|
Name |
Accession |
Description |
Interval |
E-value |
| RssA |
COG1752 |
Predicted acylesterase/phospholipase RssA, containd patatin domain [General function ... |
59-328 |
8.76e-79 |
|
Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only];
Pssm-ID: 441358 [Multi-domain] Cd Length: 261 Bit Score: 254.44 E-value: 8.76e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 59 PDGRPAVGLVLSGGGARGYAHLGVLKVLEDNRIPIDCIAATSMGAVVGGLYASGMPAAEMQKRLSETNLADIAfdvteRA 138
Cdd:COG1752 1 APARPKIGLVLSGGGARGAAHIGVLKALEEAGIPPDVIAGTSAGAIVGALYAAGYSADELEELWRSLDRRDLF-----DL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 139 DLPQSRREderlyangATLGFSgkgvkaPAGIVQGNRLQALLADWTAavpiNQPFDKLPIPYRAIATDLQTGQMVVLDHG 218
Cdd:COG1752 76 SLPRRLLR--------LDLGLS------PGGLLDGDPLRRLLERLLG----DRDFEDLPIPLAVVATDLETGREVVFDSG 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 219 SLPLAIRASMAMPGLFAPAEINDRALVDGGLVRNLPVDSARQMGADVVIAVDIGSQLRPLDalaSPADVAQQMVGILIRQ 298
Cdd:COG1752 138 PLADAVRASAAIPGVFPPVEIDGRLYVDGGVVNNLPVDPARALGADRVIAVDLNPPLRKLP---SLLDILGRALEIMFNS 214
|
250 260 270
....*....|....*....|....*....|
gi 981772145 299 NVAAQRKqLAPQDVLLTPELGTLTFTDFQK 328
Cdd:COG1752 215 ILRRELA-LEPADILIEPDLSGISLLDFSR 243
|
|
| Pat_PNPLA6_PNPLA7_NTE1_like |
cd07205 |
Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; ... |
65-271 |
2.62e-59 |
|
Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Patatin-like phospholipase domain containing protein 6 (PNPLA6) and protein 7 (PNPLA7) are included in this family. PNPLA6 is commonly known as Neuropathy Target Esterase (NTE). NTE has at least two functional domains: the N-terminal domain putatively regulatory domain and the C-terminal catalytic domain which shows esterase activity. NTE shows phospholipase activity for lysophosphatidylcholine (LPC) and phosphatidylcholine (PC). Exposure of NTE to organophosphates leads to organophosphate-induced delayed neurotoxicity (OPIDN). OPIDN is a progressive neurological condition that is characterized by weakness, paralysis, pain, and paresthesia. PNPLA7 is an insulin-regulated phospholipase that is homologus to Neuropathy Target Esterase (NTE or PNPLA6) and is also known as NTE-related esterase (NRE). Human NRE is predominantly expressed in prostate, white adipose, and pancreatic tissue. NRE hydrolyzes sn-1 esters in lysophosphatidylcholine and lysophosphatidic acid, but shows no lipase activity with substrates like triacylglycerols (TG), cholesteryl esters, retinyl esters (RE), phosphatidylcholine (PC), or monoacylglycerol (MG). This family includes subfamily of PNPLA6 (NTE) and PNPLA7 (NRE)-like phospholipases.
Pssm-ID: 132844 [Multi-domain] Cd Length: 175 Bit Score: 198.92 E-value: 2.62e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 65 VGLVLSGGGARGYAHLGVLKVLEDNRIPIDCIAATSMGAVVGGLYASGMPAAEMQKRLSetnladiafdvteradlpqsR 144
Cdd:cd07205 1 IGLALSGGGARGLAHIGVLKALEEAGIPIDIVSGTSAGAIVGALYAAGYSPEEIEERAK--------------------L 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 145 REDERLYANGATLGFSGkgvkapagIVQGNRLQALLADWTAAVPinqpFDKLPIPYRAIATDLQTGQMVVLDHGSLPLAI 224
Cdd:cd07205 61 RSTDLKALSDLTIPTAG--------LLRGDKFLELLDEYFGDRD----IEDLWIPFFIVATDLTSGKLVVFRSGSLVRAV 128
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 981772145 225 RASMAMPGLFAPAEINDRALVDGGLVRNLPVDSARQMGADVVIAVDI 271
Cdd:cd07205 129 RASMSIPGIFPPVKIDGQLLVDGGVLNNLPVDVLRELGADIIIAVDL 175
|
|
| BamA |
COG4775 |
Outer membrane protein assembly factor BamA [Cell wall/membrane/envelope biogenesis]; |
370-796 |
7.39e-47 |
|
Outer membrane protein assembly factor BamA [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 443807 [Multi-domain] Cd Length: 711 Bit Score: 178.36 E-value: 7.39e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 370 PAIRITDIEIRTSGGVPQRVVKDALHVKPGDTYDPKAVSRDLLTLTTGGNFESV---TQQVVSNGDENRLVIDAREKYWG 446
Cdd:COG4775 310 PRVYVDRIEIEGNTRTRDEVIRRELRLKEGDPFSREKLERSRRRLYRLGYFESVdveTEPGPSTPDQVDLVVDVKEKPTG 389
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 447 PnfLLFGLGMSSSStdqgGFRLHVGYRRPWLTESGLEFRTDATVGSDLNAVHVELRQPLSVKYGDYIAPYAEYQRRYANL 526
Cdd:COG4775 390 S--LSLGAGYSSDD----GFIGGASLSQRNLLGTGQELSLSLQLGSYSQSYSLSFTEPYFFGSPLSLGVSLFYRRRDASD 463
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 527 YDDsgdvkvtqYMVQTARAGIDFGAPIGRLGDFRIGLAYTHSHGSPTYNLPLQLLDPDVTDQTallfpsysadaLSARAR 606
Cdd:COG4775 464 YSS--------YDLKRTGGGLGLGYPLSEDLRLSLGYGYERTDISDVDSSPDYLPDQNGSSNT-----------SSLGLG 524
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 607 LVIDQLDDPMFPRKGYFAEFRVERSLMSRNGasseaadsritDAPYTELYGKLMVAQQFGR-HSVSAGVEGGKSIG-GTN 684
Cdd:COG4775 525 LTYDTRDNPLFPTRGSYLSLSLEFAGPYLGG-----------DLEYYKLSADARYYFPLGKkLVLALRAEAGYLGGyGKD 593
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 685 LINAFNFTLGGFQHLAAYAADQLN----GDSLVYGQMTYMNQLATFSSSPVK-ALFVgasaEVGNVWAGGARIGGGALKQ 759
Cdd:COG4775 594 LPFFERFYLGGFGSLRGYEENSLGprlgGNAYLLGSAELRFPLPLPPSAGLRgALFV----DAGNVWDSGDDFDLSDLRY 669
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 981772145 760 SYTFFTSLTTAFGPLYMGVALA----PGGR-RNIYLQLGRTY 796
Cdd:COG4775 670 SAGVGLRWDTPLGPLRLDYAYPldkePGDSgQRFHFSIGTRF 711
|
|
| Patatin |
pfam01734 |
Patatin-like phospholipase; This family consists of various patatin glycoproteins from plants. ... |
67-258 |
3.36e-31 |
|
Patatin-like phospholipase; This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein but it also has the enzymatic activity of lipid acyl hydrolase, catalysing the cleavage of fatty acids from membrane lipids. Members of this family have been found also in vertebrates.
