRLPIEHHKKFSPHCEFLLG 129
Cdd:cd00022     1 EARLKTFKNWPISLKVTPEKLAEAGFYYTGRGDEVKCFFCGLELKNWEPGDDPWEEHKRWSPNCPFVLL 69
BIR smart00238
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ...
 59-129 2.03e-23

Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.


Pssm-ID: 197595  Cd Length: 71  Bit Score: 95.08  E-value: 2.03e-23
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 987943029     59 SEAKRLKTFVTYDSYSSWTPQEMAAAGFYFTGIKSGVQCFCCSLILFCTTLKRLPIEHHKKFSPHCEFLLG 129
Cdd:smart00238    1 SEEARLKTFQNWPYNSKCTPEQLAEAGFYYTGVGDEVKCFFCGGELDNWEPGDDPWEEHKKWSPNCPFVRN 71
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 279-346 2.30e-23

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


Pssm-ID: 237989  Cd Length: 69  Bit Score: 94.64  E-value: 2.30e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 987943029  279 ELRQESFKKWPHASP-GGAALAKAGLFYIGIEDIVQCFSCGGCMNNWVEDDDPLGDHSKYFPDCLFLQN 346
Cdd:cd00022     1 EARLKTFKNWPISLKvTPEKLAEAGFYYTGRGDEVKCFFCGLELKNWEPGDDPWEEHKRWSPNCPFVLL 69
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 63-127 3.55e-23

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


Pssm-ID: 459891  Cd Length: 68  Bit Score: 94.26  E-value: 3.55e-23
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 987943029    63 RLKTFVTY--DSYSSWTPQEMAAAGFYFTGIKSGVQCFCCSLILFCTTLKRLPIEHHKKFSPHCEFL 127
Cdd:pfam00653    1 RLATFENWphSNKSPPTPEELAEAGFYYTGTGDRVQCFYCGLELDGWEEGDDPWEEHKKHSPDCPFL 67
BIR smart00238
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ...
 277-346 3.61e-23

Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.


Pssm-ID: 197595  Cd Length: 71  Bit Score: 94.31  E-value: 3.61e-23
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 987943029    277 NEELRQESFKKWPHAS-PGGAALAKAGLFYIGIEDIVQCFSCGGCMNNWVEDDDPLGDHSKYFPDCLFLQN 346
Cdd:smart00238    1 SEEARLKTFQNWPYNSkCTPEQLAEAGFYYTGVGDEVKCFFCGGELDNWEPGDDPWEEHKKWSPNCPFVRN 71
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
357-765 1.49e-22

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 105.27  E-value: 1.49e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029  357 LQSHDELSELAETISETSLEDSAAVSSLVQETAQSEAQWFGEAKSLNQRLKEAYTDASFRRMYmlEVSSSLATDHLLSCD 436
Cdd:COG5635    59 LALVSRSALSAAALLARALSALLLVLLLLESLLLLLLLLLLLAEALLALLELAALLKAVLLSL--SGGSDLVLLLSESDL 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029  437 LSLASKHISTPVQKPVVLSDVFANLN------------------SVMCVEGEAGSGKTVLLKKIALLWASGCCPLLNRfq 498
Cdd:COG5635   137 LLALLILLLDADGLLVSLDDLYVPLNllerieslkrlelleakkKRLLILGEPGSGKTTLLRYLALELAERYLDAEDP-- 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029  499 LVFYLSLSSTRLDQGLANIICDQLLETEGSVTEmslrIIMQQLKN-QVLFLLDDYKEM---CSVPQVIQKLIH-KNHSSR 573
Cdd:COG5635   215 IPILIELRDLAEEASLEDLLAEALEKRGGEPED----ALERLLRNgRLLLLLDGLDEVpdeADRDEVLNQLRRfLERYPK 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029  574 TCLLIAVRTNRTRDIRQHLHTILEIKPFPFYNTVYILRKFFSHDLTRLQKFMIHFKMNENLQGIQKTPLFVAAVCANWFR 653
Cdd:COG5635   291 ARVIITSRPEGYDSSELEGFEVLELAPLSDEQIEEFLKKWFEATERKAERLLEALEENPELRELARNPLLLTLLALLLRE 370

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029  654 N---PFDRSydhvTVFKSYIECL----------SLKHKLSAERFKANVSscgKLALKGFFSSCFEFSDDDLveagvdeDE 720
Cdd:COG5635   371 RgelPDTRA----ELYEQFVELLlerwdeqrglTIYRELSREELRELLS---ELALAMQENGRTEFAREEL-------EE 436

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029  721 DLTMCLMSKFTAQRL---------------RPVYQFLDPAFQDFLAGMGLIVLLDSDRQE 765
Cdd:COG5635   437 ILREYLGRRKDAEALldelllrtgllvergEGRYSFAHRSFQEYLAARALVEELDEELLE 496
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1030-1243 2.98e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.27  E-value: 2.98e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029 1030 IELHLRGSRGFIESLRPAIEQYKASFTKCSINESELNAVEQELLLNLPSLESLEVSGT--TQIPDqlfpNLDKFPCLKEL 1107
Cdd:COG4886    66 LLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNqlTDLPE----ELANLTNLKEL 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029 1108 SVNmdkKNVFSVIPEEFLKLHNMEKLLIeisAENGPSKIVKLIENSPNLNVFHLQCNFFSDFESlltVLASCKKLKEIKF 1187
Cdd:COG4886   142 DLS---NNQLTDLPEPLGNLTNLKSLDL---SNNQLTDLPEELGNLTNLKELDLSNNQITDLPE---PLGNLTNLEELDL 212

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 987943029 1188 SGAFFKPIPFVtiLTNFISLKILDL---KFQEFPhketsekfahTLGSLSSLEELILPN 1243
Cdd:COG4886   213 SGNQLTDLPEP--LANLTNLETLDLsnnQLTDLP----------ELGNLTNLEELDLSN 259
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 462-592 1.85e-05

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 46.21  E-value: 1.85e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029    462 NSVMCVEGEAGSGKTVLLKKIALLwasgccpLLNRFQLVFYLSLSSTRLDQGLANIICDQLLETEGSVTEMSLRIIMQQL 541
Cdd:smart00382    2 GEVILIVGPPGSGKTTLARALARE-------LGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALA 74

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029    542 KNQ---VLFL------LDDYKEMCSVPQVIQKLIHKNHSSRTCLLIAVrTNRTRDIRQHL 592
Cdd:smart00382   75 RKLkpdVLILdeitslLDAEQEALLLLLEELRLLLLLKSEKNLTVILT-TNDEKDLGPAL 133
NOD2_WH pfam17779
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular ...
 688-741 3.98e-04

NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular function is not known.


Pssm-ID: 465501  Cd Length: 57  Bit Score: 39.86  E-value: 3.98e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 987943029   688 VSSCGKLALKGFFSSCFEFSDDDLVEAGVDEDeDLTMCLMSKFTAQRL--RPVYQF 741
Cdd:pfam17779    3 LLKLGKLAFEGLWKKKLVFSEEDLKEYGLDES-DLSSGLLTEILQKDLgcEKVYSF 57
 
Name Accession Description Interval E-value
NLRC4_HD pfam17889
NLRC4 helical domain; This is a helical domain found in NLRC4, Nucleotide-binding and ...
 765-870 4.50e-48

NLRC4 helical domain; This is a helical domain found in NLRC4, Nucleotide-binding and oligomerization domain-like receptor (NLR) proteins. Structural and functional studies indicate that the helical domain HD2 repressively contacted a conserved and functionally important alpha-helix of the NBD (nucleotide binding domain) in Swiss:Q3UP24. Furthermore, the HD2 domain was shown to cap the N-terminal side of the LRR (leucine-rich repeat) domain via extensive interactions. Other family members carrying this domain include baculoviral IAP repeat-containing protein 1 (Birc1) also known as neuronal apoptosis inhibitory protein (Naip).


Pssm-ID: 436120  Cd Length: 106  Bit Score: 166.69  E-value: 4.50e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029   765 EDQDLGLYYLKQIHSSMMTLSSCNNFLTYvSCYPSTKAGPKIVSHLLHLLDNKKSLENLSEKDD-LKHHLEVSERVHLCR 843
Cdd:pfam17889    1 EDQDLGLYYLKQINSILKAVSRYNNFLLY-TCHSSTKAGPKIVSHLLHLVDHKESLENLSENDDyLKHHPETSLLMQNIR 79

                           90       100
                   ....*....|....*....|....*..
gi 987943029   844 SLWQLAPEDCFSLISKHLLTFAIKIAY 870
Cdd:pfam17889   80 SLWQLSPELYLSSVSEHLLSLALEIAY 106
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 463-617 6.07e-38