Pssm-ID: 396341 Cd Length: 190 Bit Score: 120.79 E-value: 3.36e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 67 LVLSGGGARGYAHLGVLKVLEDNRIPIDCIAATSMGAVVGGLYASGMPAAEMQKRLSETNLADIAFDVTERADLPQSRRe 146
Cdd:pfam01734 1 LVLSGGGARGAYHLGVLKALGEAGIRFDVISGTSAGAINAALLALGRDPEEIEDLLLELDLNLFLSLIRKRALSLLALL- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 147 deRLYANGATLgFSGKGVKAP-AGIVQGNRLQALLADWTAAVPINQPFDKLPIPYRAIATDLQTGQMVVLDHGSLPLAIR 225
Cdd:pfam01734 80 --RGLIGEGGL-FDGDALRELlRKLLGDLTLEELAARLSLLLVVALRALLTVISTALGTRARILLPDDLDDDEDLADAVL 156
|
170 180 190
....*....|....*....|....*....|...
gi 981772145 226 ASMAMPGLFAPAEINDRALVDGGLVRNLPVDSA 258
Cdd:pfam01734 157 ASSALPGVFPPVRLDGELYVDGGLVDNVPVEAA 189
|
|
| PRK10279 |
PRK10279 |
patatin-like phospholipase RssA; |
65-271 |
3.72e-30 |
|
patatin-like phospholipase RssA;
Pssm-ID: 182352 [Multi-domain] Cd Length: 300 Bit Score: 120.97 E-value: 3.72e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 65 VGLVLSGGGARGYAHLGVLKVLEDNRIPIDCIAATSMGAVVGGLYASG-MPAAEMQKRlsetnladiAF---DVTERADL 140
Cdd:PRK10279 6 IGLALGSGAARGWSHIGVINALKKVGIEIDIVAGCSIGSLVGAAYACDrLSALEDWVT---------SFsywDVLRLMDL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 141 PQSRrederlyangatlgfsgkgvkapAGIVQG----NRLQALLAdwtaavpiNQPFDKLPIPYRAIATDLQTGQMVVLD 216
Cdd:PRK10279 77 SWQR-----------------------GGLLRGervfNQYREIMP--------ETEIENCSRRFGAVATNLSTGRELWFT 125
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 981772145 217 HGSLPLAIRASMAMPGLFAPAEINDRALVDGGLVRNLPVDSARQMGADVVIAVDI 271
Cdd:PRK10279 126 EGDLHLAIRASCSMPGLMAPVAHNGYWLVDGAVVNPVPVSLTRALGADIVIAVDL 180
|
|
| Omp85 |
pfam01103 |
Omp85 superfamily domain; The Omp85 protein superfamily contains bacterial outer membrane ... |
480-774 |
2.07e-07 |
|
Omp85 superfamily domain; The Omp85 protein superfamily contains bacterial outer membrane proteins, which can function as protein translocases or as membrane protein assembly factors. The family includes the membrane bound beta barrel of proteins such as BamA and TamA from E. coli.
Pssm-ID: 460065 [Multi-domain] Cd Length: 319 Bit Score: 53.51 E-value: 2.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 480 SGLEFRTDATVGSDLNAVHVELRQPLSVKYGdYIAPYAEYQRRYANLYDDSgdvkvTQYMVQTARAGIDFGAPIGRLGDF 559
Cdd:pfam01103 5 RGQSLSVNASRGSYETSFSLSFTDPYFLGDG-VSLGGSLFYNSYDSDRDSS-----DSYRITTYGFSVSLGRPITENWSL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 560 RIGLAYTHshgsptynlpLQLLDPDVTDQTALLFPSYSADALSARARL----VIDQLDDPMFPRKGYFAEFRVERSLMSR 635
Cdd:pfam01103 79 SLGLGYQH----------NKILDESGSPNIRNYYPSASGTGKSLTFSLsygwTYDTRDDGLFPTRGSYLKFNLEFTGPFL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 636 NGASSeaadsritdapYTELYGKLMVAQQFGRHS---VSAGVEGG--KSIGGTNLINAFNFTLGGFQHLAAYA------- 703
Cdd:pfam01103 149 GGDVS-----------YYKLTADGSYYYPLGKDDsfvLSARVALGylDGYGTKDLPFYERFYAGGSNSVRGFEyggigpr 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 704 ---ADQLNGDSLVYGQMTYMNQLATFSSSPVK-ALFVGAsaevGNVW--------AGGARIGGGALKQSYTFFTSLTTAF 771
Cdd:pfam01103 218 dedGDALGGNSYVVASLELRFPLPFVPKQSVRgVLFFDA----GNVWntgstdpgSSRGARSKAGIRASVGVGLRWLSPL 293
|
...
gi 981772145 772 GPL 774
Cdd:pfam01103 294 GPL 296
|
|
| OM_YaeT |
TIGR03303 |
outer membrane protein assembly complex, YaeT protein; Members of this protein family are the ... |
388-629 |
5.07e-07 |
|
outer membrane protein assembly complex, YaeT protein; Members of this protein family are the YaeT protein of the YaeT/YfiO complex for assembling proteins into the outer membrane of Gram-negative bacteria. This protein is similar in sequence and function to a non-essential paralog, YtfM, that is also in the Omp85 family. Members of this family typically have five tandem copies of the surface antigen variable number repeat (pfam07244), followed by an outer membrane beta-barrel domain (pfam01103), while the YtfM family typically has a single pfam07244 repeat. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 274514 [Multi-domain] Cd Length: 741 Bit Score: 53.35 E-value: 5.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 388 RVVKDALHVKPGDTYDPKAVSRDLLTLTTGGNFESVTQQVVSNGDENR--LVIDAREKYWGPnfLLFGLGMSSSStdqgG 465
Cdd:TIGR03303 338 EVIRRELRQLEGDWYSLSKIKRSKRRLERLGYFETVNIETVPVGSPDQvdLNVKVKEQPTGS--ISFGVGYGSSS----G 411
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 466 FRLHVGYRRPWLTESGLEFRTDATVGSDLNAVHVELRQP------LSVKYGDYiapYAEYQRRYANLYDdsgdvkvtqYM 539
Cdd:TIGR03303 412 LSFNASISERNFLGTGNRLSLSANKSSLSTSYSLSFTDPyftddgVSLGFSIF---YSETDRNYKNFSD---------YK 479
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 540 VQTARAGIDFGAPIGRLGDFRIGLAYTHSHgsptynlplqLLDPDVTDQTALLFPSYSA---DALSARARLVIDQLDDPM 616
Cdd:TIGR03303 480 TKTYGGSINLGYPITEYLRVSLGYGYEQNK----------IKDDSDSDSSASYFIKEQGgkfIDSSLSYGWSYDTLDSGY 549
|
250
....*....|...
gi 981772145 617 FPRKGYFAEFRVE 629
Cdd:TIGR03303 550 FPTKGSIQRLSQE 562
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| RssA |
COG1752 |
Predicted acylesterase/phospholipase RssA, containd patatin domain [General function ... |
59-328 |
8.76e-79 |
|
Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only];
Pssm-ID: 441358 [Multi-domain] Cd Length: 261 Bit Score: 254.44 E-value: 8.76e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 59 PDGRPAVGLVLSGGGARGYAHLGVLKVLEDNRIPIDCIAATSMGAVVGGLYASGMPAAEMQKRLSETNLADIAfdvteRA 138
Cdd:COG1752 1 APARPKIGLVLSGGGARGAAHIGVLKALEEAGIPPDVIAGTSAGAIVGALYAAGYSADELEELWRSLDRRDLF-----DL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 139 DLPQSRREderlyangATLGFSgkgvkaPAGIVQGNRLQALLADWTAavpiNQPFDKLPIPYRAIATDLQTGQMVVLDHG 218
Cdd:COG1752 76 SLPRRLLR--------LDLGLS------PGGLLDGDPLRRLLERLLG----DRDFEDLPIPLAVVATDLETGREVVFDSG 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 219 SLPLAIRASMAMPGLFAPAEINDRALVDGGLVRNLPVDSARQMGADVVIAVDIGSQLRPLDalaSPADVAQQMVGILIRQ 298
Cdd:COG1752 138 PLADAVRASAAIPGVFPPVEIDGRLYVDGGVVNNLPVDPARALGADRVIAVDLNPPLRKLP---SLLDILGRALEIMFNS 214
|
250 260 270
....*....|....*....|....*....|
gi 981772145 299 NVAAQRKqLAPQDVLLTPELGTLTFTDFQK 328
Cdd:COG1752 215 ILRRELA-LEPADILIEPDLSGISLLDFSR 243
|
|
| Pat_PNPLA6_PNPLA7_NTE1_like |
cd07205 |
Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; ... |
65-271 |
2.62e-59 |
|
Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Patatin-like phospholipase domain containing protein 6 (PNPLA6) and protein 7 (PNPLA7) are included in this family. PNPLA6 is commonly known as Neuropathy Target Esterase (NTE). NTE has at least two functional domains: the N-terminal domain putatively regulatory domain and the C-terminal catalytic domain which shows esterase activity. NTE shows phospholipase activity for lysophosphatidylcholine (LPC) and phosphatidylcholine (PC). Exposure of NTE to organophosphates leads to organophosphate-induced delayed neurotoxicity (OPIDN). OPIDN is a progressive neurological condition that is characterized by weakness, paralysis, pain, and paresthesia. PNPLA7 is an insulin-regulated phospholipase that is homologus to Neuropathy Target Esterase (NTE or PNPLA6) and is also known as NTE-related esterase (NRE). Human NRE is predominantly expressed in prostate, white adipose, and pancreatic tissue. NRE hydrolyzes sn-1 esters in lysophosphatidylcholine and lysophosphatidic acid, but shows no lipase activity with substrates like triacylglycerols (TG), cholesteryl esters, retinyl esters (RE), phosphatidylcholine (PC), or monoacylglycerol (MG). This family includes subfamily of PNPLA6 (NTE) and PNPLA7 (NRE)-like phospholipases.
Pssm-ID: 132844 [Multi-domain] Cd Length: 175 Bit Score: 198.92 E-value: 2.62e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 65 VGLVLSGGGARGYAHLGVLKVLEDNRIPIDCIAATSMGAVVGGLYASGMPAAEMQKRLSetnladiafdvteradlpqsR 144
Cdd:cd07205 1 IGLALSGGGARGLAHIGVLKALEEAGIPIDIVSGTSAGAIVGALYAAGYSPEEIEERAK--------------------L 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 145 REDERLYANGATLGFSGkgvkapagIVQGNRLQALLADWTAAVPinqpFDKLPIPYRAIATDLQTGQMVVLDHGSLPLAI 224
Cdd:cd07205 61 RSTDLKALSDLTIPTAG--------LLRGDKFLELLDEYFGDRD----IEDLWIPFFIVATDLTSGKLVVFRSGSLVRAV 128
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 981772145 225 RASMAMPGLFAPAEINDRALVDGGLVRNLPVDSARQMGADVVIAVDI 271
Cdd:cd07205 129 RASMSIPGIFPPVKIDGQLLVDGGVLNNLPVDVLRELGADIIIAVDL 175
|
|
| Pat_NTE_like_bacteria |
cd07228 |
Bacterial patatin-like phospholipase domain containing protein 6; Bacterial patatin-like ... |
65-271 |
5.33e-57 |
|
Bacterial patatin-like phospholipase domain containing protein 6; Bacterial patatin-like phospholipase domain containing protein 6. PNPLA6 is commonly known as Neuropathy Target Esterase (NTE). NTE has at least two functional domains: the N-terminal domain putatively regulatory domain and the C-terminal catalytic domain which shows esterase activity. NTE shows phospholipase activity for lysophosphatidylcholine (LPC) and phosphatidylcholine (PC). Exposure of NTE to organophosphates leads to organophosphate-induced delayed neurotoxicity (OPIDN). OPIDN is a progressive neurological condition that is characterized by weakness, paralysis, pain, and paresthesia. This group includes YCHK and rssA from Escherichia coli as well as Ylbk from Bacillus amyloliquefaciens.
Pssm-ID: 132866 [Multi-domain] Cd Length: 175 Bit Score: 192.49 E-value: 5.33e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 65 VGLVLSGGGARGYAHLGVLKVLEDNRIPIDCIAATSMGAVVGGLYASGMPAAEMQKRLSETnladiAFDVTERADLPQSR 144
Cdd:cd07228 1 IGLALGSGGARGWAHIGVLRALEEEGIEIDIIAGSSIGALVGALYAAGHLDALEEWVRSLS-----QRDVLRLLDLSASR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 145 rederlyangatlgfsgkgvkapAGIVQGNRLQALLADWTAAVPinqpFDKLPIPYRAIATDLQTGQMVVLDHGSLPLAI 224
Cdd:cd07228 76 -----------------------SGLLKGEKVLEYLREIMGGVT----IEELPIPFAAVATDLQTGKEVWFREGSLIDAI 128
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 981772145 225 RASMAMPGLFAPAEINDRALVDGGLVRNLPVDSARQMGADVVIAVDI 271
Cdd:cd07228 129 RASISIPGIFAPVEHNGRLLVDGGVVNPIPVSVARALGADIVIAVDL 175
|
|
| BamA |
COG4775 |
Outer membrane protein assembly factor BamA [Cell wall/membrane/envelope biogenesis]; |
370-796 |
7.39e-47 |
|
Outer membrane protein assembly factor BamA [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 443807 [Multi-domain] Cd Length: 711 Bit Score: 178.36 E-value: 7.39e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 370 PAIRITDIEIRTSGGVPQRVVKDALHVKPGDTYDPKAVSRDLLTLTTGGNFESV---TQQVVSNGDENRLVIDAREKYWG 446
Cdd:COG4775 310 PRVYVDRIEIEGNTRTRDEVIRRELRLKEGDPFSREKLERSRRRLYRLGYFESVdveTEPGPSTPDQVDLVVDVKEKPTG 389
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 447 PnfLLFGLGMSSSStdqgGFRLHVGYRRPWLTESGLEFRTDATVGSDLNAVHVELRQPLSVKYGDYIAPYAEYQRRYANL 526