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 140.13  E-value: 6.07e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029   463 SVMCVEGEAGSGKTVLLKKIALLWASGCCPLLnrFQLVFYLSLSSTRLDQ---GLANIICDQLLETEGSVTEmsLRIIMQ 539
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQG--FDFVFFLPCRELSRSGnarSLADLLFSQWPEPAAPVSE--VWAVIL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029   540 QLKNQVLFLLDDYKEMCSVPQ----------VIQKLIHKNHSSRTCLLIAVRTNRTRDIRQHLHT--ILEIKPFPFYNTV 607
Cdd:pfam05729   77 ELPERLLLILDGLDELVSDLGqldgpcpvltLLSSLLRKKLLPGASLLLTVRPDALRDLRRGLEEprYLEVRGFSESDRK 156

                          170
                   ....*....|
gi 987943029   608 YILRKFFSHD 617
Cdd:pfam05729  157 QYVRKYFSDE 166
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 162-228 2.68e-32

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


Pssm-ID: 459891  Cd Length: 68  Bit Score: 120.07  E-value: 2.68e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 987943029   162 RLESFHDWPFYAHGT-SPPELSAAGFVFTGKRDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLQ 228
Cdd:pfam00653    1 RLATFENWPHSNKSPpTPEELAEAGFYYTGTGDRVQCFYCGLELDGWEEGDDPWEEHKKHSPDCPFLK 68
BIR smart00238
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ...
 159-229 2.57e-31

Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.


Pssm-ID: 197595  Cd Length: 71  Bit Score: 117.42  E-value: 2.57e-31
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 987943029    159 EKARLESFHDWPFYAHgTSPPELSAAGFVFTGKRDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLQR 229
Cdd:smart00238    2 EEARLKTFQNWPYNSK-CTPEQLAEAGFYYTGVGDEVKCFFCGGELDNWEPGDDPWEEHKKWSPNCPFVRN 71
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 160-228 1.03e-29

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


Pssm-ID: 237989  Cd Length: 69  Bit Score: 112.74  E-value: 1.03e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 987943029  160 KARLESFHDWPfYAHGTSPPELSAAGFVFTGKRDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLQ 228
Cdd:cd00022     1 EARLKTFKNWP-ISLKVTPEKLAEAGFYYTGRGDEVKCFFCGLELKNWEPGDDPWEEHKRWSPNCPFVL 68
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 281-345 3.30e-24

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


Pssm-ID: 459891  Cd Length: 68  Bit Score: 96.96  E-value: 3.30e-24
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 987943029   281 RQESFKKWPHA---SPGGAALAKAGLFYIGIEDIVQCFSCGGCMNNWVEDDDPLGDHSKYFPDCLFLQ 345
Cdd:pfam00653    1 RLATFENWPHSnksPPTPEELAEAGFYYTGTGDRVQCFYCGLELDGWEEGDDPWEEHKKHSPDCPFLK 68
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 61-129 1.74e-23

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


Pssm-ID: 237989  Cd Length: 69  Bit Score: 95.03  E-value: 1.74e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 987943029   61 AKRLKTFVTYDSYSSWTPQEMAAAGFYFTGIKSGVQCFCCSLILFCTTLKRLPIEHHKKFSPHCEFLLG 129
Cdd:cd00022     1 EARLKTFKNWPISLKVTPEKLAEAGFYYTGRGDEVKCFFCGLELKNWEPGDDPWEEHKRWSPNCPFVLL 69
BIR smart00238
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ...
 59-129 2.03e-23

Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.


Pssm-ID: 197595  Cd Length: 71  Bit Score: 95.08  E-value: 2.03e-23
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 987943029     59 SEAKRLKTFVTYDSYSSWTPQEMAAAGFYFTGIKSGVQCFCCSLILFCTTLKRLPIEHHKKFSPHCEFLLG 129
Cdd:smart00238    1 SEEARLKTFQNWPYNSKCTPEQLAEAGFYYTGVGDEVKCFFCGGELDNWEPGDDPWEEHKKWSPNCPFVRN 71
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 279-346 2.30e-23

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


Pssm-ID: 237989  Cd Length: 69  Bit Score: 94.64  E-value: 2.30e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 987943029  279 ELRQESFKKWPHASP-GGAALAKAGLFYIGIEDIVQCFSCGGCMNNWVEDDDPLGDHSKYFPDCLFLQN 346
Cdd:cd00022     1 EARLKTFKNWPISLKvTPEKLAEAGFYYTGRGDEVKCFFCGLELKNWEPGDDPWEEHKRWSPNCPFVLL 69
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 63-127 3.55e-23

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


Pssm-ID: 459891  Cd Length: 68  Bit Score: 94.26  E-value: 3.55e-23
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 987943029    63 RLKTFVTY--DSYSSWTPQEMAAAGFYFTGIKSGVQCFCCSLILFCTTLKRLPIEHHKKFSPHCEFL 127
Cdd:pfam00653    1 RLATFENWphSNKSPPTPEELAEAGFYYTGTGDRVQCFYCGLELDGWEEGDDPWEEHKKHSPDCPFL 67
BIR smart00238
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ...
 277-346 3.61e-23

Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.