Cdd:COG4775 390 S--LSLGAGYSSDD----GFIGGASLSQRNLLGTGQELSLSLQLGSYSQSYSLSFTEPYFFGSPLSLGVSLFYRRRDASD 463
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 527 YDDsgdvkvtqYMVQTARAGIDFGAPIGRLGDFRIGLAYTHSHGSPTYNLPLQLLDPDVTDQTallfpsysadaLSARAR 606
Cdd:COG4775 464 YSS--------YDLKRTGGGLGLGYPLSEDLRLSLGYGYERTDISDVDSSPDYLPDQNGSSNT-----------SSLGLG 524
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 607 LVIDQLDDPMFPRKGYFAEFRVERSLMSRNGasseaadsritDAPYTELYGKLMVAQQFGR-HSVSAGVEGGKSIG-GTN 684
Cdd:COG4775 525 LTYDTRDNPLFPTRGSYLSLSLEFAGPYLGG-----------DLEYYKLSADARYYFPLGKkLVLALRAEAGYLGGyGKD 593
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 685 LINAFNFTLGGFQHLAAYAADQLN----GDSLVYGQMTYMNQLATFSSSPVK-ALFVgasaEVGNVWAGGARIGGGALKQ 759
Cdd:COG4775 594 LPFFERFYLGGFGSLRGYEENSLGprlgGNAYLLGSAELRFPLPLPPSAGLRgALFV----DAGNVWDSGDDFDLSDLRY 669
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 981772145 760 SYTFFTSLTTAFGPLYMGVALA----PGGR-RNIYLQLGRTY 796
Cdd:COG4775 670 SAGVGLRWDTPLGPLRLDYAYPldkePGDSgQRFHFSIGTRF 711
|
|
| Pat_PNPLA6_PNPLA7 |
cd07225 |
Patatin-like phospholipase domain containing protein 6 and protein 7; Patatin-like ... |
64-275 |
1.13e-35 |
|
Patatin-like phospholipase domain containing protein 6 and protein 7; Patatin-like phospholipase domain containing protein 6 (PNPLA6) and protein 7 (PNPLA7) are 60% identical to each other. PNPLA6 is commonly known as Neuropathy Target Esterase (NTE). NTE has at least two functional domains: the N-terminal domain putatively regulatory domain and the C-terminal catalytic domain which shows esterase activity. NTE shows phospholipase activity for lysophosphatidylcholine (LPC) and phosphatidylcholine (PC). Exposure of NTE to organophosphates leads to organophosphate-induced delayed neurotoxicity (OPIDN). OPIDN is a progressive neurological condition that is characterized by weakness, paralysis, pain, and paresthesia. PNPLA7 is an insulin-regulated phospholipase that is homologous to Neuropathy Target Esterase (NTE or PNPLA6) and is also known as NTE-related esterase (NRE). Human NRE is predominantly expressed in prostate, white adipose, and pancreatic tissue. NRE hydrolyzes sn-1 esters in lysophosphatidylcholine and lysophosphatidic acid, but shows no lipase activity with substrates like triacylglycerols (TG), cholesteryl esters, retinyl esters (RE), phosphatidylcholine (PC), or monoacylglycerol (MG). This family includes PNPLA6 and PNPLA7 from Homo sapiens, YMF9 from Yeast, and Swiss Cheese protein (sws) from Drosophila melanogaster.
Pssm-ID: 132864 [Multi-domain] Cd Length: 306 Bit Score: 137.15 E-value: 1.13e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 64 AVGLVLSGGGARGYAHLGVLKVLEDNRIPIDCIAATSMGAVVGGLYASGMPAAEMQKRLSE-----TNLADIAFDVTera 138
Cdd:cd07225 15 SIALVLGGGGARGCAHIGVIKALEEAGIPVDMVGGTSIGAFIGALYAEERNISRMKQRAREwakdmTSIWKKLLDLT--- 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 139 dlpqsrrederlYAngATLGFSGKGVKAPAGIVQGNRLqalladwtaavpinqpFDKLPIPYRAIATDLQTGQMVVLDHG 218
Cdd:cd07225 92 ------------YP--ITSMFSGAAFNRSIHSIFGDKQ----------------IEDLWLPYFTITTDITASAMRVHTDG 141
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 981772145 219 SLPLAIRASMAMPGLFAPaeIND----RALVDGGLVRNLPVDSARQMGADVVIAVDIGSQL 275
Cdd:cd07225 142 SLWRYVRASMSLSGYLPP--LCDpkdgHLLMDGGYINNLPADVARSMGAKTVIAIDVGSQD 200
|
|
| Pat_hypo_W_succinogenes_WS1459_like |
cd07210 |
Hypothetical patatin similar to WS1459 of Wolinella succinogenes; Patatin-like phospholipase. ... |
65-259 |
3.24e-34 |
|
Hypothetical patatin similar to WS1459 of Wolinella succinogenes; Patatin-like phospholipase. This family predominantly consists of bacterial patatin glycoproteins. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates.
Pssm-ID: 132849 [Multi-domain] Cd Length: 221 Bit Score: 130.54 E-value: 3.24e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 65 VGLVLSGGGARGYAHLGVLKVLEDNRIPIDCIAATSMGAVVGGLYASGMPAAEMQKRLSETNLADIafdvteradlpqsr 144
Cdd:cd07210 1 FALVLSSGFFGFYAHLGFLAALLEMGLEPSAISGTSAGALVGGLFASGISPDEMAELLLSLERKDF-------------- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 145 rederlyangatLGFSGKGVKApaGIVQGNRLQALLADwtaAVPInQPFDKLPIPYRAIATDLQTGQMVVLDHGSLPLAI 224
Cdd:cd07210 67 ------------WMFWDPPLRG--GLLSGDRFAALLRE---HLPP-DRFEELRIPLAVSVVDLTSRETLLLSEGDLAEAV 128
|
170 180 190
....*....|....*....|....*....|....*
gi 981772145 225 RASMAMPGLFAPAEINDRALVDGGLVRNLPVDSAR 259
Cdd:cd07210 129 AASCAVPPLFQPVEIGGRPFVDGGVADRLPFDALR 163
|
|
| Pat_ExoU_VipD_like |
cd07207 |
ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; ExoU, a 74-kDa enzyme, is ... |
67-256 |
4.73e-32 |
|
ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; ExoU, a 74-kDa enzyme, is a potent virulence factor of Pseudomonas aeruginosa. One of the pathogenic mechanisms of P. aeruginosa is to induce cytotoxicity by the injection of effector proteins (e.g. ExoU) using the type III secretion (T3S) system. ExoU is homologus to patatin and also has the conserved catalytic residues of mammalian calcium-independent (iPLA2) and cytosolic (cPLA2) PLA2. In vitro, ExoU cytotoxity is blocked by the inhibitor of cytosolic and Ca2-independent phospholipase A2 (cPLA2 and iPLA2) enzymes, suggesting that phospholipase A2 inhibitors may represent a novel mode of treatment for acute P. aeruginosa infections. ExoU requires eukaryotic superoxide dismutase as a cofactor and cleaves phosphatidylcholine and phosphatidylethanolamine in vitro. VipD, a 69-kDa cytosolic protein, belongs to the members of Legionella pneumophila family and is homologus to ExoU from Pseudomonas. Even though VipD shows high sequence similarity with several functional regions of ExoU (e.g. oxyanion hole, active site serine, active site aspartate), it has been shown to have no phospholipase activity. This family includes ExoU from Pseudomonas aeruginosa and VipD of Legionella pneumophila.
Pssm-ID: 132846 Cd Length: 194 Bit Score: 123.16 E-value: 4.73e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 67 LVLSGGGARGYAHLGVLKVLEDNRIPIDCIAATSMGAVVGGLYASGMPAAEMQKRLSETNLADiafdvteradlpqsrre 146
Cdd:cd07207 2 LVFEGGGAKGIAYIGALKALEEAGILKKRVAGTSAGAITAALLALGYSAADIKDILKETDFAK----------------- 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 147 derLYANGATLGFSGKGVKAPAGIVQGNRLQALLADWTAAVPIN--------QPFDKLPIPYRAIATDLQTGQMVVLDHG 218
Cdd:cd07207 65 ---LLDSPVGLLFLLPSLFKEGGLYKGDALEEWLRELLKEKTGNsfatsllrDLDDDLGKDLKVVATDLTTGALVVFSAE 141
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 981772145 219 SLP-----LAIRASMAMPGLFAPAEiNDRA--LVDGGLVRNLPVD 256
Cdd:cd07207 142 TTPdmpvaKAVRASMSIPFVFKPVR-LAKGdvYVDGGVLDNYPVW 185
|
|
| Patatin |
pfam01734 |
Patatin-like phospholipase; This family consists of various patatin glycoproteins from plants. ... |
67-258 |
3.36e-31 |
|
Patatin-like phospholipase; This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein but it also has the enzymatic activity of lipid acyl hydrolase, catalysing the cleavage of fatty acids from membrane lipids. Members of this family have been found also in vertebrates.
Pssm-ID: 396341 Cd Length: 190 Bit Score: 120.79 E-value: 3.36e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 67 LVLSGGGARGYAHLGVLKVLEDNRIPIDCIAATSMGAVVGGLYASGMPAAEMQKRLSETNLADIAFDVTERADLPQSRRe 146
Cdd:pfam01734 1 LVLSGGGARGAYHLGVLKALGEAGIRFDVISGTSAGAINAALLALGRDPEEIEDLLLELDLNLFLSLIRKRALSLLALL- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 147 deRLYANGATLgFSGKGVKAP-AGIVQGNRLQALLADWTAAVPINQPFDKLPIPYRAIATDLQTGQMVVLDHGSLPLAIR 225
Cdd:pfam01734 80 --RGLIGEGGL-FDGDALRELlRKLLGDLTLEELAARLSLLLVVALRALLTVISTALGTRARILLPDDLDDDEDLADAVL 156
|
170 180 190
....*....|....*....|....*....|...
gi 981772145 226 ASMAMPGLFAPAEINDRALVDGGLVRNLPVDSA 258
Cdd:pfam01734 157 ASSALPGVFPPVRLDGELYVDGGLVDNVPVEAA 189
|
|
| PRK10279 |
PRK10279 |
patatin-like phospholipase RssA; |
65-271 |
3.72e-30 |
|
patatin-like phospholipase RssA;
Pssm-ID: 182352 [Multi-domain] Cd Length: 300 Bit Score: 120.97 E-value: 3.72e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 65 VGLVLSGGGARGYAHLGVLKVLEDNRIPIDCIAATSMGAVVGGLYASG-MPAAEMQKRlsetnladiAF---DVTERADL 140
Cdd:PRK10279 6 IGLALGSGAARGWSHIGVINALKKVGIEIDIVAGCSIGSLVGAAYACDrLSALEDWVT---------SFsywDVLRLMDL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 141 PQSRrederlyangatlgfsgkgvkapAGIVQG----NRLQALLAdwtaavpiNQPFDKLPIPYRAIATDLQTGQMVVLD 216
Cdd:PRK10279 77 SWQR-----------------------GGLLRGervfNQYREIMP--------ETEIENCSRRFGAVATNLSTGRELWFT 125
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 981772145 217 HGSLPLAIRASMAMPGLFAPAEINDRALVDGGLVRNLPVDSARQMGADVVIAVDI 271
Cdd:PRK10279 126 EGDLHLAIRASCSMPGLMAPVAHNGYWLVDGAVVNPVPVSLTRALGADIVIAVDL 180
|
|
| Pat_Fungal_NTE1 |
cd07227 |
Fungal patatin-like phospholipase domain containing protein 6; These are fungal Neuropathy ... |
64-273 |
1.72e-27 |
|
Fungal patatin-like phospholipase domain containing protein 6; These are fungal Neuropathy Target Esterase (NTE), commonly referred to as NTE1. Patatin-like phospholipase. NTE has at least two functional domains: the N-terminal domain putatively regulatory domain and the C-terminal catalytic domain which shows esterase activity. NTE shows phospholipase activity for lysophosphatidylcholine (LPC) and phosphatidylcholine (PC). Exposure of NTE to organophosphates leads to organophosphate-induced delayed neurotoxicity (OPIDN). OPIDN is a progressive neurological condition that is characterized by weakness, paralysis, pain, and paresthesia. This family includes NTE1 from fungi.
Pssm-ID: 132865 [Multi-domain] Cd Length: 269 Bit Score: 112.59 E-value: 1.72e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 64 AVGLVLSGGGARGYAHLGVLKVLEDNRIPIDCIAATSMGAVVGGLYASGMPAAEMQKRLSE-----TNLADIAFDVTera 138
Cdd:cd07227 10 AIGLVLGGGGARGISHIGILQALEEAGIPIDAIGGTSIGSFVGGLYAREADLVPIFGRAKKfagrmASMWRFLSDVT--- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 139 dLPQSRrederlYANGATLgfsGKGVKAPAGIVQgnrlqalLAD-WtaavpinqpfdklpIPYRAIATDLQTGQMVVLDH 217
Cdd:cd07227 87 -YPFAS------YTTGHEF---NRGIWKTFGNTH-------IEDfW--------------IPFYANSTNITHSRMEIHSS 135
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 981772145 218 GSLPLAIRASMAMPGLFAPAEINDRALVDGGLVRNLPVDSARQMGADVVIAVDIGS 273
Cdd:cd07227 136 GYAWRYIRASMSLAGLLPPLSDNGSMLLDGGYMDNLPVSPMRSLGIRDIFAVDVGS 191
|
|
| Pat_hypo_Ecoli_Z1214_like |
cd07209 |
Hypothetical patatin similar to Z1214 protein of Escherichia coli; Patatin-like phospholipase ... |
67-287 |
5.45e-27 |
|
Hypothetical patatin similar to Z1214 protein of Escherichia coli; Patatin-like phospholipase similar to Z1214 protein of Escherichia coli. This family predominantly consists of bacterial patatin glycoproteins and some representatives from eukaryotes and archaea. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates.