Pssm-ID: 197595  Cd Length: 71  Bit Score: 94.31  E-value: 3.61e-23
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 987943029    277 NEELRQESFKKWPHAS-PGGAALAKAGLFYIGIEDIVQCFSCGGCMNNWVEDDDPLGDHSKYFPDCLFLQN 346
Cdd:smart00238    1 SEEARLKTFQNWPYNSkCTPEQLAEAGFYYTGVGDEVKCFFCGGELDNWEPGDDPWEEHKKWSPNCPFVRN 71
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
357-765 1.49e-22

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 105.27  E-value: 1.49e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029  357 LQSHDELSELAETISETSLEDSAAVSSLVQETAQSEAQWFGEAKSLNQRLKEAYTDASFRRMYmlEVSSSLATDHLLSCD 436
Cdd:COG5635    59 LALVSRSALSAAALLARALSALLLVLLLLESLLLLLLLLLLLAEALLALLELAALLKAVLLSL--SGGSDLVLLLSESDL 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029  437 LSLASKHISTPVQKPVVLSDVFANLN------------------SVMCVEGEAGSGKTVLLKKIALLWASGCCPLLNRfq 498
Cdd:COG5635   137 LLALLILLLDADGLLVSLDDLYVPLNllerieslkrlelleakkKRLLILGEPGSGKTTLLRYLALELAERYLDAEDP-- 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029  499 LVFYLSLSSTRLDQGLANIICDQLLETEGSVTEmslrIIMQQLKN-QVLFLLDDYKEM---CSVPQVIQKLIH-KNHSSR 573
Cdd:COG5635   215 IPILIELRDLAEEASLEDLLAEALEKRGGEPED----ALERLLRNgRLLLLLDGLDEVpdeADRDEVLNQLRRfLERYPK 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029  574 TCLLIAVRTNRTRDIRQHLHTILEIKPFPFYNTVYILRKFFSHDLTRLQKFMIHFKMNENLQGIQKTPLFVAAVCANWFR 653
Cdd:COG5635   291 ARVIITSRPEGYDSSELEGFEVLELAPLSDEQIEEFLKKWFEATERKAERLLEALEENPELRELARNPLLLTLLALLLRE 370

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029  654 N---PFDRSydhvTVFKSYIECL----------SLKHKLSAERFKANVSscgKLALKGFFSSCFEFSDDDLveagvdeDE 720
Cdd:COG5635   371 RgelPDTRA----ELYEQFVELLlerwdeqrglTIYRELSREELRELLS---ELALAMQENGRTEFAREEL-------EE 436

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029  721 DLTMCLMSKFTAQRL---------------RPVYQFLDPAFQDFLAGMGLIVLLDSDRQE 765
Cdd:COG5635   437 ILREYLGRRKDAEALldelllrtgllvergEGRYSFAHRSFQEYLAARALVEELDEELLE 496
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1030-1243 2.98e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.27  E-value: 2.98e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029 1030 IELHLRGSRGFIESLRPAIEQYKASFTKCSINESELNAVEQELLLNLPSLESLEVSGT--TQIPDqlfpNLDKFPCLKEL 1107
Cdd:COG4886    66 LLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNqlTDLPE----ELANLTNLKEL 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029 1108 SVNmdkKNVFSVIPEEFLKLHNMEKLLIeisAENGPSKIVKLIENSPNLNVFHLQCNFFSDFESlltVLASCKKLKEIKF 1187
Cdd:COG4886   142 DLS---NNQLTDLPEPLGNLTNLKSLDL---SNNQLTDLPEELGNLTNLKELDLSNNQITDLPE---PLGNLTNLEELDL 212