Pssm-ID: 132848 [Multi-domain] Cd Length: 215 Bit Score: 109.30 E-value: 5.45e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 67 LVLSGGGARGYAHLGVLKVLEDNRIPIDCIAATSMGAVVGGLYASGMPaaEMQKRLsetnladiafdvteradlpqsrre 146
Cdd:cd07209 1 LVLSGGGALGAYQAGVLKALAEAGIEPDIISGTSIGAINGALIAGGDP--EAVERL------------------------ 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 147 dERLYangatlgfsgKGVKAPAGIVQGNRLQALLADWTAAVPInqPFDKLPIpyraIATDLQTGQMVVLD---HGSLPLA 223
Cdd:cd07209 55 -EKLW----------RELSREDVFLRGLLDRALDFDTLRLLAI--LFAGLVI----VAVNVLTGEPVYFDdipDGILPEH 117
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 981772145 224 IRASMAMPGLFAPAEINDRALVDGGLVRNLPVDSARQMGADVVIAVDIGSQLRPLDALASPADV 287
Cdd:cd07209 118 LLASAALPPFFPPVEIDGRYYWDGGVVDNTPLSPAIDLGADEIIVVSLSDKGRDDRKGTPPTTL 181
|
|
| Patatin |
cd07198 |
Patatin-like phospholipase; Patatin is a storage protein of the potato tuber that shows ... |
67-269 |
4.61e-24 |
|
Patatin-like phospholipase; Patatin is a storage protein of the potato tuber that shows Phospholipase A2 activity (PLA2; EC 3.1.1.4). Patatin catalyzes the nonspecific hydrolysis of phospholipids, glycolipids, sulfolipids, and mono- and diacylglycerols, thereby showing lipid acyl hydrolase activity. The active site includes an oxyanion hole with a conserved GGxR motif; it is found in almost all the members of this family. The catalytic dyad is formed by a serine and an aspartate. Patatin belongs to the alpha-beta hydrolase family which is identified by a characteristic nucleophile elbow with a consensus sequence of Sm-X-Nu-Sm (Sm = small residue, X = any residue and Nu = nucleophile). Members of this family have been found also in vertebrates. This family includes PNPLA (1-9), TGL (3-5), ExoU-like, and SDP1-like subfamilies. There are some additional hypothetical proteins included in this family.
Pssm-ID: 132837 [Multi-domain] Cd Length: 172 Bit Score: 99.72 E-value: 4.61e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 67 LVLSGGGARGYAHLGVLKVLEDNRIPIDCIAATSMGAVVGGLYASGMPAAEMQKRLSETNLAdiafdvteradlpQSRRE 146
Cdd:cd07198 1 LVLSGGGALGIYHVGVAKALRERGPLIDIIAGTSAGAIVAALLASGRDLEEALLLLLRLSRE-------------VRLRF 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 147 DERLYANGATLgfsgkgvkapagivqGNRLQALLADWTAAVPINQpfdklPIPYRAIATDLQTGQMVVLDH---GSLPLA 223
Cdd:cd07198 68 DGAFPPTGRLL---------------GILRQPLLSALPDDAHEDA-----SGKLFISLTRLTDGENVLVSDtskGELWSA 127
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 981772145 224 IRASMAMPGLFAP--AEINDRALVDGGLVRNLPVDSarqMGADVVIAV 269
Cdd:cd07198 128 VRASSSIPGYFGPvpLSFRGRRYGDGGLSNNLPVAE---LGNTINVSP 172
|
|
| YjjU |
COG4667 |
Predicted phospholipase, patatin/cPLA2 family [Lipid transport and metabolism]; |
65-269 |
3.64e-18 |
|
Predicted phospholipase, patatin/cPLA2 family [Lipid transport and metabolism];
Pssm-ID: 443704 [Multi-domain] Cd Length: 281 Bit Score: 85.60 E-value: 3.64e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 65 VGLVLSGGGARG-YAHlGVLKVLEDNRIPIDCIAATSMGAVVGGLYASGmpaaemQKRLSETNLADIAFDvteradlPQ- 142
Cdd:COG4667 6 TALVLEGGGMRGiFTA-GVLDALLEEGIPFDLVIGVSAGALNGASYLSR------QPGRARRVITDYATD-------PRf 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 143 -SRRedeRLYANGATLGfsgkgvkapagivqgnrlqallADW------TAAVPINQP-FDKLPIPYRAIATDLQTGQMVV 214
Cdd:COG4667 72 fSLR---NFLRGGNLFD----------------------LDFlydeipNELLPFDFEtFKASPREFYVVATNADTGEAEY 126
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 981772145 215 L----DHGSLPLAIRASMAMPGLFAPAEINDRALVDGGLVRNLPVDSARQMGADVVIAV 269
Cdd:COG4667 127 FskkdDDYDLLDALRASSALPLLYPPVEIDGKRYLDGGVADSIPVREAIRDGADKIVVI 185
|
|
| TamA |
COG0729 |
Outer membrane translocation and assembly module TamA [Cell wall/membrane/envelope biogenesis]; ... |
370-681 |
9.00e-18 |
|
Outer membrane translocation and assembly module TamA [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440493 [Multi-domain] Cd Length: 574 Bit Score: 87.64 E-value: 9.00e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 370 PAIRITDIEIRTSGGVPQRVVKDALHVKPGDTYDPKAVSRDLLTLTTGGNFESVTQQVVSNGDENR---LVIDAREKywG 446
Cdd:COG0729 185 PRYRFGEITVEGLSRVPEDFLRRLAPFKPGEPYSPDKLLELQQRLQSTGYFSSVRVTPDEDPAPDGtvpVTVTLTER--K 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 447 PNFLLFGLGMSsssTDQGgFRLHVGYRRPWLTESGLEFRTDATVGSDLNAVHVELRQPLSVKYGDYIAPYAEYQRryanl 526
Cdd:COG0729 263 RRRIGFGLGYS---TDTG-PRLSAGWEHRNLFGRGHRLRLELELSQPEQSLSADYRIPPLFPLGQYLSLGAGLER----- 333
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 527 yDDSGDVKVTqymvqTARAGIDFGAPIGRLGDFRIGLAYTHSHgsptynlplqLLDPDVTDQTALLFPSYSadalsarar 606
Cdd:COG0729 334 -EDTDDYDSR-----SLTLGAGRTRRLSDGWTRSLGLRLLYER----------FTDGDDDRTYTLLSPGLS--------- 388
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 981772145 607 LVIDQLDDPMFPRKGYFAEFRVErslmsrngASSEAADSritDAPYTELYGKLMVAQQFGRHSVSAG-VEGGKSIG 681
Cdd:COG0729 389 WTRDRRDDPLDPTRGYRLSLELG--------PGSKLLGS---DTSFLRLYARGSWYRPLGERHRLAGrAELGAILG 453
|
|
| Pat_hypo_Ecoli_yjju_like |
cd07208 |
Hypothetical patatin similar to yjju protein of Escherichia coli; Patatin-like phospholipase ... |
67-267 |
4.30e-15 |
|
Hypothetical patatin similar to yjju protein of Escherichia coli; Patatin-like phospholipase similar to yjju protein of Escherichia coli. This family predominantly consists of bacterial patatin glycoproteins, and some representatives from eukaryotes and archaea. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates.
Pssm-ID: 132847 [Multi-domain] Cd Length: 266 Bit Score: 76.11 E-value: 4.30e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 67 LVLSGGGARG-YAhLGVLKVLEDNRI-PIDCIAATSMGAVVGGLYASGMpaaemQKRLSETNLadiafdvteraDLPQSR 144
Cdd:cd07208 1 LVLEGGGMRGaYT-AGVLDAFLEAGIrPFDLVIGVSAGALNAASYLSGQ-----RGRALRINT-----------KYATDP 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 145 RederlYANGATLgFSGKGvkapagIVQGNRLQALLADwtaavpINQPFD-----KLPIPYRAIATDLQTGQMVVLDHGS 219
Cdd:cd07208 64 R-----YLGLRSL-LRTGN------LFDLDFLYDELPD------GLDPFDfeafaASPARFYVVATDADTGEAVYFDKPD 125
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 981772145 220 LP----LAIRASMAMPGLFAPAEINDRALVDGGLVRNLPVDSARQMGAD--VVI 267
Cdd:cd07208 126 ILddllDALRASSALPGLFPPVRIDGEPYVDGGLSDSIPVDKAIEDGADkiVVI 179
|
|
| Omp85 |
pfam01103 |
Omp85 superfamily domain; The Omp85 protein superfamily contains bacterial outer membrane ... |
480-774 |
2.07e-07 |
|
Omp85 superfamily domain; The Omp85 protein superfamily contains bacterial outer membrane proteins, which can function as protein translocases or as membrane protein assembly factors. The family includes the membrane bound beta barrel of proteins such as BamA and TamA from E. coli.
Pssm-ID: 460065 [Multi-domain] Cd Length: 319 Bit Score: 53.51 E-value: 2.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 480 SGLEFRTDATVGSDLNAVHVELRQPLSVKYGdYIAPYAEYQRRYANLYDDSgdvkvTQYMVQTARAGIDFGAPIGRLGDF 559
Cdd:pfam01103 5 RGQSLSVNASRGSYETSFSLSFTDPYFLGDG-VSLGGSLFYNSYDSDRDSS-----DSYRITTYGFSVSLGRPITENWSL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 560 RIGLAYTHshgsptynlpLQLLDPDVTDQTALLFPSYSADALSARARL----VIDQLDDPMFPRKGYFAEFRVERSLMSR 635
Cdd:pfam01103 79 SLGLGYQH----------NKILDESGSPNIRNYYPSASGTGKSLTFSLsygwTYDTRDDGLFPTRGSYLKFNLEFTGPFL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 636 NGASSeaadsritdapYTELYGKLMVAQQFGRHS---VSAGVEGG--KSIGGTNLINAFNFTLGGFQHLAAYA------- 703
Cdd:pfam01103 149 GGDVS-----------YYKLTADGSYYYPLGKDDsfvLSARVALGylDGYGTKDLPFYERFYAGGSNSVRGFEyggigpr 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 704 ---ADQLNGDSLVYGQMTYMNQLATFSSSPVK-ALFVGAsaevGNVW--------AGGARIGGGALKQSYTFFTSLTTAF 771
Cdd:pfam01103 218 dedGDALGGNSYVVASLELRFPLPFVPKQSVRgVLFFDA----GNVWntgstdpgSSRGARSKAGIRASVGVGLRWLSPL 293
|
...
gi 981772145 772 GPL 774
Cdd:pfam01103 294 GPL 296
|
|
| OM_YaeT |
TIGR03303 |
outer membrane protein assembly complex, YaeT protein; Members of this protein family are the ... |
388-629 |
5.07e-07 |
|
outer membrane protein assembly complex, YaeT protein; Members of this protein family are the YaeT protein of the YaeT/YfiO complex for assembling proteins into the outer membrane of Gram-negative bacteria. This protein is similar in sequence and function to a non-essential paralog, YtfM, that is also in the Omp85 family. Members of this family typically have five tandem copies of the surface antigen variable number repeat (pfam07244), followed by an outer membrane beta-barrel domain (pfam01103), while the YtfM family typically has a single pfam07244 repeat. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 274514 [Multi-domain] Cd Length: 741 Bit Score: 53.35 E-value: 5.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 388 RVVKDALHVKPGDTYDPKAVSRDLLTLTTGGNFESVTQQVVSNGDENR--LVIDAREKYWGPnfLLFGLGMSSSStdqgG 465
Cdd:TIGR03303 338 EVIRRELRQLEGDWYSLSKIKRSKRRLERLGYFETVNIETVPVGSPDQvdLNVKVKEQPTGS--ISFGVGYGSSS----G 411
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 466 FRLHVGYRRPWLTESGLEFRTDATVGSDLNAVHVELRQP------LSVKYGDYiapYAEYQRRYANLYDdsgdvkvtqYM 539
Cdd:TIGR03303 412 LSFNASISERNFLGTGNRLSLSANKSSLSTSYSLSFTDPyftddgVSLGFSIF---YSETDRNYKNFSD---------YK 479
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 540 VQTARAGIDFGAPIGRLGDFRIGLAYTHSHgsptynlplqLLDPDVTDQTALLFPSYSA---DALSARARLVIDQLDDPM 616
Cdd:TIGR03303 480 TKTYGGSINLGYPITEYLRVSLGYGYEQNK----------IKDDSDSDSSASYFIKEQGgkfIDSSLSYGWSYDTLDSGY 549
|
250
....*....|...
gi 981772145 617 FPRKGYFAEFRVE 629
Cdd:TIGR03303 550 FPTKGSIQRLSQE 562
|
|
| Pat_PLPL |
cd07232 |
Patain-like phospholipase; Patatin-like phospholipase. This family consists of various patatin ... |
61-110 |
5.84e-07 |
|
Patain-like phospholipase; Patatin-like phospholipase. This family consists of various patatin glycoproteins from plants and fungi. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have been found also in vertebrates.
Pssm-ID: 132870 Cd Length: 407 Bit Score: 52.65 E-value: 5.84e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 981772145 61 GRPAvgLVLSGGGARGYAHLGVLKVLEDNRIPIDCIAATSMGAVVGGLYA 110
Cdd:cd07232 66 GRTA--LCLSGGAAFAYYHFGVVKALLDADLLPNVISGTSGGSLVAALLC 113
|
|
| Pat_TGL3-4-5_SDP1 |
cd07206 |
Triacylglycerol lipase 3, 4, and 5 and Sugar-Dependent 1 lipase; Triacylglycerol lipases are ... |
61-111 |
1.31e-05 |
|
Triacylglycerol lipase 3, 4, and 5 and Sugar-Dependent 1 lipase; Triacylglycerol lipases are involved in triacylglycerol mobilization and degradation; they are found in lipid particles. TGL4 is 30% homologus to TGL3, whereas TGL5 is 26% homologus to TGL3. Sugar-Dependent 1 (SDP1) lipase has a patatin-like acyl-hydrolase domain that initiates the breakdown of storage oil in germinating Arabidopsis seeds. This family includes subfamilies of proteins: TGL3, TGL4, TGL5, and SDP1.
Pssm-ID: 132845 Cd Length: 298 Bit Score: 47.98 E-value: 1.31e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 981772145 61 GRPAvgLVLSGGGARGYAHLGVLKVL-EDNRIPiDCIAATSMGAVVGGLYAS 111
Cdd:cd07206 68 GRTA--LMLSGGASLGLFHLGVVKALwEQDLLP-RVISGSSAGAIVAALLGT 116
|
|
| Pat17_PNPLA8_PNPLA9_like |
cd07199 |
Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Patatin is a storage protein ... |
67-260 |
2.34e-05 |
|
Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Patatin is a storage protein of the potato tuber that shows Phospholipase A2 activity (PLA2; EC 3.1.1.4). Patatin catalyzes the nonspecific hydrolysis of phospholipids, glycolipids, sulfolipids, and mono- and diacylglycerols, thereby showing lipid acyl hydrolase activity. The active site includes an oxyanion hole with a conserved GGxR motif; it is found in almost all the members of this family. The catalytic dyad is formed by a serine and an aspartate. Patatin belongs to the alpha-beta hydrolase family which is identified by a characteristic nucleophile elbow with a consensus sequence of Sm-X-Nu-Sm (Sm = small residue, X = any residue and Nu = nucleophile). Members of this family have been found also in vertebrates. This family includes subfamily of PNPLA8 (iPLA2-gamma) and PNPLA9 (iPLA2-beta) like phospholipases from human as well as the Pat17 isozyme from Solanum cardiophyllum.