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 987943029 1188 SGAFFKPIPFVtiLTNFISLKILDL---KFQEFPhketsekfahTLGSLSSLEELILPN 1243
Cdd:COG4886   213 SGNQLTDLPEP--LANLTNLETLDLsnnQLTDLP----------ELGNLTNLEELDLSN 259
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1020-1360 8.75e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.01  E-value: 8.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029 1020 LMAVFSASQHIELHLRGSRGFIESLRPAIEQYKASFTKCSINESELNAVEQELLLNLPSLESLEVSGTTQIPDQLFPNLD 1099
Cdd:COG4886    14 LLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029 1100 KFPCLKELSVNmdkknvfsvIPEEFLKLHNMEKLLIeisAENGPSKIVKLIENSPNLNVFHLQCNffsDFESLLTVLASC 1179
Cdd:COG4886    94 DLTNLTELDLS---------GNEELSNLTNLESLDL---SGNQLTDLPEELANLTNLKELDLSNN---QLTDLPEPLGNL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029 1180 KKLKEIKFSGAFFKPIPFVtiLTNFISLKILDL---KFQEFPHketsekfahTLGSLSSLEELILPNgdgihqvakliiq 1256
Cdd:COG4886   159 TNLKSLDLSNNQLTDLPEE--LGNLTNLKELDLsnnQITDLPE---------PLGNLTNLEELDLSG------------- 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029 1257 qcqhlrclrvlSFFKTLNDdsvmEIAKvaisggFQKLENLDLSLNhKITEegyrnfFQVLDNLPNLQELTISRHytecir 1336
Cdd:COG4886   215 -----------NQLTDLPE----PLAN------LTNLETLDLSNN-QLTD------LPELGNLTNLEELDLSNN------ 260

                         330       340
                  ....*....|....*....|....
gi 987943029 1337 aQATTVKSLSQcmlrLPSLTTIDM 1360
Cdd:COG4886   261 -QLTDLPPLAN----LTNLKTLDL 279
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 462-592 1.85e-05

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 46.21  E-value: 1.85e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029    462 NSVMCVEGEAGSGKTVLLKKIALLwasgccpLLNRFQLVFYLSLSSTRLDQGLANIICDQLLETEGSVTEMSLRIIMQQL 541
Cdd:smart00382    2 GEVILIVGPPGSGKTTLARALARE-------LGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALA 74

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029    542 KNQ---VLFL------LDDYKEMCSVPQVIQKLIHKNHSSRTCLLIAVrTNRTRDIRQHL 592
Cdd:smart00382   75 RKLkpdVLILdeitslLDAEQEALLLLLEELRLLLLLKSEKNLTVILT-TNDEKDLGPAL 133
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1060-1360 4.16e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 47.62  E-value: 4.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029 1060 INESELNAVEQELLLNLPSLESLEVSGTTQIPDQLFPNLDKFPCLKELSVNMDKKNVFSVIPEEFLKLHNMEKL-LIEIS 1138
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLlLLSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029 1139 AENGPSKIVKLIENSPNLNVFHLQCNffsdfesllTVLASCKKLKEIKFSGAFFKPIPFvtILTNFISLKILDL---KFQ 1215
Cdd:COG4886    81 LLSLLLLGLTDLGDLTNLTELDLSGN---------EELSNLTNLESLDLSGNQLTDLPE--ELANLTNLKELDLsnnQLT 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987943029 1216 EFPHketsekfahTLGSLSSLEELILpNGDGIHQVAKlIIQQCQHLRCLrvlsffkTLNDDSVMEIAKvAIsGGFQKLEN 1295
Cdd:COG4886   150 DLPE---------PLGNLTNLKSLDL-SNNQLTDLPE-ELGNLTNLKEL-------DLSNNQITDLPE-PL-GNLTNLEE 209

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 987943029 1296 LDLSLNhKITEegyrnFFQVLDNLPNLQELTISrhyteciRAQATTVKSLSQcmlrLPSLTTIDM 1360
Cdd:COG4886   210 LDLSGN-QLTD-----LPEPLANLTNLETLDLS-------NNQLTDLPELGN----LTNLEELDL 257
NOD2_WH pfam17779
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular ...
 688-741 3.98e-04

NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular function is not known.


Pssm-ID: 465501  Cd Length: 57  Bit Score: 39.86  E-value: 3.98e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 987943029   688 VSSCGKLALKGFFSSCFEFSDDDLVEAGVDEDeDLTMCLMSKFTAQRL--RPVYQF 741
Cdd:pfam17779    3 LLKLGKLAFEGLWKKKLVFSEEDLKEYGLDES-DLSSGLLTEILQKDLgcEKVYSF 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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