Pssm-ID: 132838 [Multi-domain] Cd Length: 258 Bit Score: 46.56 E-value: 2.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 67 LVLSGGGARGYAHLGVLKVLED---NRIPI----DCIAATSMGAVVG-GLYASGMPAAEMqKRLSETNLADIafdvtera 138
Cdd:cd07199 2 LSLDGGGIRGIIPAEILAELEKrlgKPSRIadlfDLIAGTSTGGIIAlGLALGRYSAEEL-VELYEELGRKI-------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 139 dlpqsrrederlyangatlgfsgkgvkapagivqgnrlqalladwtaavpinqpFDKLPIPyraiATDLQTGQMVVL--- 215
Cdd:cd07199 73 ------------------------------------------------------FPRVLVT----AYDLSTGKPVVFsny 94
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 981772145 216 ------DHGSLPL--AIRASMAMPGLFAPAEI----NDRALVDGGLVRNLPVDSARQ 260
Cdd:cd07199 95 daeepdDDDDFKLwdVARATSAAPTYFPPAVIesggDEGAFVDGGVAANNPALLALA 151
|
|
| Omp85_2 |
pfam19143 |
OMP85 superfamily; This entry represents the membrane spanning beta barrel domain of various ... |
601-713 |
4.26e-05 |
|
OMP85 superfamily; This entry represents the membrane spanning beta barrel domain of various Omp85 superfamily related proteins that have often have POTRA and Patatin domains. This family contains mainly flavobacterial proteins.
Pssm-ID: 465981 Cd Length: 351 Bit Score: 46.69 E-value: 4.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 601 LSARARLVIDQLDDPMFPRKGYFAEFRVERSLMSrngasseaadSRITD--APYTELYGKLMVAQQFGRH-SVSAGVEGG 677
Cdd:pfam19143 159 FSAFGYLKLDTYDNKYFPTKGFYFDGDFHWYLFS----------SDYNNdfEEFSIAKADIGYAFTFFDKlSFNLETEGG 228
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 981772145 678 KSIGGTNlINAFNFTLGG--------FQHLAAYAADQLNGDSLV 713
Cdd:pfam19143 229 FKIGNSS-VPSFDFVLGGygnnfinnFIPFYGYDFLSLSGNSYV 271
|
|
| POTRA |
pfam07244 |
Surface antigen variable number repeat; This family is found primarily in bacterial surface ... |
373-443 |
1.71e-04 |
|
Surface antigen variable number repeat; This family is found primarily in bacterial surface antigens, normally as variable number repeats at the N-terminus. The C-terminus of these proteins is normally represented by pfam01103. The alignment centres on a -GY- or -GF- motif. Some members of this family are found in the mitochondria. It is predicted to have a mixed alpha/beta secondary structure.
Pssm-ID: 462121 [Multi-domain] Cd Length: 78 Bit Score: 40.79 E-value: 1.71e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 981772145 373 RITDIEIRTSGGVPQRVVKDALHVKPGDTYDPKAVSRDLLTLT-----TGGNFESVTQQVVSNGDENR--LVIDAREK 443
Cdd:pfam07244 1 KIGDINFEGNKKTKDEELRRLLGLKEGDVYNREKLEEDKEALKdrygrLGYFDASVSTNVEIDDEVNTvdLTFNVDEG 78
|
|
| Pat_SDP1-like |
cd07231 |
Sugar-Dependent 1 like lipase; Sugar-Dependent 1 (SDP1) lipase has a patatin-like ... |
61-111 |
2.42e-04 |
|
Sugar-Dependent 1 like lipase; Sugar-Dependent 1 (SDP1) lipase has a patatin-like acyl-hydrolase domain that initiates the breakdown of storage oil in germinating Arabidopsis seeds. This acyl-hydrolase domain is homologus to yeast triacylglycerol lipase 3 and human adipose triglyceride lipase. This family includes SDP1 from Arabidopsis thaliana.
Pssm-ID: 132869 Cd Length: 323 Bit Score: 43.98 E-value: 2.42e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 981772145 61 GRPAvgLVLSGGGARGYAHLGVLKVLEDNRIPIDCIAATSMGAVVGGLYAS 111
Cdd:cd07231 67 GRTA--LLLSGGAALGTFHVGVVRTLVEHQLLPRVIAGSSVGSIVCAIIAT 115
|
|
| Patatin_and_cPLA2 |
cd01819 |
Patatins and Phospholipases; Patatin-like phospholipase. This family consists of various ... |
67-111 |
4.35e-04 |
|
Patatins and Phospholipases; Patatin-like phospholipase. This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates. This family also includes the catalytic domain of cytosolic phospholipase A2 (PLA2; EC 3.1.1.4) hydrolyzes the sn-2-acyl ester bond of phospholipids to release arachidonic acid. At the active site, cPLA2 contains a serine nucleophile through which the catalytic mechanism is initiated. The active site is partially covered by a solvent-accessible flexible lid. cPLA2 displays interfacial activation as it exists in both "closed lid" and "open lid" forms.
Pssm-ID: 132836 [Multi-domain] Cd Length: 155 Bit Score: 41.63 E-value: 4.35e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 981772145 67 LVLSGGGARGYAHLGVLKVLeDNRIPIDC---IAATSMGAVVGGLYAS 111
Cdd:cd01819 1 LSFSGGGFRGMYHAGVLSAL-AERGLLDCvtyLAGTSGGAWVAATLYP 47
|
|
| BamA |
COG4775 |
Outer membrane protein assembly factor BamA [Cell wall/membrane/envelope biogenesis]; |
374-443 |
8.43e-04 |
|
Outer membrane protein assembly factor BamA [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 443807 [Multi-domain] Cd Length: 711 Bit Score: 42.77 E-value: 8.43e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981772145 374 ITDIEIRTSGGVPQRVVKDALHVKPGDTYDPKAVSRDLLTLTTGGNFESVtqQVVSNGdeNRLVIDAREK 443
Cdd:COG4775 1 IKDIRVEGLQRVEAGTVLSYLPLRVGDTFDDEKLDEAIKALYATGLFSDV--RIEREG--VVLVVKVKER 66
|
|
| Pat_TGL4-5_like |
cd07230 |
Triacylglycerol lipase 4 and 5; TGL4 and TGL5 are triacylglycerol lipases that are involved in ... |
61-105 |
4.37e-03 |
|
Triacylglycerol lipase 4 and 5; TGL4 and TGL5 are triacylglycerol lipases that are involved in triacylglycerol mobilization and degradation; they are found in lipid particles. Tgl4 is a functional ortholog of mammalian adipose TG lipase (ATGL) and is phosphorylated and activated by cyclin-dependent kinase 1 (Cdk1/Cdc28). TGL4 is 30% homologus to TGL3, whereas TGL5 is 26% homologus to TGL3. This family includes TGL4 (STC1) and TGL5 (STC2) from Saccharomyces cerevisiae.
Pssm-ID: 132868 Cd Length: 421 Bit Score: 40.28 E-value: 4.37e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 981772145 61 GRPAvgLVLSGGGARGYAHLGVLKVL-EDNRIP-IdcIAATSMGAVV 105
Cdd:cd07230 72 GRTA--LLLSGGGTFGMFHIGVLKALfEANLLPrI--ISGSSAGSIV 114
|
|
| |
